Detailed information for compound 729341

Basic information

Technical information
  • TDR Targets ID: 729341
  • Name: N-[2-[(2-thiophen-2-ylacetyl)amino]phenyl]but anamide
  • MW: 302.391 | Formula: C16H18N2O2S
  • H donors: 2 H acceptors: 2 LogP: 2.41 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)Nc1ccccc1NC(=O)Cc1cccs1
  • InChi: 1S/C16H18N2O2S/c1-2-6-15(19)17-13-8-3-4-9-14(13)18-16(20)11-12-7-5-10-21-12/h3-5,7-10H,2,6,11H2,1H3,(H,17,19)(H,18,20)
  • InChiKey: VKYCMSZZBQOGTE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[[2-(2-thienyl)acetyl]amino]phenyl]butanamide
  • N-[2-[[1-oxo-2-(2-thienyl)ethyl]amino]phenyl]butanamide
  • N-[2-[[2-(2-thienyl)acetyl]amino]phenyl]butyramide
  • N-[2-(2-thiophen-2-ylethanoylamino)phenyl]butanamide
  • ZINC06747126

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0025 0.0004
Echinococcus granulosus kelch ECH associated protein 1 like 0.0098 0.1221 0.1203
Brugia malayi intermediate filament protein 0.0028 0.0226 0.0646
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0377 0.0353
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0359 0.1082
Trichomonas vaginalis esterase, putative 0.0037 0.0359 0.1082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0503 0.0483
Echinococcus granulosus pyruvate kinase 0.0018 0.0081 0.0061
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0359 0.1049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0106 0.0866
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0359 0.1049
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0539 0.1595
Schistosoma mansoni kinase 0.005 0.0536 0.0513
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0855 0.2552
Echinococcus granulosus chromobox protein 1 0.0072 0.0855 0.0837
Brugia malayi Bromodomain containing protein 0.004 0.0393 0.1152
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0106 0.0892
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0036
Brugia malayi beta-lactamase family protein 0.0037 0.0359 0.1049
Loa Loa (eye worm) hypothetical protein 0.0042 0.0429 0.126
Schistosoma mansoni hypothetical protein 0.0021 0.0133 0.0108
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.3219 0.3835
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.032 0.2623
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0106 0.0281
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0359 0.0339
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0716 0.2129
Echinococcus multilocularis pyruvate kinase 0.0018 0.0081 0.0061
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0589 0.8225 1
Plasmodium vivax SET domain protein, putative 0.0031 0.0269 0.6742
Brugia malayi PHD-finger family protein 0.003 0.0258 0.0744
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0518 0.156
Echinococcus granulosus pyruvate kinase 0.0018 0.0081 0.0061
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0359 0.0049
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0359 0.0312
Echinococcus granulosus pyruvate kinase 0.0034 0.032 0.03
Loa Loa (eye worm) hypothetical protein 0.0037 0.0359 0.1049
Loa Loa (eye worm) hypothetical protein 0.0037 0.0359 0.1049
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.1221 0.3659
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0061 0.0041
Giardia lamblia Pyruvate kinase 0.0034 0.032 0.2099
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0359 0.1082
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0709 0.069
Loa Loa (eye worm) hypothetical protein 0.0049 0.0532 0.1571
Plasmodium falciparum phd finger protein, putative 0.003 0.0258 0.7411
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0106 0.0866
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0359 0.0312
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.032 0.0965
Mycobacterium tuberculosis Conserved protein 0.0037 0.0359 0.0312
Leishmania major hypothetical protein, conserved 0.0037 0.0359 0.2616
Schistosoma mansoni ap endonuclease 0.0019 0.0106 0.0081
Brugia malayi mbt repeat family protein 0.0049 0.0532 0.1572
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0269 0.0244
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0503 0.0483
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0106 0.0086
Loa Loa (eye worm) hypothetical protein 0.0024 0.0171 0.048
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0022
Echinococcus multilocularis pyruvate kinase 0.0034 0.032 0.03
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.032 0.2623
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0359 0.0339
Loa Loa (eye worm) beta-lactamase 0.0037 0.0359 0.1049
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0161 0.0141
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0359 0.0312
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.1535
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0106 0.0866
Echinococcus multilocularis peregrin 0.0033 0.0293 0.0273
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0023 0.0156 0.1281
Brugia malayi Bromodomain containing protein 0.0078 0.0934 0.279
Plasmodium falciparum pyruvate kinase 0.0034 0.032 1
Loa Loa (eye worm) MBCTL1 0.0056 0.0629 0.1866
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0404 0.0576
Brugia malayi beta-lactamase family protein 0.0037 0.0359 0.1049
Leishmania major hypothetical protein, conserved 0.0023 0.0156 0.0877
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0629 0.061
Echinococcus granulosus kelch ECH associated protein 1 0.0098 0.1221 0.1203
Schistosoma mansoni tsg101-related 0.006 0.0682 0.0659
Leishmania major pyruvate kinase 0.0034 0.032 0.2281
Brugia malayi PHD-finger family protein 0.0026 0.0196 0.0554
Echinococcus multilocularis pyruvate kinase 0.0027 0.0217 0.0197
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.052 0.0496
Brugia malayi beta-lactamase 0.0037 0.0359 0.1049
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0025 0.0004
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0106 0.0319
Schistosoma mansoni hypothetical protein 0.0098 0.1225 0.1203
Schistosoma mansoni survival motor neuron protein 0.005 0.0539 0.0516
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0802 0.6565
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0161 0.0136
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.052 0.0501
Loa Loa (eye worm) pyruvate kinase 0.0034 0.032 0.093
Schistosoma mansoni tsg101-related 0.006 0.0682 0.0659
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0503 0.1483
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.1236 0.1218
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0258 0.0234
Echinococcus granulosus kelch ECH associated protein 1 like 0.0098 0.1221 0.1203
Trypanosoma cruzi ISWI complex protein 0.0016 0.0054 0.0443
Brugia malayi hypothetical protein 0.0244 0.3314 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0871 0.2599
Plasmodium vivax hypothetical protein, conserved 0.003 0.0258 0.6372
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0503 0.1484
Schistosoma mansoni zinc finger protein 0.0016 0.0054 0.0029
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0802 0.6406
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0802 0.2389
Mycobacterium tuberculosis Conserved protein 0.0037 0.0359 0.0312
Onchocerca volvulus 0.0037 0.0359 0.0431
Brugia malayi chromobox protein homolog 3 0.004 0.0404 0.1186
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0629 0.061
Loa Loa (eye worm) hypothetical protein 0.004 0.0404 0.1185
Trypanosoma brucei pyruvate kinase 1 0.0034 0.032 0.2623
Loa Loa (eye worm) hypothetical protein 0.003 0.0258 0.0743
Brugia malayi hypothetical protein 0.0037 0.0359 0.1048
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0359 0.034
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0041 0.0087
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0089 0.023
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0802 0.0783
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0258 0.6372
Onchocerca volvulus Alhambra homolog 0.003 0.0258 0.0104
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0377 0.0357
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0947 0.0924
Brugia malayi Heterochromatin protein 1 0.0072 0.0855 0.2553
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0106 0.0443
Brugia malayi Pre-SET motif family protein 0.0031 0.0269 0.0775
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.1221 0.1199
Loa Loa (eye worm) hypothetical protein 0.004 0.0394 0.1154
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.1221 0.3659
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0392 0.0372
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0427 0.0407
Echinococcus multilocularis chromobox protein 1 0.0072 0.0855 0.0837
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1221 0.3677
Echinococcus granulosus lamin dm0 0.0028 0.0226 0.0206
Echinococcus multilocularis lamin dm0 0.0028 0.0226 0.0206
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0802 0.0779
Schistosoma mansoni hypothetical protein 0.003 0.0258 0.0234
Plasmodium vivax pyruvate kinase, putative 0.0034 0.032 0.8599
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1221 0.3677
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.2655 0.264
Onchocerca volvulus 0.0037 0.0359 0.0431
Schistosoma mansoni hypothetical protein 0.0037 0.0359 0.0335
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.032 0.0304
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0709 0.069
Echinococcus multilocularis zinc finger protein 0.002 0.0117 0.0097
Echinococcus multilocularis Kelch repeat type 1 0.0098 0.1225 0.1207
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0036
Schistosoma mansoni zinc finger protein 0.002 0.0117 0.0093
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0061 0.0146
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0106 0.1038
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0377 0.0353
Mycobacterium ulcerans hypothetical protein 0.0037 0.0359 0.0312
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0269 0.6742
Loa Loa (eye worm) hypothetical protein 0.0016 0.0061 0.0145
Schistosoma mansoni hypothetical protein 0.0016 0.0054 0.0029
Entamoeba histolytica hypothetical protein 0.0037 0.0359 0.2939
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0359 0.1082
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0427 0.0407
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.1221 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0854 0.2546
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0532 0.0988
Loa Loa (eye worm) hypothetical protein 0.0028 0.0226 0.0645
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.1236 0.1218
Schistosoma mansoni tsg101-related 0.0049 0.0526 0.0502
Entamoeba histolytica hypothetical protein 0.0037 0.0359 0.2939
Schistosoma mansoni hypothetical protein 0.0175 0.2326 0.2307
Schistosoma mansoni hypothetical protein 0.005 0.0539 0.0516
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0171 0.1404
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.032 0.0965
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0855 0.2577
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0061 0.0145
Echinococcus multilocularis musashi 0.0028 0.0226 0.0206
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0377 0.1102
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0072 0.0854 0.0835
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0532 0.0512
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.008 0.0055
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0061 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1221 0.3677
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0589 0.8225 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.032 0.093
Trypanosoma cruzi ISWI complex protein 0.0016 0.0054 0.0443
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0023 0.0156 0.1281
Schistosoma mansoni hypothetical protein 0.0304 0.4159 0.4144
Schistosoma mansoni pyruvate kinase 0.0034 0.032 0.0296
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0503 0.0483
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.3314 0.33
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.008 0.006
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0448 0.1349
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0061 0.0041
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0072 0.0854 0.0835
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.008 0.0055
Entamoeba histolytica hypothetical protein 0.0037 0.0359 0.2939
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0563 0.1667
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0331 0.0963
Echinococcus multilocularis chromobox protein 1 0.0072 0.0855 0.0837
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1221 0.3677
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.3314 0.33
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0106 0.5
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1221 1
Schistosoma mansoni pyruvate kinase 0.0018 0.0081 0.0056
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0392 0.0372
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0629 0.061
Loa Loa (eye worm) hypothetical protein 0.0056 0.0629 0.1866
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0532 0.0512
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0503 0.0483
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0061 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0236 0.0711
Echinococcus multilocularis pyruvate kinase 0.0018 0.0081 0.0061
Giardia lamblia Kinase, PLK 0.0098 0.1221 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0358 0.0338
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0589 0.8225 1
Schistosoma mansoni lamin 0.0028 0.0226 0.0202
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0258 0.6372
Echinococcus granulosus chromobox protein 1 0.0072 0.0855 0.0837
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0258 0.0238
Echinococcus multilocularis kelch ECH associated protein 1 0.0098 0.1221 0.1203
Schistosoma mansoni intermediate filament proteins 0.0028 0.0226 0.0202
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.1221 0.3215
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.032 0.0931
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0133 0.0362
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0036
Loa Loa (eye worm) hypothetical protein 0.0035 0.0331 0.0963
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0359 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0106 0.0282
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.032 0.0931
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0629 0.1866
Schistosoma mansoni lamin 0.0028 0.0226 0.0202
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0563 0.1668
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0106 0.5
Onchocerca volvulus 0.0037 0.0359 0.0431
Echinococcus granulosus intermediate filament protein 0.0028 0.0226 0.0206
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0855 0.2577
Echinococcus granulosus GPCR family 2 0.0016 0.0061 0.0041
Brugia malayi CHD4 protein 0.0014 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0044 0.0457 0.1345
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0518 0.156
Brugia malayi mbt repeat family protein 0.0049 0.0532 0.1572
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.2896 0.8734
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0106 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0437 0.0413
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0532 0.0512
Onchocerca volvulus 0.0032 0.028 0.0174
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1221 1
Onchocerca volvulus 0.0049 0.0532 0.0988
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0532 0.0512
Schistosoma mansoni hypothetical protein 0.0175 0.2326 0.2307
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0252 0.0232
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0359 0.0312
Schistosoma mansoni chromobox protein 0.0072 0.0855 0.0833
Schistosoma mansoni chromobox protein 0.0072 0.0855 0.0833
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0171 0.048
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0359 0.1082
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0226 0.0646
Loa Loa (eye worm) hypothetical protein 0.0037 0.0359 0.1049
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.032 0.0264
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0036
Brugia malayi Pre-SET motif family protein 0.0215 0.2896 0.8734
Schistosoma mansoni pyruvate kinase 0.0034 0.032 0.0296
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0061 0.0041
Trichomonas vaginalis set domain proteins, putative 0.0245 0.332 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0106 0.0892
Loa Loa (eye worm) hypothetical protein 0.0052 0.0563 0.1667
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.032 0.2623
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0802 0.6565
Mycobacterium ulcerans lipase LipD 0.0037 0.0359 0.0312
Mycobacterium ulcerans beta-lactamase 0.0037 0.0359 0.0312
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0013 0.0002
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.1221 0.1203
Echinococcus multilocularis microtubule associated protein 2 0.0713 1 1
Echinococcus granulosus lamin 0.0028 0.0226 0.0206
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.0808
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0802 0.6565
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0236 0.0711
Echinococcus multilocularis pyruvate kinase 0.0018 0.0081 0.0061
Echinococcus granulosus geminin 0.0175 0.2326 0.2311
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0532 0.0508
Trypanosoma brucei polo-like protein kinase 0.0098 0.1221 1
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0448 0.1349
Echinococcus multilocularis kelch ECH associated protein 1 0.0098 0.1221 0.1203
Loa Loa (eye worm) hypothetical protein 0.0027 0.0219 0.0623
Entamoeba histolytica hypothetical protein 0.0037 0.0359 0.2939
Leishmania major pyruvate kinase 0.0034 0.032 0.2281
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0359 0.0312
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0226 0.0645
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0106 0.0319
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0358 0.0338
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.052 0.0501
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0359 0.2943
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0359 0.1082
Schistosoma mansoni bromodomain containing protein 0.0065 0.0761 0.0738
Loa Loa (eye worm) hypothetical protein 0.0052 0.0565 0.1673
Loa Loa (eye worm) hypothetical protein 0.0244 0.3314 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.2655 0.264
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0629 0.061
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0359 0.0312
Onchocerca volvulus 0.005 0.0539 0.1013
Mycobacterium leprae Probable lipase LipE 0.0037 0.0359 0.0049
Echinococcus multilocularis geminin 0.0175 0.2326 0.2311
Brugia malayi hypothetical protein 0.0072 0.0854 0.2547
Toxoplasma gondii ABC1 family protein 0.0037 0.0359 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0025 0.0035
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.032 0.0304
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0359 0.034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0359 0.0335
Echinococcus granulosus pyruvate kinase 0.0018 0.0081 0.0061
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0359 0.0335
Chlamydia trachomatis pyruvate kinase 0.0034 0.032 0.5
Mycobacterium ulcerans pyruvate kinase 0.0034 0.032 0.0264
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0563 0.1668
Echinococcus granulosus zinc finger protein 0.002 0.0117 0.0097
Brugia malayi jmjC domain containing protein 0.0038 0.0377 0.1103
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.032 0.8599
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0802 0.0783
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1221 0.3677
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0802 0.6565
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0404 0.1217
Echinococcus granulosus pyruvate kinase 0.0034 0.032 0.03
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0532 0.0508
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0359 0.0312
Trypanosoma brucei ISWI complex protein 0.0016 0.0054 0.0443
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0359 0.0312
Loa Loa (eye worm) hypothetical protein 0.0037 0.0359 0.1049
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.032 0.0304
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1221 0.3677
Onchocerca volvulus 0.0043 0.0437 0.0681
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0161 0.0141
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0106 0.0866
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0258 0.0743
Giardia lamblia PHD finger protein 15 0.003 0.0258 0.1556
Onchocerca volvulus 0.0245 0.332 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.1221 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.008 0.006
Trichomonas vaginalis hypothetical protein 0.0035 0.0328 0.0987
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0629 0.0606
Loa Loa (eye worm) hypothetical protein 0.0037 0.0359 0.1049
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0226 0.0645
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0049 0.0526 0.4306
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0258 0.0238
Echinococcus multilocularis pyruvate kinase 0.0034 0.032 0.03
Mycobacterium tuberculosis Conserved protein 0.0037 0.0359 0.0312
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0106 0.0218
Echinococcus multilocularis GPCR, family 2 0.0016 0.0061 0.0041
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0349 0.0329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0503 0.0479
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0359 0.2943
Schistosoma mansoni ap endonuclease 0.0019 0.0106 0.0081
Loa Loa (eye worm) pyruvate kinase 0.0034 0.032 0.093
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0404 0.1217
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0448 0.0717
Brugia malayi Bromodomain containing protein 0.0033 0.0293 0.0849
Loa Loa (eye worm) pyruvate kinase 0.0034 0.032 0.093
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0532 0.0508
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0503 0.0479
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0269 0.0249
Brugia malayi jmjC domain containing protein 0.0099 0.1236 0.3705
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0532 0.1571
Echinococcus multilocularis lamin 0.0028 0.0226 0.0206
Echinococcus granulosus peregrin 0.0033 0.0293 0.0273
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0359 0.0335
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0041 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1221 0.3677
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0802 0.2389
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0359 0.2943
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0359 0.0312
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.052 0.0496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0503 0.0479
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.1221 0.1203
Loa Loa (eye worm) hypothetical protein 0.0037 0.0359 0.1049
Schistosoma mansoni hypothetical protein 0.0035 0.0331 0.0307
Schistosoma mansoni microtubule-associated protein tau 0.0713 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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