Detailed information for compound 729341

Basic information

Technical information
  • TDR Targets ID: 729341
  • Name: N-[2-[(2-thiophen-2-ylacetyl)amino]phenyl]but anamide
  • MW: 302.391 | Formula: C16H18N2O2S
  • H donors: 2 H acceptors: 2 LogP: 2.41 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)Nc1ccccc1NC(=O)Cc1cccs1
  • InChi: 1S/C16H18N2O2S/c1-2-6-15(19)17-13-8-3-4-9-14(13)18-16(20)11-12-7-5-10-21-12/h3-5,7-10H,2,6,11H2,1H3,(H,17,19)(H,18,20)
  • InChiKey: VKYCMSZZBQOGTE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-[[2-(2-thienyl)acetyl]amino]phenyl]butanamide
  • N-[2-[[1-oxo-2-(2-thienyl)ethyl]amino]phenyl]butanamide
  • N-[2-[[2-(2-thienyl)acetyl]amino]phenyl]butyramide
  • N-[2-(2-thiophen-2-ylethanoylamino)phenyl]butanamide
  • ZINC06747126

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0359 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0106 0.0866
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0061 0.0041
Onchocerca volvulus 0.0245 0.332 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0565 0.1673
Schistosoma mansoni pyruvate kinase 0.0018 0.0081 0.0056
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0377 0.0353
Brugia malayi jmjC domain containing protein 0.0038 0.0377 0.1103
Mycobacterium ulcerans beta-lactamase 0.0037 0.0359 0.0312
Echinococcus multilocularis lamin dm0 0.0028 0.0226 0.0206
Loa Loa (eye worm) hypothetical protein 0.004 0.0394 0.1154
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0359 0.0312
Schistosoma mansoni zinc finger protein 0.002 0.0117 0.0093
Echinococcus granulosus intermediate filament protein 0.0028 0.0226 0.0206
Chlamydia trachomatis pyruvate kinase 0.0034 0.032 0.5
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.032 0.2623
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0802 0.2389
Onchocerca volvulus 0.005 0.0539 0.1013
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0025 0.0004
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0025 0.0035
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1221 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0854 0.2546
Trypanosoma brucei pyruvate kinase 1 0.0034 0.032 0.2623
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.1221 0.1199
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.3314 0.33
Giardia lamblia PHD finger protein 15 0.003 0.0258 0.1556
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0258 0.0238
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0503 0.0483
Schistosoma mansoni bromodomain containing protein 0.0065 0.0761 0.0738
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0226 0.0646
Loa Loa (eye worm) hypothetical protein 0.0073 0.0871 0.2599
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0359 0.1082
Schistosoma mansoni chromobox protein 0.0072 0.0855 0.0833
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0437 0.0413
Trichomonas vaginalis hypothetical protein 0.0035 0.0328 0.0987
Schistosoma mansoni survival motor neuron protein 0.005 0.0539 0.0516
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0106 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.052 0.0501
Brugia malayi mbt repeat family protein 0.0049 0.0532 0.1572
Entamoeba histolytica hypothetical protein 0.0037 0.0359 0.2939
Echinococcus multilocularis lamin 0.0028 0.0226 0.0206
Trypanosoma brucei ISWI complex protein 0.0016 0.0054 0.0443
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0629 0.0606
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0532 0.0508
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.032 0.0304
Echinococcus multilocularis chromobox protein 1 0.0072 0.0855 0.0837
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1221 0.3677
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0404 0.1217
Entamoeba histolytica hypothetical protein 0.0037 0.0359 0.2939
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0359 0.2943
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0133 0.0362
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0709 0.069
Schistosoma mansoni zinc finger protein 0.0016 0.0054 0.0029
Loa Loa (eye worm) pyruvate kinase 0.0034 0.032 0.093
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.2655 0.264
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0013 0.0002
Brugia malayi CHD4 protein 0.0014 0.0025 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0022
Entamoeba histolytica hypothetical protein 0.0037 0.0359 0.2939
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0629 0.1866
Echinococcus multilocularis microtubule associated protein 2 0.0713 1 1
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0072 0.0854 0.0835
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.032 0.0264
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0448 0.1349
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0359 0.0312
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.3219 0.3835
Echinococcus multilocularis pyruvate kinase 0.0027 0.0217 0.0197
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.052 0.0496
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.1236 0.1218
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0049 0.0526 0.4306
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0161 0.0141
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0023 0.0156 0.1281
Trypanosoma brucei polo-like protein kinase 0.0098 0.1221 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0106 0.0319
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0802 0.6565
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.032 0.2623
Trypanosoma cruzi ISWI complex protein 0.0016 0.0054 0.0443
Brugia malayi jmjC domain containing protein 0.0099 0.1236 0.3705
Echinococcus granulosus pyruvate kinase 0.0018 0.0081 0.0061
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0359 0.0335
Echinococcus granulosus zinc finger protein 0.002 0.0117 0.0097
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.008 0.0055
Loa Loa (eye worm) pyruvate kinase 0.0034 0.032 0.093
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0269 0.6742
Schistosoma mansoni hypothetical protein 0.003 0.0258 0.0234
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0377 0.1102
Brugia malayi beta-lactamase 0.0037 0.0359 0.1049
Brugia malayi chromobox protein homolog 3 0.004 0.0404 0.1186
Onchocerca volvulus 0.0049 0.0532 0.0988
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0106 0.0218
Echinococcus multilocularis pyruvate kinase 0.0034 0.032 0.03
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0036
Schistosoma mansoni hypothetical protein 0.0037 0.0359 0.0335
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0855 0.2577
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.032 0.0965
Loa Loa (eye worm) hypothetical protein 0.0044 0.0457 0.1345
Onchocerca volvulus 0.0043 0.0437 0.0681
Echinococcus granulosus pyruvate kinase 0.0034 0.032 0.03
Schistosoma mansoni hypothetical protein 0.005 0.0539 0.0516
Echinococcus granulosus lamin 0.0028 0.0226 0.0206
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.008 0.006
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0629 0.061
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0802 0.0779
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0106 0.0086
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0161 0.0141
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0036
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.008 0.006
Echinococcus multilocularis pyruvate kinase 0.0018 0.0081 0.0061
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0532 0.1571
Schistosoma mansoni pyruvate kinase 0.0034 0.032 0.0296
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.1221 0.1203
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0518 0.156
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0061 0.0041
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0041 0.0086
Echinococcus granulosus pyruvate kinase 0.0034 0.032 0.03
Schistosoma mansoni hypothetical protein 0.0098 0.1225 0.1203
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.052 0.0496
Echinococcus multilocularis zinc finger protein 0.002 0.0117 0.0097
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0106 0.0282
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.032 0.0931
Echinococcus multilocularis Kelch repeat type 1 0.0098 0.1225 0.1207
Mycobacterium ulcerans hypothetical protein 0.0037 0.0359 0.0312
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0359 0.1049
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0258 0.6372
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0106 0.0892
Trichomonas vaginalis esterase, putative 0.0037 0.0359 0.1082
Onchocerca volvulus Alhambra homolog 0.003 0.0258 0.0104
Plasmodium falciparum phd finger protein, putative 0.003 0.0258 0.7411
Loa Loa (eye worm) hypothetical protein 0.0032 0.028 0.0808
Trypanosoma cruzi ISWI complex protein 0.0016 0.0054 0.0443
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1221 0.3677
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0359 0.0312
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0061 0.0145
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0359 0.0312
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0106 0.0866
Leishmania major pyruvate kinase 0.0034 0.032 0.2281
Loa Loa (eye worm) hypothetical protein 0.0049 0.0532 0.1571
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0061 0.0146
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0359 0.1049
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.1221 1
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.032 0.0965
Loa Loa (eye worm) hypothetical protein 0.0016 0.0061 0.0145
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0629 0.061
Schistosoma mansoni chromobox protein 0.0072 0.0855 0.0833
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0349 0.0329
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0392 0.0372
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0061 0.0041
Schistosoma mansoni hypothetical protein 0.0021 0.0133 0.0108
Schistosoma mansoni intermediate filament proteins 0.0028 0.0226 0.0202
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0359 0.1082
Echinococcus multilocularis musashi 0.0028 0.0226 0.0206
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.2655 0.264
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1221 0.3677
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.032 0.8599
Loa Loa (eye worm) hypothetical protein 0.0024 0.0171 0.048
Onchocerca volvulus 0.0037 0.0359 0.0431
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0802 0.6565
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0041 0.0087
Echinococcus granulosus chromobox protein 1 0.0072 0.0855 0.0837
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0532 0.0508
Echinococcus multilocularis GPCR, family 2 0.0016 0.0061 0.0041
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0161 0.0136
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0331 0.0963
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.1221 1
Brugia malayi hypothetical protein 0.0244 0.3314 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0359 0.1049
Brugia malayi hypothetical protein 0.0037 0.0359 0.1048
Schistosoma mansoni hypothetical protein 0.0175 0.2326 0.2307
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0589 0.8225 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0358 0.0338
Loa Loa (eye worm) hypothetical protein 0.004 0.0404 0.1185
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0503 0.0483
Brugia malayi PHD-finger family protein 0.003 0.0258 0.0744
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0855 0.2577
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0226 0.0645
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.1221 0.1203
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0106 0.0319
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0106 0.5
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0025 0.0004
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.1221 0.3659
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0503 0.1484
Brugia malayi Pre-SET motif family protein 0.0031 0.0269 0.0775
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0252 0.0232
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0563 0.1667
Echinococcus multilocularis chromobox protein 1 0.0072 0.0855 0.0837
Echinococcus granulosus kelch ECH associated protein 1 0.0098 0.1221 0.1203
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0629 0.061
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0269 0.0249
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0589 0.8225 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0359 0.034
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0106 0.0086
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0629 0.061
Leishmania major pyruvate kinase 0.0034 0.032 0.2281
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0171 0.048
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0563 0.1668
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.032 0.0931
Echinococcus granulosus kelch ECH associated protein 1 like 0.0098 0.1221 0.1203
Echinococcus multilocularis kelch ECH associated protein 1 0.0098 0.1221 0.1203
Loa Loa (eye worm) hypothetical protein 0.0042 0.0429 0.126
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.032 0.0304
Echinococcus multilocularis peregrin 0.0033 0.0293 0.0273
Mycobacterium tuberculosis Conserved protein 0.0037 0.0359 0.0312
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0377 0.0357
Loa Loa (eye worm) MBCTL1 0.0056 0.0629 0.1866
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0532 0.0512
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0089 0.023
Brugia malayi Bromodomain containing protein 0.004 0.0393 0.1152
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0802 0.6406
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0359 0.0312
Brugia malayi hypothetical protein 0.0072 0.0854 0.2547
Toxoplasma gondii exonuclease III APE 0.0019 0.0106 0.0892
Toxoplasma gondii ABC1 family protein 0.0037 0.0359 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0359 0.1049
Schistosoma mansoni lamin 0.0028 0.0226 0.0202
Onchocerca volvulus 0.0032 0.028 0.0174
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0358 0.0338
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.2896 0.8734
Schistosoma mansoni kinase 0.005 0.0536 0.0513
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0448 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0404 0.1217
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.032 0.0304
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0258 0.6372
Loa Loa (eye worm) hypothetical protein 0.0056 0.0629 0.1866
Brugia malayi beta-lactamase family protein 0.0037 0.0359 0.1049
Mycobacterium tuberculosis Conserved protein 0.0037 0.0359 0.0312
Trichomonas vaginalis set domain proteins, putative 0.0245 0.332 1
Echinococcus multilocularis geminin 0.0175 0.2326 0.2311
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0258 0.0238
Brugia malayi Heterochromatin protein 1 0.0072 0.0855 0.2553
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0404 0.0576
Echinococcus multilocularis kelch ECH associated protein 1 0.0098 0.1221 0.1203
Schistosoma mansoni lamin 0.0028 0.0226 0.0202
Loa Loa (eye worm) hypothetical protein 0.0037 0.0359 0.1049
Echinococcus granulosus pyruvate kinase 0.0018 0.0081 0.0061
Entamoeba histolytica hypothetical protein 0.0037 0.0359 0.2939
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0377 0.0353
Schistosoma mansoni tsg101-related 0.006 0.0682 0.0659
Giardia lamblia Pyruvate kinase 0.0034 0.032 0.2099
Echinococcus multilocularis pyruvate kinase 0.0018 0.0081 0.0061
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0359 0.0312
Loa Loa (eye worm) hypothetical protein 0.0244 0.3314 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0802 0.6565
Echinococcus granulosus chromobox protein 1 0.0072 0.0855 0.0837
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0359 0.0335
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1221 0.3677
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0258 0.0234
Echinococcus granulosus GPCR family 2 0.0016 0.0061 0.0041
Loa Loa (eye worm) hypothetical protein 0.0037 0.0359 0.1049
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.052 0.0501
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1221 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0269 0.0244
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0061 0.0146
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0359 0.0339
Brugia malayi Bromodomain containing protein 0.0078 0.0934 0.279
Schistosoma mansoni hypothetical protein 0.0035 0.0331 0.0307
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0061 0.0041
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0023 0.0156 0.1281
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0359 0.1082
Schistosoma mansoni tsg101-related 0.0049 0.0526 0.0502
Brugia malayi Bromodomain containing protein 0.0033 0.0293 0.0849
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0072 0.0854 0.0835
Brugia malayi PHD-finger family protein 0.0026 0.0196 0.0554
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0802 0.0783
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0448 0.1349
Loa Loa (eye worm) hypothetical protein 0.0037 0.0359 0.1049
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1221 0.3677
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0359 0.0339
Plasmodium vivax SET domain protein, putative 0.0031 0.0269 0.6742
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0106 0.1038
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0258 0.0743
Loa Loa (eye worm) hypothetical protein 0.0034 0.032 0.093
Brugia malayi beta-lactamase family protein 0.0037 0.0359 0.1049
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1221 0.3677
Brugia malayi mbt repeat family protein 0.0049 0.0532 0.1572
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0427 0.0407
Plasmodium falciparum pyruvate kinase 0.0034 0.032 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0219 0.0623
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0359 0.2943
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0532 0.0508
Schistosoma mansoni ap endonuclease 0.0019 0.0106 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0503 0.0479
Brugia malayi intermediate filament protein 0.0028 0.0226 0.0646
Schistosoma mansoni hypothetical protein 0.0175 0.2326 0.2307
Plasmodium vivax pyruvate kinase, putative 0.0034 0.032 0.8599
Schistosoma mansoni ap endonuclease 0.0019 0.0106 0.0081
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0359 0.2943
Schistosoma mansoni microtubule-associated protein tau 0.0713 1 1
Echinococcus granulosus peregrin 0.0033 0.0293 0.0273
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0532 0.0512
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.032 0.2623
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0106 0.0281
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0171 0.1404
Echinococcus granulosus geminin 0.0175 0.2326 0.2311
Loa Loa (eye worm) hypothetical protein 0.0037 0.0359 0.1049
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0532 0.0988
Loa Loa (eye worm) hypothetical protein 0.0048 0.052 0.1535
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0503 0.0479
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.1221 0.3659
Echinococcus multilocularis pyruvate kinase 0.0018 0.0081 0.0061
Loa Loa (eye worm) hypothetical protein 0.0028 0.0226 0.0645
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0359 0.0335
Echinococcus multilocularis pyruvate kinase 0.0034 0.032 0.03
Echinococcus granulosus lamin dm0 0.0028 0.0226 0.0206
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0532 0.0512
Loa Loa (eye worm) hypothetical protein 0.0052 0.0563 0.1667
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0539 0.1595
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0106 0.0866
Loa Loa (eye worm) hypothetical protein 0.003 0.0258 0.0743
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0392 0.0372
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0359 0.0312
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0802 0.2389
Mycobacterium tuberculosis Conserved protein 0.0037 0.0359 0.0312
Onchocerca volvulus 0.0037 0.0359 0.0431
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.3314 0.33
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1221 0.3677
Loa Loa (eye worm) beta-lactamase 0.0037 0.0359 0.1049
Loa Loa (eye worm) pyruvate kinase 0.0034 0.032 0.093
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.1236 0.1218
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0359 0.0312
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0427 0.0407
Schistosoma mansoni hypothetical protein 0.0304 0.4159 0.4144
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0802 0.6565
Schistosoma mansoni pyruvate kinase 0.0034 0.032 0.0296
Mycobacterium ulcerans lipase LipD 0.0037 0.0359 0.0312
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0947 0.0924
Brugia malayi Pre-SET motif family protein 0.0215 0.2896 0.8734
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0106 0.0866
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0106 0.0443
Leishmania major hypothetical protein, conserved 0.0037 0.0359 0.2616
Onchocerca volvulus 0.0037 0.0359 0.0431
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0359 0.0312
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0226 0.0645
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0359 0.0049
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0359 0.034
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0359 0.1082
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0802 0.0783
Mycobacterium leprae Probable lipase LipE 0.0037 0.0359 0.0049
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0589 0.8225 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0359 0.1082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0503 0.0479
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.008 0.0055
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0563 0.1668
Echinococcus granulosus pyruvate kinase 0.0018 0.0081 0.0061
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0716 0.2129
Schistosoma mansoni hypothetical protein 0.0016 0.0061 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0236 0.0711
Giardia lamblia Kinase, PLK 0.0098 0.1221 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0503 0.0483
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.1221 0.3215
Mycobacterium ulcerans pyruvate kinase 0.0034 0.032 0.0264
Loa Loa (eye worm) hypothetical protein 0.0035 0.0331 0.0963
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0532 0.0512
Echinococcus granulosus kelch ECH associated protein 1 like 0.0098 0.1221 0.1203
Leishmania major hypothetical protein, conserved 0.0023 0.0156 0.0877
Schistosoma mansoni hypothetical protein 0.0016 0.0054 0.0029
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0518 0.156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0503 0.0483
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0503 0.1483
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0236 0.0711
Schistosoma mansoni tsg101-related 0.006 0.0682 0.0659
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0709 0.069
Plasmodium vivax hypothetical protein, conserved 0.003 0.0258 0.6372
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0855 0.2552

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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