Detailed information for compound 729388

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 298.36 | Formula: C16H14N2O2S
  • H donors: 2 H acceptors: 3 LogP: 3.23 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1cc(C)c(c(c1)c1nc2c(s1)cccc2)O
  • InChi: 1S/C16H14N2O2S/c1-9-7-11(17-10(2)19)8-12(15(9)20)16-18-13-5-3-4-6-14(13)21-16/h3-8,20H,1-2H3,(H,17,19)
  • InChiKey: AYDMPCKYVDLEDT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii thioredoxin reductase 0.0046 0.0421 0.4624
Loa Loa (eye worm) hypothetical protein 0.0176 0.1872 0.1872
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.5626 0.7153
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0114 0.0386
Toxoplasma gondii aminopeptidase N, putative 0.0024 0.0171 0.1881
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0022 0.0152 0.167
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0421 0.3235
Echinococcus granulosus geminin 0.0496 0.5461 0.5461
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.091 0.091
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0035 0.0299 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Schistosoma mansoni inositol monophosphatase 0.0036 0.031 0.031
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0083 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Plasmodium vivax SET domain protein, putative 0.009 0.091 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0114 0.2729
Brugia malayi Importin beta-1 subunit 0.0084 0.0849 0.1233
Echinococcus multilocularis snurportin 1 0.0901 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0035 0.0299 0.0299
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0149 0.1578 0.1578
Schistosoma mansoni ferritin 0.0026 0.0198 0.0198
Echinococcus granulosus serine:threonine protein kinase SMG1 0.002 0.0126 0.0126
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1216 0.2205
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0404 0.0404
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0421 0.0421
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0062 0.0599 0.6584
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0511 0.5626 0.5626
Trichomonas vaginalis ran, putative 0.0062 0.0599 0.0704
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0035 0.0299 0.2075
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0068 0.0666 0.5578
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0021 0.003
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0114 0.0605
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.031 0.2174
Brugia malayi hypothetical protein 0.0027 0.0201 0.0292
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0021 0.0021
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0027 0.0201 0.0201
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0114 0.0082
Mycobacterium ulcerans glutaminase 0.0269 0.2913 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0035 0.03 0.2079
Schistosoma mansoni ferritin 0.0026 0.0198 0.0198
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.3658 0.4628
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0126 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0126 0.0098
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0623 0.517
Schistosoma mansoni hypothetical protein 0.0016 0.0087 0.0087
Brugia malayi beta-lactamase family protein 0.0074 0.0736 0.1069
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0109 0.1128 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0866 0.0866
Trypanosoma brucei calpain, putative 0.0109 0.1128 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0277 0.0291
Echinococcus multilocularis thyroid hormone receptor alpha 0.0141 0.1487 0.1487
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0114 0.0297
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0083 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0083 0.0317
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0277 0.3045
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0076 0.0033
Schistosoma mansoni pyruvate kinase 0.0033 0.0277 0.0277
Echinococcus granulosus transcription factor Dp 1 0.0037 0.032 0.032
Schistosoma mansoni DNA polymerase eta 0.0019 0.0114 0.0114
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0062 0.0599 0.0599
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0114 0.0605
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0083 0.0007
Trypanosoma cruzi importin beta-1 subunit, putative 0.0068 0.067 0.5618
Echinococcus multilocularis dna polymerase eta 0.0019 0.0114 0.0114
Giardia lamblia DINP protein human, muc B family 0.0019 0.0114 0.0601
Schistosoma mansoni coup transcription factor 0.0011 0.0021 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0114 0.0605
Trypanosoma brucei unspecified product 0.0019 0.0114 0.0605
Schistosoma mansoni ap endonuclease 0.0019 0.0114 0.0114
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0018 0.0018
Schistosoma mansoni pyruvate kinase 0.0033 0.0277 0.0277
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0044 0.0398 0.0398
Giardia lamblia GTOR 0.0035 0.0299 0.4192
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0021 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0277 0.0353
Schistosoma mansoni importin-beta 2 0.0016 0.0082 0.0082
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0277 0.0779
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0484 0.0484
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0404 0.0404
Echinococcus multilocularis aminopeptidase N 0.0068 0.0666 0.0666
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.002 0.0126 0.031
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0736 0.0736
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0021 0.003
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0171 0.1077
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0623 0.5321
Schistosoma mansoni pyruvate kinase 0.0017 0.0095 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Echinococcus multilocularis tumor protein p63 0.0351 0.3839 0.3839
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0035 0.0051
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0021 0.0021
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0114 0.011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0607 0.0607
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0623 0.6882 0.6882
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0114 0.0605
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0421 0.4092
Brugia malayi N-terminal motif family protein 0.0176 0.1872 0.2719
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0035 0.0299 0.0299
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0083 0.0041
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0114 0.022
Schistosoma mansoni hypothetical protein 0.0901 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0114 0.0605
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0277 0.2119
Brugia malayi CXXC zinc finger family protein 0.0028 0.0218 0.0316
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0021 0.0021
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0666 0.0666
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0109 0.1128 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0152 0.013
Leishmania major GTP-binding protein, putative 0.0062 0.0599 0.4943
Loa Loa (eye worm) hypothetical protein 0.0033 0.0277 0.0277
Mycobacterium ulcerans hypothetical protein 0.0074 0.0736 0.2308
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0277 0.0353
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0035 0.0299 0.2071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0447 0.0509
Loa Loa (eye worm) hypothetical protein 0.0044 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0084 0.0849 0.0849
Schistosoma mansoni hypothetical protein 0.04 0.4381 0.4381
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0126 0.0098
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0016 0.0082 0.0313
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0083 0.012
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0109 0.1128 1
Onchocerca volvulus 0.0074 0.0736 0.0938
Toxoplasma gondii aminopeptidase n, putative 0.0024 0.0171 0.1881
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0109 0.1128 1
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.5626 0.7153
Echinococcus multilocularis geminin 0.0496 0.5461 0.5461
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0021 0.0021
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1084 0.1948
Plasmodium falciparum pyruvate kinase 0.0033 0.0277 0.2544
Mycobacterium leprae Probable lipase LipE 0.0074 0.0736 0.5284
Loa Loa (eye worm) tumor suppressor 0.0314 0.3424 0.3424
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.091 0.091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0095 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0021 0.003
Loa Loa (eye worm) hypothetical protein 0.0074 0.0736 0.0736
Leishmania major importin beta-1 subunit, putative 0.0068 0.067 0.562
Schistosoma mansoni inositol monophosphatase 0.0036 0.031 0.031
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.002 0.0126 0.0126
Loa Loa (eye worm) glutaminase 2 0.0269 0.2913 0.2913
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0536 0.5885
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.031 0.3404
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0623 0.0623
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0114 0.0306
Mycobacterium ulcerans aminopeptidase N PepN 0.0068 0.0666 0.206
Plasmodium vivax importin-beta 2, putative 0.0084 0.0849 0.9262
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0484 0.0703
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0736 0.1271
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0024 0.0171 0.0171
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0299 0.3287
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0736 0.6246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0623 0.0623
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0021 0.003
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0049 0.0447 0.3692
Schistosoma mansoni transcription factor LCR-F1 0.0144 0.1515 0.1515
Brugia malayi glutaminase DH11.1 0.0269 0.2913 0.4233
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1216 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0062 0.0599 0.0871
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0021 0.0021
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0062 0.0599 0.0599
Entamoeba histolytica aminopeptidase, putative 0.0068 0.0666 0.4074
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.031 0.031
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0736 0.0879
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0068 0.0666 0.5578
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0114 0.0114
Loa Loa (eye worm) glutathione reductase 0.0046 0.0421 0.0421
Echinococcus granulosus GPCR family 2 0.0016 0.0087 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.091 0.091
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0087 0.0087
Trypanosoma brucei hypothetical protein 0.0109 0.1128 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0068 0.0666 0.0666
Schistosoma mansoni hypothetical protein 0.0015 0.0076 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0021 0.0021
Toxoplasma gondii ABC1 family protein 0.0074 0.0736 0.8084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0021 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Toxoplasma gondii HEAT repeat-containing protein 0.0084 0.0849 0.9328
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0114 0.0081
Echinococcus multilocularis dnaJ subfamily B 0.04 0.4381 0.4381
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0109 0.1128 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.031 0.2174
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0109 0.1128 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0109 0.1128 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0404 0.0404
Leishmania major phosphatidylinositol 3-kinase, putative 0.0035 0.0299 0.2075
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.5626 0.7153
Schistosoma mansoni ferritin light chain 0.0026 0.0198 0.0198
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0666 0.0666
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0736 0.1271
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0109 0.1128 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0021 0.0021
Loa Loa (eye worm) inositol-1 0.0036 0.031 0.031
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0447 0.065
Trypanosoma brucei importin beta-1 subunit, putative 0.0084 0.0849 0.7413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0666 0.0666
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0299 0.0435
Trypanosoma brucei importin beta-1 subunit, putative 0.0084 0.0849 0.7413
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0109 0.1128 1
Trichomonas vaginalis glutaminase, putative 0.0269 0.2913 0.3673
Entamoeba histolytica hypothetical protein 0.0144 0.1515 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0736 0.0879
Schistosoma mansoni hypothetical protein 0.0144 0.1515 0.1515
Echinococcus granulosus pyruvate kinase 0.0017 0.0095 0.0095
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0736 0.0879
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0114 0.0605
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0171 0.0155
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0736 0.0879
Toxoplasma gondii exonuclease III APE 0.0019 0.0114 0.1252
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0277 0.0379
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0114 0.006
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0021 0.0021
Schistosoma mansoni cpg binding protein 0.0028 0.0218 0.0218
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0299 0.0435
Leishmania major DNA polymerase kappa, putative 0.0019 0.0114 0.0302
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0035 0.0299 0.0299
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0736 0.6365
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0021 0.0021
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0114 0.0114
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0171 0.0853
Brugia malayi Thioredoxin reductase 0.0046 0.0421 0.0611
Onchocerca volvulus 0.0709 0.7846 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0109 0.1128 1
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0198 0.0407
Loa Loa (eye worm) peptidase family M1 containing protein 0.0024 0.0171 0.0171
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0087 0.0087
Leishmania major pyruvate kinase 0.0033 0.0277 0.1865
Entamoeba histolytica Ran family GTPase 0.0062 0.0599 0.361
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0277 0.1861
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0021 0.0027
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0511 0.5626 0.8175
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0736 0.7895
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0021
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0114 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0114 0.0605
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0114 0.0301
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0021
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0044 0.0398 0.3012
Echinococcus granulosus dnaJ subfamily B 0.04 0.4381 0.4381
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.091 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.137 0.137
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0171 0.0848
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.386 0.4888
Loa Loa (eye worm) aminopeptidase N 0.0068 0.0666 0.0666
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0083 0.0005
Brugia malayi nuclear hormone receptor 0.0011 0.0021 0.003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0114 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Entamoeba histolytica hypothetical protein 0.0144 0.1515 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0277 0.0291
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.031 0.2177
Loa Loa (eye worm) hypothetical protein 0.009 0.091 0.091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0198 0.0407
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0114 0.0111
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0083 0.0005
Echinococcus granulosus importin 5 0.0016 0.0082 0.0082
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.03 0.0436
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0299 0.2075
Giardia lamblia Pyruvate kinase 0.0017 0.0095 0.0243
Trichomonas vaginalis set domain proteins, putative 0.0709 0.7846 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0152 0.013
Loa Loa (eye worm) hypothetical protein 0.0024 0.0171 0.0171
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0792 0.8781 0.8781
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0062 0.0599 0.5101
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0016 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0736 0.0736
Schistosoma mansoni hypothetical protein 0.0035 0.03 0.03
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0035 0.0299 0.2323
Echinococcus granulosus importin subunit beta 1 0.0084 0.0849 0.0849
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0144 0.1515 0.1515
Plasmodium falciparum thioredoxin reductase 0.0016 0.0083 0.0007
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0198 1
Toxoplasma gondii HEAT repeat-containing protein 0.0016 0.0082 0.0901
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.002 0.0126 0.042
Onchocerca volvulus Glucosylceramidase homolog 0.0335 0.3658 0.4663
Echinococcus multilocularis ferritin 0.0026 0.0198 0.0198
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0201 0.0201
Brugia malayi steroid hormone receptor 0.0011 0.0021 0.003
Brugia malayi FAT domain containing protein 0.0015 0.0076 0.011
Trichomonas vaginalis ferritin, putative 0.0026 0.0198 0.0189
Echinococcus multilocularis pyruvate kinase 0.0017 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0021
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0024 0.0171 0.1163
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.3658 0.4628
Echinococcus multilocularis pyruvate kinase 0.0017 0.0095 0.0095
Plasmodium falciparum glutathione reductase 0.0046 0.0421 0.4418
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0277 0.2357
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1578 0.1578
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0109 0.1128 1
Schistosoma mansoni hypothetical protein 0.0027 0.0201 0.0201
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0171 0.0171
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0736 0.0879
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0277 0.0277
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0623 0.3776
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Brugia malayi Peptidase family M1 containing protein 0.0068 0.0666 0.0967
Entamoeba histolytica protein kinase rad3, putative 0.002 0.0126 0.031
Trichomonas vaginalis esterase, putative 0.0074 0.0736 0.0879
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0062 0.0599 1
Loa Loa (eye worm) kap beta 3 protein 0.0016 0.0082 0.0082
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0018 0.0018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0114 0.006
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0623 0.0623
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0114 0.0114
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0114 0.0297
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.5626 0.7153
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0021
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0021 0.0021
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0267 0.0682
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0114 0.0114
Echinococcus granulosus dna polymerase kappa 0.0019 0.0114 0.0114
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0736 0.1271
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0076
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0087 0.0087
Echinococcus granulosus tumor protein p63 0.0351 0.3839 0.3839
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0018 0.0018
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1216 0.2205
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0044 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0042 0.0371 0.0371
Plasmodium falciparum glutathione reductase 0.0016 0.0083 0.0007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.091 0.091
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0736 0.2308
Trichomonas vaginalis hypothetical protein 0.0016 0.0082 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0126 0.0184
Echinococcus granulosus muscleblind protein 0.0149 0.1578 0.1578
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0144 0.1515 0.1515
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0021 0.003
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0068 0.0666 0.0666
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0299 0.0299
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0087 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0021 0.0021
Plasmodium falciparum importin beta, putative 0.0084 0.0849 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0095 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0021 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0126 0.0098
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0021 0.003
Entamoeba histolytica hypothetical protein 0.0144 0.1515 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0021 0.003
Leishmania major hypothetical protein, conserved 0.0074 0.0736 0.6248
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0114 0.0609
Schistosoma mansoni ferritin 0.0026 0.0198 0.0198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0074 0.0736 0.0736
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0021 0.003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0021 0.003
Echinococcus granulosus translational activator gcn1 0.0016 0.0082 0.0082
Trichomonas vaginalis importin beta-1, putative 0.0068 0.067 0.0795
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0666 0.0666
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1216 0.2205
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.031 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0114 0.0297
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0083 0.0041
Schistosoma mansoni hypothetical protein 0.0016 0.0087 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0021 0.0021
Echinococcus granulosus aminopeptidase N 0.0068 0.0666 0.0666
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.032 0.032
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0114 0.0605
Echinococcus granulosus protein quaking 0.0027 0.0201 0.0201
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0114 0.0609
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1084 0.1948
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0062 0.0599 0.4941
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0114 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0114 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Brugia malayi Pre-SET motif family protein 0.0623 0.6882 1
Brugia malayi nuclear receptor NHR-88 0.0011 0.0021 0.003
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0198 0.0224
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0035 0.0299 0.2075
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.5626 0.7153
Schistosoma mansoni thyroid hormone receptor 0.0141 0.1487 0.1487
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0114 0.011
Toxoplasma gondii HEAT repeat-containing protein 0.0016 0.0082 0.0901
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0736 0.6246
Loa Loa (eye worm) hypothetical protein 0.002 0.0126 0.0126
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0218 0.0218
Brugia malayi TATA binding protein associated factor 0.0024 0.0171 0.0249
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0171 0.1139
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0035 0.0299 0.2075
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0171 0.0848
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0021 0.0021
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1084 0.8706
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0068 0.067 0.0795
Giardia lamblia Pyruvate kinase 0.0033 0.0277 0.3767
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0171 0.1077
Trypanosoma brucei calpain-like protein, putative 0.0109 0.1128 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0087 0.0087
Schistosoma mansoni cpg binding protein 0.003 0.0235 0.0235
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0035 0.0299 0.0299
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0062 0.0599 0.6744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Schistosoma mansoni ap endonuclease 0.0019 0.0114 0.0114
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0164 0.0164
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0171 0.0848
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0114 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0114 0.0605
Echinococcus granulosus dna polymerase eta 0.0019 0.0114 0.0114
Echinococcus granulosus expressed protein 0.0026 0.0198 0.0198
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1084 0.1948
Entamoeba histolytica hypothetical protein 0.0144 0.1515 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0901 1 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0068 0.0666 0.5576
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.3658 0.4628
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0083 0.0083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0404 0.0404
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.031 0.0333
Schistosoma mansoni ran 0.0062 0.0599 0.0599
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.3658 0.4628
Loa Loa (eye worm) hypothetical protein 0.0044 0.0398 0.0398
Loa Loa (eye worm) hypothetical protein 0.0149 0.1578 0.1578
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0404 0.0404
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0035 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0068 0.067 0.0795
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0036 0.0052
Onchocerca volvulus 0.009 0.091 0.116
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0042 0.0371 0.2757
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0114 0.0165
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0083 0.0907
Leishmania major phosphatidylinositol kinase related protein, putative 0.0035 0.03 0.2082
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0126 0.0098
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0736 0.0736
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.031 0.0803
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0114 0.0114
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0109 0.1128 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0114 0.0605
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0035 0.0299 0.1516
Schistosoma mansoni glutaminase 0.0269 0.2913 0.2913
Plasmodium vivax glutathione reductase, putative 0.0046 0.0421 0.4092
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0021 0.0027
Loa Loa (eye worm) hypothetical protein 0.0024 0.0171 0.0171
Echinococcus multilocularis cpg binding protein 0.003 0.0235 0.0235
Schistosoma mansoni hypothetical protein 0.0016 0.0087 0.0087
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0114 0.0417
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0083 0.0317
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0623 0.5168
Echinococcus multilocularis importin 5 0.0016 0.0082 0.0082
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0623 0.0905
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0736 0.1271
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.1872 0.2386
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0114 0.0061
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0736 0.2308
Brugia malayi beta-lactamase 0.0074 0.0736 0.1069
Echinococcus multilocularis pyruvate kinase 0.0033 0.0277 0.0277
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0068 0.0666 0.0789
Leishmania major trypanothione reductase 0.0046 0.0421 0.3238
Schistosoma mansoni fkbp-rapamycin associated protein 0.002 0.0126 0.0126
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0021 0.0021
Loa Loa (eye worm) beta-lactamase 0.0074 0.0736 0.0736
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0484 0.0703
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0666 0.0666
Loa Loa (eye worm) importin-beta domain-containing protein 0.0016 0.0082 0.0082
Trypanosoma brucei trypanothione reductase 0.0046 0.0421 0.345
Brugia malayi beta-lactamase family protein 0.0074 0.0736 0.1069
Loa Loa (eye worm) hypothetical protein 0.0019 0.0114 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.091 0.091
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0021 0.003
Leishmania major pyruvate kinase 0.0033 0.0277 0.1865
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0021 0.0021
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0277 0.0277
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0114 0.0223
Mycobacterium tuberculosis Probable reductase 0.0105 0.1084 0.1948
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0068 0.0666 0.0666
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0114 0.0297
Onchocerca volvulus 0.0068 0.0666 0.0848
Loa Loa (eye worm) TATA binding protein associated factor 0.0024 0.0171 0.0171
Onchocerca volvulus 0.0011 0.0021 0.0027
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0277 0.0403
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0277 0.0353
Echinococcus granulosus leukotriene A 4 hydrolase 0.0024 0.0171 0.0171
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0496 0.5461 0.5461
Echinococcus granulosus hypothetical protein 0.0027 0.0201 0.0201
Onchocerca volvulus 0.0068 0.0666 0.0848
Trypanosoma brucei Aminopeptidase M1, putative 0.0068 0.0666 0.5716
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0021 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0016 0.0082 0.0313
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0171 0.0171
Echinococcus granulosus GTP binding nuclear protein Ran 0.0062 0.0599 0.0599
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0152 0.096
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0126 0.0098
Onchocerca volvulus 0.0028 0.0218 0.0277
Echinococcus multilocularis translational activator gcn1 0.0016 0.0082 0.0082
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0114 0.0301
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0666 0.0666
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0114 0.0605
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1084 0.1948
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0623 0.0623
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0035 0.0299 0.2323
Loa Loa (eye worm) hypothetical protein 0.0052 0.0484 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0021 0.003
Echinococcus granulosus serine protein kinase ATM 0.0049 0.0447 0.0447
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0083 0.0083
Schistosoma mansoni ferritin 0.0026 0.0198 0.0198
Brugia malayi Peptidase family M1 containing protein 0.0068 0.0666 0.0967
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0035 0.0299 0.0299
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0666 0.0666
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0475 0.5223 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0171 0.0853
Schistosoma mansoni aminopeptidase A (M01 family) 0.0024 0.0171 0.0171
Schistosoma mansoni hypothetical protein 0.0131 0.137 0.137
Loa Loa (eye worm) hypothetical protein 0.0074 0.0736 0.0736
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0479 0.0479
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0021
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0083 0.0317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Brugia malayi Inositol-1 0.0036 0.031 0.045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0114 0.0297
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0171 0.0249
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0068 0.0666 0.5716
Echinococcus multilocularis expressed protein 0.0026 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0051 0.0479 0.0479
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0736 0.1271
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0035 0.0299 0.2071
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0068 0.0666 0.0789
Loa Loa (eye worm) hypothetical protein 0.0023 0.0164 0.0164
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0277 0.0403
Echinococcus multilocularis pyruvate kinase 0.0026 0.0198 0.0198
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0087 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0024 0.0171 0.0171
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0049 0.0447 0.3486
Brugia malayi Temporarily assigned gene name protein 44 0.0027 0.0201 0.0292
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0421 0.0421
Loa Loa (eye worm) hypothetical protein 0.0074 0.0736 0.0736
Schistosoma mansoni ran 0.0062 0.0599 0.0599
Schistosoma mansoni importin beta-1 0.0084 0.0849 0.0849
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.091 0.091
Echinococcus granulosus pyruvate kinase 0.0017 0.0095 0.0095
Brugia malayi tumor suppressor. 0.0314 0.3424 0.4975
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0021 0.003
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0109 0.1128 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0021 0.003
Loa Loa (eye worm) hypothetical protein 0.0074 0.0736 0.0736
Chlamydia trachomatis pyruvate kinase 0.0033 0.0277 1
Echinococcus multilocularis muscleblind protein 0.0149 0.1578 0.1578
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.3658 0.4628
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0404 0.0404
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0164 0.0572
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0021 0.0021
Leishmania major DNA polymerase eta, putative 0.0019 0.0114 0.0302
Toxoplasma gondii FATC domain-containing protein 0.0049 0.0447 0.4912
Brugia malayi Muscleblind-like protein 0.0149 0.1578 0.2293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Loa Loa (eye worm) hypothetical protein 0.0024 0.0171 0.0171
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0267 0.0359
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0277 0.2119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0021 0.0021
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0062 0.0599 0.4941
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.031 0.031
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.031 0.0333
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0109 0.1128 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0152 0.0152
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.031 0.2422
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0015 0.0076 0.0076
Schistosoma mansoni apoferritin-2 0.0026 0.0198 0.0198
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0018 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.091 0.091
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0015 0.0076 0.0076
Echinococcus granulosus pyruvate kinase 0.0033 0.0277 0.0277
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0035 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Echinococcus multilocularis pyruvate kinase 0.0033 0.0277 0.0277
Echinococcus granulosus pyruvate kinase 0.0033 0.0277 0.0277
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0083 0.0005
Onchocerca volvulus 0.0074 0.0736 0.0938
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0114 0.0302
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0736 0.1271
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.0171 0.0313
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.031 0.159
Schistosoma mansoni hypothetical protein 0.0016 0.0087 0.0087
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0021 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.3658 0.4628
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1084 0.1948
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0666 0.0666
Echinococcus granulosus ferritin 0.0026 0.0198 0.0198
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0299 0.2323
Echinococcus multilocularis protein quaking 0.0027 0.0201 0.0201
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0736 0.0736
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0021 0.003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0021 0.0021
Trypanosoma cruzi Aminopeptidase M1, putative 0.0068 0.0666 0.5576
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0666 0.0666
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0095 0.1045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Brugia malayi glutathione reductase 0.0046 0.0421 0.0611
Schistosoma mansoni cpg binding protein 0.003 0.0235 0.0235
Echinococcus multilocularis importin subunit beta 1 0.0084 0.0849 0.0849
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0083 0.0005
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0035 0.0299 0.2323
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0087 0.0126
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0198 0.5072
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.3658 0.4628
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0736 0.0736
Mycobacterium tuberculosis Conserved protein 0.0074 0.0736 0.1271
Brugia malayi hypothetical protein 0.0024 0.0171 0.0249
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0021 0.0021
Echinococcus multilocularis transportin 1 0.0016 0.0082 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0021 0.0021
Trypanosoma brucei Aminopeptidase M1, putative 0.0068 0.0666 0.5716
Schistosoma mansoni ferritin light chain 0.0026 0.0198 0.0198
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0299 0.2071
Onchocerca volvulus 0.0051 0.0479 0.0611
Brugia malayi hypothetical protein 0.0068 0.0666 0.0967
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0083 0.0006
Brugia malayi Pre-SET motif family protein 0.009 0.091 0.1322
Echinococcus multilocularis pyruvate kinase 0.0017 0.0095 0.0095
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0114 0.1384
Echinococcus granulosus transportin 1 0.0016 0.0082 0.0082
Mycobacterium ulcerans beta-lactamase 0.0074 0.0736 0.2308
Trypanosoma cruzi aminopeptidase, putative 0.0068 0.0666 0.5576
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0171 0.0848
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0021 0.0021
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0049 0.0447 0.0447
Echinococcus multilocularis GPCR, family 2 0.0016 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0496 0.5461 0.5461
Loa Loa (eye worm) glutaminase 0.0269 0.2913 0.2913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0114 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0083 0.0907
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0021 0.0021
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0035 0.0299 0.2071
Plasmodium falciparum thioredoxin reductase 0.0046 0.0421 0.4418
Entamoeba histolytica hypothetical protein 0.0068 0.067 0.4105
Mycobacterium tuberculosis Conserved protein 0.0074 0.0736 0.1271
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0277 0.0277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0299 0.0319
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0021 0.0021
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.031 0.0333
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0062 0.0599 0.6246
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0277 0.0688
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0083 0.0317
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0114 0.0166
Schistosoma mansoni apoferritin-2 0.0026 0.0198 0.0198
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0114 0.0082
Echinococcus granulosus cpg binding protein 0.003 0.0235 0.0235
Mycobacterium ulcerans lipase LipD 0.0074 0.0736 0.2308
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0035 0.0299 0.2323
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0035 0.0299 0.1516
Brugia malayi kap beta 3 protein 0.0016 0.0082 0.0119
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0018 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.5626 0.7153
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0198 0.0224
Toxoplasma gondii aminopeptidase N protein 0.0024 0.0171 0.1881
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0037 0.0037
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0044 0.0398 0.0398
Mycobacterium tuberculosis Conserved protein 0.0074 0.0736 0.1271
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0114 0.0114
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0277 0.1861
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0171 0.0848
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0021 0.0021
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0114 0.0605
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0736 0.5284
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0035 0.0299 0.2071
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0024 0.0171 0.0171
Brugia malayi RNA, U transporter 1 0.024 0.2593 0.3767
Brugia malayi hypothetical protein 0.0144 0.1515 0.2201
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0421 0.0658
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0736 0.1271
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0074 0.0736 0.0736
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0024 0.0171 0.0171
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0404 0.0404
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0037 0.0037
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.137 0.137
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0021 0.0027
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0299 0.0299
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0623 0.5168
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0021 0.003
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0421 0.0421
Entamoeba histolytica hypothetical protein 0.0049 0.0447 0.2548
Onchocerca volvulus 0.0074 0.0736 0.0938
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0126 0.0098
Brugia malayi ecdysteroid receptor 0.0011 0.0021 0.003
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0021 0.0021
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0109 0.1128 1
Schistosoma mansoni thyroid hormone receptor 0.0141 0.1487 0.1487
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0024 0.0171 0.1163
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0095 0.0158
Onchocerca volvulus 0.0024 0.0171 0.0218
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0736 0.1069
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0404 0.0587
Echinococcus multilocularis serine protein kinase ATM 0.0049 0.0447 0.0447
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0021 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.386 0.4888

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.