Detailed information for compound 729531

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 384.874 | Formula: C22H22ClFN2O
  • H donors: 0 H acceptors: 1 LogP: 4.05 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)CN1C[C@H]2[C@]3(C1=O)CCCN3[C@@H](C2)c1ccccc1F
  • InChi: 1S/C22H22ClFN2O/c23-17-6-3-5-15(11-17)13-25-14-16-12-20(18-7-1-2-8-19(18)24)26-10-4-9-22(16,26)21(25)27/h1-3,5-8,11,16,20H,4,9-10,12-14H2/t16-,20-,22-/m0/s1
  • InChiKey: NYUDBOCWGIOCIM-BUKVSMQUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0039 0.0385 0.0317
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0342 0.0974
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.073 0.0713
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0751 0.0734
Schistosoma mansoni hypothetical protein 0.0181 0.2344 0.2338
Entamoeba histolytica hypothetical protein 0.0038 0.0381 0.2959
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0564 0.0556
Schistosoma mansoni tsg101-related 0.0051 0.0547 0.054
Mycobacterium tuberculosis Conserved protein 0.0039 0.0385 0.0317
Toxoplasma gondii exonuclease III APE 0.002 0.0128 0.1488
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0385 0.0368
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0385 0.1103
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0128 0.011
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0561 0.1685
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0291 0.3707
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0399 0.0391
Echinococcus granulosus kelch ECH associated protein 1 0.0101 0.124 0.1225
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0102 0.0095
Echinococcus multilocularis microtubule associated protein 2 0.0738 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0529 0.0522
Trichomonas vaginalis esterase, putative 0.0039 0.0385 0.1103
Echinococcus multilocularis chromobox protein 1 0.0074 0.0876 0.086
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0084 0.0251
Brugia malayi mbt repeat family protein 0.0052 0.0564 0.1693
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0403 0.1157
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0102 0.0084
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0662 0.0645
Schistosoma mansoni inositol monophosphatase 0.004 0.0403 0.0396
Echinococcus granulosus kelch ECH associated protein 1 like 0.0101 0.124 0.1225
Schistosoma mansoni zinc finger protein 0.0021 0.0139 0.0132
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0084 0.0066
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0385 1
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1241 0.3684
Onchocerca volvulus 0.0253 0.3335 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0797 0.079
Loa Loa (eye worm) hypothetical protein 0.0039 0.0385 0.1105
Brugia malayi intermediate filament protein 0.0029 0.0248 0.0745
Entamoeba histolytica hypothetical protein 0.0038 0.0381 0.2959
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0342 0.0976
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0342 0.0264
Echinococcus multilocularis muscleblind protein 0.0161 0.2065 0.205
Schistosoma mansoni hypothetical protein 0.0052 0.0561 0.0553
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.028 0.0263
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0019 0.0001
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0564 0.0547
Loa Loa (eye worm) hypothetical protein 0.0028 0.0241 0.067
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0385 0.0054
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0342 0.2623
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.028 0.0273
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0399 0.1146
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0385 0.0317
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0751 0.5795
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0342 0.8829
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0403 0.0386
Echinococcus multilocularis chromobox protein 1 0.0074 0.0876 0.086
Echinococcus multilocularis kelch ECH associated protein 1 0.0101 0.124 0.1225
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0564 0.1642
Echinococcus granulosus chromobox protein 1 0.0074 0.0876 0.086
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0385 0.0377
Onchocerca volvulus 0.0039 0.0385 0.1103
Toxoplasma gondii ABC1 family protein 0.0039 0.0385 0.4997
Echinococcus multilocularis lamin dm0 0.0029 0.0248 0.0231
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0385 0.0377
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0541 0.0524
Loa Loa (eye worm) hypothetical protein 0.0033 0.0302 0.0854
Brugia malayi RNA binding protein 0.0069 0.0797 0.2395
Schistosoma mansoni hypothetical protein 0.0181 0.2344 0.2338
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0458 0.0451
Loa Loa (eye worm) hypothetical protein 0.0074 0.0874 0.2583
Echinococcus multilocularis zinc finger protein 0.0021 0.0139 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0385 0.2975
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0403 0.3123
Schistosoma mansoni hypothetical protein 0.0012 0.0019 0.0011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0385 0.0317
Loa Loa (eye worm) hypothetical protein 0.0046 0.0479 0.1388
Mycobacterium ulcerans hypothetical protein 0.0039 0.0385 0.0317
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0155 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0426 0.1226
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.073 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0426 0.1226
Schistosoma mansoni hypothetical protein 0.0017 0.0084 0.0076
Loa Loa (eye worm) hypothetical protein 0.0039 0.0385 0.1105
Loa Loa (eye worm) hypothetical protein 0.0059 0.0662 0.1943
Loa Loa (eye worm) hypothetical protein 0.0041 0.0416 0.1198
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0403 0.0339
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0385 0.0317
Schistosoma mansoni pyruvate kinase 0.0036 0.0342 0.0335
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0385 0.2975
Giardia lamblia Kinase, PLK 0.0101 0.1241 1
Plasmodium falciparum phd finger protein, putative 0.0031 0.028 0.8085
Echinococcus multilocularis pyruvate kinase 0.0036 0.0342 0.0325
Schistosoma mansoni inositol monophosphatase 0.004 0.0403 0.0396
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0019 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1241 0.3684
Loa Loa (eye worm) hypothetical protein 0.019 0.2462 0.738
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0751 0.0769
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0128 0.0443
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0128 0.0385
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0128 0.5
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0564 0.0547
Trypanosoma cruzi ISWI complex protein 0.0016 0.0077 0.0443
Loa Loa (eye worm) hypothetical protein 0.0029 0.0248 0.0692
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0797 0.2351
Echinococcus granulosus Chromobox protein 3 0.0012 0.0019 0.0001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0426 0.1229
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0019 0.0001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0403 0.3123
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0797 0.079
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0822 0.6565
Loa Loa (eye worm) hypothetical protein 0.0253 0.3329 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0208 0.2714 0.2701
Echinococcus granulosus pyruvate kinase 0.0018 0.0103 0.0085
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0822 0.0815
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0103 0.2605
Loa Loa (eye worm) hypothetical protein 0.0044 0.0451 0.1303
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0797 0.079
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0385 0.1103
Trypanosoma cruzi ISWI complex protein 0.0016 0.0077 0.0443
Schistosoma mansoni zinc finger protein 0.0016 0.0077 0.0069
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.3329 0.3317
Brugia malayi PHD-finger family protein 0.0027 0.0218 0.0655
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.028 0.0263
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0183 0.0165
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0413 0.0396
Loa Loa (eye worm) hypothetical protein 0.0039 0.0385 0.1105
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0342 0.0974
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0448 0.0431
Loa Loa (eye worm) beta-lactamase 0.0039 0.0385 0.1105
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.2912 0.874
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0043 0.0025
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0342 0.0976
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0342 0.0976
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0876 0.2584
Giardia lamblia Pyruvate kinase 0.0036 0.0342 0.2099
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.038 0.0363
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.1241 0.1225
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0128 0.011
Schistosoma mansoni microtubule-associated protein tau 0.0738 1 1
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0074 0.0874 0.0858
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0403 0.3142
Brugia malayi jmjC domain containing protein 0.004 0.0399 0.1197
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0047 0.004
Brugia malayi hypothetical protein 0.0012 0.0019 0.0058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0751 0.0769
Brugia malayi mbt repeat family protein 0.0052 0.0564 0.1693
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0662 0.199
Schistosoma mansoni lamin 0.0029 0.0248 0.024
Schistosoma mansoni ap endonuclease 0.002 0.0128 0.012
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0342 0.0974
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0529 0.0522
Schistosoma mansoni hypothetical protein 0.0031 0.028 0.0273
Brugia malayi Bromodomain containing protein 0.008 0.0955 0.2867
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0128 0.0866
Entamoeba histolytica hypothetical protein 0.0038 0.0381 0.2959
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.1241 1
Echinococcus multilocularis kelch ECH associated protein 1 0.0101 0.124 0.1225
Loa Loa (eye worm) inositol-1 0.004 0.0403 0.116
Schistosoma mansoni tsg101-related 0.0062 0.0703 0.0696
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.019 0.2462 0.7366
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0751 0.0744
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0381 0.0373
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1241 0.3684
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0751 0.0769
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0291 0.0273
Entamoeba histolytica hypothetical protein 0.0012 0.0023 0.0028
Brugia malayi Pre-SET motif family protein 0.0222 0.2912 0.8748
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0564 0.0547
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0385 0.1103
Brugia malayi Bromodomain containing protein 0.0034 0.0315 0.0947
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0102 0.0095
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0342 0.2623
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0342 0.2623
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.1241 0.3727
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0128 0.0218
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.1241 1
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0967 0.096
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0342 0.1028
Schistosoma mansoni hypothetical protein 0.0036 0.0353 0.0345
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0111 0.0278
Leishmania major hypothetical protein, conserved 0.0024 0.0179 0.0877
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0342 0.2623
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0609 0.8229 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0403 1
Brugia malayi jmjC domain containing protein 0.0102 0.1256 0.3772
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0248 0.0692
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0036 0.0108
Loa Loa (eye worm) RNA binding protein 0.0069 0.0797 0.2351
Leishmania major hypothetical protein, conserved 0.0039 0.0385 0.2649
Schistosoma mansoni hypothetical protein 0.0017 0.0084 0.0076
Loa Loa (eye worm) hypothetical protein 0.0036 0.0353 0.1007
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0797 0.2395
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0385 0.1156
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0183 0.0165
Giardia lamblia PHD finger protein 15 0.0031 0.028 0.1556
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0403 0.0386
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0797 0.079
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0128 0.0328
Brugia malayi Inositol-1 0.004 0.0403 0.1211
Echinococcus multilocularis pyruvate kinase 0.0018 0.0103 0.0085
Echinococcus multilocularis pyruvate kinase 0.0018 0.0103 0.0085
Schistosoma mansoni chromobox protein 0.0074 0.0876 0.0869
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0023 0.001
Echinococcus granulosus lamin dm0 0.0029 0.0248 0.0231
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0103 0.23
Loa Loa (eye worm) hypothetical protein 0.0053 0.0587 0.1714
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0797 0.0781
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0539 0.1568
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0797 0.079
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0737 0.2168
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0043 0.0025
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.3329 0.3317
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.1256 0.124
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.1241 0.369
Echinococcus granulosus lamin 0.0029 0.0248 0.0231
Brugia malayi CHD4 protein 0.0014 0.0047 0.0142
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0274 0.0257
Brugia malayi Heterochromatin protein 1 0.0074 0.0876 0.2632
Brugia malayi beta-lactamase family protein 0.0039 0.0385 0.1156
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1241 0.3684
Echinococcus multilocularis chromobox protein 2 0.0012 0.0019 0.0001
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0064 0.0192
Schistosoma mansoni chromobox protein 0.0012 0.0019 0.0011
Echinococcus multilocularis Kelch repeat type 1 0.0101 0.1244 0.1229
Schistosoma mansoni hypothetical protein 0.0022 0.0155 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0258 0.0721
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0662 0.0645
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.005
Loa Loa (eye worm) hypothetical protein 0.005 0.0541 0.1577
Chlamydia trachomatis pyruvate kinase 0.0036 0.0342 0.5
Schistosoma mansoni hypothetical protein 0.0017 0.0084 0.0076
Onchocerca volvulus 0.0052 0.0564 0.1642
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0019 0.0011
Loa Loa (eye worm) hypothetical protein 0.0052 0.0564 0.1645
Schistosoma mansoni lamin 0.0029 0.0248 0.024
Loa Loa (eye worm) hypothetical protein 0.0025 0.0194 0.0527
Brugia malayi hypothetical protein 0.0253 0.3329 1
Echinococcus granulosus pyruvate kinase 0.0036 0.0342 0.0325
Loa Loa (eye worm) hypothetical protein 0.0039 0.0385 0.1105
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0128 0.0891
Schistosoma mansoni hypothetical protein 0.0319 0.4237 0.4233
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0194 0.0527
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0019 0.0001
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0019 0.0011
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0609 0.8229 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0385 0.1105
Brugia malayi Bromodomain containing protein 0.0041 0.0415 0.1246
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0541 0.0534
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0248 0.0745
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0381 0.0363
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0183 0.0175
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0103 0.1149
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0291 0.0283
Echinococcus multilocularis musashi 0.0029 0.0248 0.0231
Onchocerca volvulus 0.0012 0.0019 0.000000055456
Echinococcus multilocularis pyruvate kinase 0.0028 0.0239 0.0221
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.1241 1
Plasmodium vivax SET domain protein, putative 0.0032 0.0291 0.7418
Onchocerca volvulus 0.0033 0.0302 0.0852
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0128 0.0328
Onchocerca volvulus 0.0039 0.0385 0.1103
Trypanosoma brucei polo-like protein kinase 0.0101 0.1241 1
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0024 0.0179 0.1281
Brugia malayi N-terminal motif family protein 0.019 0.2462 0.7395
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0353 0.1059
Schistosoma mansoni bromodomain containing protein 0.0068 0.0782 0.0775
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0876 0.2589
Entamoeba histolytica hypothetical protein 0.0012 0.0023 0.0028
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0385 0.1105
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0342 0.0264
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0751 1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0751 0.0744
Echinococcus granulosus geminin 0.0181 0.2344 0.233
Mycobacterium ulcerans lipase LipD 0.0039 0.0385 0.0317
Echinococcus multilocularis muscleblind protein 1 0.0161 0.2065 0.205
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0448 0.0431
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0564 0.1645
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0074 0.0874 0.0858
Brugia malayi Muscleblind-like protein 0.0161 0.2065 0.6202
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0385 0.0317
Leishmania major pyruvate kinase 0.0036 0.0342 0.2281
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0342 0.4412
Echinococcus granulosus muscleblind protein 0.0161 0.2065 0.205
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0342 0.0974
Echinococcus granulosus chromobox protein 1 0.0074 0.0876 0.086
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0019 0.0058
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0564 0.0556
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0541 0.0534
Echinococcus granulosus GPCR family 2 0.0017 0.0084 0.0066
Entamoeba histolytica hypothetical protein 0.0012 0.0023 0.0028
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0822 0.247
Onchocerca volvulus 0.0039 0.0385 0.1103
Brugia malayi beta-lactamase family protein 0.0039 0.0385 0.1156
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0529 0.0512
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0208 0.2714 0.2701
Echinococcus granulosus zinc finger protein 0.0021 0.0139 0.0122
Onchocerca volvulus 0.0029 0.0248 0.069
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0876 0.2584
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0399 0.0391
Loa Loa (eye worm) hypothetical protein 0.0039 0.0385 0.1105
Plasmodium falciparum pyruvate kinase 0.0036 0.0342 1
Brugia malayi hypothetical protein 0.0038 0.0381 0.1143
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0564 0.0547
Mycobacterium leprae Probable lipase LipE 0.0039 0.0385 0.0054
Schistosoma mansoni hypothetical protein 0.0016 0.0077 0.0069
Schistosoma mansoni kinase 0.0051 0.0558 0.055
Echinococcus granulosus tar DNA binding protein 0.0069 0.0797 0.0781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0529 0.0512
Schistosoma mansoni ap endonuclease 0.002 0.0128 0.012
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0385 0.0368
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0002
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.1241 0.3684
Brugia malayi Protein cec-1. 0.0012 0.0019 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0031 0.028 0.7138
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0371 0.0353
Loa Loa (eye worm) hypothetical protein 0.0161 0.2065 0.618
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0564 0.0556
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.1241 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0541 0.0524
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0342 0.1028
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.1241 0.1225
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0128 0.3372
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0019 0.0058
Schistosoma mansoni hypothetical protein 0.0017 0.0084 0.0076
Schistosoma mansoni chromobox protein 0.0012 0.0019 0.0011
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0662 0.0645
Echinococcus multilocularis GPCR, family 2 0.0017 0.0084 0.0066
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0102 0.0084
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.028 0.3567
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0403 0.1157
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0128 0.0866
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0822 0.2426
Schistosoma mansoni hypothetical protein 0.0101 0.1244 0.1237
Echinococcus granulosus pyruvate kinase 0.0036 0.0342 0.0325
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0822 0.0806
Brugia malayi beta-lactamase 0.0039 0.0385 0.1156
Trichomonas vaginalis hypothetical protein 0.0036 0.035 0.0996
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0345 0.0004
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0051 0.0547 0.4322
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0822 0.6565
Mycobacterium ulcerans beta-lactamase 0.0039 0.0385 0.0317
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0426 0.1226
Brugia malayi PHD-finger family protein 0.0012 0.002 0.0059
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0385 0.0317
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.028 0.0789
Loa Loa (eye worm) MBCTL1 0.0059 0.0662 0.1943
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.1241 0.1234
Echinococcus multilocularis pyruvate kinase 0.0036 0.0342 0.0325
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0822 0.6575
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0194 0.1428
Schistosoma mansoni chromobox protein 0.0074 0.0876 0.0869
Schistosoma mansoni pyruvate kinase 0.0036 0.0342 0.0335
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0084 0.0251
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0585 0.1756
Leishmania major pyruvate kinase 0.0036 0.0342 0.2281
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1241 0.3684
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1241 0.3684
Trichomonas vaginalis set domain proteins, putative 0.0253 0.3335 1
Schistosoma mansoni intermediate filament proteins 0.0029 0.0248 0.024
Echinococcus multilocularis geminin 0.0181 0.2344 0.233
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0585 0.1708
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0822 0.6565
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0751 0.0769
Brugia malayi hypothetical protein 0.0074 0.0874 0.2626
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1241 0.3684
Mycobacterium tuberculosis Conserved protein 0.0039 0.0385 0.0317
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0662 0.0655
Echinococcus granulosus peregrin 0.0034 0.0315 0.0298
Schistosoma mansoni tsg101-related 0.0062 0.0703 0.0696
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0381 0.0363
Brugia malayi PHD-finger family protein 0.0031 0.028 0.0842
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0064 0.0135
Brugia malayi Pre-SET motif family protein 0.0032 0.0291 0.0873
Loa Loa (eye worm) hypothetical protein 0.0053 0.0585 0.1708
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0529 0.159
Schistosoma mansoni hypothetical protein 0.0038 0.0381 0.0373
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0403 0.2805
Brugia malayi SET domain containing protein 0.0013 0.0035 0.0106
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0385 0.0317
Onchocerca volvulus Alhambra homolog 0.0031 0.028 0.0787
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0751 0.0734
Echinococcus multilocularis Chromo domain 0.0012 0.0019 0.0001
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0399 0.0381
Onchocerca volvulus 0.0044 0.0458 0.1324
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0822 0.6406
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.005
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0385 0.0317
Echinococcus multilocularis lamin 0.0029 0.0248 0.0231
Echinococcus granulosus chromobox protein 2 0.0012 0.0019 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0084 0.0194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0529 0.0512
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0403 0.5244
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0413 0.0396
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0342 0.0976
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0385 0.1103
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0128 0.0866
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0385 0.2975
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0342 0.0974
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0258 0.0721
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0385 0.0317
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0047 0.0029
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0385 0.0317
Schistosoma mansoni survival motor neuron protein 0.0052 0.0561 0.0553
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.3259 0.3866
Echinococcus multilocularis peregrin 0.0034 0.0315 0.0298
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0128 0.2977
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0019 0.0058
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0047 0.0085
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.1256 0.124
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0084 0.0066
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0385 0.1103
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0529 0.0512
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0529 0.0522
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0403 0.1157
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0609 0.8229 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0019 0.0011
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0248 0.0692
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0822 0.0806
Onchocerca volvulus 0.0029 0.0248 0.069
Brugia malayi chromobox protein homolog 3 0.0042 0.0426 0.1279
Entamoeba histolytica hypothetical protein 0.0038 0.0381 0.2959
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0662 0.0645
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0084 0.0066
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.038 0.0363
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0403 0.3123
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0797 0.2351
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.028 0.3567
Trypanosoma brucei ISWI complex protein 0.0016 0.0077 0.0443
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0585 0.1756
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0529 0.1541
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0072
Echinococcus granulosus intermediate filament protein 0.0029 0.0248 0.0231
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.047 0.1358
Trichomonas vaginalis chromobox protein, putative 0.0045 0.047 0.1358
Echinococcus granulosus Chromo domain 0.0012 0.0019 0.0001
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0345 0.0268
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0539 0.1568
Echinococcus multilocularis pyruvate kinase 0.0018 0.0103 0.0085
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0128 0.0329
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0084 0.0066
Loa Loa (eye worm) hypothetical protein 0.0161 0.2065 0.618
Trichomonas vaginalis chromobox protein, putative 0.0045 0.047 0.1358
Entamoeba histolytica hypothetical protein 0.0012 0.0023 0.0028
Echinococcus granulosus pyruvate kinase 0.0018 0.0103 0.0085
Schistosoma mansoni pyruvate kinase 0.0018 0.0103 0.0096
Echinococcus granulosus pyruvate kinase 0.0018 0.0103 0.0085
Loa Loa (eye worm) hypothetical protein 0.0031 0.028 0.0789
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0024 0.0179 0.1281
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0047 0.0029
Echinococcus granulosus kelch ECH associated protein 1 like 0.0101 0.124 0.1225
Onchocerca volvulus 0.0052 0.0561 0.1633
Brugia malayi TAR-binding protein 0.0069 0.0797 0.2395
Loa Loa (eye worm) hypothetical protein 0.0076 0.0892 0.2636

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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