Detailed information for compound 732235

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.527 | Formula: C23H33N3O2
  • H donors: 0 H acceptors: 1 LogP: 2.79 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCN1CCC(CC1)CN(Cc1ccc(cc1)OC)Cc1ccncc1
  • InChi: 1S/C23H33N3O2/c1-27-16-15-25-13-9-22(10-14-25)19-26(18-21-7-11-24-12-8-21)17-20-3-5-23(28-2)6-4-20/h3-8,11-12,22H,9-10,13-19H2,1-2H3
  • InChiKey: RZCPGCKEKNVYFF-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0271 0.1027
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Trypanosoma cruzi histidyl-tRNA synthetase 0.0008 0.0017 0.0195
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0104 0.012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.027 0.0358
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0044 0.0049
Loa Loa (eye worm) hypothetical protein 0.0067 0.0649 0.2474
Brugia malayi isocitrate dehydrogenase 0.0016 0.0104 0.0389
Leishmania major hypothetical protein, conserved 0.0031 0.0271 0.351
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0136 0.0531
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Plasmodium falciparum mitogen-activated protein kinase 2 0.0361 0.3768 0.3767
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0185 0.2392
Loa Loa (eye worm) hypothetical protein 0.0049 0.0455 0.1731
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0013 0.0071 0.0892
Plasmodium vivax CDK-related protein kinase 6, putative 0.0949 1 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.0348 0.1359
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0044 0.0056
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0224 0.2308 0.2713
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.001 0.0009
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0017 0.0019
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.001 0.0099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0673 0.265
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0348 0.1322
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0008 0.0017 0.0017
Echinococcus multilocularis survival motor neuron protein 1 0.0252 0.2614 0.3073
Echinococcus multilocularis solute carrier family 22 0.0031 0.0271 0.0316
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0011 0.0055 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0014
Schistosoma mansoni sugar transporter 0.0031 0.0271 0.0359
Echinococcus granulosus Threonyl tRNA synthetase C 0.0013 0.0071 0.0091
Loa Loa (eye worm) hypothetical protein 0.0034 0.0297 0.1128
Echinococcus multilocularis solute carrier family 22 0.0031 0.0271 0.0316
Leishmania major hypothetical protein, conserved 0.0039 0.0348 0.4519
Onchocerca volvulus 0.0031 0.0271 0.106
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.005 0.0467 0.7182
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0112 0.0439
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.001 0.0029
Schistosoma mansoni hypothetical protein 0.0016 0.0104 0.0136
Loa Loa (eye worm) hypothetical protein 0.0055 0.0515 0.1964
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0008 0.0017 0.016
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0104 0.133
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.005 0.0467 0.1835
Echinococcus multilocularis histidyl tRNA synthetase 0.0008 0.0017 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0348 0.4519
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Schistosoma mansoni histidyl-tRNA synthetase 0.0008 0.0017 0.002
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0348 0.1322
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0017 0.0019
Schistosoma mansoni sugar transporter 0.0031 0.0271 0.0359
Schistosoma mansoni ap endonuclease 0.0019 0.0136 0.0178
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0123 0.2464
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0044 0.0049
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0136 0.1746
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.001 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0348 0.0462
Plasmodium falciparum calcium-dependent protein kinase 5 0.0069 0.0664 0.0661
Loa Loa (eye worm) oxidoreductase 0.0007 0.001 0.0029
Chlamydia trachomatis histidine--tRNA ligase 0.0008 0.0017 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0159
Plasmodium falciparum calcium-dependent protein kinase 4 0.0069 0.0664 0.0661
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0044 0.0159
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.0387 0.1511
Onchocerca volvulus 0.0031 0.0271 0.106
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0017 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0044 0.0159
Plasmodium falciparum calcium-dependent protein kinase 1 0.0069 0.0664 0.0661
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0348 0.1359
Echinococcus granulosus GPCR family 2 0.0016 0.0104 0.0136
Onchocerca volvulus 0.0049 0.0455 0.1788
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0464 0.1766
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0025 0.0026
Echinococcus granulosus geminin 0.0169 0.1727 0.2307
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0044 0.0056
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0251 0.0333
Loa Loa (eye worm) hypothetical protein 0.0039 0.0348 0.1322
Schistosoma mansoni hypothetical protein 0.0051 0.0483 0.0643
Onchocerca volvulus 0.0039 0.0348 0.1365
Toxoplasma gondii sugar transporter ST2 0.0031 0.0271 0.0404
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0006 0.0003 0.001
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0031 0.0271 0.351
Echinococcus granulosus calcium dependent protein kinase 0.0064 0.0618 0.0824
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0185 0.3838
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0123 0.012
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.001 0.0099
Loa Loa (eye worm) hypothetical protein 0.0007 0.001 0.0029
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0348 0.1365
Schistosoma mansoni microtubule-associated protein tau 0.0711 0.7474 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Trypanosoma brucei glucose transporter, putative 0.0069 0.0673 0.8771
Echinococcus granulosus dnaJ subfamily B 0.0407 0.4256 0.5693
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0044 0.0056
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.004
Loa Loa (eye worm) hypothetical protein 0.005 0.0464 0.1766
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0031 0.0271 0.0268
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0348 0.7398
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0185 0.3838
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0067 0.0649 0.2474
Onchocerca volvulus 0.0031 0.0271 0.106
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0044 0.0159
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0185 0.2392
Echinococcus granulosus solute carrier family 22 0.0031 0.0271 0.0359
Mycobacterium leprae conserved hypothetical protein 0.0011 0.0055 0.0815
Echinococcus granulosus cpg binding protein 0.003 0.0258 0.0342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0044 0.0159
Mycobacterium tuberculosis Conserved protein 0.0039 0.0348 0.1359
Leishmania major myo-inositol/proton symporter (MIT) 0.0031 0.0271 0.351
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.001 0.004
Leishmania major hypothetical protein, conserved 0.0011 0.0055 0.0689
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0044 0.0056
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0104 0.0153
Trypanosoma cruzi hexose transporter, putative 0.0069 0.0673 0.8771
Onchocerca volvulus 0.0031 0.0271 0.106
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.001 0.003
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0044 0.0159
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0024 0.0189 0.391
Giardia lamblia Aspartyl-tRNA synthetase 0.0008 0.0017 0.0225
Onchocerca volvulus 0.0051 0.0483 0.1901
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0104 0.012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0044 0.0159
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0013 0.0071 0.2114
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0123 0.0479
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0008 0.0017 0.0059
Schistosoma mansoni hypothetical protein 0.0016 0.0104 0.0136
Leishmania major asparaginyl-tRNA synthetase, putative 0.0008 0.0017 0.019
Trypanosoma brucei sugar transporter, putative 0.0031 0.0271 0.351
Trichomonas vaginalis sugar transporter, putative 0.0069 0.0673 0.265
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.004
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0271 0.1027
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0017 0.0019
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Schistosoma mansoni sugar transporter 0.0031 0.0271 0.0359
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.001 0.004
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0044 0.0159
Schistosoma mansoni coup transcription factor 0.001 0.0044 0.0056
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0008 0.0017 0.0014
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0008 0.0017 0.02
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0069 0.0664 0.0997
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0104 0.0119
Echinococcus granulosus solute carrier family 22 0.0031 0.0271 0.0359
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0112 0.0439
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.0014
Onchocerca volvulus 0.0029 0.0241 0.0941
Trypanosoma cruzi hexose transporter, putative 0.0069 0.0673 0.8771
Loa Loa (eye worm) hypothetical protein 0.005 0.0467 0.1777
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0013 0.0071 0.0261
Brugia malayi ecdysteroid receptor 0.001 0.0044 0.0159
Loa Loa (eye worm) hypothetical protein 0.0067 0.0649 0.2474
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0044 0.0056
Giardia lamblia Sugar-proton symporter 0.0031 0.0271 0.415
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0078 0.0766 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0044 0.0159
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0348 0.1359
Echinococcus granulosus microtubule associated protein 2 0.0711 0.7474 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.0467 1
Echinococcus multilocularis cpg binding protein 0.003 0.0258 0.03
Echinococcus granulosus lysyl tRNA synthetase 0.005 0.0467 0.0621
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0136 0.0527
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.001 0.0029
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0031 0.0271 0.1057
Brugia malayi Sugar transporter family protein 0.0224 0.2308 0.8831
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0008 0.0017 0.0017
Echinococcus granulosus solute carrier family 22 0.0031 0.0271 0.0359
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0044 0.0159
Giardia lamblia Threonyl-tRNA synthetase 0.0013 0.0071 0.1055
Schistosoma mansoni ap endonuclease 0.0019 0.0136 0.0178
Schistosoma mansoni protein kinase 0.0068 0.0663 0.0884
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0044 0.0049
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0224 0.2308 0.3086
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0747 0.0876
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.001 0.0099
Trichomonas vaginalis sugar transport protein, putative 0.0031 0.0271 0.106
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0348 0.1359
Leishmania major threonyl-tRNA synthetase, putative 0.0013 0.0071 0.0892
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0042 0.0151
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.027 0.0358
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0025 0.0026
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0747 0.0997
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0348 0.1359
Echinococcus multilocularis glycyl tRNA synthetase 0.0013 0.0071 0.008
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.001 0.004
Onchocerca volvulus 0.0031 0.0271 0.106
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0159
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.046
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0185 0.07
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0044 0.0056
Leishmania major protein kinase, putative 0.0068 0.0663 0.865
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0348 0.1359
Toxoplasma gondii ABC1 family protein 0.0039 0.0348 0.052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.027 0.0358
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0068 0.0663 0.2531
Plasmodium vivax proline--tRNA ligase, putative 0.0078 0.0766 0.0764
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0014
Echinococcus granulosus General substrate transporter 0.0192 0.1975 0.264
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0044 0.0159
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0104 0.0102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.0014
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0464 0.1766
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0067 0.0649 0.2555
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0348 0.0462
Brugia malayi Sugar transporter family protein 0.0031 0.0271 0.1027
Loa Loa (eye worm) sugar transporter 0.0031 0.0271 0.1027
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0067 0.0649 0.0865
Plasmodium vivax threonine--tRNA ligase, putative 0.0013 0.0071 0.0068
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0104 0.133
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0136 0.1746
Echinococcus multilocularis synaptic vesicle 2 protein 0.0031 0.0271 0.0316
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0348 0.1365
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0013 0.0071 0.0261
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0044 0.0049
Schistosoma mansoni thyroid hormone receptor 0.001 0.0044 0.0056
Plasmodium vivax histidine--tRNA ligase, putative 0.0008 0.0017 0.0015
Trichomonas vaginalis helicase, putative 0.0006 0.0006 0.0014
Leishmania major glucose transporter/membrane transporter D2, putative 0.0069 0.0673 0.8771
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0067 0.0649 0.8677
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0663 0.0778
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0067 0.0649 0.0865
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0136 0.0511
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0185 0.2454
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0159
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0136 0.1791
Echinococcus multilocularis solute carrier family 22 0.0031 0.0271 0.0316
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0185 0.07
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0044 0.0159
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0044 0.0056
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.0673 0.8771
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0185 0.0724
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.001 0.004
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0013 0.0071 0.0892
Echinococcus multilocularis calcium dependent protein kinase 0.0064 0.0618 0.0725
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0663 0.0884
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.001 0.0099
Echinococcus granulosus FTZ F1 alpha 0.001 0.0044 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0014
Brugia malayi nuclear hormone receptor 0.001 0.0044 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0044 0.0159
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.001 0.003
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0013 0.0071 0.2114
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0069 0.0664 0.0661
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0104 0.0136
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0136 0.1746
Loa Loa (eye worm) hypothetical protein 0.0039 0.0348 0.1322
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0483 0.1841
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.005 0.0467 0.6074
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0339 0.4407
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0014
Trypanosoma brucei glucose transporter, putative 0.0069 0.0673 0.8771
Schistosoma mansoni glucose transporter 0.0031 0.0271 0.0359
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0136 0.0133
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0013 0.0071 0.0261
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.0208
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0112 0.0439
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.001 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0044 0.0159
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0044 0.0159
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0185 0.2454
Giardia lamblia Glycyl-tRNA synthetase 0.0013 0.0071 0.1055
Echinococcus multilocularis General substrate transporter 0.0192 0.1975 0.2321
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0185 0.3838
Onchocerca volvulus 0.0031 0.0271 0.106
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0104 0.0388
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0136 0.1746
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Brugia malayi beta-lactamase 0.0039 0.0348 0.1322
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0271 0.351
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.2217 0.8481
Trypanosoma brucei glucose transporter, putative 0.0069 0.0673 0.8771
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.256 1
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.4256 0.5006
Plasmodium vivax SET domain protein, putative 0.0031 0.027 0.0267
Echinococcus multilocularis GPCR, family 2 0.0016 0.0104 0.0119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.027 0.0358
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0104 0.0102
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0043 0.0054
Schistosoma mansoni glucose transport protein 0.0224 0.2308 0.3086
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.027 0.0315
Schistosoma mansoni hypothetical protein 0.0034 0.0297 0.0394
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.001 0.004
Trichomonas vaginalis myo-inositol transporter, putative 0.0031 0.0271 0.106
Plasmodium vivax glycine--tRNA ligase, putative 0.0013 0.0071 0.0068
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0008 0.0017 0.019
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0123 0.2348
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0348 0.1365
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0044 0.0159
Onchocerca volvulus 0.0031 0.0271 0.106
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0361 0.3768 0.5677
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0185 0.3838
Brugia malayi Pre-SET motif family protein 0.0031 0.027 0.1024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0185 0.2454
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.1027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0185 0.0724
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0028 0.0229 0.0868
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0044 0.0159
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0747 0.0997
Trypanosoma brucei glucose transporter, putative 0.0069 0.0673 0.8771
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0044 0.0159
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0185 0.2828
Echinococcus granulosus tumor protein p63 0.0333 0.3471 0.4643
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0593 0.079
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0044 0.0056
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Schistosoma mansoni protein kinase 0.0068 0.0663 0.0884
Onchocerca volvulus 0.0031 0.027 0.1058
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0008 0.0017 0.0019
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0044 0.0164
Echinococcus multilocularis lysyl tRNA synthetase 0.005 0.0467 0.0546
Onchocerca volvulus 0.0023 0.0185 0.0723
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0044 0.0049
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.004
Toxoplasma gondii sugar transporter ST3 0.0031 0.0271 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0673 0.265
Echinococcus multilocularis tumor protein p63 0.0333 0.3471 0.4082
Onchocerca volvulus 0.0031 0.0271 0.106
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0044 0.0159
Trypanosoma brucei glucose transporter, putative 0.0069 0.0673 0.8771
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0008 0.0017 0.0017
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0136 0.2756
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0044 0.0401 0.1577
Treponema pallidum prolyl-tRNA synthetase 0.0024 0.0189 1
Leishmania major histidyl-tRNA synthetase, putative 0.0008 0.0017 0.0195
Plasmodium vivax sugar transporter, putative 0.0031 0.0271 0.0268
Schistosoma mansoni cpg binding protein 0.003 0.0258 0.0342
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0068 0.0663 0.2531
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0044 0.0164
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0663 0.0884
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.001 0.0029
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0008 0.0017 0.0056
Loa Loa (eye worm) hypothetical protein 0.0252 0.2614 1
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0031 0.0271 0.1057
Trichomonas vaginalis set domain proteins, putative 0.0245 0.2531 1
Chlamydia trachomatis proline--tRNA ligase 0.0024 0.0189 0.3815
Brugia malayi steroid hormone receptor 0.001 0.0044 0.0159
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.0673 0.8771
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0136 0.0178
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.1027
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0185 0.3838
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0008 0.0017 0.019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0071 0.0261
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0348 0.1365
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0031 0.0271 0.5709
Echinococcus granulosus Sugar transporter ERD6 protein 0.0031 0.0271 0.0359
Mycobacterium tuberculosis Conserved protein 0.0039 0.0348 0.1359
Trypanosoma cruzi hexose transporter, putative 0.0069 0.0673 0.8771
Trypanosoma brucei glucose transporter 1E 0.0069 0.0673 0.8771
Mycobacterium tuberculosis Conserved hypothetical protein 0.0011 0.0055 0.0216
Leishmania major aspartyl-tRNA synthetase, putative 0.0008 0.0017 0.019
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0017 0.0019
Entamoeba histolytica protein kinase, putative 0.0068 0.0663 0.8875
Leishmania major hypothetical protein, conserved 0.0011 0.0055 0.0689
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0008 0.0017 0.0019
Schistosoma mansoni cpg binding protein 0.003 0.0258 0.0342
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0361 0.3768 0.3767
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0007 0.001 0.0117
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0008 0.0017 0.0153
Mycobacterium ulcerans beta-lactamase 0.0039 0.0348 0.7398
Brugia malayi hypothetical protein 0.0031 0.0271 0.1027
Onchocerca volvulus 0.001 0.0044 0.0164
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0185 0.07
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0104 0.012
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0008 0.0017 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0663 0.2613
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0104 0.0407
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0044 0.0159
Chlamydia trachomatis threonine--tRNA ligase 0.0013 0.0071 0.1193
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0008 0.0017 0.0059
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Schistosoma mansoni glucose transport protein 0.0224 0.2308 0.3086
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0348 0.1365
Trichomonas vaginalis esterase, putative 0.0039 0.0348 0.1365
Plasmodium vivax asparagine--tRNA ligase, putative 0.0008 0.0017 0.0015
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0104 0.0119
Onchocerca volvulus 0.0007 0.001 0.003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0185 0.07
Entamoeba histolytica hypothetical protein 0.0076 0.0747 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.0467 1
Brugia malayi major facilitator superfamily protein 0.0031 0.0271 0.1027
Trypanosoma cruzi sugar transporter, putative 0.0031 0.0271 0.351
Trypanosoma brucei glucose transporter, putative 0.0069 0.0673 0.8771
Plasmodium falciparum calcium-dependent protein kinase 3 0.0069 0.0664 0.0661
Plasmodium falciparum asparagine--tRNA ligase 0.0008 0.0017 0.0015
Schistosoma mansoni cpg binding protein 0.0029 0.0241 0.0319
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0044 0.0056
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Brugia malayi hypothetical protein 0.0076 0.0747 0.2852
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0185 0.3838
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.027 0.0315
Toxoplasma gondii propionate-CoA ligase 0.0007 0.001 0.0011
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0044 0.0056
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0006 0.0014
Mycobacterium ulcerans hypothetical protein 0.0023 0.0185 0.3838
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.1027
Onchocerca volvulus 0.0031 0.0271 0.106
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0008 0.0017 0.019
Chlamydia trachomatis lysine--tRNA ligase 0.005 0.0467 1
Brugia malayi beta-lactamase family protein 0.0039 0.0348 0.1322
Schistosoma mansoni hypothetical protein 0.0016 0.0104 0.0136
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.027 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.0208
Onchocerca volvulus 0.0007 0.001 0.003
Toxoplasma gondii protein kinase, putative 0.0632 0.6636 1
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0348 0.7398
Trichomonas vaginalis glucose transporter, putative 0.0069 0.0673 0.265
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0104 0.012
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0271 0.1027
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0044 0.0056
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0224 0.2308 0.3086
Brugia malayi hypothetical protein 0.0031 0.0271 0.1027
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0069 0.0673 0.265
Loa Loa (eye worm) hypothetical protein 0.0039 0.0348 0.1322
Plasmodium vivax hexose transporter 0.0224 0.2308 0.2306
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0006 0.0003 0.001
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0067 0.0649 0.0865
Plasmodium falciparum histidine--tRNA ligase, putative 0.0008 0.0017 0.0015
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0013 0.0071 0.1327
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0017 0.0019
Loa Loa (eye worm) histone methyltransferase 0.001 0.0043 0.0155
Entamoeba histolytica protein kinase, putative 0.0068 0.0663 0.8875
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0069 0.0664 0.0661
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0159
Loa Loa (eye worm) 63kd antigen 0.0008 0.0017 0.0056
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0185 0.3838
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0185 0.2828
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0271 0.106
Trichomonas vaginalis sugar transporter, putative 0.0069 0.0673 0.265
Brugia malayi Aspartyl-tRNA synthetase 0.0008 0.0017 0.0056
Loa Loa (eye worm) hypothetical protein 0.0068 0.0663 0.2531
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0068 0.0663 0.0884
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0112 0.0439
Toxoplasma gondii exonuclease III APE 0.0019 0.0136 0.0201
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0055 0.0689
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0006 0.0014
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0136 0.2064
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0044 0.0056
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0348 0.5343
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0025 0.003
Onchocerca volvulus 0.0031 0.0271 0.106
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0078 0.0766 1
Schistosoma mansoni hypothetical protein 0.0076 0.0747 0.0997
Brugia malayi AMP-binding enzyme family protein 0.0007 0.001 0.0029
Brugia malayi Sugar transporter family protein 0.0031 0.0271 0.1027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0044 0.0159
Schistosoma mansoni threonyl-tRNA synthetase 0.0008 0.0017 0.002
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0068 0.0663 0.865
Loa Loa (eye worm) hypothetical protein 0.0039 0.0348 0.1322
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0271 0.106
Trypanosoma brucei histidyl-tRNA synthetase 0.0008 0.0017 0.0195
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0104 0.133
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.1027
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0031 0.0271 0.0359
Onchocerca volvulus 0.0031 0.0271 0.106
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0069 0.0664 0.0661
Schistosoma mansoni glucose transport protein 0.0224 0.2308 0.3086
Schistosoma mansoni histidyl-tRNA synthetase 0.0008 0.0017 0.002
Brugia malayi beta-lactamase family protein 0.0039 0.0348 0.1322
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0159
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0013 0.0071 0.0892
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.0467 0.0621
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.027 0.0403
Schistosoma mansoni nuclear hormone receptor 0.001 0.0044 0.0056
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0224 0.2308 0.3086
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0008 0.0017 0.019
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0044 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0007 0.001 0.0029
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0663 0.0884
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0136 0.0527
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0104 0.133
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0008 0.0017 0.0195
Giardia lamblia Lysyl-tRNA synthetase 0.005 0.0467 0.7182
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0241 0.0912
Onchocerca volvulus 0.0039 0.0348 0.1365
Schistosoma mansoni survival motor neuron protein 0.0051 0.0483 0.0643
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.0014
Onchocerca volvulus 0.0245 0.2531 1
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0008 0.0017 0.0195
Brugia malayi hypothetical protein 0.0031 0.0271 0.1027
Loa Loa (eye worm) hypothetical protein 0.0007 0.001 0.0029
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0043 0.0048
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.1027
Onchocerca volvulus 0.0007 0.001 0.003
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0013 0.0071 0.0915
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0008 0.0017 0.019
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0017 0.0019
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0044 0.0056
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0008 0.0017 0.0017
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0013 0.0071 0.008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0025 0.003
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.001 0.001
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0455 0.0605
Onchocerca volvulus Putative transporter 0.0031 0.0271 0.106
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.001 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.046
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0348 0.4519
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.001 0.0011
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0104 0.0389
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0224 0.2308 0.3086
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0044 0.0164
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0055 0.0689
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0025 0.003
Echinococcus multilocularis microtubule associated protein 2 0.0711 0.7474 0.8793
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.0467 0.0621
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0271 0.106
Brugia malayi hypothetical protein 0.0252 0.2614 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0008 0.0017 0.019
Leishmania major aspartyl-tRNA synthetase, putative 0.0008 0.0017 0.019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0348 0.0462
Loa Loa (eye worm) hypothetical protein 0.0016 0.0104 0.0388
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0008 0.0017 0.019
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0104 0.0153
Trypanosoma cruzi glucose transporter, putative 0.0031 0.0271 0.351
Leishmania major glycyl tRNA synthetase, putative 0.0008 0.0017 0.0195
Schistosoma mansoni thyroid hormone receptor 0.001 0.0044 0.0056
Trypanosoma brucei glucose transporter, putative 0.0069 0.0673 0.8771
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0224 0.2308 0.2713
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0055 0.0689
Mycobacterium ulcerans lipase LipD 0.0039 0.0348 0.7398
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0044 0.0056
Brugia malayi major facilitator superfamily protein 0.0031 0.0271 0.1027
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.0673 0.8771
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0044 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0185 0.07
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Mycobacterium ulcerans integral membrane transport protein 0.0031 0.0271 0.5709
Giardia lamblia Prolyl-tRNA synthetase 0.0067 0.0649 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0013 0.0071 0.0276
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0067 0.0649 1
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.001 0.0099
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0224 0.2308 0.2713
Toxoplasma gondii glycyl-tRNA synthetase 0.0013 0.0071 0.0103
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0044 0.0056
Plasmodium falciparum hexose transporter 0.0224 0.2308 0.2306
Brugia malayi AMP-binding enzyme family protein 0.0007 0.001 0.0029
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0663 0.0778
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.1027
Onchocerca volvulus 0.0031 0.0271 0.106
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0104 0.0389
Schistosoma mansoni protein kinase 0.0068 0.0663 0.0884
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0013 0.0071 0.1055
Trypanosoma brucei glucose transporter 2A 0.0069 0.0673 0.8771
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0663 0.0884
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0271 0.106
Toxoplasma gondii sugar transporter ST1 0.0031 0.0271 0.0404
Onchocerca volvulus 0.0031 0.0271 0.106
Brugia malayi Pre-SET motif family protein 0.0215 0.2217 0.8481
Onchocerca volvulus 0.0039 0.0348 0.1365
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0078 0.0766 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Treponema pallidum glycyl-tRNA synthetase 0.0008 0.0017 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0224 0.2308 0.9119
Plasmodium vivax lysine--tRNA ligase, putative 0.005 0.0467 0.0464
Brugia malayi lysyl-tRNA synthetase 0.005 0.0467 0.1777
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.1027
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0297 0.1128
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0069 0.0664 0.0997
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0104 0.133
Giardia lamblia Hexose transporter 0.0031 0.0271 0.415
Onchocerca volvulus 0.0007 0.001 0.003
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0078 0.0766 0.1152
Brugia malayi nuclear receptor NHR-88 0.001 0.0044 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0055 0.0689
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0042 0.0387 0.1511
Echinococcus granulosus synaptic vesicle 2 protein 0.0031 0.0271 0.0359
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0104 0.0136
Echinococcus granulosus histidyl tRNA synthetase 0.0008 0.0017 0.002
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Giardia lamblia Asparaginyl-tRNA synthetase 0.0008 0.0017 0.0225
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0013 0.0071 0.1327
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0104 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0271 0.106
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.0387 0.5947
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0078 0.0766 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.001 0.0099
Brugia malayi AMP-binding enzyme family protein 0.0007 0.001 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.027 0.1024
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.001 0.0099
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0348 0.1359
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0008 0.0017 0.019
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0136 0.6929
Plasmodium falciparum glycine--tRNA ligase 0.0008 0.0017 0.0015
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0031 0.0271 0.0316
Onchocerca volvulus 0.0031 0.0271 0.106
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0159
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0044 0.0056
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0008 0.0017 0.0019
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Brugia malayi Cam kinase protein 1 0.0068 0.0663 0.2531
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.046
Loa Loa (eye worm) hypothetical protein 0.0039 0.0348 0.1322
Mycobacterium ulcerans hypothetical protein 0.0011 0.0055 0.0987
Loa Loa (eye worm) hypothetical protein 0.0023 0.0185 0.07
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0013 0.0071 0.0915
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0008 0.0017 0.019
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.0271 0.0404
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0185 0.2392
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0044 0.0049
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.004
Toxoplasma gondii lysine-tRNA ligase 0.005 0.0467 0.0699
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0104 0.0388
Echinococcus granulosus survival motor neuron protein 1 0.0252 0.2614 0.3495
Trichomonas vaginalis glucose transporter, putative 0.0069 0.0673 0.265
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0013 0.0071 0.027
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0348 0.4519
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0013 0.0071 0.0261
Leishmania major glucose transporter, lmgt2 0.0069 0.0673 0.8771
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0031 0.0271 0.5709
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0044 0.0159
Plasmodium falciparum threonine--tRNA ligase 0.0013 0.0071 0.0068
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0055 0.0689
Mycobacterium ulcerans hypothetical protein 0.0039 0.0348 0.7398
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0348 0.0406
Mycobacterium ulcerans sugar transporter 0.0031 0.0271 0.5709
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.005 0.0467 0.6074
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0271 0.106
Entamoeba histolytica hypothetical protein 0.0076 0.0747 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.1027
Plasmodium falciparum lysine--tRNA ligase 0.005 0.0467 0.0464
Schistosoma mansoni hypothetical protein 0.0407 0.4256 0.5693
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.001 0.0029
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.85 1
Echinococcus multilocularis geminin 0.0169 0.1727 0.2029
Plasmodium falciparum proline--tRNA ligase 0.0078 0.0766 0.0764
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0104 0.0136
Schistosoma mansoni hypothetical protein 0.0169 0.1727 0.2307
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0348 0.1359
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0271 0.1027
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.1027
Toxoplasma gondii facilitative glucose transporter GT1 0.0224 0.2308 0.3476
Loa Loa (eye worm) beta-lactamase 0.0039 0.0348 0.1322
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.0014
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.001 0.0099
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0031 0.0271 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0067 0.0649 0.076
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0008 0.0017 0.0057
Schistosoma mansoni glycyl-tRNA synthetase 0.0013 0.0071 0.0091
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0044 0.0049
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Entamoeba histolytica hypothetical protein 0.0076 0.0747 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.001 0.0099
Schistosoma mansoni hypothetical protein 0.0016 0.0104 0.0136
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0068 0.0663 0.2531
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0017 0.0019
Leishmania major lysyl-tRNA synthetase, putative 0.0008 0.0017 0.019
Plasmodium vivax aspartate--tRNA ligase, putative 0.0008 0.0017 0.0015
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0464 0.1766
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0136 0.0511
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0013 0.0071 0.0103
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0067 0.0649 0.2474
Schistosoma mansoni sugar transporter 0.0031 0.0271 0.0359
Mycobacterium leprae Probable lipase LipE 0.0039 0.0348 0.5343
Leishmania major glucose transporter, lmgt1 0.0069 0.0673 0.8771
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.001 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0044 0.0159
Echinococcus granulosus glycyl tRNA synthetase 0.0013 0.0071 0.0091
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0136 0.0133
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0104 0.012
Leishmania major lysyl-tRNA synthetase, putative 0.005 0.0467 0.6074
Onchocerca volvulus 0.0031 0.0271 0.106
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.001 0.004
Plasmodium vivax calcium-dependent protein kinase, putative 0.0069 0.0664 0.0661
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0013 0.0071 0.0892
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0348 0.1322
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0055 0.0208
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0123 0.012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0044 0.0159
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0136 0.4685
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0069 0.0664 0.0997
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0007 0.001 0.0117
Treponema pallidum threonyl-tRNA synthetase 0.0013 0.0071 0.3127
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0008 0.0017 0.0022
Plasmodium falciparum protein kinase 7 0.0632 0.6636 0.6635
Schistosoma mansoni hypothetical protein 0.0169 0.1727 0.2307
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.1027
Brugia malayi glycyl-tRNA synthetase 0.0013 0.0071 0.0261
Plasmodium vivax asparagine--tRNA ligase, putative 0.0008 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.1027
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0008 0.0017 0.0057
Toxoplasma gondii aspartate-tRNA ligase 0.0008 0.0017 0.0022
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0008 0.0017 0.0195
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Echinococcus granulosus solute carrier family 22 0.0031 0.0271 0.0359
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0348 0.0345
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0008 0.0017 0.0056
Onchocerca volvulus 0.0031 0.0271 0.106
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0136 0.0157
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.1027
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0078 0.0766 1
Entamoeba histolytica hypothetical protein 0.005 0.0467 0.6232
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0663 0.0778
Echinococcus multilocularis solute carrier family 22 0.0031 0.0271 0.0316
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.1027
Plasmodium falciparum aspartate--tRNA ligase 0.0008 0.0017 0.0015
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0044 0.0049
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0159
Plasmodium falciparum calcium-dependent protein kinase 2 0.0069 0.0664 0.0661
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Trypanosoma cruzi hexose transporter 0.0069 0.0673 0.8771
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.1027
Loa Loa (eye worm) sugar transporter 0.0224 0.2308 0.8831
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.046
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0271 0.1027
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0524 0.0786
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0271 0.106
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0224 0.2308 0.2713
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.046
Loa Loa (eye worm) hypothetical protein 0.0031 0.0271 0.1027
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0104 0.0136
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0663 0.0778
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0044 0.0056
Entamoeba histolytica hypothetical protein 0.0076 0.0747 1
Schistosoma mansoni hypothetical protein 0.0224 0.2308 0.3086
Leishmania major glucose transporter, lmgt3 0.0069 0.0673 0.8771
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0159
Toxoplasma gondii anticodon binding domain-containing protein 0.0008 0.0017 0.0022
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0008 0.0017 0.0195
Plasmodium falciparum asparagine--tRNA ligase 0.0008 0.0017 0.0015
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0007 0.001 0.0117
Trypanosoma brucei glucose transporter, putative 0.0069 0.0673 0.8771
Brugia malayi CXXC zinc finger family protein 0.0029 0.0241 0.0912

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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