Detailed information for compound 74667

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 619.814 | Formula: C28H53N5O8S
  • H donors: 7 H acceptors: 7 LogP: 2.63 Rotable bonds: 24
    Rule of 5 violations (Lipinski): 3
  • SMILES: CSCC[C@@H](C(=O)NC([C@H](CC(=O)N[C@@H](C(=O)NO)C(C)C)O)CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)OC(C)(C)C
  • InChi: 1S/C28H53N5O8S/c1-15(2)13-19(20(34)14-21(35)31-23(17(5)6)26(38)33-40)30-24(36)18(11-12-42-10)29-25(37)22(16(3)4)32-27(39)41-28(7,8)9/h15-20,22-23,34,40H,11-14H2,1-10H3,(H,29,37)(H,30,36)(H,31,35)(H,32,39)(H,33,38)/t18-,19?,20-,22-,23+/m0/s1
  • InChiKey: WMMQCGDAZPJOPB-FMMALVMXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Sgs1 DNA helicase, putative 0.004 0.0068 0.5186
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0163 0.0596
Echinococcus multilocularis Regulator of G protein signaling 20 0.0041 0.007 0.007
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0019 0.0002 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0064 0.0235
Loa Loa (eye worm) hypothetical protein 0.0709 0.213 0.7766
Onchocerca volvulus Poor gastrulation protein homolog 0.0024 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0027 0.0027 0.0097
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0019 0.0002 0.0007
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0011 0.0039
Loa Loa (eye worm) hypothetical protein 0.0039 0.0064 0.0235
Echinococcus granulosus lamin dm0 0.0115 0.0298 0.0298
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0036 0.0055 0.088
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0033 0.1195
Schistosoma mansoni DNA helicase recq5 0.004 0.0068 0.0156
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0089 0.0324
Schistosoma mansoni polycystin 1-related 0.0022 0.0011 0.0025
Echinococcus granulosus neutral amino acid transporter A 0.0247 0.0706 0.0706
Brugia malayi Sulfatase family protein 0.0019 0.0002 0.0008
Onchocerca volvulus 0.0443 0.1308 0.4179
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0061 0.013 0.3672
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0042 0.0152
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0061 0.013 0.3672
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0033 0.0531
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Schistosoma mansoni axis inhibition protein axin 0.0041 0.007 0.0163
Schistosoma mansoni loxhd1 0.0022 0.0011 0.0025
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.007 0.0257
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0064 0.0149
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0061 0.0131 0.2083
Schistosoma mansoni thyroid hormone receptor 0.0326 0.0948 0.2188
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0064 0.0064
Onchocerca volvulus 0.0019 0 0.0001
Brugia malayi Excitatory amino acid transporter 0.0247 0.0706 0.2573
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0053 0.0108 0.0393
Schistosoma mansoni blooms syndrome DNA helicase 0.0046 0.0085 0.0195
Schistosoma mansoni regulator of G protein signaling 0.0041 0.007 0.0163
Brugia malayi 6-phosphofructokinase 0.0222 0.0627 0.2286
Schistosoma mansoni survival motor neuron protein 0.005 0.0098 0.0226
Loa Loa (eye worm) hypothetical protein 0.0113 0.0291 0.1062
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0163 0.0163
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0128 0.0408
Brugia malayi Cytochrome P450 family protein 0.0076 0.0177 0.0647
Schistosoma mansoni z-protein (S1r protein) 0.0041 0.007 0.0163
Brugia malayi Nuclear hormone receptor E75 0.0019 0 0.0001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0115 0.0298 0.1086
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.014 0.2227
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0037 0.0058 0.0211
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0039
Brugia malayi conserved hypotetical protein 0.0019 0 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Onchocerca volvulus 0.1033 0.3129 1
Schistosoma mansoni coup transcription factor 0.0039 0.0064 0.0149
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0041 0.007 0.0163
Leishmania major cathepsin L-like protease 0.0064 0.014 0.1806
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1484 0.4517 0.4517
Echinococcus granulosus axis inhibition protein axin 0.0041 0.007 0.007
Echinococcus granulosus RUN 0.0022 0.0011 0.0011
Brugia malayi Pre-SET motif family protein 0.0131 0.0346 0.1263
Echinococcus multilocularis neutral amino acid transporter A 0.0247 0.0706 0.0706
Brugia malayi Glutamate receptor 1 precursor 0.0057 0.0118 0.0429
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0144 0.0388 0.0388
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0128 0.6219
Schistosoma mansoni nuclear receptor 0.0019 0 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0072 0.0072
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0062 0.0062
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0033 0.0531
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0287 0.0826 0.0826
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.007 0.0225
Brugia malayi Guanylyl cyclase protein 23 0.0027 0.0027 0.0097
Schistosoma mansoni regulator of G protein signaling 0.0041 0.007 0.0163
Brugia malayi hypothetical protein 0.0022 0.0011 0.0039
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0046 0.0084 0.1346
Loa Loa (eye worm) RGC/RGC protein kinase 0.0027 0.0027 0.0097
Echinococcus granulosus neutral amino acid transporter A 0.0247 0.0706 0.0706
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.007 0.0163
Loa Loa (eye worm) hypothetical protein 0.0061 0.013 0.0474
Brugia malayi Metabotropic glutamate receptor precursor. 0.0161 0.0441 0.1607
Schistosoma mansoni hypothetical protein 0.0456 0.1349 0.3114
Loa Loa (eye worm) hypothetical protein 0.0039 0.0064 0.0235
Echinococcus granulosus glutamate receptor subunit protein glur 0.0026 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0443 0.1308 0.4768
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0275 0.3547
Echinococcus granulosus pikachurin 0.0048 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.007 0.0225
Echinococcus multilocularis neutral amino acid transporter A 0.0247 0.0706 0.0706
Schistosoma mansoni glutamate receptor NMDA 0.0057 0.0118 0.0272
Loa Loa (eye worm) hypothetical protein 0.0061 0.013 0.0474
Entamoeba histolytica phosphofructokinase, putative 0.0222 0.0627 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0041 0.007 0.0257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0064 0.0235
Loa Loa (eye worm) hypothetical protein 0.0061 0.013 0.0474
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0064 0.0149
Mycobacterium tuberculosis Possible hydrolase 0.0019 0.0002 0.0007
Trichomonas vaginalis rotamase, putative 0.0037 0.0058 0.0185
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0057 0.0118 0.0118
Echinococcus multilocularis glutamate receptor 2 0.0058 0.0122 0.0122
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0064 0.0149
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0041 0.007 0.1934
Schistosoma mansoni hypothetical protein 0.0024 0.0017 0.004
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1423 0.433 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0222 0.0627 1
Brugia malayi PXA domain containing protein 0.0041 0.007 0.0257
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0061 0.0131 0.2083
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0062 0.0985
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0051 0.0101 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.007 0.0225
Schistosoma mansoni protein kinase 0.0027 0.0027 0.0061
Leishmania major cathepsin L-like protease 0.0064 0.014 0.1806
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0089 0.0089
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0007 0.0105
Brugia malayi hypothetical protein 0.0019 0 0.0001
Echinococcus granulosus receptor type guanylyl cyclase 0.0027 0.0027 0.0027
Echinococcus multilocularis leukotriene A 4 hydrolase 0.012 0.0313 0.0313
Schistosoma mansoni serine-rich repeat protein 0.0766 0.2305 0.5324
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0068 0.0876
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0039 0.0064 0.0235
Leishmania major hypothetical protein, conserved 0.0025 0.0019 0.0246
Mycobacterium tuberculosis Probable sulfatase 0.0019 0.0002 0.0007
Onchocerca volvulus 0.0039 0.0064 0.0206
Mycobacterium ulcerans arylsulfatase AtsD 0.0019 0.0002 0.0007
Echinococcus multilocularis excitatory amino acid transporter 2 0.0247 0.0706 0.0706
Loa Loa (eye worm) hypothetical protein 0.0115 0.0298 0.1086
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0247 0.0706 0.9123
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.011 0.0281 0.0281
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0064 0.0064
Brugia malayi hypothetical protein 0.0041 0.007 0.0257
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0064 0.0064
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0064 0.0206
Mycobacterium tuberculosis Probable reductase 0.0108 0.0275 0.3547
Echinococcus multilocularis slit 2 protein 0.0048 0.0091 0.0091
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0056 0.0114 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Onchocerca volvulus 0.0027 0.0027 0.0085
Trypanosoma brucei trypanothione reductase 0.0047 0.0089 0.1416
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0061 0.0131 0.0131
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.004 0.0068 0.3025
Schistosoma mansoni lamin 0.0115 0.0298 0.0687
Schistosoma mansoni nuclear hormone receptor 0.0019 0 0.0001
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0 0.0001
Echinococcus granulosus dnaJ subfamily B 0.0456 0.1349 0.1349
Loa Loa (eye worm) phosphofructokinase 0.0222 0.0627 0.2286
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.0702 0.0702
Plasmodium vivax thrombospondin-related anonymous protein 0.0061 0.013 0.3672
Echinococcus granulosus glutamate NMDA receptor subunit 0.0057 0.0118 0.0118
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0246 0.0702 0.256
Onchocerca volvulus 0.0061 0.013 0.0415
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.006 0.0128 0.9787
Echinococcus granulosus expressed protein 0.0805 0.2423 0.2423
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0222 0.0627 0.106
Echinococcus multilocularis lamin dm0 0.0115 0.0298 0.0298
Plasmodium falciparum cysteine repeat modular protein 1 0.0025 0.0019 0.0434
Brugia malayi regulator of G-protein signaling egl-10 0.0041 0.007 0.0257
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0275 0.3547
Plasmodium falciparum thrombospondin-related anonymous protein 0.0061 0.013 0.6329
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0019 0.0002 0.0007
Schistosoma mansoni metabotropic glutamate receptor 0.0137 0.0367 0.0846
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0061 0.013 0.6329
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0134 0.0357 0.1303
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0061 0.0131 0.0476
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0083 0.0199 0.3059
Echinococcus multilocularis Protein lozenge 0.0056 0.0114 0.0114
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0222 0.0627 1
Schistosoma mansoni aldehyde dehydrogenase 0.0269 0.0773 0.1785
Brugia malayi nuclear receptor RXR 0.0021 0.0007 0.0026
Treponema pallidum ATP-dependent DNA helicase 0.0021 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0027 0.0027 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.014 0.2227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.014 0.2227
Schistosoma mansoni lamin 0.0115 0.0298 0.0687
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0064 0.0235
Schistosoma mansoni glutamate receptor NMDA 0.0084 0.0201 0.0465
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0007 0.0026
Schistosoma mansoni metabotropic glutamate receptor 0.0085 0.0206 0.0477
Toxoplasma gondii exonuclease III APE 0.0061 0.0131 0.1689
Brugia malayi CXXC zinc finger family protein 0.0032 0.0042 0.0152
Onchocerca volvulus 0.0061 0.013 0.0415
Echinococcus granulosus geminin 0.0189 0.0525 0.0525
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0062 0.0197
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0007 0.0017
Loa Loa (eye worm) 6-phosphofructokinase 0.0222 0.0627 0.2286
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0275 0.4299
Schistosoma mansoni rab6-interacting 0.0022 0.0011 0.0025
Echinococcus multilocularis GPCR, family 3, C terminal 0.0024 0.0017 0.0017
Brugia malayi von Willebrand factor type A domain containing protein 0.0061 0.013 0.0474
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0144 0.0388 0.0388
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0061 0.0131 0.167
Brugia malayi Doublecortin family protein 0.0022 0.0011 0.0039
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0033 0.0531
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Mycobacterium ulcerans hydrolase 0.0019 0.0002 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0346 0.08
Loa Loa (eye worm) hypothetical protein 0.0039 0.0064 0.0235
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0144 0.0388 0.0388
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0064 0.0206
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0086 0.0209 0.0209
Treponema pallidum glutamate transporter 0.011 0.0281 0.0474
Brugia malayi cytoplasmic intermediate filament protein 0.0062 0.0133 0.0485
Loa Loa (eye worm) glutamate receptor 1 0.0057 0.0118 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.007 0.0225
Schistosoma mansoni intermediate filament proteins 0.0115 0.0298 0.0687
Loa Loa (eye worm) hypothetical protein 0.0061 0.013 0.0474
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0247 0.0706 0.2255
Echinococcus multilocularis bloom syndrome protein 0.0067 0.0148 0.0148
Echinococcus granulosus GPCR family 3 C terminal 0.0024 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0008
Entamoeba histolytica hypothetical protein 0.0061 0.013 0.2072
Toxoplasma gondii aldehyde dehydrogenase 0.0269 0.0773 1
Brugia malayi Nuclear hormone receptor E75 0.0019 0 0.0001
Echinococcus granulosus excitatory amino acid transporter 3 0.0247 0.0706 0.0706
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.0627 0.2003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0064 0.0149
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0275 0.3547
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.007 0.0163
Loa Loa (eye worm) hypothetical protein 0.0027 0.0027 0.0097
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0222 0.0627 1
Echinococcus multilocularis 6 phosphofructokinase 0.0222 0.0627 0.0627
Brugia malayi Pre-SET motif family protein 0.0908 0.2742 1
Brugia malayi Cache domain containing protein 0.0657 0.1968 0.7177
Mycobacterium ulcerans aldehyde dehydrogenase 0.0269 0.0773 1
Schistosoma mansoni hypothetical protein 0.0189 0.0525 0.1213
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0048 0.0091 0.0211
Echinococcus granulosus leukotriene A 4 hydrolase 0.012 0.0313 0.0313
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0128 0.6219
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0346 0.08
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0064 0.0235
Loa Loa (eye worm) hypothetical protein 0.0025 0.0019 0.0069
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0062 0.0133 0.0485
Trichomonas vaginalis DNA helicase recq1, putative 0.0067 0.0148 0.0473
Mycobacterium ulcerans aldehyde dehydrogenase 0.0269 0.0773 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0061 0.013 0.0474
Onchocerca volvulus 0.0019 0 0.0001
Echinococcus multilocularis glutamate receptor 2 0.0084 0.0201 0.0201
Echinococcus granulosus beta-adrenergic receptor kinase 0.0041 0.007 0.007
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0131 0.3693
Loa Loa (eye worm) excitatory amino acid transporter 0.0247 0.0706 0.2573
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0118 0.0272
Loa Loa (eye worm) hypothetical protein 0.0039 0.0064 0.0235
Echinococcus multilocularis cpg binding protein 0.0034 0.0047 0.0047
Brugia malayi laminin alpha chain 0.0048 0.0091 0.0333
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0007 0.0085
Echinococcus multilocularis voltage dependent calcium channel subunit 0.3263 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0064 0.0235
Echinococcus granulosus axis inhibition protein axin 0.0041 0.007 0.007
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.0702 0.0702
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0 0.0001
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0089 0.1416
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0027 0.0027 0.0085
Echinococcus granulosus glutamate receptor 2 0.0084 0.0201 0.0201
Onchocerca volvulus 0.0115 0.0298 0.0952
Schistosoma mansoni hypothetical protein 0.005 0.0098 0.0226
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0007 0.0007
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.014 0.2227
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0098 0.0357
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0 0.0001
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0061 0.013 0.013
Onchocerca volvulus 0.0061 0.013 0.0415
Loa Loa (eye worm) DR-78 0.0019 0 0.0001
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0144 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0061 0.013 0.0474
Loa Loa (eye worm) hypothetical protein 0.0038 0.0062 0.0225
Loa Loa (eye worm) hypothetical protein 0.0443 0.1308 0.4768
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0041 0.007 0.007
Mycobacterium ulcerans hypothetical protein 0.0022 0.001 0.0112
Onchocerca volvulus 0.0061 0.013 0.0415
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0062 0.0133 0.0133
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0083 0.0199 0.0725
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0008
Loa Loa (eye worm) PXA domain-containing protein 0.0041 0.007 0.0257
Onchocerca volvulus 0.0131 0.0346 0.1107
Brugia malayi Protein kinase domain containing protein 0.0025 0.0019 0.0069
Echinococcus granulosus bloom syndrome protein 0.0067 0.0148 0.0148
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0064 0.0064
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0027 0.0027 0.0027
Echinococcus granulosus tumor protein p63 0.0392 0.1152 0.1152
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0033 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Loa Loa (eye worm) CUTiclin-Like family member 0.0061 0.013 0.0474
Echinococcus granulosus ATP dependent DNA helicase Q1 0.004 0.0068 0.0068
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0908 0.2742 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.014 0.2227
Brugia malayi ecdysone receptor 0.0019 0 0.0001
Brugia malayi von Willebrand factor type A domain containing protein 0.0061 0.013 0.0474
Brugia malayi nuclear hormone receptor 0.0039 0.0064 0.0235
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0039
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0064 0.0149
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0064 0.0206
Leishmania major cathepsin L-like protease 0.0064 0.014 0.1806
Brugia malayi Immunoglobulin I-set domain containing protein 0.0061 0.013 0.0474
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0064 0.0149
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0163 0.2607
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0027 0.0027 0.0097
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0064 0.0235
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0064 0.0235
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0064 0.0235
Brugia malayi hypothetical protein 0.0021 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0064 0.0235
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0061 0.013 0.6329
Loa Loa (eye worm) hypothetical protein 0.0061 0.013 0.0474
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0011 0.0194
Echinococcus multilocularis neurogenic locus notch protein 0.0048 0.0091 0.0091
Loa Loa (eye worm) RGC/RGC protein kinase 0.0027 0.0027 0.0097
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.012 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0128 0.3611
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0091 0.0333
Onchocerca volvulus 0.005 0.0098 0.0313
Entamoeba histolytica recQ family helicase, putative 0.0046 0.0084 0.1346
Echinococcus multilocularis thyroid hormone receptor alpha 0.0326 0.0948 0.0948
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0269 0.0773 0.0773
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0064 0.0064
Toxoplasma gondii 6-phosphofructokinase 0.006 0.0128 0.1653
Entamoeba histolytica hypothetical protein 0.0041 0.007 0.1124
Onchocerca volvulus 0.0032 0.0042 0.0133
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0145 0.1873
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.007 0.007
Plasmodium vivax SET domain protein, putative 0.0131 0.0346 1
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Leishmania major ATP-dependent phosphofructokinase 0.0222 0.0627 0.8106
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0144 0.0388 0.0388
Schistosoma mansoni 6-phosphofructokinase 0.0222 0.0627 0.1447
Echinococcus granulosus neutral amino acid transporter 0.0247 0.0706 0.0706
Loa Loa (eye worm) hypothetical protein 0.0048 0.0091 0.0333
Brugia malayi nuclear receptor NHR-88 0.0019 0 0.0001
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0062 0.0985
Mycobacterium ulcerans arylsulfatase AtsB 0.0019 0.0002 0.0007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0064 0.0064
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0062 0.0225
Loa Loa (eye worm) hypothetical protein 0.0051 0.0101 0.0367
Loa Loa (eye worm) hypothetical protein 0.0024 0.0017 0.0063
Loa Loa (eye worm) hypothetical protein 0.0048 0.0091 0.0333
Loa Loa (eye worm) hypothetical protein 0.0029 0.0033 0.0121
Loa Loa (eye worm) hypothetical protein 0.0027 0.0027 0.0097
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0056 0.0114 0.0114
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0247 0.0706 0.0706
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1932 0.5899 1
Schistosoma mansoni cpg binding protein 0.0034 0.0047 0.0109
Brugia malayi hypothetical protein 0.0246 0.0702 0.256
Brugia malayi A-kinase anchor protein 10, precursor 0.0041 0.007 0.0257
Echinococcus granulosus nmda type glutamate receptor 0.0045 0.0081 0.0081
Brugia malayi exodeoxyribonuclease III family protein 0.0061 0.0131 0.0476
Loa Loa (eye worm) hypothetical protein 0.0061 0.013 0.0474
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.014 0.2227
Echinococcus multilocularis NMDA receptor 0.0086 0.0209 0.0209
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0118 0.0272
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.014 0.2227
Schistosoma mansoni hypothetical protein 0.0766 0.2305 0.5324
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0046 0.0084 0.1346
Schistosoma mansoni hypothetical protein 0.0026 0.0022 0.0051
Loa Loa (eye worm) hypothetical protein 0.0061 0.013 0.0474
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0064 0.0235
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.0084 0.027
Echinococcus granulosus atrial natriuretic peptide receptor 0.0027 0.0027 0.0027
Schistosoma mansoni tyrosine kinase 0.0027 0.0027 0.0061
Schistosoma mansoni zinc finger protein 0.0019 0 0.0001
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0061 0.013 0.0474
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0269 0.0773 1
Mycobacterium ulcerans arylsulfatase, AslA 0.0019 0.0002 0.0007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0064 0.0149
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0717 0.2155 0.4976
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.007 0.0163
Brugia malayi hypothetical protein 0.0022 0.0011 0.0039
Echinococcus granulosus collagen alpha 1VII chain 0.0061 0.013 0.013
Echinococcus multilocularis regulator of G protein signaling 0.0041 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0657 0.1968 0.7177
Loa Loa (eye worm) glutamate receptor 0.0161 0.0441 0.1607
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0128 0.0408
Loa Loa (eye worm) runx1 0.0056 0.0114 0.0417
Loa Loa (eye worm) hypothetical protein 0.0061 0.013 0.0474
Schistosoma mansoni rotamase 0.0037 0.0058 0.0134
Brugia malayi hypothetical protein 0.0061 0.013 0.0474
Mycobacterium ulcerans epimerase 0.0022 0.001 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0064 0.0235
Echinococcus granulosus metabotropic glutamate receptor 5 0.0196 0.0546 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0131 0.0346 0.0346
Schistosoma mansoni ap endonuclease 0.0061 0.0131 0.0301
Schistosoma mansoni nuclear receptor 0.0019 0 0.0001
Echinococcus granulosus Regulator of G protein signaling 20 0.0041 0.007 0.007
Echinococcus granulosus lamin 0.0115 0.0298 0.0298
Entamoeba histolytica hypothetical protein 0.0027 0.0027 0.0424
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0011 0.0011
Brugia malayi 6-phosphofructokinase 0.0222 0.0627 0.2286
Echinococcus granulosus excitatory amino acid transporter 2 0.0247 0.0706 0.0706
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.0257
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0312 0.4028
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0064 0.0064
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.007 0.007
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0011 0.0011
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0 0.0001
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0061 0.0131 0.1689
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0131 0.0417
Brugia malayi hypothetical protein 0.0443 0.1308 0.4768
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.0257
Leishmania major extracellular receptor, putative 0.0027 0.0027 0.0344
Loa Loa (eye worm) hypothetical protein 0.0047 0.0087 0.0317
Mycobacterium ulcerans aldehyde dehydrogenase 0.0269 0.0773 1
Brugia malayi von Willebrand Factor 0.0061 0.013 0.0474
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0041 0.007 0.0257
Brugia malayi steroid hormone receptor 0.0039 0.0064 0.0235
Schistosoma mansoni glutamate receptor kainate 0.0117 0.0305 0.0703
Loa Loa (eye worm) intermediate filament protein 0.0115 0.0298 0.1086
Schistosoma mansoni nuclear hormone receptor 0.0019 0 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0131 0.0417
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0247 0.0706 0.0706
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0062 0.4729
Onchocerca volvulus 0.0115 0.0298 0.0952
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Brugia malayi tailless protein 0.0019 0 0.0001
Brugia malayi hypothetical protein 0.0041 0.007 0.0257
Loa Loa (eye worm) hypothetical protein 0.0057 0.012 0.0438
Loa Loa (eye worm) hypothetical protein 0.0027 0.0027 0.0097
Echinococcus granulosus Excitatory amino acid transporter 0.0247 0.0706 0.0706
Loa Loa (eye worm) RecQ helicase 0.0067 0.0148 0.054
Brugia malayi von Willebrand factor type A domain containing protein 0.0061 0.013 0.0474
Brugia malayi hypothetical protein 0.0029 0.0033 0.0121
Treponema pallidum hypothetical protein 0.0061 0.013 0.0217
Onchocerca volvulus 0.0022 0.0011 0.0035
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0064 0.0064
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.014 0.2227
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0098 0.1556
Schistosoma mansoni ATP-binding cassette transporter 0.0057 0.0118 0.0272
Schistosoma mansoni lipoxygenase 0.0022 0.0011 0.0025
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0061 0.013 0.0474
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.004 0.0068 0.0068
Brugia malayi hypothetical protein 0.0042 0.0072 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0064 0.0235
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0089 0.1128
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Schistosoma mansoni regulator of G protein signaling 0.0041 0.007 0.0163
Trichomonas vaginalis 6-phosphofructokinase, putative 0.006 0.0128 0.0408
Echinococcus multilocularis glutamate receptor 2 0.0057 0.0118 0.0118
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0312 0.4028
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0904 0.2729 0.2729
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0022 0.001 0.0038
Schistosoma mansoni regulator of G protein signaling 0.0041 0.007 0.0163
Loa Loa (eye worm) RGC/RGC protein kinase 0.0027 0.0027 0.0097
Echinococcus multilocularis lamin 0.0115 0.0298 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0061 0.013 0.0474
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0026
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0064 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0064 0.0064
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0064 0.0149
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0055 0.088
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0163 0.0377
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0169 0.0463 0.1069
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0163 0.2113
Loa Loa (eye worm) RGS-3 protein 0.0041 0.007 0.0257
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0062 0.0197
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0312 0.4901
Brugia malayi hypothetical protein 0.0019 0.0002 0.0008
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0061 0.0131 0.6417
Brugia malayi hypothetical protein 0.0027 0.0027 0.0097
Brugia malayi follicle stimulating hormone receptor 0.048 0.1424 0.5191
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0062 0.0062
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0269 0.0773 1
Brugia malayi nuclear hormone receptor 0.0019 0 0.0001
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0123 0.1955
Mycobacterium ulcerans arylsulfatase AtsD 0.0019 0.0002 0.0007
Brugia malayi ecdysteroid receptor 0.0039 0.0064 0.0235
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0061 0.013 0.0474
Echinococcus multilocularis expressed protein 0.0037 0.0058 0.0058
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0011 0.0011
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0086 0.0209 0.0209
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0007 0.0017
Echinococcus multilocularis musashi 0.0115 0.0298 0.0298
Echinococcus granulosus glutamate receptor 2 0.0058 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0061 0.013 0.0474
Echinococcus multilocularis nmda type glutamate receptor 0.0027 0.0027 0.0027
Brugia malayi laminin-like protein K08C7.3 precursor 0.0048 0.0091 0.0333
Brugia malayi Zona pellucida-like domain containing protein 0.0061 0.013 0.0474
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0199 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0064 0.0235
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0128 0.0408
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0064 0.0149
Loa Loa (eye worm) hypothetical protein 0.0039 0.0064 0.0235
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0086 0.0209 0.0209
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0128 0.1791
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0137 0.0367 0.0367
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0089 0.2471
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0061 0.0131 0.167
Schistosoma mansoni hypothetical protein 0.0042 0.0072 0.0166
Schistosoma mansoni thyroid hormone receptor 0.0326 0.0948 0.2188
Schistosoma mansoni hypothetical protein 0.0022 0.0011 0.0025
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.0257
Echinococcus multilocularis sodium:dicarboxylate symporter 0.011 0.0281 0.0281
Entamoeba histolytica recQ family DNA helicase 0.0021 0.0007 0.0105
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.001 0.0112
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.011 0.0281 0.0649
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0062 0.0799
Brugia malayi von Willebrand factor type A domain containing protein 0.0061 0.013 0.0474
Brugia malayi Receptor family ligand binding region containing protein 0.0027 0.0027 0.0097
Toxoplasma gondii phosphofructokinase PFKII 0.006 0.0128 0.1653
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0163 0.0163
Echinococcus multilocularis nmda type glutamate receptor 0.0045 0.0081 0.0081
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0061 0.0131 0.0131
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0011 0.0011
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0033 0.1195
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0072 0.0072
Schistosoma mansoni 6-phosphofructokinase 0.0222 0.0627 0.1447
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Schistosoma mansoni cell polarity protein 0.0048 0.0091 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0033 0.0851
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0061 0.0131 0.2083
Loa Loa (eye worm) abnormal epIthelia family member 0.0048 0.0091 0.0333
Schistosoma mansoni slit 0.0048 0.0091 0.0211
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0007 0.0026
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0026 0.0022 0.0022
Echinococcus granulosus tyrosine kinase 0.0027 0.0027 0.0027
Brugia malayi Glutamate receptor 2 precursor 0.0057 0.0118 0.0429
Toxoplasma gondii peptidylprolyl isomerase 0.0036 0.0055 0.0713
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0062 0.0062
Treponema pallidum glutamate/aspartate transporter 0.011 0.0281 0.0474
Brugia malayi von Willebrand factor type A domain containing protein 0.0061 0.013 0.0474
Brugia malayi Intermediate filament tail domain containing protein 0.0115 0.0298 0.1086
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0064 0.0235
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.007 0.007
Giardia lamblia Hypothetical protein 0.0019 0.0002 0.0171
Brugia malayi hypothetical protein 0.0019 0.0001 0.0005
Echinococcus multilocularis tumor protein p63 0.0392 0.1152 0.1152
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0024 0.0017 0.0055
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0083 0.0199 0.0725
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.0627 0.2003
Plasmodium vivax glutathione reductase, putative 0.0047 0.0089 0.2471
Giardia lamblia Hypothetical protein 0.0019 0.0002 0.0171
Loa Loa (eye worm) hypothetical protein 0.0027 0.0027 0.0097
Loa Loa (eye worm) hypothetical protein 0.0131 0.0346 0.1263
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0024 0.0017 0.0063
Entamoeba histolytica hypothetical protein 0.0042 0.0072 0.1146
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0007 0.0026
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0128 0.0408
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0131 0.0346 0.448
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0 0.0001
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0196 0.0546 0.0546
Schistosoma mansoni aldehyde dehydrogenase 0.0269 0.0773 0.1785
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0064 0.0064
Echinococcus granulosus metabotropic glutamate receptor 2 0.0137 0.0367 0.0367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.014 0.2227
Brugia malayi phosphofructokinase 0.0222 0.0627 0.2286
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0026 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0019 0.0303
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.007 0.007
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0061 0.0131 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0027 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Brugia malayi EGF-like domain containing protein 0.0048 0.0091 0.0333
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0131 0.0346 0.0346
Echinococcus multilocularis excitatory amino acid transporter 2 0.0247 0.0706 0.0706
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0287 0.0826 0.0826
Entamoeba histolytica hypothetical protein, conserved 0.0061 0.013 0.2072
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0064 0.0149
Schistosoma mansoni ap endonuclease 0.0061 0.0131 0.0301
Brugia malayi regulator of G-protein signaling rgs-7 0.0041 0.007 0.0257
Echinococcus granulosus excitatory amino acid transporter 2 0.0247 0.0706 0.0706
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0011 0.0011
Echinococcus granulosus slit 2 protein 0.0048 0.0091 0.0091
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0089 0.0089
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.007 0.007
Entamoeba histolytica phosphofructokinase, putative 0.0222 0.0627 1
Plasmodium vivax hypothetical protein, conserved 0.0061 0.013 0.3672
Loa Loa (eye worm) hypothetical protein 0.0061 0.013 0.0474
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.014 0.2227
Loa Loa (eye worm) hypothetical protein 0.0061 0.013 0.0474
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0056 0.0114 0.0114
Echinococcus granulosus tissue type plasminogen activator 0.0025 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0064 0.0235
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0061 0.013 0.1679
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Loa Loa (eye worm) ATP-dependent DNA helicase 0.004 0.0068 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Entamoeba histolytica hypothetical protein 0.0042 0.0072 0.1146
Toxoplasma gondii phosphofructokinase domain-containing protein 0.006 0.0128 0.1653
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0061 0.0131 0.0218
Loa Loa (eye worm) cytochrome P450 family protein 0.0076 0.0177 0.0647
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.011 0.0281 0.0649
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.0257
Chlamydia trachomatis endonuclease IV 0.0083 0.0199 0.2801
Entamoeba histolytica hypothetical protein 0.0042 0.0072 0.1146
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0062 0.0985
Onchocerca volvulus 0.0061 0.013 0.0415
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.007 0.0163
Loa Loa (eye worm) glutamate receptor 0.0058 0.0123 0.0448
Loa Loa (eye worm) glutathione reductase 0.0047 0.0089 0.0324
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0041 0.007 0.007
Treponema pallidum 76K protein 0.0061 0.013 0.0217
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0046 0.0084 0.1091
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0007 0.0015
Leishmania major trypanothione reductase 0.0047 0.0089 0.1148
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0041 0.007 0.0225
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.014 0.2227
Brugia malayi PXA domain containing protein 0.0041 0.007 0.0257
Entamoeba histolytica hypothetical protein 0.0041 0.007 0.1124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0064 0.0235
Brugia malayi nuclear receptor RXR 0.0019 0 0.0001
Brugia malayi nuclear receptor NHR-88 0.0039 0.0064 0.0235
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0275 0.3547
Brugia malayi Bloom's syndrome protein homolog 0.0067 0.0148 0.054
Echinococcus granulosus expressed protein 0.0037 0.0058 0.0058
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0131 0.6367
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0128 0.0408
Schistosoma mansoni lipoxygenase 0.0062 0.0133 0.0307
Brugia malayi Kringle domain containing protein 0.0025 0.0019 0.0069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0026
Mycobacterium ulcerans 6-phosphofructokinase 0.0222 0.0627 0.8102
Echinococcus multilocularis dnaJ subfamily B 0.0456 0.1349 0.1349
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0275 0.3547
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Schistosoma mansoni lozenge 0.0056 0.0114 0.0264
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0071 0.0071
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0084 0.0201 0.0201
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.007 0.007
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0068 0.0879
Schistosoma mansoni glutamate receptor kainate 0.0117 0.0305 0.0703
Echinococcus granulosus Excitatory amino acid transporter 0.0247 0.0706 0.0706
Onchocerca volvulus 0.0061 0.013 0.0415
Schistosoma mansoni laminin gamma-3 chain 0.0048 0.0091 0.0211
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0025 0.0019 0.0433
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0048 0.0091 0.0333
Echinococcus granulosus nmda type glutamate receptor 0.0027 0.0027 0.0027
Echinococcus granulosus 6 phosphofructokinase 0.0222 0.0627 0.0627
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0105 0.0268 0.0268
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0167 0.0386
Entamoeba histolytica hypothetical protein 0.0041 0.007 0.1124
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.007 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0064 0.0235
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Trypanosoma cruzi extracellular receptor, putative 0.0027 0.0027 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0041 0.007 0.0257
Loa Loa (eye worm) follicle stimulating hormone receptor 0.048 0.1424 0.5191
Loa Loa (eye worm) hypothetical protein 0.004 0.0068 0.0247
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0051 0.0101 0.0367
Brugia malayi Receptor family ligand binding region containing protein 0.0051 0.0101 0.0367
Brugia malayi Thioredoxin reductase 0.0047 0.0089 0.0324
Brugia malayi metabotropic glutamate receptor type 2 0.0085 0.0206 0.0753
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0084 0.0201 0.0201
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0062 0.0985
Onchocerca volvulus 0.0027 0.0027 0.0085
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.006 0.0128 0.0214
Schistosoma mansoni cpg binding protein 0.0032 0.0042 0.0096
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0007 0.0105
Toxoplasma gondii thioredoxin reductase 0.0047 0.0089 0.1148
Trichomonas vaginalis DNA helicase recq, putative 0.0067 0.0148 0.0473
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0064 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0062 0.0197
Echinococcus multilocularis neutral amino acid transporter A 0.0247 0.0706 0.0706
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0062 0.0143
Brugia malayi intermediate filament protein 0.0115 0.0298 0.1086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.014 0.2227
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0064 0.0235
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0131 0.0346 0.08
Mycobacterium ulcerans endonuclease IV 0.0083 0.0199 0.2556
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0346 0.08
Echinococcus granulosus neurogenic locus notch protein 0.0048 0.0091 0.0091
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0062 0.0133 0.0133
Entamoeba histolytica hypothetical protein, conserved 0.0061 0.013 0.2072
Loa Loa (eye worm) hypothetical protein 0.0027 0.0027 0.0097
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.007 0.007
Loa Loa (eye worm) leukotriene A4 hydrolase 0.012 0.0313 0.1141
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.001 0.0112
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0062 0.0143
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0163 0.2607
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Echinococcus multilocularis geminin 0.0189 0.0525 0.0525
Echinococcus granulosus histone lysine methyltransferase setb 0.0131 0.0346 0.0346
Entamoeba histolytica elongation factor-2 kinase, putative 0.0061 0.013 0.2072
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.004 0.0068 0.0247
Schistosoma mansoni tyrosine kinase 0.0027 0.0027 0.0061
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0061 0.0131 0.2083
Leishmania major hypothetical protein, conserved 0.0029 0.0033 0.0431
Toxoplasma gondii endonuclease IV APN 0.0083 0.0199 0.2572
Mycobacterium ulcerans sulfatase 0.0019 0.0002 0.0007
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0 0.0001
Schistosoma mansoni hypothetical protein 0.0189 0.0525 0.1213
Brugia malayi von Willebrand factor type A domain containing protein 0.0061 0.013 0.0474
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0062 0.0062
Echinococcus granulosus ATP dependent DNA helicase Q5 0.004 0.0068 0.0068
Loa Loa (eye worm) glutamate receptor 2 0.0057 0.0118 0.0429
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.007 0.007
Toxoplasma gondii microneme protein MIC2 0.0061 0.013 0.1679
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.012 0.0313 0.0722
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0068 0.0876
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0007 0.0007
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0269 0.0773 0.0773
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0019 0.0002 0.0007
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0222 0.0627 0.8102
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0064 0.0235
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0027 0.0027 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0128 0.0408
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.007 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Onchocerca volvulus 0.0061 0.013 0.0415
Echinococcus multilocularis tyrosine kinase 0.0027 0.0027 0.0027
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0037 0.0058 0.0211
Brugia malayi glutathione reductase 0.0047 0.0089 0.0324
Loa Loa (eye worm) 6-phosphofructokinase 0.0222 0.0627 0.2286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.014 0.2227
Schistosoma mansoni glutamate receptor kainate 0.0057 0.0118 0.0272
Schistosoma mansoni hypothetical protein 0.0061 0.013 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.007 0.007
Brugia malayi nuclear receptor NHR-67 0.0019 0 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.007 0.0225
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0064 0.0064
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.004 0.0068 0.0068
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0064 0.0235
Entamoeba histolytica hypothetical protein 0.0042 0.0072 0.1146
Entamoeba histolytica phosphofructokinase, putative 0.0222 0.0627 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0064 0.0235
Echinococcus multilocularis Excitatory amino acid transporter 0.0247 0.0706 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Echinococcus granulosus cpg binding protein 0.0034 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0061 0.013 0.03
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0024
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0163 0.2607
Echinococcus granulosus voltage dependent calcium channel subunit 0.1484 0.4517 0.4517
Schistosoma mansoni hypothetical protein 0.0287 0.0826 0.1908
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.014 0.2227
Brugia malayi von Willebrand factor type A domain containing protein 0.0061 0.013 0.0474
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0061 0.013 0.0415
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0061 0.013 0.3672
Brugia malayi hypothetical protein 0.0272 0.0782 0.2852
Echinococcus multilocularis Excitatory amino acid transporter 0.0247 0.0706 0.0706
Echinococcus multilocularis expressed protein 0.0805 0.2423 0.2423
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0072 0.0166
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0128 0.1791
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0247 0.0706 0.1629
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0058 0.0185
Schistosoma mansoni DNA helicase recq1 0.004 0.0068 0.0156
Entamoeba histolytica recQ family helicase, putative 0.002 0.0004 0.0067
Echinococcus multilocularis beta adrenergic receptor kinase 0.0041 0.007 0.007
Echinococcus granulosus intermediate filament protein 0.0115 0.0298 0.0298
Brugia malayi hypothetical protein 0.0021 0.0007 0.0026
Schistosoma mansoni axis inhibition protein axin 0.0041 0.007 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.0257
Loa Loa (eye worm) hypothetical protein 0.0041 0.007 0.0257
Plasmodium falciparum thioredoxin reductase 0.0047 0.0089 0.4143
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0128 0.3611
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.0627 0.2003
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0163 0.0596
Onchocerca volvulus 0.0022 0.0011 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.007 0.0225
Echinococcus multilocularis pikachurin 0.0048 0.0091 0.0091
Trichomonas vaginalis rotamase, putative 0.0036 0.0055 0.0176
Schistosoma mansoni hypothetical protein 0.0025 0.0019 0.0044
Onchocerca volvulus 0.0025 0.0019 0.0061
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0199 0.5689
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0163 0.2607
Echinococcus granulosus sodium:dicarboxylate symporter 0.0247 0.0706 0.0706
Brugia malayi hypothetical protein 0.0019 0 0.0001
Brugia malayi von Willebrand factor type A domain containing protein 0.0061 0.013 0.0474
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.004 0.0068 0.0247
Brugia malayi hypothetical protein 0.0108 0.0275 0.1001
Loa Loa (eye worm) CUTiclin family member 0.0061 0.013 0.0474
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0055 0.088
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0036 0.0055 0.0713
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0064 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.014 0.2227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0064 0.0235
Trichomonas vaginalis phosphofructokinase, putative 0.0222 0.0627 0.2003
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0064 0.0235
Plasmodium falciparum glutathione reductase 0.0047 0.0089 0.4143
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Trichomonas vaginalis set domain proteins, putative 0.1033 0.3129 1
Onchocerca volvulus 0.0057 0.012 0.0384
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0026 0.0022 0.0022
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.006 0.0128 0.2039
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0064 0.0064
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.001 0.0038
Loa Loa (eye worm) hypothetical protein 0.0196 0.0546 0.1992
Brugia malayi Zona pellucida-like domain containing protein 0.0061 0.013 0.0474
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0002 0.0007
Schistosoma mansoni regulator of G protein signaling 0.0041 0.007 0.0163
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0312 0.4028
Schistosoma mansoni cpg binding protein 0.0034 0.0047 0.0109
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0019 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0053 0.0108 0.0393
Echinococcus multilocularis excitatory amino acid transporter 3 0.0247 0.0706 0.0706
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0247 0.0706 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0025 0.0019 0.0069
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0083 0.0199 0.2556
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0144 0.0388 0.0388
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0036 0.0055 0.088
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.001 0.0033
Toxoplasma gondii kringle domain-containing protein 0.0025 0.0019 0.0246
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0071 0.0071
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0064 0.0064
Echinococcus multilocularis tissue type plasminogen activator 0.0025 0.0019 0.0019
Schistosoma mansoni rab6-interacting 0.0022 0.0011 0.0025
Chlamydia trachomatis neutral amino acid transporter 0.011 0.0281 0.3968
Chlamydia trachomatis glutamate symporter 0.0247 0.0706 1
Loa Loa (eye worm) hypothetical protein 0.0019 0 0.0001
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0041 0.007 0.0257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0064 0.0235
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0125 0.0329 0.0329
Echinococcus multilocularis RUN 0.0022 0.0011 0.0011

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 94 uM Inhibition of human beta-secretase(BACE) in MBP-C125 assay ChEMBL. 12723942
IC50 (binding) = 94 uM Inhibition of human beta-secretase(BACE) in MBP-C125 assay ChEMBL. 12723942

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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