Detailed information for compound 76751

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 192.175 | Formula: C8H8N4O2
  • H donors: 1 H acceptors: 3 LogP: -0.77 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1n[n+]([O-])c2c([n+]1[O-])c(C)ccc2
  • InChi: 1S/C8H8N4O2/c1-5-3-2-4-6-7(5)11(13)8(9)10-12(6)14/h2-4H,1H3,(H2,9,10)
  • InChiKey: UKZBIYWCEDHBQX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0076 0.0072
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.021 0.229
Leishmania major cathepsin L-like protease 0.0064 0.0181 0.1965
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0076 0.0228
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0076 0.0167
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0154 0.015
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0011 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0076 0.0228
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0216
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0101
Schistosoma mansoni coup transcription factor 0.0037 0.0076 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0076 0.0216
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0076 0.0167
Leishmania major extracellular receptor, putative 0.0027 0.0038 0.0373
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0001
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0119 0.1504
Onchocerca volvulus 0.0048 0.0119 0.0302
Echinococcus multilocularis glutamate receptor 2 0.0058 0.0159 0.0155
Brugia malayi Glutamate receptor 2 precursor 0.0057 0.0153 0.0459
Treponema pallidum ATP-dependent DNA helicase 0.002 0.0009 0.0005
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0048 0.0119 0.0344
Plasmodium vivax glutathione reductase, putative 0.0048 0.0117 0.2649
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0076 0.0072
Loa Loa (eye worm) hypothetical protein 0.0048 0.0119 0.0344
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0081 0.0179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0181 0.2319
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0047 0.013
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0081 0.0179
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0041 0.009 0.2005
Echinococcus multilocularis thyroid hormone receptor alpha 0.0303 0.1109 0.1105
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0251 0.0905 0.0901
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0076 0.0072
Onchocerca volvulus 0.0048 0.0119 0.0302
Echinococcus multilocularis 6 phosphofructokinase 0.0215 0.0767 0.0764
Echinococcus granulosus geminin 0.0175 0.0613 0.0609
Brugia malayi phosphofructokinase 0.0215 0.0767 0.2295
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0127 0.0423 0.042
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0072 0.0178
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0076 0.0167
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0072 0.0068
Echinococcus granulosus Excitatory amino acid transporter 0.0249 0.0899 0.0895
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0117 0.0113
Loa Loa (eye worm) hypothetical protein 0.0048 0.012 0.0348
Loa Loa (eye worm) RGC/RGC protein kinase 0.0027 0.0038 0.0101
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0048 0.0119 0.2703
Plasmodium falciparum cysteine repeat modular protein 1 0.0023 0.0021 0.0401
Echinococcus granulosus cpg binding protein 0.0031 0.0054 0.005
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0249 0.0899 0.0895
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0087 0.0918
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0081 0.0179
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0101
Plasmodium vivax thrombospondin-related anonymous protein 0.0048 0.0119 0.2703
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.0905 1
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1357 0.52 1
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0158 0.0404
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0158 0.0471
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0093 0.0089
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0026 0.0032 0.0028
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0076 0.0228
Echinococcus multilocularis Protein lozenge 0.0056 0.0149 0.0145
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0181 0.2319
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0083 0.0255 0.279
Trypanosoma brucei trypanothione reductase 0.0048 0.0117 0.1474
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0181 0.2319
Schistosoma mansoni serine-rich repeat protein 0.0609 0.2297 0.5307
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0104 0.1311
Leishmania major hypothetical protein, conserved 0.0027 0.0037 0.037
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0027 0.0038 0.0089
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.0006 0.0027
Schistosoma mansoni hypothetical protein 0.0609 0.2297 0.5307
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0081 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0076 0.0228
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.0905 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0158 0.9998
Brugia malayi Cache domain containing protein 0.0522 0.1959 0.5858
Schistosoma mansoni hypothetical protein 0.0175 0.0613 0.1409
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0158 0.1706
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0081 0.0179
Schistosoma mansoni glutamate receptor NMDA 0.0057 0.0153 0.0346
Trichomonas vaginalis rotamase, putative 0.0035 0.0066 0.0163
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0048 0.0119 0.0302
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0008 0.0013
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0119 0.0355
Loa Loa (eye worm) CUTiclin family member 0.0048 0.0119 0.0344
Schistosoma mansoni metabotropic glutamate receptor 0.0138 0.0468 0.1074
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0076 0.0228
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.0767 1
Loa Loa (eye worm) glutamate receptor 0.0162 0.0562 0.167
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0076 0.0167
Mycobacterium ulcerans endonuclease IV 0.0083 0.0255 0.279
Toxoplasma gondii microneme protein MIC2 0.0048 0.0119 0.1274
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0081 0.0077
Brugia malayi metabotropic glutamate receptor type 2 0.0086 0.0265 0.0793
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0158 0.0404
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0249 0.0899 0.9931
Toxoplasma gondii kringle domain-containing protein 0.0023 0.0021 0.0187
Trichomonas vaginalis DNA helicase recq1, putative 0.0065 0.0185 0.0475
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0158 0.1696
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0353 0.3878
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0128 0.162
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0249 0.0899 0.2348
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.0905 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0084 0.0259 0.0255
Brugia malayi hypothetical protein 0.023 0.0826 0.247
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0076 0.019
Loa Loa (eye worm) phosphofructokinase 0.0215 0.0767 0.2286
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0037 0.037
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0215 0.0767 1
Loa Loa (eye worm) hypothetical protein 0.0522 0.1959 0.5854
Brugia malayi Pre-SET motif family protein 0.0879 0.3344 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.0203
Onchocerca volvulus 0.0048 0.0119 0.0302
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0259 0.0937 0.216
Loa Loa (eye worm) hypothetical protein 0.0197 0.0695 0.2071
Schistosoma mansoni laminin gamma-3 chain 0.0048 0.012 0.0268
Onchocerca volvulus 0.0127 0.0423 0.1101
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.006 0.0164 0.6256
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0153 0.0346
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0259 0.0937 0.0933
Loa Loa (eye worm) RecQ helicase 0.0065 0.0185 0.0542
Schistosoma mansoni lamin 0.0082 0.0251 0.0572
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0154 0.015
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0081 0.0243
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0138 0.0468 0.0464
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0216
Echinococcus multilocularis tissue type plasminogen activator 0.0023 0.0021 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0076 0.0228
Schistosoma mansoni cpg binding protein 0.0031 0.0054 0.0115
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.0905 0.2085
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0048 0.0119 0.0355
Echinococcus granulosus neutral amino acid transporter 0.0249 0.0899 0.0895
Schistosoma mansoni DNA helicase recq1 0.0039 0.0083 0.0183
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0037 0.0751
Entamoeba histolytica recQ family helicase, putative 0.0044 0.0104 0.1311
Loa Loa (eye worm) hypothetical protein 0.0082 0.0251 0.0741
Loa Loa (eye worm) abnormal epIthelia family member 0.0048 0.012 0.0348
Brugia malayi hypothetical protein 0.002 0.0008 0.0024
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2594 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0076 0.0216
Plasmodium falciparum thrombospondin-related anonymous protein 0.0048 0.0119 0.4413
Treponema pallidum glutamate transporter 0.011 0.036 0.0682
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0117 0.0338
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0009 0.0054
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0181 0.2319
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0048 0.012 0.0268
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0072 0.4412
Loa Loa (eye worm) hypothetical protein 0.0446 0.1662 0.4965
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0081 0.0179
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0158 0.0404
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0169 0.059 0.1356
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0158 0.6
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0039 0.0083 0.0079
Echinococcus multilocularis lamin dm0 0.0082 0.0251 0.0247
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0013
Toxoplasma gondii 6-phosphofructokinase 0.0058 0.0158 0.1704
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0058 0.0158 0.0291
Echinococcus multilocularis bloom syndrome protein 0.0065 0.0185 0.0181
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.0203
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0066
Loa Loa (eye worm) hypothetical protein 0.0127 0.0423 0.1256
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0081 0.0243
Echinococcus multilocularis receptor type guanylyl cyclase 0.0027 0.0038 0.0034
Echinococcus granulosus tumor protein p63 0.0364 0.1346 0.1343
Onchocerca volvulus 0.0027 0.0038 0.0089
Loa Loa (eye worm) hypothetical protein 0.0048 0.0119 0.0344
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0158 0.2011
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0076 0.0228
Onchocerca volvulus 0.002 0.0011 0.0019
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0879 0.3344 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0181 0.2319
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1131 0.4324 1
Loa Loa (eye worm) hypothetical protein 0.023 0.0826 0.2461
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.0203
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0158 0.0403
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0216
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0081 0.0179
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.0021 0.0051
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0181 0.2319
Loa Loa (eye worm) CUTiclin-Like family member 0.0048 0.0119 0.0344
Schistosoma mansoni polycystin 1-related 0.002 0.0011 0.0016
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0072 0.0068
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0048 0.0119 0.2703
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0081 0.0077
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0081 0.0077
Echinococcus granulosus receptor type guanylyl cyclase 0.0027 0.0038 0.0034
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.04 0.5108
Loa Loa (eye worm) hypothetical protein 0.0685 0.2591 0.7746
Onchocerca volvulus 0.0023 0.0021 0.0045
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0019 0.0004 0.0001
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0076 0.0167
Schistosoma mansoni rab6-interacting 0.002 0.0011 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0076 0.0228
Echinococcus multilocularis Excitatory amino acid transporter 0.0249 0.0899 0.0895
Schistosoma mansoni glutamate receptor kainate 0.0118 0.039 0.0894
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0249 0.0899 1
Echinococcus granulosus glutamate receptor 2 0.0084 0.0259 0.0255
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0076 0.0167
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0081 0.0077
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0076 0.0216
Loa Loa (eye worm) hypothetical protein 0.0048 0.0119 0.0344
Trypanosoma cruzi extracellular receptor, putative 0.0027 0.0038 0.044
Echinococcus multilocularis nmda type glutamate receptor 0.0045 0.0106 0.0102
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0076 0.0072
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0084 0.0259 0.0255
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0076 0.0072
Loa Loa (eye worm) hypothetical protein 0.0048 0.0119 0.0344
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0353 0.3878
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0119 0.0355
Loa Loa (eye worm) hypothetical protein 0.0038 0.008 0.0228
Echinococcus granulosus neutral amino acid transporter A 0.0249 0.0899 0.0895
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0051 0.0132 0.0382
Onchocerca volvulus 0.0446 0.1662 0.4351
Loa Loa (eye worm) 6-phosphofructokinase 0.0215 0.0767 0.2286
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0158 0.3631
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0119 0.0355
Echinococcus multilocularis expressed protein 0.075 0.2843 0.284
Echinococcus multilocularis neurogenic locus notch protein 0.0048 0.012 0.0116
Echinococcus granulosus neutral amino acid transporter A 0.0249 0.0899 0.0895
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0158 0.2011
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0145 0.0496 0.0492
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0051 0.0132 0.0382
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.011 0.036 0.0825
Mycobacterium ulcerans 6-phosphofructokinase 0.0215 0.0767 0.8474
Schistosoma mansoni hypothetical protein 0.0024 0.0026 0.005
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0255 0.5971
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.0203
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0251 0.0905 1
Schistosoma mansoni 6-phosphofructokinase 0.0215 0.0767 0.1767
Schistosoma mansoni loxhd1 0.002 0.0011 0.0016
Echinococcus granulosus RUN 0.002 0.0011 0.0007
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0145 0.0496 0.0492
Brugia malayi Zona pellucida-like domain containing protein 0.0048 0.0119 0.0355
Onchocerca volvulus 0.0082 0.0251 0.0649
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0048 0.0119 0.0115
Echinococcus multilocularis tyrosine kinase 0.0027 0.0038 0.0034
Leishmania major cathepsin L-like protease 0.0064 0.0181 0.1965
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0181 0.2319
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0353 0.3878
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0076 0.0167
Brugia malayi nuclear receptor RXR 0.002 0.0008 0.0024
Echinococcus granulosus lamin dm0 0.0082 0.0251 0.0247
Brugia malayi intermediate filament protein 0.0082 0.0251 0.0751
Loa Loa (eye worm) hypothetical protein 0.0053 0.0139 0.0404
Echinococcus granulosus 6 phosphofructokinase 0.0215 0.0767 0.0764
Echinococcus multilocularis glutamate receptor 2 0.0084 0.0259 0.0255
Brugia malayi Doublecortin family protein 0.002 0.0011 0.0033
Loa Loa (eye worm) doublecortin family protein 0.002 0.0011 0.0022
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0158 0.3632
Schistosoma mansoni cpg binding protein 0.003 0.0047 0.01
Echinococcus granulosus metabotropic glutamate receptor 5 0.0197 0.0695 0.0692
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0072 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0076 0.0228
Schistosoma mansoni hypothetical protein 0.0023 0.0021 0.0039
Brugia malayi laminin alpha chain 0.0048 0.012 0.0359
Brugia malayi Metabotropic glutamate receptor precursor. 0.0162 0.0562 0.168
Brugia malayi hypothetical protein 0.0027 0.0038 0.0113
Brugia malayi von Willebrand Factor 0.0048 0.0119 0.0355
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0019 0.0004 0.0001
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0011 0.0007
Plasmodium vivax SET domain protein, putative 0.0127 0.0423 1
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.057 0.2146 0.4958
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0051
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.021 0.2703
Loa Loa (eye worm) hypothetical protein 0.0038 0.008 0.0228
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0081 0.0243
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0019 0.0004 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0076 0.0072
Schistosoma mansoni lipoxygenase 0.002 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.01
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0076 0.0167
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0063 0.0771
Chlamydia trachomatis neutral amino acid transporter 0.011 0.036 0.3968
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0037 0.1076
Schistosoma mansoni survival motor neuron protein 0.0047 0.0114 0.0255
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0039 0.0083 0.2948
Brugia malayi Glutamate receptor 1 precursor 0.0057 0.0153 0.0459
Onchocerca volvulus 0.003 0.0047 0.0114
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0057 0.0153 0.0149
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0009 0.0064
Echinococcus multilocularis excitatory amino acid transporter 2 0.0249 0.0899 0.0895
Schistosoma mansoni hypothetical protein 0.0423 0.1575 0.3637
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0017 0.0051
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0083 0.0877
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0081 0.0232
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0076 0.0072
Loa Loa (eye worm) RGC/RGC protein kinase 0.0027 0.0038 0.0101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0001
Echinococcus granulosus sodium:dicarboxylate symporter 0.0249 0.0899 0.0895
Brugia malayi hypothetical protein 0.0019 0.0004 0.0011
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0048 0.0119 0.0344
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0158 0.0154
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0076 0.0072
Schistosoma mansoni thyroid hormone receptor 0.0303 0.1109 0.2558
Echinococcus multilocularis NMDA receptor 0.0087 0.0269 0.0265
Loa Loa (eye worm) hypothetical protein 0.0048 0.0119 0.0344
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0195 0.0441
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0104 0.1111
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0081 0.0179
Brugia malayi 6-phosphofructokinase 0.0215 0.0767 0.2295
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.011 0.036 0.0357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0181 0.2319
Schistosoma mansoni rotamase 0.0035 0.0066 0.0144
Entamoeba histolytica recQ family DNA helicase 0.002 0.0009 0.0064
Treponema pallidum hypothetical protein 0.0048 0.0119 0.0217
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0081 0.0179
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0221 0.0649
Loa Loa (eye worm) hypothetical protein 0.0039 0.0081 0.0232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0181 0.2319
Echinococcus granulosus voltage dependent calcium channel subunit 0.118 0.4511 0.4509
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0081 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0076 0.0216
Onchocerca volvulus 0.1 0.3815 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0423 0.0971
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0011 0.0007
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0072 0.0068
Onchocerca volvulus Dipeptidase C homolog 0.0019 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0081 0.0232
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0037 0.0436
Echinococcus multilocularis Excitatory amino acid transporter 0.0249 0.0899 0.0895
Loa Loa (eye worm) hypothetical protein 0.0048 0.0119 0.0344
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0145 0.0496 0.0492
Onchocerca volvulus 0.0048 0.0119 0.0302
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0104 0.1311
Brugia malayi Receptor family ligand binding region containing protein 0.0027 0.0038 0.0113
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0081 0.0232
Schistosoma mansoni hypothetical protein 0.0266 0.0965 0.2224
Echinococcus granulosus nmda type glutamate receptor 0.0027 0.0038 0.0034
Brugia malayi hypothetical protein 0.0039 0.0081 0.0243
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0009 0.0064
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0076 0.019
Echinococcus granulosus glutamate receptor subunit protein glur 0.0026 0.0032 0.0028
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.1575 0.1572
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0255 1
Echinococcus granulosus excitatory amino acid transporter 3 0.0249 0.0899 0.0895
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0081 0.0077
Brugia malayi hypothetical protein 0.0446 0.1662 0.4971
Echinococcus multilocularis geminin 0.0175 0.0613 0.0609
Loa Loa (eye worm) glutamate receptor 1 0.0057 0.0153 0.0448
Echinococcus multilocularis glutamate receptor 2 0.0057 0.0153 0.0149
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.0767 0.2004
Schistosoma mansoni slit 0.0048 0.012 0.0268
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0119 0.2703
Loa Loa (eye worm) excitatory amino acid transporter 0.0249 0.0899 0.2679
Entamoeba histolytica hypothetical protein 0.0039 0.0081 0.1013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0076 0.0216
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0081 0.0232
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0076 0.0072
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0117 0.0113
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0119 0.0355
Echinococcus multilocularis expressed protein 0.0035 0.0066 0.0062
Loa Loa (eye worm) hypothetical protein 0.0048 0.012 0.0348
Leishmania major cathepsin L-like protease 0.0064 0.0181 0.1965
Brugia malayi laminin-like protein K08C7.3 precursor 0.0048 0.012 0.0359
Echinococcus granulosus pikachurin 0.0048 0.012 0.0116
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0066 0.0186
Loa Loa (eye worm) hypothetical protein 0.0046 0.0111 0.032
Brugia malayi 6-phosphofructokinase 0.0215 0.0767 0.2295
Loa Loa (eye worm) hypothetical protein 0.0039 0.0081 0.0232
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0215 0.0767 0.8474
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0076 0.0228
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0081 0.0077
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0076 0.0072
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0081 0.0243
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0081 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0076 0.0228
Schistosoma mansoni cpg binding protein 0.0031 0.0054 0.0115
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0058 0.0158 0.1704
Brugia malayi hypothetical protein 0.002 0.0008 0.0024
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.021 0.0206
Echinococcus multilocularis voltage dependent calcium channel subunit 0.118 0.4511 0.4509
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0266 0.0965 0.0961
Chlamydia trachomatis glutamate symporter 0.0249 0.0899 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0158 0.3632
Brugia malayi hypothetical protein 0.0263 0.0952 0.2848
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0158 0.6001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0251 0.0905 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0181 0.2319
Loa Loa (eye worm) hypothetical protein 0.0051 0.0132 0.0382
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.0899 0.0895
Echinococcus granulosus expressed protein 0.075 0.2843 0.284
Treponema pallidum 76K protein 0.0048 0.0119 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.0203
Entamoeba histolytica hypothetical protein 0.0039 0.0081 0.1013
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.011 0.036 0.0825
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0009 0.0011
Giardia lamblia Sgs1 DNA helicase, putative 0.0039 0.0083 0.5154
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0066 0.0198
Giardia lamblia Xaa-Pro dipeptidase 0.0019 0.0004 0.0015
Brugia malayi hypothetical protein 0.0039 0.0082 0.0247
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0081 0.0179
Schistosoma mansoni DNA helicase recq5 0.0039 0.0083 0.0183
Echinococcus granulosus nmda type glutamate receptor 0.0045 0.0106 0.0102
Onchocerca volvulus 0.0048 0.0119 0.0302
Brugia malayi PXA domain containing protein 0.0039 0.0081 0.0243
Schistosoma mansoni hypothetical protein 0.0048 0.0119 0.0266
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.0767 0.2004
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.021 0.0478
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0017 0.0145
Echinococcus granulosus intermediate filament protein 0.0082 0.0251 0.0247
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.021 0.2703
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0063 0.0653
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0024 0.0026 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0021 0.022
Entamoeba histolytica hypothetical protein 0.0039 0.0082 0.1027
Loa Loa (eye worm) glutamate receptor 2 0.0057 0.0153 0.0448
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.0899 0.0895
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0076 0.0228
Echinococcus granulosus glutamate NMDA receptor subunit 0.0057 0.0153 0.0149
Toxoplasma gondii endonuclease IV APN 0.0083 0.0255 0.2788
Trichomonas vaginalis rotamase, putative 0.0034 0.0063 0.0155
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0063 0.0771
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0017 0.0145
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0026 0.0032 0.0028
Entamoeba histolytica elongation factor-2 kinase, putative 0.0048 0.0119 0.1504
Trichomonas vaginalis set domain proteins, putative 0.1 0.3815 1
Brugia malayi hypothetical protein 0.0048 0.0119 0.0355
Brugia malayi steroid hormone receptor 0.0037 0.0076 0.0228
Schistosoma mansoni 6-phosphofructokinase 0.0215 0.0767 0.1767
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0181 0.2319
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0076 0.0167
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0076 0.0228
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0103 0.0297
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0119 0.0355
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0083 0.0877
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.04 0.4399
Echinococcus multilocularis cpg binding protein 0.0031 0.0054 0.005
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.0767 0.2004
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0145 0.0496 0.0492
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0017 0.0034
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0063 0.0771
Loa Loa (eye worm) hypothetical protein 0.0048 0.0119 0.0344
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0019 0.0004 0.0001
Echinococcus multilocularis GPCR, family 3, C terminal 0.0024 0.0026 0.0022
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0249 0.0899 0.0895
Echinococcus multilocularis excitatory amino acid transporter 3 0.0249 0.0899 0.0895
Onchocerca volvulus 0.0082 0.0251 0.0649
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0013
Schistosoma mansoni metabotropic glutamate receptor 0.0086 0.0265 0.0605
Echinococcus granulosus excitatory amino acid transporter 2 0.0249 0.0899 0.0895
Onchocerca volvulus 0.0037 0.0076 0.019
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0024 0.0026 0.0077
Onchocerca volvulus Poor gastrulation protein homolog 0.0024 0.0026 0.0058
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0083 0.0249
Brugia malayi Pre-SET motif family protein 0.0127 0.0423 0.1266
Mycobacterium ulcerans hypothetical protein 0.0022 0.0017 0.0145
Loa Loa (eye worm) hypothetical protein 0.0039 0.0081 0.0232
Brugia malayi ecdysteroid receptor 0.0037 0.0076 0.0228
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0072 0.0751
Schistosoma mansoni blooms syndrome DNA helicase 0.0045 0.0108 0.024
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0019 0.0004 0.0001
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0019 0.0004 0.0001
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0081 0.0077
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0081 0.0179
Schistosoma mansoni hypothetical protein 0.0039 0.0082 0.0181
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0181 0.2319
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0008 0.0024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0076 0.0072
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0083 0.0255 0.3176
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0076 0.0228
Loa Loa (eye worm) hypothetical protein 0.0446 0.1662 0.4965
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0048 0.0119 0.0344
Chlamydia trachomatis endonuclease IV 0.0083 0.0255 0.279
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0081 0.0077
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0081 0.0077
Echinococcus granulosus lamin 0.0082 0.0251 0.0247
Echinococcus granulosus expressed protein 0.0035 0.0066 0.0062
Echinococcus granulosus GPCR family 3 C terminal 0.0024 0.0026 0.0022
Echinococcus granulosus glutamate receptor 2 0.0058 0.0159 0.0155
Echinococcus granulosus bloom syndrome protein 0.0065 0.0185 0.0181
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0117 0.1474
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0159 0.2036
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0008 0.0009
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.0767 1
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0158 0.0404
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0081 0.0179
Echinococcus granulosus excitatory amino acid transporter 2 0.0249 0.0899 0.0895
Brugia malayi hypothetical protein 0.0119 0.0394 0.1178
Brugia malayi Thioredoxin reductase 0.0048 0.0117 0.0349
Echinococcus multilocularis nmda type glutamate receptor 0.0027 0.0038 0.0034
Loa Loa (eye worm) hypothetical protein 0.0048 0.0119 0.0344
Brugia malayi Protein kinase domain containing protein 0.0023 0.0021 0.0062
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0027 0.0038 0.0101
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0215 0.0767 1
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0083 0.0255 0.0763
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.021 0.2703
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0081 0.0077
Brugia malayi PXA domain containing protein 0.0039 0.0081 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0076 0.0228
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0104 0.0263
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0081 0.0077
Entamoeba histolytica hypothetical protein 0.0039 0.0081 0.1013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0471 0.176 0.5258
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0048 0.0119 0.2703
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0117 0.2649
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0072 0.0157
Echinococcus granulosus atrial natriuretic peptide receptor 0.0027 0.0038 0.0034
Loa Loa (eye worm) hypothetical protein 0.0048 0.0119 0.0344
Echinococcus multilocularis lamin 0.0082 0.0251 0.0247
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0251 0.0741
Trichomonas vaginalis DNA helicase recq, putative 0.0065 0.0185 0.0475
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0076 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0072 0.0178
Brugia malayi CXXC zinc finger family protein 0.003 0.0047 0.0141
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0008 0.0024
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0114 0.0342
Echinococcus granulosus histone lysine methyltransferase setb 0.0127 0.0423 0.042
Brugia malayi nuclear hormone receptor 0.0037 0.0076 0.0228
Brugia malayi EGF-like domain containing protein 0.0048 0.012 0.0359
Echinococcus granulosus metabotropic glutamate receptor 2 0.0138 0.0468 0.0464
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0251 0.0751
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.0905 0.2085
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0072 0.0886
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0106 0.0344 0.034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0181 0.2319
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0072 0.0068
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.021 0.0629
Loa Loa (eye worm) glutamate receptor 0.0059 0.0159 0.0466
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0158 0.0291
Schistosoma mansoni protein kinase 0.0027 0.0038 0.0078
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0011 0.0007
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.04 0.4399
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0081 0.0243
Leishmania major ATP-dependent phosphofructokinase 0.0215 0.0767 0.8474
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0423 0.0971
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0158 0.0404
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0081 0.0243
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0019 0.0004 0.0001
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0197 0.0695 0.0692
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0153 0.0346
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0101
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0119 0.0355
Echinococcus granulosus tyrosine kinase 0.0027 0.0038 0.0034
Schistosoma mansoni intermediate filament proteins 0.0082 0.0251 0.0572
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0081 0.0179
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0119 0.0355
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0072 0.0886
Entamoeba histolytica hypothetical protein 0.0039 0.0082 0.1027
Entamoeba histolytica hypothetical protein 0.0039 0.0082 0.1027
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0127 0.0423 0.042
Loa Loa (eye worm) runx1 0.0056 0.0149 0.0434
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0081 0.0077
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0158 0.2011
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0027 0.0038 0.0034
Brugia malayi hypothetical protein 0.002 0.0011 0.0033
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0251 0.0905 0.0901
Brugia malayi nuclear receptor NHR-88 0.0037 0.0076 0.0228
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.0767 1
Schistosoma mansoni tyrosine kinase 0.0027 0.0038 0.0078
Entamoeba histolytica hypothetical protein 0.0048 0.0119 0.1504
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0216
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0119 0.1504
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0076 0.019
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0076 0.0072
Onchocerca volvulus 0.0048 0.0119 0.0302
Loa Loa (eye worm) hypothetical protein 0.0083 0.0255 0.0753
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0158 0.6001
Onchocerca volvulus 0.0047 0.0114 0.029
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0145 0.0496 0.0492
Schistosoma mansoni lamin 0.0082 0.0251 0.0572
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0039 0.0083 0.0079
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0039
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0011 0.0007
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0087 0.0269 0.0265
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0087 0.0269 0.0265
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0008 0.0004
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0086 0.0082
Schistosoma mansoni thyroid hormone receptor 0.0303 0.1109 0.2558
Onchocerca volvulus 0.0027 0.0038 0.0089
Brugia malayi Receptor family ligand binding region containing protein 0.0051 0.0132 0.0393
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0072 0.0178
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0158 0.1696
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0048 0.0119 0.4413
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0086 0.0082
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.021 0.0206
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0215 0.0767 0.1466
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0013
Loa Loa (eye worm) RGC/RGC protein kinase 0.0027 0.0038 0.0101
Loa Loa (eye worm) hypothetical protein 0.004 0.0086 0.0246
Loa Loa (eye worm) hypothetical protein 0.0048 0.0119 0.0344
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0119 0.0355
Brugia malayi von Willebrand factor type A domain containing protein 0.0048 0.0119 0.0355
Brugia malayi hypothetical protein 0.002 0.0011 0.0033
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0026 0.0032 0.0028
Loa Loa (eye worm) glutathione reductase 0.0048 0.0117 0.0338
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0037 0.0436
Echinococcus multilocularis slit 2 protein 0.0048 0.012 0.0116
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0037 0.1076
Echinococcus multilocularis tumor protein p63 0.0364 0.1346 0.1343
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0023 0.0021 0.0356
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0063 0.0771
Schistosoma mansoni glutamate receptor NMDA 0.0084 0.0259 0.059
Loa Loa (eye worm) hypothetical protein 0.0036 0.0072 0.0203
Mycobacterium tuberculosis Probable reductase 0.0109 0.0353 0.3878
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0039 0.0083 0.0237
Schistosoma mansoni lipoxygenase 0.0057 0.0154 0.0346
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0216
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0103 0.0308
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0101
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0127 0.0423 0.4655
Echinococcus granulosus tissue type plasminogen activator 0.0023 0.0021 0.0017
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0081 0.0077
Onchocerca volvulus 0.0048 0.0119 0.0302
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0011 0.0007
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0215 0.0767 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0245 0.0723
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.0767 0.2004
Echinococcus granulosus leukotriene A 4 hydrolase 0.0259 0.0937 0.0933
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0181 0.2319
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0145 0.0496 0.0492
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0127 0.0423 0.0971
Toxoplasma gondii exonuclease III APE 0.0058 0.0158 0.1704
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0082 0.0181
Schistosoma mansoni tyrosine kinase 0.0027 0.0038 0.0078
Brugia malayi Sulfatase family protein 0.0019 0.0004 0.0011
Echinococcus granulosus slit 2 protein 0.0048 0.012 0.0116
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0135 0.0456 0.1364
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0249 0.0899 0.2071
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0266 0.0965 0.0961
Schistosoma mansoni hypothetical protein 0.0026 0.0032 0.0065
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0826 0.0822
Brugia malayi Kringle domain containing protein 0.0023 0.0021 0.0062
Brugia malayi glutathione reductase 0.0048 0.0117 0.0349
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0081 0.0179
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.0899 0.0895
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0058 0.0158 0.0404
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0216
Onchocerca volvulus 0.0053 0.0139 0.0354
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0082 0.0078
Loa Loa (eye worm) 6-phosphofructokinase 0.0215 0.0767 0.2286
Schistosoma mansoni ATP-binding cassette transporter 0.0057 0.0153 0.0346
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0169 0.1825
Schistosoma mansoni glutamate receptor kainate 0.0057 0.0153 0.0346
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0022
Echinococcus granulosus neurogenic locus notch protein 0.0048 0.012 0.0116
Loa Loa (eye worm) hypothetical protein 0.0048 0.0119 0.0344
Schistosoma mansoni lozenge 0.0056 0.0149 0.0335
Schistosoma mansoni cell polarity protein 0.0048 0.012 0.0268
Leishmania major hypothetical protein, conserved 0.0023 0.0021 0.0187
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0076 0.0216
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0019 0.0004 0.0001
Brugia malayi hypothetical protein 0.0039 0.0081 0.0243
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0072 0.0886
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0081 0.0232
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0158 0.0404
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0039 0.0083 0.0079
Plasmodium falciparum thioredoxin reductase 0.0048 0.0117 0.4321
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0081 0.0077
Loa Loa (eye worm) hypothetical protein 0.0048 0.0119 0.0344
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0087 0.0269 0.0265
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0081 0.0077
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0006 0.0027
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0048 0.012 0.0359
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0058 0.0158 1
Brugia malayi Cytochrome P450 family protein 0.0074 0.0221 0.066
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0081 0.0077
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0251 0.0741
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0158 0.1704
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0093 0.0089
Entamoeba histolytica hypothetical protein 0.0039 0.0082 0.1027
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0353 0.3878
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0058 0.0158 0.2011
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0826 0.0822
Entamoeba histolytica hypothetical protein 0.0027 0.0038 0.044
Schistosoma mansoni rab6-interacting 0.002 0.0011 0.0016
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.04 0.4399
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0076 0.0072
Loa Loa (eye worm) hypothetical protein 0.0039 0.0083 0.0237
Echinococcus multilocularis excitatory amino acid transporter 2 0.0249 0.0899 0.0895
Loa Loa (eye worm) hypothetical protein 0.0039 0.0081 0.0232
Echinococcus granulosus dnaJ subfamily B 0.0423 0.1575 0.1572
Brugia malayi metallopeptidase family M24 containing protein 0.0019 0.0004 0.0012
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0006 0.0026
Schistosoma mansoni hypothetical protein 0.002 0.0011 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0158 0.0403
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0158 0.1706
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0039 0.0083 0.0079
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0101
Schistosoma mansoni hypothetical protein 0.0048 0.0119 0.0266
Schistosoma mansoni ap endonuclease 0.0058 0.0158 0.0355
Echinococcus multilocularis sodium:dicarboxylate symporter 0.011 0.036 0.0357
Echinococcus granulosus Excitatory amino acid transporter 0.0249 0.0899 0.0895
Toxoplasma gondii aldehyde dehydrogenase 0.0251 0.0905 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.0203
Brugia malayi Zona pellucida-like domain containing protein 0.0048 0.0119 0.0355
Schistosoma mansoni glutamate receptor kainate 0.0118 0.039 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0076 0.0228
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0081 0.0077
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0072 0.0214
Treponema pallidum glutamate/aspartate transporter 0.011 0.036 0.0682
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0158 0.0154
Echinococcus multilocularis RUN 0.002 0.0011 0.0007
Brugia malayi Excitatory amino acid transporter 0.0249 0.0899 0.2688
Brugia malayi hypothetical protein 0.0027 0.0037 0.0112
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0048 0.0119 0.1274
Brugia malayi Bloom's syndrome protein homolog 0.0065 0.0185 0.0553
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0158 0.2011
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0027 0.0038 0.0113
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0083 0.0249
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0082 0.0078
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0076 0.0216
Mycobacterium ulcerans epimerase 0.0022 0.0017 0.0145
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0181 0.2319
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0139 0.0312
Echinococcus multilocularis pikachurin 0.0048 0.012 0.0116
Toxoplasma gondii thioredoxin reductase 0.0048 0.0117 0.1249
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0081 0.0232
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0423 0.0971
Leishmania major trypanothione reductase 0.0048 0.0117 0.1249
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0117 0.1251
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0072 0.0157
Onchocerca volvulus 0.002 0.0011 0.0019
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.319 0.3187
Schistosoma mansoni hypothetical protein 0.0047 0.0114 0.0255
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0076 0.0072
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0353 0.3878
Toxoplasma gondii phosphofructokinase PFKII 0.0058 0.0158 0.1704
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0037 0.0436
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0039 0.0081 0.0232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0076 0.0216
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.021 0.2703
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0081 0.0179
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0072 0.0886
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0121 0.0403 0.0399
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0076 0.0072
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0076 0.0167
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0063 0.0653
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.021 0.0618
Schistosoma mansoni hypothetical protein 0.0175 0.0613 0.1409
Brugia malayi follicle stimulating hormone receptor 0.0471 0.176 0.5264
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0072 0.0068
Schistosoma mansoni ap endonuclease 0.0058 0.0158 0.0355
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0101
Plasmodium falciparum glutathione reductase 0.0048 0.0117 0.4321
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0076 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0066 0.0163
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0022
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0259 0.0937 0.2794
Echinococcus granulosus collagen alpha 1VII chain 0.0048 0.0119 0.0115
Brugia malayi Guanylyl cyclase protein 23 0.0027 0.0038 0.0113
Loa Loa (eye worm) hypothetical protein 0.0048 0.012 0.0348
Loa Loa (eye worm) hypothetical protein 0.0048 0.0119 0.0344
Echinococcus multilocularis musashi 0.0082 0.0251 0.0247
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0013
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0353 0.4481
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0048 0.0119 0.4413
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0158 0.046

Activities

Activity type Activity value Assay description Source Reference
C10 (functional) = 38.1 uM Concentration required to reduce plating efficiency to 10 percent of controls, under hypoxic conditions in mouse SCCVII tumor cells. ChEMBL. 12502371
C10 (functional) < 381 uM Concentration required to reduce plating efficiency to 10 percent of controls, under aerobic conditions in mouse SCCVII tumor cells. ChEMBL. 12502371
HCR (functional) < 10 Intraexperimental difference between the hypoxic and aerobic cytotoxicity ChEMBL. 12502371
RHT (functional) = 0.27 Intraexperimental ratio of hypoxic TPZ C10 to hypoxic BTO C10 in mouse SCCVII tumor cells. ChEMBL. 12502371

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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