Detailed information for compound 769452

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 455.542 | Formula: C25H26FNO4S
  • H donors: 1 H acceptors: 2 LogP: 3.33 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOCCOC(=C1C(=NC2=C(C1c1ccccc1F)C(=O)CC(C2)c1cccs1)C)O
  • InChi: 1S/C25H26FNO4S/c1-3-30-10-11-31-25(29)22-15(2)27-19-13-16(21-9-6-12-32-21)14-20(28)24(19)23(22)17-7-4-5-8-18(17)26/h4-9,12,16,23,29H,3,10-11,13-14H2,1-2H3
  • InChiKey: OIQURVDURRWNEL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0016 0.0034 0.0034
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0153 0.3646 0.9252
Echinococcus multilocularis hexokinase type 2 0.0148 0.35 0.444
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0034 0.0043
Mycobacterium ulcerans hypothetical protein 0.0031 0.0433 0.1186
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0016 0.0034 0.0043
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0009 0.0012
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.008 0.1713 0.2692
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0106 0.0134
Onchocerca volvulus Alhambra homolog 0.0026 0.0304 0.0271
Leishmania major modification methylase-like protein 0.0017 0.0057 0.0089
Entamoeba histolytica rodhanase-like domain containing protein 0.0043 0.0747 0.1095
Brugia malayi ImpB/MucB/SamB family protein 0.0101 0.2257 0.2257
Trypanosoma cruzi DNA polymerase kappa, putative 0.0123 0.2856 0.4489
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0087 0.19 0.4819
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0106 0.0072
Trypanosoma cruzi DNA damage repair protein, putative 0.0031 0.0433 0.068
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0784 0.1232
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0106 0.0134
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.002 0.0151 0.0192
Echinococcus granulosus chromobox protein 1 0.0063 0.1264 0.1603
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0101 0.2257 0.2863
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0034 0.0043
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0106 0.0134
Giardia lamblia PHD finger protein 15 0.0026 0.0304 0.0476
Onchocerca volvulus 0.0043 0.0747 0.0716
Schistosoma mansoni tar DNA-binding protein 0.006 0.1203 0.1526
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0017 0.0066 0.0102
Schistosoma mansoni DNA helicase recq5 0.0018 0.0096 0.0122
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0026 0.0288 0.0452
Treponema pallidum phosphoglycerate kinase 0.0153 0.3646 1
Entamoeba histolytica hexokinase 2 0.0148 0.35 0.5462
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0433 0.1097
Brugia malayi polk-prov protein 0.0054 0.1032 0.1032
Echinococcus multilocularis hexokinase 0.0148 0.35 0.444
Echinococcus multilocularis Peptidase C54 0.0053 0.101 0.1282
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0035 0.0538 0.0506
Leishmania major hexokinase, putative 0.0148 0.35 0.5502
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0034 0.0516 0.0654
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0059 0.1173 0.1489
Trichomonas vaginalis cdc25c, putative 0.0043 0.0747 0.1174
Brugia malayi hypothetical protein 0.0017 0.0066 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.2856 0.4489
Brugia malayi Bromodomain containing protein 0.0026 0.0304 0.0304
Brugia malayi Rhodanese-like domain containing protein 0.0043 0.0747 0.0747
Brugia malayi photoreceptor-specific nuclear receptor 0.0244 0.6032 0.6032
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.008 0.1713 0.4696
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0106 0.0106
Echinococcus multilocularis cysteine protease atg4b 0.0053 0.101 0.1282
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0096 0.0242
Loa Loa (eye worm) hypothetical protein 0.0153 0.3646 0.3646
Echinococcus granulosus regulator of G protein signaling 7 0.0016 0.0034 0.0043
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0017 0.0057 0.0073
Leishmania major DNA polymerase eta, putative 0.017 0.4074 0.6404
Trypanosoma brucei hexokinase 0.0148 0.35 0.5502
Echinococcus granulosus chromobox protein 1 0.0063 0.1264 0.1603
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0153 0.3646 0.5732
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.0784 0.0784
Brugia malayi RNA recognition motif domain containing protein 0.006 0.1203 0.1203
Schistosoma mansoni hypothetical protein 0.0035 0.0524 0.0664
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0087 0.19 0.5209
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0106 0.0134
Brugia malayi intracellular kinase 0.0042 0.0729 0.0729
Echinococcus granulosus segment polarity protein dishevelled 0.0016 0.0034 0.0043
Brugia malayi steroid hormone receptor 0.0019 0.0106 0.0106
Echinococcus granulosus dna polymerase eta 0.017 0.4074 0.5168
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.2856 0.4489
Trypanosoma brucei chrX additional, unordered contigs 0.0031 0.0433 0.068
Loa Loa (eye worm) heterochromatin protein 1 0.0063 0.1264 0.1264
Onchocerca volvulus 0.0043 0.0747 0.0716
Schistosoma mansoni DNA helicase recq1 0.0018 0.0096 0.0122
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.008 0.1713 0.4696
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0106 0.0134
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0153 0.3646 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0106 0.0134
Trypanosoma brucei phosphoglycerate kinase 0.0153 0.3646 0.5732
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0106 0.0106
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0101 0.2257 0.2863
Leishmania major phosphoglycerate kinase B, cytosolic 0.0153 0.3646 0.5732
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0096 0.015
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0034 0.0043
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.008 0.1713 0.2173
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0009 0.0013
Schistosoma mansoni SET domain protein 0.0019 0.0118 0.015
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.1039 0.1039
Brugia malayi serine/threonine-protein kinase plk-2 0.0257 0.6361 0.6361
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0106 0.0134
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0053 0.101 0.1587
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0153 0.3646 0.5732
Schistosoma mansoni hepatoma derived growth factor 0.0017 0.0066 0.0084
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0053 0.101 0.1282
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0096 0.0096
Echinococcus granulosus disco interacting protein 2 0.0033 0.048 0.0609
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0106 0.0134
Trypanosoma brucei polo-like protein kinase 0.0257 0.6361 1
Echinococcus multilocularis PWWP domain containing protein 2A 0.0017 0.0066 0.0084
Loa Loa (eye worm) hexokinase 0.0148 0.35 0.35
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.2454 0.1931
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0043 0.0747 0.1174
Echinococcus multilocularis peregrin 0.0044 0.0757 0.096
Chlamydia trachomatis phosphoglycerate kinase 0.0153 0.3646 1
Trypanosoma brucei hexokinase, putative 0.0148 0.35 0.5502
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0009 0.0013
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0017 0.0066 0.0102
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0017 0.0057 0.0089
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0087 0.19 0.2986
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0733 0.093
Leishmania major DNA polymerase kappa, putative 0.0106 0.2406 0.3781
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.1585 0.2491
Schistosoma mansoni hypothetical protein 0.0026 0.0304 0.0385
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.1032 0.1622
Schistosoma mansoni tar DNA-binding protein 0.006 0.1203 0.1526
Entamoeba histolytica serine/threonine protein kinase, putative 0.0257 0.6361 1
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0153 0.3646 1
Trypanosoma brucei protein kinase, putative 0.0042 0.0729 0.1145
Schistosoma mansoni hepatoma derived growth factor 0.0017 0.0066 0.0084
Schistosoma mansoni hypothetical protein 0.002 0.0151 0.0192
Entamoeba histolytica peptidase, C54 family 0.0021 0.0158 0.0159
Onchocerca volvulus 0.0148 0.35 0.3478
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.004 0.0659 0.0659
Loa Loa (eye worm) hexokinase type II 0.0148 0.35 0.35
Echinococcus granulosus tar DNA binding protein 0.006 0.1203 0.1526
Schistosoma mansoni hypothetical protein 0.0017 0.0066 0.0084
Loa Loa (eye worm) PWWP domain-containing protein 0.0017 0.0066 0.0066
Giardia lamblia Kinase, PLK 0.0257 0.6361 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0009 0.0013
Toxoplasma gondii hexokinase 0.0148 0.35 0.8881
Echinococcus multilocularis hexokinase 0.0148 0.35 0.444
Loa Loa (eye worm) RNA binding protein 0.006 0.1203 0.1203
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0167 0.4005 0.4005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0106 0.0106
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0106 0.0134
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.2454 0.673
Trypanosoma brucei DNA damage repair protein, putative 0.0031 0.0433 0.068
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0106 0.0106
Giardia lamblia Phosphoglycerate kinase 0.0153 0.3646 0.5732
Echinococcus multilocularis regulator of G protein signaling 7 0.0016 0.0034 0.0043
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0009 0.0009
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0042 0.0729 0.0925
Trypanosoma brucei phosphoglycerate kinase 0.0056 0.1093 0.1718
Entamoeba histolytica phosphoglycerate kinase, putative 0.0153 0.3646 0.5694
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0053 0.101 0.1587
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0733 0.0733
Trypanosoma cruzi DNA polymerase kappa, putative 0.0123 0.2856 0.4489
Plasmodium falciparum phosphoglycerate kinase 0.0153 0.3646 1
Brugia malayi jmjC domain containing protein 0.0032 0.0449 0.0449
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0106 0.0134
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0257 0.6361 0.8069
Brugia malayi TAR-binding protein 0.006 0.1203 0.1203
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.2169 0.5947
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0106 0.0134
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0239 0.0374
Echinococcus multilocularis dna polymerase eta 0.017 0.4074 0.5168
Echinococcus multilocularis phosphoglycerate kinase 1 0.0153 0.3646 0.4625
Echinococcus granulosus hexokinase type 2 0.0148 0.35 0.444
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0087 0.19 0.2986
Plasmodium vivax ataxin-2 like protein, putative 0.0046 0.0813 0.2228
Onchocerca volvulus 0.0148 0.35 0.3478
Plasmodium falciparum hexokinase 0.0148 0.35 0.9599
Echinococcus multilocularis tar DNA binding protein 0.006 0.1203 0.1526
Loa Loa (eye worm) hypothetical protein 0.0019 0.0106 0.0106
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0043 0.0747 0.0948
Brugia malayi MH2 domain containing protein 0.0216 0.5299 0.5299
Schistosoma mansoni cpg binding protein 0.0029 0.0367 0.0466
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0106 0.0134
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0239 0.0287
Echinococcus multilocularis geminin 0.0314 0.7883 1
Entamoeba histolytica peptidase, C54 family 0.0021 0.0158 0.0159
Schistosoma mansoni tar DNA-binding protein 0.006 0.1203 0.1526
Trichomonas vaginalis CAMK family protein kinase 0.0257 0.6361 1
Trichomonas vaginalis CAMK family protein kinase 0.0257 0.6361 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.2856 0.4489
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.006 0.1203 0.1203
Brugia malayi glucose-6-phosphate dehydrogenase 0.008 0.1713 0.1713
Echinococcus multilocularis dna polymerase kappa 0.0123 0.2856 0.3623
Echinococcus granulosus bloom syndrome protein 0.0045 0.0784 0.0995
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.017 0.4071 0.4071
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0733 0.2009
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0106 0.0106
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0257 0.6361 0.8069
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.2454 0.673
Loa Loa (eye worm) hypothetical protein 0.0051 0.0945 0.0945
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0026 0.0304 0.0385
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0017 0.0057 0.0143
Loa Loa (eye worm) hypothetical protein 0.0325 0.8169 0.8169
Onchocerca volvulus 0.0017 0.0066 0.0032
Plasmodium vivax glutathione reductase, putative 0.0043 0.0733 0.2009
Plasmodium vivax hexokinase, putative 0.0148 0.35 0.9599
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0106 0.0134
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0001 0.0001
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0043 0.0747 0.1174
Trichomonas vaginalis cdc25b, putative 0.0043 0.0747 0.1174
Mycobacterium ulcerans phosphoglycerate kinase 0.0153 0.3646 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0106 0.0106
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.008 0.1713 0.2173
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0087 0.19 0.2986
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0096 0.0122
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0239 0.0374
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.2169 0.5947
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0106 0.0134
Onchocerca volvulus 0.0043 0.0747 0.0716
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0066 0.0102
Loa Loa (eye worm) MH2 domain-containing protein 0.0216 0.5299 0.5299
Trypanosoma cruzi PAB1-binding protein , putative 0.0046 0.0813 0.1277
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0009 0.0012
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0945 0.0945
Echinococcus multilocularis hexokinase 0.0148 0.35 0.444
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0239 0.0374
Giardia lamblia DNA damage repair protein 0.0031 0.0433 0.068
Loa Loa (eye worm) pax transcription factor protein 2 0.023 0.5655 0.5655
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0053 0.101 0.1587
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0367 0.0367
Schistosoma mansoni tar DNA-binding protein 0.006 0.1203 0.1526
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0106 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.2856 0.4489
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0257 0.6361 1
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0433 0.068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0123 0.2856 0.4489
Brugia malayi Heterochromatin protein 1 0.0063 0.1264 0.1264
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.2169 0.5947
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0106 0.0106
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0608 0.0955
Echinococcus granulosus lysine specific demethylase 5A 0.0032 0.0449 0.0569
Loa Loa (eye worm) hypothetical protein 0.0053 0.101 0.101
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0106 0.0106
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0001 0.0001
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0106 0.0072
Schistosoma mansoni transcription factor LCR-F1 0.0034 0.0516 0.0654
Echinococcus multilocularis regulator of G protein signaling 7 0.0016 0.0034 0.0043
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0153 0.3646 0.5732
Schistosoma mansoni jumonji domain containing protein 0.0068 0.141 0.1789
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0056 0.1093 0.1718
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0009 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.2856 0.4489
Brugia malayi Phosphoglycerate kinase 0.0153 0.3646 0.3646
Loa Loa (eye worm) glutathione reductase 0.0043 0.0733 0.0733
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0009 0.0023
Schistosoma mansoni cpg binding protein 0.0029 0.0367 0.0466
Loa Loa (eye worm) hypothetical protein 0.0019 0.0106 0.0106
Trypanosoma cruzi hexokinase, putative 0.0148 0.35 0.5502
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0268 0.042
Schistosoma mansoni phosphoglycerate kinase 0.0153 0.3646 0.4625
Onchocerca volvulus 0.023 0.5655 0.564
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0433 0.068
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0106 0.0106
Trichomonas vaginalis cdc25b, putative 0.0043 0.0747 0.1174
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0106 0.0134
Schistosoma mansoni autophagin-1 (C54 family) 0.0053 0.101 0.1282
Onchocerca volvulus 0.0029 0.0367 0.0335
Treponema pallidum hexokinase (hxk) 0.0148 0.35 0.9599
Entamoeba histolytica hypothetical protein 0.0034 0.0516 0.0727
Brugia malayi N-terminal motif family protein 0.0325 0.8169 0.8169
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0009 0.0021
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0042 0.0729 0.1848
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0106 0.0134
Echinococcus multilocularis hepatoma derived growth factor protein 0.0017 0.0066 0.0084
Loa Loa (eye worm) hypothetical protein 0.0043 0.0747 0.0747
Schistosoma mansoni chromobox protein 0.0063 0.1264 0.1603
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0106 0.0134
Loa Loa (eye worm) RecQ helicase 0.0045 0.0784 0.0784
Schistosoma mansoni kinase 0.0131 0.3047 0.3866
Brugia malayi Rhodanese-like domain containing protein 0.0043 0.0747 0.0747
Schistosoma mansoni jumonji/arid domain-containing protein 0.0032 0.0449 0.0569
Trichomonas vaginalis chromobox protein, putative 0.0063 0.1264 0.1986
Schistosoma mansoni phosphoglycerate kinase 0.0153 0.3646 0.4625
Echinococcus granulosus PHD finger protein rhinoceros 0.0026 0.0304 0.0385
Brugia malayi PHD-finger family protein 0.0026 0.0304 0.0304
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0106 0.2406 0.6597
Echinococcus multilocularis traf and tnf receptor associated protein 0.017 0.4071 0.5165
Echinococcus granulosus protein kinase shaggy 0.0042 0.0729 0.0925
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0106 0.0134
Trichomonas vaginalis chromobox protein, putative 0.0063 0.1264 0.1986
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0096 0.0096
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0106 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.1585 0.2491
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0733 0.093
Mycobacterium ulcerans DNA polymerase IV 0.0123 0.2856 0.7832
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0037 0.0582 0.1474
Trichomonas vaginalis CAMK family protein kinase 0.0257 0.6361 1
Trypanosoma cruzi hexokinase, putative 0.0148 0.35 0.5502
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0123 0.2856 0.4489
Entamoeba histolytica hypothetical protein 0.0017 0.0066 0.0013
Schistosoma mansoni DNA polymerase IV / kappa 0.0031 0.0433 0.055
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0106 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0268 0.042
Loa Loa (eye worm) PHD-finger family protein 0.0026 0.0304 0.0304
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.008 0.1713 0.2692
Trypanosoma brucei trypanothione reductase 0.0043 0.0733 0.1151
Trypanosoma brucei DNA damage repair protein, putative 0.0031 0.0433 0.068
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0405 0.1108
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0034 0.0516 0.0654
Plasmodium falciparum cysteine protease ATG4, putative 0.0021 0.0158 0.043
Loa Loa (eye worm) hypothetical protein 0.0047 0.0849 0.0849
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0538 0.0845
Leishmania major DNA polymerase eta, putative 0.01 0.225 0.3537
Trichomonas vaginalis CAMK family protein kinase 0.0257 0.6361 1
Echinococcus multilocularis disco interacting protein 2 0.0033 0.048 0.0609
Echinococcus multilocularis cpg binding protein 0.0029 0.0367 0.0466
Leishmania major phosphoglycerate kinase C, glycosomal 0.0153 0.3646 0.5732
Brugia malayi hypothetical protein 0.0016 0.0034 0.0034
Echinococcus granulosus hexokinase 0.0148 0.35 0.444
Schistosoma mansoni tar DNA-binding protein 0.006 0.1203 0.1526
Brugia malayi hypothetical protein 0.0029 0.0388 0.0388
Schistosoma mansoni hypothetical protein 0.0017 0.0066 0.0084
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0101 0.2257 0.2863
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0433 0.068
Echinococcus granulosus segment polarity protein dishevelled 0.0016 0.0034 0.0043
Onchocerca volvulus 0.0395 1 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0016 0.0034 0.0034
Brugia malayi Phosphoglycerate kinase 0.0056 0.1093 0.1093
Loa Loa (eye worm) hypothetical protein 0.0043 0.0747 0.0747
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0034 0.0034
Entamoeba histolytica protein kinase domain containing protein 0.0042 0.0729 0.1065
Loa Loa (eye worm) hypothetical protein 0.0395 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0106 0.0106
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0017 0.0057 0.0073
Echinococcus granulosus Peptidase C54 0.0053 0.101 0.1282
Toxoplasma gondii PHD-finger domain-containing protein 0.0026 0.0304 0.0768
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0086 0.1876 0.2379
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0106 0.0106
Plasmodium falciparum DNA repair protein REV1, putative 0.0031 0.0433 0.1186
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0101 0.2257 0.2257
Brugia malayi Peptidase family C54 containing protein 0.0053 0.101 0.101
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0042 0.0729 0.0729
Brugia malayi hexokinase type II 0.0047 0.0849 0.0849
Trypanosoma brucei DNA polymerase kappa, putative 0.0106 0.2406 0.3781
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0016 0.0034 0.0034
Schistosoma mansoni terminal deoxycytidyl transferase 0.0101 0.2257 0.2863
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0257 0.6361 0.6361
Brugia malayi hypothetical protein 0.0016 0.0034 0.0034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0106 0.0134
Trypanosoma brucei DNA polymerase IV, putative 0.0123 0.2856 0.4489
Onchocerca volvulus Serine\/threonine kinase homolog 0.0257 0.6361 0.6348
Entamoeba histolytica protein kinase, putative 0.0042 0.0729 0.1065
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0106 0.0106
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0056 0.1093 0.1718
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0106 0.0134
Toxoplasma gondii DNA methyltransferase 2, putative 0.0017 0.0057 0.0143
Leishmania major DNA polymerase kappa, putative 0.0031 0.0433 0.068
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.2856 0.4489
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.0784 0.1232
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0538 0.0682
Brugia malayi hypothetical protein 0.0046 0.0813 0.0813
Echinococcus granulosus hepatoma derived growth factor protein 0.0017 0.0066 0.0084
Schistosoma mansoni SET domain protein 0.0059 0.1173 0.1489
Toxoplasma gondii hypothetical protein 0.0017 0.0066 0.0165
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0106 0.0134
Plasmodium vivax phosphoglycerate kinase, putative 0.0153 0.3646 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0733 0.2009
Echinococcus multilocularis jumonji domain containing protein 0.0037 0.0574 0.0728
Trypanosoma cruzi PAB1-binding protein , putative 0.0046 0.0813 0.1277
Brugia malayi ImpB/MucB/SamB family protein 0.017 0.4074 0.4074
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0072 0.1518 0.4163
Schistosoma mansoni hexokinase 0.0148 0.35 0.444
Trypanosoma brucei phosphoglycerate kinase 0.0153 0.3646 0.5732
Trypanosoma brucei DNA polymerase eta, putative 0.017 0.4074 0.6404
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0009 0.0012
Trypanosoma brucei hexokinase 0.0148 0.35 0.5502
Echinococcus granulosus phosphoglycerate kinase 1 0.0153 0.3646 0.4625
Loa Loa (eye worm) hexokinase 0.0093 0.2051 0.2051
Leishmania major hexokinase, putative 0.0148 0.35 0.5502
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0056 0.1093 0.1718
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0056 0.1093 0.1718
Trypanosoma brucei transcription elongation factor s-II, putative 0.0017 0.0066 0.0102
Toxoplasma gondii LsmAD domain-containing protein 0.0046 0.0813 0.2061
Schistosoma mansoni hypothetical protein 0.0034 0.0516 0.0654
Plasmodium falciparum ataxin-2 like protein, putative 0.0046 0.0813 0.2228
Trypanosoma brucei unspecified product 0.0118 0.2707 0.4255
Trypanosoma brucei DNA polymerase IV, putative 0.0123 0.2856 0.4489
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0059 0.1173 0.1489
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0304 0.083
Brugia malayi Pax transcription factor protein 2 0.023 0.5655 0.5655
Trichomonas vaginalis CAMK family protein kinase 0.0257 0.6361 1
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0019 0.0118 0.015
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0043
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0019 0.0118 0.015
Entamoeba histolytica hexokinase 1 0.0148 0.35 0.5462
Entamoeba histolytica peptidase, C54 family 0.0021 0.0158 0.0159
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.2454 0.673
Loa Loa (eye worm) hypothetical protein 0.0054 0.1032 0.1032
Schistosoma mansoni hypothetical protein 0.0314 0.7883 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0009 0.0012
Giardia lamblia Kinase, CMGC GSK 0.0042 0.0729 0.1145
Onchocerca volvulus 0.0043 0.0747 0.0716
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.2856 0.4489
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0153 0.3646 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0032 0.0449 0.0569
Entamoeba histolytica deoxycytidyl transferase, putative 0.0101 0.2257 0.349
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0053 0.101 0.1282
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0016 0.0034 0.0043
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0042 0.0729 0.0729
Trichomonas vaginalis CMGC family protein kinase 0.0042 0.0729 0.1145
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0087 0.19 0.2986
Toxoplasma gondii hypothetical protein 0.0072 0.1518 0.3851
Trypanosoma brucei phosphoglycerate kinase, putative 0.0056 0.1093 0.1718
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.008 0.1713 0.1713
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0096 0.0242
Brugia malayi CXXC zinc finger family protein 0.0029 0.0367 0.0367
Schistosoma mansoni hypothetical protein 0.0314 0.7883 1
Toxoplasma gondii hypothetical protein 0.0016 0.0034 0.0083
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0043 0.0747 0.0948
Echinococcus multilocularis protein kinase shaggy 0.0042 0.0729 0.0925
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.2169 0.5947
Schistosoma mansoni z-protein (S1r protein) 0.0016 0.0034 0.0043
Entamoeba histolytica peptidase, C54 family 0.0053 0.101 0.1512
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0433 0.068
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0165 0.3941 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0449 0.0449
Brugia malayi nuclear receptor NHR-88 0.0019 0.0106 0.0106
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0153 0.3646 0.5732
Schistosoma mansoni coup transcription factor 0.0019 0.0106 0.0134
Brugia malayi Disco-interacting protein 2 homolog 0.0033 0.048 0.048
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0945 0.0945
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0053 0.101 0.1587
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0034
Echinococcus multilocularis segment polarity protein dishevelled 0.0016 0.0034 0.0043
Schistosoma mansoni dishevelled 0.0016 0.0034 0.0043
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0042 0.0729 0.0925
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0009 0.0013
Brugia malayi hexokinase 0.0148 0.35 0.35
Plasmodium vivax DNA repair protein REV1, putative 0.0031 0.0433 0.1186
Brugia malayi chromobox protein homolog 3 0.0035 0.0538 0.0538
Echinococcus granulosus geminin 0.0314 0.7883 1
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0043 0.0747 0.1174
Echinococcus granulosus PWWP domain containing protein 2A 0.0017 0.0066 0.0084
Onchocerca volvulus 0.0028 0.0338 0.0306
Loa Loa (eye worm) hypothetical protein 0.0244 0.6032 0.6032
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0009 0.0021
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.2257 0.6189
Entamoeba histolytica peptidase, C54 family 0.0021 0.0158 0.0159
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0042 0.0729 0.1145
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0017 0.0057 0.0155
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0001 0.0001
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0087 0.19 0.5209
Entamoeba histolytica rodhanase-like domain containing protein 0.0043 0.0747 0.1095
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0106 0.0106
Echinococcus granulosus DNA methyltransferase 2, putative 0.0017 0.0057 0.0073
Trypanosoma cruzi polo-like protein kinase, putative 0.0257 0.6361 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0945 0.0945
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.008 0.1713 0.2173
Loa Loa (eye worm) hypothetical protein 0.0045 0.0797 0.0797
Trichomonas vaginalis CAMK family protein kinase 0.0127 0.2958 0.465
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0106 0.0106
Toxoplasma gondii thioredoxin reductase 0.0043 0.0733 0.1859
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0239 0.0374
Brugia malayi RNA binding protein 0.006 0.1203 0.1203
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0033 0.048 0.0609
Trichomonas vaginalis CAMK family protein kinase 0.0127 0.2958 0.465
Onchocerca volvulus 0.0033 0.048 0.0448
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.008 0.1713 0.2692
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0053 0.101 0.1587
Toxoplasma gondii ImpB/MucB/SamB family protein 0.01 0.225 0.5709
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0066 0.0102
Loa Loa (eye worm) hypothetical protein 0.0019 0.0106 0.0106
Mycobacterium ulcerans DNA polymerase IV 0.0123 0.2856 0.7832
Onchocerca volvulus 0.0019 0.0106 0.0072
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0052 0.0984 0.2496
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0043 0.0747 0.0948
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0017 0.0057 0.0155
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0053 0.101 0.1587
Loa Loa (eye worm) hypothetical protein 0.004 0.0659 0.0659
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0106 0.0106
Loa Loa (eye worm) transcription factor SMAD2 0.0216 0.5299 0.5299
Leishmania major hypothetical protein, conserved 0.0046 0.0813 0.1277
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0106 0.0134
Trypanosoma brucei unspecified product 0.0069 0.1436 0.2257
Echinococcus granulosus peregrin 0.0044 0.0757 0.096
Loa Loa (eye worm) hypothetical protein 0.0101 0.2264 0.2264
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0043
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0056 0.1093 0.1718
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0009 0.0009
Echinococcus granulosus PWWP domain containing protein 2A 0.0017 0.0066 0.0084
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0524 0.0524
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0009 0.0013
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0021 0.0158 0.0246
Schistosoma mansoni phd finger protein 0.0017 0.0066 0.0084
Leishmania major trypanothione reductase 0.0043 0.0733 0.1151
Loa Loa (eye worm) hexokinase 0.0148 0.35 0.35
Trichomonas vaginalis CAMK family protein kinase 0.0257 0.6361 1
Trypanosoma cruzi DNA polymerase eta, putative 0.017 0.4074 0.6404
Brugia malayi Hexokinase family protein 0.0148 0.35 0.35
Leishmania major DNA damage repair protein, putative 0.0031 0.0433 0.068
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0325 0.8169 0.8163
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0021 0.0158 0.0398
Loa Loa (eye worm) hypothetical protein 0.0026 0.0304 0.0304
Mycobacterium tuberculosis Probable reductase 0.0097 0.2169 0.5947
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.2856 0.4489
Loa Loa (eye worm) hypothetical protein 0.017 0.4074 0.4074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0106 0.0106
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0106 0.0134
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0096 0.0261
Plasmodium falciparum glycogen synthase kinase 3 0.0042 0.0729 0.1997
Onchocerca volvulus 0.0148 0.35 0.3478
Loa Loa (eye worm) hypothetical protein 0.0046 0.0813 0.0813
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0106 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.1585 0.2491
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0043
Echinococcus granulosus regulator of G protein signaling 7 0.0016 0.0034 0.0043
Brugia malayi Hexokinase family protein 0.0093 0.2051 0.2051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0538 0.0538
Trichomonas vaginalis DNA polymerase eta, putative 0.0123 0.2856 0.4489
Brugia malayi nuclear hormone receptor 0.0019 0.0106 0.0106
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.002 0.0151 0.0192
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0106 0.0134
Brugia malayi Thioredoxin reductase 0.0043 0.0733 0.0733
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0053 0.101 0.1587
Schistosoma mansoni dishevelled 0.0016 0.0034 0.0043
Plasmodium vivax glycogen synthase kinase 3, putative 0.0042 0.0729 0.1997
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0395 0.1001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0034 0.0043
Entamoeba histolytica rodhanase-like domain containing protein 0.0043 0.0747 0.1095
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0034 0.0043
Echinococcus granulosus jumonji domain containing protein 0.0037 0.0574 0.0728
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0043 0.0747 0.1174
Schistosoma mansoni dep domain containing protein 0.0016 0.0034 0.0043
Entamoeba histolytica hypothetical protein 0.0034 0.0516 0.0727
Loa Loa (eye worm) DIX domain-containing protein 0.0016 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0106 0.0106
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0106 0.0134
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0733 0.1151
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0021 0.0158 0.0246
Plasmodium falciparum phd finger protein, putative 0.0026 0.0304 0.083
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0106 0.0134
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0106 0.0134
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0642 0.1758
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0106 0.0106
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0009 0.0012
Entamoeba histolytica hypothetical protein 0.0034 0.0516 0.0727
Echinococcus granulosus hexokinase 0.0148 0.35 0.444
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0066
Echinococcus granulosus Pleckstrin G protein interacting region 0.0016 0.0034 0.0043
Onchocerca volvulus 0.0093 0.2051 0.2024
Leishmania major hypothetical protein, conserved 0.0017 0.0066 0.0102
Schistosoma mansoni chromobox protein 0.0063 0.1264 0.1603
Brugia malayi isocitrate dehydrogenase 0.0015 0.0009 0.0009
Echinococcus granulosus GPCR family 2 0.0016 0.0034 0.0043
Trypanosoma brucei unspecified product 0.0069 0.1436 0.2257
Echinococcus multilocularis GPCR, family 2 0.0016 0.0034 0.0043
Onchocerca volvulus 0.0017 0.0066 0.0032
Trypanosoma cruzi polo-like protein kinase, putative 0.0257 0.6361 1
Brugia malayi glutathione reductase 0.0043 0.0733 0.0733
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.1032 0.1622
Brugia malayi jmjC domain containing protein 0.0086 0.1876 0.1876
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0538 0.0845
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0017 0.0066 0.0102
Trypanosoma brucei PAB1-binding protein , putative 0.0046 0.0813 0.1277
Brugia malayi DIX domain containing protein 0.0016 0.0034 0.0034
Giardia lamblia Kinase, CMGC GSK 0.0042 0.0729 0.1145
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0096 0.0096
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0106 0.0134
Brugia malayi regulator of G-protein signaling egl-10 0.0016 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0106 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0224 0.551 0.551
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0021 0.0158 0.0246
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0034 0.0034
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0042 0.0729 0.0925
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0009 0.0012
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.2169 0.5947
Toxoplasma gondii PHD-finger domain-containing protein 0.0026 0.0304 0.0768
Brugia malayi PWWP domain containing protein 0.0017 0.0066 0.0066
Entamoeba histolytica protein kinase domain containing protein 0.0042 0.0729 0.1065
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0096 0.0122
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0026 0.0308 0.0484
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0608 0.0577
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0043
Plasmodium falciparum thioredoxin reductase 0.0043 0.0733 0.2009
Schistosoma mansoni cpg binding protein 0.0029 0.0367 0.0466
Echinococcus multilocularis bloom syndrome protein 0.0045 0.0784 0.0995
Schistosoma mansoni DNA polymerase eta 0.017 0.4074 0.5168
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0052 0.0984 0.2697
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0106 0.0134
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0001 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0123 0.2856 0.4489
Brugia malayi hypothetical protein 0.0017 0.0066 0.0066
Echinococcus multilocularis chromobox protein 1 0.0063 0.1264 0.1603
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0028 0.0341 0.0933
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0106 0.0106
Brugia malayi hypothetical protein 0.0034 0.0516 0.0516
Echinococcus granulosus cysteine protease atg4b 0.0053 0.101 0.1282
Loa Loa (eye worm) hypothetical protein 0.0047 0.0849 0.0849
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0043 0.0747 0.1174
Brugia malayi Hexokinase family protein 0.0046 0.0815 0.0815
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.008 0.1713 0.4696
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0096 0.0122
Echinococcus granulosus cpg binding protein 0.0029 0.0367 0.0466
Loa Loa (eye worm) hypothetical protein 0.0033 0.048 0.048
Brugia malayi ecdysteroid receptor 0.0019 0.0106 0.0106
Loa Loa (eye worm) hexokinase 0.0046 0.0815 0.0815
Echinococcus multilocularis chromobox protein 1 0.0063 0.1264 0.1603
Echinococcus multilocularis PHD finger protein rhinoceros 0.0026 0.0304 0.0385
Onchocerca volvulus 0.0042 0.0729 0.0698
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0086 0.1876 0.2379
Trypanosoma cruzi DNA polymerase eta, putative 0.01 0.225 0.3537
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0096 0.0122
Onchocerca volvulus Hexokinase homolog 0.0093 0.2051 0.2024
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0106 0.2406 0.3781
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0106 0.0106
Trypanosoma brucei DNA polymerase IV, putative 0.0118 0.2707 0.4255
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0056 0.1093 0.1718
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0106 0.0072
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0106 0.0134
Plasmodium falciparum glutathione reductase 0.0043 0.0733 0.2009
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0042 0.0729 0.1145
Schistosoma mansoni serine/threonine protein kinase 0.0257 0.6361 0.8069
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0608 0.0955
Loa Loa (eye worm) TAR-binding protein 0.006 0.1203 0.1203
Plasmodium falciparum ataxin-2 like protein, putative 0.0046 0.0813 0.2228
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.2856 0.4489
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0053 0.101 0.1587
Trichomonas vaginalis CAMK family protein kinase 0.0257 0.6361 1
Echinococcus granulosus hexokinase 0.0148 0.35 0.444
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0021 0.0158 0.0246
Echinococcus granulosus dna polymerase kappa 0.0123 0.2856 0.3623
Echinococcus granulosus traf and tnf receptor associated protein 0.017 0.4071 0.5165
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0034 0.0034
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0009 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.0042 0.0729 0.1145
Entamoeba histolytica hypothetical protein 0.0034 0.0516 0.0727
Echinococcus multilocularis segment polarity protein dishevelled 0.0016 0.0034 0.0043
Loa Loa (eye worm) hypothetical protein 0.0035 0.0524 0.0524
Echinococcus multilocularis PWWP domain containing protein 2A 0.0017 0.0066 0.0084
Loa Loa (eye worm) hypothetical protein 0.0028 0.0338 0.0338
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0153 0.3646 0.9252
Schistosoma mansoni hypothetical protein 0.0017 0.0066 0.0084
Trypanosoma cruzi DNA damage repair protein, putative 0.0031 0.0433 0.068
Loa Loa (eye worm) hypothetical protein 0.0018 0.0096 0.0096
Echinococcus multilocularis lysine specific demethylase 5A 0.0032 0.0449 0.0569
Giardia lamblia DINP protein human, muc B family 0.0106 0.2406 0.3781

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.