Detailed information for compound 789326

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 491.971 | Formula: C20H18ClN5O4S2
  • H donors: 0 H acceptors: 3 LogP: 3.72 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1n1c(C)cc(c1C)/C=C\1/C(=O)N=c2n(C1=N)nc(s2)S(=O)(=O)C)Cl
  • InChi: 1S/C20H18ClN5O4S2/c1-10-7-12(11(2)25(10)15-9-13(21)5-6-16(15)30-3)8-14-17(22)26-19(23-18(14)27)31-20(24-26)32(4,28)29/h5-9,22H,1-4H3/b14-8+,22-17?
  • InChiKey: XOXRVEOTGMWZFC-FRYOISGKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0194 0.2105
Loa Loa (eye worm) hypothetical protein 0.0048 0.0105 0.0035
Schistosoma mansoni aldehyde dehydrogenase 0.0195 0.076 0.076
Brugia malayi TAR-binding protein 0.0068 0.0192 0.036
Echinococcus multilocularis caspase 3 0.0077 0.0236 0.0236
Brugia malayi Pre-SET motif family protein 0.0205 0.0805 0.1657
Leishmania major hypothetical protein, conserved 0.0076 0.0228 0.2581
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0069 0.0306
Trichomonas vaginalis glucosylceramidase, putative 0.0538 0.2287 0.6404
Loa Loa (eye worm) hypothetical protein 0.0057 0.0147 0.0078
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0195 0.076 0.9942
Loa Loa (eye worm) hypothetical protein 0.0091 0.0297 0.0229
Loa Loa (eye worm) acetyltransferase 0.0157 0.059 0.0524
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0228 0.0507
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0196 0.0765 0.3474
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0168 0.064 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0068 0.0194 0.2105
Schistosoma mansoni alpha glucosidase 0.0154 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0084 0.0263 0.0195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0196 0.1652
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0228 0.0864
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0069 0.0069
Echinococcus granulosus importin 5 0.004 0.007 0.007
Brugia malayi hypothetical protein 0.0044 0.0087 0.0136
Brugia malayi PHD-finger family protein 0.0031 0.0028 0.0013
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0228 0.0864
Echinococcus multilocularis neutral alpha glucosidase AB 0.0154 0.0577 0.0577
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0084 0.0263 0.3062
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.059 0.059
Echinococcus multilocularis geminin 0.1234 0.5382 0.5382
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0069 0.0382
Loa Loa (eye worm) hypothetical protein 0.109 0.4743 0.4706
Leishmania major alpha glucosidase II subunit, putative 0.0154 0.0577 0.7407
Trichomonas vaginalis alpha-glucosidase, putative 0.0057 0.0147 0.0273
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0078 0.0236 0.0236
Brugia malayi jmjC domain containing protein 0.0315 0.1295 0.2696
Loa Loa (eye worm) hypothetical protein 0.0168 0.064 0.0574
Schistosoma mansoni apoferritin-2 0.0036 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0101 0.0142
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0168 0.064 0.2265
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0084 0.0263 0.0884
Brugia malayi Glycosyl hydrolases family 31 protein 0.0694 0.2982 0.627
Mycobacterium ulcerans beta-lactamase 0.0076 0.0228 0.2495
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0068 0.0194 0.0697
Trichomonas vaginalis maltase-glucoamylase, putative 0.0057 0.0147 0.0273
Echinococcus multilocularis lysosomal alpha glucosidase 0.0694 0.2982 0.2982
Leishmania major cathepsin L-like protease 0.0069 0.0196 0.2139
Brugia malayi RNA binding protein 0.0068 0.0192 0.036
Schistosoma mansoni jumonji/arid domain-containing protein 0.0315 0.1295 0.1295
Onchocerca volvulus 0.0044 0.0087 0.0284
Trypanosoma brucei importin beta-1 subunit, putative 0.0213 0.0838 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0228 0.016
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0484 0.2045 0.9702
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0168 0.064 0.7415
Loa Loa (eye worm) hypothetical protein 0.0127 0.0457 0.039
Trichomonas vaginalis hypothetical protein 0.004 0.007 0.0054
Plasmodium vivax importin-beta 2, putative 0.0213 0.0838 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0497 0.2106 1
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.0105 0.0469
Schistosoma mansoni jumonji/arid domain-containing protein 0.0315 0.1295 0.1295
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0078 0.0236 0.0236
Trypanosoma brucei metacaspase 0.0047 0.0101 0.0412
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.0361 0.378
Trichomonas vaginalis glucosylceramidase, putative 0.0538 0.2287 0.6404
Mycobacterium tuberculosis Conserved protein 0.0076 0.0228 0.0864
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.1234 0.5382 0.5382
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0058 0.0149 0.1555
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0017 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0105 0.0105
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0057 0.0147 0.1311
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0497 0.2106 1
Echinococcus granulosus apoptotic protease activating factor 1 0.0044 0.0087 0.0087
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0068 0.0194 0.201
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0228 0.0864
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0069 0.0052
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0068 0.0194 0.201
Loa Loa (eye worm) jmjC domain-containing protein 0.0084 0.0263 0.0195
Trypanosoma brucei trypanothione reductase 0.0196 0.0765 0.9043
Brugia malayi Glycosyl hydrolases family 31 protein 0.0057 0.0147 0.0264
Schistosoma mansoni ran 0.0134 0.0486 0.0486
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0086 0.0272 0.0272
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0077 0.0122
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0448 0.1883 0.8918
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0068 0.0194 0.2105
Echinococcus granulosus JmjC domain containing protein 4 0.0084 0.0263 0.0263
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.059 0.1203
Loa Loa (eye worm) hypothetical protein 0.0105 0.0361 0.0293
Brugia malayi Bromodomain containing protein 0.0085 0.027 0.0524
Trichomonas vaginalis alpha-glucosidase, putative 0.0057 0.0147 0.0273
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.0101 0.0289
Mycobacterium tuberculosis Probable dehydrogenase 0.0448 0.1883 0.8918
Trichomonas vaginalis glucosylceramidase, putative 0.082 0.3543 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1678 0.736 0.736
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0195 0.076 0.076
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0069 0.0069
Toxoplasma gondii melibiase subfamily protein 0.0642 0.2748 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0101 0.0142
Plasmodium falciparum glutathione reductase 0.0068 0.0194 0.1609
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0428 0.1797 0.1797
Schistosoma mansoni caspase-3 (C14 family) 0.0125 0.0446 0.0446
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0078 0.0236 0.0904
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0168 0.064 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0228 0.0436
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0101 0.0142
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0036 0.0051 0.0003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0068 0.0194 0.2105
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0168 0.064 0.8297
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0065 0.0065
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.011 0.0382 0.1611
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0228 0.0228
Echinococcus granulosus caspase 2 0.0091 0.0297 0.0297
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0078 0.0236 0.2694
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0642 0.2748 0.2748
Schistosoma mansoni hypothetical protein 0.1234 0.5382 0.5382
Leishmania major cathepsin L-like protease 0.0069 0.0196 0.2139
Plasmodium falciparum glutathione reductase 0.0196 0.0765 0.9042
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0134 0.0486 0.5417
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0101 0.0142
Schistosoma mansoni importin beta-1 0.0213 0.0838 0.0838
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.011 0.0382 0.1611
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0084 0.0263 0.0884
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0068 0.0194 0.2105
Schistosoma mansoni inositol monophosphatase 0.004 0.0069 0.0069
Leishmania major metacaspase, putative 0.0047 0.0101 0.0821
Trypanosoma brucei glycosyl hydrolase-like protein 0.0057 0.0147 0.1006
Brugia malayi beta-lactamase 0.0076 0.0228 0.0436
Plasmodium falciparum metacaspase 1 0.0047 0.0101 0.04
Plasmodium falciparum thioredoxin reductase 0.0196 0.0765 0.9042
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0068 0.0194 0.0194
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0089 0.029 0.3733
Schistosoma mansoni hypothetical protein 0.0047 0.0102 0.0102
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0105 0.0153
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0134 0.0486 0.0982
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.0101 0.0289
Echinococcus granulosus jumonji domain containing 1A 0.0084 0.0263 0.0263
Trypanosoma brucei PAB1-binding protein , putative 0.0105 0.0361 0.3788
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0192 0.036
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0068 0.0194 0.2104
Loa Loa (eye worm) hypothetical protein 0.0048 0.0105 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0228 0.0507
Loa Loa (eye worm) jmjC domain-containing protein 0.0084 0.0263 0.0195
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0057 0.0147 0.0273
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0101 0.0142
Loa Loa (eye worm) kap beta 3 protein 0.004 0.007 0.0001
Echinococcus granulosus caspase 0.0125 0.0446 0.0446
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0134 0.0486 1
Echinococcus multilocularis snurportin 1 0.2271 1 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0228 0.016
Onchocerca volvulus Huntingtin homolog 0.0127 0.0457 0.192
Leishmania major GTP-binding protein, putative 0.0134 0.0486 0.6143
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0228 0.2067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0196 0.1652
Brugia malayi glutathione reductase 0.0196 0.0765 0.1572
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0125 0.0446 0.0446
Schistosoma mansoni ran 0.0134 0.0486 0.0486
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0068 0.0194 0.063
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0134 0.0486 0.5411
Trypanosoma brucei importin beta-1 subunit, putative 0.0213 0.0838 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0145 0.0076
Echinococcus granulosus geminin 0.1234 0.5382 0.5382
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0196 0.0196
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0228 0.0507
Brugia malayi Glycosyl hydrolases family 31 protein 0.0154 0.0577 0.1175
Trichomonas vaginalis mercuric reductase, putative 0.0068 0.0194 0.0408
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0101 0.0142
Loa Loa (eye worm) hypothetical protein 0.0042 0.0076 0.0007
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0931 0.2519
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0022 0.0022
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0154 0.0577 0.0511
Loa Loa (eye worm) hypothetical protein 0.0127 0.0457 0.039
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0105 0.0153
Brugia malayi hypothetical protein 0.0105 0.0361 0.0717
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0084 0.0263 0.252
Plasmodium vivax thioredoxin reductase, putative 0.0196 0.0765 0.9098
Trichomonas vaginalis glucosylceramidase, putative 0.0567 0.2416 0.6773
Echinococcus granulosus transportin 1 0.004 0.007 0.007
Schistosoma mansoni ferritin 0.0036 0.0051 0.0051
Echinococcus granulosus thioredoxin glutathione reductase 0.0196 0.0765 0.0765
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0105 0.0105
Trichomonas vaginalis glucosylceramidase, putative 0.082 0.3543 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0528 0.0528
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0528 0.0528
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0448 0.1883 0.8918
Trypanosoma cruzi metacaspase 5, putative 0.0047 0.0101 0.0821
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0528 0.0528
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0642 0.2748 0.2748
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0228 0.0507
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0125 0.0446 0.0446
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0196 0.1652
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0101 0.0142
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0036 0.0051 0.0003
Toxoplasma gondii aldehyde dehydrogenase 0.0195 0.076 0.2708
Plasmodium vivax transportin, putative 0.004 0.007 0.0589
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0057 0.0147 0.0273
Loa Loa (eye worm) hypothetical protein 0.0076 0.0228 0.016
Trichomonas vaginalis glucosylceramidase, putative 0.0538 0.2287 0.6404
Trichomonas vaginalis maltase-glucoamylase, putative 0.0154 0.0577 0.1506
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0105 0.0105
Trypanosoma brucei metacaspase 5, putative 0.0047 0.0101 0.0412
Echinococcus multilocularis apoptotic protease activating factor 1 0.0044 0.0087 0.0087
Trichomonas vaginalis alpha-glucosidase, putative 0.0057 0.0147 0.0273
Echinococcus multilocularis jumonji domain containing 1A 0.0084 0.0263 0.0263
Echinococcus multilocularis transportin 1 0.004 0.007 0.007
Brugia malayi Melibiase family protein 0.0428 0.1797 0.3758
Echinococcus multilocularis ferritin 0.0036 0.0051 0.0051
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0168 0.064 0.2866
Echinococcus multilocularis peptidase Clp (S14 family) 0.011 0.0382 0.0382
Mycobacterium tuberculosis Conserved protein 0.0076 0.0228 0.0864
Echinococcus multilocularis muscleblind protein 0.109 0.4743 0.4743
Leishmania major hypothetical protein, conserved 0.0084 0.0263 0.3062
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0084 0.0263 0.0195
Echinococcus multilocularis importin 5 0.004 0.007 0.007
Schistosoma mansoni ferritin 0.0036 0.0051 0.0051
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.0361 0.4411
Echinococcus granulosus GTP binding nuclear protein Ran 0.0134 0.0486 0.0486
Mycobacterium tuberculosis Probable oxidoreductase 0.0497 0.2106 1
Schistosoma mansoni DNA polymerase eta 0.0048 0.0105 0.0105
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.005 0.0114 0.0193
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0528 0.0528
Trichomonas vaginalis glucosylceramidase, putative 0.0567 0.2416 0.6773
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0528 0.0528
Echinococcus multilocularis thioredoxin glutathione reductase 0.0196 0.0765 0.0765
Schistosoma mansoni alpha-glucosidase 0.0598 0.2552 0.2552
Trypanosoma cruzi metacaspase, putative 0.0047 0.0101 0.0821
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0068 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0077 0.0232 0.0164
Trichomonas vaginalis alpha-glucosidase, putative 0.0154 0.0577 0.1506
Schistosoma mansoni protein phosphatase 2C 0.0084 0.0263 0.0263
Echinococcus granulosus dna polymerase eta 0.0048 0.0105 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0192 0.0192
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0228 0.2581
Onchocerca volvulus 0.0076 0.0228 0.091
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0228 0.0228
Trypanosoma cruzi metacaspase 5, putative 0.0047 0.0101 0.0821
Toxoplasma gondii LsmAD domain-containing protein 0.0105 0.0361 0.1241
Echinococcus granulosus caspase 3 0.0077 0.0236 0.0236
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0694 0.2982 0.2933
Trypanosoma brucei metacaspase MCA2 0.0047 0.0101 0.0412
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0194 0.2105
Echinococcus granulosus lysine specific demethylase 6a 0.0084 0.0263 0.0263
Trichomonas vaginalis alpha-glucosidase, putative 0.0154 0.0577 0.1506
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0154 0.0577 0.1506
Onchocerca volvulus 0.0234 0.0931 0.4011
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0078 0.0236 0.0454
Trichomonas vaginalis glucosylceramidase, putative 0.0538 0.2287 0.6404
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0068 0.0194 0.2422
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0134 0.0486 0.5682
Loa Loa (eye worm) glutathione reductase 0.0196 0.0765 0.07
Brugia malayi Bromodomain containing protein 0.0045 0.0093 0.0149
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0078 0.0236 0.0236
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0196 0.2139
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0192 0.0192
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0228 0.0864
Treponema pallidum NADH oxidase 0.0068 0.0194 0.2422
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0101 0.0142
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0105 0.0105
Toxoplasma gondii Alpha-galactosidase 0.0091 0.0296 0.1003
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0036 0.0051 0.0003
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0313 0.1286 0.1286
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0058 0.0149 0.1026
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0084 0.0263 0.0263
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0154 0.0577 0.861
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0192 0.0192
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0194 0.2105
Echinococcus multilocularis JmjC domain containing protein 4 0.0084 0.0263 0.0263
Schistosoma mansoni ferritin 0.0036 0.0051 0.0051
Trichomonas vaginalis alpha-glucosidase, putative 0.0154 0.0577 0.1506
Loa Loa (eye worm) hypothetical protein 0.0044 0.0087 0.0017
Schistosoma mansoni inositol monophosphatase 0.004 0.0069 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0196 0.1652
Plasmodium vivax glutathione reductase, putative 0.0196 0.0765 0.9098
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0068 0.0194 0.2105
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0195 0.076 0.076
Loa Loa (eye worm) hypothetical protein 0.0213 0.0838 0.0774
Leishmania major cathepsin L-like protease 0.0069 0.0196 0.2139
Echinococcus multilocularis lysine specific demethylase 5A 0.0313 0.1286 0.1286
Echinococcus granulosus peptidase Clp S14 family 0.011 0.0382 0.0382
Echinococcus multilocularis caspase 0.0125 0.0446 0.0446
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0196 0.1652
Schistosoma mansoni ferritin 0.0036 0.0051 0.0051
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0069 0.0382
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0642 0.2748 0.2748
Leishmania major importin beta-1 subunit, putative 0.0172 0.0659 0.854
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0428 0.1797 0.4998
Trichomonas vaginalis ran, putative 0.0134 0.0486 0.1244
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0228 0.2495
Brugia malayi beta-lactamase family protein 0.0076 0.0228 0.0436
Echinococcus multilocularis zinc finger protein 0.0025 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.0105 0.0361 0.4411
Trypanosoma cruzi metacaspase, putative 0.0047 0.0101 0.0821
Mycobacterium leprae Probable lipase LipE 0.0076 0.0228 0.0864
Loa Loa (eye worm) hypothetical protein 0.0076 0.0228 0.016
Echinococcus multilocularis lysine specific demethylase 6a 0.0084 0.0263 0.0263
Toxoplasma gondii hypothetical protein 0.0058 0.0149 0.0465
Echinococcus multilocularis phd:f box containing protein 0.0084 0.0263 0.0263
Schistosoma mansoni jumonji domain containing protein 0.0313 0.1286 0.1286
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0077 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0101 0.0142
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0057 0.0147 0.1452
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0228 0.2495
Trypanosoma cruzi trypanothione reductase, putative 0.0068 0.0194 0.2105
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0168 0.064 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0194 0.2105
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0448 0.1883 0.8918
Leishmania major glycosyl hydrolase-like protein 0.0057 0.0147 0.1452
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0196 0.1652
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0196 0.2139
Loa Loa (eye worm) hypothetical protein 0.0076 0.0228 0.016
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0057 0.0147 0.0549
Schistosoma mansoni bromodomain containing protein 0.0072 0.0213 0.0213
Schistosoma mansoni jumonji domain containing protein 0.0084 0.0263 0.0263
Trichomonas vaginalis glucosylceramidase, putative 0.082 0.3543 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0086 0.0272 0.0272
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0196 0.0196
Leishmania major trypanothione reductase 0.0196 0.0765 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0068 0.0194 0.2105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0196 0.1652
Echinococcus granulosus lysine specific demethylase 5A 0.0315 0.1295 0.1295
Echinococcus granulosus ferritin 0.0036 0.0051 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0196 0.1652
Echinococcus multilocularis caspase 8 0.0047 0.0101 0.0101
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0068 0.0194 0.2104
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0101 0.0142
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0168 0.064 0.7567
Trypanosoma cruzi hypothetical protein, conserved 0.0154 0.0577 0.7407
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0105 0.1012
Plasmodium vivax metacaspase 1, putative 0.0047 0.0101 0.0966
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0194 0.2105
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0078 0.0236 0.261
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0105 0.0881
Brugia malayi Thioredoxin reductase 0.0196 0.0765 0.1572
Trichomonas vaginalis alpha-glucosidase, putative 0.0057 0.0147 0.0273
Plasmodium vivax JmjC domain containing protein 0.0084 0.0263 0.2952
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0068 0.0194 0.162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0196 0.1652
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0101 0.0142
Toxoplasma gondii HEAT repeat-containing protein 0.0213 0.0838 0.2993
Mycobacterium tuberculosis Conserved protein 0.0076 0.0228 0.0864
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0228 0.0228
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0168 0.064 0.2265
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0101 0.0142
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0196 0.2139
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0642 0.2748 0.2748
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.059 0.059
Entamoeba histolytica hypothetical protein 0.0172 0.0659 1
Loa Loa (eye worm) RNA binding protein 0.0068 0.0192 0.0124
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0101 0.0142
Echinococcus multilocularis expressed protein 0.0036 0.0051 0.0051
Trichomonas vaginalis glucosylceramidase, putative 0.082 0.3543 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.005 0.0114 0.0193
Schistosoma mansoni importin-beta 2 0.004 0.007 0.007
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0228 0.0864
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0228 0.016
Plasmodium falciparum thioredoxin reductase 0.0068 0.0194 0.1609
Loa Loa (eye worm) hypothetical protein 0.0089 0.029 0.0222
Schistosoma mansoni hypothetical protein 0.0044 0.0087 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0192 0.0192
Mycobacterium tuberculosis Probable reductase 0.0448 0.1883 0.8918
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0068 0.0194 0.1609
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0448 0.1883 0.8918
Brugia malayi jmjC domain containing protein 0.0084 0.0263 0.051
Echinococcus granulosus lysosomal alpha glucosidase 0.0694 0.2982 0.2982
Onchocerca volvulus 0.0076 0.0228 0.091
Trypanosoma brucei Metacaspase-4 0.0047 0.0101 0.0412
Plasmodium falciparum JmjC domain-containing protein, putative 0.0084 0.0263 0.2511
Onchocerca volvulus Glucosylceramidase homolog 0.0538 0.2287 1
Schistosoma mansoni phd/f-box containing protein 0.0084 0.0263 0.0263
Loa Loa (eye worm) jmjC domain-containing protein 0.0315 0.1295 0.1234
Toxoplasma gondii HEAT repeat-containing protein 0.004 0.007 0.0176
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0022 0.0022
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0057 0.0147 0.1452
Brugia malayi Inositol-1 0.004 0.0069 0.01
Brugia malayi jmjC domain containing protein 0.0084 0.0263 0.051
Schistosoma mansoni phosphatidylserine receptor 0.0084 0.0263 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0196 0.1652
Toxoplasma gondii HEAT repeat-containing protein 0.004 0.007 0.0176
Trichomonas vaginalis esterase, putative 0.0076 0.0228 0.0507
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0065 0.0065
Echinococcus granulosus importin subunit beta 1 0.0213 0.0838 0.0838
Echinococcus multilocularis importin subunit beta 1 0.0213 0.0838 0.0838
Trichomonas vaginalis glucosylceramidase, putative 0.082 0.3543 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0228 0.0864
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0154 0.0577 0.1506
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0228 0.0507
Mycobacterium ulcerans lipase LipD 0.0076 0.0228 0.2495
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0078 0.0236 0.261
Onchocerca volvulus Huntingtin homolog 0.0127 0.0457 0.192
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0172 0.0659 0.1741
Trichomonas vaginalis alpha-glucosidase, putative 0.0154 0.0577 0.1506
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0101 0.0142
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.0361 0.4411
Trypanosoma cruzi metacaspase, putative 0.0047 0.0101 0.0821
Echinococcus multilocularis dna polymerase eta 0.0048 0.0105 0.0105
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0068 0.0194 0.201
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0058 0.0149 0.0479
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.0105 0.0176
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0069 0.0052
Schistosoma mansoni caspase-7 (C14 family) 0.0125 0.0446 0.0446
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0058 0.0149 0.1661
Leishmania major hypothetical protein, conserved 0.004 0.007 0.0396
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0069 0.0254
Brugia malayi RNA, U transporter 1 0.0605 0.2584 0.5426
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0642 0.2748 0.2748
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.0361 0.378
Loa Loa (eye worm) thioredoxin reductase 0.0196 0.0765 0.07
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0089 0.029 0.3733
Echinococcus granulosus zinc finger protein 0.0025 0.0003 0.0003
Trichomonas vaginalis alpha-glucosidase, putative 0.0154 0.0577 0.1506
Echinococcus granulosus expressed protein 0.0036 0.0051 0.0051
Brugia malayi Probable ClpP-like protease 0.0168 0.064 0.1308
Trypanosoma brucei glucosidase, putative 0.0154 0.0577 0.6605
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.0528 0.1071
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0131 0.1236
Plasmodium falciparum importin beta, putative 0.0213 0.0838 1
Onchocerca volvulus 0.0402 0.1679 0.7315
Brugia malayi hypothetical protein 0.0068 0.0194 0.0364
Schistosoma mansoni ferritin light chain 0.0036 0.0051 0.0051
Giardia lamblia NADH oxidase lateral transfer candidate 0.0068 0.0194 0.2866
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0528 0.0528
Trichomonas vaginalis glucosylceramidase, putative 0.082 0.3543 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.082 0.3543 0.7458
Trichomonas vaginalis sucrase-isomaltase, putative 0.0154 0.0577 0.1506
Schistosoma mansoni caspase-7 (C14 family) 0.0091 0.0297 0.0297
Brugia malayi Importin beta-1 subunit 0.0213 0.0838 0.1728
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0448 0.1883 0.8918
Brugia malayi kap beta 3 protein 0.004 0.007 0.0102
Echinococcus granulosus muscleblind protein 0.109 0.4743 0.4743
Echinococcus granulosus translational activator gcn1 0.004 0.007 0.007
Leishmania major DNA polymerase eta, putative 0.0048 0.0105 0.0881
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0154 0.0577 0.2035
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0047 0.0101 0.0101
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0134 0.0486 0.0419
Onchocerca volvulus Cell death protein 3 homolog 0.0091 0.0297 0.1211
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0068 0.0194 0.162
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0134 0.0486 0.6143
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0228 0.0864
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0068 0.0194 0.0364
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0228 0.0228
Echinococcus multilocularis muscleblind protein 1 0.109 0.4743 0.4743
Loa Loa (eye worm) importin-beta domain-containing protein 0.004 0.007 0.0001
Echinococcus multilocularis lysosomal alpha glucosidase 0.0694 0.2982 0.2982
Trypanosoma cruzi hypothetical protein, conserved 0.0154 0.0577 0.7407
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0228 0.2581
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0068 0.0194 0.162
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0168 0.064 1
Brugia malayi jmjC domain containing protein 0.0084 0.0263 0.051
Trichomonas vaginalis glucosylceramidase, putative 0.0538 0.2287 0.6404
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0047 0.0101 0.0167
Echinococcus granulosus neutral alpha glucosidase AB 0.0154 0.0577 0.0577
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.076 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0101 0.0142
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0192 0.0192
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0195 0.076 0.3453
Loa Loa (eye worm) hypothetical protein 0.0428 0.1797 0.1739
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0192 0.0124
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.0528 0.0462
Brugia malayi jmjC domain containing protein 0.0084 0.0263 0.051
Loa Loa (eye worm) jmjC domain-containing protein 0.0084 0.0263 0.0195
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0154 0.0577 0.861
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0068 0.0194 0.0194
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0068 0.0194 0.162
Trichomonas vaginalis glucosylceramidase, putative 0.0538 0.2287 0.6404
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.017 0.1773
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0102 0.0102
Echinococcus multilocularis caspase 2 0.0091 0.0297 0.0297
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0168 0.064 0.8297
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0642 0.2748 0.2748
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0528 0.0528
Echinococcus granulosus phd:f box containing protein 0.0084 0.0263 0.0263
Plasmodium vivax ataxin-2 like protein, putative 0.0105 0.0361 0.4147
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0134 0.0486 0.6143
Toxoplasma gondii thioredoxin reductase 0.0196 0.0765 0.2723
Trichomonas vaginalis alpha-glucosidase, putative 0.0057 0.0147 0.0273
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0068 0.0194 0.1609
Loa Loa (eye worm) hypothetical protein 0.005 0.0114 0.0045
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0228 0.0864
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0091 0.0296 0.0296
Toxoplasma gondii NADPH-glutathione reductase 0.0068 0.0194 0.063
Entamoeba histolytica Ran family GTPase 0.0134 0.0486 0.7062
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0102 0.0102
Loa Loa (eye worm) beta-lactamase 0.0076 0.0228 0.016
Echinococcus granulosus caspase 8 0.0047 0.0101 0.0101
Trypanosoma cruzi importin beta-1 subunit, putative 0.0172 0.0659 0.854
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0022 0.0022
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0428 0.1797 0.1797
Schistosoma mansoni hypothetical protein 0.2271 1 1
Schistosoma mansoni ferritin light chain 0.0036 0.0051 0.0051
Schistosoma mansoni apoferritin-2 0.0036 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0047 0.0101 0.0032
Brugia malayi Muscleblind-like protein 0.109 0.4743 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0134 0.0486 0.0486
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0069 0.0173
Brugia malayi Cell death protein 3 precursor 0.0091 0.0297 0.0581
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0228 0.2525
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0196 0.1652
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.004 0.007 0.0013
Onchocerca volvulus 0.0076 0.0228 0.091
Trypanosoma cruzi trypanothione reductase, putative 0.0196 0.0765 1
Trichomonas vaginalis glutathione reductase, putative 0.0068 0.0194 0.0408
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0069 0.0052
Brugia malayi jmjC domain containing protein 0.0313 0.1286 0.2676
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0105 0.0303
Plasmodium falciparum metacaspase-like protein 0.0047 0.0101 0.04
Mycobacterium ulcerans hypothetical protein 0.0076 0.0228 0.2495
Trypanosoma brucei metacaspase MCA3 0.0047 0.0101 0.0412
Trypanosoma cruzi metacaspase, putative 0.0047 0.0101 0.0821
Brugia malayi beta-lactamase family protein 0.0076 0.0228 0.0436
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0134 0.0486 0.17
Toxoplasma gondii ABC1 family protein 0.0076 0.0228 0.0756
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0497 0.2106 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0172 0.0659 0.1741
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0105 0.0303
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0168 0.064 0.064
Schistosoma mansoni peptidase Clp (S14 family) 0.0168 0.064 0.064
Entamoeba histolytica HEAT repeat domain containing protein 0.004 0.007 0.0016
Schistosoma mansoni aldehyde dehydrogenase 0.0195 0.076 0.076
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.0805 0.074
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.011 0.0382 0.1611
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.2271 1 1
Trichomonas vaginalis importin beta-1, putative 0.0172 0.0659 0.1741
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0084 0.0263 0.3062
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.004 0.007 0.0013
Brugia malayi hypothetical protein 0.0127 0.0457 0.0921
Schistosoma mansoni zinc finger protein 0.0025 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0076 0.0228 0.016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.076 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0194 0.2105
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0068 0.0194 0.2422
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0196 0.2139
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0168 0.064 0.064
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.082 0.3543 0.3498
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0101 0.0966
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.0101 0.0289
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0642 0.2748 0.2748
Trichomonas vaginalis glucosylceramidase, putative 0.0538 0.2287 0.6404
Echinococcus granulosus histone acetyltransferase KAT2B 0.015 0.056 0.056
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0313 0.1286 0.1286
Loa Loa (eye worm) hypothetical protein 0.0084 0.0263 0.0195
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0192 0.0124
Loa Loa (eye worm) hypothetical protein 0.109 0.4743 0.4706
Echinococcus granulosus tar DNA binding protein 0.0068 0.0192 0.0192
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0069 0.0382
Loa Loa (eye worm) hypothetical protein 0.0048 0.0105 0.0035
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0042 0.0071
Schistosoma mansoni alpha-glucosidase 0.0598 0.2552 0.2552
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.076 1
Echinococcus multilocularis translational activator gcn1 0.004 0.007 0.007

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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