Detailed information for compound 789363

Basic information

Technical information
  • TDR Targets ID: 789363
  • Name: 4-(4-bromobenzoyl)-7-chloro-5-(4-fluorophenyl )-3,5-dihydro-1H-1,4-benzodiazepin-2-one
  • MW: 473.722 | Formula: C22H15BrClFN2O2
  • H donors: 1 H acceptors: 2 LogP: 4.97 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CN(C(=O)c2ccc(cc2)Br)C(c2c(N1)ccc(c2)Cl)c1ccc(cc1)F
  • InChi: 1S/C22H15BrClFN2O2/c23-15-5-1-14(2-6-15)22(29)27-12-20(28)26-19-10-7-16(24)11-18(19)21(27)13-3-8-17(25)9-4-13/h1-11,21H,12H2,(H,26,28)
  • InChiKey: SEIVXYCRYJKUTL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(4-bromophenyl)-oxomethyl]-7-chloro-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one
  • 4-(4-bromophenyl)carbonyl-7-chloro-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one
  • Oprea1_640719
  • EU-0054471

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni protein phosphatase 2C 0.0083 0.0265 0.0265
Brugia malayi Glycosyl hydrolases family 31 protein 0.0688 0.296 0.6206
Mycobacterium ulcerans beta-lactamase 0.0076 0.023 0.2488
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0068 0.0197 0.211
Leishmania major glycosyl hydrolase-like protein 0.0057 0.0146 0.142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0198 0.1682
Echinococcus multilocularis lysosomal alpha glucosidase 0.0688 0.296 0.296
Loa Loa (eye worm) hypothetical protein 0.0167 0.0635 0.0571
Schistosoma mansoni ferritin 0.0036 0.0054 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0106 0.0149
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0167 0.0635 0.2232
Echinococcus granulosus importin 5 0.004 0.0072 0.0072
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0499 0.2114 1
Plasmodium vivax importin-beta 2, putative 0.0212 0.084 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.011 0.0306
Schistosoma mansoni jumonji/arid domain-containing protein 0.0315 0.1296 0.1296
Echinococcus granulosus caspase 3 0.0079 0.0243 0.0243
Trypanosoma cruzi metacaspase, putative 0.0048 0.0106 0.0864
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.0364 0.442
Trichomonas vaginalis glucosylceramidase, putative 0.0541 0.2301 0.6404
Mycobacterium tuberculosis Conserved protein 0.0076 0.023 0.0872
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0068 0.0197 0.2455
Schistosoma mansoni jumonji/arid domain-containing protein 0.0315 0.1296 0.1296
Brugia malayi beta-lactamase family protein 0.0076 0.023 0.0432
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0483 0.2046 0.9668
Trypanosoma brucei importin beta-1 subunit, putative 0.0212 0.084 1
Onchocerca volvulus 0.0045 0.0091 0.0288
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0167 0.0635 0.734
Schistosoma mansoni caspase-7 (C14 family) 0.0126 0.0457 0.0457
Brugia malayi kap beta 3 protein 0.004 0.0072 0.0098
Trichomonas vaginalis glucosylceramidase, putative 0.0541 0.2301 0.6404
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0057 0.0146 0.053
Echinococcus granulosus caspase 2 0.0092 0.0305 0.0305
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0195 0.0762 0.9904
Loa Loa (eye worm) acetyltransferase 0.0159 0.0603 0.0538
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.023 0.2488
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0197 0.0769 0.3483
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0198 0.1682
Echinococcus multilocularis caspase 8 0.0048 0.0106 0.0106
Schistosoma mansoni aldehyde dehydrogenase 0.0195 0.0762 0.0762
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0194 0.0194
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0078 0.0242 0.2665
Brugia malayi Pre-SET motif family protein 0.0208 0.082 0.1679
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.023 0.2488
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0026 0.0026
Echinococcus multilocularis neutral alpha glucosidase AB 0.0153 0.0574 0.0574
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.023 0.023
Schistosoma mansoni phosphatidylserine receptor 0.0083 0.0265 0.0265
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0159 0.0603 0.0603
Echinococcus multilocularis geminin 0.1238 0.5407 0.5407
Schistosoma mansoni inositol monophosphatase 0.0039 0.0068 0.0068
Leishmania major alpha glucosidase II subunit, putative 0.0153 0.0574 0.7306
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0057 0.0149 0.1634
Loa Loa (eye worm) hypothetical protein 0.1091 0.4754 0.4718
Echinococcus multilocularis caspase 3 0.0079 0.0243 0.0243
Brugia malayi jmjC domain containing protein 0.0315 0.1296 0.2687
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0167 0.0635 1
Schistosoma mansoni alpha glucosidase 0.0153 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0083 0.0265 0.0198
Treponema pallidum NADH oxidase 0.0068 0.0197 0.2455
Mycobacterium tuberculosis Conserved protein 0.0076 0.023 0.0872
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0198 0.1682
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0068 0.0343
Schistosoma mansoni importin-beta 2 0.004 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.0023
Schistosoma mansoni hypothetical protein 0.1238 0.5407 0.5407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0198 0.1682
Plasmodium falciparum glutathione reductase 0.0197 0.0769 0.9079
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0134 0.0489 0.5454
Loa Loa (eye worm) hypothetical protein 0.0048 0.0106 0.0038
Schistosoma mansoni importin beta-1 0.0212 0.084 0.084
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0109 0.038 0.1597
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0068 0.0197 0.1662
Brugia malayi jmjC domain containing protein 0.0083 0.0265 0.0505
Echinococcus granulosus ferritin 0.0036 0.0054 0.0054
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0167 0.0635 0.8213
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0068 0.0197 0.211
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0064 0.0064
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0109 0.038 0.1597
Plasmodium vivax hypothetical protein, conserved 0.0076 0.023 0.2507
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0091 0.0298 0.0298
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0078 0.0242 0.2743
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0643 0.2757 0.2757
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0088 0.0285 0.3659
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0107 0.0107
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0107 0.0107
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0134 0.0489 0.1696
Loa Loa (eye worm) hypothetical protein 0.0047 0.0103 0.0035
Echinococcus granulosus jumonji domain containing 1A 0.0083 0.0265 0.0265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0198 0.1682
Toxoplasma gondii LsmAD domain-containing protein 0.0106 0.0364 0.1238
Echinococcus granulosus translational activator gcn1 0.004 0.0072 0.0072
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0106 0.0149
Trichomonas vaginalis alpha-glucosidase, putative 0.0057 0.0146 0.0264
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.023 0.0432
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0106 0.0149
Plasmodium falciparum thioredoxin reductase 0.0197 0.0769 0.9079
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0198 0.2131
Echinococcus granulosus apoptotic protease activating factor 1 0.0045 0.0091 0.0091
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0499 0.2114 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0197 0.211
Onchocerca volvulus 0.0076 0.023 0.0897
Loa Loa (eye worm) kap beta 3 protein 0.004 0.0072 0.0004
Loa Loa (eye worm) jmjC domain-containing protein 0.0083 0.0265 0.0198
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0068 0.0197 0.1622
Trypanosoma brucei trypanothione reductase 0.0197 0.0769 0.9083
Loa Loa (eye worm) hypothetical protein 0.0057 0.0146 0.0079
Schistosoma mansoni ran 0.0134 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0041 0.0075 0.0007
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0085 0.0274 0.0274
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0068 0.0197 0.1662
Schistosoma mansoni hypothetical protein 0.1238 0.5407 0.5407
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0057 0.0146 0.0264
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0021 0.0021
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0106 0.0149
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0057 0.0149 0.151
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0195 0.0762 0.0762
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0068 0.0042
Toxoplasma gondii melibiase subfamily protein 0.0643 0.2757 1
Trypanosoma brucei Metacaspase-4 0.0048 0.0106 0.049
Echinococcus granulosus tar DNA binding protein 0.0067 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0125 0.045 0.0384
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0429 0.1803 0.1803
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0078 0.0242 0.0933
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0167 0.0635 1
Trypanosoma cruzi metacaspase, putative 0.0048 0.0106 0.0864
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.023 0.257
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0449 0.1891 0.892
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0198 0.1682
Echinococcus granulosus JmjC domain containing protein 4 0.0083 0.0265 0.0265
Brugia malayi acetyltransferase, GNAT family protein 0.0159 0.0603 0.122
Loa Loa (eye worm) hypothetical protein 0.0106 0.0364 0.0298
Brugia malayi Bromodomain containing protein 0.0084 0.0266 0.0508
Trichomonas vaginalis alpha-glucosidase, putative 0.0057 0.0146 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0106 0.0149
Mycobacterium tuberculosis Probable dehydrogenase 0.0449 0.1891 0.892
Trichomonas vaginalis glucosylceramidase, putative 0.0824 0.3564 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1674 0.7354 0.7354
Trichomonas vaginalis glucosylceramidase, putative 0.0824 0.3564 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0533 0.0533
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0533 0.0533
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0449 0.1891 0.892
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0533 0.0533
Schistosoma mansoni DNA polymerase eta 0.0048 0.0107 0.0107
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.0364 0.3805
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0083 0.0265 0.0265
Trichomonas vaginalis glucosylceramidase, putative 0.057 0.2431 0.6773
Plasmodium vivax thioredoxin reductase, putative 0.0197 0.0769 0.9131
Entamoeba histolytica HEAT repeat domain containing protein 0.004 0.0072 0.0063
Echinococcus multilocularis expressed protein 0.0036 0.0054 0.0054
Echinococcus granulosus thioredoxin glutathione reductase 0.0197 0.0769 0.0769
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0106 0.0149
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0068 0.0343
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0057 0.0149 0.1
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.023 0.0502
Trichomonas vaginalis glucosylceramidase, putative 0.0541 0.2301 0.6404
Trichomonas vaginalis maltase-glucoamylase, putative 0.0153 0.0574 0.1481
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.011 0.011
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0643 0.2757 0.2757
Brugia malayi hypothetical protein 0.0125 0.045 0.0897
Loa Loa (eye worm) hypothetical protein 0.0076 0.023 0.0163
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0068 0.0197 0.2016
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0106 0.0149
Schistosoma mansoni apoferritin-2 0.0036 0.0054 0.0054
Toxoplasma gondii aldehyde dehydrogenase 0.0195 0.0762 0.2696
Echinococcus multilocularis snurportin 1 0.2268 1 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0126 0.0457 0.0457
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.023 0.0163
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0134 0.0489 0.098
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.023 0.0872
Trypanosoma cruzi trypanothione reductase, putative 0.0068 0.0197 0.211
Brugia malayi glutathione reductase 0.0197 0.0769 0.1572
Onchocerca volvulus Huntingtin homolog 0.0125 0.045 0.1864
Schistosoma mansoni ran 0.0134 0.0489 0.0489
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0194 0.0194
Loa Loa (eye worm) RNA binding protein 0.0067 0.0194 0.0126
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0048 0.0106 0.0106
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.023 0.0502
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0057 0.0146 0.0264
Loa Loa (eye worm) jmjC domain-containing protein 0.0083 0.0265 0.0198
Schistosoma mansoni hypothetical protein 0.0047 0.0104 0.0104
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0068 0.0343
Schistosoma mansoni caspase-3 (C14 family) 0.0126 0.0457 0.0457
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0134 0.0489 1
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0948 0.2547
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0026 0.0026
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0153 0.0574 0.0509
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0126 0.0457 0.0457
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.0107 0.0503
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0134 0.0489 0.5432
Trypanosoma brucei importin beta-1 subunit, putative 0.0212 0.084 1
Echinococcus granulosus geminin 0.1238 0.5407 0.5407
Trichomonas vaginalis alpha-glucosidase, putative 0.0057 0.0146 0.0264
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0068 0.0197 0.071
Brugia malayi Glycosyl hydrolases family 31 protein 0.0153 0.0574 0.1158
Loa Loa (eye worm) hypothetical protein 0.0076 0.023 0.0163
Brugia malayi hypothetical protein 0.0068 0.0197 0.0362
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0048 0.0106 0.0294
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0081 0.0218
Trichomonas vaginalis glucosylceramidase, putative 0.0541 0.2301 0.6404
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0134 0.0489 0.5691
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0068 0.0197 0.2097
Loa Loa (eye worm) glutathione reductase 0.0197 0.0769 0.0706
Brugia malayi hypothetical protein 0.0045 0.0091 0.0139
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0078 0.0242 0.0458
Echinococcus granulosus lysine specific demethylase 6a 0.0083 0.0265 0.0265
Trichomonas vaginalis alpha-glucosidase, putative 0.0153 0.0574 0.1481
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0153 0.0574 0.1481
Onchocerca volvulus 0.0237 0.0948 0.4051
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0078 0.0242 0.0242
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0036 0.0054 0.0018
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0313 0.1287 0.1287
Trypanosoma brucei glycosyl hydrolase-like protein 0.0057 0.0146 0.1013
Brugia malayi jmjC domain containing protein 0.0083 0.0265 0.0505
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0153 0.0574 0.8529
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0194 0.0194
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0068 0.0197 0.0361
Loa Loa (eye worm) hypothetical protein 0.0083 0.0265 0.0198
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0036 0.0054 0.0018
Trichomonas vaginalis alpha-glucosidase, putative 0.0153 0.0574 0.1481
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0198 0.1682
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.023 0.0872
Brugia malayi TAR-binding protein 0.0067 0.0194 0.0355
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0194 0.0194
Plasmodium falciparum metacaspase 1 0.0048 0.0106 0.0444
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0106 0.0986
Onchocerca volvulus Cell death protein 3 homolog 0.0092 0.0305 0.1225
Leishmania major hypothetical protein, conserved 0.0083 0.0265 0.3051
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.011 0.0159
Echinococcus multilocularis JmjC domain containing protein 4 0.0083 0.0265 0.0265
Schistosoma mansoni ferritin light chain 0.0036 0.0054 0.0054
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0068 0.0042
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.0364 0.3805
Echinococcus granulosus GTP binding nuclear protein Ran 0.0134 0.0489 0.0489
Mycobacterium tuberculosis Probable oxidoreductase 0.0499 0.2114 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0107 0.0039
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.005 0.0116 0.0191
Trichomonas vaginalis glucosylceramidase, putative 0.057 0.2431 0.6773
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0533 0.0533
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0533 0.0533
Schistosoma mansoni alpha-glucosidase 0.0592 0.2533 0.2533
Echinococcus multilocularis thioredoxin glutathione reductase 0.0197 0.0769 0.0769
Echinococcus multilocularis apoptotic protease activating factor 1 0.0045 0.0091 0.0091
Echinococcus multilocularis dna polymerase eta 0.0048 0.0107 0.0107
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0057 0.0146 0.142
Echinococcus multilocularis jumonji domain containing 1A 0.0083 0.0265 0.0265
Brugia malayi Inositol-1 0.0039 0.0068 0.009
Brugia malayi Melibiase family protein 0.0429 0.1803 0.3758
Schistosoma mansoni apoferritin-2 0.0036 0.0054 0.0054
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0167 0.0635 0.2836
Echinococcus multilocularis peptidase Clp (S14 family) 0.0109 0.038 0.038
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.023 0.023
Echinococcus multilocularis muscleblind protein 0.1091 0.4754 0.4754
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0106 0.0149
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.023 0.0872
Brugia malayi hypothetical protein 0.0106 0.0364 0.0715
Mycobacterium leprae conserved hypothetical protein 0.0076 0.023 0.0872
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0688 0.296 0.2912
Plasmodium falciparum metacaspase-like protein 0.0048 0.0106 0.0444
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0068 0.0197 0.1662
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0104 0.0104
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0068 0.0197 0.1622
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0078 0.0242 0.2665
Trichomonas vaginalis alpha-glucosidase, putative 0.0153 0.0574 0.1481
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0083 0.0265 0.0875
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.011 0.1028
Plasmodium falciparum thioredoxin reductase 0.0068 0.0197 0.1622
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.023 0.0502
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.023 0.023
Leishmania major trypanothione reductase 0.0197 0.0769 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0068 0.0197 0.2828
Echinococcus granulosus lysine specific demethylase 5A 0.0315 0.1296 0.1296
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0068 0.0197 0.2097
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0036 0.0054 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0198 0.2131
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0194 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0106 0.0149
Trypanosoma cruzi metacaspase, putative 0.0048 0.0106 0.0864
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0167 0.0635 0.7491
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0106 0.0149
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.0574 0.7306
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0068 0.0197 0.211
Leishmania major cathepsin L-like protease 0.0068 0.0198 0.2131
Brugia malayi beta-lactamase family protein 0.0076 0.023 0.0432
Schistosoma mansoni bromodomain containing protein 0.0071 0.0211 0.0211
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0057 0.0146 0.1319
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0265 0.0265
Trichomonas vaginalis glucosylceramidase, putative 0.0824 0.3564 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0085 0.0274 0.0274
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0068 0.0197 0.0197
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.023 0.0872
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0167 0.0635 0.2232
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.0107 0.0172
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0197 0.211
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0159 0.0603 0.0603
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0643 0.2757 0.2757
Entamoeba histolytica hypothetical protein 0.0172 0.0661 1
Leishmania major metacaspase, putative 0.0048 0.0106 0.0864
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0068 0.0197 0.211
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0078 0.0242 0.0242
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0106 0.0149
Brugia malayi Thioredoxin reductase 0.0197 0.0769 0.1572
Plasmodium vivax JmjC domain containing protein 0.0083 0.0265 0.2936
Trichomonas vaginalis alpha-glucosidase, putative 0.0057 0.0146 0.0264
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0197 0.211
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0198 0.2131
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0048 0.0106 0.017
Onchocerca volvulus 0.0076 0.023 0.0897
Toxoplasma gondii HEAT repeat-containing protein 0.0212 0.084 0.298
Loa Loa (eye worm) hypothetical protein 0.0212 0.084 0.0777
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0195 0.0762 0.0762
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0198 0.2131
Echinococcus multilocularis lysine specific demethylase 5A 0.0313 0.1287 0.1287
Echinococcus granulosus peptidase Clp S14 family 0.0109 0.038 0.038
Loa Loa (eye worm) hypothetical protein 0.0125 0.045 0.0384
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0198 0.1682
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.004 0.0072 0.0048
Schistosoma mansoni ferritin 0.0036 0.0054 0.0054
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0643 0.2757 0.2757
Leishmania major importin beta-1 subunit, putative 0.0172 0.0661 0.8507
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0429 0.1803 0.4983
Entamoeba histolytica Ran family GTPase 0.0134 0.0489 0.7102
Schistosoma mansoni hypothetical protein 0.0045 0.0091 0.0091
Echinococcus granulosus transportin 1 0.004 0.0072 0.0072
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0068 0.0197 0.0197
Plasmodium vivax glutathione reductase, putative 0.0197 0.0769 0.9131
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0068 0.0197 0.0625
Echinococcus multilocularis phd:f box containing protein 0.0083 0.0265 0.0265
Schistosoma mansoni jumonji domain containing protein 0.0313 0.1287 0.1287
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0081 0.012
Loa Loa (eye worm) hypothetical protein 0.0048 0.0107 0.0039
Trichomonas vaginalis maltase-glucoamylase, putative 0.0057 0.0146 0.0264
Mycobacterium ulcerans hypothetical protein 0.0076 0.023 0.2488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0198 0.1682
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0167 0.0635 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0197 0.211
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0449 0.1891 0.892
Trichomonas vaginalis alpha-glucosidase, putative 0.0057 0.0146 0.0264
Loa Loa (eye worm) hypothetical protein 0.0076 0.023 0.0163
Schistosoma mansoni zinc finger protein 0.0025 0.0003 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.023 0.0502
Leishmania major hypothetical protein, conserved 0.0106 0.0364 0.442
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0106 0.0149
Loa Loa (eye worm) hypothetical protein 0.0076 0.023 0.0163
Trichomonas vaginalis esterase, putative 0.0076 0.023 0.0502
Echinococcus multilocularis lysine specific demethylase 6a 0.0083 0.0265 0.0265
Brugia malayi Glycosyl hydrolases family 31 protein 0.0057 0.0146 0.0255
Trypanosoma cruzi metacaspase, putative 0.0048 0.0106 0.0864
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.0364 0.442
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0107 0.0877
Loa Loa (eye worm) hypothetical protein 0.0049 0.0113 0.0045
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0068 0.0197 0.0197
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0057 0.0149 0.0479
Trypanosoma brucei metacaspase MCA3 0.0048 0.0106 0.049
Echinococcus multilocularis translational activator gcn1 0.004 0.0072 0.0072
Onchocerca volvulus Huntingtin homolog 0.0125 0.045 0.1864
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.004 0.0072 0.0048
Loa Loa (eye worm) hypothetical protein 0.0076 0.023 0.0163
Echinococcus granulosus importin subunit beta 1 0.0212 0.084 0.084
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0064 0.0064
Echinococcus multilocularis importin subunit beta 1 0.0212 0.084 0.084
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.023 0.2095
Trichomonas vaginalis glucosylceramidase, putative 0.0824 0.3564 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0153 0.0574 0.1481
Mycobacterium leprae Probable lipase LipE 0.0076 0.023 0.0872
Toxoplasma gondii ABC1 family protein 0.0076 0.023 0.0747
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0078 0.0242 0.0242
Echinococcus granulosus caspase 0.0126 0.0457 0.0457
Trichomonas vaginalis alpha-glucosidase, putative 0.0153 0.0574 0.1481
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0172 0.0661 0.1729
Trichomonas vaginalis alpha-glucosidase, putative 0.0153 0.0574 0.1481
Echinococcus multilocularis ferritin 0.0036 0.0054 0.0054
Brugia malayi Probable ClpP-like protease 0.0167 0.0635 0.1289
Trypanosoma brucei glucosidase, putative 0.0153 0.0574 0.6549
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.0533 0.1072
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0133 0.1231
Plasmodium falciparum importin beta, putative 0.0212 0.084 1
Onchocerca volvulus 0.0398 0.1667 0.7212
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0151 0.0083
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0068 0.0251
Plasmodium vivax transportin, putative 0.004 0.0072 0.0567
Brugia malayi RNA, U transporter 1 0.0604 0.2585 0.5413
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0643 0.2757 0.2757
Trypanosoma brucei PAB1-binding protein , putative 0.0106 0.0364 0.3835
Loa Loa (eye worm) thioredoxin reductase 0.0197 0.0769 0.0706
Loa Loa (eye worm) hypothetical protein 0.0088 0.0285 0.0218
Echinococcus multilocularis zinc finger protein 0.0025 0.0003 0.0003
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0194 0.0126
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0088 0.0285 0.3659
Brugia malayi Bromodomain containing protein 0.0045 0.0092 0.014
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0194 0.0194
Mycobacterium tuberculosis Probable reductase 0.0449 0.1891 0.892
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0068 0.0197 0.2455
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0449 0.1891 0.892
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0083 0.0265 0.3051
Echinococcus granulosus lysosomal alpha glucosidase 0.0688 0.296 0.296
Leishmania major cathepsin L-like protease 0.0068 0.0198 0.2131
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0107 0.0107
Trichomonas vaginalis glucosylceramidase, putative 0.0824 0.3564 1
Schistosoma mansoni ferritin 0.0036 0.0054 0.0054
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.005 0.0116 0.0191
Loa Loa (eye worm) importin-beta domain-containing protein 0.004 0.0072 0.0004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.023 0.0872
Mycobacterium ulcerans lipase LipD 0.0076 0.023 0.2488
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0026 0.0026
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0057 0.0146 0.142
Echinococcus multilocularis transportin 1 0.004 0.0072 0.0072
Brugia malayi jmjC domain containing protein 0.0083 0.0265 0.0505
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0083 0.0265 0.3051
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0068 0.0197 0.211
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.023 0.0872
Plasmodium falciparum JmjC domain-containing protein, putative 0.0083 0.0265 0.2511
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0106 0.0149
Onchocerca volvulus Glucosylceramidase homolog 0.0541 0.2301 1
Schistosoma mansoni phd/f-box containing protein 0.0083 0.0265 0.0265
Loa Loa (eye worm) jmjC domain-containing protein 0.0315 0.1296 0.1237
Schistosoma mansoni inositol monophosphatase 0.0039 0.0068 0.0068
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0068 0.0197 0.2016
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.0533 0.0467
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0083 0.0265 0.0875
Loa Loa (eye worm) jmjC domain-containing protein 0.0083 0.0265 0.0198
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0153 0.0574 0.8529
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0194 0.0126
Trichomonas vaginalis glutathione reductase, putative 0.0068 0.0197 0.0407
Trichomonas vaginalis glucosylceramidase, putative 0.0541 0.2301 0.6404
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0172 0.1766
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0107 0.0107
Plasmodium falciparum glutathione reductase 0.0068 0.0197 0.1622
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0195 0.0762 0.345
Loa Loa (eye worm) hypothetical protein 0.0429 0.1803 0.1746
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.011 0.0159
Loa Loa (eye worm) hypothetical protein 0.0076 0.023 0.0163
Brugia malayi Cell death protein 3 precursor 0.0092 0.0305 0.059
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0068 0.0197 0.211
Trichomonas vaginalis ran, putative 0.0134 0.0489 0.124
Trypanosoma cruzi metacaspase 5, putative 0.0048 0.0106 0.0864
Trypanosoma brucei metacaspase 0.0048 0.0106 0.049
Echinococcus multilocularis caspase 2 0.0092 0.0305 0.0305
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0167 0.0635 0.8213
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0533 0.0533
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0643 0.2757 0.2757
Echinococcus granulosus phd:f box containing protein 0.0083 0.0265 0.0265
Plasmodium vivax ataxin-2 like protein, putative 0.0106 0.0364 0.4156
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0134 0.0489 0.6141
Toxoplasma gondii thioredoxin reductase 0.0197 0.0769 0.2721
Toxoplasma gondii hypothetical protein 0.0057 0.0149 0.045
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0068 0.0197 0.1662
Trichomonas vaginalis sucrase-isomaltase, putative 0.0153 0.0574 0.1481
Loa Loa (eye worm) hypothetical protein 0.0092 0.0305 0.0238
Brugia malayi Importin beta-1 subunit 0.0212 0.084 0.1721
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0449 0.1891 0.892
Leishmania major hypothetical protein, conserved 0.004 0.0072 0.0394
Echinococcus granulosus muscleblind protein 0.1091 0.4754 0.4754
Toxoplasma gondii HEAT repeat-containing protein 0.004 0.0072 0.0169
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0194 0.0194
Schistosoma mansoni ferritin light chain 0.0036 0.0054 0.0054
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0194 0.0355
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0533 0.0533
Trichomonas vaginalis glucosylceramidase, putative 0.0824 0.3564 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0824 0.3564 0.7483
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0198 0.1682
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.023 0.0872
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0068 0.0068
Echinococcus multilocularis muscleblind protein 1 0.1091 0.4754 0.4754
Echinococcus multilocularis lysosomal alpha glucosidase 0.0688 0.296 0.296
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.0574 0.7306
Brugia malayi beta-lactamase 0.0076 0.023 0.0432
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0083 0.0265 0.2547
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0197 0.211
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0167 0.0635 1
Trichomonas vaginalis glucosylceramidase, putative 0.0541 0.2301 0.6404
Echinococcus granulosus dna polymerase eta 0.0048 0.0107 0.0107
Echinococcus granulosus neutral alpha glucosidase AB 0.0153 0.0574 0.0574
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.0762 1
Leishmania major DNA polymerase eta, putative 0.0048 0.0107 0.0877
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0153 0.0574 0.2005
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0104 0.0104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0198 0.1682
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0134 0.0489 0.0424
Toxoplasma gondii Alpha-galactosidase 0.0091 0.0298 0.0998
Leishmania major GTP-binding protein, putative 0.0134 0.0489 0.6141
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.023 0.023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0068 0.0197 0.211
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0167 0.0635 0.0635
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0068 0.0197 0.2016
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0824 0.3564 0.3519
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0167 0.0635 0.0635
Trypanosoma cruzi metacaspase 5, putative 0.0048 0.0106 0.0864
Schistosoma mansoni peptidase Clp (S14 family) 0.0167 0.0635 0.0635
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.082 0.0757
Schistosoma mansoni aldehyde dehydrogenase 0.0195 0.0762 0.0762
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0068 0.0042
Trichomonas vaginalis importin beta-1, putative 0.0172 0.0661 0.1729
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0109 0.038 0.1597
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.2268 1 1
Brugia malayi jmjC domain containing protein 0.0083 0.0265 0.0505
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0068 0.0068
Echinococcus multilocularis caspase 0.0126 0.0457 0.0457
Echinococcus granulosus zinc finger protein 0.0025 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.023 0.257
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.0762 1
Trichomonas vaginalis mercuric reductase, putative 0.0068 0.0197 0.0407
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0194 0.0194
Toxoplasma gondii HEAT repeat-containing protein 0.004 0.0072 0.0169
Plasmodium vivax metacaspase 1, putative 0.0048 0.0106 0.0986
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0043 0.0064
Schistosoma mansoni alpha-glucosidase 0.0592 0.2533 0.2533
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0068 0.0155
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.0762 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0048 0.0106 0.0294
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0048 0.0106 0.0149
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0643 0.2757 0.2757
Trichomonas vaginalis glucosylceramidase, putative 0.0541 0.2301 0.6404
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.0572 0.0572
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0313 0.1287 0.1287
Loa Loa (eye worm) hypothetical protein 0.0083 0.0265 0.0198
Leishmania major cathepsin L-like protease 0.0068 0.0198 0.2131
Loa Loa (eye worm) hypothetical protein 0.1091 0.4754 0.4718
Echinococcus granulosus expressed protein 0.0036 0.0054 0.0054
Schistosoma mansoni ferritin 0.0036 0.0054 0.0054
Trypanosoma brucei metacaspase 5, putative 0.0048 0.0106 0.049
Brugia malayi Muscleblind-like protein 0.1091 0.4754 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0134 0.0489 0.0489
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0068 0.0206
Schistosoma mansoni caspase-7 (C14 family) 0.0092 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0075 0.0229 0.0162
Toxoplasma gondii NADPH-glutathione reductase 0.0068 0.0197 0.0625
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.023 0.0502
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0048 0.0106 0.0294
Trypanosoma cruzi importin beta-1 subunit, putative 0.0172 0.0661 0.8507
Brugia malayi PHD-finger family protein 0.003 0.0028 0.0005
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0429 0.1803 0.1803
Schistosoma mansoni hypothetical protein 0.2268 1 1
Leishmania major hypothetical protein, conserved 0.0076 0.023 0.257
Echinococcus granulosus caspase 8 0.0048 0.0106 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0106 0.0149
Loa Loa (eye worm) beta-lactamase 0.0076 0.023 0.0163
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0134 0.0489 0.6141
Mycobacterium tuberculosis Conserved protein 0.0076 0.023 0.0872
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0172 0.0661 0.1729
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0499 0.2114 1
Echinococcus multilocularis importin 5 0.004 0.0072 0.0072
Trypanosoma cruzi trypanothione reductase, putative 0.0197 0.0769 1
Onchocerca volvulus 0.0076 0.023 0.0897
Brugia malayi RNA binding protein 0.0067 0.0194 0.0355
Trichomonas vaginalis hypothetical protein 0.004 0.0072 0.0052
Brugia malayi jmjC domain containing protein 0.0313 0.1287 0.2668
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.011 0.0306
Trypanosoma brucei metacaspase MCA2 0.0048 0.0106 0.049

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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