Detailed information for compound 789430

Basic information

Technical information
  • TDR Targets ID: 789430
  • Name: 4-(2-chloro-6-fluorobenzoyl)-7-fluoro-5-(4-fl uorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin- 2-one
  • MW: 430.807 | Formula: C22H14ClF3N2O2
  • H donors: 1 H acceptors: 2 LogP: 4.48 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2ccc(cc2C(N(C1)C(=O)c1c(F)cccc1Cl)c1ccc(cc1)F)F
  • InChi: 1S/C22H14ClF3N2O2/c23-16-2-1-3-17(26)20(16)22(30)28-11-19(29)27-18-9-8-14(25)10-15(18)21(28)12-4-6-13(24)7-5-12/h1-10,21H,11H2,(H,27,29)
  • InChiKey: WQWAZSZHKKDCBS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2-chloro-6-fluoro-benzoyl)-7-fluoro-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one
  • 4-[(2-chloro-6-fluorophenyl)-oxomethyl]-7-fluoro-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one
  • 4-(2-chloro-6-fluoro-phenyl)carbonyl-7-fluoro-5-(4-fluorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one
  • Oprea1_067406

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0169 0.0641 0.0633
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0069 0.0204 0.2008
Loa Loa (eye worm) hypothetical protein 0.0085 0.0274 0.0274
Brugia malayi Glycosyl hydrolases family 31 protein 0.0156 0.0582 0.1159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0206 0.1674
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.024 0.024
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0077 0.004
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.009 0.011
Schistosoma mansoni hypothetical protein 0.0048 0.0114 0.0114
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0037 0.0063 0.0021
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.024 0.0232
Trichomonas vaginalis alpha-glucosidase, putative 0.0156 0.0582 0.1479
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0085 0.0274 0.2549
Loa Loa (eye worm) acetyltransferase 0.0162 0.0609 0.0609
Schistosoma mansoni zinc finger protein 0.0025 0.0012 0.0012
Echinococcus granulosus geminin 0.1261 0.5411 0.5406
Echinococcus multilocularis transportin 1 0.0041 0.0081 0.0072
Trichomonas vaginalis alpha-glucosidase, putative 0.0058 0.0156 0.0264
Trichomonas vaginalis maltase-glucoamylase, putative 0.0156 0.0582 0.1479
Brugia malayi Muscleblind-like protein 0.1112 0.4758 1
Echinococcus granulosus caspase 3 0.008 0.0251 0.0242
Loa Loa (eye worm) jmjC domain-containing protein 0.0321 0.1303 0.1303
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0069 0.0204 0.2445
Trypanosoma cruzi metacaspase 5, putative 0.0049 0.0115 0.0864
Schistosoma mansoni aldehyde dehydrogenase 0.0198 0.0767 0.0767
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0069 0.0204 0.2109
Brugia malayi Pre-SET motif family protein 0.0211 0.0824 0.167
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.008 0.0251 0.0251
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.024 0.0232
Echinococcus multilocularis translational activator gcn1 0.0041 0.0081 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.0551 0.2311 0.6404
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0058 0.0156 0.1433
Schistosoma mansoni aldehyde dehydrogenase 0.0198 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0094 0.0312 0.0312
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.0609 0.1215
Brugia malayi beta-lactamase family protein 0.0077 0.024 0.0435
Plasmodium falciparum thioredoxin reductase 0.0199 0.0774 0.9027
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0206 0.2132
Schistosoma mansoni jumonji/arid domain-containing protein 0.0321 0.1303 0.1303
Trypanosoma brucei importin beta-1 subunit, putative 0.0217 0.0848 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.024 0.024
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0494 0.2061 0.9751
Echinococcus multilocularis apoptotic protease activating factor 1 0.0045 0.01 0.0091
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0169 0.0641 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0009 0.0009
Onchocerca volvulus Huntingtin homolog 0.0129 0.0465 0.1891
Schistosoma mansoni hypothetical protein 0.0045 0.01 0.01
Schistosoma mansoni importin beta-1 0.0217 0.0848 0.0848
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0506 0.2112 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0051 0.0124 0.019
Echinococcus granulosus lysine specific demethylase 5A 0.0321 0.1303 0.1295
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.008 0.0251 0.2663
Loa Loa (eye worm) hypothetical protein 0.0049 0.0115 0.0115
Brugia malayi hypothetical protein 0.0108 0.0373 0.0716
Trichomonas vaginalis glucosylceramidase, putative 0.0551 0.2311 0.6404
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.024 0.0885
Brugia malayi Probable ClpP-like protease 0.0169 0.0641 0.1284
Schistosoma mansoni ferritin 0.0037 0.0063 0.0063
Trypanosoma brucei metacaspase MCA3 0.0049 0.0115 0.0488
Schistosoma mansoni peptidase Clp (S14 family) 0.0169 0.0641 0.0641
Echinococcus multilocularis JmjC domain containing protein 4 0.0085 0.0274 0.0265
Echinococcus multilocularis lysosomal alpha glucosidase 0.0701 0.2965 0.2959
Loa Loa (eye worm) hypothetical protein 0.0077 0.024 0.024
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0069 0.0204 0.2445
Trichomonas vaginalis alpha-glucosidase, putative 0.0058 0.0156 0.0264
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0701 0.2965 0.2965
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0206 0.1674
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0455 0.189 0.892
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0069 0.0204 0.2087
Loa Loa (eye worm) hypothetical protein 0.0085 0.0274 0.0274
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.0609 0.06
Leishmania major hypothetical protein, conserved 0.0108 0.0373 0.4445
Echinococcus granulosus phd:f box containing protein 0.0085 0.0274 0.0265
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0058 0.0156 0.0264
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0115 0.0147
Mycobacterium tuberculosis Probable dehydrogenase 0.0455 0.189 0.892
Trichomonas vaginalis glucosylceramidase, putative 0.084 0.3573 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1699 0.7322 0.7319
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0077 0.0241
Mycobacterium ulcerans aldehyde dehydrogenase 0.0198 0.0767 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0656 0.2766 0.2766
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0115 0.0147
Plasmodium falciparum thioredoxin reductase 0.0069 0.0204 0.1604
Brugia malayi Melibiase family protein 0.0437 0.1812 0.3762
Schistosoma mansoni caspase-7 (C14 family) 0.0128 0.0463 0.0463
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0035 0.0026
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.008 0.0251 0.0242
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0169 0.0641 0.2838
Trypanosoma cruzi metacaspase, putative 0.0049 0.0115 0.0864
Trichomonas vaginalis esterase, putative 0.0077 0.024 0.0505
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0069 0.0204 0.0196
Schistosoma mansoni hypothetical protein 0.1261 0.5411 0.5411
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0058 0.0157 0.1625
Echinococcus multilocularis ferritin 0.0037 0.0063 0.0054
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0115 0.0106
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0058 0.0156 0.1433
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0506 0.2112 1
Brugia malayi hypothetical protein 0.0045 0.01 0.0138
Mycobacterium leprae Probable lipase LipE 0.0077 0.024 0.0885
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0069 0.0204 0.0204
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0041 0.0081 0.0057
Loa Loa (eye worm) hypothetical protein 0.0085 0.0274 0.0274
Leishmania major cathepsin L-like protease 0.007 0.0206 0.2132
Leishmania major trypanothione reductase 0.0199 0.0774 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0058 0.0156 0.0264
Leishmania major GTP-binding protein, putative 0.0136 0.0498 0.6184
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0087 0.0283 0.0274
Echinococcus granulosus apoptotic protease activating factor 1 0.0045 0.01 0.0091
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.009 0.0218
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0115 0.0293
Leishmania major glycosyl hydrolase-like protein 0.0058 0.0156 0.1433
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.024 0.2517
Trypanosoma cruzi metacaspase, putative 0.0049 0.0115 0.0864
Brugia malayi Thioredoxin reductase 0.0199 0.0774 0.1565
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0069 0.0204 0.1652
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0089 0.0293 0.3639
Plasmodium vivax metacaspase 1, putative 0.0049 0.0115 0.0983
Echinococcus multilocularis dna polymerase eta 0.0049 0.0116 0.0107
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0136 0.0498 0.6184
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0115 0.0147
Plasmodium falciparum JmjC domain-containing protein, putative 0.0085 0.0274 0.2505
Plasmodium falciparum ataxin-2 like protein, putative 0.0108 0.0373 0.3801
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0069 0.0204 0.2109
Schistosoma mansoni hypothetical protein 0.0038 0.0068 0.0068
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0069 0.0204 0.1604
Loa Loa (eye worm) hypothetical protein 0.0169 0.0641 0.0641
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0077 0.0343
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0111 0.0387 0.1598
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.024 0.0885
Toxoplasma gondii Alpha-galactosidase 0.0093 0.0308 0.1
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0656 0.2766 0.2759
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.008 0.0251 0.2749
Schistosoma mansoni hypothetical protein 0.1261 0.5411 0.5411
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0206 0.1674
Echinococcus multilocularis thioredoxin glutathione reductase 0.0199 0.0774 0.0765
Entamoeba histolytica Ran family GTPase 0.0136 0.0498 0.7113
Trypanosoma brucei metacaspase 5, putative 0.0049 0.0115 0.0488
Plasmodium vivax importin-beta 2, putative 0.0217 0.0848 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0111 0.0387 0.1598
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0085 0.0274 0.0875
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0069 0.0204 0.2008
Schistosoma mansoni ran 0.0136 0.0498 0.0498
Toxoplasma gondii HEAT repeat-containing protein 0.0217 0.0848 0.298
Brugia malayi Glycosyl hydrolases family 31 protein 0.0058 0.0156 0.0256
Echinococcus multilocularis geminin 0.1261 0.5411 0.5406
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0069 0.0204 0.071
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0156 0.0582 0.8524
Brugia malayi beta-lactamase 0.0077 0.024 0.0435
Schistosoma mansoni tar DNA-binding protein 0.007 0.021 0.021
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0049 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0045 0.01 0.01
Trichomonas vaginalis set domain proteins, putative 0.024 0.0951 0.253
Echinococcus granulosus ferritin 0.0037 0.0063 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0156 0.0582 0.7343
Brugia malayi hypothetical protein 0.0129 0.0465 0.0911
Loa Loa (eye worm) hypothetical protein 0.0049 0.0116 0.0116
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0069 0.0204 0.2109
Trypanosoma cruzi metacaspase, putative 0.0049 0.0115 0.0864
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.024 0.0885
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0058 0.0156 0.0264
Brugia malayi jmjC domain containing protein 0.0085 0.0274 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0115 0.0147
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0077 0.0343
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0128 0.0463 0.0455
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0136 0.0498 0.0498
Schistosoma mansoni hypothetical protein 0.2312 1 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0465 0.0465
Loa Loa (eye worm) hypothetical protein 0.0077 0.024 0.024
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0136 0.0498 0.5699
Onchocerca volvulus 0.0077 0.024 0.0904
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0206 0.1674
Plasmodium vivax glutathione reductase, putative 0.0199 0.0774 0.9083
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0128 0.0463 0.0455
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0136 0.0498 0.5437
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0202 0.0193
Toxoplasma gondii melibiase subfamily protein 0.0656 0.2766 1
Echinococcus granulosus caspase 0.0128 0.0463 0.0455
Mycobacterium ulcerans hypothetical protein 0.0077 0.024 0.2517
Loa Loa (eye worm) TAR-binding protein 0.007 0.021 0.021
Trypanosoma brucei metacaspase 0.0049 0.0115 0.0488
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0035 0.0035
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0072 0.0063
Toxoplasma gondii aldehyde dehydrogenase 0.0198 0.0767 0.2683
Brugia malayi Inositol-1 0.004 0.0077 0.009
Trichomonas vaginalis alpha-glucosidase, putative 0.0058 0.0156 0.0264
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.024 0.0885
Trichomonas vaginalis glucosylceramidase, putative 0.0551 0.2311 0.6404
Trichomonas vaginalis sucrase-isomaltase, putative 0.0156 0.0582 0.1479
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0145 0.0233
Trypanosoma brucei PAB1-binding protein , putative 0.0108 0.0373 0.3837
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0085 0.0274 0.3067
Trichomonas vaginalis glucosylceramidase, putative 0.0581 0.244 0.6773
Plasmodium falciparum glutathione reductase 0.0199 0.0774 0.9027
Loa Loa (eye worm) importin-beta domain-containing protein 0.0041 0.0081 0.0081
Schistosoma mansoni ferritin 0.0037 0.0063 0.0063
Echinococcus granulosus thioredoxin glutathione reductase 0.0199 0.0774 0.0765
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0115 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.084 0.3573 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0539 0.0539
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0455 0.189 0.892
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0539 0.053
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0118 0.0305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0539 0.0539
Echinococcus multilocularis zinc finger protein 0.0025 0.0012 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0115 0.0147
Brugia malayi RNA recognition motif domain containing protein 0.007 0.021 0.0371
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.008 0.0251 0.2663
Trichomonas vaginalis alpha-glucosidase, putative 0.0156 0.0582 0.1479
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0085 0.0274 0.0875
Echinococcus multilocularis caspase 8 0.0049 0.0115 0.0106
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0069 0.0204 0.2109
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.024 0.0505
Mycobacterium ulcerans lipase LipD 0.0077 0.024 0.2517
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0115 0.0147
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.024 0.2117
Trypanosoma cruzi PAB1-binding protein , putative 0.0108 0.0373 0.4445
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.024 0.2606
Echinococcus granulosus lysosomal alpha glucosidase 0.0701 0.2965 0.2959
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0115 0.0115
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0206 0.2132
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0048 0.0114 0.0105
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0115 0.0147
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0058 0.0157 0.0986
Loa Loa (eye worm) jmjC domain-containing protein 0.0085 0.0274 0.0274
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0077 0.004
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0437 0.1812 0.1812
Schistosoma mansoni apoferritin-2 0.0037 0.0063 0.0063
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0169 0.0641 0.2221
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.024 0.0885
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0111 0.0387 0.1598
Loa Loa (eye worm) hypothetical protein 0.1112 0.4758 0.4758
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0085 0.0274 0.3067
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.0116 0.0171
Loa Loa (eye worm) jmjC domain-containing protein 0.0085 0.0274 0.0274
Schistosoma mansoni inositol monophosphatase 0.004 0.0077 0.0077
Schistosoma mansoni ferritin 0.0037 0.0063 0.0063
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0136 0.0498 1
Plasmodium vivax ataxin-2 like protein, putative 0.0108 0.0373 0.4157
Mycobacterium tuberculosis Probable oxidoreductase 0.0506 0.2112 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0118 0.0109
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0145 0.0233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0539 0.0539
Trichomonas vaginalis glucosylceramidase, putative 0.0581 0.244 0.6773
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0539 0.053
Schistosoma mansoni alpha-glucosidase 0.0604 0.2538 0.2538
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0199 0.0774 0.3483
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0206 0.1674
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.024 0.024
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0069 0.0204 0.2109
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0069 0.0204 0.1652
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0115 0.0147
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0035 0.0035
Leishmania major DNA polymerase eta, putative 0.0049 0.0116 0.0878
Echinococcus multilocularis caspase 2 0.0094 0.0312 0.0303
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.003 0.0021
Loa Loa (eye worm) hypothetical protein 0.0038 0.0068 0.0068
Schistosoma mansoni jumonji domain containing protein 0.0319 0.1294 0.1294
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0058 0.0156 0.0531
Brugia malayi Bromodomain containing protein 0.0085 0.0274 0.0506
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0156 0.0582 0.1479
Trypanosoma cruzi trypanothione reductase, putative 0.0069 0.0204 0.2109
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0069 0.0204 0.0622
Schistosoma mansoni phd/f-box containing protein 0.0085 0.0274 0.0274
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0068 0.007
Trichomonas vaginalis alpha-glucosidase, putative 0.0156 0.0582 0.1479
Plasmodium vivax JmjC domain containing protein 0.0085 0.0274 0.2936
Leishmania major alpha glucosidase II subunit, putative 0.0156 0.0582 0.7343
Trypanosoma brucei glucosidase, putative 0.0156 0.0582 0.6548
Onchocerca volvulus 0.024 0.0951 0.4026
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.008 0.0251 0.0242
Trichomonas vaginalis glucosylceramidase, putative 0.0551 0.2311 0.6404
Schistosoma mansoni ran 0.0136 0.0498 0.0498
Echinococcus granulosus tar DNA binding protein 0.007 0.021 0.0201
Plasmodium vivax thioredoxin reductase, putative 0.0199 0.0774 0.9083
Loa Loa (eye worm) hypothetical protein 0.0048 0.0112 0.0112
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.008 0.0251 0.0935
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.024 0.0505
Schistosoma mansoni ferritin light chain 0.0037 0.0063 0.0063
Mycobacterium tuberculosis Conserved protein 0.0077 0.024 0.0885
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0115 0.0147
Loa Loa (eye worm) hypothetical protein 0.0108 0.0373 0.0373
Mycobacterium tuberculosis Conserved protein 0.0077 0.024 0.0885
Loa Loa (eye worm) hypothetical protein 0.0077 0.024 0.024
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0274 0.0274
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0058 0.0157 0.0479
Loa Loa (eye worm) jmjC domain-containing protein 0.0085 0.0274 0.0274
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0319 0.1294 0.1286
Brugia malayi Bromodomain containing protein 0.0045 0.01 0.0139
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0115 0.0293
Loa Loa (eye worm) hypothetical protein 0.0058 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0077 0.024 0.024
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0069 0.0204 0.0359
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0169 0.0641 1
Brugia malayi RNA binding protein 0.007 0.021 0.0371
Toxoplasma gondii hypothetical protein 0.0058 0.0157 0.0448
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0455 0.189 0.892
Onchocerca volvulus 0.0045 0.01 0.0287
Leishmania major hypothetical protein, conserved 0.0041 0.0081 0.0404
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0206 0.2132
Trypanosoma brucei trypanothione reductase 0.0199 0.0774 0.9033
Treponema pallidum NADH oxidase 0.0069 0.0204 0.2445
Plasmodium falciparum importin beta, putative 0.0217 0.0848 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0198 0.0767 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0206 0.1674
Echinococcus granulosus peptidase Clp S14 family 0.0111 0.0387 0.0378
Brugia malayi jmjC domain containing protein 0.0319 0.1294 0.2666
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0206 0.1674
Schistosoma mansoni caspase-3 (C14 family) 0.0128 0.0463 0.0463
Trichomonas vaginalis hypothetical protein 0.0041 0.0081 0.0052
Loa Loa (eye worm) inositol-1 0.004 0.0077 0.0077
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0656 0.2766 0.2766
Leishmania major importin beta-1 subunit, putative 0.0176 0.067 0.8555
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0437 0.1812 0.1812
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0136 0.0498 0.1698
Trichomonas vaginalis mercuric reductase, putative 0.0069 0.0204 0.0403
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0118 0.0305
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.008 0.0251 0.0457
Trypanosoma cruzi metacaspase 5, putative 0.0049 0.0115 0.0864
Trypanosoma brucei glycosyl hydrolase-like protein 0.0058 0.0156 0.1019
Loa Loa (eye worm) glutathione reductase 0.0199 0.0774 0.0774
Echinococcus granulosus lysine specific demethylase 6a 0.0085 0.0274 0.0265
Schistosoma mansoni tar DNA-binding protein 0.007 0.021 0.021
Leishmania major metacaspase, putative 0.0049 0.0115 0.0864
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0217 0.0848 0.0848
Onchocerca volvulus 0.0077 0.024 0.0904
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.024 0.2517
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0169 0.0641 0.8211
Plasmodium falciparum metacaspase-like protein 0.0049 0.0115 0.0433
Leishmania major cathepsin L-like protease 0.007 0.0206 0.2132
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.0609 0.0609
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0656 0.2766 0.2759
Entamoeba histolytica hypothetical protein 0.0176 0.067 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0206 0.1674
Leishmania major cathepsin L-like protease 0.007 0.0206 0.2132
Mycobacterium ulcerans beta-lactamase 0.0077 0.024 0.2517
Schistosoma mansoni bromodomain containing protein 0.0072 0.0218 0.0218
Trichomonas vaginalis maltase-glucoamylase, putative 0.0058 0.0156 0.0264
Brugia malayi jmjC domain containing protein 0.0085 0.0274 0.0506
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.084 0.3573 0.749
Toxoplasma gondii NADPH-glutathione reductase 0.0069 0.0204 0.0622
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0087 0.0283 0.0274
Toxoplasma gondii thioredoxin reductase 0.0199 0.0774 0.2707
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0069 0.0204 0.2087
Schistosoma mansoni tar DNA-binding protein 0.007 0.021 0.021
Schistosoma mansoni jumonji/arid domain-containing protein 0.0321 0.1303 0.1303
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0077 0.004
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0206 0.2132
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0115 0.0147
Plasmodium falciparum glutathione reductase 0.0069 0.0204 0.1604
Trypanosoma cruzi metacaspase, putative 0.0049 0.0115 0.0864
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0156 0.0582 0.1479
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0169 0.0641 0.2221
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0115 0.0147
Mycobacterium tuberculosis Conserved protein 0.0077 0.024 0.0885
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0118 0.0157
Echinococcus granulosus JmjC domain containing protein 4 0.0085 0.0274 0.0265
Trichomonas vaginalis glucosylceramidase, putative 0.0551 0.2311 0.6404
Schistosoma mansoni protein phosphatase 2C 0.0085 0.0274 0.0274
Brugia malayi jmjC domain containing protein 0.0321 0.1303 0.2685
Echinococcus multilocularis importin 5 0.0041 0.0081 0.0072
Schistosoma mansoni apoferritin-2 0.0037 0.0063 0.0063
Trichomonas vaginalis alpha-glucosidase, putative 0.0058 0.0156 0.0264
Echinococcus granulosus translational activator gcn1 0.0041 0.0081 0.0072
Schistosoma mansoni phosphatidylserine receptor 0.0085 0.0274 0.0274
Echinococcus multilocularis jumonji domain containing 1A 0.0085 0.0274 0.0265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0206 0.1674
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0069 0.0204 0.1604
Schistosoma mansoni DNA polymerase eta 0.0049 0.0116 0.0116
Schistosoma mansoni ferritin light chain 0.0037 0.0063 0.0063
Trichomonas vaginalis glucosylceramidase, putative 0.084 0.3573 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0041 0.0084 0.0084
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.024 0.0435
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.024 0.2606
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0069 0.0204 0.2109
Loa Loa (eye worm) hypothetical protein 0.0089 0.0293 0.0293
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0048 0.0114 0.0105
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0202 0.0193
Mycobacterium tuberculosis Probable reductase 0.0455 0.189 0.892
Brugia malayi TAR-binding protein 0.007 0.021 0.0371
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0455 0.189 0.892
Echinococcus multilocularis lysine specific demethylase 6a 0.0085 0.0274 0.0265
Brugia malayi Glycosyl hydrolases family 31 protein 0.0701 0.2965 0.6204
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0159 0.0159
Toxoplasma gondii HEAT repeat-containing protein 0.0041 0.0081 0.0171
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0041 0.0081 0.0057
Brugia malayi RNA, U transporter 1 0.0616 0.2592 0.5415
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0656 0.2766 0.2766
Toxoplasma gondii LsmAD domain-containing protein 0.0108 0.0373 0.1239
Loa Loa (eye worm) thioredoxin reductase 0.0199 0.0774 0.0774
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0089 0.0293 0.3639
Echinococcus multilocularis expressed protein 0.0037 0.0063 0.0054
Trichomonas vaginalis alpha-glucosidase, putative 0.0156 0.0582 0.1479
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0037 0.0063 0.0021
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0169 0.0641 0.7299
Trichomonas vaginalis alpha-glucosidase, putative 0.0156 0.0582 0.1479
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.0539 0.1067
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0145 0.0145
Echinococcus granulosus importin subunit beta 1 0.0217 0.0848 0.084
Onchocerca volvulus 0.0406 0.1674 0.7201
Echinococcus granulosus importin 5 0.0041 0.0081 0.0072
Plasmodium vivax hypothetical protein, conserved 0.0077 0.024 0.2527
Brugia malayi Importin beta-1 subunit 0.0217 0.0848 0.1723
Schistosoma mansoni inositol monophosphatase 0.004 0.0077 0.0077
Trypanosoma brucei importin beta-1 subunit, putative 0.0217 0.0848 1
Onchocerca volvulus 0.0077 0.024 0.0904
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.084 0.3573 0.3573
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0156 0.0582 0.0582
Loa Loa (eye worm) hypothetical protein 0.0077 0.024 0.024
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.024 0.0505
Echinococcus multilocularis caspase 3 0.008 0.0251 0.0242
Onchocerca volvulus Huntingtin homolog 0.0129 0.0465 0.1891
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0176 0.067 0.1728
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0156 0.0582 0.2004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0115 0.0147
Trypanosoma cruzi PAB1-binding protein , putative 0.0108 0.0373 0.4445
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0118 0.0157
Schistosoma mansoni tar DNA-binding protein 0.007 0.021 0.021
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0051 0.0124 0.019
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0058 0.0156 0.1327
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0118 0.1025
Entamoeba histolytica HEAT repeat domain containing protein 0.0041 0.0081 0.0075
Echinococcus multilocularis caspase 0.0128 0.0463 0.0455
Echinococcus granulosus dna polymerase eta 0.0049 0.0116 0.0107
Schistosoma mansoni alpha glucosidase 0.0156 0.0582 0.0582
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0115 0.0147
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0136 0.0498 0.0982
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0093 0.0308 0.0308
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0069 0.0204 0.1652
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0136 0.0498 0.5463
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.024 0.024
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0069 0.0204 0.0196
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0077 0.0343
Echinococcus multilocularis muscleblind protein 1 0.1112 0.4758 0.4753
Brugia malayi beta-lactamase family protein 0.0077 0.024 0.0435
Echinococcus multilocularis lysosomal alpha glucosidase 0.0701 0.2965 0.2959
Echinococcus multilocularis neutral alpha glucosidase AB 0.0156 0.0582 0.0574
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.024 0.0505
Leishmania major hypothetical protein, conserved 0.0085 0.0274 0.3067
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0069 0.0204 0.2008
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0169 0.0641 1
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0115 0.0147
Trichomonas vaginalis glucosylceramidase, putative 0.0551 0.2311 0.6404
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0156 0.0582 0.8524
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0198 0.0767 0.3451
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0069 0.0204 0.2109
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0077 0.0155
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0069 0.0204 0.2109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0539 0.053
Trichomonas vaginalis glucosylceramidase, putative 0.084 0.3573 1
Trichomonas vaginalis glucosylceramidase, putative 0.084 0.3573 1
Brugia malayi Cell death protein 3 precursor 0.0094 0.0312 0.0588
Trypanosoma cruzi hypothetical protein, conserved 0.0156 0.0582 0.7343
Echinococcus multilocularis importin subunit beta 1 0.0217 0.0848 0.084
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0455 0.189 0.892
Plasmodium vivax transportin, putative 0.0041 0.0081 0.0575
Echinococcus multilocularis muscleblind protein 0.1112 0.4758 0.4753
Brugia malayi kap beta 3 protein 0.0041 0.0081 0.0099
Trypanosoma brucei Metacaspase-4 0.0049 0.0115 0.0488
Onchocerca volvulus Cell death protein 3 homolog 0.0094 0.0312 0.1219
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0169 0.0641 0.7455
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.0539 0.0539
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0656 0.2766 0.2766
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0085 0.0274 0.0274
Plasmodium falciparum ataxin-2 like protein, putative 0.0108 0.0373 0.3801
Trichomonas vaginalis ran, putative 0.0136 0.0498 0.124
Brugia malayi glutathione reductase 0.0199 0.0774 0.1565
Schistosoma mansoni tar DNA-binding protein 0.007 0.021 0.021
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0058 0.0157 0.1504
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0141 0.1232
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.024 0.0885
Schistosoma mansoni caspase-7 (C14 family) 0.0094 0.0312 0.0312
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0069 0.0204 0.2109
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0136 0.0498 0.049
Trypanosoma brucei DNA polymerase eta, putative 0.0049 0.0116 0.05
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0115 0.0147
Giardia lamblia NADH oxidase lateral transfer candidate 0.0069 0.0204 0.2804
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0198 0.0767 0.991
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0437 0.1812 0.4982
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0069 0.0204 0.2109
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0539 0.053
Brugia malayi jmjC domain containing protein 0.0085 0.0274 0.0506
Echinococcus multilocularis phd:f box containing protein 0.0085 0.0274 0.0265
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0069 0.0204 0.2109
Echinococcus granulosus neutral alpha glucosidase AB 0.0156 0.0582 0.0574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0206 0.1674
Echinococcus granulosus zinc finger protein 0.0025 0.0012 0.0003
Onchocerca volvulus Glucosylceramidase homolog 0.0551 0.2311 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.018 0.1767
Toxoplasma gondii HEAT repeat-containing protein 0.0041 0.0081 0.0171
Trypanosoma cruzi trypanothione reductase, putative 0.0199 0.0774 1
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.024 0.0505
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0069 0.0204 0.2109
Schistosoma mansoni importin-beta 2 0.0041 0.0081 0.0081
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0319 0.1294 0.1286
Loa Loa (eye worm) hypothetical protein 0.005 0.0121 0.0121
Trypanosoma brucei metacaspase MCA2 0.0049 0.0115 0.0488
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.024 0.0885
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0115 0.0115
Echinococcus granulosus caspase 8 0.0049 0.0115 0.0106
Toxoplasma gondii ABC1 family protein 0.0077 0.024 0.0753
Echinococcus granulosus GTP binding nuclear protein Ran 0.0136 0.0498 0.049
Mycobacterium leprae conserved hypothetical protein 0.0077 0.024 0.0885
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0506 0.2112 1
Trichomonas vaginalis importin beta-1, putative 0.0176 0.067 0.1728
Leishmania major hypothetical protein, conserved 0.0077 0.024 0.2606
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0115 0.0293
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0176 0.067 0.1728
Echinococcus granulosus expressed protein 0.0037 0.0063 0.0054
Loa Loa (eye worm) hypothetical protein 0.0437 0.1812 0.1812
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.2312 1 1
Schistosoma mansoni ferritin 0.0037 0.0063 0.0063
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0072 0.0063
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0116 0.0878
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0136 0.0498 0.6184
Echinococcus granulosus muscleblind protein 0.1112 0.4758 0.4753
Loa Loa (eye worm) kap beta 3 protein 0.0041 0.0081 0.0081
Echinococcus granulosus caspase 2 0.0094 0.0312 0.0303
Loa Loa (eye worm) hypothetical protein 0.0076 0.0237 0.0237
Brugia malayi hypothetical protein 0.007 0.0206 0.0363
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0049 0.0115 0.0169
Plasmodium falciparum metacaspase 1 0.0049 0.0115 0.0433
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0003 0.0003
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0656 0.2766 0.2759
Trichomonas vaginalis glucosylceramidase, putative 0.0551 0.2311 0.6404
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.0578 0.057
Echinococcus multilocularis lysine specific demethylase 5A 0.0319 0.1294 0.1286
Echinococcus granulosus jumonji domain containing 1A 0.0085 0.0274 0.0265
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0069 0.0204 0.1652
Loa Loa (eye worm) hypothetical protein 0.1112 0.4758 0.4758
Trichomonas vaginalis glutathione reductase, putative 0.0069 0.0204 0.0403
Echinococcus granulosus transportin 1 0.0041 0.0081 0.0072
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0115 0.0983
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0037 0.0063 0.0021
Schistosoma mansoni alpha-glucosidase 0.0604 0.2538 0.2538
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0077 0.0198
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0198 0.0767 0.0759
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0169 0.0641 0.0633
Loa Loa (eye worm) hypothetical protein 0.0049 0.0115 0.0115
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0169 0.0641 0.8211
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0077 0.0068
Mycobacterium ulcerans aldehyde dehydrogenase 0.0198 0.0767 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.0824 0.0824
Echinococcus multilocularis snurportin 1 0.2312 1 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0176 0.067 0.8555
Echinococcus multilocularis peptidase Clp (S14 family) 0.0111 0.0387 0.0378
Brugia malayi jmjC domain containing protein 0.0085 0.0274 0.0506
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0077 0.0068
Loa Loa (eye worm) hypothetical protein 0.0129 0.0465 0.0465
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0052 0.0064
Loa Loa (eye worm) beta-lactamase 0.0077 0.024 0.024
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0198 0.0767 0.0759
Loa Loa (eye worm) RNA binding protein 0.007 0.021 0.021
Echinococcus multilocularis tar DNA binding protein 0.007 0.021 0.0201
Brugia malayi PHD-finger family protein 0.0031 0.0037 0.0005
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0169 0.0641 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0206 0.1674
Trichomonas vaginalis glucosylceramidase, putative 0.084 0.3573 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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