Detailed information for compound 793031

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.503 | Formula: C22H24N2O2S
  • H donors: 1 H acceptors: 2 LogP: 4.62 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNC(=O)c1ccc2c(c1)n(C)c(=O)c(=Cc1ccccc1C)s2
  • InChi: 1S/C22H24N2O2S/c1-4-5-12-23-21(25)17-10-11-19-18(13-17)24(3)22(26)20(27-19)14-16-9-7-6-8-15(16)2/h6-11,13-14H,4-5,12H2,1-3H3,(H,23,25)/b20-14-
  • InChiKey: SPTLWPZKRCKUAW-ZHZULCJRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0288 0.058
Schistosoma mansoni notch 0.0043 0.039 0.0785
Leishmania major cathepsin L-like protease 0.0071 0.0718 0.3659
Echinococcus granulosus neurogenic locus notch protein 0.0043 0.039 0.0785
Giardia lamblia Cathepsin L precursor 0.0034 0.0288 0.1533
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0134 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0034 0.0288 0.1661
Brugia malayi Papain family cysteine protease containing protein 0.0071 0.0718 0.1446
Brugia malayi Cadherin domain containing protein 0.0043 0.039 0.0785
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0199 0.305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0288 0.1661
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0718 0.4138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Loa Loa (eye worm) hypothetical protein 0.0132 0.1409 0.2837
Giardia lamblia Cysteine protease 0.0034 0.0288 0.1533
Echinococcus multilocularis peroxidasin 0.0132 0.1409 0.1409
Onchocerca volvulus 0.002 0.0134 0.0781
Onchocerca volvulus Chorion peroxidase homolog 0.0132 0.1409 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0002 0.0004
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0034 0.0288 0.1533
Entamoeba histolytica cysteine protease, putative 0.0071 0.0718 0.6357
Brugia malayi EGF-like domain containing protein 0.0043 0.039 0.0785
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.016 0.1937
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0034 0.0288 0.3787
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0718 0.4138
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0339 0.0682
Schistosoma mansoni slit 0.0043 0.039 0.0785
Plasmodium vivax vivapain-3 0.0071 0.0718 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0592 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.113 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0692 0.1394
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0026 0.0151
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0199 0.1761
Echinococcus multilocularis protein dispatched 1 0.0053 0.0504 0.0504
Toxoplasma gondii cathepsin CPC2 0.0034 0.0288 0.1661
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Brugia malayi Cathepsin L-like precursor 0.0071 0.0718 0.1446
Brugia malayi Animal haem peroxidase family protein 0.0132 0.1409 0.2837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0718 0.4138
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0718 0.4138
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0199 1
Brugia malayi Animal haem peroxidase family protein 0.0132 0.1409 0.2837
Onchocerca volvulus 0.0132 0.1409 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0131 1
Echinococcus multilocularis slit 2 protein 0.0043 0.039 0.039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0718 0.4138
Schistosoma mansoni Smad4 0.0009 0.0002 0.0004
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.113 0.113
Toxoplasma gondii exonuclease III APE 0.002 0.0131 0.0755
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0718 0.4138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0288 0.058
Brugia malayi cathepsin L-like precursor 0.0034 0.0288 0.058
Brugia malayi Cathepsin L-like precursor 0.0071 0.0718 0.1446
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0034 0.0288 0.1661
Echinococcus granulosus expressed conserved protein 0.0101 0.1055 0.2125
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0199 0.305
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0199 0.04
Onchocerca volvulus Peroxidasin homolog 0.0132 0.1409 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0034 0.0288 0.058
Echinococcus granulosus Protein kinase C brain isozyme 0.0014 0.0068 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0034 0.0288 0.1661
Brugia malayi Doublecortin family protein 0.002 0.0134 0.027
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0131 0.0264
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.113 0.2274
Echinococcus multilocularis protein kinase c iota type 0.0096 0.0997 0.0997
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0131 0.0131
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0034 0.0288 0.058
Loa Loa (eye worm) fibroinase 0.0071 0.0718 0.1446
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0026 0.0053
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0071 0.0718 0.14
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0034 0.0288 0.3787
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0288 0.1661
Entamoeba histolytica cysteine proteinase 2 0.0071 0.0718 0.6357
Plasmodium falciparum cysteine proteinase falcipain 1 0.0071 0.0718 1
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0288 0.058
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.016 0.0924
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Entamoeba histolytica cysteine protease, putative 0.0034 0.0288 0.2552
Giardia lamblia Cathepsin L-like protease 0.0034 0.0288 0.1533
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0034 0.0288 0.1533
Giardia lamblia Cathepsin B precursor 0.016 0.1735 1
Loa Loa (eye worm) animal heme peroxidase 0.0132 0.1409 0.2837
Echinococcus granulosus cysteine protease 0.0071 0.0718 0.1446
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0333 0.0622
Echinococcus granulosus importin subunit beta 1 0.003 0.0252 0.0508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0718 0.4138
Toxoplasma gondii cathepsin CPC1 0.0034 0.0288 0.1661
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0071 0.0718 0.4138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0718 0.4138
Echinococcus granulosus protein kinase c iota type 0.0096 0.0997 0.2007
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0034 0.0288 0.053
Loa Loa (eye worm) hypothetical protein 0.0132 0.1409 0.2837
Schistosoma mansoni peroxidasin 0.0132 0.1409 0.2837
Echinococcus multilocularis cysteine protease 0.0071 0.0718 0.0718
Entamoeba histolytica cysteine protease, putative 0.0071 0.0718 0.6357
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Brugia malayi Importin beta-1 subunit 0.003 0.0252 0.0508
Echinococcus granulosus cathepsin b 0.0443 0.4966 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0288 0.058
Brugia malayi cathepsin L-like cysteine proteinase 0.0034 0.0288 0.058
Loa Loa (eye worm) hypothetical protein 0.0132 0.1409 0.2837
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Leishmania major cathepsin L-like protease 0.0071 0.0718 0.3659
Echinococcus multilocularis expressed conserved protein 0.0101 0.1055 0.1055
Echinococcus granulosus snurportin 1 0.0326 0.3625 0.73
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0026 0.0151
Entamoeba histolytica cysteine protease, putative 0.0071 0.0718 0.6357
Plasmodium vivax importin-beta 2, putative 0.003 0.0252 0.3268
Loa Loa (eye worm) hypothetical protein 0.0132 0.1409 0.2837
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.027
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.1148 0.2313
Brugia malayi cathepsin L precursor 0.0034 0.0288 0.058
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0002 0.0004
Giardia lamblia Hypothetical protein 0.0034 0.0288 0.1533
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0288 0.1661
Plasmodium falciparum cysteine proteinase falcipain 3 0.0071 0.0718 1
Brugia malayi Calcium binding EGF domain containing protein 0.0043 0.039 0.0785
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0002 0.0002
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0592 0.1192
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0692 0.0692
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1347 0.2712
Schistosoma mansoni hypothetical protein 0.0043 0.039 0.0785
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0068 0.0137
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.016 0.0271
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0199 1
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0026 0.0053
Echinococcus multilocularis cysteine protease 0.0071 0.0718 0.0718
Schistosoma mansoni atypical protein kinase C 0.0102 0.1065 0.2144
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0121 0.1283 0.1283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.016 0.1735 0.3494
Loa Loa (eye worm) hypothetical protein 0.0034 0.0288 0.058
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0718 0.14
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0692 0.1394
Onchocerca volvulus 0.0071 0.0718 0.5003
Brugia malayi EGF-like domain containing protein 0.0043 0.039 0.0785
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0026 0.0151
Giardia lamblia Cathepsin B precursor 0.0034 0.0288 0.1533
Plasmodium vivax serine-repeat antigen (SERA) 0.0034 0.0288 0.3787
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0034 0.0288 0.3787
Entamoeba histolytica cysteine proteinase 1, putative 0.0071 0.0718 0.6357
Onchocerca volvulus Peroxidase homolog 0.0132 0.1409 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0131 0.0613
Echinococcus granulosus slit 2 protein 0.0043 0.039 0.0785
Echinococcus multilocularis cathepsin L cysteine protease 0.0071 0.0718 0.0718
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.016 0.0784
Schistosoma mansoni ran 0.0022 0.016 0.0323
Echinococcus granulosus neurogenic locus notch protein 0.0043 0.039 0.0785
Entamoeba histolytica cysteine protease, putative 0.0071 0.0718 0.6357
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0026 0.0151
Leishmania major cathepsin L-like protease 0.0071 0.0718 0.3659
Plasmodium falciparum importin beta, putative 0.003 0.0252 0.3268
Echinococcus granulosus protein kinase c epsilon type 0.0014 0.0068 0.0137
Loa Loa (eye worm) hypothetical protein 0.0026 0.0199 0.04
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0131 0.0264
Onchocerca volvulus Peroxidasin homolog 0.0132 0.1409 1
Entamoeba histolytica cysteine protease, putative 0.0071 0.0718 0.6357
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0131 0.116
Loa Loa (eye worm) hypothetical protein 0.0056 0.0548 0.1104
Schistosoma mansoni importin beta-1 0.003 0.0252 0.0508
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.016 0.1735 1
Echinococcus granulosus tar DNA binding protein 0.0069 0.0692 0.1394
Giardia lamblia Cathepsin L-like protease 0.0034 0.0288 0.1533
Onchocerca volvulus 0.0026 0.0199 0.1248
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0443 0.4966 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0592 0.2875
Entamoeba histolytica hypothetical protein 0.0038 0.0339 0.2998
Mycobacterium ulcerans hypothetical protein 0.0026 0.0199 0.305
Entamoeba histolytica Ran family GTPase 0.0022 0.016 0.1419
Onchocerca volvulus Peroxidase homolog 0.0132 0.1409 1
Echinococcus multilocularis protein jagged 2 0.0043 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Entamoeba histolytica cysteine proteinase, putative 0.0071 0.0718 0.6357
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0071 0.0718 0.1446
Entamoeba histolytica hypothetical protein 0.0038 0.0339 0.2998
Giardia lamblia Hypothetical protein 0.0034 0.0288 0.1533
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0124 0.1417
Echinococcus granulosus cathepsin l1 0.0034 0.0288 0.058
Entamoeba histolytica hypothetical protein 0.0038 0.0339 0.2998
Echinococcus granulosus delta-like protein 1 0.0043 0.039 0.0785
Schistosoma mansoni patched 1 0.0046 0.043 0.0865
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0034 0.0288 0.3787
Entamoeba histolytica cysteine protease, putative 0.0071 0.0718 0.6357
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0014 0.0068 0.0068
Brugia malayi Papain family cysteine protease containing protein 0.0071 0.0718 0.1446
Onchocerca volvulus 0.0132 0.1409 1
Leishmania major cysteine peptidase A (CPA) 0.0071 0.0718 0.3659
Echinococcus multilocularis Smad4 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0288 0.1661
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0068 0.0137
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0034 0.0288 0.1533
Brugia malayi EGF-like domain containing protein 0.0043 0.039 0.0785
Onchocerca volvulus 0.0132 0.1409 1
Brugia malayi Peroxidasin 0.0132 0.1409 0.2837
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0002 0.0004
Brugia malayi MH2 domain containing protein 0.0126 0.1347 0.2712
Brugia malayi fibroinase precursor 0.0034 0.0288 0.058
Entamoeba histolytica cysteine proteinase, putative 0.0071 0.0718 0.6357
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0034 0.0288 0.1661
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0053
Loa Loa (eye worm) hypothetical protein 0.0132 0.1409 0.2837
Onchocerca volvulus 0.0034 0.0288 0.1895
Echinococcus granulosus cathepsin l1 0.0071 0.0718 0.1446
Echinococcus granulosus Niemann Pick C1 protein 0.0153 0.1656 0.3334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0034 0.0288 0.3787
Loa Loa (eye worm) hypothetical protein 0.0034 0.0288 0.058
Onchocerca volvulus 0.0071 0.0718 0.5003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0718 0.4138
Onchocerca volvulus Cathepsin F homolog 0.0071 0.0718 0.5003
Echinococcus multilocularis neurogenic locus protein delta 0.0043 0.039 0.039
Plasmodium falciparum serine repeat antigen 8 0.0034 0.0288 0.3787
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0026 0.0151
Brugia malayi EGF-like domain containing protein 0.0043 0.039 0.0785
Brugia malayi RNA, U transporter 1 0.0087 0.0895 0.1802
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0053
Echinococcus granulosus peroxidasin 0.0132 0.1409 0.2837
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0034 0.0288 0.1533
Loa Loa (eye worm) hypothetical protein 0.0071 0.0718 0.1446
Loa Loa (eye worm) blistered cuticle protein 3 0.0132 0.1409 0.2837
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.016 0.0323
Brugia malayi Calcium binding EGF domain containing protein 0.0043 0.039 0.0785
Entamoeba histolytica cysteine protease, putative 0.0034 0.0288 0.2552
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Onchocerca volvulus 0.0071 0.0718 0.5003
Plasmodium falciparum serine repeat antigen 3 0.0034 0.0288 0.3787
Echinococcus multilocularis cathepsin L 0.0071 0.0718 0.0718
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0199 0.305
Brugia malayi Cathepsin L-like precursor 0.0034 0.0288 0.058
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.043 0.043
Brugia malayi protein kinase C3,putative 0.0087 0.0903 0.1817
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.025
Toxoplasma gondii cathepsin B 0.016 0.1735 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0002 0.0002
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0034 0.0288 0.3787
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0718 0.4138
Entamoeba histolytica cysteine proteinase, putative 0.0071 0.0718 0.6357
Echinococcus multilocularis snurportin 1 0.0326 0.3625 0.3625
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.016 0.1735 1
Schistosoma mansoni laminin gamma-3 chain 0.0043 0.039 0.0785
Entamoeba histolytica cysteine protease, putative 0.0034 0.0288 0.2552
Toxoplasma gondii EGF family domain-containing protein 0.0043 0.039 0.2248
Schistosoma mansoni topbp1 0.0011 0.0026 0.0053
Brugia malayi hypothetical protein 0.0132 0.1409 0.2837
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0718 0.14
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0718 0.4138
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0002 0.0004
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0043 0.039 0.2631
Loa Loa (eye worm) hypothetical protein 0.0026 0.0199 0.04
Echinococcus multilocularis cathepsin b 0.0443 0.4966 0.4966
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.016 0.0323
Echinococcus granulosus Protein patched homolog 1 0.0046 0.043 0.0865
Schistosoma mansoni cathepsin F (C01 family) 0.0071 0.0718 0.1446
Loa Loa (eye worm) hypothetical protein 0.0034 0.0288 0.058
Schistosoma mansoni hypothetical protein 0.0044 0.0411 0.0827
Echinococcus multilocularis fibropellin Ia 0.0043 0.039 0.039
Echinococcus granulosus cathepsin L cysteine proteinase 0.0071 0.0718 0.1446
Brugia malayi Smad1 0.0009 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0288 0.1661
Schistosoma mansoni hypothetical protein 0.0038 0.0339 0.0682
Giardia lamblia High cysteine protein 0.0043 0.039 0.2129
Plasmodium falciparum serine repeat antigen 6 0.0034 0.0288 0.3787
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0034 0.0288 0.3787
Schistosoma mansoni hypothetical protein 0.002 0.0134 0.027
Onchocerca volvulus Dual oxidase homolog 0.0132 0.1409 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0339 0.0682
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0288 0.1661
Trypanosoma brucei cysteine peptidase C (CPC) 0.016 0.1735 1
Entamoeba histolytica hypothetical protein 0.0025 0.0186 0.165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0718 0.4138
Loa Loa (eye worm) hypothetical protein 0.0034 0.0288 0.058
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0093 0.0971 0.1955
Brugia malayi hypothetical protein 0.0011 0.0026 0.0053
Echinococcus granulosus RUN 0.002 0.0134 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0288 0.1661
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0718 0.4138
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0034 0.0288 0.058
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.0718 0.14
Echinococcus multilocularis nibrin 0.0011 0.0026 0.0026
Entamoeba histolytica cysteine proteinase, putative 0.0071 0.0718 0.6357
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Loa Loa (eye worm) hypothetical protein 0.0107 0.113 0.2274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0718 0.4138
Echinococcus granulosus protein jagged 1 0.0043 0.039 0.0785
Schistosoma mansoni hypothetical protein 0.0326 0.3625 0.73
Brugia malayi Cathepsin L-like precursor 0.0071 0.0718 0.1446
Entamoeba histolytica cysteine protease, putative 0.0034 0.0288 0.2552
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0288 0.1895
Loa Loa (eye worm) hypothetical protein 0.0034 0.0288 0.058
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.016 0.1937
Trypanosoma cruzi major cysteine proteinase, putative 0.0034 0.0288 0.053
Schistosoma mansoni cathepsin C 0.0034 0.0288 0.058
Echinococcus multilocularis neurogenic locus protein delta 0.0043 0.039 0.039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0199 0.0423
Loa Loa (eye worm) notch protein 0.0043 0.039 0.0785
Echinococcus granulosus protein jagged 2 0.0043 0.039 0.0785
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0026 0.0151
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0071 0.0718 1
Brugia malayi Animal haem peroxidase family protein 0.0132 0.1409 0.2837
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0718 0.4138
Brugia malayi cathepsin F-like cysteine proteinase 0.0034 0.0288 0.058
Schistosoma mansoni lipoxygenase 0.0121 0.1283 0.2583
Loa Loa (eye worm) hypothetical protein 0.0034 0.0288 0.058
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0026 0.0151
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0718 0.4138
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0288 0.058
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0288 0.1661
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.025
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0199 0.305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0034 0.0288 0.1661
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.043 0.0865
Loa Loa (eye worm) hypothetical protein 0.003 0.0252 0.0508
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0252 0.1454
Onchocerca volvulus 0.0043 0.039 0.2631
Plasmodium vivax vivapain-2 0.0071 0.0718 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0034 0.0288 0.1661
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0252 0.1454
Echinococcus multilocularis protein kinase c epsilon type 0.0014 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0043 0.039 0.0785
Echinococcus multilocularis cathepsin b 0.0443 0.4966 0.4966
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0026 0.0151
Brugia malayi Cathepsin L-like precursor 0.0038 0.0333 0.0671
Entamoeba histolytica cysteine protease, putative 0.0071 0.0718 0.6357
Echinococcus multilocularis cathepsin L cysteine protease 0.0071 0.0718 0.0718
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0131 0.1852
Brugia malayi Muscle positioning protein 4 0.0043 0.039 0.0785
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0026 0.0151
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0692 0.1394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0026 0.0151
Brugia malayi Cathepsin L-like precursor 0.0071 0.0718 0.1446
Loa Loa (eye worm) hypothetical protein 0.0034 0.0288 0.058
Onchocerca volvulus 0.0071 0.0718 0.5003
Onchocerca volvulus 0.0071 0.0718 0.5003
Schistosoma mansoni smad1 5 8 and 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Plasmodium vivax unspecified product 0.0038 0.0333 0.444
Giardia lamblia Cathepsin L precursor 0.0034 0.0288 0.1533
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0034 0.0288 0.3787
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0131 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0288 0.058
Brugia malayi Animal haem peroxidase family protein 0.0132 0.1409 0.2837
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0326 0.3625 0.73
Entamoeba histolytica cysteine protease, putative 0.0071 0.0718 0.6357
Brugia malayi cathepsin Z-like cysteine proteinase 0.0034 0.0288 0.058
Trichomonas vaginalis ran, putative 0.0022 0.016 0.0924
Toxoplasma gondii preprocathepsin c precursor, putative 0.0034 0.0288 0.1661
Echinococcus multilocularis neural cadherin 0.0043 0.039 0.039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0288 0.1661
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1347 0.2712
Brugia malayi EGF-like domain containing protein 0.0043 0.039 0.0785
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0043 0.039 0.0785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0199 0.0423
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0186 0.0324
Echinococcus granulosus neurogenic locus notch protein 4 0.0043 0.039 0.0785
Schistosoma mansoni hypothetical protein 0.0044 0.0411 0.0827
Loa Loa (eye worm) animal heme peroxidase 0.0132 0.1409 0.2837
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0718 0.14
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0124 0.1731
Plasmodium vivax vivapain-1 0.0071 0.0718 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.1409 0.2837
Brugia malayi MH1 domain containing protein 0.0009 0.0002 0.0004
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0121 0.1283 0.2583
Loa Loa (eye worm) hypothetical protein 0.0132 0.1409 0.2837
Entamoeba histolytica cysteine protease, putative 0.0071 0.0718 0.6357
Giardia lamblia Cathepsin B precursor 0.016 0.1735 1
Brugia malayi MH2 domain containing protein 0.0009 0.0002 0.0004
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0026 0.0026
Entamoeba histolytica cysteine protease, putative 0.0071 0.0718 0.6357
Brugia malayi hypothetical protein 0.002 0.0134 0.027
Echinococcus granulosus nibrin 0.0011 0.0026 0.0053
Giardia lamblia Cysteine protease 0.0034 0.0288 0.1533
Onchocerca volvulus 0.0071 0.0718 0.5003
Schistosoma mansoni ap endonuclease 0.002 0.0131 0.0264
Brugia malayi MH1 domain containing protein 0.0009 0.0002 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0288 0.2552
Echinococcus granulosus notch 0.0043 0.039 0.0785
Loa Loa (eye worm) hypothetical protein 0.0132 0.1409 0.2837
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0071 0.0718 0.0718
Giardia lamblia Cathepsin B precursor 0.0034 0.0288 0.1533
Brugia malayi Calcium binding EGF domain containing protein 0.0043 0.039 0.0785
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0134 0.027
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0443 0.4966 1
Schistosoma mansoni cell polarity protein 0.0043 0.039 0.0785
Schistosoma mansoni rab6-interacting 0.002 0.0134 0.027
Leishmania major cathepsin L-like protease 0.0071 0.0718 0.3659
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0443 0.4966 1
Entamoeba histolytica hypothetical protein 0.0011 0.0026 0.0233
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0288 0.058
Leishmania major cathepsin L-like protease 0.0071 0.0718 0.3659
Loa Loa (eye worm) Smad1 0.0009 0.0002 0.0004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0186 0.1074
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0026 0.0151
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0592 0.0592
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0592 0.3413
Entamoeba histolytica cysteine proteinase, putative 0.0071 0.0718 0.6357
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0053
Entamoeba histolytica hypothetical protein 0.0034 0.0288 0.2552
Plasmodium falciparum serine repeat antigen 7 0.0034 0.0288 0.3787
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0071 0.0718 0.1446
Schistosoma mansoni hypothetical protein 0.0044 0.0411 0.0827
Schistosoma mansoni notch 0.0043 0.039 0.0785
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0034 0.0288 0.2552
Echinococcus granulosus cathepsin l cysteine peptidase 0.0071 0.0718 0.1446
Loa Loa (eye worm) hypothetical protein 0.0026 0.0199 0.04
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Echinococcus multilocularis protein patched 0.0046 0.043 0.043
Schistosoma mansoni smad1 5 8 and 0.0009 0.0002 0.0004
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0034 0.0288 0.2552
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0718 0.4138
Schistosoma mansoni cathepsin S (C01 family) 0.0034 0.0288 0.058
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.016 0.0323
Onchocerca volvulus 0.0043 0.039 0.2631
Brugia malayi RNA binding protein 0.0069 0.0692 0.1394
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0252 0.1454
Schistosoma mansoni notch 0.0043 0.039 0.0785
Loa Loa (eye worm) hypothetical protein 0.0132 0.1409 0.2837
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0199 0.04
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.016 0.1735 0.3459
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Giardia lamblia Cathepsin B precursor 0.0034 0.0288 0.1533
Trypanosoma cruzi cysteine proteinase, putative 0.0071 0.0718 0.14
Trypanosoma cruzi cysteine protease, putative 0.0071 0.0718 0.14
Brugia malayi CHE-14 protein 0.0046 0.043 0.0865
Trypanosoma cruzi cruzipain precursor, putative 0.0038 0.0333 0.0622
Brugia malayi EGF-like domain containing protein 0.0043 0.039 0.0785
Echinococcus multilocularis importin subunit beta 1 0.003 0.0252 0.0252
Plasmodium falciparum serine repeat antigen 1 0.0034 0.0288 0.3787
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Brugia malayi TAR-binding protein 0.0069 0.0692 0.1394
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0339 0.0339
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0718 0.4138
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0718 0.14
Echinococcus granulosus smad 0.0009 0.0002 0.0004
Schistosoma mansoni peroxidasin 0.0132 0.1409 0.2837
Brugia malayi hypothetical protein 0.0038 0.0339 0.0682
Giardia lamblia Cathepsin L precursor 0.0034 0.0288 0.1533
Echinococcus multilocularis cathepsin L 0.0034 0.0288 0.0288
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0592 0.1192
Schistosoma mansoni loxhd1 0.002 0.0134 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0288 0.1661
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.043 0.2477
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0692 0.1394
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.0333 0.0671
Loa Loa (eye worm) hypothetical protein 0.0132 0.1409 0.2837
Brugia malayi cathepsin B-like cysteine proteinase 0.0443 0.4966 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Onchocerca volvulus 0.0043 0.039 0.2631
Brugia malayi DKFZp564C0469 protein 0.0011 0.0026 0.0053
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0134 0.1561
Schistosoma mansoni hypothetical protein 0.0043 0.039 0.0785
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.113 0.2274
Brugia malayi Cathepsin L-like cysteine proteinase 0.0034 0.0288 0.058
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0134 0.1561
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0124 0.0251
Giardia lamblia Cathepsin L precursor 0.0034 0.0288 0.1533
Onchocerca volvulus Neurogenic locus notch homolog 0.0043 0.039 0.2631
Schistosoma mansoni ran 0.0022 0.016 0.0323
Brugia malayi Animal haem peroxidase family protein 0.0132 0.1409 0.2837
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0014 0.0068 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0718 0.4138
Giardia lamblia Cysteine protease 0.0034 0.0288 0.1533
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0186 0.1074
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0443 0.4966 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0692 0.1394
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0071 0.0718 1
Loa Loa (eye worm) animal heme peroxidase 0.0132 0.1409 0.2837
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0288 0.058
Onchocerca volvulus 0.0071 0.0718 0.5003
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0026 0.0151
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0134 0.027
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0026 0.0053
Onchocerca volvulus 0.0043 0.039 0.2631
Brugia malayi Cadherin domain containing protein 0.0043 0.039 0.0785
Toxoplasma gondii cathepsin CPL 0.0071 0.0718 0.4138
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0692 0.1394
Entamoeba histolytica cysteine protease, putative 0.0071 0.0718 0.6357
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0718 0.14
Schistosoma mansoni hypothetical protein 0.0043 0.039 0.0785
Brugia malayi Cathepsin L-like precursor 0.0071 0.0718 0.1446
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.025
Echinococcus multilocularis notch 0.0043 0.039 0.039
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0592 1
Entamoeba histolytica cysteine proteinase, putative 0.0071 0.0718 0.6357
Brugia malayi hypothetical protein 0.002 0.0134 0.027
Onchocerca volvulus 0.0043 0.039 0.2631
Loa Loa (eye worm) Notch2 0.0043 0.039 0.0785
Loa Loa (eye worm) doublecortin family protein 0.002 0.0134 0.027
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0026 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0034 0.0288 0.1661
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0199 0.1806
Echinococcus granulosus cathepsin b 0.0443 0.4966 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0131 0.0264
Schistosoma mansoni DNA ligase IV 0.0011 0.0026 0.0053
Brugia malayi Papain family cysteine protease containing protein 0.0071 0.0718 0.1446
Loa Loa (eye worm) cysteine protease 0.0071 0.0718 0.1446
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.016 0.016
Onchocerca volvulus 0.002 0.0134 0.0781
Brugia malayi Cathepsin L-like precursor 0.0071 0.0718 0.1446
Brugia malayi Delta serrate ligand family protein 0.0043 0.039 0.0785
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0199 0.1761
Giardia lamblia Cathepsin B precursor 0.016 0.1735 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0131 0.1515
Brugia malayi hypothetical protein 0.0011 0.0026 0.0053
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0186 0.1074
Echinococcus granulosus Smad4 0.0009 0.0002 0.0004
Schistosoma mansoni septate junction protein 0.0043 0.039 0.0785
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0692 0.1394
Leishmania major cathepsin L-like protease 0.0071 0.0718 0.3659
Echinococcus multilocularis smad 0.0009 0.0002 0.0002
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0034 0.0288 0.058
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0199 0.305
Echinococcus multilocularis neurogenic locus notch protein 4 0.0043 0.039 0.039
Schistosoma mansoni hypothetical protein 0.0043 0.039 0.0785
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0131 0.1515
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Echinococcus multilocularis protein jagged 1 0.0043 0.039 0.039
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0131 0.0755
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0034 0.0288 0.1661
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0131 0.0212
Schistosoma mansoni ap endonuclease 0.002 0.0131 0.0264
Schistosoma mansoni notch 0.0043 0.039 0.0785
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0592 0.1192
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0288 0.058
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0034 0.0288 0.058
Brugia malayi MH2 domain containing protein 0.0009 0.0002 0.0004
Schistosoma mansoni rab6-interacting 0.002 0.0134 0.027
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Echinococcus multilocularis RUN 0.002 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0038 0.0333 0.0671
Schistosoma mansoni notch 0.0043 0.039 0.0785
Schistosoma mansoni cathepsin B (C01 family) 0.0034 0.0288 0.058
Loa Loa (eye worm) hypothetical protein 0.0034 0.0288 0.058
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0288 0.058
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0034 0.0288 0.3787
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.016 0.0271
Loa Loa (eye worm) hypothetical protein 0.0038 0.0333 0.0671
Entamoeba histolytica cysteine protease, putative 0.0071 0.0718 0.6357
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0053
Giardia lamblia Cathepsin L precursor 0.0034 0.0288 0.1533
Entamoeba histolytica cysteine protease, putative 0.0071 0.0718 0.6357
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0026 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0718 0.4138
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0071 0.0718 0.1446
Echinococcus granulosus cathepsin L 0.0034 0.0288 0.058
Echinococcus multilocularis neurogenic locus notch protein 0.0043 0.039 0.039
Echinococcus granulosus fibropellin Ia 0.0043 0.039 0.0785
Entamoeba histolytica cysteine protease, putative 0.0071 0.0718 0.6357
Loa Loa (eye worm) hypothetical protein 0.0132 0.1409 0.2837
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0288 0.1661
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0288 0.058
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0199 0.305
Schistosoma mansoni hypothetical protein 0.0043 0.039 0.0785
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0071 0.0718 0.1446
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0131 0.0755
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0134 0.0134
Brugia malayi EGF-like domain containing protein 0.0043 0.039 0.0785
Entamoeba histolytica cysteine protease, putative 0.0034 0.0288 0.2552
Giardia lamblia Encystation-specific protease 0.0034 0.0288 0.1533
Plasmodium vivax serine-repeat antigen (SERA) 0.0034 0.0288 0.3787
Schistosoma mansoni smad 0.0009 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0718 0.4138
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.025
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0199 0.0423
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0124 1
Loa Loa (eye worm) RNA binding protein 0.0069 0.0692 0.1394
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0071 0.0718 0.1446
Echinococcus multilocularis protein jagged 1 0.0043 0.039 0.039
Leishmania major cathepsin L-like protease 0.0071 0.0718 0.3659
Echinococcus granulosus protein jagged 1 0.0043 0.039 0.0785
Brugia malayi protein kinase C II. 0.0014 0.0068 0.0137
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0034 0.0288 0.3787
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0053
Brugia malayi Cathepsin L-like precursor 0.0034 0.0288 0.058
Plasmodium vivax vivapain-2 0.0071 0.0718 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Loa Loa (eye worm) animal heme peroxidase 0.0132 0.1409 0.2837
Echinococcus multilocularis Niemann Pick C1 protein 0.0153 0.1656 0.1656
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0131 0.0393
Brugia malayi notch-like transmembrane receptor 0.0043 0.039 0.0785
Plasmodium falciparum serine repeat antigen 2 0.0034 0.0288 0.3787
Loa Loa (eye worm) hypothetical protein 0.0034 0.0288 0.058
Loa Loa (eye worm) hypothetical protein 0.0443 0.4966 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0718 0.4138
Loa Loa (eye worm) cathepsin B 0.016 0.1735 0.3494
Echinococcus multilocularis fat cadherin tumor suppressor 0.0043 0.039 0.039
Onchocerca volvulus Putative cubilin 0.0043 0.039 0.2631
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0124 0.1417
Brugia malayi Blistered cuticle protein 3 0.0132 0.1409 0.2837
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0131 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0443 0.4966 1
Schistosoma mansoni lipoxygenase 0.0084 0.0868 0.1747
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0034 0.0288 0.3787
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Onchocerca volvulus Cathepsin L homolog 0.0071 0.0718 0.5003
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0592 1
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0134 0.027
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0132 0.1409 0.2837
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0131 0.0755
Brugia malayi cathepsin F-like cysteine proteinase 0.0038 0.0333 0.0671
Leishmania major importin beta-1 subunit, putative 0.0025 0.0186 0.0345
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0034 0.0288 0.058
Schistosoma mansoni cathepsin s 0.0038 0.0333 0.0671
Onchocerca volvulus Slit protein homolog 0.0043 0.039 0.2631
Onchocerca volvulus Cathepsin L homolog 0.0071 0.0718 0.5003
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0199 0.04
Loa Loa (eye worm) hypothetical protein 0.0038 0.0333 0.0671
Trypanosoma cruzi major cysteine proteinase, putative 0.0034 0.0288 0.053
Plasmodium falciparum serine repeat antigen 4 0.0034 0.0288 0.3787
Echinococcus granulosus neural cadherin 0.0043 0.039 0.0785
Leishmania major cathepsin L-like protease 0.0071 0.0718 0.3659
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0038 0.0333 0.0671
Plasmodium falciparum serine repeat antigen 5 0.0034 0.0288 0.3787
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0034 0.0288 0.3787
Loa Loa (eye worm) ctsf protein 0.0071 0.0718 0.1446
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0199 0.1761
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0071 0.0718 0.0718
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0199 0.1806
Echinococcus granulosus cathepsin L cysteine protease 0.0071 0.0718 0.1446
Trypanosoma cruzi cysteine proteinase, putative 0.0071 0.0718 0.14
Echinococcus multilocularis neurogenic locus notch protein 0.0043 0.039 0.039
Giardia lamblia Cathepsin B precursor 0.0034 0.0288 0.1533
Plasmodium vivax unspecified product 0.0071 0.0718 1
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0692 0.1394
Schistosoma mansoni cathepsin F (C01 family) 0.0071 0.0718 0.1446
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0043 0.039 0.0785
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0034 0.0288 0.3787
Giardia lamblia Cathepsin B precursor 0.0034 0.0288 0.1533
Plasmodium vivax unspecified product 0.0034 0.0288 0.3787
Loa Loa (eye worm) hypothetical protein 0.0046 0.043 0.0865
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0288 0.1661
Loa Loa (eye worm) hypothetical protein 0.0132 0.1409 0.2837
Brugia malayi topoisomerase 0.0011 0.0026 0.0053
Echinococcus granulosus protein jagged 2 0.0043 0.039 0.0785
Leishmania major GTP-binding protein, putative 0.0022 0.016 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0718 0.4138
Schistosoma mansoni topbp1 0.0011 0.0026 0.0053
Entamoeba histolytica hypothetical protein 0.0038 0.0339 0.2998
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.043 0.0865
Giardia lamblia Cysteine protease 0.0034 0.0288 0.1533
Onchocerca volvulus 0.0034 0.0288 0.1895
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0026 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0071 0.0718 0.4138
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0785
Brugia malayi GCC2 and GCC3 family protein 0.0043 0.039 0.0785
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0044 0.0411 0.0827
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.025
Entamoeba histolytica cysteine protease, putative 0.0034 0.0288 0.2552
Loa Loa (eye worm) hypothetical protein 0.0132 0.1409 0.2837
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0134 0.0134
Giardia lamblia Cathepsin L precursor 0.0034 0.0288 0.1533
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0288 0.1661
Schistosoma mansoni notch 0.0043 0.039 0.0785
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.016 0.0924
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0068 0.0137
Echinococcus granulosus cathepsin L 0.0071 0.0718 0.1446
Brugia malayi cathepsin Z-like cysteine proteinase 0.0034 0.0288 0.058
Schistosoma mansoni hypothetical protein 0.0043 0.039 0.0785
Echinococcus granulosus neurogenic locus protein delta 0.0043 0.039 0.0785
Plasmodium falciparum serine repeat antigen 9 0.0034 0.0288 0.3787
Schistosoma mansoni polycystin 1-related 0.002 0.0134 0.027
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0199 0.305

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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