Detailed information for compound 799187

Basic information

Technical information
  • TDR Targets ID: 799187
  • Name: 4-methoxy-6-pyrrolidin-1-yl-1H-1,3,5-triazin- 2-one
  • MW: 196.206 | Formula: C8H12N4O2
  • H donors: 1 H acceptors: 4 LogP: 1.2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1nc(nc(n1)O)N1CCCC1
  • InChi: 1S/C8H12N4O2/c1-14-8-10-6(9-7(13)11-8)12-4-2-3-5-12/h2-5H2,1H3,(H,9,10,11,13)
  • InChiKey: PXZBFFZGYMGEHY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methoxy-6-1-pyrrolidinyl-1H-1,3,5-triazin-2-one
  • 4-methoxy-6-pyrrolidin-1-yl-1H-s-triazin-2-one
  • A3274/0139258
  • ChemDiv2_002606
  • ZINC00109010

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.002 0.0057 0.0062
Schistosoma mansoni hypothetical protein 0.0047 0.037 0.0385
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.024 0.2722
Brugia malayi Bromodomain containing protein 0.0073 0.0672 0.0626
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0076 0.0705 0.0774
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0076 0.0705 0.0705
Echinococcus multilocularis geminin 0.0334 0.3709 0.4014
Echinococcus multilocularis zinc finger protein 0.0019 0.0043 0.0044
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0053 0.0441 0.0441
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.005 0.0405 0.0441
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0705 0.0705
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0049 0.0051
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0067 0.0069
Loa Loa (eye worm) fatty acid synthase 0.005 0.0397 0.0383
Schistosoma mansoni hypothetical protein 0.0047 0.037 0.0385
Mycobacterium ulcerans thioesterase 0.0042 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0037 0.0256 0.0242
Brugia malayi Flap endonuclease-1 0.0025 0.0115 0.0066
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.037 0.0398
Mycobacterium ulcerans Type I modular polyketide synthase 0.005 0.0405 0.0405
Mycobacterium leprae Probable polyketide synthase Pks1 0.0053 0.0441 0.0481
Brugia malayi beta-lactamase 0.0036 0.024 0.0192
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0076 0.0705 0.0705
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0049 0.0051
Trichomonas vaginalis antibiotic synthetase, putative 0.0076 0.0705 1
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0016 0.0002 0.0002
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0081 0.0764 0.0764
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0705 0.0659
Loa Loa (eye worm) hypothetical protein 0.0095 0.0925 0.0912
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.144 0.1398
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.024 0.0264
Loa Loa (eye worm) acyl carrier protein 0.0023 0.0089 0.0075
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0705 0.0705
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0792 0.903 0.9775
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0705 0.0774
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.024 0.024
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0403 0.4873
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0014 0.0013
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0115 0.0052
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0049 0.0038
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0049 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.144 0.1557
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0049 0.0051
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0035
Echinococcus granulosus zinc finger protein 0.0019 0.0043 0.0044
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0016 0.0002 0.0002
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.081 0.9238 1
Leishmania major acetyl-CoA synthetase, putative 0.0076 0.0705 0.0706
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0049 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0049 0.0035
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0403 0.4873
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0123 0.1251 0.1373
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0033 0.0207 0.0224
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0049 0.0051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0049 0.0051
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0115 1
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0115 0.0121
Brugia malayi Bromodomain containing protein 0.0037 0.0255 0.0207
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0228 0.0245
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.024 0.0192
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0498 0.0537
Onchocerca volvulus Fatty acid synthase homolog 0.0091 0.0873 0.4926
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0049 0.0035
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0049 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0705 0.0705
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0076 0.0705 0.0697
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0705 0.0771
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.024 0.024
Mycobacterium leprae conserved hypothetical protein 0.0036 0.024 0.0261
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0076 0.008
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0081 0.0764 0.0719
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0049 0.0038
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0076 0.0068
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0067 0.0017
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0033 0.0199 0.1434
Mycobacterium ulcerans hypothetical protein 0.0076 0.0705 0.0705
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.005 0.0405 0.0444
Mycobacterium ulcerans polyketide synthase Pks13 0.0075 0.0693 0.0693
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.024 0.019
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0035
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0049 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.144 0.1546
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0076 0.0705 1
Mycobacterium ulcerans lipase LipD 0.0036 0.024 0.024
Echinococcus granulosus FTZ F1 alpha 0.002 0.0049 0.0051
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.024 0.0264
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0014 0.0013
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0067 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.024 0.0227
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0035
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0123 0.1251 0.1239
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0076 0.0705 0.0771
Onchocerca volvulus 0.0123 0.1251 0.7185
Echinococcus granulosus flap endonuclease 1 0.0025 0.0115 0.0121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0705 0.0774
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0035
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0017 0.0021 0.0023
Plasmodium vivax acetyl-CoA synthetase, putative 0.0076 0.0705 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0049 0.0051
Loa Loa (eye worm) hypothetical protein 0.0047 0.037 0.0356
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0036 0.024 0.0263
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.004 0.029 0.029
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.1556 0.1514
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0081 0.0764 0.0839
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0076 0.0705 0.0705
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0049 0.0051
Mycobacterium tuberculosis Conserved protein 0.0036 0.024 0.0264
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0041 0.0298 0.0327
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.004 0.029 0.0316
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.005 0.0405 0.0444
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0228 0.0245
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0049 0.0035
Echinococcus multilocularis long chain fatty acid transport protein 4 0.081 0.9238 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0049 0.0051
Schistosoma mansoni FFA transport protein 0.081 0.9238 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0498 0.0537
Brugia malayi hypothetical protein 0.0032 0.0196 0.0148
Schistosoma mansoni coup transcription factor 0.002 0.0049 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0705 0.0705
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.1556 0.1514
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0049 0.0035
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.037 0.0356
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0076 0.0705 0.0705
Schistosoma mansoni hypothetical protein 0.0102 0.1007 0.1076
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0081 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.144 0.1557
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0705 0.0659
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0081 0.0764 0.0839
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0014 0.0013
Toxoplasma gondii type I fatty acid synthase, putative 0.0036 0.0236 0.2058
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0705 0.0659
Echinococcus granulosus geminin 0.0334 0.3709 0.4014
Brugia malayi beta-lactamase family protein 0.0036 0.024 0.0192
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.144 0.1557
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.004 0.0283 0.0269
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0053 0.0441 0.0484
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.024 0.2722
Trichomonas vaginalis antibiotic synthetase, putative 0.0076 0.0705 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0033 0.0207 0.0207
Echinococcus granulosus dna polymerase kappa 0.0021 0.0067 0.0069
Mycobacterium ulcerans acetyl-CoA synthetase 0.0076 0.0705 0.0705
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0049 0.0051
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0403 0.4873
Brugia malayi PHD-finger family protein 0.0024 0.0103 0.0054
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1169 0.1157
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0021 0.0007
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0403 0.5258
Leishmania major hypothetical protein, conserved 0.005 0.0403 0.0371
Echinococcus multilocularis GPCR, family 2 0.0047 0.037 0.0398
Loa Loa (eye worm) hypothetical protein 0.0076 0.0705 0.0692
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0042 0.0307 0.0334
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0081 0.0764 0.0764
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0081 0.0086
Loa Loa (eye worm) hypothetical protein 0.0076 0.0705 0.0692
Schistosoma mansoni hypothetical protein 0.002 0.0055 0.0044
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0049 0.0051
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0076 0.0705 0.0705
Schistosoma mansoni thyroid hormone receptor 0.002 0.0049 0.0038
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.005 0.0405 0.0405
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0076 0.0705 0.0697
Trichomonas vaginalis esterase, putative 0.0036 0.024 0.2722
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0049 0.0051
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.037 0.0398
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0049 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0705 0.0705
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.024 0.0264
Toxoplasma gondii propionate-CoA ligase 0.0076 0.0705 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.024 0.0245
Onchocerca volvulus 0.0076 0.0705 0.3922
Mycobacterium ulcerans hypothetical protein 0.0036 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0053
Toxoplasma gondii type I fatty acid synthase, putative 0.0064 0.0564 0.7603
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0067 0.0069
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0705 0.0659
Loa Loa (eye worm) hypothetical protein 0.0028 0.0148 0.0134
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0081 0.0764 0.0764
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.037 0.0398
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0067 0.0842
Loa Loa (eye worm) hypothetical protein 0.0149 0.1556 0.1544
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0705 0.9226
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.024 0.019
Schistosoma mansoni hypothetical protein 0.0334 0.3709 0.4006
Onchocerca volvulus 0.0076 0.0705 0.3922
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0403 0.0366
Schistosoma mansoni flap endonuclease-1 0.0023 0.0086 0.0078
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0799 0.9115 1
Echinococcus granulosus dna polymerase eta 0.0021 0.0067 0.0069
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1169 0.1157
Brugia malayi MH2 domain containing protein 0.0116 0.1169 0.1125
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0705 0.0706
Loa Loa (eye worm) hypothetical protein 0.0036 0.024 0.0227
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0115 0.0752
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.024 0.0264
Loa Loa (eye worm) oxidoreductase 0.0076 0.0705 0.0692
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0705 0.0771
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0049 0.0387 0.0424
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0035
Entamoeba histolytica acyl-CoA synthetase, putative 0.0081 0.0764 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0076 0.0705 0.0774
Mycobacterium ulcerans polyketide synthase Pks9 0.0033 0.0207 0.0207
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.005 0.0405 0.0357
Schistosoma mansoni DNA polymerase eta 0.0021 0.0067 0.0057
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0076 0.0705 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.024 0.0227
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0705 0.0705
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0075 0.0693 0.0761
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.2504 0.2747
Loa Loa (eye worm) hypothetical protein 0.005 0.0403 0.0389
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0049 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0035
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0067 0.0067
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0403 0.4873
Schistosoma mansoni bromodomain containing protein 0.0062 0.0539 0.0569
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0799 0.9115 1
Leishmania major acetyl-CoA synthetase, putative 0.0076 0.0705 0.0706
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0049 0.0038
Onchocerca volvulus 0.0036 0.024 0.1143
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0049 0.0387 0.0424
Schistosoma mansoni nuclear hormone receptor 0.002 0.0049 0.0038
Loa Loa (eye worm) hypothetical protein 0.0042 0.0305 0.0291
Leishmania major fatty acid transporter protein-like protein 0.0799 0.9115 1
Schistosoma mansoni hypothetical protein 0.0047 0.037 0.0385
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.024 0.2722
Loa Loa (eye worm) hypothetical protein 0.0076 0.0705 0.0692
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.024 0.2722
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.144 0.1557
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0053 0.0441 0.0484
Mycobacterium tuberculosis Conserved protein 0.0036 0.024 0.0264
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0705 0.0771
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0705 0.0659
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0067 0.0073
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0055 0.0041
Mycobacterium tuberculosis Conserved protein 0.0036 0.024 0.0264
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.024 0.0258
Brugia malayi Latrophilin receptor protein 2 0.0047 0.037 0.0322
Echinococcus granulosus long chain fatty acid transport protein 4 0.081 0.9238 1
Mycobacterium ulcerans polyketide synthase 0.005 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0076 0.0705 0.0692
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0066 0.0582 0.0639
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0049 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0705 0.0705
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0035
Toxoplasma gondii ABC1 family protein 0.0036 0.024 0.2131
Mycobacterium ulcerans Type I modular polyketide synthase 0.005 0.0405 0.0405
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.144 0.1546
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0076 0.0705 0.0659
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0705 0.0774
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0049 0.0051
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.081 0.9238 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0067 0.0057
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0016 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0049 0.0035
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0081 0.0764 0.0839
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0036 0.0239 0.2099
Mycobacterium tuberculosis Probable thioesterase TesA 0.0042 0.0307 0.0337
Onchocerca volvulus 0.0163 0.1722 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.024 0.0245
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0705 0.0705
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0049 0.0051
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0029 0.0152 0.0167
Mycobacterium ulcerans polyketide synthase 0.0053 0.0441 0.0441
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.024 0.0264
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0403 0.0366
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0081 0.0764 0.0836
Loa Loa (eye worm) beta-lactamase 0.0036 0.024 0.0227
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0076 0.0705 0.0774
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0705 0.0774
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0076 0.0705 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0076 0.0705 0.0706
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0081 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0076 0.0705 0.0692
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0705 0.0706
Plasmodium vivax hypothetical protein, conserved 0.0036 0.024 0.2131
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0076 0.0705 1
Schistosoma mansoni hypothetical protein 0.0022 0.0081 0.0073
Brugia malayi beta-lactamase family protein 0.0036 0.024 0.0192
Schistosoma mansoni acetyl-CoA synthetase 0.0076 0.0705 0.075
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0115 0.0752
Mycobacterium ulcerans thioesterase TesA 0.0042 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0102 0.1007 0.0994
Mycobacterium ulcerans acyl-CoA synthetase 0.0081 0.0764 0.0764
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.1007 0.0962
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0049 0.0038
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0076 0.0705 0.0761
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.024 0.2722
Schistosoma mansoni zinc finger protein 0.0019 0.0043 0.0031
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.144 0.1428
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.037 0.0322
Schistosoma mansoni thyroid hormone receptor 0.002 0.0049 0.0038
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0076 0.008
Mycobacterium ulcerans beta-lactamase 0.0036 0.024 0.024
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0115 0.0053
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0036 0.024 0.0227
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0016 0.0004 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0705 0.0706
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0067 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0705 0.0705
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0705 0.0774
Loa Loa (eye worm) hypothetical protein 0.0036 0.024 0.0227
Onchocerca volvulus 0.0036 0.024 0.1143
Mycobacterium ulcerans fatty acid synthase Fas 0.0016 0.0004 0.0004
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0076 0.0705 0.0705
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0705 0.0705
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0076 0.0705 0.0705
Schistosoma mansoni hypothetical protein 0.0334 0.3709 0.4006
Brugia malayi AMP-binding enzyme family protein 0.0123 0.1251 0.1208
Onchocerca volvulus 0.0081 0.0764 0.4275
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0076 0.0705 0.0697
Loa Loa (eye worm) hypothetical protein 0.0069 0.0624 0.061
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0067 0.0069
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.037 0.0398
Mycobacterium leprae Probable lipase LipE 0.0036 0.024 0.0261
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0095 0.0928 0.0883
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0076 0.0705 0.0697
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0115 0.0101
Loa Loa (eye worm) hypothetical protein 0.0036 0.024 0.0227
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0115 0.1472
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.024 0.2722
Onchocerca volvulus 0.0036 0.024 0.1143
Brugia malayi hypothetical protein 0.005 0.0403 0.0355
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.005 0.0405 0.0441
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0049 0.0051
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0076 0.0705 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0002 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0123 0.0074
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0053 0.0441 0.0441
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0049 0.0038
Mycobacterium ulcerans Type I modular polyketide synthase 0.005 0.0405 0.0405
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.005 0.0405 0.0444
Echinococcus multilocularis dna polymerase eta 0.0021 0.0067 0.0069
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.024 0.0258
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0067 0.0073
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0075 0.0693 0.0761
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0053 0.0441 0.0481
Echinococcus granulosus GPCR family 2 0.0047 0.037 0.0398
Schistosoma mansoni hypothetical protein 0.0047 0.037 0.0385
Loa Loa (eye worm) hypothetical protein 0.0036 0.024 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0049 0.0035
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0875 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0067 0.0057
Entamoeba histolytica acyl-coA synthetase, putative 0.0076 0.0705 0.9226
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0875 1 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0076 0.0705 0.0761
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.024 0.0264
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.024 0.0264
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0081 0.0764 0.0839
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0076 0.0705 0.9226
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0049 0.0038
Leishmania major hypothetical protein, conserved 0.0036 0.024 0.0192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.144 0.1546
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0049 0.0038
Mycobacterium leprae Polyketide synthase Pks13 0.0075 0.0693 0.0758
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.1556 0.1544
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.004 0.029 0.029
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0053 0.0441 0.0484
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0053 0.0441 0.0481

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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