Detailed information for compound 801392

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 379.366 | Formula: C20H17N3O5
  • H donors: 0 H acceptors: 5 LogP: 3.29 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CC(=Cc2ccc(cc2)[N+](=O)[O-])C(=O)C(=Cc2ccc(cc2)[N+](=O)[O-])C1
  • InChi: 1S/C20H17N3O5/c1-21-12-16(10-14-2-6-18(7-3-14)22(25)26)20(24)17(13-21)11-15-4-8-19(9-5-15)23(27)28/h2-11H,12-13H2,1H3/b16-10-,17-11+
  • InChiKey: RZSZIUWKHOTPLG-VRNBXGKJSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0138 0.308
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0137 0.046
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0138 0.0412
Loa Loa (eye worm) hypothetical protein 0.011 0.0624 0.1988
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0138 0.0464
Plasmodium vivax unspecified product 0.0018 0.0032 0.0073
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0138 0.0464
Brugia malayi beta-lactamase family protein 0.011 0.0624 0.1965
Schistosoma mansoni microtubule-associated protein tau 0.1392 0.8832 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.0581 0.3201
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0067 0.0894
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0115 0.0115
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0122 0.0404
Brugia malayi MH1 domain containing protein 0.0017 0.0025 0.0051
Schistosoma mansoni hypothetical protein 0.0031 0.0115 0.0117
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0032 0.0074
Echinococcus multilocularis cysteine protease 0.0034 0.0138 0.0138
Brugia malayi Cathepsin L-like precursor 0.0034 0.0138 0.0412
Echinococcus multilocularis musashi 0.0026 0.0087 0.0087
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0538 0.1692
Loa Loa (eye worm) cysteine protease 0.0034 0.0138 0.044
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0122 0.0122
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0025 0.0079
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0067 0.0204
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0033 0.0132 0.0132
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0067 0.0062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0138 0.0138
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0025 0.0025
Leishmania major cathepsin L-like protease 0.0034 0.0138 0.0471
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0122 0.0404
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.1398 0.1398
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0032 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus granulosus solute carrier family 22 0.0015 0.0012 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0137 0.2045
Entamoeba histolytica hypothetical protein 0.0034 0.0137 0.3052
Schistosoma mansoni lamin 0.0026 0.0087 0.0085
Onchocerca volvulus 0.0026 0.0087 0.0241
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0117 0.1725
Onchocerca volvulus 0.0034 0.0138 0.0403
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0138 0.0138
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0122 0.0404
Leishmania major cathepsin L-like protease 0.0034 0.0138 0.0471
Echinococcus granulosus transcription factor btf3 0.0034 0.0137 0.0155
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0624 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0624 0.1965
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0581 0.0658
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0115 0.013
Trypanosoma cruzi hexose transporter 0.0032 0.0124 0.042
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0294 0.4616
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0377 0.0414
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Loa Loa (eye worm) ctsf protein 0.0034 0.0138 0.044
Echinococcus multilocularis neuropeptide receptor A26 0.046 0.2868 0.2868
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0032 0.0324
Schistosoma mansoni intermediate filament proteins 0.0026 0.0087 0.0085
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0015 0.0015
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0432 0.2688 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0167 0.0989 0.5495
Echinococcus multilocularis lamin dm0 0.0026 0.0087 0.0087
Brugia malayi Cathepsin L-like precursor 0.0034 0.0138 0.0412
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0624 0.0624
Brugia malayi major facilitator superfamily protein 0.0015 0.0012 0.0009
Echinococcus granulosus metabotropic glutamate receptor 2 0.0033 0.0132 0.0149
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0048 0.0596
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0025 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0124 0.1835
Schistosoma mansoni hypothetical protein 0.0031 0.0115 0.0117
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.0754 0.2774
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0015 0.0048
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0124 0.042
Echinococcus multilocularis geminin 0.0669 0.4206 0.4206
Brugia malayi Sugar transporter family protein 0.0015 0.0012 0.0009
Mycobacterium ulcerans hypothetical protein 0.011 0.0624 1
Brugia malayi MH1 domain containing protein 0.0017 0.0025 0.0051
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0122 0.0138
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0624 0.2287
Brugia malayi beta-lactamase family protein 0.011 0.0624 0.1965
Plasmodium falciparum protein kinase 7 0.0292 0.179 0.6542
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0294 0.4616
Leishmania major glucose transporter, lmgt3 0.0032 0.0124 0.042
Schistosoma mansoni protein kinase 0.0032 0.0122 0.0124
Trypanosoma brucei C-8 sterol isomerase, putative 0.0432 0.2688 1
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0137 0.0468
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0117 0.012
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0124 0.042
Leishmania major cathepsin L-like protease 0.0034 0.0138 0.0471
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0138 0.0471
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0374
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.1476 0.47
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Echinococcus granulosus cathepsin l1 0.0023 0.0066 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Schistosoma mansoni vesicular acetylcholine transporter 0.0503 0.314 0.3546
Schistosoma mansoni hypothetical protein 0.0669 0.4206 0.4755
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0117 0.0347
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0138 0.0156
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0138 0.308
Echinococcus multilocularis solute carrier family 22 0.0015 0.0012 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0122 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0167 0.0989 0.3595
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0122 0.0122
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0117 0.0347
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0137 0.046
Brugia malayi hypothetical protein 0.0015 0.0012 0.0009
Echinococcus multilocularis vesicular acetylcholine transporter 0.0503 0.314 0.314
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0115 0.0338
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0119 0.0682 0.2503
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0124 0.1835
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0122 0.0617
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0045 0.0208 0.0222
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0122 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0124 0.1835
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0067 0.0201
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0067 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.022 0.0676
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0624 0.0706
Plasmodium falciparum protein kinase 6 0.0439 0.273 1
Leishmania major hypothetical protein, conserved 0.011 0.0624 0.2287
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0012 0.0038
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0012 0.5
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0012 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0032 0.0074
Echinococcus granulosus intermediate filament protein 0.0026 0.0087 0.0099
Echinococcus granulosus lamin dm0 0.0026 0.0087 0.0099
Plasmodium vivax vivapain-2 0.0034 0.0138 0.0464
Toxoplasma gondii cathepsin CPL 0.0034 0.0138 0.0709
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0581 0.0658
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0122 0.041
Brugia malayi hypothetical protein 0.0231 0.1398 0.4437
Mycobacterium tuberculosis Conserved protein 0.011 0.0624 0.1387
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0294 0.4616
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0138 0.2061
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0503 0.314 1
Schistosoma mansoni hypothetical protein 0.0669 0.4206 0.4755
Schistosoma mansoni hypothetical protein 0.0066 0.0342 0.0375
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0294 0.064
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0137 0.2045
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0294 0.032
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0624 0.1988
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0124 0.1835
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0138 0.0403
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0624 1
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0624 0.1387
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0124 0.1835
Schistosoma mansoni glucose transport protein 0.0103 0.0581 0.0645
Leishmania major cathepsin L-like protease 0.013 0.0754 0.2774
Brugia malayi Sugar transporter family protein 0.0103 0.0581 0.1828
Brugia malayi major facilitator superfamily protein 0.0015 0.0012 0.0009
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0122 0.0122
Brugia malayi Smad1 0.0017 0.0025 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0138 0.2061
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0503 0.314 1
Echinococcus granulosus cysteine protease 0.0018 0.0032 0.0036
Echinococcus multilocularis microtubule associated protein 2 0.1392 0.8832 0.8832
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0624 1
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0032 0.0036
Loa Loa (eye worm) hypothetical protein 0.0034 0.0138 0.044
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0015 0.0017
Plasmodium falciparum proline--tRNA ligase 0.0036 0.015 0.051
Plasmodium vivax vivapain-3 0.0018 0.0032 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0212
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0624 0.1387
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.1398 0.1583
Brugia malayi Cathepsin L-like precursor 0.0023 0.0066 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Brugia malayi Cam kinase protein 1 0.0032 0.0122 0.036
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.015 0.0518
Brugia malayi hypothetical protein 0.0072 0.0377 0.1175
Schistosoma mansoni smad1 5 8 and 0.0017 0.0025 0.0015
Leishmania major cathepsin L-like protease 0.013 0.0754 0.2774
Brugia malayi Cathepsin L-like precursor 0.0034 0.0138 0.0412
Plasmodium vivax hexose transporter 0.0103 0.0581 0.2094
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0122 0.0404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0877
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0067 0.5182
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0032 0.0074
Brugia malayi hypothetical protein 0.0015 0.0012 0.0009
Brugia malayi Sugar transporter family protein 0.0015 0.0012 0.0009
Toxoplasma gondii ABC1 family protein 0.011 0.0624 0.3442
Loa Loa (eye worm) hypothetical protein 0.0097 0.0538 0.1715
Echinococcus granulosus cathepsin L 0.0018 0.0032 0.0036
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0124 0.042
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Brugia malayi Metabotropic glutamate receptor precursor. 0.004 0.0173 0.0524
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.0581 0.0581
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0124 0.1835
Entamoeba histolytica hypothetical protein 0.0072 0.0377 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0138 0.0471
Loa Loa (eye worm) glutamate receptor 0.0016 0.0019 0.006
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0137 0.0468
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0044 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0581 0.93
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0209
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0025 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0624 0.2287
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0122 0.0122
Onchocerca volvulus 0.0023 0.0066 0.0172
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0342 0.1065
Entamoeba histolytica cysteine protease, putative 0.0034 0.0138 0.308
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Loa Loa (eye worm) fibroinase 0.0034 0.0138 0.044
Schistosoma mansoni glucose transport protein 0.0103 0.0581 0.0645
Brugia malayi vesicular acetylcholine transporter unc-17 0.0503 0.314 1
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0122 0.1792
Schistosoma mansoni lamin 0.0026 0.0087 0.0085
Echinococcus multilocularis lamin 0.0026 0.0087 0.0087
Schistosoma mansoni survival motor neuron protein 0.0047 0.022 0.0236
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0115 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0137 0.2045
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0581 0.0658
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Brugia malayi MH2 domain containing protein 0.0243 0.1476 0.4685
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0137 0.3052
Leishmania major glucose transporter, lmgt2 0.0032 0.0124 0.042
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0087 0.0278
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0115 0.0115
Brugia malayi Cathepsin L-like precursor 0.0034 0.0138 0.0412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0294 0.0294
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0032 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0137 0.0704
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0025 0.0079
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0032 0.0022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0624 0.0694
Leishmania major cathepsin L-like protease 0.0034 0.0138 0.0471
Loa Loa (eye worm) hypothetical protein 0.011 0.0624 0.1988
Entamoeba histolytica hypothetical protein 0.0023 0.0067 0.1011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0294 0.0333
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0115 0.0366
Loa Loa (eye worm) hypothetical protein 0.0221 0.1334 0.4249
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0067 0.0384
Loa Loa (eye worm) sugar transporter 0.0015 0.0012 0.0038
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0122 0.0138
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0025 0.0025
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0044 0.0073
Echinococcus multilocularis cathepsin L 0.0018 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0087 0.0278
Toxoplasma gondii protein kinase, putative 0.0292 0.179 1
Echinococcus granulosus geminin 0.0669 0.4206 0.4762
Brugia malayi beta-NAC-like protein 0.0034 0.0137 0.0409
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.015 0.0518
Echinococcus granulosus GPCR family 2 0.0031 0.0115 0.013
Onchocerca volvulus 0.0034 0.0138 0.0403
Echinococcus granulosus solute carrier family 22 0.0015 0.0012 0.0013
Schistosoma mansoni smad1 5 8 and 0.0017 0.0025 0.0015
Echinococcus multilocularis solute carrier family 22 0.0015 0.0012 0.0012
Echinococcus granulosus General substrate transporter 0.0089 0.0488 0.0553
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0009 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0117 0.2484
Brugia malayi metabotropic glutamate receptor type 2 0.0019 0.0043 0.0108
Mycobacterium leprae Probable lipase LipE 0.011 0.0624 1
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0066 0.0061
Loa Loa (eye worm) hypothetical protein 0.0231 0.1398 0.4453
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0624 0.1387
Plasmodium falciparum mitogen-activated protein kinase 2 0.0167 0.0989 0.3595
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0067 0.0075
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0581 0.0581
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0066 0.0181
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0117 0.0133
Leishmania major protein kinase, putative 0.0032 0.0122 0.041
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0087 0.025
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0049 0.0232 0.0232
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0122 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0124 0.1835
Echinococcus granulosus cathepsin l1 0.0034 0.0138 0.0156
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0624 1
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0 0.0001
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0012 0.0038
Echinococcus granulosus neuropeptide receptor A26 0.046 0.2868 0.3247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0377 0.0427
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus multilocularis Smad4 0.0017 0.0025 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0138 0.0156
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0067 0.0062
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0137 0.0437
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.011 0.0624 0.1988
Echinococcus multilocularis solute carrier family 22 0.0015 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0374
Loa Loa (eye worm) hypothetical protein 0.011 0.0624 0.1988
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0209
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0138 0.044
Loa Loa (eye worm) hypothetical protein 0.0432 0.2688 0.8561
Entamoeba histolytica protein kinase, putative 0.0032 0.0122 0.2603
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0538 0.1692
Echinococcus granulosus vesicular acetylcholine transporter 0.0503 0.314 0.3555
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0209
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0624 0.2287
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.015 0.0518
Echinococcus multilocularis solute carrier family 22 0.0015 0.0012 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0032 0.0074
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0117 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0624 0.1988
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0124 0.042
Trypanosoma cruzi cruzipain precursor, putative 0.013 0.0754 0.2774
Loa Loa (eye worm) hypothetical protein 0.0066 0.0342 0.1091
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0036 0.0149 0.0448
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0067 0.0184
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.0754 0.2774
Brugia malayi Cathepsin L-like precursor 0.0034 0.0138 0.0412
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0138 0.0403
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0109 0.0123
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0047
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0294 0.1056
Echinococcus multilocularis transcription factor btf3 0.0034 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0032 0.0122 0.0387
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0012 0.0009
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0377 0.0377
Echinococcus multilocularis neuropeptide s receptor 0.046 0.2868 0.2868
Echinococcus granulosus neuropeptide s receptor 0.046 0.2868 0.3247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Onchocerca volvulus 0.0034 0.0138 0.0403
Mycobacterium ulcerans beta-lactamase 0.011 0.0624 1
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0066 0.098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0032 0.0324
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0087 0.0278
Echinococcus granulosus lamin 0.0026 0.0087 0.0099
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0067 0.0894
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0122 0.036
Schistosoma mansoni hypothetical protein 0.0047 0.022 0.0236
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0624 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0122 0.0387
Echinococcus multilocularis smad 0.0017 0.0025 0.0025
Entamoeba histolytica protein kinase, putative 0.0032 0.0122 0.2603
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0067 0.0204
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0122 0.0617
Schistosoma mansoni smad1 5 8 and 0.0017 0.0025 0.0015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Schistosoma mansoni metabotropic glutamate receptor 0.0033 0.0132 0.0136
Mycobacterium tuberculosis Conserved protein 0.011 0.0624 0.1387
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0122 0.0138
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0117 0.0117
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0538 0.1715
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Loa Loa (eye worm) hypothetical protein 0.011 0.0624 0.1988
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0138 0.0138
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0115 0.013
Echinococcus granulosus metabotropic glutamate receptor 5 0.0049 0.0232 0.0263
Onchocerca volvulus 0.0034 0.0138 0.0403
Onchocerca volvulus 0.0047 0.022 0.0667
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0031 0.0072
Onchocerca volvulus 0.011 0.0624 0.1957
Echinococcus granulosus solute carrier family 22 0.0015 0.0012 0.0013
Entamoeba histolytica hypothetical protein 0.0072 0.0377 1
Brugia malayi Cathepsin L-like precursor 0.0023 0.0066 0.0181
Echinococcus multilocularis General substrate transporter 0.0089 0.0488 0.0488
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0025 0.0028
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0294 0.032
Echinococcus multilocularis GPCR, family 2 0.0031 0.0115 0.0115
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0117 0.012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0032 0.0074
Trichomonas vaginalis esterase, putative 0.011 0.0624 1
Trypanosoma brucei glucose transporter 1E 0.0032 0.0124 0.042
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0122 0.0617
Mycobacterium leprae conserved hypothetical protein 0.011 0.0624 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Schistosoma mansoni transcription factor btf3 0.0034 0.0137 0.0142
Plasmodium vivax hypothetical protein, conserved 0.011 0.0624 0.2252
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0124 0.042
Leishmania major glucose transporter, lmgt1 0.0032 0.0124 0.042
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0067 0.0201
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0109 0.0109
Schistosoma mansoni metabotropic glutamate receptor 0.0019 0.0043 0.0035
Schistosoma mansoni hypothetical protein 0.0031 0.0115 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Schistosoma mansoni hypothetical protein 0.0103 0.0581 0.0645
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Onchocerca volvulus 0.011 0.0624 0.1957
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Brugia malayi intermediate filament protein 0.0026 0.0087 0.025
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Entamoeba histolytica hypothetical protein 0.0072 0.0377 1
Leishmania major basic transcription factor 3a, putative 0.0034 0.0137 0.0468
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0122 0.0138
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0124 0.042
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0138 0.0143
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0138 0.0143
Onchocerca volvulus 0.0026 0.0087 0.0241
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.015 0.0779
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0067 0.0067
Brugia malayi MH2 domain containing protein 0.0017 0.0025 0.0051
Loa Loa (eye worm) Smad1 0.0017 0.0025 0.0079
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0703 0.4425 1
Echinococcus granulosus solute carrier family 22 0.0015 0.0012 0.0013
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0137 0.0468
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0124 0.042
Schistosoma mansoni protein kinase 0.0032 0.0122 0.0124
Onchocerca volvulus 0.0034 0.0138 0.0403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0138 0.044
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.015 0.051
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0122 0.0404
Brugia malayi Cathepsin L-like precursor 0.0034 0.0138 0.0412
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0032 0.0074
Echinococcus granulosus microtubule associated protein 2 0.1392 0.8832 1
Plasmodium vivax vivapain-1 0.0018 0.0032 0.0073
Brugia malayi beta-lactamase 0.011 0.0624 0.1965
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0138 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0138 0.0403
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0432 0.2688 0.8557
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0032 0.0073
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0067 0.0308
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0032 0.0073
Loa Loa (eye worm) sugar transporter 0.0103 0.0581 0.1851
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0032 0.0022
Leishmania major C-8 sterol isomerase-like protein 0.0432 0.2688 1
Leishmania major cathepsin L-like protease 0.013 0.0754 0.2774
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0117 0.1262
Entamoeba histolytica hypothetical protein 0.0072 0.0377 1
Schistosoma mansoni hypothetical protein 0.0031 0.0115 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0067 0.0204
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.015 0.0518
Trypanosoma cruzi major cysteine proteinase, putative 0.0103 0.0575 0.2106
Onchocerca volvulus 0.0034 0.0138 0.0403
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0624 0.0694
Plasmodium vivax CDK-related protein kinase 6, putative 0.0439 0.273 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0012 0.0012
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0624 1
Schistosoma mansoni hypothetical protein 0.0072 0.0377 0.0414
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Plasmodium falciparum cysteine proteinase falcipain 1 0.0018 0.0032 0.0073
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0122 0.0404
Schistosoma mansoni smad 0.0017 0.0025 0.0015
Onchocerca volvulus 0.011 0.0624 0.1957
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.015 0.0518
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0138 0.0464
Schistosoma mansoni Smad4 0.0017 0.0025 0.0015
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0581 0.0581
Leishmania major cathepsin L-like protease 0.0034 0.0138 0.0471
Loa Loa (eye worm) hypothetical protein 0.0031 0.0115 0.0366
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0624 0.1387
Schistosoma mansoni protein kinase 0.0032 0.0122 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0624 1
Onchocerca volvulus 0.0034 0.0138 0.0403
Schistosoma mansoni glucose transport protein 0.0103 0.0581 0.0645
Loa Loa (eye worm) hypothetical protein 0.0049 0.0232 0.0739
Brugia malayi cathepsin L-like precursor 0.0023 0.0066 0.0181
Mycobacterium tuberculosis Conserved protein 0.011 0.0624 0.1387
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.1476 0.47
Brugia malayi MH2 domain containing protein 0.0017 0.0025 0.0051
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0624 0.1387
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0122 0.0387
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0067 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0581 0.0658
Loa Loa (eye worm) glutamate receptor 0.004 0.0173 0.0551
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0268
Plasmodium falciparum hexose transporter 0.0103 0.0581 0.2094
Loa Loa (eye worm) beta-lactamase 0.011 0.0624 0.1988
Echinococcus multilocularis cysteine protease 0.0034 0.0138 0.0138
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0624 0.1387
Echinococcus granulosus smad 0.0017 0.0025 0.0028
Echinococcus granulosus Smad4 0.0017 0.0025 0.0028
Trypanosoma brucei glucose transporter 2A 0.0032 0.0124 0.042
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0624 0.1387
Mycobacterium ulcerans lipase LipD 0.011 0.0624 1
Brugia malayi hypothetical protein 0.0015 0.0012 0.0009
Plasmodium vivax vivapain-2 0.0034 0.0138 0.0464
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0294 0.1589
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0581 0.0581
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0122 0.0404
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.0754 0.2774

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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