Detailed information for compound 82070

Basic information

Technical information
  • TDR Targets ID: 82070
  • Name: N-[4-hydroxy-3,5-di(propan-2-yl)phenyl]methan esulfonamide
  • MW: 271.376 | Formula: C13H21NO3S
  • H donors: 2 H acceptors: 3 LogP: 2.78 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1cc(cc(c1O)C(C)C)NS(=O)(=O)C)C
  • InChi: 1S/C13H21NO3S/c1-8(2)11-6-10(14-18(5,16)17)7-12(9(3)4)13(11)15/h6-9,14-15H,1-5H3
  • InChiKey: LABXQPNZMAWYTG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-hydroxy-3,5-diisopropyl-phenyl)methanesulfonamide
  • N-(4-hydroxy-3,5-diisopropylphenyl)methanesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ImpB/MucB/SamB family protein 0.0078 0.0253 0.156
Echinococcus granulosus microtubule associated protein 2 0.136 0.5373 1
Mycobacterium leprae Probable D-alanyl-D-alanine carboxypeptidase DacB1 (PENICILLIN-BINDING PROTEIN) (DD-PEPTIDASE) (DD-CARBOXYPEPTIDASE) (PBP) (DD-T 0.0129 0.0455 0.0801
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.0258 0.2261
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.011 0.1824
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0175 0.0322
Echinococcus granulosus CTD small phosphatase protein like 0.0024 0.0038 0.0071
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.007 0.0432
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0003 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.007 0.0616
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.2487 0.9874 1
Brugia malayi Bloom's syndrome protein homolog 0.0041 0.0105 0.0645
Leishmania major mitochondrial DNA polymerase beta 0.03 0.114 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0003 0.0024
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0055 0.0103
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.007 0.0616
Schistosoma mansoni 6-phosphofructokinase 0.0216 0.0806 0.1499
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0016 0.0007 0.0114
Giardia lamblia DINP protein human, muc B family 0.0059 0.0178 0.0796
Schistosoma mansoni chromobox protein 0.0069 0.0219 0.0407
Echinococcus granulosus bloom syndrome protein 0.0041 0.0105 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0113 0.0992
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0018 0.0033
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0175 0.2888
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0056 0.0167 0.0306
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0195 0.0722 0.1343
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0132
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.017 0.0619 0.5436
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0317 0.1209 0.2245
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0185 0.1627
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.1251 0.4939 0.9084
Loa Loa (eye worm) hypothetical protein 0.0026 0.0046 0.0286
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0065 0.0573
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0055 0.0339
Brugia malayi Phosphoglycerate kinase 0.0061 0.0185 0.1141
Chlamydia trachomatis transglycolase/transpeptidase 0.1078 0.4246 0.426
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0183 0.0672 0.294
Trypanosoma brucei unspecified product 0.0036 0.0087 0.0762
Plasmodium vivax SET domain protein, putative 0.006 0.0183 0.3019
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0176 0.1086
Toxoplasma gondii hypothetical protein 0.0048 0.0135 0.2224
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.011 0.0203
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0079 0.0148
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0018 0.0033
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0097 0.0522
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0175 0.0107
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0258 0.2261
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0024 0.0038 0.0091
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0024 0.0038 0.0628
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.011
Mycobacterium ulcerans DNA polymerase IV 0.0079 0.0258 0.0295
Mycobacterium ulcerans hypothetical protein 0.002 0.0021 0.0025
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0033 0.0546
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0024 0.0038 0.0628
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0021 0.0116
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0074 0.0137
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0236 0.0883 0.1592
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0038 0.0334
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0018 0.0033
Brugia malayi PXA domain containing protein 0.0019 0.0018 0.011
Echinococcus multilocularis jumonji domain containing protein 0.004 0.01 0.0186
Mycobacterium ulcerans hypothetical protein 0.0016 0.0007 0.0008
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0079 0.0148
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0018 0.0033
Treponema pallidum hypothetical protein 0.0317 0.1209 0.1147
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0164 0.101
Echinococcus granulosus peregrin 0.0032 0.0069 0.0129
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.2242 0.4125
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0055 0.0913
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0055 0.0909
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0258 0.2261
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0007 0.0061
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.017 0.0619 0.0709
Mycobacterium tuberculosis Probable reductase 0.0212 0.0789 0.1464
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0183 0.0672 0.4135
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0212 0.0789 0.1464
Schistosoma mansoni DNA polymerase eta 0.0078 0.0253 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0097 0.0178
Leishmania major phosphoglycerate kinase C, glycosomal 0.0166 0.0606 0.5316
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0096 0.043
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0056 0.0167 0.0306
Echinococcus granulosus chromobox protein 1 0.0069 0.0219 0.0407
Leishmania major DNA polymerase kappa, putative 0.0059 0.0178 0.1566
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0183 0.0672 0.1236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.2242 0.4125
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0055 0.0909
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0018 0.0033
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0317 0.1209 0.2194
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.011 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0033
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0021 0.0025
Chlamydia trachomatis transglycolase/transpeptidase 0.2487 0.9874 1
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0018 0.0033
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0074 0.0458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.007 0.0616
Trypanosoma brucei trypanothione reductase 0.0093 0.0313 0.2746
Schistosoma mansoni 6-phosphofructokinase 0.0216 0.0806 0.1499
Onchocerca volvulus Alhambra homolog 0.0028 0.0055 0.0298
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0164 0.2709
Leishmania major DNA polymerase kappa, putative 0.0016 0.0007 0.0061
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0003 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.2242 0.4125
Echinococcus granulosus lamin 0.0027 0.0048 0.009
Echinococcus granulosus dna polymerase kappa 0.0079 0.0258 0.048
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.1376 0.5435 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0234
Brugia malayi Pre-SET motif family protein 0.006 0.0183 0.1126
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0076 0.0246 0.0414
Chlamydia trachomatis D-alanine-D-alanine carboxypeptidase 0.006 0.0182 0.0114
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.0313 0.5165
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0055 0.0913
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0166 0.0606 0.5316
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0061 0.0113
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0258 0.2261
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0018 0.011
Mycobacterium ulcerans phosphoglycerate kinase 0.0166 0.0606 0.0694
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0164 0.144
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0258 0.2261
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0219 0.1347
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0236 0.0883 0.1639
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.1624 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0216 0.0806 0.1448
Trichomonas vaginalis dullard protein, putative 0.0024 0.0038 0.007
Wolbachia endosymbiont of Brugia malayi D-alanyl-D-alanine carboxypeptidase 0.0129 0.0455 0.0461
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0183 0.0672 0.294
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0238 0.0442
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0516 0.3177
Toxoplasma gondii small ubiquitin family modifier, putative 0.003 0.0061 0.1011
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0109 0.0586
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0094 0.156
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0166 0.0606 0.1124
Trichomonas vaginalis set domain proteins, putative 0.048 0.1857 0.3416
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0183 0.0672 0.1236
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0053 0.0152 0.0283
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0018 0.011
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.017 0.0619 0.1153
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0052 0.0095
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0175 0.0107
Leishmania major trypanothione reductase 0.0093 0.0313 0.2746
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0076 0.0246 0.1512
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0258 0.2261
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0058 0.0175 0.0322
Brugia malayi Pre-SET motif family protein 0.0421 0.1624 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0018 0.0033
Loa Loa (eye worm) 6-phosphofructokinase 0.0216 0.0806 0.4959
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0509 0.4462
Loa Loa (eye worm) SMO-1 protein 0.003 0.0061 0.0377
Echinococcus multilocularis 6 phosphofructokinase 0.0216 0.0806 0.1499
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.1251 0.4939 0.9167
Mycobacterium ulcerans penicillin-binding protein PbpA 0.1364 0.5388 0.617
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0212 0.0789 0.1464
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0003 0.0024
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.007 0.0616
Mycobacterium tuberculosis Probable penicillin-binding protein DacB2 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-t 0.0129 0.0455 0.0845
Echinococcus granulosus phosphoglycerate kinase 1 0.0166 0.0606 0.1128
Echinococcus granulosus 6 phosphofructokinase 0.0216 0.0806 0.1499
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0164 0.0302
Brugia malayi Heterochromatin protein 1 0.0069 0.0219 0.1347
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.017 0.0619 0.0709
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0164 0.0732
Loa Loa (eye worm) RecQ helicase 0.0041 0.0105 0.0645
Loa Loa (eye worm) glutathione reductase 0.0093 0.0313 0.1927
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.017 0.0619 0.3814
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0806 0.1482
Echinococcus multilocularis expressed protein 0.0372 0.1427 0.2657
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.2242 0.4125
Loa Loa (eye worm) 6-phosphofructokinase 0.0216 0.0806 0.4959
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0164 0.0095
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0806 0.1482
Brugia malayi 6-phosphofructokinase 0.0216 0.0806 0.4959
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0109 0.02
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0183 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0113 0.0992
Schistosoma mansoni microtubule-associated protein tau 0.136 0.5373 1
Trypanosoma brucei chrX additional, unordered contigs 0.0016 0.0007 0.0061
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.0185 0.1627
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0018 0.0033
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0195 0.0722 0.6333
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0806 0.1482
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0509 0.4462
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0164 0.0305
Schistosoma mansoni DNA polymerase IV / kappa 0.0016 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0166 0.0606 0.373
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0164 0.144
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0183 0.0672 0.0769
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0024 0.0038 0.0071
Toxoplasma gondii endonuclease IV APN 0.0076 0.0246 0.4053
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0003 0.0005
Chlamydia trachomatis endonuclease IV 0.0076 0.0246 0.0179
Echinococcus granulosus transcription factor Dp 1 0.0113 0.0393 0.0732
Toxoplasma gondii phosphofructokinase PFKII 0.0058 0.0175 0.2888
Schistosoma mansoni d-amino acid oxidase 0.0161 0.0584 0.1086
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0021 0.004
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0314 0.0585
Echinococcus multilocularis microtubule associated protein 2 0.136 0.5373 1
Giardia lamblia Phosphoglycerate kinase 0.0166 0.0606 0.2702
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0003 0.0005
Brugia malayi intermediate filament protein 0.0027 0.0048 0.0298
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0037 0.0604
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0024 0.0038 0.007
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0024 0.0038 0.007
Schistosoma mansoni hypothetical protein 0.0028 0.0055 0.0103
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0185 0.1627
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.1376 0.5435 0.6224
Loa Loa (eye worm) phosphofructokinase 0.0216 0.0806 0.4959
Plasmodium falciparum glutathione reductase 0.0032 0.007 0.1159
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.007 0.0131
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0039 0.0097 0.0597
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0003 0.0024
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0246 0.4053
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0071 0.0241
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0516 0.0961
Trypanosoma brucei unspecified product 0.0036 0.0087 0.0762
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0047 0.0087
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0024 0.0038 0.007
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.007 0.1159
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.011 0.1824
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0048 0.0298
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0164 0.0188
Loa Loa (eye worm) hypothetical protein 0.0161 0.0584 0.3593
Entamoeba histolytica phosphoglycerate kinase, putative 0.0166 0.0606 0.2644
Mycobacterium ulcerans glutaminase 0.0265 0.1001 0.1146
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0236 0.0883 0.1639
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0018 0.0033
Loa Loa (eye worm) acetyltransferase 0.0144 0.0516 0.3177
Schistosoma mansoni hypothetical protein 0.0024 0.0037 0.0069
Loa Loa (eye worm) hypothetical protein 0.0031 0.0063 0.039
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.011 0.0965
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0164 0.0166
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0183 0.0672 0.1236
Loa Loa (eye worm) glutaminase 0.0265 0.1001 0.6161
Plasmodium vivax DNA repair protein REV1, putative 0.0016 0.0007 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.007 0.0616
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0055 0.0103
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.007 0.0616
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0576 0.2242 1
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.007 0.1159
Trichomonas vaginalis conserved hypothetical protein 0.1376 0.5435 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0018 0.0033
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0055 0.0103
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0065 0.0573
Trypanosoma cruzi DNA polymerase eta, putative 0.0078 0.0253 0.2223
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.2201 0.8732 1
Plasmodium falciparum phosphoglycerate kinase 0.0166 0.0606 1
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0164 0.0302
Echinococcus multilocularis peregrin 0.0032 0.0069 0.0129
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0039 0.0641
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0018 0.0033
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.011 0.1824
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0018 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0112 0.0986
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0183 0.0672 0.2996
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0058 0.0175 0.0105
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0788 0.3087 0.5663
Entamoeba histolytica phosphofructokinase, putative 0.0216 0.0806 0.3542
Onchocerca volvulus 0.0031 0.0063 0.0341
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.2242 0.4125
Mycobacterium tuberculosis Probable penicillin-binding protein DacB1 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-t 0.0129 0.0455 0.0845
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0298
Trichomonas vaginalis glutaminase, putative 0.0265 0.1001 0.1841
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.011 0.0965
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0096 0.0353
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0195 0.0722 0.4443
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0175 0.0322
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0071 0.0626
Echinococcus multilocularis lamin 0.0027 0.0048 0.009
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0024 0.0038 0.0071
Leishmania major phosphoglycerate kinase B, cytosolic 0.0166 0.0606 0.5316
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0007 0.0061
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0018 0.011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.2242 0.4125
Leishmania major ATP-dependent phosphofructokinase 0.0216 0.0806 0.7069
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0058 0.0175 0.078
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0058 0.0175 0.0707
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0007 0.0061
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0024 0.0038 0.0628
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0258 0.2261
Echinococcus granulosus lamin dm0 0.0027 0.0048 0.009
Onchocerca volvulus 0.0027 0.0048 0.0261
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.1251 0.4939 0.5656
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0003 0.0005
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0216 0.0806 0.1495
Entamoeba histolytica ubiquitin like protein 0.003 0.0061 0.0195
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.007 0.1159
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0161 0.0584 0.0668
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0096 0.1591
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0258 0.2261
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0152 0.0938
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0055 0.0103
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.0313 0.2746
Echinococcus granulosus dna polymerase eta 0.0078 0.0253 0.0472
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0018 0.011
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0166 0.0606 1
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0007 0.0061
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.007 0.0616
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.011
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0055 0.0246
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.2242 0.4125
Brugia malayi hypothetical protein 0.0019 0.0018 0.011
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0185 0.1627
Trichomonas vaginalis DNA helicase recq1, putative 0.0041 0.0105 0.0193
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.114 1
Brugia malayi hypothetical protein 0.0019 0.0018 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0033
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0175 0.2888
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.05 0.0931
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0024 0.0038 0.017
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.007 0.0131
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0022 0.0029 0.0051
Trypanosoma brucei DNA polymerase eta, putative 0.0078 0.0253 0.2223
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0212 0.0789 0.1417
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0024 0.0038 0.0628
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0164 0.0658
Trichomonas vaginalis dullard protein, putative 0.0024 0.0038 0.007
Treponema pallidum penicillin-binding protein (pbp-2) 0.1376 0.5435 0.5403
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.011 0.0203
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0018 0.0033
Brugia malayi Thioredoxin reductase 0.0093 0.0313 0.1927
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0314 0.0585
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0216 0.0806 0.0741
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0048 0.0298
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0174 0.0324
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0018 0.011
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0055 0.0339
Mycobacterium tuberculosis Probable oxidoreductase 0.0236 0.0883 0.1639
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0147 0.053 0.0984
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0024 0.0038 0.0071
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.007 0.008
Trypanosoma brucei phosphoglycerate kinase 0.0166 0.0606 0.5316
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0195 0.0722 0.4443
Trypanosoma brucei phosphoglycerate kinase 0.0166 0.0606 0.5316
Plasmodium falciparum DNA repair protein REV1, putative 0.0016 0.0007 0.0114
Leishmania major hypothetical protein, conserved 0.0056 0.0167 0.1462
Schistosoma mansoni DNA helicase recq5 0.0028 0.0055 0.0103
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0281 0.1065 0.1977
Loa Loa (eye worm) glutaminase 2 0.0265 0.1001 0.6161
Plasmodium falciparum thioredoxin reductase 0.0093 0.0313 0.5165
Trichomonas vaginalis DNA helicase recq, putative 0.0041 0.0105 0.0193
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0018 0.011
Onchocerca volvulus 0.0183 0.0672 0.3617
Schistosoma mansoni glutaminase 0.0265 0.1001 0.1863
Trichomonas vaginalis DNA polymerase eta, putative 0.0079 0.0258 0.0474
Treponema pallidum penicillin-binding protein (pbp-1) 0.2487 0.9874 0.9873
Giardia lamblia Fructose-bisphosphate aldolase 0.0576 0.2242 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0018 0.0033
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.0178 0.1566
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0167 0.1462
Leishmania major DNA polymerase eta, putative 0.0078 0.0253 0.2223
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0561 0.2182 0.3991
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0178 0.1566
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.114 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0183 0.3019
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0212 0.0789 0.1464
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0033
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.007 0.0129
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0164 0.0305
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.0258 0.2261
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.011 0.0965
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0028 0.0055 0.0339
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0061 0.0538
Mycobacterium ulcerans epimerase 0.002 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.0027 0.0049 0.0302
Echinococcus multilocularis 0.0024 0.0038 0.0071
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.007 0.1159
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0212 0.0789 0.1464
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.007 0.0616
Echinococcus multilocularis Small ubiquitin modifier 2 0.003 0.0061 0.0114
Plasmodium vivax small ubiquitin-related modifier, putative 0.003 0.0061 0.1011
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0053 0.0152 0.0283
Trypanosoma brucei small ubiquitin-related modifier 0.003 0.0061 0.0538
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0195 0.0722 0.1343
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0258 0.2261
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0079 0.0148
Trypanosoma cruzi small ubiquitin protein, putative 0.003 0.0061 0.0538
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.007 0.0616
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0053 0.0152 0.0938
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.1364 0.5388 1
Entamoeba histolytica phosphofructokinase, putative 0.0216 0.0806 0.3542
Schistosoma mansoni lamin 0.0027 0.0048 0.009
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0018 0.0033
Giardia lamblia PHD finger protein 15 0.0028 0.0055 0.0247
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0166 0.0606 0.5316
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0219 0.0403
Plasmodium falciparum phd finger protein, putative 0.0028 0.0055 0.0913
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0166 0.0606 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0076 0.0246 0.1512
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0258 0.2261
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0033
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0185 0.1627
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0166 0.0606 0.1079
Schistosoma mansoni intermediate filament proteins 0.0027 0.0048 0.009
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0195 0.0722 0.6333
Echinococcus multilocularis expressed protein 0.0033 0.0074 0.0139
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0007 0.0061
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0018 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0018 0.0033
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0079 0.0258 0.0474
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0258 0.2261
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0161 0.0584 0.1038
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.114 1
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0166 0.0606 0.0614
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0024 0.0038 0.0071
Plasmodium falciparum glutathione reductase 0.0093 0.0313 0.5165
Trichomonas vaginalis rotamase, putative 0.0033 0.0074 0.0137
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.017 0.0619 0.1153
Plasmodium vivax phosphoglycerate kinase, putative 0.0166 0.0606 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0058 0.0175 0.2888
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0048 0.0298
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0003 0.0005
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0216 0.0806 0.7069
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0036 0.0222
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0147 0.1288
Echinococcus granulosus expressed protein 0.0372 0.1427 0.2657
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0183 0.034
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0065 0.0214
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0164 0.2709
Giardia lamblia DNA damage repair protein 0.0016 0.0007 0.0031
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.0313 0.1927
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0007 0.0061
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0175 0.2888
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0183 0.0672 0.1236
Schistosoma mansoni lamin 0.0027 0.0048 0.009
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0018 0.011
Brugia malayi polk-prov protein 0.0043 0.0112 0.0692
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0055 0.0103
Mycobacterium tuberculosis Probable dehydrogenase 0.0212 0.0789 0.1464
Echinococcus multilocularis dna polymerase kappa 0.0079 0.0258 0.048
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0219 0.0403
Schistosoma mansoni terminal deoxycytidyl transferase 0.0053 0.0152 0.0283
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0246 0.4053
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0018 0.011
Plasmodium falciparum thioredoxin reductase 0.0032 0.007 0.1159
Toxoplasma gondii thioredoxin reductase 0.0093 0.0313 0.5165
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0509 0.4462
Leishmania major DNA polymerase eta, putative 0.0042 0.0108 0.0948
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0788 0.3087 0.3535
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0055 0.0103
Brugia malayi PHD-finger family protein 0.0028 0.0055 0.034
Schistosoma mansoni phosphoglycerate kinase 0.0166 0.0606 0.1128
Mycobacterium ulcerans 6-phosphofructokinase 0.0216 0.0806 0.0923
Onchocerca volvulus 0.0072 0.0228 0.1229
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0055 0.0913
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0076 0.0246 0.0456
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0055 0.0909
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0055 0.0339
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.011
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.007 0.0616
Trichomonas vaginalis dullard protein, putative 0.0024 0.0038 0.007
Treponema pallidum serine-type D-Ala-D-Ala carboxypeptidase (dacC) 0.0129 0.0455 0.0388
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0024 0.0038 0.0234
Echinococcus granulosus jumonji domain containing protein 0.004 0.01 0.0186
Brugia malayi chromobox protein homolog 3 0.0039 0.0097 0.0597
Plasmodium falciparum small ubiquitin-related modifier 0.003 0.0061 0.1011
Echinococcus multilocularis lamin dm0 0.0027 0.0048 0.009
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0788 0.3087 0.573
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.007 0.1159
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.0313 0.0581
Echinococcus multilocularis transcription factor Dp 1 0.0113 0.0393 0.0732
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0164 0.0305
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0018 0.0033
Brugia malayi jmjC domain containing protein 0.0034 0.0079 0.0488
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0003 0.0017
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0071 0.0626
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0036 0.0222
Mycobacterium ulcerans penicillin-binding protein DacC 0.0129 0.0455 0.0521
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0195 0.0722 0.1343
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.007 0.008
Echinococcus multilocularis thioredoxin glutathione reductase 0.0093 0.0313 0.0582
Echinococcus multilocularis musashi 0.0027 0.0048 0.009
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0003 0.0045
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0018 0.0033
Schistosoma mansoni chromobox protein 0.0069 0.0219 0.0407
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0281 0.1065 0.1928
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0056 0.0167 0.1462
Brugia malayi Ubiquitin-like protein SMT3 0.003 0.0061 0.0377
Echinococcus granulosus expressed protein 0.0033 0.0074 0.0139
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0071 0.1177
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0175 0.0322
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0175 0.0322
Mycobacterium ulcerans endonuclease IV 0.0076 0.0246 0.0281
Toxoplasma gondii 6-phosphofructokinase 0.0058 0.0175 0.2888
Trichomonas vaginalis phosphofructokinase, putative 0.0216 0.0806 0.1482
Loa Loa (eye worm) hypothetical protein 0.0028 0.0055 0.034
Brugia malayi Phosphoglycerate kinase 0.0166 0.0606 0.373
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0183 0.0672 0.1236
Echinococcus multilocularis dna polymerase eta 0.0078 0.0253 0.0472
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0195 0.0722 0.6333
Onchocerca volvulus 0.048 0.1857 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0018 0.0033
Brugia malayi 6-phosphofructokinase 0.0216 0.0806 0.4959
Trichomonas vaginalis rotamase, putative 0.0033 0.0071 0.0131
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.017 0.0619 0.115
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0281 0.1065 0.122
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0561 0.2182 0.405
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0055 0.034
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0183 0.034
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0003 0.0045
Giardia lamblia Sentrin 0.003 0.0061 0.0273
Echinococcus granulosus thioredoxin glutathione reductase 0.0093 0.0313 0.0582
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.007 0.0616
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0232 0.2032
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0164 0.101
Plasmodium vivax glutathione reductase, putative 0.0093 0.0313 0.5165
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0158 0.0574 0.3533
Schistosoma mansoni rotamase 0.0033 0.0074 0.0139
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0055 0.0103
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.007 0.0131
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0043 0.0112 0.0692
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.007 0.0313
Echinococcus multilocularis chromobox protein 1 0.0069 0.0219 0.0407
Brugia malayi Bromodomain containing protein 0.0032 0.0069 0.0427
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.0185 0.1627
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0018 0.0033
Echinococcus multilocularis bloom syndrome protein 0.0041 0.0105 0.0195
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0175 0.0322
Onchocerca volvulus 0.0027 0.0048 0.0261
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0018 0.0033
Schistosoma mansoni ap endonuclease 0.0056 0.0164 0.0305
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0003 0.0005
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.007 0.0071
Mycobacterium ulcerans DNA polymerase IV 0.0079 0.0258 0.0295
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0164 0.144
Trypanosoma brucei unspecified product 0.0073 0.0232 0.2032
Brugia malayi jmjC domain containing protein 0.0093 0.0314 0.1934
Mycobacterium ulcerans D-alanyl-D-alanine carboxypeptidase 0.0129 0.0455 0.0521
Loa Loa (eye worm) hypothetical protein 0.0049 0.0137 0.0841
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0018 0.0033
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0183 0.0672 0.1236
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0183 0.034
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.007 0.013
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0018 0.0033
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0018 0.0033
Mycobacterium tuberculosis Conserved hypothetical protein 0.0053 0.0152 0.0283
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.007 0.0071
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0576 0.2242 1
Mycobacterium ulcerans hypothetical protein 0.0158 0.0573 0.0656
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.0573 0.1063
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0052 0.0095
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0516 0.0961
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0018 0.0033
Echinococcus granulosus geminin 0.0164 0.0598 0.1113
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0021 0.0132
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0175 0.0322
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.007 0.0616
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0018 0.011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.2242 0.4125
Brugia malayi glutathione reductase 0.0093 0.0313 0.1927
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0195 0.0722 0.3165
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.007 0.1159
Entamoeba histolytica deoxycytidyl transferase, putative 0.0053 0.0152 0.0605
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.007 0.0616
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.017 0.0619 0.1153
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0007 0.0061
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.007 0.0616
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0195 0.0722 0.6333
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0007 0.0061
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0071 0.0626
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0003 0.0017
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.011 0.0965
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0167 0.1462
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0074 0.0458
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0079 0.0148
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0065 0.0573
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0003 0.0045
Schistosoma mansoni hypothetical protein 0.0164 0.0598 0.1113
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0059 0.0178 0.0331
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0078 0.0253 0.156
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0108 0.0948
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0097 0.0178
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0175 0.2888
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.011
Echinococcus granulosus intermediate filament protein 0.0027 0.0048 0.009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.007 0.0616
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0024 0.0038 0.007
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.007 0.008
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0109 0.02
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0053 0.0152 0.0283
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0166 0.0606 0.1115
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.1364 0.5388 0.9913
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0018 0.0033
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.007 0.0616
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0442 0.1705 0.3165
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0112 0.0986
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0022 0.0029 0.013
Schistosoma mansoni ap endonuclease 0.0056 0.0164 0.0305
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0018 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0113 0.0992
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0185 0.1627
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0126 0.0447 0.0829
Echinococcus multilocularis geminin 0.0164 0.0598 0.1113
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0079 0.0488
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0164 0.144
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0003 0.0024
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0018 0.0033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0258 0.2261
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0183 0.0672 0.4135
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0018 0.0033
Leishmania major hypothetical protein, conserved 0.0024 0.0038 0.0334
Brugia malayi PXA domain containing protein 0.0019 0.0018 0.011
Schistosoma mansoni phosphoglycerate kinase 0.0166 0.0606 0.1128
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0258 0.2261
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.003 0.0061 0.0114
Echinococcus granulosus chromobox protein 1 0.0069 0.0219 0.0407
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0018 0.0033
Echinococcus granulosus Solute carrier family 22 5 0.1032 0.4062 0.756
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0216 0.0806 0.7069
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0065 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0018 0.0033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.007 0.0616
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0166 0.0606 0.1115
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0183 0.034
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0072 0.0228 0.0425
Treponema pallidum fructose-bisphosphate aldolase 0.0576 0.2242 0.2187
Echinococcus multilocularis chromobox protein 1 0.0069 0.0219 0.0407
Schistosoma mansoni hypothetical protein 0.0164 0.0598 0.1113
Schistosoma mansoni DNA helicase recq1 0.0028 0.0055 0.0103
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0003 0.0045
Brugia malayi phosphofructokinase 0.0216 0.0806 0.4959
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.011
Echinococcus multilocularis phosphoglycerate kinase 1 0.0166 0.0606 0.1128
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.007 0.0129
Loa Loa (eye worm) hypothetical protein 0.006 0.0183 0.1126
Leishmania major DNA damage repair protein, putative 0.0016 0.0007 0.0061
Entamoeba histolytica phosphofructokinase, putative 0.0216 0.0806 0.3542
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0108 0.1782
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0003 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0258 0.2261
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.0185 0.1627
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0071 0.0626
Leishmania major small ubiquitin protein, putative 0.003 0.0061 0.0538
Brugia malayi isocitrate dehydrogenase 0.0015 0.0003 0.0017
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0024 0.0038 0.0334
Chlamydia trachomatis phosphoglycerate kinase 0.0166 0.0606 0.0546
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0317 0.1209 0.1385
Echinococcus granulosus Small ubiquitin modifier 2 0.003 0.0061 0.0114
Toxoplasma gondii exonuclease III APE 0.0056 0.0164 0.2709
Brugia malayi glutaminase DH11.1 0.0265 0.1001 0.6161
Treponema pallidum phosphoglycerate kinase 0.0166 0.0606 0.0539
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0183 0.034

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 131 uM Inhibition of [35S]-TBPS binding to GABA-A receptor in rat cerebral cortex. ChEMBL. 9599235
IC50 (binding) = 131 uM Inhibition of [35S]-TBPS binding to GABA-A receptor in rat cerebral cortex. ChEMBL. 9599235
logP (ADMET) = 3.14 Partition coefficient (logP) ChEMBL. 9599235

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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