Detailed information for compound 827337

Basic information

Technical information
  • TDR Targets ID: 827337
  • Name: 3-(4-chlorophenyl)sulfonyl-6-ethyl-1-propylqu inolin-4-one
  • MW: 389.896 | Formula: C20H20ClNO3S
  • H donors: 0 H acceptors: 3 LogP: 5.02 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1cc(c(=O)c2c1ccc(c2)CC)S(=O)(=O)c1ccc(cc1)Cl
  • InChi: 1S/C20H20ClNO3S/c1-3-11-22-13-19(26(24,25)16-8-6-15(21)7-9-16)20(23)17-12-14(4-2)5-10-18(17)22/h5-10,12-13H,3-4,11H2,1-2H3
  • InChiKey: DQNSRDMAMSRZJS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-chlorophenyl)sulfonyl-6-ethyl-1-propyl-quinolin-4-one
  • 3-(4-chlorophenyl)sulfonyl-6-ethyl-1-propyl-4-quinolinone
  • 3-(4-chlorophenyl)sulfonyl-6-ethyl-1-propyl-4-quinolone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Immunoglobulin I-set domain containing protein 0.0203 0.0367 0.1152
Brugia malayi Fibronectin type III domain containing protein 0.0203 0.0367 0.1152
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0138 0.0229 0.0314
Schistosoma mansoni hypothetical protein 0.0043 0.003 0.002
Brugia malayi Cytochrome P450 family protein 0.0218 0.04 0.1265
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.003 0.0064
Echinococcus granulosus fibroblast growth factor receptor 4 0.0138 0.0229 0.0314
Toxoplasma gondii cytochrome p450 superfamily protein 0.0218 0.04 0.3485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0006 0.002
Brugia malayi hypothetical protein 0.0048 0.0039 0.004
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0047 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0376 0.0734 0.2397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0029 0.0099
Schistosoma mansoni nephrin 0.0051 0.0046 0.0035
Trypanosoma cruzi polo-like protein kinase, putative 0.1436 0.2978 1
Schistosoma mansoni cytochrome P450 0.0218 0.04 0.039
Loa Loa (eye worm) AUR protein kinase 0.0563 0.1129 0.3735
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0563 0.1129 0.377
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0051 0.0046 0.005
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0048 0.0039 0.0041
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0033
Brugia malayi Immunoglobulin I-set domain containing protein 0.1267 0.2621 0.8791
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0138 0.0229 0.0314
Loa Loa (eye worm) hypothetical protein 0.0245 0.0456 0.1455
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0045 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0199 0.0358 0.1123
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.333 0.6989 1
Entamoeba histolytica protein kinase, putative 0.0563 0.1129 0.377
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0218 0.04 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0007 0.0023
Brugia malayi serine/threonine-protein kinase 6 0.0563 0.1129 0.3735
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0024 0.0079
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.004
Loa Loa (eye worm) norepinephrine transporter 0.028 0.0531 0.1709
Echinococcus multilocularis lachesin 0.0047 0.0037 0.0037
Leishmania major protein kinase, putative 0.0563 0.1129 0.377
Onchocerca volvulus 0.0048 0.0039 0.004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.004
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0051 0.0046 0.005
Brugia malayi Peroxidasin 0.0047 0.0037 0.0035
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0046 0.0064
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0563 0.1129 1
Trypanosoma cruzi aurora B kinase, putative 0.0563 0.1129 0.377
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.004
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0051 0.0046 0.005
Echinococcus multilocularis peroxidasin 0.0047 0.0037 0.0038
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0037 0.0033
Schistosoma mansoni protein kinase 0.0563 0.1129 0.112
Mycobacterium leprae putative cytochrome p450 0.0218 0.04 0.5
Echinococcus granulosus integrin beta 2 0.0205 0.0372 0.0517
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0218 0.04 0.5
Trichomonas vaginalis CAMK family protein kinase 0.1436 0.2978 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0024 0.0079
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0563 0.1129 0.1603
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0037 0.0033
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0048 0.0039 0.0028
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0033
Echinococcus multilocularis roundabout 2 0.0051 0.0046 0.005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0037 0.0033
Toxoplasma gondii hypothetical protein 0.0048 0.0039 0.0253
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0221 0.0406 0.0566
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1267 0.2621 0.8791
Schistosoma mansoni cell adhesion molecule 0.0051 0.0046 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0024 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0053 0.0178
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.004
Entamoeba histolytica hypothetical protein 0.0043 0.003 0.0066
Loa Loa (eye worm) AUR protein kinase 0.0563 0.1129 0.3735
Brugia malayi Immunoglobulin I-set domain containing protein 0.0162 0.028 0.0859
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0047 0.0037 0.0026
Echinococcus granulosus tyrosine protein kinase otk 0.0047 0.0037 0.0037
Brugia malayi hypothetical protein 0.0043 0.003 0.0011
Echinococcus multilocularis sodium and chloride dependent glycine 0.0048 0.0039 0.0041
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0053 0.0043
Schistosoma mansoni tyrosine kinase 0.0138 0.0229 0.0219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0245 0.0456 0.1455
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0218 0.04 0.5
Echinococcus multilocularis hemicentin 1 0.0047 0.0037 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0218 0.04 0.5
Schistosoma mansoni titin 0.0047 0.0037 0.0026
Entamoeba histolytica hypothetical protein 0.0043 0.003 0.0066
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0218 0.04 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0024 0.0079
Echinococcus multilocularis roundabout 2 0.0051 0.0046 0.005
Giardia lamblia Kinase, PLK 0.1436 0.2978 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.004
Echinococcus granulosus sodium and chloride dependent glycine 0.0048 0.0039 0.0041
Schistosoma mansoni tyrosine kinase 0.0067 0.008 0.007
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0053 0.0061
Trichomonas vaginalis CAMK family protein kinase 0.1436 0.2978 1
Echinococcus granulosus roundabout 2 0.0051 0.0046 0.005
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0218 0.04 0.1314
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0563 0.1129 0.1603
Entamoeba histolytica hypothetical protein 0.0043 0.003 0.0066
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.004
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.0253
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.004
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0048 0.0039 0.0028
Trypanosoma cruzi cytochrome P450, putative 0.0362 0.0704 0.2338
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0053 0.0143
Echinococcus multilocularis serotonin transporter 0.028 0.0531 0.0746
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0053 0.0143
Echinococcus granulosus cytochrome P450 2K1 0.0218 0.04 0.0559
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0198 0.0358 0.0498
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0037 0.0033
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0047 0.0037 0.0033
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0053 0.0143
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0018 0.0007
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0218 0.04 0.1314
Loa Loa (eye worm) solute carrier family 6 member 4 0.028 0.0531 0.1709
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.004
Brugia malayi serine/threonine protein kinase 6 0.0563 0.1129 0.3735
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0065 0.0075 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0053 0.0178
Entamoeba histolytica protein kinase, putative 0.0563 0.1129 0.377
Echinococcus multilocularis integrin beta 2 0.0205 0.0372 0.0517
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0218 0.04 0.1314
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0035
Trypanosoma cruzi cytochrome P450, putative 0.0362 0.0704 0.2338
Schistosoma mansoni sodium/chloride dependent transporter 0.0048 0.0039 0.0028
Echinococcus multilocularis Immunoglobulin 0.0198 0.0358 0.0498
Trypanosoma cruzi polo-like protein kinase, putative 0.1436 0.2978 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0013 0.0042
Brugia malayi Cytochrome P450 family protein 0.0362 0.0704 0.2296
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.003 0.002
Echinococcus granulosus peroxidasin 0.0047 0.0037 0.0038
Schistosoma mansoni cell adhesion molecule 0.0047 0.0037 0.0026
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0053 0.0088
Schistosoma mansoni vesicular amine transporter 0.0198 0.0358 0.0348
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0045 0.0032 0.0031
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0051 0.0046 0.0064
Echinococcus granulosus roundabout 2 0.0051 0.0046 0.005
Brugia malayi serine/threonine kinase 12 0.0563 0.1129 0.3735
Loa Loa (eye worm) hypothetical protein 0.0144 0.0242 0.0729
Trichomonas vaginalis AGC family protein kinase 0.0563 0.1129 0.3791
Echinococcus multilocularis tyrosine protein kinase otk 0.0047 0.0037 0.0037
Trichomonas vaginalis AGC family protein kinase 0.0563 0.1129 0.3791
Brugia malayi Sodium:neurotransmitter symporter family protein 0.028 0.0531 0.1709
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0024 0.0079
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0037 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0218 0.04 0.5
Schistosoma mansoni roundabout 0.0047 0.0037 0.0026
Plasmodium falciparum transporter, putative 0.0048 0.0039 0.0253
Schistosoma mansoni sodium-dependent amino acid transporter 0.0048 0.0039 0.0028
Trichomonas vaginalis CAMK family protein kinase 0.1436 0.2978 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0006 0.002
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0218 0.04 0.5
Schistosoma mansoni sodium/chloride dependent transporter 0.028 0.0531 0.0521
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0048 0.0039 0.0041
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0046 0.0064
Loa Loa (eye worm) hypothetical protein 0.028 0.0531 0.1709
Brugia malayi Cytochrome P450 family protein 0.0362 0.0704 0.2296
Loa Loa (eye worm) TK protein kinase 0.0162 0.028 0.0859
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.0253
Loa Loa (eye worm) AUR protein kinase 0.0563 0.1129 0.3735
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0203 0.0367 0.1152
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0048 0.0039 0.0041
Echinococcus multilocularis hemicentin 1 0.0047 0.0037 0.0037
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.333 0.6989 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0053 0.0143
Echinococcus granulosus defective proboscis extension response 0.0198 0.0358 0.0498
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0563 0.1129 0.377
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0218 0.04 0.5
Schistosoma mansoni sodium/chloride dependent transporter 0.0061 0.0068 0.0057
Echinococcus granulosus sodium and chloride dependent glycine 0.0048 0.0039 0.0041
Echinococcus granulosus aurora kinase A 0.0563 0.1129 0.1603
Echinococcus multilocularis twitchin 0.0038 0.0018 0.0011
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.1436 0.2978 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0053 0.0178
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0198 0.0358 0.0348
Entamoeba histolytica protein kinase , putative 0.0563 0.1129 0.377
Trichomonas vaginalis CAMK family protein kinase 0.1436 0.2978 1
Trichomonas vaginalis AGC family protein kinase 0.0563 0.1129 0.3791
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.004
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0048 0.0039 0.0041
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0051 0.0046 0.005
Loa Loa (eye worm) hypothetical protein 0.0198 0.0358 0.1121
Schistosoma mansoni integrin beta subunit 0.0163 0.0283 0.0272
Leishmania major cytochrome p450-like protein 0.0218 0.04 0.1314
Echinococcus multilocularis roundabout 2 0.0249 0.0465 0.0652
Trypanosoma brucei cytochrome P450, putative 0.0362 0.0704 0.2338
Echinococcus granulosus contactin 0.0051 0.0046 0.005
Loa Loa (eye worm) cytochrome P450 family protein 0.0882 0.1805 0.6026
Echinococcus granulosus serine:threonine protein kinase PLK1 0.1436 0.2978 0.4252
Loa Loa (eye worm) integrin beta-2 0.0276 0.0523 0.1682
Loa Loa (eye worm) hypothetical protein 0.028 0.0531 0.1709
Leishmania major cytochrome p450-like protein 0.0362 0.0704 0.2338
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0218 0.04 0.5
Loa Loa (eye worm) CYP4Cod1 0.0362 0.0704 0.2296
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0048 0.0039 0.5
Echinococcus multilocularis sodium and chloride dependent glycine 0.0048 0.0039 0.0041
Mycobacterium leprae Conserved hypothetical protein 0.0218 0.04 0.5
Loa Loa (eye worm) cytochrome P450 0.0218 0.04 0.1265
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0218 0.04 0.5
Echinococcus granulosus roundabout 2 0.0249 0.0465 0.0652
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.003 0.0064
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0218 0.04 0.5
Brugia malayi serine/threonine-protein kinase plk-2 0.1436 0.2978 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.0037 0.0033
Echinococcus granulosus hemicentin 1 0.0047 0.0037 0.0037
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0053 0.0143
Brugia malayi Prion-like- 0.0047 0.0037 0.0033
Schistosoma mansoni cell adhesion molecule 0.0051 0.0046 0.0035
Schistosoma mansoni hypothetical protein 0.0218 0.04 0.039
Brugia malayi Cytochrome P450 family protein 0.0882 0.1805 0.6026
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0043 0.0028 0.0004
Onchocerca volvulus 0.1026 0.211 0.706
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0198 0.0358 0.0348
Trichomonas vaginalis CAMK family protein kinase 0.1436 0.2978 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.028 0.0531 0.0521
Echinococcus granulosus neuroglian 0.0051 0.0046 0.005
Giardia lamblia Aurora kinase 0.0563 0.1129 0.3679
Trypanosoma brucei polo-like protein kinase 0.1436 0.2978 1
Loa Loa (eye worm) hypothetical protein 0.028 0.0531 0.1709
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0048 0.0039 0.0041
Echinococcus granulosus neuroglian 0.0222 0.0409 0.0571
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.003 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0007 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0029 0.0099
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0029 0.0099
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0048 0.0039 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0024 0.0079
Loa Loa (eye worm) hypothetical protein 0.0198 0.0358 0.1121
Onchocerca volvulus 0.0048 0.0039 0.004
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0218 0.04 0.5
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0218 0.04 0.1314
Loa Loa (eye worm) cytochrome P450 family protein 0.0362 0.0704 0.2296
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0048 0.0039 0.0028
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0053 0.0088
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0218 0.04 0.5
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0138 0.0229 0.0314
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.1436 0.2978 1
Trichomonas vaginalis CAMK family protein kinase 0.1436 0.2978 1
Echinococcus multilocularis 0.0218 0.04 0.0559
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0362 0.0704 1
Brugia malayi hypothetical protein 0.0376 0.0734 0.2397
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0048 0.0039 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0218 0.04 0.5
Brugia malayi hypothetical protein 0.0203 0.0367 0.1152
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0053 0.0143
Onchocerca volvulus 0.028 0.0531 0.1709
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0218 0.04 0.5
Schistosoma mansoni cell adhesion molecule 0.0225 0.0415 0.0405
Brugia malayi cytochrome P450 0.0218 0.04 0.1265
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0024 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.1436 0.2978 0.297
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0053 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0036 0.0121
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0563 0.1129 0.377
Echinococcus granulosus lachesin 0.0047 0.0037 0.0037
Onchocerca volvulus Tyrosine kinase homolog 0.107 0.2204 0.7379
Schistosoma mansoni titin 0.0042 0.0027 0.0016
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0048 0.0039 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0029 0.0099
Treponema pallidum sodium- and chloride- dependent transporter 0.028 0.0531 0.5
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0218 0.04 0.1314
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0051 0.0046 0.0035
Entamoeba histolytica protein kinase domain containing protein 0.0563 0.1129 0.377
Schistosoma mansoni septate junction protein 0.0047 0.0037 0.0026
Schistosoma mansoni septate junction protein 0.0047 0.0037 0.0026
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.003 0.0028
Schistosoma mansoni nephrin 0.0227 0.0418 0.0408
Loa Loa (eye worm) hypothetical protein 0.0051 0.0046 0.0064
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.003 0.0064
Onchocerca volvulus Serine\/threonine kinase homolog 0.1436 0.2978 1
Loa Loa (eye worm) serotonin transporter b 0.028 0.0531 0.1709
Plasmodium falciparum amino acid transporter, putative 0.0048 0.0039 0.0253
Trichomonas vaginalis AGC family protein kinase 0.0563 0.1129 0.3791
Loa Loa (eye worm) hypothetical protein 0.0221 0.0406 0.1283
Loa Loa (eye worm) TK/ROR protein kinase 0.0045 0.0032 0.0018
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.1436 0.2978 0.4252
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0053 0.0143
Echinococcus granulosus titin 0.0042 0.0027 0.0024
Echinococcus multilocularis neuroglian 0.0051 0.0046 0.005
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0024 0.0116
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0218 0.04 0.5
Trichomonas vaginalis CAMK family protein kinase 0.1436 0.2978 1
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0027 0.0016
Echinococcus multilocularis titin 0.0042 0.0027 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0563 0.1129 0.112
Echinococcus granulosus serotonin transporter 0.028 0.0531 0.0746
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0048 0.0039 0.0028
Leishmania major cytochrome p450-like protein 0.0218 0.04 0.1314
Echinococcus granulosus twitchin 0.0236 0.0438 0.0612
Trypanosoma brucei aurora B kinase 0.0563 0.1129 0.377
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0218 0.04 0.5
Echinococcus granulosus titin 0.0042 0.0027 0.0024
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.0037 0.0033
Loa Loa (eye worm) cytochrome P450 family protein 0.0362 0.0704 0.2296
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0218 0.04 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0028 0.0004
Loa Loa (eye worm) hypothetical protein 0.0203 0.0367 0.1152
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0048 0.0039 0.0041
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0048 0.0039 0.0028
Brugia malayi Integrin beta pat-3 precursor 0.0276 0.0523 0.1682
Echinococcus multilocularis aurora kinase A 0.0563 0.1129 0.1603
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.0037 0.0033
Echinococcus multilocularis neuroglian 0.0222 0.0409 0.0571
Plasmodium falciparum serine/threonine protein kinase, putative 0.0563 0.1129 1
Toxoplasma gondii hypothetical protein 0.0048 0.0039 0.0253
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0048 0.0039 0.0028
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0048 0.0039 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0015 0.0051
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0053 0.0061
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0051 0.0046 0.005
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0218 0.04 0.5
Echinococcus granulosus Immunoglobulin 0.0198 0.0358 0.0498
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0218 0.04 0.5
Toxoplasma gondii aurora kinase 0.0563 0.1129 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.1436 0.2978 1
Echinococcus multilocularis Immunoglobulin 0.0198 0.0358 0.0498
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0033
Entamoeba histolytica hypothetical protein 0.0043 0.003 0.0066
Loa Loa (eye worm) hypothetical protein 0.0047 0.0037 0.0033
Onchocerca volvulus 0.0048 0.0039 0.004
Loa Loa (eye worm) hypothetical protein 0.0203 0.0367 0.1152
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0048 0.0039 0.004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0046 0.0064
Schistosoma mansoni neuroglian 0.0051 0.0046 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0029 0.0099

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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