Detailed information for compound 83668

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 333.429 | Formula: C17H27N5O2
  • H donors: 2 H acceptors: 3 LogP: 3.53 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)NC1CCCCC1
  • InChi: 1S/C17H27N5O2/c1-3-10-21-14-13(15(23)22(11-4-2)17(21)24)19-16(20-14)18-12-8-6-5-7-9-12/h12H,3-11H2,1-2H3,(H2,18,19,20)
  • InChiKey: NYRQDQZPNUIGHI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References
Rattus norvegicus Adenosine A2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Adenosine A2 receptor   410 aa 346 aa 28.3 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Adenosine A2 receptor   410 aa 366 aa 25.4 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Adenosine A2 receptor   410 aa 342 aa 23.1 %
Echinococcus granulosus thyrotropin releasing hormone receptor Adenosine A2 receptor   410 aa 342 aa 23.1 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A2 receptor   410 aa 352 aa 23.6 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Adenosine A2 receptor   410 aa 340 aa 27.9 %
Echinococcus granulosus allatostatin A receptor Adenosine A2 receptor   410 aa 368 aa 22.6 %
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Schistosoma mansoni biogenic amine (5HT) receptor Adenosine A2 receptor   410 aa 399 aa 28.1 %
Echinococcus multilocularis allatostatin A receptor Adenosine A2 receptor   410 aa 372 aa 22.8 %
Onchocerca volvulus Adenosine A2 receptor   410 aa 356 aa 23.9 %
Onchocerca volvulus Adenosine A2 receptor   410 aa 337 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0333 0.0705
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0079 0.008
Echinococcus granulosus calcium dependent protein kinase 0.0062 0.0552 0.0556
Brugia malayi Cation transporter family protein 0.0014 0.0027 0.0057
Plasmodium vivax hexose transporter 0.0436 0.4725 0.4725
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0027 0.0057
Loa Loa (eye worm) hypothetical protein 0.0109 0.1082 0.2102
Toxoplasma gondii protein kinase, putative 0.0606 0.6612 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.0399 0.0844
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0027 0.0057
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0061 0.0549 1
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0019 0.0079 0.0579
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0331 0.0333
Echinococcus multilocularis solute carrier family 22 0.0061 0.0549 0.0553
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0046 0.0376 0.0379
Echinococcus multilocularis G protein coupled receptor 139 0.0046 0.0376 0.0379
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0376 0.0379
Echinococcus granulosus dro:myosuppressin receptor 0.0046 0.0376 0.0379
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.0399 0.0603
Echinococcus granulosus neuropeptide receptor 0.0046 0.0376 0.0379
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0597 0.1263
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.0399 0.0402
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0161 0.0161
Echinococcus multilocularis dna polymerase eta 0.0015 0.003 0.003
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0039 0.0302 0.0304
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Plasmodium falciparum flap endonuclease 1 0.0026 0.0161 0.0161
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0119 0.2978
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0094
Trypanosoma brucei glucose transporter, putative 0.0135 0.1373 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0376 0.0796
Onchocerca volvulus 0.0046 0.0376 0.6686
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0331 0.2409
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0088 0.0133
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0376 0.0796
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0079 0.0154
Leishmania major glucose transporter, lmgt2 0.0135 0.1373 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0104 0.0759
Onchocerca volvulus 0.0046 0.0376 0.6686
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0273 0.1991
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0376 0.0796
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0161 0.0162
Brugia malayi neuropeptide F receptor 0.0046 0.0376 0.0796
Echinococcus granulosus peptide allatostatin:somatostatin 0.0046 0.0376 0.0379
Brugia malayi G protein-coupled receptor 0.0046 0.0376 0.0796
Brugia malayi hypothetical protein 0.0046 0.0376 0.0796
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.0602
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0046 0.0376 0.0796
Echinococcus granulosus Sugar transporter ERD6 protein 0.0061 0.0549 0.0553
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Echinococcus granulosus solute carrier family 22 0.0061 0.0549 0.0553
Trypanosoma brucei THT1 - hexose transporter, putative 0.0135 0.1373 1
Plasmodium vivax DNA polymerase alpha, putative 0.0019 0.0079 0.0079
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0161 0.1169
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0273 0.0276
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0039 0.0302 0.0304
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Schistosoma mansoni neuropeptide f receptor 76f 0.0046 0.0376 0.0796
Treponema pallidum ATP-dependent DNA helicase 0.002 0.0088 0.0277
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0376 0.0379
Trypanosoma brucei unspecified product 0.0035 0.0256 0.1864
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0825 0.9047 0.9121
Schistosoma mansoni biogenic amine (5HT) receptor 0.0176 0.1821 0.3853
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0014 0.0027 0.0057
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.0376 0.0379
Schistosoma mansoni nAChR subunit 0.0014 0.0027 0.0057
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Echinococcus granulosus fmrfamide receptor 0.0046 0.0376 0.0379
Onchocerca volvulus 0.0061 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0302 0.0587
Plasmodium falciparum calcium-dependent protein kinase 2 0.0066 0.0597 0.0597
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0046 0.0376 0.0796
Loa Loa (eye worm) hypothetical protein 0.0061 0.0549 0.1066
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0019 0.0079 0.008
Trichomonas vaginalis sugar transporter, putative 0.0135 0.1373 0.2905
Echinococcus multilocularis allatostatin A receptor 0.0046 0.0376 0.0379
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0364 0.2654
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0376 0.0379
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0273 0.1107
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0347 0.3724 0.5632
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0014 0.0027 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0549 0.1162
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0019 0.0079 0.0079
Echinococcus granulosus glycine receptor subunit beta 0.0014 0.0027 0.0027
Echinococcus multilocularis dro:myosuppressin receptor 0.0046 0.0376 0.0379
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0582 0.1232
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0014 0.0027 0.0027
Schistosoma mansoni flap endonuclease-1 0.0024 0.0132 0.028
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.1482 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0331 0.2409
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.3175 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0027 0.0057
Schistosoma mansoni protein kinase 0.0066 0.0597 0.1263
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0046 0.0376 0.073
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0046 0.0376 0.0796
Brugia malayi hypothetical protein 0.0046 0.0376 0.0796
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0044 0.0045
Trichomonas vaginalis DNA helicase recq, putative 0.0066 0.0603 0.1277
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0014 0.0027 0.0052
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0318 0.1289
Loa Loa (eye worm) hypothetical protein 0.0061 0.0549 0.1066
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0273 0.1107
Giardia lamblia Hexose transporter 0.0061 0.0549 0.1444
Schistosoma mansoni histamine h1 receptor 0.0046 0.0376 0.0796
Onchocerca volvulus 0.0061 0.0549 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Trypanosoma brucei sugar transporter, putative 0.0061 0.0549 0.3999
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0331 0.2409
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0436 0.4725 0.4764
Loa Loa (eye worm) hypothetical protein 0.0061 0.0549 0.1066
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0019 0.0079 0.0168
Plasmodium vivax CDK-related protein kinase 6, putative 0.091 1 1
Schistosoma mansoni hypothetical protein 0.0046 0.0376 0.0796
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0046 0.0376 0.073
Loa Loa (eye worm) melatonin receptor type 1A 0.0046 0.0376 0.073
Schistosoma mansoni glucose transporter 0.0061 0.0549 0.1162
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0436 0.4725 0.4764
Toxoplasma gondii sugar transporter ST1 0.0061 0.0549 0.083
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0046 0.0376 0.0379
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0079 0.008
Brugia malayi putative neuropeptide receptor 0.0046 0.0376 0.0796
Schistosoma mansoni sugar transporter 0.0061 0.0549 0.1162
Schistosoma mansoni DNA helicase recq1 0.0039 0.0302 0.0639
Schistosoma mansoni glucose transport protein 0.0436 0.4725 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.0399 0.2689
Echinococcus granulosus solute carrier family 22 0.0061 0.0549 0.0553
Echinococcus granulosus synaptic vesicle 2 protein 0.0061 0.0549 0.0553
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Onchocerca volvulus 0.0019 0.0079 0.101
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0019 0.0079 0.0579
Trypanosoma brucei glucose transporter 1E 0.0135 0.1373 1
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0019 0.0079 0.008
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0273 0.1107
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0218 0.1585
Plasmodium falciparum calcium-dependent protein kinase 5 0.0066 0.0597 0.0597
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0046 0.0376 0.0796
Brugia malayi hypothetical protein 0.0046 0.0376 0.0796
Echinococcus granulosus dna polymerase eta 0.0015 0.003 0.003
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0019 0.0079 0.0579
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0014 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.0399 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0582 0.1232
Trypanosoma cruzi hexose transporter, putative 0.0061 0.0549 0.3999
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Brugia malayi Cation transporter family protein 0.0014 0.0027 0.0057
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0061 0.0549 0.1162
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.0376 0.0379
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0376 0.0379
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0331 0.2409
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.003 0.012
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0014 0.0027 0.0057
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0119 0.0374
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0273 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0273 0.0578
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Leishmania major myo-inositol/proton symporter (MIT) 0.0061 0.0549 0.3999
Loa Loa (eye worm) hypothetical protein 0.0037 0.0273 0.0531
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0053 0.0389
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0061 0.0549 0.3999
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0376 0.0379
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.043 0.091
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0331 0.07
Trichomonas vaginalis glucose transporter, putative 0.0135 0.1373 0.2905
Onchocerca volvulus 0.0037 0.0273 0.4722
Schistosoma mansoni polycystin 1-related 0.0019 0.0079 0.0168
Echinococcus granulosus RUN 0.0019 0.0079 0.008
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Echinococcus granulosus transcription factor eb 0.011 0.1088 0.1097
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0094
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0079 0.0079
Brugia malayi hypothetical protein 0.0046 0.0376 0.0796
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Trypanosoma cruzi glucose transporter, putative 0.0061 0.0549 0.3999
Loa Loa (eye worm) ACC-1 protein 0.0014 0.0027 0.0052
Leishmania major glucose transporter, lmgt1 0.0135 0.1373 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0319 0.0482
Mycobacterium tuberculosis Conserved protein 0.0037 0.0273 0.1107
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0046 0.0376 0.0379
Plasmodium falciparum calcium-dependent protein kinase 4 0.0066 0.0597 0.0597
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.0376 0.0379
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0079 0.008
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0019 0.0079 0.0168
Loa Loa (eye worm) hypothetical protein 0.0061 0.0549 0.1066
Onchocerca volvulus 0.0046 0.0376 0.6686
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0302 0.0639
Echinococcus multilocularis somatostatin receptor 0.0046 0.0376 0.0379
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Onchocerca volvulus 0.0061 0.0549 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0066 0.0597 0.4348
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0014 0.0027 0.0057
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0273 0.1107
Schistosoma mansoni sugar transporter 0.0061 0.0549 0.1162
Loa Loa (eye worm) hypothetical protein 0.0176 0.1821 0.3537
Onchocerca volvulus 0.0046 0.0376 0.6686
Brugia malayi larval opioid receptor 0.0046 0.0376 0.0796
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0399 0.2689
Brugia malayi lysyl-tRNA synthetase 0.0048 0.0399 0.0844
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3175 0.6719
Trichomonas vaginalis sugar transporter, putative 0.0135 0.1373 0.2905
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0436 0.4725 0.4764
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0436 0.4725 0.4764
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.003 0.0063
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.003 0.0215
Trichomonas vaginalis sugar transport protein, putative 0.0061 0.0549 0.1162
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0376 0.0379
Onchocerca volvulus 0.0046 0.0376 0.6686
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0014 0.0027 0.0057
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0376 0.0379
Mycobacterium ulcerans integral membrane transport protein 0.0061 0.0549 0.3704
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Schistosoma mansoni hypothetical protein 0.0436 0.4725 1
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0019 0.0079 0.012
Echinococcus granulosus orexin receptor type 2 0.0046 0.0376 0.0379
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0079 0.008
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Trichomonas vaginalis esterase, putative 0.0037 0.0273 0.0578
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0061 0.0549 0.2222
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0549 0.1162
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0376 0.0796
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0088 0.0642
Echinococcus granulosus solute carrier family 22 0.0061 0.0549 0.0553
Brugia malayi Tachykinin-like peptides receptor 99D 0.0046 0.0376 0.0796
Echinococcus granulosus 7TM GPCR rhodopsin 0.0046 0.0376 0.0379
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0347 0.3724 0.3724
Echinococcus multilocularis neuropeptide s receptor 0.0046 0.0376 0.0379
Plasmodium falciparum calcium-dependent protein kinase 1 0.0066 0.0597 0.0597
Loa Loa (eye worm) sugar transporter 0.0436 0.4725 0.9179
Onchocerca volvulus 0.0046 0.0376 0.6686
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0014 0.0027 0.0057
Entamoeba histolytica hypothetical protein 0.0101 0.0986 0.2592
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0376 0.0379
Trypanosoma brucei glucose transporter, putative 0.0135 0.1373 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0046 0.0376 0.0379
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0014 0.0027 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0376 0.0379
Echinococcus multilocularis sex peptide receptor 0.0046 0.0376 0.0379
Loa Loa (eye worm) hypothetical protein 0.0061 0.0549 0.1066
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0376 0.073
Trichomonas vaginalis conserved hypothetical protein 0.0436 0.4725 1
Trypanosoma cruzi hexose transporter 0.0135 0.1373 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0046 0.0376 0.6686
Giardia lamblia DINP protein human, muc B family 0.0021 0.0104 0.0274
Schistosoma mansoni blooms syndrome DNA helicase 0.0046 0.0381 0.0806
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0582 0.0587
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0376 0.0379
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0376 0.0379
Echinococcus granulosus solute carrier family 22 0.0061 0.0549 0.0553
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0161 0.034
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.0602
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0331 0.2409
Trichomonas vaginalis myo-inositol transporter, putative 0.0061 0.0549 0.1162
Onchocerca volvulus 0.0061 0.0549 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0376 0.0379
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0014 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Brugia malayi Sugar transporter family protein 0.0061 0.0549 0.1162
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0027 0.0057
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0039 0.0302 0.0302
Schistosoma mansoni hypothetical protein 0.0046 0.0376 0.0796
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0701 0.5104
Echinococcus multilocularis glycine receptor subunit beta 0.0014 0.0027 0.0027
Brugia malayi hypothetical protein 0.0061 0.0549 0.1162
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0014 0.0027 0.0027
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0436 0.4725 0.4764
Onchocerca volvulus 0.0061 0.0549 1
Brugia malayi Flap endonuclease-1 0.0026 0.0161 0.034
Schistosoma mansoni glucose transport protein 0.0436 0.4725 1
Echinococcus granulosus bloom syndrome protein 0.0066 0.0603 0.0608
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0079 0.008
Brugia malayi Bloom's syndrome protein homolog 0.0066 0.0603 0.1277
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0376 0.0379
Brugia malayi beta-lactamase family protein 0.0037 0.0273 0.0578
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0046 0.0376 0.073
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0376 0.0379
Onchocerca volvulus 0.0046 0.0376 0.6686
Echinococcus multilocularis solute carrier family 22 0.0061 0.0549 0.0553
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0014 0.0027 0.0057
Echinococcus granulosus G protein coupled receptor 139 0.0046 0.0376 0.0379
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Toxoplasma gondii DNA polymerase 0.0019 0.0079 0.012
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0014 0.0027 0.0027
Onchocerca volvulus 0.0061 0.0549 1
Brugia malayi neuropeptide F receptor 0.0046 0.0376 0.0796
Loa Loa (eye worm) hypothetical protein 0.0037 0.0273 0.0531
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0376 0.0379
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0376 0.0379
Schistosoma mansoni lipoxygenase 0.0115 0.1145 0.2422
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0046 0.0376 0.0379
Brugia malayi putative neuropeptide receptor NPR1 0.0046 0.0376 0.0796
Schistosoma mansoni opsin-like receptor 0.0046 0.0376 0.0796
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0701 0.5104
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0014 0.0027 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0273 0.1991
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0273 0.1844
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Schistosoma mansoni amine GPCR 0.0046 0.0376 0.0796
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0701 0.5104
Trypanosoma brucei THT1 - hexose transporter, putative 0.0135 0.1373 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0014 0.0027 0.0057
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.0376 0.0379
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0014 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0037 0.0273 0.0531
Loa Loa (eye worm) hypothetical protein 0.0052 0.0448 0.087
Loa Loa (eye worm) hypothetical protein 0.0061 0.0549 0.1066
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0376 0.0379
Schistosoma mansoni amine GPCR 0.0046 0.0376 0.0796
Trichomonas vaginalis glucose transporter, putative 0.0061 0.0549 0.1162
Loa Loa (eye worm) sugar transporter 0.0061 0.0549 0.1066
Echinococcus multilocularis bloom syndrome protein 0.0066 0.0603 0.0608
Loa Loa (eye worm) hypothetical protein 0.0061 0.0549 0.1066
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0376 0.0379
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0046 0.0376 0.0379
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0331 0.2409
Echinococcus multilocularis g-protein coupled receptor 0.0046 0.0376 0.0379
Leishmania major DNA polymerase kappa, putative 0.0021 0.0104 0.0759
Brugia malayi RE15519p 0.0046 0.0376 0.0796
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Brugia malayi excitatory GABA receptor EXP-1A 0.0014 0.0027 0.0057
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0019 0.0079 0.0079
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.1482 1
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0597 0.1263
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0582 0.1531
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0376 0.0796
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0019 0.0079 0.0209
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.0057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0376 0.0796
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.3175 0.8351
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.0399 0.1048
Entamoeba histolytica protein kinase, putative 0.0066 0.0597 0.157
Schistosoma mansoni hypothetical protein 0.0172 0.1784 0.3776
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0079 0.0579
Brugia malayi major facilitator superfamily protein 0.0061 0.0549 0.1162
Brugia malayi beta-lactamase 0.0037 0.0273 0.0578
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0041 0.0318 0.1289
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0019 0.0079 0.0168
Brugia malayi Dopamine receptor protein 1 0.0046 0.0376 0.0796
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0302 0.0457
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0399 0.2689
Echinococcus multilocularis synaptic vesicle 2 protein 0.0061 0.0549 0.0553
Echinococcus granulosus g protein coupled receptor 0.0046 0.0376 0.0379
Echinococcus multilocularis neuropeptide FF receptor 2 0.0046 0.0376 0.0379
Schistosoma mansoni neuropeptide receptor 0.0046 0.0376 0.0796
Toxoplasma gondii transporter, major facilitator family protein 0.0061 0.0549 0.083
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0066 0.0597 0.0597
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0061 0.0549 0.2222
Entamoeba histolytica recQ family helicase, putative 0.0045 0.0364 0.0958
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Onchocerca volvulus 0.0046 0.0376 0.6686
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Loa Loa (eye worm) hypothetical protein 0.0066 0.0597 0.1159
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0066 0.0597 0.0903
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0376 0.0379
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0066 0.0597 0.1159
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0019 0.0079 0.0209
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0701 0.5104
Echinococcus granulosus GPCR family 2 0.0016 0.0044 0.0045
Schistosoma mansoni protein kinase 0.0066 0.0597 0.1263
Plasmodium falciparum calcium-dependent protein kinase 3 0.0066 0.0597 0.0597
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0019 0.0079 0.0168
Brugia malayi ORL1-like opioid receptor 0.0046 0.0376 0.0796
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0014 0.0027 0.0027
Onchocerca volvulus 0.0046 0.0376 0.6686
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0039 0.0302 0.0587
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0109 0.1082 0.2102
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0014 0.0027 0.0057
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0331 0.2409
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0019 0.0079 0.0209
Plasmodium falciparum proline--tRNA ligase 0.0075 0.0701 0.0701
Entamoeba histolytica hypothetical protein 0.0048 0.0399 0.1048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0154
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0582 0.1531
Onchocerca volvulus 0.0061 0.0549 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.0602
Schistosoma mansoni hypothetical protein 0.0046 0.0376 0.0796
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Loa Loa (eye worm) hypothetical protein 0.0061 0.0549 0.1066
Trichomonas vaginalis glucose transporter, putative 0.0135 0.1373 0.2905
Onchocerca volvulus Putative transporter 0.0061 0.0549 1
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0019 0.0079 0.008
Brugia malayi hypothetical protein 0.0046 0.0376 0.0796
Entamoeba histolytica recQ family helicase, putative 0.0019 0.008 0.0209
Echinococcus granulosus neuropeptide receptor 0.0046 0.0376 0.0379
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0046 0.0376 0.0379
Brugia malayi hypothetical protein 0.0046 0.0376 0.0796
Brugia malayi DNA polymerase family B containing protein 0.0019 0.0079 0.0168
Echinococcus granulosus nAChR subunit 0.0014 0.0027 0.0027
Onchocerca volvulus 0.0046 0.0376 0.6686
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3175 0.6719
Echinococcus granulosus dna polymerase kappa 0.0042 0.0331 0.0333
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0376 0.0796
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0331 0.2409
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0376 0.0796
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0104 0.0759
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Schistosoma mansoni opsin-like receptor 0.0046 0.0376 0.0796
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0046 0.0376 0.073
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0331 0.2409
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0014 0.0027 0.0057
Plasmodium falciparum hexose transporter 0.0436 0.4725 0.4725
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0014 0.0027 0.0052
Brugia malayi AKH receptor 0.0046 0.0376 0.0796
Echinococcus granulosus neuropeptide receptor A26 0.0046 0.0376 0.0379
Loa Loa (eye worm) hypothetical protein 0.0064 0.0582 0.1131
Schistosoma mansoni amine GPCR 0.0046 0.0376 0.0796
Brugia malayi hypothetical protein 0.0061 0.0549 0.1162
Loa Loa (eye worm) beta-lactamase 0.0037 0.0273 0.0531
Brugia malayi DNA polymerase alpha catalytic subunit 0.0019 0.0079 0.0168
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0019 0.008 0.008
Giardia lamblia DNA repair protein RAD52 0.0354 0.3802 1
Trypanosoma brucei glucose transporter, putative 0.0135 0.1373 1
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0549 0.1162
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0014 0.0027 0.0052
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0019 0.0079 0.0579
Toxoplasma gondii facilitative glucose transporter GT1 0.0436 0.4725 0.7147
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.0602
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0044 0.0094
Onchocerca volvulus 0.0061 0.0549 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0376 0.0379
Mycobacterium tuberculosis Conserved protein 0.0037 0.0273 0.1107
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0582 0.1232
Echinococcus granulosus neuropeptide s receptor 0.0046 0.0376 0.0379
Loa Loa (eye worm) ACC-1 protein 0.0014 0.0027 0.0052
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0066 0.0597 0.1159
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Mycobacterium tuberculosis Conserved protein 0.0037 0.0273 0.1107
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0019 0.0079 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0331 0.2409
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Onchocerca volvulus DNA polymerase homolog 0.0019 0.0079 0.101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0376 0.0796
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0014 0.0027 0.0057
Mycobacterium ulcerans hypothetical protein 0.0037 0.0273 0.1844
Brugia malayi Dopamine receptor protein 2 0.0046 0.0376 0.0796
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0273 0.1844
Trichomonas vaginalis DNA polymerase II, putative 0.0019 0.0079 0.0168
Schistosoma mansoni amine GPCR 0.0046 0.0376 0.0796
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0273 0.0276
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0273 0.0273
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0019 0.0079 0.008
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0014 0.0027 0.0052
Brugia malayi Serotonin receptor 0.0046 0.0376 0.0796
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0014 0.0027 0.0057
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0399 0.0844
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0161 0.0312
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Toxoplasma gondii DNA polymerase family B protein 0.0019 0.0079 0.012
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0903 0.992 1
Echinococcus granulosus flap endonuclease 1 0.0026 0.0161 0.0162
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.003 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0376 0.0796
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.3175 0.8351
Echinococcus granulosus somatostatin receptor 0.0046 0.0376 0.0379
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0046 0.0376 0.0796
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0079 0.0579
Schistosoma mansoni sugar transporter 0.0061 0.0549 0.1162
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0119 0.0801
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Loa Loa (eye worm) hypothetical protein 0.0061 0.0549 0.1066
Onchocerca volvulus 0.0046 0.0376 0.6686
Toxoplasma gondii ABC1 family protein 0.0037 0.0273 0.0413
Brugia malayi hypothetical protein 0.0046 0.0376 0.0796
Schistosoma mansoni biogenic amine receptor 0.0046 0.0376 0.0796
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Loa Loa (eye worm) hypothetical protein 0.0037 0.0273 0.0531
Mycobacterium leprae Probable lipase LipE 0.0037 0.0273 0.1844
Schistosoma mansoni nAChR subunit 0.0014 0.0027 0.0057
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0061 0.0549 0.3704
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0436 0.4725 0.4764
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.0602
Onchocerca volvulus 0.0046 0.0376 0.6686
Trypanosoma brucei glucose transporter 2A 0.0135 0.1373 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3175 0.6719
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0364 0.2654
Schistosoma mansoni DNA helicase recq5 0.0039 0.0302 0.0639
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0039 0.0302 0.0304
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0079 0.0579
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0376 0.0379
Echinococcus multilocularis transcription factor eb 0.011 0.1088 0.1097
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0061 0.0549 0.0553
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0154
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.0376 0.0379
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0044 0.0045
Trypanosoma cruzi sugar transporter, putative 0.0061 0.0549 0.3999
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0019 0.0079 0.0079
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0044 0.0094
Echinococcus granulosus neuropeptide FF receptor 2 0.0046 0.0376 0.0379
Brugia malayi hypothetical protein 0.0046 0.0376 0.0796
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3175 0.6719
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0014 0.0027 0.0027
Schistosoma mansoni protein kinase 0.0066 0.0597 0.1263
Onchocerca volvulus 0.0019 0.0079 0.101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0376 0.0796
Toxoplasma gondii sugar transporter ST2 0.0061 0.0549 0.083
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0066 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0019 0.0079 0.0168
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0376 0.0379
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0014 0.0027 0.0027
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0376 0.0379
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0019 0.0079 0.0579
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0075 0.0701 0.106
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0019 0.0079 0.0168
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Schistosoma mansoni opsin-like receptor 0.0046 0.0376 0.0796
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0046 0.0376 0.0796
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0046 0.0376 0.073
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0273 0.0578
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0331 0.2231
Echinococcus granulosus glycine receptor subunit alpha 1 0.0014 0.0027 0.0027
Brugia malayi Doublecortin family protein 0.0019 0.0079 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0218 0.1585
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0061 0.0549 0.3704
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0436 0.4725 0.4764
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0376 0.0379
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0161 0.0243
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Schistosoma mansoni hypothetical protein 0.0172 0.1784 0.3776
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0104 0.0422
Schistosoma mansoni neuropeptide receptor 0.0046 0.0376 0.0796
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0273 0.0578
Echinococcus multilocularis General substrate transporter 0.0375 0.4042 0.4075
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.003 0.003
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0061 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0035 0.0252 0.0489
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0046 0.0376 0.0796
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0014 0.0027 0.0027
Brugia malayi Serotonin receptor 0.0046 0.0376 0.0796
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0019 0.0079 0.0579
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0376 0.0379
Brugia malayi hypothetical protein 0.0061 0.0549 0.1162
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0376 0.0379
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Loa Loa (eye worm) hypothetical protein 0.015 0.1541 0.2993
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0364 0.0771
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.011 0.1088 0.2302
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0302 0.0457
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0044 0.0045
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.1373 0.2905
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.0399 0.0399
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.0399 0.2904
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0027 0.0057
Echinococcus multilocularis GPCR, family 2 0.0016 0.0044 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0549 0.1162
Brugia malayi hypothetical protein 0.0046 0.0376 0.0796
Plasmodium falciparum protein kinase 7 0.0606 0.6612 0.6612
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Entamoeba histolytica recQ family DNA helicase 0.002 0.0088 0.0232
Brugia malayi G protein-coupled receptor F59B2.13 0.0046 0.0376 0.0796
Echinococcus multilocularis G-protein coupled receptor, putative 0.0046 0.0376 0.0379
Echinococcus multilocularis solute carrier family 22 0.0061 0.0549 0.0553
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0273 0.1844
Loa Loa (eye worm) hypothetical protein 0.0064 0.0582 0.1131
Onchocerca volvulus 0.0046 0.0376 0.6686
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Echinococcus multilocularis nAChR subunit 0.0014 0.0027 0.0027
Echinococcus multilocularis glycine receptor subunit beta 0.0014 0.0027 0.0027
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0079 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0376 0.0379
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.0602
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0019 0.0079 0.101
Echinococcus granulosus General substrate transporter 0.0375 0.4042 0.4075
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0014 0.0027 0.0052
Echinococcus multilocularis RUN 0.0019 0.0079 0.008
Onchocerca volvulus 0.0061 0.0549 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.1145 0.1154
Schistosoma mansoni nAChR subunit 0.0014 0.0027 0.0057
Schistosoma mansoni amine GPCR 0.0399 0.4306 0.9112
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0331 0.2409
Mycobacterium ulcerans sugar transporter 0.0061 0.0549 0.3704
Brugia malayi Major Facilitator Superfamily protein 0.0061 0.0549 0.1162
Schistosoma mansoni hypothetical protein 0.0046 0.0376 0.0796
Trypanosoma brucei glucose transporter, putative 0.0135 0.1373 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0218 0.0423
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0376 0.0379
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0331 0.2409
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.1373 0.2905
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0066 0.0597 0.0903
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0318 0.2147
Schistosoma mansoni adenoreceptor 0.0046 0.0376 0.0796
Onchocerca volvulus 0.0037 0.0273 0.4722
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0273 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Schistosoma mansoni neuropeptide receptor 0.0046 0.0376 0.0796
Echinococcus multilocularis orexin receptor type 2 0.0046 0.0376 0.0379
Brugia malayi Dopamine receptor 0.0046 0.0376 0.0796
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0019 0.0079 0.008
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Loa Loa (eye worm) RecQ helicase 0.0066 0.0603 0.1172
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.1145 0.1154
Brugia malayi polk-prov protein 0.0032 0.0218 0.0461
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0066 0.0597 0.0602
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.043 0.0836
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0376 0.0379
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0046 0.0376 0.0796
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0046 0.0376 0.0379
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0376 0.073
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0273 0.1107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0066 0.0597 0.1263
Schistosoma mansoni sugar transporter 0.0061 0.0549 0.1162
Echinococcus granulosus hypothetical protein 0.0046 0.0376 0.0379
Mycobacterium ulcerans beta-lactamase 0.0037 0.0273 0.1844
Brugia malayi major facilitator superfamily protein 0.0061 0.0549 0.1162
Brugia malayi DNA polymerase delta catalytic subunit 0.0019 0.0079 0.0168
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0376 0.0796
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.1482 0.6001
Echinococcus granulosus biogenic amine 5HT receptor 0.0176 0.1821 0.1835
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.003 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0053 0.0389
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.043 0.091
Loa Loa (eye worm) hypothetical protein 0.0037 0.0273 0.0531
Schistosoma mansoni hypothetical protein 0.0019 0.0079 0.0168
Onchocerca volvulus 0.0061 0.0549 1
Loa Loa (eye worm) TYRA-2 protein 0.0046 0.0376 0.073
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0014 0.0027 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3175 0.6719
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0019 0.0079 0.101
Brugia malayi Major Facilitator Superfamily protein 0.0061 0.0549 0.1162
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0027 0.0057
Schistosoma mansoni nAChR subunit 0.0014 0.0027 0.0057
Onchocerca volvulus 0.0046 0.0376 0.6686
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Schistosoma mansoni hypothetical protein 0.0016 0.0044 0.0094
Echinococcus granulosus geminin 0.0172 0.1784 0.1799
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3175 0.6719
Schistosoma mansoni myosin xvIII 0.0046 0.0376 0.0796
Loa Loa (eye worm) hypothetical protein 0.0474 0.5148 1
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0019 0.0079 0.0168
Echinococcus granulosus tm gpcr rhodopsin 0.0903 0.992 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.247 1
Schistosoma mansoni hypothetical protein 0.0035 0.0252 0.0532
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0161 0.0422
Giardia lamblia Sgs1 DNA helicase, putative 0.0039 0.0302 0.0794
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0079 0.0579
Trypanosoma cruzi hexose transporter, putative 0.0074 0.0689 0.5023
Brugia malayi follicle stimulating hormone receptor 0.0046 0.0376 0.0796
Trypanosoma cruzi hexose transporter, putative 0.0135 0.1373 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0376 0.0379
Echinococcus granulosus glycine receptor subunit alpha 1 0.0014 0.0027 0.0027
Schistosoma mansoni alpha-1 adrenergic receptor 0.0046 0.0376 0.0796
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0376 0.0796
Mycobacterium ulcerans lipase LipD 0.0037 0.0273 0.1844
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0066 0.0597 0.0903
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0046 0.0376 0.0379
Echinococcus granulosus allatostatin A receptor 0.0046 0.0376 0.0379
Echinococcus granulosus 7tm_1 domain containing protein 0.0046 0.0376 0.0379
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0019 0.0079 0.0579
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0046 0.0376 0.0796
Plasmodium vivax calcium-dependent protein kinase, putative 0.0066 0.0597 0.0597
Schistosoma mansoni biogenic amine receptor 0.0046 0.0376 0.0796
Trypanosoma brucei glucose transporter, putative 0.0135 0.1373 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0014 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0061 0.0549 0.1066
Onchocerca volvulus 0.0061 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0582 0.0587
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0154
Trypanosoma brucei glucose transporter, putative 0.0135 0.1373 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0046 0.0376 0.0796
Brugia malayi sulfakinin receptor protein 0.0046 0.0376 0.0796
Loa Loa (eye worm) LGC-31 protein 0.0014 0.0027 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Brugia malayi GnHR receptor homolog 0.0046 0.0376 0.0796
Trypanosoma brucei glucose transporter, putative 0.0135 0.1373 1
Brugia malayi Melatonin receptor type 1A 0.0046 0.0376 0.0796
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0088 0.0186
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0582 0.3927
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0014 0.0027 0.0027
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Giardia lamblia Sugar-proton symporter 0.0061 0.0549 0.1444
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0161 0.1169
Onchocerca volvulus 0.0037 0.0273 0.4722
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0256 0.1864
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0079 0.0079
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0014 0.0027 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0376 0.0796
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0273 0.0578
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Schistosoma mansoni nAChR subunit 0.0014 0.0027 0.0057
Loa Loa (eye worm) hypothetical protein 0.0474 0.5148 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0273 0.0578
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.3175 0.8351
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0019 0.0079 0.008
Echinococcus granulosus g protein coupled receptor 0.0046 0.0376 0.0379
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0399 0.0844
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0331 0.2231
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0273 0.0531
Loa Loa (eye worm) hypothetical protein 0.0051 0.043 0.0836
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0046 0.0376 0.0379
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.003 0.0057
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0582 0.1232
Loa Loa (eye worm) hypothetical protein 0.0176 0.1821 0.3537
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.0602
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0014 0.0027 0.0057
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0046 0.0376 0.6686
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0019 0.0079 0.0079
Brugia malayi Sugar transporter family protein 0.0061 0.0549 0.1162
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0376 0.073
Onchocerca volvulus 0.0061 0.0549 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0161 0.1169
Loa Loa (eye worm) hypothetical protein 0.0061 0.0549 0.1066
Plasmodium falciparum mitogen-activated protein kinase 2 0.0347 0.3724 0.3724
Loa Loa (eye worm) major facilitator superfamily transporter 0.0061 0.0549 0.1066
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0376 0.0379
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Leishmania major protein kinase, putative 0.0066 0.0597 0.4348
Onchocerca volvulus 0.0046 0.0376 0.6686
Trypanosoma brucei glucose transporter, putative 0.0135 0.1373 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0436 0.4725 0.4764
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0376 0.073
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0331 0.2409
Leishmania major glucose transporter/membrane transporter D2, putative 0.0135 0.1373 1
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0019 0.0079 0.0168
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0376 0.0379
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0101 0.0986 0.2592
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0273 0.0578
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.016 0.031
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0364 0.2654
Schistosoma mansoni lipoxygenase 0.008 0.076 0.1608
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.003 0.0063
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0044 0.0045
Brugia malayi beta-lactamase family protein 0.0037 0.0273 0.0578
Schistosoma mansoni nAChR subunit 0.0014 0.0027 0.0057
Trypanosoma cruzi hexose transporter, putative 0.0135 0.1373 1
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0354 0.3802 1
Brugia malayi Cam kinase protein 1 0.0066 0.0597 0.1263
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0046 0.0376 0.0796
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0331 0.2409
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0046 0.0376 0.0379
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.0399 0.0402
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0014 0.0027 0.0027
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0376 0.0379
Trichomonas vaginalis DNA helicase recq1, putative 0.0066 0.0603 0.1277
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.0399 0.2904
Echinococcus granulosus g-protein coupled receptor 0.0046 0.0376 0.0379
Schistosoma mansoni rab6-interacting 0.0019 0.0079 0.0168
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0019 0.0079 0.008
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0066 0.0597 0.0597
Echinococcus granulosus alpha 1A adrenergic receptor 0.0046 0.0376 0.0379
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0027 0.0057
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3175 0.6719
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0331 0.07
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3175 0.6719
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0549 0.1162
Onchocerca volvulus 0.0046 0.0376 0.6686
Toxoplasma gondii sugar transporter ST3 0.0061 0.0549 0.083
Plasmodium vivax sugar transporter, putative 0.0061 0.0549 0.0549
Entamoeba histolytica protein kinase, putative 0.0066 0.0597 0.157
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0019 0.0079 0.0154
Trypanosoma brucei THT1 - hexose transporter, putative 0.0135 0.1373 1
Echinococcus granulosus sex peptide receptor 0.0046 0.0376 0.0379
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0014 0.0027 0.0052
Leishmania major glucose transporter, lmgt3 0.0135 0.1373 1
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Loa Loa (eye worm) hypothetical protein 0.0061 0.0549 0.1066
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0376 0.0379
Loa Loa (eye worm) hypothetical protein 0.0061 0.0549 0.1066
Onchocerca volvulus 0.0061 0.0549 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0273 0.1991
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0046 0.0376 0.0379
Brugia malayi Sugar transporter family protein 0.0436 0.4725 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0053 0.0389
Echinococcus multilocularis serotonin receptor 0.0176 0.1821 0.1835
Echinococcus granulosus glycine receptor subunit alpha 1 0.0014 0.0027 0.0027
Echinococcus multilocularis geminin 0.0172 0.1784 0.1799
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0046 0.0376 0.0796
Onchocerca volvulus 0.0061 0.0549 1
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0161 0.0422
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.0376 0.0796
Schistosoma mansoni rab6-interacting 0.0019 0.0079 0.0168
Echinococcus multilocularis solute carrier family 22 0.0061 0.0549 0.0553
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0252 0.0532
Leishmania major hypothetical protein, conserved 0.0061 0.0549 0.3999
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Schistosoma mansoni neuropeptide receptor 0.0046 0.0376 0.0796
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0273 0.0578
Echinococcus granulosus serotonin receptor 0.0046 0.0376 0.0379
Echinococcus granulosus g protein coupled receptor 0.0046 0.0376 0.0379
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0027 0.0057
Echinococcus granulosus glycine receptor subunit beta 0.0014 0.0027 0.0027
Brugia malayi hypothetical protein 0.0019 0.0079 0.0168
Echinococcus multilocularis serotonin receptor 0.0176 0.1821 0.1835
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0088 0.0642
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0061 0.0541 0.0541
Leishmania major hypothetical protein, conserved 0.0037 0.0273 0.1991
Brugia malayi hypothetical protein 0.0019 0.0079 0.0168
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0014 0.0027 0.0027
Schistosoma mansoni growth hormone secretagogue receptor 0.0046 0.0376 0.0796
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0302 0.0639
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.003 0.0063
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.0399 0.2904
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0376 0.0379
Loa Loa (eye worm) hypothetical protein 0.0037 0.0273 0.0531
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0039 0.0302 0.0304
Schistosoma mansoni DNA polymerase eta 0.0015 0.003 0.0063
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.0399 0.0399
Schistosoma mansoni loxhd1 0.0019 0.0079 0.0168
Loa Loa (eye worm) hypothetical protein 0.0061 0.0549 0.1066
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0019 0.0079 0.0168
Brugia malayi Major Facilitator Superfamily protein 0.0061 0.0549 0.1162
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0273 0.0578
Leishmania major DNA polymerase eta, putative 0.0015 0.003 0.0215
Echinococcus multilocularis neuropeptide receptor A26 0.0046 0.0376 0.0379
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0046 0.0376 0.0796
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0044 0.0086
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0376 0.0379
Schistosoma mansoni nAChR subunit 0.0014 0.0027 0.0057
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0086
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0701 0.5104
Schistosoma mansoni biogenic amine receptor 0.0046 0.0376 0.0796
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0376 0.0796
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0019 0.0079 0.101
Brugia malayi hypothetical protein 0.0046 0.0376 0.0796
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Brugia malayi Cation transporter family protein 0.0014 0.0027 0.0057
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.003 0.0215
Trichomonas vaginalis sugar transporter, putative 0.0135 0.1373 0.2905
Brugia malayi G-protein coupled receptor 0.0046 0.0376 0.0796
Schistosoma mansoni glucose transport protein 0.0436 0.4725 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0331 0.2409
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0171
Echinococcus multilocularis calcium dependent protein kinase 0.0062 0.0552 0.0556
Loa Loa (eye worm) hypothetical protein 0.0046 0.0376 0.073
Loa Loa (eye worm) hypothetical protein 0.0048 0.0399 0.0774
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0052
Onchocerca volvulus 0.0046 0.0376 0.6686
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0582 0.1232
Loa Loa (eye worm) hypothetical protein 0.0061 0.0549 0.1066
Trypanosoma cruzi hexose transporter, putative 0.0135 0.1373 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0061 0.0549 0.1066
Onchocerca volvulus 0.0061 0.0549 1
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0041 0.0327 0.0327
Brugia malayi G-protein coupled receptor 0.0046 0.0376 0.0796
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0027 0.0057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0376 0.0796
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0549 0.1162
Onchocerca volvulus 0.0061 0.0549 1
Plasmodium vivax proline--tRNA ligase, putative 0.0075 0.0701 0.0701

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 0.014 uM Antagonist activity against adenosine A1 receptor in human platelets ChEMBL. 1694546
Ki (functional) = 0.014 uM Antagonist activity against adenosine A1 receptor in human platelets ChEMBL. 1694546
Ki (functional) = 0.68 uM Antagonistic activity against adenosine A2 receptor in rat adipocytes ChEMBL. 1694546
Ki (functional) = 0.68 uM Antagonistic activity against adenosine A2 receptor in rat adipocytes ChEMBL. 1694546

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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