Detailed information for compound 838081

Basic information

Technical information
  • TDR Targets ID: 838081
  • Name: 2-[(3-methyl-2-oxo-1,3-benzoxazol-6-yl)sulfon ylamino]-N-(2-methylphenyl)-4-methylsulfanylb utanamide
  • MW: 449.544 | Formula: C20H23N3O5S2
  • H donors: 2 H acceptors: 4 LogP: 2.6 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCCC(C(=O)Nc1ccccc1C)NS(=O)(=O)c1ccc2c(c1)oc(=O)n2C
  • InChi: 1S/C20H23N3O5S2/c1-13-6-4-5-7-15(13)21-19(24)16(10-11-29-3)22-30(26,27)14-8-9-17-18(12-14)28-20(25)23(17)2/h4-9,12,16,22H,10-11H2,1-3H3,(H,21,24)
  • InChiKey: MBWGIXTTZQWCOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(3-methyl-2-oxo-1,3-benzoxazol-6-yl)sulfonylamino]-N-(2-methylphenyl)-4-methylsulfanyl-butanamide
  • 2-[(3-methyl-2-oxo-1,3-benzoxazol-6-yl)sulfonylamino]-N-(2-methylphenyl)-4-(methylthio)butanamide
  • 2-[(2-keto-3-methyl-1,3-benzoxazol-6-yl)sulfonylamino]-N-(2-methylphenyl)-4-(methylthio)butyramide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.0052 0.1108 0.1364
Brugia malayi intermediate filament protein 0.0028 0.0525 0.0918
Schistosoma mansoni neuropeptide receptor 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.002 0.0332 0.0409
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.01 0.2266 0.2266
Brugia malayi glucose-6-phosphate dehydrogenase 0.0104 0.2362 0.4128
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Brugia malayi AKH receptor 0.01 0.2266 0.396
Loa Loa (eye worm) melatonin receptor type 1A 0.01 0.2266 0.2788
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.01 0.2266 0.2266
Onchocerca volvulus 0.01 0.2266 0.3588
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0044 0.0172
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.01 0.2266 0.396
Echinococcus multilocularis lamin dm0 0.0028 0.0525 0.0525
Schistosoma mansoni neuropeptide F-like receptor 0.01 0.2266 0.2266
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0128 0.0128
Echinococcus granulosus L aminoadipate semialdehyde 0.0178 0.4152 0.4152
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.5721 0.5721
Schistosoma mansoni biogenic amine (dopamine) receptor 0.01 0.2266 0.2266
Echinococcus granulosus g protein coupled receptor 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.0013 0.0167 0.0206
Echinococcus granulosus rhodopsin orphan GPCR 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Echinococcus granulosus sentrin specific protease 8 0.0014 0.0203 0.0203
Mycobacterium ulcerans 6-phosphogluconolactonase 0.0009 0.008 0.0115
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.2266 0.2266
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0113 0.2585 1
Schistosoma mansoni opsin-like receptor 0.01 0.2266 0.2266
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.01 0.2266 0.2266
Echinococcus granulosus dro:myosuppressin receptor 0.01 0.2266 0.2266
Echinococcus multilocularis dro:myosuppressin receptor 0.01 0.2266 0.2266
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0485 0.0773
Schistosoma mansoni hypothetical protein 0.01 0.2266 0.2266
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0113 0.2585 0.4142
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Trypanosoma brucei hypothetical protein, conserved 0.005 0.1065 0.4501
Schistosoma mansoni pyruvate kinase 0.0072 0.158 0.158
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0003 0.0004
Brugia malayi Inositol-1 0.0041 0.0849 0.1484
Loa Loa (eye worm) Ulp1 protease 0.0014 0.0203 0.025
Schistosoma mansoni hypothetical protein 0.0421 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0494 0.4438
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Echinococcus granulosus tm gpcr rhodopsin 0.01 0.2266 0.2266
Plasmodium vivax pyruvate kinase 2, putative 0.0037 0.0741 0.2859
Loa Loa (eye worm) histone methyltransferase 0.001 0.0106 0.0131
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0052 0.1108 0.1108
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0104 0.2362 1
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0014 0.0203 0.0541
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0128 0.0224
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.2266 0.2266
Brugia malayi hypothetical protein 0.01 0.2266 0.396
Onchocerca volvulus 0.01 0.2266 0.3588
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0128 0.0128
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0494 0.1441
Mycobacterium tuberculosis Possible toxin MazF1 0.0137 0.3165 1
Mycobacterium leprae conserved hypothetical protein 0.005 0.1065 0.6646
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.01 0.2266 0.2788
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.005 0.1065 0.4112
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.2266 0.2266
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0018 0.0024
Loa Loa (eye worm) pyruvate kinase 0.0072 0.158 0.1944
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0525 0.0646
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0009 0.008 0.008
Trypanosoma brucei SUMO1/Ulp2, putative 0.0014 0.0203 0.0848
Brugia malayi hypothetical protein 0.01 0.2266 0.396
Brugia malayi hypothetical protein 0.01 0.2266 0.396
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0044 0.0044
Brugia malayi neuropeptide F receptor 0.01 0.2266 0.396
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0494 0.1441
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Onchocerca volvulus 0.0265 0.6236 1
Echinococcus multilocularis sex peptide receptor 0.01 0.2266 0.2266
Echinococcus multilocularis neuropeptide Y receptor 0.01 0.2266 0.2266
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0044 0.0054
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Mycobacterium tuberculosis Conserved protein 0.0137 0.3165 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0128 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0128 0.0158
Plasmodium vivax pyruvate kinase, putative 0.0072 0.158 0.6108
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0427 0.1641
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0306 0.0918
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0009 0.008 0.0693
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0014 0.0203 0.0775
Loa Loa (eye worm) hypothetical protein 0.0014 0.0203 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0427 0.1641
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0018 0.0024
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0014 0.0203 0.0203
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0332 0.0926
Brugia malayi hypothetical protein 0.01 0.2266 0.396
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0306 0.0918
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.01 0.2266 0.2266
Loa Loa (eye worm) TYRA-2 protein 0.01 0.2266 0.2788
Loa Loa (eye worm) hypothetical protein 0.0013 0.0167 0.0206
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.1053 0.184
Schistosoma mansoni survival motor neuron protein 0.005 0.1053 0.1053
Echinococcus multilocularis neuropeptide receptor A26 0.01 0.2266 0.2266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.2266 0.2266
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.005 0.1065 0.4316
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.0054
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.1235 0.4773
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0063 0.0063
Trypanosoma brucei pyruvate kinase 1, putative 0.0072 0.158 0.6686
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.01 0.2266 0.2788
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.01 0.2266 0.2266
Schistosoma mansoni peptide (allatostatin)-like receptor 0.01 0.2266 0.2266
Schistosoma mansoni neuropeptide f receptor 76f 0.01 0.2266 0.2266
Mycobacterium ulcerans hypothetical protein 0.0137 0.3165 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0674 0.2599
Loa Loa (eye worm) pyruvate kinase 0.0072 0.158 0.1944
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0104 0.2362 1
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0014 0.0203 0.0203
Brugia malayi RE15519p 0.01 0.2266 0.396
Schistosoma mansoni coup transcription factor 0.0011 0.0128 0.0128
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0494 0.1441
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0494 0.1512
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0044 0.0083
Entamoeba histolytica hypothetical protein 0.005 0.1065 0.9606
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.005 0.1065 0.3327
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0128 0.0128
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.01 0.2266 0.2266
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0849 0.3586
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0128 0.0136
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.002 0.0332 0.0409
Echinococcus multilocularis neuropeptide receptor 0.01 0.2266 0.2266
Onchocerca volvulus 0.01 0.2266 0.3588
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0128 0.0158
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0104 0.2362 0.2906
Plasmodium falciparum sentrin-specific protease 1 0.0052 0.1108 0.4281
Echinococcus multilocularis dnaJ subfamily B 0.0421 1 1
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0128 0.0128
Echinococcus granulosus 7TM GPCR rhodopsin 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.0026 0.0494 0.0607
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0674 0.0674
Echinococcus granulosus pyruvate kinase 0.0037 0.0741 0.0741
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0128 0.0128
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0106 0.0106
Brugia malayi putative neuropeptide receptor 0.01 0.2266 0.396
Echinococcus granulosus tachykinin peptides receptor 99D 0.01 0.2266 0.2266
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.1397 0.1397
Brugia malayi Pre-SET motif family protein 0.0233 0.5463 0.955
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.01 0.2266 0.2266
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0036 0.0726 0.225
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0332 0.1276
Echinococcus multilocularis g protein coupled receptor 0.01 0.2266 0.2266
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0063 0.0063
Brugia malayi hypothetical protein 0.01 0.2266 0.396
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0494 0.0863
Schistosoma mansoni opsin-like receptor 0.01 0.2266 0.2266
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0178 0.4152 0.7258
Onchocerca volvulus 0.01 0.2266 0.3588
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0104 0.2362 0.7427
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0427 0.0427
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0569 0.07
Echinococcus multilocularis L aminoadipate semialdehyde 0.0178 0.4152 0.4152
Echinococcus multilocularis translational activator gcn1 0.0006 0.0003 0.0003
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0044 0.0076
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0014 0.0203 0.0541
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.2266 0.2266
Echinococcus granulosus alpha 1A adrenergic receptor 0.01 0.2266 0.2266
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.1488 0.1488
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0052 0.1108 0.1108
Toxoplasma gondii pyruvate kinase PyK1 0.0072 0.158 0.6108
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0128 0.0128
Schistosoma mansoni growth hormone secretagogue receptor 0.01 0.2266 0.2266
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0044 0.0076
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0128 0.0128
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0044 0.0065
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0485 0.0773
Schistosoma mansoni ran 0.0024 0.0427 0.0427
Echinococcus multilocularis g-protein coupled receptor 0.01 0.2266 0.2266
Loa Loa (eye worm) pyruvate kinase 0.0015 0.022 0.027
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0044 0.0172
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0178 0.4152 0.4152
Echinococcus granulosus neuropeptide receptor 0.01 0.2266 0.2266
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0044 0.0366
Mycobacterium tuberculosis Toxin MazF2 0.0137 0.3165 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0128 0.0158
Echinococcus multilocularis neuropeptides capa receptor 0.01 0.2266 0.2266
Schistosoma mansoni opsin-like receptor 0.01 0.2266 0.2266
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.01 0.2266 0.2788
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0306 0.0918
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0427 0.0746
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0849 0.1357
Onchocerca volvulus 0.01 0.2266 0.3588
Mycobacterium tuberculosis Possible toxin MazF5 0.0137 0.3165 1
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.181
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0104 0.2362 0.2362
Entamoeba histolytica pyruvate kinase, putative 0.005 0.1059 0.955
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0008 0.0044 0.0054
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0494 0.1441
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0014 0.0203 0.0688
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0631 0.2663
Echinococcus granulosus allatostatin A receptor 0.01 0.2266 0.2266
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0494 0.1441
Echinococcus multilocularis pyruvate kinase 0.0072 0.158 0.158
Echinococcus multilocularis G protein coupled receptor 139 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0044 0.0076
Brugia malayi steroid hormone receptor 0.0011 0.0128 0.0224
Schistosoma mansoni lamin 0.0028 0.0525 0.0525
Echinococcus multilocularis pyruvate kinase 0.0037 0.0741 0.0741
Echinococcus multilocularis serotonin receptor 0.01 0.2266 0.2266
Brugia malayi gonadotropin-releasing hormone receptor 2 0.01 0.2266 0.396
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.005 0.1065 0.3271
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.181
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0343 0.8126 1
Brugia malayi larval opioid receptor 0.01 0.2266 0.396
Schistosoma mansoni hypothetical protein 0.0343 0.8126 0.8126
Echinococcus granulosus cpg binding protein 0.0031 0.0609 0.0609
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0494 0.2079
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0106 0.0106
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0113 0.2585 1
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0033 0.0663 0.267
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0044 0.0054
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0494 0.4438
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.0009 0.008 0.0324
Schistosoma mansoni pyruvate kinase 0.0037 0.0741 0.0741
Schistosoma mansoni biogenic amine (dopamine) receptor 0.01 0.2266 0.2266
Brugia malayi Pyruvate kinase, muscle isozyme 0.0072 0.158 0.2762
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.2266 0.2266
Echinococcus granulosus sentrin specific protease 1 0.0052 0.1108 0.1108
Onchocerca volvulus 0.0034 0.0674 0.1018
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0128 0.0224
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0128 0.0128
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.005 0.1065 0.4112
Schistosoma mansoni hypothetical protein 0.01 0.2266 0.2266
Echinococcus multilocularis sentrin specific protease 1 0.0052 0.1108 0.1108
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0494 0.1441
Schistosoma mansoni hypothetical protein 0.01 0.2266 0.2266
Echinococcus multilocularis g protein coupled receptor 0.01 0.2266 0.2266
Brugia malayi CXXC zinc finger family protein 0.003 0.0569 0.0994
Echinococcus granulosus g-protein coupled receptor 0.01 0.2266 0.2266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.0168 0.3916 0.4819
Schistosoma mansoni alpha-1 adrenergic receptor 0.01 0.2266 0.2266
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0009 0.008 0.0155
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0179 0.0179
Echinococcus granulosus tm gpcr rhodopsin 0.01 0.2266 0.2266
Mycobacterium tuberculosis Toxin MazF6 0.0137 0.3165 1
Echinococcus multilocularis pyruvate kinase 0.0056 0.1217 0.1217
Brugia malayi nuclear hormone receptor 0.0011 0.0128 0.0224
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.1488 0.4672
Loa Loa (eye worm) hypothetical protein 0.002 0.0332 0.0409
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0631 0.0631
Brugia malayi RNA, U transporter 1 0.0091 0.2059 0.36
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0014 0.0203 0.0321
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.005 0.1065 0.3271
Brugia malayi ecdysteroid receptor 0.0011 0.0128 0.0224
Schistosoma mansoni importin beta-1 0.0032 0.0631 0.0631
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0849 0.1357
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0018 0.0024
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0494 0.2079
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0022 0.0378 0.0661
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0044 0.0083
Loa Loa (eye worm) hypothetical protein 0.0032 0.0631 0.0777
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Echinococcus granulosus snurportin 1 0.0343 0.8126 0.8126
Onchocerca volvulus 0.01 0.2266 0.3588
Echinococcus multilocularis sentrin specific protease 8 0.0014 0.0203 0.0203
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0018 0.0024
Brugia malayi kap beta 3 protein 0.0006 0.0003 0.0005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0063 0.0063
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0332 0.1108
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0128 0.0128
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.5463 0.6723
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0427 0.0525
Schistosoma mansoni cpg binding protein 0.0031 0.0609 0.0609
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.01 0.2266 0.2266
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0306 0.0918
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.181
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.2266 0.2266
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.158 0.2481
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0332 0.1001
Onchocerca volvulus 0.005 0.1053 0.163
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0427 0.1641
Echinococcus granulosus peptide allatostatin:somatostatin 0.01 0.2266 0.2266
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0052 0.1108 0.4281
Echinococcus multilocularis pyruvate kinase 0.0037 0.0741 0.0741
Leishmania major 6-phosphogluconolactonase 0.0009 0.008 0.0324
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.1488 0.5751
Schistosoma mansoni biogenic amine (dopamine) receptor 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.0243 0.5721 0.704
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1488 0.1488
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.01 0.2266 0.396
Echinococcus granulosus 7tm_1 domain containing protein 0.01 0.2266 0.2266
Onchocerca volvulus 0.0168 0.3916 0.6254
Echinococcus granulosus neuropeptide s receptor 0.01 0.2266 0.2266
Echinococcus multilocularis neuropeptide Y receptor 0.01 0.2266 0.2266
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.01 0.2266 0.2266
Echinococcus granulosus neuropeptide Y receptor 0.01 0.2266 0.2266
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0052 0.1108 1
Schistosoma mansoni pyruvate kinase 0.0072 0.158 0.158
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0104 0.2362 1
Echinococcus granulosus sex peptide receptor 0.01 0.2266 0.2266
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0009 0.008 0.0123
Schistosoma mansoni biogenic amine (5HT) receptor 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0629 0.0629
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.2266 0.2266
Onchocerca volvulus 0.01 0.2266 0.3588
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.01 0.2266 0.2266
Echinococcus multilocularis sentrin specific protease 7 0.0014 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Schistosoma mansoni amine GPCR 0.01 0.2266 0.2266
Echinococcus granulosus biogenic amine 5HT receptor 0.01 0.2266 0.2266
Brugia malayi hypothetical protein 0.01 0.2266 0.396
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Brugia malayi Tachykinin-like peptides receptor 99D 0.01 0.2266 0.396
Giardia lamblia Pyruvate kinase 0.0072 0.158 0.5989
Schistosoma mansoni myosin xvIII 0.01 0.2266 0.2266
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0044 0.0157
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0128 0.0128
Echinococcus multilocularis transportin 1 0.0006 0.0003 0.0003
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.158 0.2481
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0044 0.0083
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0215 0.0264
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0128 0.0136
Schistosoma mansoni amine GPCR 0.01 0.2266 0.2266
Brugia malayi hypothetical protein 0.01 0.2266 0.396
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0128 0.0128
Echinococcus granulosus tm gpcr rhodopsin 0.01 0.2266 0.2266
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0003 0.0004
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.01 0.2266 0.2788
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.002 0.0332 0.0409
Echinococcus granulosus sentrin specific protease 7 0.0014 0.0203 0.0203
Echinococcus granulosus g protein coupled receptor 0.01 0.2266 0.2266
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0018 0.0024
Echinococcus granulosus translational activator gcn1 0.0006 0.0003 0.0003
Toxoplasma gondii pyruvate kinase PyKII 0.0037 0.0741 0.2859
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0128 0.0224
Onchocerca volvulus 0.0026 0.0494 0.0727
Echinococcus multilocularis g protein coupled receptor 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.0026 0.0494 0.0607
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0525 0.0918
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.0027 0.0513 0.0631
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Onchocerca volvulus 0.01 0.2266 0.3588
Brugia malayi sulfakinin receptor protein 0.01 0.2266 0.396
Echinococcus multilocularis serotonin receptor 0.01 0.2266 0.2266
Mycobacterium leprae Probable 6-phosphogluconolactonase DevB (6PGL) 0.0009 0.008 0.0235
Plasmodium falciparum pyruvate kinase 0.0072 0.158 0.6108
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0128 0.0224
Onchocerca volvulus 0.01 0.2266 0.3588
Schistosoma mansoni biogenic amine receptor 0.01 0.2266 0.2266
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0052 0.1108 0.1937
Brugia malayi hypothetical protein 0.0168 0.3916 0.6846
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0494 0.0863
Echinococcus granulosus orexin receptor type 2 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Plasmodium falciparum importin beta, putative 0.0032 0.0631 0.2433
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0494 0.1441
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0631 0.2663
Echinococcus granulosus somatostatin receptor 0.01 0.2266 0.2266
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.01 0.2266 0.2266
Loa Loa (eye worm) G-protein coupled receptor 0.01 0.2266 0.2788
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.0355
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.005 0.1053 0.1053
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0849 0.7653
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.01 0.2266 0.2266
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0128 0.0224
Trypanosoma cruzi pyruvate kinase 2, putative 0.0072 0.158 0.6628
Trypanosoma brucei 6-phosphogluconolactonase 0.0009 0.008 0.0324
Entamoeba histolytica Ran family GTPase 0.0024 0.0427 0.3833
Onchocerca volvulus 0.0178 0.4152 0.6635
Echinococcus multilocularis lamin 0.0028 0.0525 0.0525
Treponema pallidum 4'-phosphopantetheinyl transferase 0.005 0.1065 0.4316
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.005 0.1065 0.4112
Echinococcus granulosus pyruvate kinase 0.0037 0.0741 0.0741
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0104 0.2362 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0128 0.0136
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Echinococcus granulosus thyrotropin releasing hormone receptor 0.01 0.2266 0.2266
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0849 0.3474
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0018 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0128 0.0128
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0849 0.3586
Brugia malayi G protein-coupled receptor F59B2.13 0.01 0.2266 0.396
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0203 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0128 0.0224
Schistosoma mansoni amine GPCR 0.01 0.2266 0.2266
Schistosoma mansoni ran 0.0024 0.0427 0.0427
Echinococcus granulosus G protein coupled receptor 139 0.01 0.2266 0.2266
Onchocerca volvulus 0.01 0.2266 0.3588
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.2266 0.2266
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0044 0.0076
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0494 0.4438
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Onchocerca volvulus 0.01 0.2266 0.3588
Brugia malayi nuclear receptor NHR-88 0.0011 0.0128 0.0224
Echinococcus granulosus neuropeptide receptor 0.01 0.2266 0.2266
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0128 0.0224
Leishmania major GTP-binding protein, putative 0.0024 0.0427 0.1796
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1488 0.1488
Leishmania major importin beta-1 subunit, putative 0.0026 0.0485 0.2042
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0128 0.0128
Echinococcus granulosus neuropeptides capa receptor 0.01 0.2266 0.2266
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0072 0.158 0.4964
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Brugia malayi putative neuropeptide receptor NPR1 0.01 0.2266 0.396
Schistosoma mansoni amine GPCR 0.01 0.2266 0.2266
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0104 0.2362 0.2362
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Mycobacterium ulcerans pyruvate kinase 0.0072 0.158 0.4922
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Schistosoma mansoni biogenic amine (5HT) receptor 0.01 0.2266 0.2266
Echinococcus multilocularis cpg binding protein 0.0031 0.0609 0.0609
Brugia malayi 6-phosphogluconolactonase family protein 0.0009 0.008 0.0139
Brugia malayi hypothetical protein 0.01 0.2266 0.396
Brugia malayi Serotonin receptor 0.01 0.2266 0.396
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0427 0.1385
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0427 0.1653
Plasmodium vivax sentrin-specific protease 2, putative 0.0014 0.0203 0.0775
Echinococcus granulosus intermediate filament protein 0.0028 0.0525 0.0525
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0485 0.1903
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Schistosoma mansoni biogenic amine receptor 0.01 0.2266 0.2266
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0674 0.0674
Brugia malayi pyruvate kinase 0.0015 0.022 0.0384
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0745 0.2311
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0128 0.0224
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.01 0.2266 0.2266
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1488 0.4627
Echinococcus multilocularis tachykinin peptides receptor 99D 0.01 0.2266 0.2266
Trichomonas vaginalis pyruvate kinase, putative 0.0072 0.158 0.253
Brugia malayi Dopamine receptor 0.01 0.2266 0.396
Echinococcus multilocularis somatostatin receptor 0.01 0.2266 0.2266
Brugia malayi ORL1-like opioid receptor 0.01 0.2266 0.396
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0104 0.2362 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.01 0.2266 0.2266
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0113 0.2585 0.4142
Schistosoma mansoni histamine h1 receptor 0.01 0.2266 0.2266
Echinococcus multilocularis importin 5 0.0006 0.0003 0.0003
Brugia malayi Serotonin/octopamine receptor family protein 7 0.01 0.2266 0.396
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0128 0.0224
Mycobacterium tuberculosis Toxin MazF3 0.0137 0.3165 1
Brugia malayi G protein-coupled receptor 0.01 0.2266 0.396
Echinococcus multilocularis snurportin 1 0.0343 0.8126 0.8126
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0128 0.0224
Trichomonas vaginalis ran, putative 0.0024 0.0427 0.068
Schistosoma mansoni importin-beta 2 0.0006 0.0003 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0494 0.2928
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.5721 0.5721
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0674 0.0674
Trichomonas vaginalis pyruvate kinase, putative 0.0072 0.158 0.253
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.01 0.2266 0.2266
Echinococcus granulosus neuropeptide Y receptor 0.01 0.2266 0.2266
Schistosoma mansoni neuropeptide receptor 0.01 0.2266 0.2266
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0044 0.0083
Echinococcus granulosus lamin dm0 0.0028 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.005 0.1059 0.1303
Echinococcus granulosus lamin 0.0028 0.0525 0.0525
Echinococcus granulosus pyruvate kinase 0.0072 0.158 0.158
Echinococcus multilocularis musashi 0.0028 0.0525 0.0525
Schistosoma mansoni lamin 0.0028 0.0525 0.0525
Giardia lamblia Pyruvate kinase 0.0037 0.0741 0.2641
Echinococcus granulosus rhodopsin orphan GPCR 0.01 0.2266 0.2266
Mycobacterium ulcerans hypothetical protein 0.0026 0.0494 0.1441
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.2266 0.2266
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0128 0.0128
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0063 0.0063
Echinococcus multilocularis 6 phosphogluconolactonase 0.0009 0.008 0.008
Echinococcus granulosus neuropeptide FF receptor 2 0.01 0.2266 0.2266
Echinococcus granulosus hypothetical protein 0.01 0.2266 0.2266
Loa Loa (eye worm) Ulp1 protease 0.0014 0.0203 0.025
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Echinococcus multilocularis neuropeptide s receptor 0.01 0.2266 0.2266
Echinococcus multilocularis allatostatin A receptor 0.01 0.2266 0.2266
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0745 0.4564
Trichomonas vaginalis set domain proteins, putative 0.0265 0.6236 1
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0068 0.1493 0.4643
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0009 0.008 0.0155
Leishmania major pyruvate kinase 0.0072 0.158 0.6686
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0014 0.0203 0.0775
Echinococcus granulosus serotonin receptor 0.01 0.2266 0.2266
Echinococcus multilocularis neuropeptide receptor 0.01 0.2266 0.2266
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0044 0.0083
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0128 0.0224
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0128 0.0128
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0215 0.0376
Loa Loa (eye worm) pyruvate kinase-PB 0.005 0.1059 0.1303
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Echinococcus granulosus rhodopsin orphan GPCR 0.01 0.2266 0.2266
Schistosoma mansoni neuropeptide receptor 0.01 0.2266 0.2266
Echinococcus granulosus 6 phosphogluconolactonase 0.0009 0.008 0.008
Schistosoma mansoni hypothetical protein 0.01 0.2266 0.2266
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0128 0.0128
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0044 0.0083
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.01 0.2266 0.2266
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0044 0.0076
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0494 0.1512
Chlamydia trachomatis pyruvate kinase 0.0072 0.158 0.6574
Loa Loa (eye worm) neuropeptide F receptor 0.01 0.2266 0.2788
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Plasmodium vivax SET domain protein, putative 0.0034 0.0674 0.2599
Loa Loa (eye worm) hypothetical protein 0.002 0.0332 0.0409
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0044 0.0083
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.0355
Schistosoma mansoni 6-phosphogluconolactonase 0.0009 0.008 0.008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0494 0.2928
Schistosoma mansoni 6-phosphogluconolactonase 0.0009 0.008 0.008
Echinococcus granulosus rhodopsin orphan GPCR 0.01 0.2266 0.2266
Loa Loa (eye worm) oxidoreductase 0.0008 0.0044 0.0054
Schistosoma mansoni amine GPCR 0.01 0.2266 0.2266
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0128 0.0128
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0044 0.0172
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.01 0.2266 0.2266
Onchocerca volvulus 0.01 0.2266 0.3588
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0494 0.2079
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0044 0.0157
Brugia malayi G-protein coupled receptor 0.01 0.2266 0.396
Onchocerca volvulus 0.01 0.2266 0.3588
Mycobacterium tuberculosis Toxin MazF9 0.0137 0.3165 1
Onchocerca volvulus 0.003 0.0569 0.0848
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Schistosoma mansoni cpg binding protein 0.0031 0.0609 0.0609
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.181
Loa Loa (eye worm) hypothetical protein 0.0028 0.0525 0.0646
Leishmania major pyruvate kinase 0.0072 0.158 0.6686
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0104 0.2362 0.2362
Brugia malayi pyruvate kinase, muscle isozyme 0.0015 0.022 0.0384
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.2266 0.2266
Loa Loa (eye worm) neuropeptide F receptor 0.01 0.2266 0.2788
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0525 0.0646
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0128 0.0128
Schistosoma mansoni inositol monophosphatase 0.0041 0.0849 0.0849
Brugia malayi follicle stimulating hormone receptor 0.01 0.2266 0.396
Plasmodium vivax sentrin-specific protease 1, putative 0.0052 0.1108 0.4281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0128 0.0158
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.01 0.2266 0.2266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0128 0.0158
Brugia malayi G-protein coupled receptor 0.01 0.2266 0.396
Echinococcus multilocularis G-protein coupled receptor, putative 0.01 0.2266 0.2266
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0044 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0128 0.0224
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0631 0.2433
Plasmodium falciparum pyruvate kinase 2 0.0037 0.0741 0.2859
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Echinococcus granulosus importin subunit beta 1 0.0032 0.0631 0.0631
Brugia malayi hypothetical protein 0.0243 0.5721 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0128 0.0224
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0044 0.0076
Loa Loa (eye worm) pyruvate kinase 0.0072 0.158 0.1944
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.1488 0.1488
Echinococcus granulosus rhodopsin orphan GPCR 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.0014 0.0203 0.025
Brugia malayi Dopamine receptor protein 1 0.01 0.2266 0.396
Leishmania major phosphopantetheinyl transferase-like protein 0.005 0.1065 0.4501
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1488 0.4627
Brugia malayi Melatonin receptor type 1A 0.01 0.2266 0.396
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0044 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0674 0.0674
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0427 0.1796
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.181
Schistosoma mansoni cpg binding protein 0.003 0.0569 0.0569
Onchocerca volvulus Neuropeptide F receptor homolog 0.01 0.2266 0.3588
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0128 0.0128
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0018 0.0024
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.01 0.2266 0.3588
Leishmania major glucosamine-6-phosphate isomerase, putative 0.0009 0.008 0.0324
Loa Loa (eye worm) hypothetical protein 0.0178 0.4152 0.5109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0128 0.0128
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0332 0.1276
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.0355
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.01 0.2266 0.2266
Onchocerca volvulus 0.0011 0.0128 0.0136
Brugia malayi hypothetical protein 0.01 0.2266 0.396
Onchocerca volvulus 0.0028 0.0525 0.0778
Echinococcus multilocularis neuropeptides capa receptor 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0128 0.0224
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Trichomonas vaginalis helicase, putative 0.0007 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Onchocerca volvulus 0.01 0.2266 0.3588
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0068 0.1493 0.577
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0128 0.0158
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.005 0.1065 0.4112
Echinococcus multilocularis pyruvate kinase 0.0072 0.158 0.158
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.1488 0.6295
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0113 0.2585 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0044 0.0083
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0128 0.0128
Brugia malayi hypothetical protein 0.01 0.2266 0.396
Trichomonas vaginalis Sentrin-specific protease, putative 0.0014 0.0203 0.0321
Mycobacterium tuberculosis Possible toxin MazF4 0.0137 0.3165 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0674 0.0674
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0494 0.0863
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0044 0.0172
Loa Loa (eye worm) follicle stimulating hormone receptor 0.01 0.2266 0.2788
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0044 0.0083
Echinococcus granulosus transportin 1 0.0006 0.0003 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.01 0.2266 0.2266
Echinococcus granulosus neuropeptide receptor A26 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.0013 0.0179 0.0221
Brugia malayi Pyruvate kinase, M2 isozyme 0.0072 0.158 0.2762
Giardia lamblia Sentrin specific protease, putative 0.0014 0.0203 0.0493
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0849 0.1357
Schistosoma mansoni biogenic amine receptor 0.01 0.2266 0.2266
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.01 0.2266 0.396
Echinococcus granulosus fmrfamide receptor 0.01 0.2266 0.2266
Trypanosoma brucei pyruvate kinase 1 0.0072 0.158 0.6686
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Onchocerca volvulus Pyruvate kinase homolog 0.0072 0.158 0.2481
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.01 0.2266 0.2266
Brugia malayi Pre-SET motif family protein 0.0034 0.0674 0.1178
Brugia malayi neuropeptide F receptor 0.01 0.2266 0.396
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0179 0.0179
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.01 0.2266 0.2266
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0128 0.0128
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0849 0.258
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0128 0.0128
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0018 0.0024
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0849 0.0849
Trypanosoma cruzi pyruvate kinase 2, putative 0.0072 0.158 0.6628
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0849 0.3474
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0128 0.0128
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0009 0.008 0.0155
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0052 0.1108 0.1773
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0044 0.0065
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0674 0.0674
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0128 0.0128
Echinococcus multilocularis fmrfamide receptor 0.01 0.2266 0.2266
Schistosoma mansoni neuropeptide receptor 0.01 0.2266 0.2266
Echinococcus granulosus biogenic amine 5HT receptor 0.01 0.2266 0.2266
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0044 0.0157
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0104 0.0181
Echinococcus granulosus pyruvate kinase 0.0037 0.0741 0.0741
Echinococcus granulosus pyruvate kinase 0.0072 0.158 0.158
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0034 0.0674 0.083
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0128 0.0224
Brugia malayi Importin beta-1 subunit 0.0032 0.0631 0.1103
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Onchocerca volvulus 0.0014 0.0203 0.0258
Brugia malayi Serotonin receptor 0.01 0.2266 0.396
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0128 0.0128
Mycobacterium tuberculosis Possible toxin MazF7 0.0137 0.3165 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0044 0.0157
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0009 0.008 0.0155
Echinococcus multilocularis fmrfamide receptor 0.01 0.2266 0.2266
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0044 0.0083
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0128 0.0158
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0485 0.0773
Echinococcus multilocularis neuropeptide FF receptor 2 0.01 0.2266 0.2266
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0113 0.2585 1
Echinococcus granulosus neuropeptides capa receptor 0.01 0.2266 0.2266
Loa Loa (eye worm) inositol-1 0.0041 0.0849 0.1045
Loa Loa (eye worm) G-protein coupled receptor 0.01 0.2266 0.2788
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0113 0.2585 0.4142
Trypanosoma cruzi hypothetical protein 0.0014 0.0203 0.0688
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.01 0.2266 0.2266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.2266 0.2266
Brugia malayi GnHR receptor homolog 0.01 0.2266 0.396
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0044 0.0083
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0849 0.3276
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0849 0.0849
Entamoeba histolytica hypothetical protein 0.0026 0.0485 0.4358
Echinococcus multilocularis alpha 1A adrenergic receptor 0.01 0.2266 0.2266
Schistosoma mansoni adenoreceptor 0.01 0.2266 0.2266
Brugia malayi Dopamine receptor protein 2 0.01 0.2266 0.396
Schistosoma mansoni neuropeptide F-like receptor 0.01 0.2266 0.2266
Echinococcus multilocularis rhodopsin orphan GPCR 0.01 0.2266 0.2266
Onchocerca volvulus 0.01 0.2266 0.3588
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0014 0.0203 0.0848
Schistosoma mansoni intermediate filament proteins 0.0028 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0072 0.158 0.1944
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Echinococcus granulosus importin 5 0.0006 0.0003 0.0003
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0427 0.1653
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.005 0.1065 1
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0014 0.0203 0.0688
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0009 0.008 0.0098
Schistosoma mansoni rhodopsin-like orphan GPCR 0.01 0.2266 0.2266
Onchocerca volvulus 0.01 0.2266 0.3588
Echinococcus multilocularis pyruvate kinase 0.0037 0.0741 0.0741
Echinococcus multilocularis orexin receptor type 2 0.01 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.01 0.2266 0.2788
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0034 0.0687 0.2774
Echinococcus granulosus rhodopsin orphan GPCR 0.01 0.2266 0.2266
Mycobacterium leprae Probable pyruvate kinase PykA 0.0072 0.158 1
Echinococcus granulosus g protein coupled receptor 0.01 0.2266 0.2266
Onchocerca volvulus 0.0028 0.0525 0.0778
Plasmodium vivax importin-beta 2, putative 0.0032 0.0631 0.2433
Onchocerca volvulus 0.01 0.2266 0.3588
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1488 0.4627
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0128 0.0224
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0026 0.0494 0.0607
Schistosoma mansoni inositol monophosphatase 0.0041 0.0849 0.0849

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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