Detailed information for compound 84401

Basic information

Technical information
  • TDR Targets ID: 84401
  • Name: 6,8-dibromo-3-[(2R,3R)-3-(2,4-difluorophenyl) -3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]q uinazolin-4-one
  • MW: 555.17 | Formula: C20H15Br2F2N5O2
  • H donors: 1 H acceptors: 4 LogP: 3.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: Fc1ccc(c(c1)F)[C@]([C@H](n1cnc2c(c1=O)cc(cc2Br)Br)C)(Cn1ncnc1)O
  • InChi: 1S/C20H15Br2F2N5O2/c1-11(29-10-26-18-14(19(29)30)4-12(21)5-16(18)22)20(31,7-28-9-25-8-27-28)15-3-2-13(23)6-17(15)24/h2-6,8-11,31H,7H2,1H3/t11-,20-/m1/s1
  • InChiKey: GAUNGVMJFMECAI-BIBXISHDSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6,8-dibromo-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1,2,4-triazol-1-yl)propyl]quinazolin-4-one
  • 6,8-dibromo-3-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1,2,4-triazol-1-yl)propyl]-4-quinazolinone
  • (1R,2R)-6,8-Dibromo-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one
  • AIDS-097860
  • AIDS097860

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Schistosoma mansoni cpg binding protein 0.0031 0.0143 0.0143
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0113 0.073 1
Onchocerca volvulus 0.0046 0.0247 0.3937
Trichomonas vaginalis glutaminase, putative 0.0281 0.1926 0.8628
Plasmodium falciparum mitogen-activated protein kinase 2 0.0525 0.3661 0.3762
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0324 0.2232 0.2232
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0046 0.0247 0.1281
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0187 0.08
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.1106
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0167 0.4483
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0063 0.0374 0.1676
Echinococcus granulosus dnaJ subfamily B 0.0417 0.2897 0.2897
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Echinococcus granulosus glycyl tRNA synthetase 0.0018 0.0052 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0268 0.3675
Schistosoma mansoni sugar transporter 0.0046 0.0247 0.0247
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0284 0.0284
Trypanosoma brucei unspecified product 0.0014 0.002 0.0267
Giardia lamblia Hexose transporter 0.0046 0.0247 0.296
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0034 0.0167 0.0866
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0302 0.2075 0.2075
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0046 0.0247 0.0247
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0021 0.0191
Brugia malayi mbt repeat family protein 0.0049 0.0272 0.1181
Plasmodium vivax lysine--tRNA ligase, putative 0.0072 0.0438 0.045
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0186 0.0186
Echinococcus multilocularis dna polymerase kappa 0.002 0.0063 0.0063
Schistosoma mansoni sugar transporter 0.0046 0.0247 0.0247
Schistosoma mansoni protein kinase 0.01 0.0636 0.0636
Echinococcus granulosus tumor protein p63 0.0347 0.2399 0.2399
Leishmania major DNA polymerase eta, putative 0.0046 0.025 0.3428
Plasmodium vivax sugar transporter, putative 0.0046 0.0247 0.0254
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0268 0.1393
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.01 0.0636 0.0986
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0059 0.0805
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0018 0.0052 0.2103
Plasmodium falciparum proline--tRNA ligase 0.0113 0.073 0.075
Trypanosoma cruzi sugar transporter, putative 0.0046 0.0247 0.3381
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0247 0.1106
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0065
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0018 0.0052 0.027
Echinococcus multilocularis tumor protein p63 0.0347 0.2399 0.2399
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0113 0.073 1
Trypanosoma brucei glucose transporter, putative 0.01 0.0638 0.8747
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0038 0.0038
Onchocerca volvulus 0.0051 0.0284 0.4562
Treponema pallidum threonyl-tRNA synthetase 0.0018 0.0052 0.3113
Leishmania major glucose transporter/membrane transporter D2, putative 0.01 0.0638 0.8747
Brugia malayi major facilitator superfamily protein 0.0046 0.0247 0.1069
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0021 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0247 0.1106
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0087 0.0539 0.2415
Trypanosoma brucei glucosidase, putative 0.0037 0.0187 0.2562
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0268 0.7384
Echinococcus multilocularis glycyl tRNA synthetase 0.0018 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.01 0.0636 0.285
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0324 0.2232 0.2232
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0024 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0324 0.2232 1
Schistosoma mansoni glucose transporter 0.0046 0.0247 0.0247
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0037 0.0504
Brugia malayi major facilitator superfamily protein 0.0046 0.0247 0.1069
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Leishmania major glucose transporter, lmgt2 0.01 0.0638 0.8747
Loa Loa (eye worm) patched family protein 0.0012 0.0009 0.0041
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0018 0.0052 0.0382
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.01 0.0636 0.285
Schistosoma mansoni hypothetical protein 0.0083 0.0517 0.0517
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0063 0.0869
Echinococcus multilocularis solute carrier family 22 0.0046 0.0247 0.0247
Trichomonas vaginalis myo-inositol transporter, putative 0.0046 0.0247 0.1106
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0353 0.0353
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0187 0.0838
Loa Loa (eye worm) hypothetical protein 0.0106 0.0678 0.3037
Leishmania major hypothetical protein, conserved 0.0046 0.0247 0.3381
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0052 0.0711
Echinococcus granulosus solute carrier family 22 0.0046 0.0247 0.0247
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0038 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0037 0.0037
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0024 0.0403
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0059 0.0059
Schistosoma mansoni protein kinase 0.01 0.0636 0.0636
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0059 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0636 0.0636
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0111 0.071 0.9732
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0403
Onchocerca volvulus Putative transporter 0.0046 0.0247 0.3937
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0268 0.1165
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.025 0.3428
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0318 0.0492
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0268 0.1165
Toxoplasma gondii glycyl-tRNA synthetase 0.0018 0.0052 0.008
Echinococcus granulosus dna polymerase kappa 0.002 0.0063 0.0063
Brugia malayi jmjC domain containing protein 0.0016 0.0037 0.0125
Brugia malayi Major Facilitator Superfamily protein 0.0046 0.0247 0.1069
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0187 0.2562
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0063 0.0244
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0024 0.0065
Onchocerca volvulus 0.0046 0.0247 0.3937
Trypanosoma brucei glucose transporter, putative 0.01 0.0638 0.8747
Plasmodium falciparum lysine--tRNA ligase 0.0072 0.0438 0.045
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0018 0.0052 0.0233
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0072 0.0438 0.196
Schistosoma mansoni alpha-glucosidase 0.0144 0.095 0.095
Trichomonas vaginalis glucose transporter, putative 0.01 0.0638 0.286
Plasmodium falciparum calcium-dependent protein kinase 3 0.01 0.0636 0.0654
Echinococcus granulosus cpg binding protein 0.0031 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0061 0.036 0.5686
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.1106
Trypanosoma brucei glucose transporter, putative 0.01 0.0638 0.8747
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Echinococcus granulosus expressed conserved protein 0.0189 0.1273 0.1273
Schistosoma mansoni lysyl-tRNA synthetase 0.0072 0.0438 0.0438
Plasmodium vivax threonine--tRNA ligase, putative 0.0018 0.0052 0.0053
Echinococcus granulosus General substrate transporter 0.0278 0.1907 0.1907
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.1106
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0061 0.036 1
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0153 0.0236
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.004 0.0206 0.0925
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0024 0.0323
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0037 0.0165
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0059 0.2381
Mycobacterium ulcerans hypothetical protein 0.0049 0.0268 0.1393
Trypanosoma brucei unspecified product 0.002 0.0063 0.0869
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0272 0.0272
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.01 0.0636 0.0636
Trypanosoma brucei THT1 - hexose transporter, putative 0.01 0.0638 0.8747
Trichomonas vaginalis sugar transporter, putative 0.01 0.0638 0.286
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0187 0.1375
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0037 0.0504
Entamoeba histolytica hypothetical protein 0.0037 0.0186 0.1366
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0046 0.0247 0.1281
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0046 0.0247 0.0254
Loa Loa (eye worm) patched family protein 0.0012 0.0009 0.0041
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.01 0.0636 0.0654
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.01 0.0636 0.0636
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0063 0.0063
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0024 0.0037
Trypanosoma brucei glucose transporter, putative 0.01 0.0638 0.8747
Schistosoma mansoni protein kinase 0.01 0.0636 0.0636
Toxoplasma gondii transporter, major facilitator family protein 0.0046 0.0247 0.0382
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0037 0.0037
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0046 0.0247 0.6772
Brugia malayi jmjC domain containing protein 0.0016 0.0037 0.0125
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.01 0.0636 0.0654
Leishmania major glucose transporter, lmgt1 0.01 0.0638 0.8747
Trypanosoma cruzi hexose transporter, putative 0.0055 0.0314 0.4296
Entamoeba histolytica protein kinase, putative 0.01 0.0636 0.4677
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0187 0.029
Schistosoma mansoni lysyl-tRNA synthetase 0.0072 0.0438 0.0438
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0181 0.0186
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.01 0.0636 0.285
Loa Loa (eye worm) major facilitator superfamily transporter 0.0046 0.0247 0.1106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Plasmodium vivax glycine--tRNA ligase, putative 0.0018 0.0052 0.0053
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0018 0.0052 0.0711
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0018 0.0052 0.0192
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0111 0.071 0.9732
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0268 0.3675
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0059 0.1406
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.002 0.0267
Echinococcus multilocularis General substrate transporter 0.0278 0.1907 0.1907
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Schistosoma mansoni DNA polymerase eta 0.0046 0.025 0.025
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0059 0.0263
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0187 0.0838
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0024 0.0065
Schistosoma mansoni alpha glucosidase 0.0037 0.0187 0.0187
Leishmania major DNA polymerase kappa, putative 0.002 0.0063 0.0869
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0037 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0869
Leishmania major hypothetical protein, conserved 0.0016 0.0037 0.0504
Toxoplasma gondii sugar transporter ST2 0.0046 0.0247 0.0382
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0525 0.3661 0.3762
Mycobacterium ulcerans hypothetical protein 0.0016 0.0037 0.0191
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0097 0.0615 0.0615
Giardia lamblia Lysyl-tRNA synthetase 0.0072 0.0438 0.5858
Toxoplasma gondii patched family protein 0.0012 0.0009 0.0014
Trypanosoma cruzi hexose transporter 0.01 0.0638 0.8747
Onchocerca volvulus 0.0046 0.0247 0.3937
Toxoplasma gondii protein kinase, putative 0.0917 0.6455 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0046 0.0247 0.3381
Onchocerca volvulus 0.0046 0.0247 0.3937
Plasmodium falciparum threonine--tRNA ligase 0.0018 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0037 0.0165
Schistosoma mansoni sugar transporter 0.0046 0.0247 0.0247
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0365 0.0365
Brugia malayi Major Facilitator Superfamily protein 0.0046 0.0247 0.1069
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0059 0.0805
Brugia malayi Major Facilitator Superfamily protein 0.0046 0.0247 0.1069
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0365 0.0365
Echinococcus granulosus solute carrier family 22 0.0046 0.0247 0.0247
Onchocerca volvulus 0.0046 0.0247 0.3937
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0636 0.285
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0106
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0111 0.071 0.9732
Leishmania major DNA polymerase eta, putative 0.0032 0.0153 0.2091
Loa Loa (eye worm) hypothetical protein 0.0046 0.025 0.1121
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0065
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0037 0.0223
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0046 0.0247 0.0247
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0024 0.0123
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0024 0.0037
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0059 0.0305
Leishmania major hypothetical protein, conserved 0.0016 0.0037 0.0506
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0403
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0131 0.0586
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0024 0.0106
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Giardia lamblia Kinase, CMGC MAPK 0.0111 0.071 1
Echinococcus multilocularis solute carrier family 22 0.0046 0.0247 0.0247
Schistosoma mansoni glycyl-tRNA synthetase 0.0018 0.0052 0.0052
Schistosoma mansoni ap endonuclease 0.0019 0.0059 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0869
Trypanosoma cruzi hexose transporter, putative 0.01 0.0638 0.8747
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0181 0.0938
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0123
Toxoplasma gondii patched family protein 0.0012 0.0009 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.071 0.3182
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0024 0.0323
Onchocerca volvulus 0.0046 0.0247 0.3937
Giardia lamblia DINP protein human, muc B family 0.002 0.0063 0.0175
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0187 0.0838
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Echinococcus multilocularis solute carrier family 22 0.0046 0.0247 0.0247
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0024 0.0174
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0037 0.0038
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0024 0.0037
Mycobacterium ulcerans sugar transporter 0.0046 0.0247 0.1281
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0049 0.0049
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0024 0.0123
Echinococcus multilocularis Niemann Pick C1 protein 0.0202 0.136 0.136
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0018 0.0052 0.0233
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0061 0.036 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.1376 0.9733 1
Echinococcus granulosus Protein patched homolog 1 0.0087 0.0539 0.0539
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0869
Loa Loa (eye worm) patched family protein 0.0012 0.0009 0.0041
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0111 0.071 0.9732
Schistosoma mansoni sugar transporter 0.0046 0.0247 0.0247
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0268 0.1393
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0018 0.0052 0.027
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0037 0.0057
Plasmodium falciparum calcium-dependent protein kinase 1 0.01 0.0636 0.0654
Schistosoma mansoni hypothetical protein 0.0324 0.2232 0.2232
Loa Loa (eye worm) hypothetical protein 0.0049 0.0268 0.1202
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0018 0.0052 0.0382
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.1106
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0403
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0097 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0097 0.0615 0.0615
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0046 0.0247 1
Brugia malayi hypothetical protein 0.0037 0.0186 0.0794
Loa Loa (eye worm) hypothetical protein 0.0016 0.0038 0.0168
Schistosoma mansoni glutaminase 0.0281 0.1926 0.1926
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0065
Schistosoma mansoni alpha-glucosidase 0.0144 0.095 0.095
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0063 0.0063
Trypanosoma brucei glucose transporter 1E 0.01 0.0638 0.8747
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0187 0.0838
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0035 0.0172 0.077
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.01 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.1106
Onchocerca volvulus 0.0049 0.0268 0.4292
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0272 0.0272
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0037 0.0779
Echinococcus multilocularis dna polymerase eta 0.0046 0.025 0.025
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0172 0.0732
Loa Loa (eye worm) hypothetical protein 0.0049 0.0268 0.1202
Brugia malayi jmjC domain containing protein 0.0062 0.0365 0.1601
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0324 0.2232 0.2232
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0037 0.0504
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0287 0.1288
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0187 0.0838
Schistosoma mansoni hypothetical protein 0.0417 0.2897 0.2897
Echinococcus multilocularis synaptic vesicle 2 protein 0.0046 0.0247 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0539 0.2415
Echinococcus multilocularis microtubule associated protein 2 0.1414 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0869
Brugia malayi Sugar transporter family protein 0.0046 0.0247 0.1069
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0324 0.2232 0.2232
Echinococcus granulosus phd:f box containing protein 0.0016 0.0037 0.0037
Onchocerca volvulus 0.0046 0.0247 0.3937
Schistosoma mansoni hypothetical protein 0.0083 0.0517 0.0517
Toxoplasma gondii patched family protein 0.0012 0.0009 0.0014
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0059 0.0805
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0063 0.0466
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0268 0.1393
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.071 0.3182
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.002 0.0267
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0024 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0247 0.1106
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.1106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0181 0.0186
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0093
Plasmodium falciparum calcium-dependent protein kinase 4 0.01 0.0636 0.0654
Echinococcus multilocularis cpg binding protein 0.0031 0.0143 0.0143
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.032 0.1399
Loa Loa (eye worm) hypothetical protein 0.0051 0.0287 0.1288
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0187 0.0838
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Onchocerca volvulus 0.0097 0.0613 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0187 0.0838
Leishmania major hypothetical protein, conserved 0.0016 0.0037 0.0504
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0187 0.0187
Entamoeba histolytica hypothetical protein 0.0037 0.0186 0.1366
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0024 0.0323
Echinococcus granulosus lysyl tRNA synthetase 0.0072 0.0438 0.0438
Echinococcus granulosus calcium dependent protein kinase 0.0093 0.0586 0.0586
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0247 0.1106
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0353 0.0353
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0021 0.0052
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0024 0.0403
Echinococcus multilocularis mitogen activated protein kinase 0.0111 0.071 0.071
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0038
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0018 0.0052 0.0479
Schistosoma mansoni patched 1 0.0087 0.0539 0.0539
Onchocerca volvulus 0.0046 0.0247 0.3937
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Schistosoma mansoni jumonji domain containing protein 0.006 0.0353 0.0353
Trichomonas vaginalis sugar transporter, putative 0.01 0.0638 0.286
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0024 0.0123
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0024 0.0106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0113 0.073 0.1131
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0037 0.0037
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.032 0.032
Schistosoma mansoni cpg binding protein 0.0031 0.0143 0.0143
Brugia malayi CHE-14 protein 0.0087 0.0539 0.2384
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0021 0.0283
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0287 0.1252
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Brugia malayi Sugar transporter family protein 0.0046 0.0247 0.1069
Loa Loa (eye worm) hypothetical protein 0.0036 0.0181 0.0809
Plasmodium falciparum calcium-dependent protein kinase 5 0.01 0.0636 0.0654
Trypanosoma brucei unspecified product 0.0014 0.002 0.0267
Brugia malayi Niemann-Pick C1 protein precursor 0.0202 0.136 0.6076
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0024 0.0403
Echinococcus multilocularis protein patched 0.0087 0.0539 0.0539
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0072 0.0438 0.5996
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0037 0.0057
Echinococcus granulosus solute carrier family 22 0.0046 0.0247 0.0247
Toxoplasma gondii lysine-tRNA ligase 0.0072 0.0438 0.0678
Trypanosoma cruzi hexose transporter, putative 0.01 0.0638 0.8747
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0072 0.0438 0.5996
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Brugia malayi glutaminase DH11.1 0.0281 0.1926 0.8623
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0268 0.7384
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0272 0.1217
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0123
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1116 0.1116
Echinococcus granulosus Niemann Pick C1 protein 0.0202 0.136 0.136
Chlamydia trachomatis proline--tRNA ligase 0.0034 0.0167 0.3811
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Schistosoma mansoni microtubule-associated protein tau 0.1414 1 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0525 0.3661 0.5672
Loa Loa (eye worm) hypothetical protein 0.0202 0.136 0.6092
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0365 0.0365
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0638 0.286
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0063 0.0284
Plasmodium vivax proline--tRNA ligase, putative 0.0113 0.073 0.075
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0021 0.0093
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0123
Loa Loa (eye worm) hypothetical protein 0.0016 0.0037 0.0165
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0021 0.0093
Entamoeba histolytica protein kinase, putative 0.01 0.0636 0.4677
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0063 0.154
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0052 0.0711
Trypanosoma brucei THT1 - hexose transporter, putative 0.01 0.0638 0.8747
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0063 0.0284
Entamoeba histolytica hypothetical protein 0.0072 0.0438 0.3218
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0113 0.073 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0287 0.1252
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0059 0.006
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0187 0.0838
Schistosoma mansoni cpg binding protein 0.0029 0.0131 0.0131
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0024 0.0123
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0018 0.0052 0.0233
Giardia lamblia Prolyl-tRNA synthetase 0.0097 0.0615 0.8553
Entamoeba histolytica hypothetical protein 0.0037 0.0186 0.1366
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0187 0.2562
Chlamydia trachomatis threonine--tRNA ligase 0.0018 0.0052 0.1186
Loa Loa (eye worm) hypothetical protein 0.0036 0.0181 0.0809
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.071 0.3182
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0024 0.0323
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0097 0.0615 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0268 0.1393
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0353 0.0353
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0059 0.3523
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0111 0.071 0.9732
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0869
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0024 0.0323
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0272 0.4349
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0024 0.0123
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0038 0.0168
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0063 0.0063
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0063 0.0869
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.1106
Onchocerca volvulus 0.0014 0.0024 0.024
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0827 0.582 0.582
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0021 0.0152
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0205 0.1382 0.1382
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0202 0.136 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0097 0.0615 0.2726
Plasmodium falciparum calcium-dependent protein kinase 2 0.01 0.0636 0.0654
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.1106
Onchocerca volvulus 0.0046 0.0247 0.3937
Onchocerca volvulus 0.0046 0.0247 0.3937
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0037 0.0504
Loa Loa (eye worm) hypothetical protein 0.0016 0.0037 0.0165
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0268 0.1972
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0187 0.0838
Brugia malayi mbt repeat family protein 0.0049 0.0272 0.1181
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0024 0.0065
Schistosoma mansoni hypothetical protein 0.0083 0.0517 0.0517
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0272 0.0272
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.01 0.0636 0.0636
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0187 0.2562
Brugia malayi Sugar transporter family protein 0.0324 0.2232 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0247 0.1106
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0037 0.0037
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.071 0.3182
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.1106
Echinococcus granulosus mitogen activated protein kinase 3 0.0111 0.071 0.071
Loa Loa (eye worm) sugar transporter 0.0324 0.2232 1
Loa Loa (eye worm) oxidoreductase 0.0014 0.0024 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0037 0.0165
Brugia malayi Cam kinase protein 1 0.01 0.0636 0.282
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0024 0.0106
Toxoplasma gondii patched family protein 0.0012 0.0009 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Plasmodium vivax calcium-dependent protein kinase, putative 0.01 0.0636 0.0654
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0093
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0186 0.0186
Onchocerca volvulus 0.0046 0.0247 0.3937
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0113 0.073 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0324 0.2232 0.2232
Leishmania major protein kinase, putative 0.01 0.0636 0.8715
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0181 0.4886
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0037 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0123
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.01 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.1106
Trypanosoma brucei glucose transporter, putative 0.01 0.0638 0.8747
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0063 0.0284
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.1106
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0167 0.4483
Echinococcus multilocularis Niemann Pick C1 protein 0.0288 0.1977 0.1977
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0038 0.0038
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0272 0.0272
Loa Loa (eye worm) glutaminase 2 0.0281 0.1926 0.8628
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0072 0.0438 0.7
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.1106
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0272 0.0272
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0111 0.071 0.9732
Trypanosoma brucei glucose transporter, putative 0.01 0.0638 0.8747
Loa Loa (eye worm) hypothetical protein 0.0051 0.0284 0.1275
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0111 0.071 0.3182
Loa Loa (eye worm) hypothetical protein 0.0097 0.0615 0.2755
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0097 0.0615 0.0615
Loa Loa (eye worm) sugar transporter 0.0046 0.0247 0.1106
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0268 0.1393
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0167 0.4483
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.1327 0.1327
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0024 0.0323
Trichomonas vaginalis glucose transporter, putative 0.0046 0.0247 0.1106
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0324 0.2232 0.2232
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0063 0.0869
Onchocerca volvulus 0.0014 0.0024 0.024
Giardia lamblia Sugar-proton symporter 0.0046 0.0247 0.296
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0268 0.1393
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0087 0.0539 0.2415
Loa Loa (eye worm) hypothetical protein 0.0036 0.0181 0.0809
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.1116 0.1116
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0024 0.0106
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0123
Echinococcus multilocularis expressed conserved protein 0.0189 0.1273 0.1273
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0268 0.1972
Trichomonas vaginalis sugar transport protein, putative 0.0046 0.0247 0.1106
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0063 0.0869
Echinococcus multilocularis sterol regulatory element binding protein 0.0087 0.0539 0.0539
Onchocerca volvulus 0.0014 0.0024 0.024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0233
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0059 0.006
Echinococcus granulosus solute carrier family 22 0.0046 0.0247 0.0247
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0018 0.0052 0.0192
Echinococcus multilocularis GPCR, family 2 0.0016 0.0038 0.0038
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.032 0.032
Toxoplasma gondii hypothetical protein 0.0012 0.0009 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0268 0.3675
Onchocerca volvulus 0.0046 0.0247 0.3937
Entamoeba histolytica hypothetical protein 0.0037 0.0186 0.1366
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0037 0.0037
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0038 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.025 0.3428
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0869
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0021 0.0093
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.01 0.0636 0.282
Loa Loa (eye worm) hypothetical protein 0.0036 0.0181 0.0809
Schistosoma mansoni hypothetical protein 0.0083 0.0517 0.0517
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0059 0.0263
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0063 0.154
Brugia malayi lysyl-tRNA synthetase 0.0072 0.0438 0.1927
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0869
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Trypanosoma brucei sugar transporter, putative 0.0046 0.0247 0.3381
Leishmania major myo-inositol/proton symporter (MIT) 0.0046 0.0247 0.3381
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0063 0.0329
Brugia malayi MAP kinase sur-1 0.0111 0.071 0.3154
Schistosoma mansoni glucose transport protein 0.0324 0.2232 0.2232
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0037 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.002 0.0267
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0097 0.0615 0.2726
Echinococcus multilocularis calcium dependent protein kinase 0.0093 0.0586 0.0586
Onchocerca volvulus 0.0049 0.0272 0.4349
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.01 0.0636 0.0636
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0268 0.4136
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0113 0.073 1
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0272 0.0272
Trichomonas vaginalis sugar transporter, putative 0.01 0.0638 0.286
Echinococcus multilocularis lysyl tRNA synthetase 0.0072 0.0438 0.0438
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0063 0.0869
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0038
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0059 0.0263
Loa Loa (eye worm) MBCTL1 0.0056 0.032 0.1434
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0018 0.0052 0.1211
Loa Loa (eye worm) hypothetical protein 0.0079 0.0485 0.2173
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0037 0.0504
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0324 0.2232 0.2232
Echinococcus multilocularis protein dispatched 1 0.0099 0.0626 0.0626
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0063 0.0869
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0268 0.1165
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0021 0.0283
Plasmodium falciparum hexose transporter 0.0324 0.2232 0.2293
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0111 0.071 0.9732
Loa Loa (eye worm) hypothetical protein 0.0056 0.032 0.1434
Trypanosoma cruzi glucose transporter, putative 0.0046 0.0247 0.3381
Plasmodium vivax hexose transporter 0.0324 0.2232 0.2293
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Trypanosoma cruzi hexose transporter, putative 0.01 0.0638 0.8747
Trypanosoma brucei glucose transporter, putative 0.01 0.0638 0.8747
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0187 0.0838
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0037 0.0506
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0097 0.0615 0.2755
Treponema pallidum prolyl-tRNA synthetase 0.0034 0.0167 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0063 0.0063
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0093
Plasmodium vivax JmjC domain containing protein 0.0016 0.0037 0.0038
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0018 0.0052 0.0711
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0268 0.4136
Echinococcus granulosus sterol regulatory element binding protein 0.0087 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0869
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0024 0.0323
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0123
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0016 0.0037 0.0057
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0009 0.0009
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0018 0.0052 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0024 0.0123
Plasmodium falciparum protein kinase 6 0.1376 0.9733 1
Chlamydia trachomatis lysine--tRNA ligase 0.0072 0.0438 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0186 0.0186
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0268 0.1972
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.0093
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0181 0.4129
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0018 0.0052 0.008
Loa Loa (eye worm) glutaminase 0.0281 0.1926 0.8628
Toxoplasma gondii exonuclease III APE 0.0019 0.0059 0.0091
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0024 0.0123
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0024 0.0024
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0153 0.2091
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0063 0.0329
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0037 0.0037
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.032 0.032
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0037 0.0165
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.01 0.0636 0.0636
Onchocerca volvulus 0.0046 0.0247 0.3937
Toxoplasma gondii facilitative glucose transporter GT1 0.0324 0.2232 0.3458
Mycobacterium ulcerans glutaminase 0.0281 0.1926 1
Echinococcus granulosus mitogen activated protein kinase 0.0111 0.071 0.071
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.1106
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0038
Brugia malayi jmjC domain containing protein 0.0016 0.0037 0.0125
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.1106
Echinococcus granulosus Threonyl tRNA synthetase C 0.0018 0.0052 0.0052
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0037 0.0506
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Toxoplasma gondii sugar transporter ST1 0.0046 0.0247 0.0382
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.01 0.0636 0.0986
Schistosoma mansoni ap endonuclease 0.0019 0.0059 0.0059
Brugia malayi jmjC domain containing protein 0.006 0.0353 0.1547
Trypanosoma brucei glucose transporter 2A 0.01 0.0638 0.8747
Loa Loa (eye worm) patched family protein 0.0012 0.0009 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0059 0.0432
Echinococcus granulosus Niemann Pick C1 protein 0.0288 0.1977 0.1977
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0063 0.0869
Mycobacterium ulcerans integral membrane transport protein 0.0046 0.0247 0.1281
Trypanosoma brucei THT1 - hexose transporter, putative 0.01 0.0638 0.8747
Trypanosoma cruzi hexose transporter, putative 0.0046 0.0247 0.3381
Brugia malayi CXXC zinc finger family protein 0.0029 0.0131 0.0548
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0024 0.0403
Toxoplasma gondii sugar transporter ST3 0.0046 0.0247 0.0382
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0038
Brugia malayi glycyl-tRNA synthetase 0.0018 0.0052 0.0192
Loa Loa (eye worm) patched family protein 0.0012 0.0009 0.0041
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0638 0.286
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0063 0.0869
Echinococcus multilocularis dnaJ subfamily B 0.0417 0.2897 0.2897
Brugia malayi hypothetical protein 0.0046 0.0247 0.1069
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0024 0.0123
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0024 0.0403
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Loa Loa (eye worm) hypothetical protein 0.0049 0.0272 0.1217
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0365 0.0365
Onchocerca volvulus 0.0029 0.0131 0.2016
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0024 0.0024
Brugia malayi hypothetical protein 0.0046 0.0247 0.1069
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.1116 0.5001
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0024 0.0123
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0268 0.1393
Onchocerca volvulus 0.0014 0.0024 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0869
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0365 0.1635
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0324 0.2232 0.2232
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.032 0.032
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0024 0.0323
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0059 0.0805
Onchocerca volvulus 0.0046 0.0247 0.3937
Onchocerca volvulus 0.0046 0.0247 0.3937
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0097 0.0615 0.2755
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0049 0.0268 0.1202
Brugia malayi hypothetical protein 0.0046 0.0247 0.1069
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1116 0.1116
Echinococcus granulosus Sugar transporter ERD6 protein 0.0046 0.0247 0.0247
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.01 0.0636 0.0986
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0037 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.071 0.071
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0059 0.0223
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.032 0.032
Plasmodium falciparum protein kinase 7 0.0917 0.6455 0.6632
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0021 0.0283
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0167 0.4483
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Loa Loa (eye worm) hypothetical protein 0.0046 0.0247 0.1106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Echinococcus granulosus dna polymerase eta 0.0046 0.025 0.025
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0072 0.0438 0.2272
Brugia malayi jmjC domain containing protein 0.0016 0.0037 0.0125
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0097 0.0615 0.4523
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Leishmania major glucose transporter, lmgt3 0.01 0.0638 0.8747
Schistosoma mansoni glucose transport protein 0.0324 0.2232 0.2232
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0036 0.0181 0.0809
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0111 0.071 0.11
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.01 0.0636 0.0654
Leishmania major lysyl-tRNA synthetase, putative 0.0072 0.0438 0.5996
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0037 0.0506
Schistosoma mansoni glucose transport protein 0.0324 0.2232 0.2232
Echinococcus multilocularis solute carrier family 22 0.0046 0.0247 0.0247
Echinococcus multilocularis mitogen activated protein kinase 3 0.0111 0.071 0.071
Trichomonas vaginalis glucose transporter, putative 0.01 0.0638 0.286
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0024 0.0403
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0046 0.0247 0.6772
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0037 0.0165
Echinococcus granulosus GPCR family 2 0.0016 0.0038 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0869
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0024 0.0024
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0037 0.0037
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0059 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0041
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0187 0.1375
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0187 0.0187
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.01 0.0636 0.0636
Leishmania major threonyl-tRNA synthetase, putative 0.0018 0.0052 0.0711
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0072 0.0438 0.2272
Schistosoma mansoni hypothetical protein 0.0037 0.0186 0.0186
Onchocerca volvulus 0.0046 0.0247 0.3937
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.025 0.1084
Trypanosoma brucei protein kinase, putative 0.0111 0.071 0.9732
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0093
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.01 0.0636 0.8715
Loa Loa (eye worm) hypothetical protein 0.0072 0.0438 0.196
Trypanosoma brucei glucose transporter, putative 0.01 0.0638 0.8747
Loa Loa (eye worm) major facilitator superfamily transporter 0.0046 0.0247 0.1106
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0021 0.0093
Schistosoma mansoni hypothetical protein 0.0035 0.0172 0.0172
Echinococcus granulosus synaptic vesicle 2 protein 0.0046 0.0247 0.0247
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0024 0.0323
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.1327 0.1327
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0024 0.0403
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Trichomonas vaginalis sugar transporter, putative 0.0046 0.0247 0.1106
Plasmodium vivax patched family protein, putative 0.0012 0.0009 0.0009
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0018 0.0052 0.2103
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.1116 0.4981

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 2.6 ug ml-1 In vitro for antifungal activity against 10 yeasts ChEMBL. 9599237
MIC (functional) > 80 ug ml-1 In vitro antifungal activity against 6 filamentous fungi ChEMBL. 9599237
Protection (functional) = 0 % In vivo antifungal activity against murine candidosis model after peroral administration with 1 mg/kg at various time intervals.(percent protection for 100% mortality with fluconazole-treated group.) ChEMBL. 9599237
Protection (functional) = 0 % In vivo antifungal activity against murine candidosis model after peroral administration with 1 mg/kg at various time intervals.(percent protection for 100% mortality with fluconazole-treated group.) ChEMBL. 9599237
Protection (functional) = 10 % In vivo antifungal activity against murine candidosis model after peroral administration with 1 mg/kg at various time intervals.(percent protection for 100% mortality with untreated group) ChEMBL. 9599237
Protection (functional) = 10 % In vivo antifungal activity against murine candidosis model after peroral administration with 1 mg/kg at various time intervals.(percent protection for 100% mortality with untreated group) ChEMBL. 9599237

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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