Detailed information for compound 85080

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 168.088 | Formula: C3H9N2O4P
  • H donors: 4 H acceptors: 4 LogP: -4.88 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H](C(=O)NP(=O)(O)O)N
  • InChi: 1S/C3H9N2O4P/c1-2(4)3(6)5-10(7,8)9/h2H,4H2,1H3,(H3,5,6,7,8,9)/t2-/m1/s1
  • InChiKey: BVDGKOHLUOXAQQ-UWTATZPHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0267 0.1389
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.002 0.0087
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0055 0.0319 0.1413
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0061 0.0364 0.5694
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0322 0.2258 0.2258
Brugia malayi CXXC zinc finger family protein 0.0029 0.013 0.0541
Onchocerca volvulus 0.0014 0.0023 0.024
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.1115 0.1115
Brugia malayi major facilitator superfamily protein 0.0045 0.025 0.1073
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0023 0.0118
Echinococcus multilocularis dnaJ subfamily B 0.041 0.2897 0.2897
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0023 0.0118
Brugia malayi hypothetical protein 0.0045 0.025 0.1073
Loa Loa (eye worm) hypothetical protein 0.0048 0.0271 0.1199
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0364 0.0364
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.002 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.013 0.0575
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.025 0.1073
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0023 0.0397
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0036 0.0036
Toxoplasma gondii glycyl-tRNA synthetase 0.0018 0.0053 0.008
Trypanosoma brucei unspecified product 0.002 0.0063 0.0847
Schistosoma mansoni protein kinase 0.01 0.0643 0.0643
Loa Loa (eye worm) patched family protein 0.0012 0.0008 0.0036
Plasmodium vivax patched family protein, putative 0.0012 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.1106
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Schistosoma mansoni sugar transporter 0.0045 0.025 0.025
Loa Loa (eye worm) patched family protein 0.0012 0.0008 0.0036
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0072 0.0443 0.23
Giardia lamblia Prolyl-tRNA synthetase 0.0097 0.0622 0.8666
Mycobacterium ulcerans hypothetical protein 0.0016 0.0037 0.0193
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0319 0.0319
Toxoplasma gondii protein kinase, putative 0.0912 0.6531 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0023 0.0118
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0058 0.0256
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0171 0.0723
Onchocerca volvulus 0.0045 0.025 0.4
Onchocerca volvulus 0.0045 0.025 0.4
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.2755
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.1115 0.4939
Loa Loa (eye worm) hypothetical protein 0.0048 0.0267 0.1184
Leishmania major DNA polymerase eta, putative 0.0045 0.0249 0.3376
Toxoplasma gondii sugar transporter ST1 0.0045 0.025 0.0382
Brugia malayi jmjC domain containing protein 0.0016 0.0036 0.0123
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0037 0.0037
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0109 0.071 0.3144
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.01 0.0644 0.0986
Trypanosoma brucei unspecified product 0.0013 0.0019 0.0252
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0058 0.0058
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0023 0.0101
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0063 0.0277
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0036 0.0159
Echinococcus multilocularis GPCR, family 2 0.0016 0.0037 0.0037
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0109 0.071 0.9615
Trichomonas vaginalis glucose transporter, putative 0.01 0.0646 0.286
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0249 0.3376
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0023 0.0397
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0036 0.0036
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0796
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0109 0.071 0.9615
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.01 0.0644 0.0986
Leishmania major lysyl-tRNA synthetase, putative 0.0072 0.0443 0.5996
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Echinococcus multilocularis solute carrier family 22 0.0045 0.025 0.025
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0037 0.0504
Toxoplasma gondii facilitative glucose transporter GT1 0.0322 0.2258 0.3458
Toxoplasma gondii hypothetical protein 0.0012 0.0008 0.0013
Plasmodium falciparum calcium-dependent protein kinase 1 0.01 0.0644 0.0654
Schistosoma mansoni glucose transport protein 0.0322 0.2258 0.2258
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0194 0.1327 0.1327
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Onchocerca volvulus 0.0014 0.0023 0.024
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0018 0.0053 0.2103
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1115 0.1115
Loa Loa (eye worm) major facilitator superfamily transporter 0.0045 0.025 0.1106
Loa Loa (eye worm) hypothetical protein 0.0072 0.0443 0.196
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.01 0.0643 0.8714
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0023 0.0023
Echinococcus granulosus solute carrier family 22 0.0045 0.025 0.025
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0034 0.0169 0.0876
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0023 0.0307
Onchocerca volvulus 0.0045 0.025 0.4
Toxoplasma gondii sugar transporter ST2 0.0045 0.025 0.0382
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.8747
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0023 0.0101
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.071 0.3144
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0058 0.3428
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.01 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0796
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0186 0.1369
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0072 0.0443 0.23
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0018 0.0053 0.0711
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0186 0.0824
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0186 0.252
Trypanosoma brucei THT1 - hexose transporter, putative 0.01 0.0646 0.8747
Plasmodium vivax JmjC domain containing protein 0.0016 0.0036 0.0037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0023 0.0035
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0097 0.0622 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0023 0.0307
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0166 0.4418
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0319 0.0319
Brugia malayi hypothetical protein 0.0045 0.025 0.1073
Plasmodium vivax hexose transporter 0.0322 0.2258 0.2293
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Trypanosoma cruzi hexose transporter, putative 0.01 0.0646 0.8747
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0267 0.1151
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.002 0.0087
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.071 0.3144
Schistosoma mansoni glucose transport protein 0.0322 0.2258 0.2258
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0053 0.0711
Loa Loa (eye worm) hypothetical protein 0.0079 0.0491 0.2173
Plasmodium falciparum hexose transporter 0.0322 0.2258 0.2293
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0016 0.0037 0.0057
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0063 0.0063
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0097 0.0622 0.2729
Schistosoma mansoni lysyl-tRNA synthetase 0.0072 0.0443 0.0443
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.018 0.0183
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0267 0.1967
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0101
Loa Loa (eye worm) glutaminase 0.0276 0.1925 0.8525
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0058 0.0059
Plasmodium vivax glycine--tRNA ligase, putative 0.0018 0.0053 0.0053
Entamoeba histolytica hypothetical protein 0.0036 0.0185 0.136
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0019 0.0252
Loa Loa (eye worm) oxidoreductase 0.0014 0.0023 0.0101
Plasmodium falciparum protein kinase 6 0.1369 0.9847 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0023 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Brugia malayi jmjC domain containing protein 0.0016 0.0036 0.0123
Onchocerca volvulus 0.0014 0.0023 0.024
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0023 0.0118
Echinococcus multilocularis dna polymerase kappa 0.002 0.0063 0.0063
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0018 0.0053 0.0711
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.002 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0847
Plasmodium falciparum threonine--tRNA ligase 0.0018 0.0053 0.0053
Brugia malayi jmjC domain containing protein 0.0016 0.0036 0.0123
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0267 0.408
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0538 0.0538
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0036 0.0036
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0036 0.0055
Trypanosoma brucei protein kinase, putative 0.0109 0.071 0.9615
Mycobacterium ulcerans glutaminase 0.0276 0.1925 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.1106
Leishmania major glucose transporter/membrane transporter D2, putative 0.01 0.0646 0.8747
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.2258 1
Onchocerca volvulus 0.0045 0.025 0.4
Leishmania major DNA polymerase eta, putative 0.0032 0.0152 0.2054
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.002 0.0087
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0063 0.0325
Trypanosoma cruzi hexose transporter, putative 0.0055 0.0317 0.4296
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0036 0.0036
Echinococcus granulosus phd:f box containing protein 0.0016 0.0036 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Mycobacterium ulcerans integral membrane transport protein 0.0045 0.025 0.1297
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.01 0.0643 0.0643
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.01 0.0643 0.0643
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0058 0.0783
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0063 0.1517
Echinococcus multilocularis Niemann Pick C1 protein 0.0283 0.1976 0.1976
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0058 0.0256
Brugia malayi jmjC domain containing protein 0.0059 0.0352 0.1529
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.1106
Echinococcus granulosus Threonyl tRNA synthetase C 0.0018 0.0053 0.0053
Trypanosoma cruzi hexose transporter, putative 0.0045 0.025 0.3381
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0037 0.0037
Toxoplasma gondii patched family protein 0.0012 0.0008 0.0013
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.01 0.0644 0.0654
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0109 0.071 0.9615
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.8747
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0271 0.0271
Echinococcus granulosus lysyl tRNA synthetase 0.0072 0.0443 0.0443
Trichomonas vaginalis glutaminase, putative 0.0276 0.1925 0.8525
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.1106
Echinococcus granulosus Niemann Pick C1 protein 0.0283 0.1976 0.1976
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0036 0.0488
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.1106
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.8747
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0023 0.0307
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0063 0.0847
Trypanosoma brucei THT1 - hexose transporter, putative 0.01 0.0646 0.8747
Schistosoma mansoni hypothetical protein 0.0034 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.1106
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0023 0.0118
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0267 0.1967
Echinococcus granulosus expressed conserved protein 0.0186 0.1272 0.1272
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0023 0.0397
Trichomonas vaginalis sugar transport protein, putative 0.0045 0.025 0.1106
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0538 0.0538
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0063 0.0847
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0058 0.0426
Chlamydia trachomatis threonine--tRNA ligase 0.0018 0.0053 0.1186
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0063 0.046
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0023 0.0023
Giardia lamblia Sugar-proton symporter 0.0045 0.025 0.2999
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0023 0.0064
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0538 0.2383
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0267 0.1389
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1115 0.1115
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.018 0.4061
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0194 0.1327 0.1327
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0322 0.2258 0.2258
Trichomonas vaginalis glucose transporter, putative 0.0045 0.025 0.1106
Onchocerca volvulus 0.0014 0.0023 0.024
Giardia lamblia Kinase, CMGC MAPK 0.0109 0.071 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0284 0.1256
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0267 0.1389
Loa Loa (eye worm) sugar transporter 0.0045 0.025 0.1106
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0097 0.0622 0.2755
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0097 0.0622 0.0622
Treponema pallidum prolyl-tRNA synthetase 0.0034 0.0169 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0185 0.0185
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.01 0.0644 0.0654
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0058 0.0783
Schistosoma mansoni hypothetical protein 0.0082 0.0516 0.0516
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0847
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0045 0.025 0.6782
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.002 0.0087
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0267 0.362
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Onchocerca volvulus 0.0045 0.025 0.4
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0186 0.079
Leishmania major hypothetical protein, conserved 0.0016 0.0037 0.0504
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0036 0.0055
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0159
Echinococcus granulosus dna polymerase eta 0.0045 0.0249 0.0249
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0018 0.0053 0.0197
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0023 0.0397
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0271 0.0271
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.01 0.0643 0.2849
Echinococcus multilocularis lysyl tRNA synthetase 0.0072 0.0443 0.0443
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0319 0.1382
Schistosoma mansoni ap endonuclease 0.0019 0.0058 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0847
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0036 0.0036
Echinococcus multilocularis calcium dependent protein kinase 0.0093 0.0592 0.0592
Onchocerca volvulus 0.0048 0.0271 0.4349
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.01 0.0643 0.0643
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0113 0.0738 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0267 0.408
Trypanosoma brucei sugar transporter, putative 0.0045 0.025 0.3381
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.025 0.1073
Schistosoma mansoni glucose transport protein 0.0322 0.2258 0.2258
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.071 0.071
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0063 0.0847
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0097 0.0622 0.0622
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0159
Brugia malayi lysyl-tRNA synthetase 0.0072 0.0443 0.1931
Leishmania major DNA polymerase kappa, putative 0.002 0.0063 0.0847
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0847
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.002 0.0267
Plasmodium falciparum calcium-dependent protein kinase 5 0.01 0.0644 0.0654
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0053 0.0711
Echinococcus granulosus dna polymerase kappa 0.002 0.0063 0.0063
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0646 0.286
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0113 0.0738 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0023 0.0397
Schistosoma mansoni hypothetical protein 0.0016 0.0037 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0023 0.0118
Loa Loa (eye worm) hypothetical protein 0.0198 0.1359 0.6018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0166 0.4418
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.1115 0.4921
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0198 0.1359 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0522 0.3704 0.3762
Schistosoma mansoni microtubule-associated protein tau 0.139 1 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0061 0.0364 1
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Echinococcus multilocularis General substrate transporter 0.0277 0.193 0.193
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0072 0.0443 0.5996
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0267 0.7278
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0271 0.1199
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0019 0.0252
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0023 0.0035
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0267 0.1389
Loa Loa (eye worm) hypothetical protein 0.0097 0.0622 0.2755
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0058 0.1386
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0352 0.0352
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0847
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.071 0.3144
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0186 0.0824
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0018 0.0053 0.0386
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0185 0.0185
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0109 0.071 0.9615
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0097 0.0622 0.4578
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0186 0.0824
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0113 0.0738 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0286 0.1237
Plasmodium vivax lysine--tRNA ligase, putative 0.0072 0.0443 0.045
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.8747
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0063 0.0277
Onchocerca volvulus 0.0029 0.013 0.2017
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0058 0.0256
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0186 0.0824
Plasmodium vivax threonine--tRNA ligase, putative 0.0018 0.0053 0.0053
Trypanosoma brucei unspecified product 0.0013 0.0019 0.0252
Trypanosoma brucei glucosidase, putative 0.0037 0.0186 0.252
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0267 0.1967
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0101
Schistosoma mansoni hypothetical protein 0.0082 0.0516 0.0516
Brugia malayi mbt repeat family protein 0.0048 0.0271 0.1167
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.8747
Echinococcus granulosus Niemann Pick C1 protein 0.0198 0.1359 0.1359
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0097 0.0622 0.2729
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.1106
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0036 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0037 0.0165
Onchocerca volvulus 0.0045 0.025 0.4
Onchocerca volvulus 0.0045 0.025 0.4
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0063 0.0847
Loa Loa (eye worm) patched family protein 0.0012 0.0008 0.0036
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0023 0.0167
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.1106
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0847
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0201 0.1381 0.1381
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0023 0.0397
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0814 0.582 0.582
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0023 0.0118
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0271 0.4349
Leishmania major hypothetical protein, conserved 0.0016 0.0037 0.0504
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0023 0.0118
Onchocerca volvulus 0.0045 0.025 0.4
Schistosoma mansoni hypothetical protein 0.0036 0.0185 0.0185
Schistosoma mansoni hypothetical protein 0.0322 0.2258 0.2258
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0113 0.0738 1
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0796
Leishmania major protein kinase, putative 0.01 0.0643 0.8714
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.002 0.0267
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0023 0.0397
Brugia malayi Cam kinase protein 1 0.01 0.0643 0.2823
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0037 0.0504
Plasmodium vivax calcium-dependent protein kinase, putative 0.01 0.0644 0.0654
Schistosoma mansoni sugar transporter 0.0045 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.025 0.1106
Echinococcus multilocularis mitogen activated protein kinase 0.0109 0.071 0.071
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0036 0.0488
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0322 0.2258 0.2258
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.1106
Echinococcus granulosus mitogen activated protein kinase 3 0.0109 0.071 0.071
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0796
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Plasmodium falciparum calcium-dependent protein kinase 4 0.01 0.0644 0.0654
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0322 0.2258 0.2258
Schistosoma mansoni hypothetical protein 0.041 0.2897 0.2897
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0286 0.1269
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0186 0.0824
Echinococcus multilocularis synaptic vesicle 2 protein 0.0045 0.025 0.025
Echinococcus multilocularis microtubule associated protein 2 0.139 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0063 0.0241
Echinococcus multilocularis protein patched 0.0085 0.0538 0.0538
Schistosoma mansoni sugar transporter 0.0045 0.025 0.025
Brugia malayi Sugar transporter family protein 0.0322 0.2258 1
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0036 0.0036
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.1106
Onchocerca volvulus 0.0048 0.0267 0.4292
Loa Loa (eye worm) hypothetical protein 0.0048 0.0267 0.1184
Loa Loa (eye worm) hypothetical protein 0.0034 0.0171 0.0757
Echinococcus multilocularis dna polymerase eta 0.0045 0.0249 0.0249
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0159
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0037 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0643 0.2849
Chlamydia trachomatis proline--tRNA ligase 0.0034 0.0169 0.3811
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Loa Loa (eye worm) MBCTL1 0.0055 0.0319 0.1413
Loa Loa (eye worm) hypothetical protein 0.005 0.0286 0.1269
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0796
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0097 0.0622 0.0622
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0023 0.0023
Trypanosoma cruzi hexose transporter, putative 0.01 0.0646 0.8747
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.018 0.0934
Echinococcus granulosus cpg binding protein 0.003 0.0142 0.0142
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0109 0.071 0.9615
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.002 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0019 0.0252
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.1106
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.025 0.1106
Onchocerca volvulus 0.0045 0.025 0.4
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0037 0.0037
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0322 0.2258 0.2258
Schistosoma mansoni hypothetical protein 0.0082 0.0516 0.0516
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0063 0.0847
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0267 0.1389
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0058 0.03
Trichomonas vaginalis sugar transporter, putative 0.01 0.0646 0.286
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0352 0.0352
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0023 0.0118
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.002 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0037 0.0242
Echinococcus multilocularis mitogen activated protein kinase 3 0.0109 0.071 0.071
Onchocerca volvulus 0.0045 0.025 0.4
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0018 0.0053 0.0197
Schistosoma mansoni patched 1 0.0085 0.0538 0.0538
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0023 0.0397
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0072 0.0443 0.7006
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0037 0.0806
Echinococcus granulosus calcium dependent protein kinase 0.0093 0.0592 0.0592
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.025 0.1106
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.002 0.0145
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0023 0.0064
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0352 0.0352
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0037 0.0504
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.018 0.0183
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0186 0.0824
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0186 0.1369
Echinococcus multilocularis Niemann Pick C1 protein 0.0198 0.1359 0.1359
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0023 0.0023
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0538 0.0538
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0072 0.0443 0.5996
Toxoplasma gondii lysine-tRNA ligase 0.0072 0.0443 0.0678
Trypanosoma cruzi hexose transporter, putative 0.01 0.0646 0.8747
Leishmania major hypothetical protein, conserved 0.0045 0.025 0.3381
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0036 0.0036
Toxoplasma gondii patched family protein 0.0012 0.0008 0.0013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0286 0.1237
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0023 0.0118
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0185 0.0185
Echinococcus granulosus solute carrier family 22 0.0045 0.025 0.025
Schistosoma mansoni protein kinase 0.01 0.0643 0.0643
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.002 0.0087
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0113 0.0738 0.1131
Schistosoma mansoni hypothetical protein 0.0016 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0538 0.2383
Schistosoma mansoni cpg binding protein 0.003 0.0142 0.0142
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0319 0.0319
Brugia malayi Sugar transporter family protein 0.0045 0.025 0.1073
Brugia malayi jmjC domain containing protein 0.0061 0.0364 0.1582
Onchocerca volvulus 0.0045 0.025 0.4
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.8747
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0045 0.025 0.3381
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0018 0.0053 0.0273
Onchocerca volvulus 0.0045 0.025 0.4
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0061 0.0364 1
Brugia malayi major facilitator superfamily protein 0.0045 0.025 0.1073
Leishmania major hypothetical protein, conserved 0.0016 0.0036 0.0488
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0058 0.0059
Echinococcus granulosus solute carrier family 22 0.0045 0.025 0.025
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0045 0.025 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Schistosoma mansoni lysyl-tRNA synthetase 0.0072 0.0443 0.0443
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.01 0.0644 0.0654
Plasmodium falciparum protein kinase 7 0.0912 0.6531 0.6632
Onchocerca volvulus 0.0045 0.025 0.4
Plasmodium falciparum mitogen-activated protein kinase 2 0.0522 0.3704 0.3762
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0097 0.0622 0.0622
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0036 0.0036
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0058 0.0058
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0018 0.0053 0.0497
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0847
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.01 0.0643 0.0643
Entamoeba histolytica hypothetical protein 0.0036 0.0185 0.136
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0023 0.0118
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0023 0.0101
Schistosoma mansoni cpg binding protein 0.0029 0.013 0.013
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0023 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Echinococcus granulosus mitogen activated protein kinase 0.0109 0.071 0.071
Echinococcus multilocularis solute carrier family 22 0.0045 0.025 0.025
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0058 0.0783
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0023 0.0118
Schistosoma mansoni hypothetical protein 0.0016 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0087
Loa Loa (eye worm) hypothetical protein 0.0045 0.0249 0.1104
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0109 0.071 0.9615
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0152 0.2054
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0023 0.0118
Brugia malayi hypothetical protein 0.0045 0.025 0.1073
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0023 0.0064
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0037 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0847
Brugia malayi CHE-14 protein 0.0085 0.0538 0.2355
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0109 0.071 0.9615
Schistosoma mansoni sugar transporter 0.0045 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0267 0.1389
Echinococcus multilocularis glycyl tRNA synthetase 0.0018 0.0053 0.0053
Entamoeba histolytica protein kinase, putative 0.01 0.0643 0.4735
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0037 0.0165
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0018 0.0053 0.0233
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0364 0.0364
Brugia malayi Niemann-Pick C1 protein precursor 0.0198 0.1359 0.6003
Plasmodium vivax CDK-related protein kinase 6, putative 0.1369 0.9847 1
Echinococcus multilocularis solute carrier family 22 0.0045 0.025 0.025
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0023 0.0307
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0037 0.0126
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0023 0.0307
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.002 0.0267
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0018 0.0053 0.2103
Mycobacterium ulcerans sugar transporter 0.0045 0.025 0.1297
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.071 0.3144
Toxoplasma gondii patched family protein 0.0012 0.0008 0.0013
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0023 0.0307
Entamoeba histolytica hypothetical protein 0.0036 0.0185 0.136
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0063 0.0847
Onchocerca volvulus 0.0045 0.025 0.4
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0847
Trypanosoma brucei glucose transporter 1E 0.01 0.0646 0.8747
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0186 0.0824
Echinococcus granulosus General substrate transporter 0.0277 0.193 0.193
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0037 0.0504
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0023 0.0064
Schistosoma mansoni alpha-glucosidase 0.0142 0.0949 0.0949
Echinococcus multilocularis protein dispatched 1 0.0097 0.0625 0.0625
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0008 0.0008
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0186 0.0824
Onchocerca volvulus 0.0095 0.0612 1
Plasmodium vivax sugar transporter, putative 0.0045 0.025 0.0254
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0322 0.2258 0.2258
Loa Loa (eye worm) hypothetical protein 0.0048 0.0267 0.1184
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0048 0.0048
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0023 0.0307
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.1106
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0072 0.0443 0.196
Schistosoma mansoni alpha-glucosidase 0.0142 0.0949 0.0949
Echinococcus granulosus Sugar transporter ERD6 protein 0.0045 0.025 0.025
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.018 0.4816
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0036 0.0159
Onchocerca volvulus 0.0045 0.025 0.4
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0023 0.0118
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0063 0.1517
Plasmodium falciparum lysine--tRNA ligase 0.0072 0.0443 0.045
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.8747
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0233
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0317 0.0485
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0267 0.1151
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0048 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0063 0.0847
Onchocerca volvulus Putative transporter 0.0045 0.025 0.4
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0023 0.0307
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0267 0.1151
Echinococcus granulosus synaptic vesicle 2 protein 0.0045 0.025 0.025
Mycobacterium ulcerans hypothetical protein 0.0048 0.0267 0.1389
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0063 0.0277
Trypanosoma brucei glucose transporter 2A 0.01 0.0646 0.8747
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0271 0.0271
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.1106
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.004 0.0209 0.0925
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0152 0.0232
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0023 0.0397
Loa Loa (eye worm) hypothetical protein 0.0016 0.0037 0.0162
Brugia malayi jmjC domain containing protein 0.0016 0.0036 0.0123
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0058 0.0081
Echinococcus multilocularis expressed conserved protein 0.0186 0.1272 0.1272
Loa Loa (eye worm) patched family protein 0.0012 0.0008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.1106
Trypanosoma brucei glucose transporter, putative 0.01 0.0646 0.8747
Entamoeba histolytica hypothetical protein 0.0072 0.0443 0.3258
Brugia malayi glycyl-tRNA synthetase 0.0018 0.0053 0.0197
Brugia malayi glutaminase DH11.1 0.0276 0.1925 0.8519
Entamoeba histolytica protein kinase, putative 0.01 0.0643 0.4735
Trichomonas vaginalis glucose transporter, putative 0.01 0.0646 0.286
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Schistosoma mansoni cpg binding protein 0.003 0.0142 0.0142
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0364 0.1612
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0037 0.0504
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.025 0.1073
Brugia malayi Sugar transporter family protein 0.0045 0.025 0.1073
Trypanosoma cruzi hexose transporter 0.01 0.0646 0.8747
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0037 0.0162
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0023 0.0118
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0063 0.0063
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.01 0.0643 0.0643
Schistosoma mansoni protein kinase 0.01 0.0643 0.0643
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.01 0.0643 0.2823
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Leishmania major glucose transporter, lmgt3 0.01 0.0646 0.8747
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0186 0.0824
Trypanosoma brucei THT1 - hexose transporter, putative 0.01 0.0646 0.8747
Leishmania major glucose transporter, lmgt2 0.01 0.0646 0.8747
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0045 0.025 0.1297
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0186 0.0285
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0036 0.0036
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0045 0.025 0.025
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.002 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0186 0.252
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0058 0.0221
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0186 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.0847
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0063 0.0847
Toxoplasma gondii sugar transporter ST3 0.0045 0.025 0.0382
Schistosoma mansoni hypothetical protein 0.0016 0.0037 0.0037
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0036 0.0488
Loa Loa (eye worm) glutaminase 2 0.0276 0.1925 0.8525
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0045 0.025 0.6782
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0018 0.0053 0.0386
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0018 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Echinococcus granulosus glycyl tRNA synthetase 0.0018 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0109 0.071 0.1087
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0023 0.0307
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0058 0.2317
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0267 0.362
Plasmodium falciparum calcium-dependent protein kinase 3 0.01 0.0644 0.0654
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0319 0.0319
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.01 0.0643 0.0643
Giardia lamblia Lysyl-tRNA synthetase 0.0072 0.0443 0.5935
Schistosoma mansoni alpha glucosidase 0.0037 0.0186 0.0186
Brugia malayi hypothetical protein 0.0036 0.0185 0.0785
Trichomonas vaginalis conserved hypothetical protein 0.01 0.0646 0.286
Loa Loa (eye worm) major facilitator superfamily transporter 0.0045 0.025 0.1106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Giardia lamblia Hexose transporter 0.0045 0.025 0.2999
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0023 0.0397
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0284 0.0284
Schistosoma mansoni hypothetical protein 0.0297 0.2074 0.2074
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0045 0.025 0.025
Treponema pallidum threonyl-tRNA synthetase 0.0018 0.0053 0.3113
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0166 0.4418
Chlamydia trachomatis lysine--tRNA ligase 0.0072 0.0443 1
Entamoeba histolytica hypothetical protein 0.0036 0.0185 0.136
Brugia malayi mbt repeat family protein 0.0048 0.0271 0.1167
Leishmania major glycosyl hydrolase-like protein 0.0014 0.002 0.0267
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0063 0.0325
Echinococcus granulosus dnaJ subfamily B 0.041 0.2897 0.2897
Toxoplasma gondii patched family protein 0.0012 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0018 0.0053 0.008
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0267 0.362
Echinococcus granulosus solute carrier family 22 0.0045 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0045 0.025 0.1106
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0186 0.0186
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0166 0.4418
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0063 0.0378 0.1676
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Echinococcus multilocularis cpg binding protein 0.003 0.0142 0.0142
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0322 0.2258 0.2258
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0522 0.3704 0.5672
Onchocerca volvulus 0.0045 0.025 0.4
Plasmodium vivax proline--tRNA ligase, putative 0.0113 0.0738 0.075
Schistosoma mansoni glutaminase 0.0276 0.1925 0.1925
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0045 0.025 0.1297
Plasmodium falciparum calcium-dependent protein kinase 2 0.01 0.0644 0.0654
Onchocerca volvulus 0.005 0.0284 0.4562
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0037 0.0165
Schistosoma mansoni DNA polymerase eta 0.0045 0.0249 0.0249
Schistosoma mansoni glycyl-tRNA synthetase 0.0018 0.0053 0.0053
Leishmania major glucose transporter, lmgt1 0.01 0.0646 0.8747
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0023 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0023 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.025 0.1106
Leishmania major threonyl-tRNA synthetase, putative 0.0018 0.0053 0.0711
Echinococcus multilocularis tumor protein p63 0.0342 0.2398 0.2398
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0113 0.0738 1
Leishmania major myo-inositol/proton symporter (MIT) 0.0045 0.025 0.3381
Toxoplasma gondii transporter, major facilitator family protein 0.0045 0.025 0.0382
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0267 0.1389
Schistosoma mansoni ap endonuclease 0.0019 0.0058 0.0058
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.01 0.0644 0.0986
Trypanosoma cruzi sugar transporter, putative 0.0045 0.025 0.3381
Plasmodium falciparum proline--tRNA ligase 0.0113 0.0738 0.075
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0018 0.0053 0.0233
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0045 0.025 0.0254
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.01 0.0643 0.0643
Echinococcus granulosus tumor protein p63 0.0342 0.2398 0.2398
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0249 0.3376
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0036 0.0036
Schistosoma mansoni glucose transporter 0.0045 0.025 0.025
Loa Loa (eye worm) patched family protein 0.0012 0.0008 0.0036
Trichomonas vaginalis sugar transporter, putative 0.01 0.0646 0.286
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0643 0.0643
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0018 0.0053 0.0233
Loa Loa (eye worm) sugar transporter 0.0322 0.2258 1
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0322 0.2258 0.2258
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0023 0.0118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0267 0.7278
Trichomonas vaginalis sugar transporter, putative 0.01 0.0646 0.286
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0018 0.0053 0.1236
Echinococcus granulosus GPCR family 2 0.0016 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.025 0.1106
Loa Loa (eye worm) hypothetical protein 0.0085 0.0538 0.2383
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0186 0.0824
Toxoplasma gondii exonuclease III APE 0.0019 0.0058 0.0089
Brugia malayi MAP kinase sur-1 0.0109 0.071 0.3119
Loa Loa (eye worm) hypothetical protein 0.01 0.0643 0.2849
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0023 0.0397
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0036 0.0036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0058 0.0783
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.01 0.0643 0.2849
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0186 0.252
Loa Loa (eye worm) hypothetical protein 0.0104 0.0677 0.2998
Trypanosoma cruzi glucose transporter, putative 0.0045 0.025 0.3381
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0018 0.0053 0.0273
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0249 0.1071
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0036 0.0159
Trichomonas vaginalis sugar transporter, putative 0.0045 0.025 0.1106
Schistosoma mansoni hypothetical protein 0.0082 0.0516 0.0516
Giardia lamblia DINP protein human, muc B family 0.002 0.0063 0.0152
Trichomonas vaginalis myo-inositol transporter, putative 0.0045 0.025 0.1106
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0352 0.0352
Echinococcus multilocularis solute carrier family 22 0.0045 0.025 0.025

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 85 % Percent inhibition of DAla-DAla Ligase at 10e -3 M of the compound ChEMBL. 2502630
Inhibition (binding) = 85 % Percent inhibition of DAla-DAla Ligase at 10e -3 M of the compound ChEMBL. 2502630
Ki (binding) = 5 M Inhibition of DAla-DAla Ligase by the compound ChEMBL. 2502630

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.