Detailed information for compound 866885

Basic information

Technical information
  • TDR Targets ID: 866885
  • Name: N-(2-diethylaminoethyl)-2-[8-methyl-7-(pyrrol idine-1-carbonyl)-4,5-dihydrofuro[2,3-g]indaz ol-2-yl]acetamide
  • MW: 427.54 | Formula: C23H33N5O3
  • H donors: 1 H acceptors: 3 LogP: 2.15 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCNC(=O)Cn1cc2c(n1)c1c(CC2)oc(c1C)C(=O)N1CCCC1)CC
  • InChi: 1S/C23H33N5O3/c1-4-26(5-2)13-10-24-19(29)15-28-14-17-8-9-18-20(21(17)25-28)16(3)22(31-18)23(30)27-11-6-7-12-27/h14H,4-13,15H2,1-3H3,(H,24,29)
  • InChiKey: HJCBMJCNAGDOKS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-diethylaminoethyl)-2-[8-methyl-7-(oxo-1-pyrrolidinylmethyl)-4,5-dihydrofuro[2,3-g]indazol-2-yl]acetamide
  • N-(2-diethylaminoethyl)-2-(8-methyl-7-pyrrolidin-1-ylcarbonyl-4,5-dihydrofuro[2,3-g]indazol-2-yl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0312 0.0311
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Loa Loa (eye worm) hypothetical protein 0.0117 0.0426 0.0426
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Leishmania major pyruvate kinase 0.0036 0.0026 0.0058
Plasmodium falciparum metacaspase-like protein 0.0112 0.0401 0.1068
Schistosoma mansoni cathepsin B (C01 family) 0.0194 0.0803 0.0802
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0796 0.3757 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Onchocerca volvulus 0.0106 0.0369 0.0979
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.3808 0.3807
Schistosoma mansoni calpain-2 (C02 family) 0.0031 0.0002 0.0001
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Echinococcus multilocularis caspase 8 0.0112 0.0401 0.0399
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0161 0.0362
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0026 0.0026
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0369 0.0369
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0194 0.0803 0.2138
Loa Loa (eye worm) matrixin family protein 0.0052 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0036 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Echinococcus multilocularis cathepsin b 0.2067 1 1
Brugia malayi hypoxia-induced factor 1 0.0157 0.062 0.062
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0026 0.0064
Plasmodium falciparum serine repeat antigen 1 0.0194 0.0803 0.2138
Trypanosoma brucei calpain, putative 0.0031 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Trypanosoma cruzi metacaspase, putative 0.0112 0.0401 0.0401
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0026 0.0026
Schistosoma mansoni cathepsin C 0.0194 0.0803 0.0802
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0002 0.0001
Schistosoma mansoni microtubule-associated protein tau 0.0739 0.348 0.3479
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Trypanosoma cruzi metacaspase, putative 0.0112 0.0401 0.0401
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0796 0.3757 0.3757
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Loa Loa (eye worm) calpain D 0.0031 0.0002 0.0002
Echinococcus multilocularis neuropeptide s receptor 0.0486 0.2237 0.2236
Loa Loa (eye worm) hypothetical protein 0.02 0.0833 0.0833
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2067 1 1
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0086
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Plasmodium vivax metacaspase 1, putative 0.0112 0.0401 0.1068
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0073 0.0209 0.0209
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2067 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0438 0.2001 0.2001
Echinococcus multilocularis pyruvate kinase 0.0036 0.0026 0.0024
Plasmodium falciparum serine repeat antigen 9 0.0194 0.0803 0.2138
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0194 0.0803 0.2138
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0803 0.0803
Chlamydia trachomatis pyruvate kinase 0.0036 0.0026 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0194 0.0803 0.2134
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.0905 0.0905
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0438 0.2001 0.2
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0291 0.1278 0.1277
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0194 0.0803 0.2138
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0438 0.2001 0.2
Echinococcus multilocularis calpain 7 (C02 family) 0.0103 0.0354 0.0352
Brugia malayi Pre-SET motif family protein 0.0031 0.0002 0.0002
Brugia malayi calpain D 0.0031 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0773 0.3648 0.9709
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Entamoeba histolytica calpain large subunit domain III containing protein 0.0072 0.0203 0.0535
Echinococcus granulosus calpain 7 C02 family 0.0103 0.0354 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0226 0.0225
Giardia lamblia Cathepsin B precursor 0.0194 0.0803 0.2146
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0194 0.0803 0.0803
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0796
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Giardia lamblia Cathepsin B precursor 0.0194 0.0803 0.2146
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0438 0.2001 0.2
Trypanosoma brucei kinesin, putative 0.0072 0.0203 0.0456
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0354
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.0803 0.2134
Giardia lamblia Cathepsin B precursor 0.0773 0.3648 1
Echinococcus granulosus transient receptor potential ion channel A 0.0113 0.0407 0.0405
Plasmodium vivax vivapain-3 0.0438 0.2001 0.5326
Loa Loa (eye worm) cathepsin B 0.0773 0.3648 0.3648
Giardia lamblia Cathepsin L-like protease 0.0194 0.0803 0.2146
Echinococcus granulosus transient receptor potential gamma protein 0.0117 0.0426 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0803 0.2134
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0244 0.1048 0.1048
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0026 0.0026
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.0231 0.0229
Schistosoma mansoni cathepsin F (C01 family) 0.0552 0.2559 0.2559
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Schistosoma mansoni hypothetical protein 0.004 0.0048 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Brugia malayi MH2 domain containing protein 0.024 0.1028 0.1028
Trypanosoma cruzi cysteine peptidase, putative 0.0937 0.4449 0.4449
Schistosoma mansoni calpain (C02 family) 0.0103 0.0354 0.0353
Brugia malayi cathepsin F-like cysteine proteinase 0.0194 0.0803 0.0803
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0161 0.7387
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Leishmania major hypothetical protein, unknown function 0.0031 0.0002 0.0004
Brugia malayi hypothetical protein 0.0106 0.0369 0.0369
Brugia malayi Papain family cysteine protease containing protein 0.0438 0.2001 0.2001
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Schistosoma mansoni cathepsin s 0.0244 0.1048 0.1047
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0026 0.0066
Loa Loa (eye worm) hypothetical protein 0.2067 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.0231 0.0229
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0086
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2067 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0194 0.0803 0.2138
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0803 0.0802
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0463 0.2125 0.2125
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.0803 0.2146
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Trypanosoma brucei metacaspase MCA3 0.0112 0.0401 0.0902
Brugia malayi calpain 7 0.0103 0.0354 0.0354
Echinococcus multilocularis cathepsin L 0.0194 0.0803 0.0802
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.1028 0.1028
Loa Loa (eye worm) hypothetical protein 0.0241 0.1034 0.1034
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0044 0.0065 0.0063
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Trypanosoma cruzi cysteine proteinase, putative 0.0438 0.2001 0.2001
Schistosoma mansoni calpain C (C02 family) 0.0103 0.0354 0.0353
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0226 0.0226
Trypanosoma brucei cysteine peptidase C (CPC) 0.0773 0.3648 0.8198
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0026 0.0058
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.0803 0.2146
Trypanosoma brucei Calpain-like protein 2 0.0031 0.0002 0.0004
Echinococcus multilocularis transient receptor potential gamma protein 0.0117 0.0426 0.0424
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Trichomonas vaginalis set domain proteins, putative 0.0244 0.1051 0.2793
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0552 0.2559 0.2559
Echinococcus granulosus neuropeptide receptor A26 0.0486 0.2237 0.2236
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Onchocerca volvulus 0.0169 0.0682 0.1813
Brugia malayi cathepsin F-like cysteine proteinase 0.0244 0.1048 0.1048
Giardia lamblia Hypothetical protein 0.0194 0.0803 0.2146
Loa Loa (eye worm) calpain 5 0.0072 0.0203 0.0203
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0161 0.0159
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0194 0.0803 0.2146
Echinococcus granulosus geminin 0.0181 0.0742 0.074
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0796 0.3757 0.3756
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.0231 0.0229
Plasmodium falciparum serine repeat antigen 8 0.0194 0.0803 0.2138
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0354
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Brugia malayi Cathepsin L-like cysteine proteinase 0.0552 0.2559 0.2559
Brugia malayi PAS domain containing protein 0.0051 0.0099 0.0099
Leishmania major cathepsin L-like protease 0.0796 0.3757 0.8443
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0796 0.3757 1
Schistosoma mansoni pyruvate kinase 0.0036 0.0026 0.0025
Leishmania major cathepsin L-like protease 0.0796 0.3757 0.8443
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Trypanosoma brucei Calpain-like protein 1.2 0.0031 0.0002 0.0004
Echinococcus multilocularis cysteine protease 0.0796 0.3757 0.3756
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Loa Loa (eye worm) calpain family protein 1 0.0272 0.1186 0.1186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0773 0.3648 0.8198
Trypanosoma brucei cysteine peptidase, putative 0.0031 0.0002 0.0004
Toxoplasma gondii hypothetical protein 0.0031 0.0002 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0161 0.016
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Entamoeba histolytica hypothetical protein 0.0194 0.0803 0.2134
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Loa Loa (eye worm) cysteine protease 0.0796 0.3757 0.3757
Leishmania major calpain protease-like protein 0.0031 0.0002 0.0004
Giardia lamblia Cysteine protease 0.0194 0.0803 0.2146
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0796
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0002 0.0002
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Giardia lamblia Cysteine protease 0.0194 0.0803 0.2146
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0194 0.0803 0.0802
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.1077 0.1076
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0121 0.0445 0.0445
Plasmodium vivax unspecified product 0.0194 0.0803 0.2138
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0369 0.0369
Brugia malayi hypothetical protein 0.0037 0.0034 0.0034
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.0231 0.0229
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0226 0.0225
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0026 0.0058
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0796 0.3757 0.3757
Echinococcus granulosus peroxidasin 0.0106 0.0369 0.0367
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0073 0.0209 0.0504
Plasmodium falciparum serine repeat antigen 6 0.0194 0.0803 0.2138
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0026 0.0069
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Schistosoma mansoni hypothetical protein 0.0031 0.0002 0.0001
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0369 0.0369
Brugia malayi cathepsin Z-like cysteine proteinase 0.0194 0.0803 0.0803
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0803 0.0802
Schistosoma mansoni survival motor neuron protein 0.0051 0.0101 0.01
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Onchocerca volvulus 0.0796 0.3757 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0552 0.2559 0.2559
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0194 0.0803 0.0803
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0026 0.0026
Leishmania major cysteine peptidase A (CPA) 0.0796 0.3757 0.8443
Brugia malayi Transient-receptor-potential like protein 0.0044 0.0065 0.0065
Toxoplasma gondii cathepsin B 0.0773 0.3648 0.971
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0194 0.0803 0.0802
Leishmania major cathepsin L-like protease 0.0937 0.4449 1
Plasmodium falciparum serine repeat antigen 7 0.0194 0.0803 0.2138
Loa Loa (eye worm) hypothetical protein 0.0244 0.1048 0.1048
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0112 0.0401 0.0401
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0463 0.2125 0.2123
Trypanosoma cruzi metacaspase, putative 0.0112 0.0401 0.0401
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0073 0.0209 0.0469
Leishmania major kinesin, putative 0.0072 0.0203 0.0456
Brugia malayi hypothetical protein 0.004 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0152 0.0598 0.0598
Echinococcus granulosus caspase 8 0.0112 0.0401 0.0399
Brugia malayi fibroinase precursor 0.0194 0.0803 0.0803
Echinococcus multilocularis caspase 2 0.0152 0.0598 0.0597
Onchocerca volvulus Matrix metalloproteinase homolog 0.0048 0.0086 0.0226
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Entamoeba histolytica cysteine proteinase, putative 0.0438 0.2001 0.5323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0438 0.2001 0.4497
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0194 0.0803 0.0802
Echinococcus granulosus cathepsin L cysteine protease 0.0438 0.2001 0.1999
Plasmodium vivax proteasome subunit beta type-5, putative 0.0073 0.0209 0.0555
Echinococcus multilocularis transient receptor potential ion channel A 0.0113 0.0407 0.0405
Trypanosoma cruzi metacaspase 5, putative 0.0112 0.0401 0.0401
Echinococcus multilocularis calpain 0.0103 0.0354 0.0352
Trypanosoma cruzi major cysteine proteinase, putative 0.0335 0.1496 0.1496
Echinococcus granulosus proteasome prosome macropain 0.0073 0.0209 0.0207
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Giardia lamblia Encystation-specific protease 0.0194 0.0803 0.2146
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0254 0.1098 0.1096
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0354
Plasmodium falciparum serine repeat antigen 4 0.0194 0.0803 0.2138
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0796
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0463 0.2125 0.2123
Echinococcus multilocularis calpain 5 0.0103 0.0354 0.0352
Brugia malayi cathepsin L-like precursor 0.0552 0.2559 0.2559
Brugia malayi Pre-SET motif family protein 0.0215 0.0905 0.0905
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0194 0.0803 0.2138
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Onchocerca volvulus 0.0796 0.3757 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0079 0.0236 0.0235
Trypanosoma cruzi cysteine peptidase, putative 0.0796 0.3757 0.3757
Plasmodium vivax calpain, putative 0.0103 0.0354 0.0943
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0073 0.0209 0.055
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0291 0.1278 0.1277
Echinococcus granulosus calpain 5 0.0103 0.0354 0.0352
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Entamoeba histolytica cysteine proteinase, putative 0.0552 0.2559 0.6811
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0031 0.0002 0.0002
Echinococcus granulosus calpain 0.0103 0.0354 0.0352
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Giardia lamblia Cathepsin B precursor 0.0773 0.3648 1
Giardia lamblia Cathepsin L-like protease 0.0194 0.0803 0.2146
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0312 0.031
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0034 0.0033
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0035 0.047
Loa Loa (eye worm) hypothetical protein 0.017 0.0685 0.0685
Echinococcus granulosus cathepsin L 0.0438 0.2001 0.1999
Onchocerca volvulus 0.0031 0.0002 0.0002
Onchocerca volvulus Peroxidase homolog 0.0106 0.0369 0.0979
Brugia malayi hypothetical protein 0.017 0.0685 0.0685
Plasmodium falciparum calpain 0.0031 0.0002 0.0005
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0026 0.0066
Loa Loa (eye worm) calpain family protein 1 0.02 0.0833 0.0833
Entamoeba histolytica cysteine proteinase, putative 0.0438 0.2001 0.5323
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0272 0.1186 0.1185
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Brugia malayi calpain 5 0.0072 0.0203 0.0203
Leishmania major pyruvate kinase 0.0036 0.0026 0.0058
Onchocerca volvulus Dual oxidase homolog 0.0106 0.0369 0.0979
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2067 1 1
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0369 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0796 0.3757 1
Leishmania major cathepsin L-like protease 0.0937 0.4449 1
Loa Loa (eye worm) ctsf protein 0.0796 0.3757 0.3757
Onchocerca volvulus Matrilysin homolog 0.0048 0.0086 0.0226
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.0803 0.2134
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0773 0.3648 0.3647
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0026 0.0069
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0803 0.0803
Trypanosoma cruzi kinesin, putative 0.0072 0.0203 0.0203
Trypanosoma cruzi cysteine peptidase, putative 0.0937 0.4449 0.4449
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0161 0.016
Trypanosoma cruzi cysteine protease, putative 0.0438 0.2001 0.2001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0034 0.0033
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0086
Echinococcus multilocularis caspase 0.0254 0.1098 0.1096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0002 0.0001
Brugia malayi calpain family protein 1 0.0272 0.1186 0.1186
Plasmodium vivax serine-repeat antigen (SERA) 0.0194 0.0803 0.2138
Loa Loa (eye worm) hypothetical protein 0.004 0.0045 0.0045
Giardia lamblia Cathepsin B precursor 0.0194 0.0803 0.2146
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0354 0.0796
Leishmania major proteasome beta 5 subunit, putative 0.0073 0.0209 0.0469
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0194 0.0803 0.0803
Plasmodium vivax vivapain-1 0.0438 0.2001 0.5326
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Trypanosoma brucei Calpain-like protein CALP1.3 0.0031 0.0002 0.0004
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0161 0.7387
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0181 0.0742 0.0741
Toxoplasma gondii cathepsin CPC1 0.0194 0.0803 0.2138
Schistosoma mansoni hypothetical protein 0.0037 0.0034 0.0033
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0048 0.0046
Echinococcus granulosus caspase 3 0.0142 0.0547 0.0545
Schistosoma mansoni calpain-7 (C02 family) 0.0103 0.0354 0.0353
Schistosoma mansoni Mername-AA248 (C02 family) 0.0103 0.0354 0.0353
Brugia malayi calpain 5 0.0031 0.0002 0.0002
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0035 0.0035
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0803 0.0802
Schistosoma mansoni cathepsin S (C01 family) 0.0194 0.0803 0.0802
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Echinococcus granulosus TRP transient receptor potential channel 0.0044 0.0065 0.0063
Schistosoma mansoni hypothetical protein 0.0181 0.0742 0.0741
Loa Loa (eye worm) hypothetical protein 0.0112 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.0048
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0031 0.0002 0.0005
Onchocerca volvulus Peroxidase homolog 0.0106 0.0369 0.0979
Schistosoma mansoni single-minded 0.0051 0.0099 0.0098
Echinococcus multilocularis caspase 3 0.0142 0.0547 0.0545
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0796 0.3757 1
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0369 0.0369
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0796
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0312 0.0311
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0194 0.0803 0.2138
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0194 0.0803 0.2138
Entamoeba histolytica cysteine proteinase, putative 0.0438 0.2001 0.5323
Loa Loa (eye worm) hypothetical protein 0.0031 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0803 0.2134
Loa Loa (eye worm) hypothetical protein 0.0246 0.1058 0.1058
Trypanosoma cruzi cruzipain precursor, putative 0.0937 0.4449 0.4449
Schistosoma mansoni peroxidasin 0.0106 0.0369 0.0368
Echinococcus multilocularis calpain A 0.0291 0.1281 0.1279
Echinococcus multilocularis calpain family protein 1, d 0.02 0.0833 0.0832
Onchocerca volvulus Cathepsin L homolog 0.0796 0.3757 1
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0161 0.0159
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0002 0.0005
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0073 0.0209 0.0209
Plasmodium vivax unspecified product 0.0438 0.2001 0.5326
Trypanosoma brucei calpain, putative 0.0031 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0244 0.1048 0.1048
Brugia malayi Matrixin family protein 0.0052 0.0107 0.0107
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0101 0.0101
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0194 0.0803 0.2138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0194 0.0803 0.2138
Loa Loa (eye worm) hypothetical protein 0.0044 0.0065 0.0065
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0369 0.0369
Onchocerca volvulus 0.0796 0.3757 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0803 0.2134
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Echinococcus multilocularis pyruvate kinase 0.0036 0.0026 0.0024
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0226 0.0226
Leishmania major cathepsin L-like protease 0.0937 0.4449 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0438 0.2001 0.5323
Entamoeba histolytica cysteine proteinase 2 0.0438 0.2001 0.5323
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0002 0.0001
Brugia malayi RNA binding protein 0.0076 0.0226 0.0226
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0073 0.0209 1
Schistosoma mansoni pyruvate kinase 0.0036 0.0026 0.0025
Toxoplasma gondii cathepsin CPC2 0.0194 0.0803 0.2138
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0796 0.3757 0.3756
Echinococcus multilocularis neuropeptide receptor A26 0.0486 0.2237 0.2236
Entamoeba histolytica cysteine protease, putative 0.0194 0.0803 0.2134
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0161 0.7387
Leishmania major cathepsin L-like protease 0.0796 0.3757 0.8443
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0312 0.0312
Echinococcus multilocularis proteasome (prosome, macropain) 0.0073 0.0209 0.0207
Echinococcus multilocularis cathepsin b 0.2067 1 1
Onchocerca volvulus 0.0194 0.0803 0.2136
Schistosoma mansoni transient receptor potential channel 4 0.0117 0.0426 0.0425
Brugia malayi Proteasome A-type and B-type family protein 0.0073 0.0209 0.0209
Loa Loa (eye worm) RNA binding protein 0.0076 0.0226 0.0226
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Echinococcus granulosus tar DNA binding protein 0.0076 0.0226 0.0224
Echinococcus granulosus cathepsin l1 0.0552 0.2559 0.2558
Plasmodium vivax vivapain-2 0.0796 0.3757 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0112 0.0401 0.1068
Brugia malayi Cathepsin L-like precursor 0.0244 0.1048 0.1048
Entamoeba histolytica cysteine proteinase, putative 0.0796 0.3757 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0803 0.2134
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0226 0.0225
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Echinococcus granulosus cathepsin b 0.2067 1 1
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0401 0.1068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Onchocerca volvulus Chorion peroxidase homolog 0.0106 0.0369 0.0979
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0438 0.2001 0.4497
Echinococcus granulosus cathepsin l1 0.0796 0.3757 0.3756
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Giardia lamblia Cysteine protease 0.0194 0.0803 0.2146
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0312 0.031
Trypanosoma cruzi cysteine peptidase, putative 0.0244 0.1048 0.1048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0226 0.0225
Toxoplasma gondii cathepsin CPL 0.0796 0.3757 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0244 0.1048 0.1048
Schistosoma mansoni cathepsin F (C01 family) 0.0796 0.3757 0.3756
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.1028 0.1028
Entamoeba histolytica cysteine protease, putative 0.0796 0.3757 1
Plasmodium falciparum serine repeat antigen 2 0.0194 0.0803 0.2138
Plasmodium vivax SET domain protein, putative 0.0031 0.0002 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0194 0.0803 0.2134
Leishmania major hypothetical protein, conserved 0.0031 0.0002 0.0004
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0194 0.0803 0.2134
Trypanosoma brucei metacaspase 5, putative 0.0112 0.0401 0.0902
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0031 0.0002 0.0004
Onchocerca volvulus Peroxidasin homolog 0.0106 0.0369 0.0979
Schistosoma mansoni transient receptor potential channel 0.0078 0.0231 0.023
Echinococcus granulosus neuropeptide s receptor 0.0486 0.2237 0.2236
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0026 0.0026
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0796
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0369 0.0369
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Loa Loa (eye worm) hypothetical protein 0.0272 0.1186 0.1186
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0026 0.0026
Onchocerca volvulus 0.0796 0.3757 1
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0073 0.0209 0.055
Toxoplasma gondii proteasome subunit beta type, putative 0.0073 0.0209 0.0555
Brugia malayi Animal haem peroxidase family protein 0.0106 0.0369 0.0369
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Leishmania major metacaspase, putative 0.0112 0.0401 0.0902
Brugia malayi cathepsin Z-like cysteine proteinase 0.0194 0.0803 0.0803
Schistosoma mansoni peptidylglycine monooxygenase 0.0246 0.1058 0.1058
Trypanosoma brucei antigen, putative 0.0103 0.0354 0.0796
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Entamoeba histolytica hypothetical protein 0.0037 0.0034 0.0086
Brugia malayi Papain family cysteine protease containing protein 0.0796 0.3757 0.3757
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0035 0.0033
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0026 0.0064
Trypanosoma brucei metacaspase 0.0112 0.0401 0.0902
Echinococcus granulosus pyruvate kinase 0.0036 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0312 0.031
Brugia malayi Papain family cysteine protease containing protein 0.0438 0.2001 0.2001
Brugia malayi Cathepsin L-like precursor 0.0552 0.2559 0.2559
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Schistosoma mansoni hypothetical protein 0.0051 0.0101 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Giardia lamblia Cathepsin B precursor 0.0194 0.0803 0.2146
Echinococcus granulosus cysteine protease 0.0438 0.2001 0.1999
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0354 0.0796
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0112 0.0401 0.1068
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0354 0.0796
Onchocerca volvulus 0.0037 0.0035 0.0089
Onchocerca volvulus Cell death protein 3 homolog 0.0152 0.0598 0.1591
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0103 0.0354 0.0354
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0803 0.0803
Echinococcus multilocularis cathepsin L 0.0438 0.2001 0.1999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0048 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Schistosoma mansoni transient receptor potential channel 0.0078 0.0231 0.023
Onchocerca volvulus 0.0796 0.3757 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Schistosoma mansoni caspase-3 (C14 family) 0.0254 0.1098 0.1097
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0796 0.3757 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0773 0.3648 0.3648
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0438 0.2001 0.5323
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0079 0.0236 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0803 0.2134
Loa Loa (eye worm) hypothetical protein 0.0074 0.0212 0.0212
Echinococcus multilocularis hypothetical protein 0.0103 0.0354 0.0352
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0194 0.0803 0.2138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0438 0.2001 0.5323
Leishmania major cathepsin L-like protease 0.0796 0.3757 0.8443
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Plasmodium falciparum proteasome subunit beta type-5 0.0073 0.0209 0.0555
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0194 0.0803 0.0802
Loa Loa (eye worm) hypoxia-induced factor 1 0.0157 0.062 0.062
Plasmodium falciparum cysteine proteinase falcipain 3 0.0796 0.3757 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.0803 0.0803
Onchocerca volvulus 0.0796 0.3757 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0194 0.0803 0.0803
Loa Loa (eye worm) matrixin family protein 0.0048 0.0086 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0552 0.2559 0.6811
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0194 0.0803 0.2134
Brugia malayi Blistered cuticle protein 3 0.0106 0.0369 0.0369
Trypanosoma cruzi cruzipain precursor, putative 0.0244 0.1048 0.1048
Echinococcus granulosus caspase 2 0.0152 0.0598 0.0597
Giardia lamblia Cathepsin L precursor 0.0194 0.0803 0.2146
Plasmodium vivax unspecified product 0.0244 0.1048 0.2789
Brugia malayi Hemopexin family protein 0.0031 0.0001 0.0001
Echinococcus multilocularis cathepsin L cysteine protease 0.0796 0.3757 0.3756
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0031 0.0002 0.0002
Mycobacterium ulcerans proteasome PrcB 0.0073 0.0209 1
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Echinococcus granulosus single minded 2 0.0037 0.0035 0.0033
Echinococcus granulosus cathepsin L cysteine proteinase 0.0796 0.3757 0.3756
Echinococcus granulosus survival motor neuron protein 1 0.025 0.1077 0.1076
Schistosoma mansoni caspase-7 (C14 family) 0.0254 0.1098 0.1097
Schistosoma mansoni peroxidasin 0.0106 0.0369 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Onchocerca volvulus Cathepsin L homolog 0.0796 0.3757 1
Trypanosoma cruzi conserved protein 0.0031 0.0002 0.0002
Giardia lamblia Cathepsin B precursor 0.0773 0.3648 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0194 0.0803 0.2134
Plasmodium falciparum metacaspase 1 0.0112 0.0401 0.1068
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0803 0.0802
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0004
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0463 0.2125 0.2124
Entamoeba histolytica cysteine proteinase, putative 0.0796 0.3757 1
Trypanosoma cruzi kinesin, putative 0.0072 0.0203 0.0203
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0194 0.0803 0.2134
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0354
Giardia lamblia Hypothetical protein 0.0194 0.0803 0.2146
Echinococcus granulosus caspase 0.0254 0.1098 0.1096
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0073 0.0209 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0254 0.1098 0.1096
Plasmodium falciparum pyruvate kinase 0.0036 0.0026 0.0069
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0312 0.0312
Brugia malayi TAR-binding protein 0.0076 0.0226 0.0226
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0194 0.0803 0.2138
Toxoplasma gondii preprocathepsin c precursor, putative 0.0194 0.0803 0.2138
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0226 0.0224
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Echinococcus granulosus cathepsin b 0.2067 1 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Brugia malayi Cell death protein 3 precursor 0.0152 0.0598 0.0598
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0226 0.0225
Trypanosoma brucei hypothetical protein 0.0031 0.0002 0.0004
Trypanosoma cruzi major cysteine proteinase, putative 0.0194 0.0803 0.0803
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Schistosoma mansoni cathepsin F (C01 family) 0.0796 0.3757 0.3756
Schistosoma mansoni transient receptor potential channel 0.0117 0.0426 0.0425
Trypanosoma brucei metacaspase MCA2 0.0112 0.0401 0.0902
Trypanosoma cruzi cysteine peptidase, putative 0.0937 0.4449 0.4449
Onchocerca volvulus 0.004 0.0048 0.0124
Echinococcus granulosus cathepsin l cysteine peptidase 0.0796 0.3757 0.3756
Schistosoma mansoni caspase-7 (C14 family) 0.0152 0.0598 0.0597
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Loa Loa (eye worm) hypothetical protein 0.0169 0.0682 0.0682
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0194 0.0803 0.2146
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0031 0.0002 0.0002
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0112 0.0401 0.04
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0034 0.0033
Entamoeba histolytica cysteine proteinase, putative 0.0438 0.2001 0.5323
Onchocerca volvulus 0.0796 0.3757 1
Entamoeba histolytica protein kinase, putative 0.0072 0.0203 0.0535
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0246 0.1058 0.1058
Trypanosoma cruzi metacaspase, putative 0.0112 0.0401 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0803 0.2134
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0693 0.3252 0.3252
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0291 0.1278 0.1278
Echinococcus granulosus calpain A 0.0103 0.0354 0.0352
Trypanosoma brucei calpain-like protein, putative 0.0103 0.0354 0.0796
Loa Loa (eye worm) animal heme peroxidase 0.0106 0.0369 0.0369
Onchocerca volvulus 0.0106 0.0369 0.0979
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0112 0.0401 0.1068
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0161 0.7387
Trypanosoma cruzi cysteine peptidase, putative 0.0438 0.2001 0.2001
Echinococcus multilocularis geminin 0.0181 0.0742 0.074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Echinococcus multilocularis microtubule associated protein 2 0.0739 0.348 0.3479
Brugia malayi Cathepsin L-like precursor 0.0796 0.3757 0.3757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0354
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0291 0.1278 0.1278
Leishmania major cathepsin L-like protease 0.0796 0.3757 0.8443
Leishmania major calpain family cysteine protease-like protein 0.0031 0.0002 0.0004
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0194 0.0803 0.2138
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0312 0.0311
Brugia malayi cathepsin L precursor 0.0194 0.0803 0.0803
Echinococcus granulosus pyruvate kinase 0.0036 0.0026 0.0024
Onchocerca volvulus 0.0106 0.0369 0.0979
Onchocerca volvulus Cathepsin L homolog 0.0194 0.0803 0.2136
Onchocerca volvulus Cathepsin F homolog 0.0796 0.3757 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Plasmodium falciparum cysteine proteinase falcipain 1 0.0438 0.2001 0.5326
Entamoeba histolytica cysteine protease, putative 0.0438 0.2001 0.5323
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0073 0.0209 0.0209
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0161 0.0428
Loa Loa (eye worm) hypothetical protein 0.0796 0.3757 0.3757
Giardia lamblia Cysteine protease 0.0194 0.0803 0.2146
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0103 0.0354 0.0354
Plasmodium falciparum serine repeat antigen 3 0.0194 0.0803 0.2138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.1048 0.1048
Onchocerca volvulus 0.0552 0.2559 0.6812
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0106 0.0369 0.0369
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Schistosoma mansoni dopamine-beta-monooxygenase 0.0246 0.1058 0.1058
Loa Loa (eye worm) hypothetical protein 0.0463 0.2125 0.2125
Echinococcus granulosus cathepsin L 0.0194 0.0803 0.0802
Brugia malayi Peroxidasin 0.0106 0.0369 0.0369
Plasmodium falciparum serine repeat antigen 5 0.0194 0.0803 0.2138
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0073 0.0209 0.0208
Onchocerca volvulus 0.0051 0.0101 0.0266
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2067 1 1
Giardia lamblia Cathepsin B precursor 0.0194 0.0803 0.2146
Plasmodium vivax vivapain-2 0.0796 0.3757 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Echinococcus granulosus microtubule associated protein 2 0.0739 0.348 0.3479
Echinococcus granulosus calpain A 0.0291 0.1281 0.1279
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0369 0.0369
Plasmodium vivax serine-repeat antigen (SERA) 0.0194 0.0803 0.2138
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0026 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0002 0.0001
Onchocerca volvulus 0.0244 0.1051 0.2795
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0552 0.2559 0.6811
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Brugia malayi calpain family protein 1 0.0272 0.1186 0.1186
Trypanosoma cruzi metacaspase 5, putative 0.0112 0.0401 0.0401
Brugia malayi cathepsin L-like cysteine proteinase 0.0194 0.0803 0.0803
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0194 0.0803 0.0802
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0312 0.031
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0125 0.0464 0.0464
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0103 0.0354 0.0354
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0026 0.0066
Schistosoma mansoni calpain-7 (C02 family) 0.0103 0.0354 0.0353
Loa Loa (eye worm) fibroinase 0.0796 0.3757 0.3757
Onchocerca volvulus Peroxidasin homolog 0.0106 0.0369 0.0979
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0031 0.0002 0.0002
Echinococcus multilocularis cysteine protease 0.0796 0.3757 0.3756
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0194 0.0803 0.2138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0796 0.3757 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Trypanosoma brucei Calpain-like protein 1.1 0.0031 0.0002 0.0004
Echinococcus multilocularis peroxidasin 0.0106 0.0369 0.0367
Loa Loa (eye worm) hypothetical protein 0.025 0.1077 0.1077
Loa Loa (eye worm) calpain 0.0103 0.0354 0.0354
Brugia malayi Cathepsin L-like precursor 0.0552 0.2559 0.2559
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0937 0.4449 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0796 0.3757 0.3756
Trypanosoma brucei Metacaspase-4 0.0112 0.0401 0.0902
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0401 0.1063
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0194 0.0803 0.2134
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0002
Brugia malayi hypothetical protein 0.025 0.1077 0.1077
Loa Loa (eye worm) hypothetical protein 0.0552 0.2559 0.2559
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0438 0.2001 0.2001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0112 0.0401 0.1063
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0031 0.0002 0.0004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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