Detailed information for compound 869789

Basic information

Technical information
  • TDR Targets ID: 869789
  • Name: methyl 5-furan-2-yl-1-[2-oxo-2-(propan-2-ylam ino)ethyl]pyrrole-2-carboxylate
  • MW: 290.314 | Formula: C15H18N2O4
  • H donors: 1 H acceptors: 2 LogP: 1.86 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(n1CC(=O)NC(C)C)c1ccco1
  • InChi: 1S/C15H18N2O4/c1-10(2)16-14(18)9-17-11(13-5-4-8-21-13)6-7-12(17)15(19)20-3/h4-8,10H,9H2,1-3H3,(H,16,18)
  • InChiKey: UKOCEKNKRCQDCO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 5-(2-furyl)-1-[2-(isopropylamino)-2-oxo-ethyl]pyrrole-2-carboxylate
  • 5-(2-furyl)-1-[2-(isopropylamino)-2-oxoethyl]-2-pyrrolecarboxylic acid methyl ester
  • 5-(2-furyl)-1-[2-(isopropylamino)-2-keto-ethyl]pyrrole-2-carboxylic acid methyl ester
  • ChemDiv3_012152

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.0117 0.8636
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0006 0.0019 0.0159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0755 0.14
Brugia malayi MH2 domain containing protein 0.0017 0.0114 0.021
Echinococcus granulosus mothers against decapentaplegic 6 0.0008 0.0032 0.0028
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0006 0.0019 0.0015
Loa Loa (eye worm) aldehyde dehydrogenase 0.0006 0.0019 0.0029
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0019 0.0132 1
Schistosoma mansoni Smad4 0.0017 0.0114 0.0212
Loa Loa (eye worm) hypothetical protein 0.0006 0.0019 0.0029
Brugia malayi RNA, U transporter 1 0.0068 0.0551 0.1045
Echinococcus granulosus cpg binding protein 0.003 0.0222 0.0218
Leishmania major aldehyde dehydrogenase, putative 0.0006 0.0019 0.0159
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0436 0.0808
Echinococcus multilocularis lamin dm0 0.0027 0.0193 0.0189
Schistosoma mansoni hypothetical protein 0.0017 0.011 0.0203
Onchocerca volvulus 0.0028 0.0208 0.0464
Echinococcus multilocularis mothers against decapentaplegic 2 0.0008 0.0032 0.0028
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0481 0.0892
Schistosoma mansoni smad1 5 8 and 0.0017 0.0114 0.0212
Schistosoma mansoni hypothetical protein 0.006 0.0479 0.0887
Echinococcus granulosus netrin receptor unc 5 0.0112 0.0923 0.0919
Loa Loa (eye worm) transcription factor SMAD2 0.0255 0.2152 0.4224
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0088 0.0716 0.1401
Leishmania major GTP-binding protein, putative 0.0018 0.0117 0.1197
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0019 0.0132 1
Echinococcus multilocularis GPCR, family 2 0.0028 0.0203 0.0199
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0006 0.0019 0.0159
Schistosoma mansoni lamin 0.0027 0.0193 0.0359
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0114 0.011
Schistosoma mansoni hypothetical protein 0.0028 0.0203 0.0376
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0088 0.0716 0.1362
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0006 0.0019 0.1169
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.0117 0.8636
Schistosoma mansoni cpg binding protein 0.003 0.0222 0.0412
Trichomonas vaginalis helicase, putative 0.0006 0.002 0.1263
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0006 0.0019 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0114 0.0945 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0755 0.1477
Echinococcus multilocularis netrin receptor unc 5 0.0112 0.0923 0.0919
Brugia malayi mothers against decapentaplegic homolog 3 0.0008 0.0032 0.0053
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0006 0.0019 0.0896
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0026 0.0021
Schistosoma mansoni hypothetical protein 0.0147 0.122 0.2262
Brugia malayi CXXC zinc finger family protein 0.0028 0.0208 0.0391
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0006 0.0019 0.5
Schistosoma mansoni importin beta-1 0.0024 0.0171 0.0317
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0039 0.0068
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0085
Schistosoma mansoni netrin receptor unc5 0.0112 0.0923 0.171
Brugia malayi MH1 domain containing protein 0.0017 0.0114 0.021
Brugia malayi Smad1 0.0017 0.0114 0.021
Echinococcus granulosus dnaJ subfamily B 0.0404 0.3429 0.3426
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0615 0.5233 0.5231
Schistosoma mansoni smad 0.0017 0.0114 0.0212
Echinococcus granulosus expressed protein 0.0017 0.011 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Brugia malayi hypothetical protein 0.0483 0.4101 0.7837
Plasmodium falciparum importin beta, putative 0.0024 0.0171 1
Entamoeba histolytica Ran family GTPase 0.0018 0.0117 0.8795
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0006 0.0019 0.0159
Brugia malayi bZIP transcription factor family protein 0.0017 0.011 0.0202
Entamoeba histolytica hypothetical protein 0.0019 0.0132 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0755 0.0751
Loa Loa (eye worm) hypothetical protein 0.0024 0.0171 0.0328
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0114 0.0945 1
Schistosoma mansoni cpg binding protein 0.003 0.0222 0.0412
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0028 0.0203 0.0199
Echinococcus granulosus Smad4 0.0017 0.0114 0.011
Echinococcus multilocularis geminin 0.0147 0.122 0.1217
Echinococcus multilocularis smad 0.0017 0.0114 0.011
Schistosoma mansoni importin-beta 2 0.0005 0.0004 0.0008
Loa Loa (eye worm) histone methyltransferase 0.0009 0.004 0.0071
Mycobacterium ulcerans aldehyde dehydrogenase 0.0114 0.0945 1
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0006 0.0019 0.0015
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0028 0.0203 0.038
Treponema pallidum gamma-glutamyl phosphate reductase 0.0006 0.0019 0.5
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0006 0.0019 0.0896
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.004 0.0036
Onchocerca volvulus Huntingtin homolog 0.0106 0.0873 0.2091
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0112 0.0923 0.0919
Onchocerca volvulus Netrin receptor homolog 0.0112 0.0923 0.2213
Echinococcus multilocularis musashi 0.0027 0.0193 0.0189
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0026 0.0047
Leishmania major importin beta-1 subunit, putative 0.0019 0.0132 0.1361
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.002 0.1263
Echinococcus granulosus jun protein 0.0615 0.5233 0.5231
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0008 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0106 0.0873 0.1708
Schistosoma mansoni aldehyde dehydrogenase 0.0006 0.0019 0.0035
Schistosoma mansoni aldehyde dehydrogenase 0.0114 0.0945 0.1751
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0087 0.0164
Trichomonas vaginalis importin beta-1, putative 0.0019 0.0132 1
Schistosoma mansoni hypothetical protein 0.0257 0.2163 0.401
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0114 0.0945 1
Brugia malayi Uncoordinated protein 44 0.0112 0.0923 0.1757
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.1263
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0018 0.0117 0.6744
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0132
Echinococcus multilocularis tumor protein p63 0.0375 0.3179 0.3176
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0006 0.0019 0.0015
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0114 0.011
Loa Loa (eye worm) hypothetical protein 0.0112 0.0923 0.1807
Onchocerca volvulus Huntingtin homolog 0.0106 0.0873 0.2091
Loa Loa (eye worm) hypothetical protein 0.0008 0.0032 0.0054
Loa Loa (eye worm) bZIP transcription factor family protein 0.0017 0.011 0.0207
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0006 0.0019 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.2004 0.3934
Leishmania major aldehyde dehydrogenase, putative 0.0006 0.0019 0.0159
Brugia malayi Calcitonin receptor-like protein seb-1 0.0088 0.0716 0.1362
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0018 0.0117 0.1197
Echinococcus multilocularis cpg binding protein 0.003 0.0222 0.0218
Schistosoma mansoni intermediate filament proteins 0.0027 0.0193 0.0359
Echinococcus granulosus intermediate filament protein 0.0027 0.0193 0.0189
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.0017 0.011 0.0105
Schistosoma mansoni aldehyde dehydrogenase 0.0006 0.0019 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0006 0.0019 0.0015
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0006 0.0019 0.1169
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.002 0.1263
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0026 0.0021
Schistosoma mansoni Smad4 0.0008 0.0032 0.0059
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0017 0.011 0.0105
Schistosoma mansoni camp-response element binding protein-related 0.0017 0.011 0.0203
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0006 0.0019 0.5
Schistosoma mansoni hypothetical protein 0.0404 0.3429 0.6356
Loa Loa (eye worm) bZIP transcription factor family protein 0.0017 0.011 0.0207
Brugia malayi Importin beta-1 subunit 0.0024 0.0171 0.0319
Brugia malayi Aldehyde dehydrogenase protein 4 0.0006 0.0019 0.0029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.1263
Echinococcus multilocularis jun protein 0.0615 0.5233 0.5231
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0006 0.0019 0.0159
Schistosoma mansoni cpg binding protein 0.0028 0.0208 0.0386
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0026 0.0021
Schistosoma mansoni smad1 5 8 and 0.0017 0.0114 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0725 0.6179 0.6178
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0006 0.0019 0.0896
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0615 0.5233 0.5231
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0006 0.0019 0.0159
Echinococcus multilocularis Ankyrin 0.0112 0.0927 0.0923
Echinococcus multilocularis microtubule associated protein 2 0.0634 0.5394 0.5392
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0257 0.2163 0.4246
Schistosoma mansoni aldehyde dehydrogenase 0.0114 0.0945 0.1751
Schistosoma mansoni microtubule-associated protein tau 0.0634 0.5394 1
Brugia malayi Protein kinase domain containing protein 0.0112 0.0923 0.1757
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0018 0.0117 0.6744
Schistosoma mansoni hypothetical protein 0.0147 0.122 0.2262
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0032 0.0054
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0114 0.0945 0.0941
Echinococcus granulosus microtubule associated protein 2 0.0634 0.5394 0.5392
Brugia malayi Immunoglobulin I-set domain containing protein 0.0112 0.0923 0.1757
Onchocerca volvulus 0.0055 0.0436 0.102
Echinococcus granulosus smad 0.0017 0.0114 0.011
Schistosoma mansoni camp-response element binding protein-related 0.0017 0.011 0.0203
Loa Loa (eye worm) Smad1 0.0017 0.0114 0.0216
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0006 0.0019 0.0015
Loa Loa (eye worm) hypothetical protein 0.0112 0.0927 0.1815
Schistosoma mansoni hypothetical protein 0.0006 0.0019 0.0035
Leishmania major aldehyde dehydrogenase, putative 0.0006 0.0019 0.0159
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0006 0.0019 0.0035
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0208 0.0402
Echinococcus granulosus cAMP responsive element binding protein 3 0.0017 0.011 0.0105
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0112 0.0923 0.1807
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0006 0.0019 0.0029
Echinococcus granulosus cyclic AMP responsive element binding protein 0.0017 0.011 0.0105
Echinococcus multilocularis cAMP responsive element binding protein 3 0.0017 0.011 0.0105
Schistosoma mansoni jun-related protein 0.05 0.4246 0.7871
Loa Loa (eye worm) MH2 domain-containing protein 0.0255 0.2152 0.4224
Schistosoma mansoni hypothetical protein 0.0028 0.0203 0.0376
Onchocerca volvulus 0.0483 0.4101 1
Schistosoma mansoni aldehyde dehydrogenase 0.0006 0.0019 0.0035
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0006 0.0019 0.0015
Echinococcus granulosus GPCR family 2 0.0028 0.0203 0.0199
Echinococcus granulosus geminin 0.0147 0.122 0.1217
Loa Loa (eye worm) hypothetical protein 0.0028 0.0203 0.0391
Echinococcus multilocularis Smad4 0.0017 0.0114 0.011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0114 0.0945 1
Brugia malayi MH1 domain containing protein 0.0017 0.0114 0.021
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0006 0.0019 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0207
Schistosoma mansoni hypothetical protein 0.05 0.4246 0.7871
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0364
Brugia malayi intermediate filament protein 0.0027 0.0193 0.0362
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.1263
Loa Loa (eye worm) bZIP transcription factor family protein 0.0017 0.011 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0018 0.0117 0.0113
Schistosoma mansoni hypothetical protein 0.0028 0.0203 0.0376
Toxoplasma gondii aldehyde dehydrogenase 0.0114 0.0945 1
Echinococcus granulosus lamin dm0 0.0027 0.0193 0.0189
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0006 0.0019 0.0029
Echinococcus granulosus importin subunit beta 1 0.0024 0.0171 0.0167
Loa Loa (eye worm) hypothetical protein 0.0598 0.5088 1
Schistosoma mansoni ran 0.0018 0.0117 0.0216
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0026 0.0021
Echinococcus granulosus lamin 0.0027 0.0193 0.0189
Echinococcus granulosus cyclic AMP responsive element binding protein 0.0017 0.011 0.0105
Echinococcus multilocularis cyclic AMP dependent transcription factor ATF 6 0.0017 0.011 0.0105
Trypanosoma cruzi importin beta-1 subunit, putative 0.0019 0.0132 1
Brugia malayi MH2 domain containing protein 0.0017 0.0114 0.021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0755 0.14
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0112 0.0923 0.0919
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0114 0.0212
Echinococcus granulosus cyclic AMP dependent transcription factor ATF 6 0.0017 0.011 0.0105
Brugia malayi MH1 domain containing protein 0.001 0.0048 0.0083
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0075 0.0071
Brugia malayi latrophilin 2 splice variant baaae 0.006 0.0479 0.0908
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0018 0.0117 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0018 0.0117 0.6744
Schistosoma mansoni Smad4 0.0008 0.0032 0.0059
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0028 0.0203 0.0199
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0006 0.0019 0.1169
Schistosoma mansoni hypothetical protein 0.0028 0.0203 0.0376
Loa Loa (eye worm) latrophilin receptor protein 2 0.0028 0.0203 0.0391
Loa Loa (eye worm) hypothetical protein 0.0006 0.0019 0.0029
Brugia malayi follicle stimulating hormone receptor 0.0238 0.2004 0.3826
Schistosoma mansoni camp-response element binding protein 0.0017 0.011 0.0203
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0114 0.0216
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0112 0.0927 0.1718
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0193 0.0373
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0114 0.011
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0006 0.0019 0.0159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0755 0.14
Brugia malayi Death domain containing protein 0.0112 0.0923 0.1757
Loa Loa (eye worm) hypothetical protein 0.0013 0.0075 0.014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0028 0.0203 0.0199
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0755 0.1437
Brugia malayi aldehyde dehydrogenase 0.0006 0.0019 0.0029
Plasmodium vivax importin-beta 2, putative 0.0024 0.0171 1
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0006 0.0019 0.0015
Echinococcus granulosus GTP binding nuclear protein Ran 0.0018 0.0117 0.0113
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0017 0.011 0.0105
Echinococcus granulosus fos transcription factor 0.0017 0.011 0.0105
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0755 0.0751
Schistosoma mansoni aldehyde dehydrogenase 0.0006 0.0019 0.0035
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0114 0.0945 0.0941
Schistosoma mansoni aldehyde dehydrogenase 0.0006 0.0019 0.0035
Loa Loa (eye worm) hypothetical protein 0.0027 0.0193 0.0373
Loa Loa (eye worm) hypothetical protein 0.006 0.0479 0.0934
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0193 0.0362
Brugia malayi MH2 domain containing protein 0.0008 0.0032 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Schistosoma mansoni lamin 0.0027 0.0193 0.0359
Trypanosoma brucei importin beta-1 subunit, putative 0.0024 0.0171 1
Brugia malayi bZIP transcription factor family protein 0.0017 0.011 0.0202
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.004 0.0036
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0032 0.0054
Loa Loa (eye worm) hypothetical protein 0.0088 0.0716 0.1401
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0755 0.0751
Schistosoma mansoni smad 0.0008 0.0032 0.0059
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0018 0.0117 0.0221
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0193 0.0373
Brugia malayi bZIP transcription factor family protein 0.0017 0.011 0.0202
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0006 0.0019 0.0015
Loa Loa (eye worm) hypothetical protein 0.0106 0.0873 0.1708
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0018 0.0117 0.0215
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0006 0.0019 0.1169
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0006 0.0019 0.1169
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0207
Onchocerca volvulus 0.0027 0.0193 0.0427
Toxoplasma gondii HEAT repeat-containing protein 0.0024 0.0171 0.1775
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0006 0.0019 0.0015
Brugia malayi MH1 domain containing protein 0.001 0.0048 0.0083
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0006 0.0019 0.0029
Echinococcus granulosus snurportin 1 0.0257 0.2163 0.216
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0006 0.0019 0.0896
Echinococcus multilocularis nuclear factor of activated T cells 5 0.1172 1 1
Schistosoma mansoni ran 0.0018 0.0117 0.0216
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0755 0.0751
Echinococcus multilocularis snurportin 1 0.0257 0.2163 0.216
Schistosoma mansoni ankyrin 23/unc44 0.0112 0.0923 0.171
Echinococcus multilocularis mothers against decapentaplegic 6 0.0008 0.0032 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.1263
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.3429 0.3426
Schistosoma mansoni smad1 5 8 and 0.0017 0.0114 0.0212
Trypanosoma brucei importin beta-1 subunit, putative 0.0024 0.0171 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0008 0.0032 0.0028
Brugia malayi bZIP transcription factor family protein 0.0615 0.5233 1
Echinococcus multilocularis importin subunit beta 1 0.0024 0.0171 0.0167
Echinococcus granulosus death domain containing protein 0.0112 0.0923 0.0919
Echinococcus granulosus tumor protein p63 0.0375 0.3179 0.3176
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Schistosoma mansoni fos transcription factor-related 0.0017 0.011 0.0203
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0087 0.0159
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0114 0.011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.1263
Brugia malayi Latrophilin receptor protein 2 0.0028 0.0203 0.038
Echinococcus multilocularis fos transcription factor 0.0017 0.011 0.0105
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0114 0.0216
Schistosoma mansoni hypothetical protein 0.0112 0.0923 0.171
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0075 0.0071
Brugia malayi hypothetical protein 0.0017 0.011 0.0202
Brugia malayi MH2 domain containing protein 0.0255 0.2152 0.4108
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Loa Loa (eye worm) nuclear factor I 0.001 0.0048 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Echinococcus multilocularis lamin 0.0027 0.0193 0.0189
Trichomonas vaginalis ran, putative 0.0018 0.0117 0.8795
Onchocerca volvulus 0.0027 0.0193 0.0427
Onchocerca volvulus 0.0017 0.011 0.0222
Schistosoma mansoni camp-response element binding protein-related 0.0017 0.011 0.0203
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0006 0.0019 0.0029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.1263
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0426 0.4484
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0006 0.0019 0.0896
Echinococcus granulosus Ankyrin 0.0112 0.0927 0.0923
Loa Loa (eye worm) hypothetical protein 0.0055 0.0436 0.0849
Echinococcus multilocularis expressed protein 0.0017 0.011 0.0105
Brugia malayi bZIP transcription factor family protein 0.0017 0.011 0.0202
Brugia malayi hypothetical protein 0.0106 0.0873 0.1661
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0028 0.0203 0.0199

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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