Detailed information for compound 869789

Basic information

Technical information
  • TDR Targets ID: 869789
  • Name: methyl 5-furan-2-yl-1-[2-oxo-2-(propan-2-ylam ino)ethyl]pyrrole-2-carboxylate
  • MW: 290.314 | Formula: C15H18N2O4
  • H donors: 1 H acceptors: 2 LogP: 1.86 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(n1CC(=O)NC(C)C)c1ccco1
  • InChi: 1S/C15H18N2O4/c1-10(2)16-14(18)9-17-11(13-5-4-8-21-13)6-7-12(17)15(19)20-3/h4-8,10H,9H2,1-3H3,(H,16,18)
  • InChiKey: UKOCEKNKRCQDCO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 5-(2-furyl)-1-[2-(isopropylamino)-2-oxo-ethyl]pyrrole-2-carboxylate
  • 5-(2-furyl)-1-[2-(isopropylamino)-2-oxoethyl]-2-pyrrolecarboxylic acid methyl ester
  • 5-(2-furyl)-1-[2-(isopropylamino)-2-keto-ethyl]pyrrole-2-carboxylic acid methyl ester
  • ChemDiv3_012152

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0026 0.0047
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.002 0.1263
Loa Loa (eye worm) bZIP transcription factor family protein 0.0017 0.011 0.0207
Echinococcus granulosus snurportin 1 0.0257 0.2163 0.216
Brugia malayi MH1 domain containing protein 0.0017 0.0114 0.021
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.3429 0.3426
Echinococcus granulosus fos transcription factor 0.0017 0.011 0.0105
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0018 0.0117 0.6744
Loa Loa (eye worm) hypothetical protein 0.0013 0.0075 0.014
Brugia malayi Death domain containing protein 0.0112 0.0923 0.1757
Loa Loa (eye worm) hypothetical protein 0.0006 0.0019 0.0029
Schistosoma mansoni fos transcription factor-related 0.0017 0.011 0.0203
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0088 0.0716 0.1362
Schistosoma mansoni microtubule-associated protein tau 0.0634 0.5394 1
Schistosoma mansoni camp-response element binding protein-related 0.0017 0.011 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0114 0.011
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0207
Schistosoma mansoni hypothetical protein 0.05 0.4246 0.7871
Echinococcus granulosus GPCR family 2 0.0028 0.0203 0.0199
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0615 0.5233 0.5231
Brugia malayi Calcitonin receptor-like protein seb-1 0.0088 0.0716 0.1362
Echinococcus multilocularis cAMP responsive element binding protein 3 0.0017 0.011 0.0105
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.0117 0.8636
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0006 0.0019 0.1169
Brugia malayi MH1 domain containing protein 0.001 0.0048 0.0083
Brugia malayi MH1 domain containing protein 0.0017 0.0114 0.021
Trichomonas vaginalis helicase, putative 0.0006 0.002 0.1263
Echinococcus granulosus GTP binding nuclear protein Ran 0.0018 0.0117 0.0113
Brugia malayi bZIP transcription factor family protein 0.0017 0.011 0.0202
Brugia malayi MH2 domain containing protein 0.0255 0.2152 0.4108
Schistosoma mansoni jun-related protein 0.05 0.4246 0.7871
Loa Loa (eye worm) aldehyde dehydrogenase 0.0006 0.0019 0.0029
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0088 0.0716 0.1401
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0018 0.0117 0.0215
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0114 0.0945 0.0941
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0193 0.0373
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0006 0.0019 0.1169
Leishmania major GTP-binding protein, putative 0.0018 0.0117 0.1197
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0018 0.0117 0.0221
Echinococcus granulosus expressed protein 0.0017 0.011 0.0105
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0006 0.0019 0.5
Toxoplasma gondii HEAT repeat-containing protein 0.0024 0.0171 0.1775
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0087 0.0159
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0006 0.0019 0.0896
Loa Loa (eye worm) hypothetical protein 0.0028 0.0203 0.0391
Brugia malayi hypothetical protein 0.0106 0.0873 0.1661
Onchocerca volvulus 0.0028 0.0208 0.0464
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0028 0.0203 0.0199
Schistosoma mansoni aldehyde dehydrogenase 0.0114 0.0945 0.1751
Leishmania major aldehyde dehydrogenase, putative 0.0006 0.0019 0.0159
Echinococcus multilocularis expressed protein 0.0017 0.011 0.0105
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0018 0.0117 0.0113
Leishmania major aldehyde dehydrogenase, putative 0.0006 0.0019 0.0159
Brugia malayi hypothetical protein 0.0483 0.4101 0.7837
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0114 0.011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0114 0.0945 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0927 0.1815
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0114 0.0216
Loa Loa (eye worm) bZIP transcription factor family protein 0.0017 0.011 0.0207
Onchocerca volvulus 0.0027 0.0193 0.0427
Schistosoma mansoni hypothetical protein 0.0147 0.122 0.2262
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.0017 0.011 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0114 0.011
Schistosoma mansoni aldehyde dehydrogenase 0.0114 0.0945 0.1751
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0075 0.0071
Brugia malayi CXXC zinc finger family protein 0.0028 0.0208 0.0391
Schistosoma mansoni hypothetical protein 0.0028 0.0203 0.0376
Echinococcus granulosus Smad4 0.0017 0.0114 0.011
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0026 0.0021
Schistosoma mansoni hypothetical protein 0.0017 0.011 0.0203
Schistosoma mansoni ankyrin 23/unc44 0.0112 0.0923 0.171
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Schistosoma mansoni aldehyde dehydrogenase 0.0006 0.0019 0.0035
Trichomonas vaginalis importin beta-1, putative 0.0019 0.0132 1
Echinococcus granulosus smad 0.0017 0.0114 0.011
Onchocerca volvulus Huntingtin homolog 0.0106 0.0873 0.2091
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0006 0.0019 0.0015
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0032 0.0054
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0112 0.0923 0.0919
Echinococcus multilocularis jun protein 0.0615 0.5233 0.5231
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0725 0.6179 0.6178
Brugia malayi Smad1 0.0017 0.0114 0.021
Brugia malayi Aldehyde dehydrogenase protein 4 0.0006 0.0019 0.0029
Trypanosoma brucei importin beta-1 subunit, putative 0.0024 0.0171 1
Schistosoma mansoni lamin 0.0027 0.0193 0.0359
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0207
Loa Loa (eye worm) hypothetical protein 0.0598 0.5088 1
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0006 0.0019 0.0896
Echinococcus multilocularis mothers against decapentaplegic 6 0.0008 0.0032 0.0028
Loa Loa (eye worm) bZIP transcription factor family protein 0.0017 0.011 0.0207
Mycobacterium ulcerans aldehyde dehydrogenase 0.0114 0.0945 1
Schistosoma mansoni cpg binding protein 0.003 0.0222 0.0412
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0114 0.0945 1
Onchocerca volvulus 0.0017 0.011 0.0222
Schistosoma mansoni Smad4 0.0017 0.0114 0.0212
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0017 0.011 0.0105
Loa Loa (eye worm) nuclear factor I 0.001 0.0048 0.0085
Schistosoma mansoni netrin receptor unc5 0.0112 0.0923 0.171
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0006 0.0019 0.1169
Echinococcus multilocularis fos transcription factor 0.0017 0.011 0.0105
Schistosoma mansoni importin-beta 2 0.0005 0.0004 0.0008
Schistosoma mansoni cpg binding protein 0.0028 0.0208 0.0386
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0755 0.14
Schistosoma mansoni aldehyde dehydrogenase 0.0006 0.0019 0.0035
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0006 0.0019 0.1169
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0006 0.0019 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.1263
Loa Loa (eye worm) hypothetical protein 0.0006 0.0019 0.0029
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0006 0.0019 0.0015
Schistosoma mansoni smad1 5 8 and 0.0017 0.0114 0.0212
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0006 0.0019 0.0896
Loa Loa (eye worm) transcription factor SMAD2 0.0255 0.2152 0.4224
Echinococcus granulosus death domain containing protein 0.0112 0.0923 0.0919
Echinococcus granulosus intermediate filament protein 0.0027 0.0193 0.0189
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.1263
Brugia malayi bZIP transcription factor family protein 0.0017 0.011 0.0202
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0193 0.0362
Echinococcus multilocularis nuclear factor of activated T cells 5 0.1172 1 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0114 0.0212
Echinococcus multilocularis cpg binding protein 0.003 0.0222 0.0218
Loa Loa (eye worm) latrophilin receptor protein 2 0.0028 0.0203 0.0391
Brugia malayi aldehyde dehydrogenase 0.0006 0.0019 0.0029
Schistosoma mansoni Smad4 0.0008 0.0032 0.0059
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0193 0.0373
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0019 0.0132 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0019 0.0132 1
Echinococcus multilocularis musashi 0.0027 0.0193 0.0189
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.1263
Loa Loa (eye worm) hypothetical protein 0.0027 0.0193 0.0373
Brugia malayi hypothetical protein 0.0017 0.011 0.0202
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0006 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.0088 0.0716 0.1401
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0028 0.0203 0.0199
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0114 0.011
Brugia malayi Immunoglobulin I-set domain containing protein 0.0112 0.0923 0.1757
Echinococcus multilocularis lamin dm0 0.0027 0.0193 0.0189
Echinococcus granulosus tumor protein p63 0.0375 0.3179 0.3176
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0006 0.0019 0.0159
Brugia malayi Protein kinase domain containing protein 0.0112 0.0923 0.1757
Mycobacterium ulcerans aldehyde dehydrogenase 0.0114 0.0945 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0755 0.14
Echinococcus multilocularis cyclic AMP dependent transcription factor ATF 6 0.0017 0.011 0.0105
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0132
Onchocerca volvulus 0.0483 0.4101 1
Schistosoma mansoni Smad4 0.0008 0.0032 0.0059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0755 0.0751
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0114 0.0216
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0032 0.0054
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0006 0.0019 0.0159
Toxoplasma gondii aldehyde dehydrogenase 0.0114 0.0945 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0208 0.0402
Entamoeba histolytica Ran family GTPase 0.0018 0.0117 0.8795
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0028 0.0203 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Schistosoma mansoni cpg binding protein 0.003 0.0222 0.0412
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0426 0.4484
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0006 0.0019 0.0015
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0114 0.0945 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0075 0.0071
Brugia malayi intermediate filament protein 0.0027 0.0193 0.0362
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0755 0.14
Schistosoma mansoni camp-response element binding protein-related 0.0017 0.011 0.0203
Echinococcus granulosus lamin 0.0027 0.0193 0.0189
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0436 0.0808
Echinococcus multilocularis Ankyrin 0.0112 0.0927 0.0923
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0028 0.0203 0.038
Brugia malayi MH2 domain containing protein 0.0017 0.0114 0.021
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.002 0.1263
Leishmania major importin beta-1 subunit, putative 0.0019 0.0132 0.1361
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0114 0.0212
Brugia malayi follicle stimulating hormone receptor 0.0238 0.2004 0.3826
Schistosoma mansoni lamin 0.0027 0.0193 0.0359
Treponema pallidum gamma-glutamyl phosphate reductase 0.0006 0.0019 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0006 0.0019 0.0035
Echinococcus granulosus cyclic AMP dependent transcription factor ATF 6 0.0017 0.011 0.0105
Trypanosoma brucei importin beta-1 subunit, putative 0.0024 0.0171 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0008 0.0032 0.0031
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0018 0.0117 0.1197
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0026 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Schistosoma mansoni aldehyde dehydrogenase 0.0006 0.0019 0.0035
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.0117 0.8636
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.1263
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0006 0.0019 0.0896
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0755 0.1437
Brugia malayi mothers against decapentaplegic homolog 3 0.0008 0.0032 0.0053
Schistosoma mansoni ran 0.0018 0.0117 0.0216
Brugia malayi bZIP transcription factor family protein 0.0615 0.5233 1
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0006 0.0019 0.0015
Onchocerca volvulus Netrin receptor homolog 0.0112 0.0923 0.2213
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0755 0.1477
Plasmodium falciparum importin beta, putative 0.0024 0.0171 1
Schistosoma mansoni importin beta-1 0.0024 0.0171 0.0317
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0615 0.5233 0.5231
Echinococcus multilocularis importin subunit beta 1 0.0024 0.0171 0.0167
Schistosoma mansoni aldehyde dehydrogenase 0.0006 0.0019 0.0035
Schistosoma mansoni intermediate filament proteins 0.0027 0.0193 0.0359
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0026 0.0021
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0039 0.0068
Schistosoma mansoni hypothetical protein 0.0257 0.2163 0.401
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0257 0.2163 0.4246
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.1263
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0755 0.0751
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0006 0.0019 0.0159
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0028 0.0203 0.0199
Echinococcus multilocularis snurportin 1 0.0257 0.2163 0.216
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0364
Schistosoma mansoni ran 0.0018 0.0117 0.0216
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0755 0.0751
Echinococcus granulosus netrin receptor unc 5 0.0112 0.0923 0.0919
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0006 0.0019 0.1169
Schistosoma mansoni hypothetical protein 0.006 0.0479 0.0887
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0006 0.0019 0.5
Brugia malayi MH2 domain containing protein 0.0017 0.0114 0.021
Brugia malayi latrophilin 2 splice variant baaae 0.006 0.0479 0.0908
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0006 0.0019 0.0015
Echinococcus granulosus mothers against decapentaplegic 6 0.0008 0.0032 0.0028
Schistosoma mansoni hypothetical protein 0.0028 0.0203 0.0376
Plasmodium vivax importin-beta 2, putative 0.0024 0.0171 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0755 0.0751
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0006 0.0019 0.5
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0006 0.0019 0.0035
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0481 0.0892
Schistosoma mansoni hypothetical protein 0.0112 0.0923 0.171
Loa Loa (eye worm) hypothetical protein 0.0024 0.0171 0.0328
Loa Loa (eye worm) hypothetical protein 0.0112 0.0923 0.1807
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0006 0.0019 0.0029
Echinococcus multilocularis lamin 0.0027 0.0193 0.0189
Entamoeba histolytica hypothetical protein 0.0019 0.0132 1
Echinococcus granulosus geminin 0.0147 0.122 0.1217
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0087 0.0164
Echinococcus granulosus jun protein 0.0615 0.5233 0.5231
Echinococcus granulosus dnaJ subfamily B 0.0404 0.3429 0.3426
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0006 0.0019 0.0015
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.004 0.0036
Brugia malayi Uncoordinated protein 44 0.0112 0.0923 0.1757
Echinococcus multilocularis mothers against decapentaplegic 2 0.0008 0.0032 0.0028
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0112 0.0927 0.1718
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0006 0.0019 0.0029
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0006 0.0019 0.0896
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.004 0.0036
Loa Loa (eye worm) MH2 domain-containing protein 0.0255 0.2152 0.4224
Echinococcus multilocularis smad 0.0017 0.0114 0.011
Echinococcus granulosus cpg binding protein 0.003 0.0222 0.0218
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0112 0.0923 0.1807
Trypanosoma cruzi importin beta-1 subunit, putative 0.0019 0.0132 1
Brugia malayi bZIP transcription factor family protein 0.0017 0.011 0.0202
Loa Loa (eye worm) hypothetical protein 0.0008 0.0032 0.0054
Echinococcus granulosus Ankyrin 0.0112 0.0927 0.0923
Echinococcus granulosus mothers against decapentaplegic 2 0.0008 0.0032 0.0028
Echinococcus multilocularis netrin receptor unc 5 0.0112 0.0923 0.0919
Loa Loa (eye worm) hypothetical protein 0.0106 0.0873 0.1708
Schistosoma mansoni smad 0.0008 0.0032 0.0059
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0112 0.0923 0.0919
Schistosoma mansoni hypothetical protein 0.0404 0.3429 0.6356
Echinococcus multilocularis microtubule associated protein 2 0.0634 0.5394 0.5392
Brugia malayi MH2 domain containing protein 0.0008 0.0032 0.0053
Echinococcus granulosus cyclic AMP responsive element binding protein 0.0017 0.011 0.0105
Onchocerca volvulus Huntingtin homolog 0.0106 0.0873 0.2091
Schistosoma mansoni hypothetical protein 0.0028 0.0203 0.0376
Echinococcus multilocularis geminin 0.0147 0.122 0.1217
Leishmania major aldehyde dehydrogenase, putative 0.0006 0.0019 0.0159
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0006 0.0019 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Echinococcus granulosus lamin dm0 0.0027 0.0193 0.0189
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0006 0.0019 0.0015
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0018 0.0117 1
Echinococcus multilocularis tumor protein p63 0.0375 0.3179 0.3176
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0006 0.0019 0.0159
Echinococcus granulosus importin subunit beta 1 0.0024 0.0171 0.0167
Loa Loa (eye worm) hypothetical protein 0.0055 0.0436 0.0849
Onchocerca volvulus 0.0055 0.0436 0.102
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.002 0.1263
Schistosoma mansoni hypothetical protein 0.0006 0.0019 0.0035
Brugia malayi MH1 domain containing protein 0.001 0.0048 0.0083
Schistosoma mansoni hypothetical protein 0.0147 0.122 0.2262
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0006 0.0019 0.0015
Onchocerca volvulus 0.0027 0.0193 0.0427
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0018 0.0117 0.6744
Echinococcus granulosus cAMP responsive element binding protein 3 0.0017 0.011 0.0105
Brugia malayi bZIP transcription factor family protein 0.0017 0.011 0.0202
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0006 0.0019 0.0159
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0006 0.0019 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.002 0.1263
Schistosoma mansoni smad 0.0017 0.0114 0.0212
Echinococcus granulosus microtubule associated protein 2 0.0634 0.5394 0.5392
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0006 0.0019 0.0159
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0017 0.011 0.0105
Loa Loa (eye worm) Smad1 0.0017 0.0114 0.0216
Echinococcus multilocularis GPCR, family 2 0.0028 0.0203 0.0199
Schistosoma mansoni camp-response element binding protein 0.0017 0.011 0.0203
Loa Loa (eye worm) hypothetical protein 0.006 0.0479 0.0934
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0006 0.0019 0.0035
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0114 0.0945 0.0941
Loa Loa (eye worm) histone methyltransferase 0.0009 0.004 0.0071
Schistosoma mansoni hypothetical protein 0.0028 0.0203 0.0376
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.2004 0.3934
Brugia malayi Latrophilin receptor protein 2 0.0028 0.0203 0.038
Schistosoma mansoni smad1 5 8 and 0.0017 0.0114 0.0212
Brugia malayi Importin beta-1 subunit 0.0024 0.0171 0.0319
Trichomonas vaginalis ran, putative 0.0018 0.0117 0.8795
Echinococcus multilocularis Smad4 0.0017 0.0114 0.011
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0018 0.0117 0.6744
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0085
Loa Loa (eye worm) hypothetical protein 0.0106 0.0873 0.1708
Brugia malayi RNA, U transporter 1 0.0068 0.0551 0.1045
Schistosoma mansoni camp-response element binding protein-related 0.0017 0.011 0.0203
Echinococcus granulosus cyclic AMP responsive element binding protein 0.0017 0.011 0.0105
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0026 0.0021

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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