Detailed information for compound 90163

Basic information

Technical information
  • TDR Targets ID: 90163
  • Name: 2-tert-butyl-1-(2-methylquinolin-8-yl)-3-(1,3 -thiazol-2-yl)guanidine
  • MW: 339.458 | Formula: C18H21N5S
  • H donors: 2 H acceptors: 2 LogP: 3.59 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(n1)c(ccc2)N/C(=N\C(C)(C)C)/Nc1nccs1
  • InChi: 1S/C18H21N5S/c1-12-8-9-13-6-5-7-14(15(13)20-12)21-16(23-18(2,3)4)22-17-19-10-11-24-17/h5-11H,1-4H3,(H2,19,21,22,23)
  • InChiKey: OMZASHHCCQJEEO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-tert-butyl-1-(2-methyl-8-quinolyl)-3-thiazol-2-yl-guanidine
  • 2-tert-butyl-1-(2-methyl-8-quinolyl)-3-(2-thiazolyl)guanidine
  • 72041-95-3
  • N-(1,1-Dimethylethyl)-N'-(2-methyl-8-quinolinyl)-N''-2-thiazolylguanidine
  • BRN 5600976
  • Guanidine, 1-tert-butyl-2-(2-methyl-8-quinolyl)-3-(2-thiazolyl)-
  • Guanidine, N-(1,1-dimethylethyl)-N'-(2-methyl-8-quinolinyl)-N''-2-thiazolyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.034 0.0286 0.0817
Loa Loa (eye worm) hypothetical protein 0.005 0.0013 0.0036
Trypanosoma cruzi hexokinase, putative 0.0218 0.0171 0.0436
Plasmodium falciparum thioredoxin reductase 0.0684 0.0609 0.1741
Leishmania major farnesyl pyrophosphate synthase 0.3753 0.3498 1
Echinococcus granulosus Squalene phytoene synthase 0.0942 0.0853 0.0853
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0028 0.0028
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.1515 0.1392 0.1392
Schistosoma mansoni smad1 5 8 and 0.0044 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0077 0.0038 0.0109
Echinococcus multilocularis smad 0.0044 0.0007 0.0007
Echinococcus granulosus chromobox protein 1 0.0223 0.0175 0.0175
Brugia malayi AMP-binding enzyme family protein 0.005 0.0013 0.0036
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0181 0.0136 0.029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0001 0.0002
Trichomonas vaginalis glutamate synthase, putative 0.0181 0.0136 0.039
Loa Loa (eye worm) hypothetical protein 0.0077 0.0038 0.0109
Schistosoma mansoni sulfide quinone reductase 0.0181 0.0136 0.0136
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0038 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0049 0.014
Schistosoma mansoni cellular tumor antigen P53 0.0227 0.0179 0.0179
Schistosoma mansoni glutaminase 0.1563 0.1437 0.1437
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0013 0.0132
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0013 0.0034
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0181 0.0136 0.0136
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0181 0.0136 0.0355
Leishmania major polyprenyl synthase, putative 0.1515 0.1392 0.3956
Mycobacterium ulcerans hypothetical protein 0.005 0.0013 0.0034
Loa Loa (eye worm) polyprenyl synthetase 0.1058 0.0961 0.2749
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0033 0.0042
Onchocerca volvulus 0.0227 0.0179 0.2101
Brugia malayi cytoplasmic intermediate filament protein 0.0063 0.0025 0.0071
Mycobacterium tuberculosis Conserved protein 0.0077 0.0038 0.008
Brugia malayi MH1 domain containing protein 0.0044 0.0007 0.002
Mycobacterium tuberculosis Probable reductase 0.45 0.4202 0.8989
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0684 0.0609 0.1711
Leishmania major hypothetical protein, conserved 0.0942 0.0853 0.241
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.1058 0.0961 0.2709
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0684 0.0609 0.1741
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0181 0.0136 0.0297
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0118 0.0076 0.0219
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0181 0.0136 0.0136
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0181 0.0136 0.0338
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0181 0.0136 0.0338
Trypanosoma cruzi hexokinase, putative 0.0218 0.0171 0.0436
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0181 0.0136 0.029
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0684 0.0609 0.0609
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0181 0.0136 0.039
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0181 0.0136 0.039
Brugia malayi latrophilin 2 splice variant baaae 0.0232 0.0184 0.0527
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0181 0.0136 0.0136
Echinococcus multilocularis Squalene phytoene synthase 0.0942 0.0853 0.0853
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0038 0.0109
Brugia malayi AMP-binding enzyme family protein 0.005 0.0013 0.0036
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0181 0.0136 0.039
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.1515 0.1392 0.1392
Leishmania major hexokinase, putative 0.0218 0.0171 0.0453
Echinococcus granulosus mothers against decapentaplegic 5 0.0044 0.0007 0.0007
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0186 0.0533
Brugia malayi hexokinase type II 0.0069 0.0031 0.0088
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0038 0.0106
Trypanosoma cruzi NADH dehydrogenase, putative 0.0181 0.0136 0.0338
Brugia malayi Polyprenyl synthetase family protein 0.1058 0.0961 0.2749
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.1058 0.0961 1
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.1515 0.1392 0.3978
Trypanosoma brucei hypothetical protein, conserved 0.0181 0.0136 0.0297
Toxoplasma gondii thioredoxin reductase 0.1973 0.1823 0.5211
Brugia malayi glutamate synthase 0.0181 0.0136 0.039
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.1973 0.1823 0.3898
Brugia malayi Pre-SET motif family protein 0.0206 0.016 0.0456
Echinococcus granulosus farnesyl pyrophosphate synthase 0.3753 0.3498 0.3498
Leishmania major squalene synthase, putative 0.2848 0.2647 0.7558
Echinococcus granulosus hexokinase type 2 0.0218 0.0171 0.0171
Onchocerca volvulus 0.0098 0.0058 0.0679
Schistosoma mansoni hexokinase 0.0218 0.0171 0.0171
Trichomonas vaginalis chromobox protein, putative 0.0223 0.0175 0.0502
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0013 0.0034
Echinococcus multilocularis tumor protein p63 0.1549 0.1424 0.1424
Trypanosoma brucei hexokinase 0.0218 0.0171 0.0396
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0108 0.0067 0.0067
Treponema pallidum octaprenyl-diphosphate synthase 0.1515 0.1392 1
Echinococcus multilocularis hexokinase type 2 0.0218 0.0171 0.0171
Onchocerca volvulus 0.0181 0.0136 0.1601
Echinococcus granulosus TGF beta signal transducer SmadC 0.0044 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0181 0.0136 0.039
Onchocerca volvulus 0.0066 0.0028 0.0326
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0044 0.0007 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0645 0.0573 0.1637
Mycobacterium tuberculosis Probable oxidoreductase 0.5002 0.4674 1
Echinococcus granulosus hexokinase 0.0218 0.0171 0.0171
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0057 0.0019 0.0019
Loa Loa (eye worm) hexokinase 0.0218 0.0171 0.0488
Loa Loa (eye worm) hypothetical protein 0.0069 0.0031 0.0088
Entamoeba histolytica thioredoxin reductase, putative 0.0181 0.0136 0.1419
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0013 0.0025
Mycobacterium ulcerans hypothetical protein 0.0181 0.0136 0.0388
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0684 0.0609 0.5729
Schistosoma mansoni Smad4 0.0044 0.0007 0.0007
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0181 0.0136 0.0265
Chlamydia trachomatis thioredoxin reductase 0.0181 0.0136 0.1412
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0181 0.0136 0.039
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.1058 0.0961 0.2747
Loa Loa (eye worm) hypothetical protein 0.0098 0.0058 0.0165
Onchocerca volvulus 0.0036 0.0000000011648 0.000000013662
Brugia malayi Smad1 0.0044 0.0007 0.002
Leishmania major trypanothione reductase 0.1973 0.1823 0.5193
Mycobacterium ulcerans lipase LipD 0.0077 0.0038 0.0106
Echinococcus multilocularis microtubule associated protein 2 1.066 1 1
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.3753 0.3498 0.3498
Loa Loa (eye worm) hypothetical protein 0.0227 0.0179 0.0512
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0057 0.0019 0.0019
Schistosoma mansoni trans-prenyltransferase 0.1058 0.0961 0.0961
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0684 0.0609 0.1741
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.1058 0.0961 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0063 0.0025 0.0071
Mycobacterium tuberculosis Conserved protein 0.0077 0.0038 0.008
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0684 0.0609 0.1711
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0181 0.0136 0.1419
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0684 0.0609 0.6332
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1058 0.0961 0.2749
Loa Loa (eye worm) programmed cell death 8 0.0181 0.0136 0.039
Brugia malayi beta-lactamase 0.0077 0.0038 0.0109
Plasmodium falciparum glutathione reductase 0.1973 0.1823 0.5211
Trichomonas vaginalis chromobox protein, putative 0.0134 0.0092 0.0264
Toxoplasma gondii NADPH-glutathione reductase 0.0684 0.0609 0.1741
Echinococcus granulosus Smad4 0.0044 0.0007 0.0007
Mycobacterium ulcerans glutaminase 0.1563 0.1437 0.4106
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0038 0.0013
Trypanosoma cruzi NADH dehydrogenase, putative 0.0181 0.0136 0.0338
Loa Loa (eye worm) hexokinase type II 0.0218 0.0171 0.0488
Schistosoma mansoni disulfide oxidoreductase 0.0181 0.0136 0.0136
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0038 0.0054
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0033 0.0042
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0181 0.0136 0.039
Loa Loa (eye worm) heterochromatin protein 1 0.0223 0.0175 0.0502
Schistosoma mansoni chromobox protein 0.0223 0.0175 0.0175
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0001 0.0002
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0001 0.0002
Brugia malayi Intermediate filament tail domain containing protein 0.0118 0.0076 0.0219
Treponema pallidum hexokinase (hxk) 0.0218 0.0171 0.0273
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.5002 0.4674 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0125 0.0083 0.0977
Loa Loa (eye worm) hypothetical protein 0.0037 0.0001 0.0002
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0181 0.0136 0.0136
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0181 0.0136 0.0136
Echinococcus granulosus intermediate filament protein 0.0118 0.0076 0.0076
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.5002 0.4674 1
Leishmania major hypothetical protein, conserved 0.0181 0.0136 0.0355
Schistosoma mansoni glutamate synthase 0.0181 0.0136 0.0136
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.45 0.4202 0.8986
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0684 0.0609 0.1697
Trichomonas vaginalis esterase, putative 0.0077 0.0038 0.0109
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0038 0.008
Brugia malayi chromobox protein homolog 3 0.0125 0.0083 0.0238
Toxoplasma gondii hexokinase 0.0218 0.0171 0.0488
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0038 0.0055
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0502 0.0438 0.1253
Brugia malayi intermediate filament protein 0.0118 0.0076 0.0219
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0181 0.0136 0.0388
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0684 0.0609 0.1739
Schistosoma mansoni hypothetical protein 0.0181 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0077 0.0038 0.0109
Leishmania major hypothetical protein, conserved 0.0181 0.0136 0.0355
Loa Loa (eye worm) hypothetical protein 0.0055 0.0017 0.0049
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0044 0.0007 0.0007
Plasmodium vivax glutathione reductase, putative 0.1973 0.1823 0.5211
Giardia lamblia Farnesyl diphosphate synthase 0.3753 0.3498 1
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0181 0.0136 0.0355
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.1058 0.0961 0.2747
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.45 0.4202 0.8989
Echinococcus granulosus Chromobox protein 3 0.0036 0.0000000011648 0.0000000011648
Plasmodium falciparum hexokinase 0.0218 0.0171 0.0488
Loa Loa (eye worm) glutathione reductase 0.1973 0.1823 0.5211
Trypanosoma cruzi squalene synthase, putative 0.2848 0.2647 0.7554
Mycobacterium tuberculosis Putative ferredoxin reductase 0.45 0.4202 0.8989
Schistosoma mansoni lamin 0.0118 0.0076 0.0076
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 2, putative 0.1014 0.092 0.256
Onchocerca volvulus 0.0137 0.0094 0.1106
Plasmodium falciparum V-type K+-independent H+-translocating inorganic pyrophosphatase 0.1014 0.092 0.2631
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0038 0.0109
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.1058 0.0961 0.2056
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0181 0.0136 0.039
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0038 0.0109
Loa Loa (eye worm) polyprenyl synthetase 0.3753 0.3498 1
Onchocerca volvulus 0.0218 0.0171 0.2003
Brugia malayi Calcitonin receptor-like protein seb-1 0.034 0.0286 0.0817
Plasmodium vivax hexokinase, putative 0.0218 0.0171 0.0488
Brugia malayi beta-lactamase family protein 0.0077 0.0038 0.0109
Onchocerca volvulus 0.0077 0.0038 0.0446
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0181 0.0136 0.0297
Leishmania major vacuolar-type proton translocating pyrophosphatase 1, putative 0.1014 0.092 0.2604
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0181 0.0136 0.0265
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.3753 0.3498 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0038 0.0109
Onchocerca volvulus 0.005 0.0013 0.0149
Echinococcus multilocularis glutamate synthase 0.0181 0.0136 0.0136
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0491 0.0428 0.0914
Echinococcus granulosus thioredoxin glutathione reductase 0.1987 0.1836 0.1836
Mycobacterium tuberculosis Probable dehydrogenase 0.45 0.4202 0.8989
Schistosoma mansoni glutamate synthase 0.0181 0.0136 0.0136
Brugia malayi Hexokinase family protein 0.0218 0.0171 0.0488
Schistosoma mansoni hypothetical protein 0.0108 0.0067 0.0067
Plasmodium falciparum V-type H(+)-translocating pyrophosphatase, putative 0.1014 0.092 0.2631
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0038 0.008
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0181 0.0136 0.039
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0013 0.0034
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0181 0.0136 0.1419
Loa Loa (eye worm) hypothetical protein 0.0069 0.0031 0.0088
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0684 0.0609 0.1741
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0083 0.0238
Schistosoma mansoni farnesyl pyrophosphate synthase 0.3753 0.3498 0.3498
Mycobacterium ulcerans ferredoxin reductase 0.0181 0.0136 0.0388
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0181 0.0136 0.039
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0038 0.0055
Echinococcus multilocularis lamin 0.0118 0.0076 0.0076
Loa Loa (eye worm) MH1 domain-containing protein 0.0044 0.0007 0.002
Giardia lamblia NADH oxidase lateral transfer candidate 0.0684 0.0609 0.1406
Echinococcus multilocularis chromobox protein 1 0.0223 0.0175 0.0175
Entamoeba histolytica hexokinase 2 0.0218 0.0171 0.1776
Leishmania major hexokinase, putative 0.0218 0.0171 0.0453
Schistosoma mansoni intermediate filament proteins 0.0118 0.0076 0.0076
Brugia malayi MH2 domain containing protein 0.0645 0.0573 0.1637
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0181 0.0136 0.039
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0181 0.0136 0.0388
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0181 0.0136 0.039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0684 0.0609 0.1697
Schistosoma mansoni hypothetical protein 0.0108 0.0067 0.0067
Trichomonas vaginalis chromobox protein, putative 0.0223 0.0175 0.0502
Echinococcus multilocularis mothers against decapentaplegic 5 0.0044 0.0007 0.0007
Trypanosoma brucei Pyrophosphate-energized vacuolar membrane proton pump 1 0.1014 0.092 0.256
Echinococcus multilocularis GPCR, family 2 0.0108 0.0067 0.0067
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0181 0.0136 0.0388
Schistosoma mansoni hypothetical protein 0.0108 0.0067 0.0067
Schistosoma mansoni lamin 0.0118 0.0076 0.0076
Mycobacterium ulcerans beta-lactamase 0.0077 0.0038 0.0106
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0684 0.0609 0.1302
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0038 0.0038
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0181 0.0136 0.0388
Loa Loa (eye worm) glutaminase 2 0.1563 0.1437 0.4107
Loa Loa (eye worm) hypothetical protein 0.0077 0.0038 0.0109
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0684 0.0609 0.0609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0013 0.0025
Brugia malayi Latrophilin receptor protein 2 0.0108 0.0067 0.0191
Trypanosoma brucei NADH dehydrogenase 0.0181 0.0136 0.0297
Onchocerca volvulus 0.0218 0.0171 0.2003
Echinococcus granulosus hexokinase 0.0218 0.0171 0.0171
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0181 0.0136 0.0388
Schistosoma mansoni smad 0.0044 0.0007 0.0007
Schistosoma mansoni microtubule-associated protein tau 1.066 1 1
Leishmania major hypothetical protein, conserved 0.0077 0.0038 0.0073
Trichomonas vaginalis chromobox protein, putative 0.0134 0.0092 0.0264
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.3753 0.3498 1
Trypanosoma cruzi phytoene synthase, putative 0.0942 0.0853 0.2396
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0038 0.008
Trichomonas vaginalis glutamate synthase, putative 0.0181 0.0136 0.039
Leishmania major hypothetical protein, conserved 0.0181 0.0136 0.0355
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0013 0.0034
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.1058 0.0961 0.2679
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0181 0.0136 0.0297
Schistosoma mansoni chromobox protein 0.0223 0.0175 0.0175
Trypanosoma cruzi polyprenyl synthase, putative 0.1515 0.1392 0.3946
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0181 0.0136 0.0388
Onchocerca volvulus 0.0218 0.0171 0.2003
Echinococcus granulosus lamin dm0 0.0118 0.0076 0.0076
Brugia malayi Hexokinase family protein 0.0067 0.0029 0.0083
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0181 0.0136 0.0136
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.3753 0.3498 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.0076 0.0219
Echinococcus granulosus lamin 0.0118 0.0076 0.0076
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0181 0.0136 0.0136
Toxoplasma gondii V-type H(+)-translocating pyrophosphatase VP1 0.1014 0.092 0.2631
Loa Loa (eye worm) hypothetical protein 0.0942 0.0853 0.2437
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0038 0.0109
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0038 0.0109
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.3753 0.3498 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0181 0.0136 0.039
Brugia malayi hexokinase 0.0218 0.0171 0.0488
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0181 0.0136 0.1419
Onchocerca volvulus 0.0077 0.0038 0.0446
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.1058 0.0961 1
Echinococcus multilocularis Smad4 0.0044 0.0007 0.0007
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0942 0.0853 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0181 0.0136 0.039
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0181 0.0136 0.029
Echinococcus granulosus tumor protein p63 0.1549 0.1424 0.1424
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0181 0.0136 0.039
Plasmodium vivax thioredoxin reductase, putative 0.1973 0.1823 0.5211
Onchocerca volvulus 0.0118 0.0076 0.0896
Echinococcus multilocularis hexokinase 0.0218 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0037 0.0001 0.0002
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0181 0.0136 0.039
Trypanosoma brucei hexokinase 0.0218 0.0171 0.0396
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0181 0.0136 0.039
Leishmania major NADH dehydrogenase, putative 0.0181 0.0136 0.0355
Brugia malayi AMP-binding enzyme family protein 0.005 0.0013 0.0036
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.1058 0.0961 0.0961
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0684 0.0609 0.1739
Echinococcus granulosus GPCR family 2 0.0108 0.0067 0.0067
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0684 0.0609 0.5729
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.1058 0.0961 0.2709
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.0136 0.0338
Trypanosoma brucei squalene synthase, putative 0.2848 0.2647 0.7544
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0033 0.0042
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0181 0.0136 0.0388
Brugia malayi beta-lactamase family protein 0.0077 0.0038 0.0109
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0181 0.0136 0.0338
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0038 0.0106
Entamoeba histolytica hexokinase 1 0.0218 0.0171 0.1776
Trypanosoma brucei hexokinase, putative 0.0218 0.0171 0.0396
Toxoplasma gondii selenide, water dikinase 0.0181 0.0136 0.039
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.3753 0.3498 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0181 0.0136 0.039
Leishmania major cathepsin L-like protease 0.0072 0.0033 0.0059
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.5002 0.4674 1
Loa Loa (eye worm) hexokinase 0.0137 0.0094 0.027
Loa Loa (eye worm) beta-lactamase 0.0077 0.0038 0.0109
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0181 0.0136 0.039
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0013 0.0034
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0013 0.0034
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.1058 0.0961 0.2035
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0013 0.0034
Brugia malayi MH1 domain containing protein 0.0044 0.0007 0.002
Brugia malayi MH2 domain containing protein 0.0044 0.0007 0.002
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0684 0.0609 0.1741
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.3753 0.3498 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0038 0.0109
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.1058 0.0961 0.0961
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.1058 0.0961 0.2056
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.1058 0.0961 0.2749
Echinococcus multilocularis musashi 0.0118 0.0076 0.0076
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0181 0.0136 0.029
Trypanosoma cruzi squalene synthase, putative 0.2848 0.2647 0.7554
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0028 0.0025
Loa Loa (eye worm) intermediate filament protein 0.0118 0.0076 0.0219
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0181 0.0136 0.039
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0108 0.0067 0.0067
Loa Loa (eye worm) glutaminase 0.1563 0.1437 0.4107
Trichomonas vaginalis glutathione reductase, putative 0.0684 0.0609 0.1741
Loa Loa (eye worm) thioredoxin reductase 0.1973 0.1823 0.5211
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0181 0.0136 0.0136
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.45 0.4202 0.8989
Echinococcus multilocularis hexokinase 0.0218 0.0171 0.0171
Onchocerca volvulus 0.0077 0.0038 0.0446
Loa Loa (eye worm) hypothetical protein 0.0057 0.0019 0.0055
Brugia malayi glutathione reductase 0.1973 0.1823 0.5211
Trypanosoma cruzi polyprenyl synthase, putative 0.1515 0.1392 0.3946
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0684 0.0609 0.1741
Loa Loa (eye worm) hypothetical protein 0.0149 0.0106 0.0302
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.1058 0.0961 0.0961
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0684 0.0609 0.1697
Echinococcus multilocularis hexokinase 0.0218 0.0171 0.0171
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0181 0.0136 0.039
Loa Loa (eye worm) hypothetical protein 0.0037 0.0001 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0684 0.0609 0.1662
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.0136 0.0338
Trichomonas vaginalis apoptosis inducing factor, putative 0.0181 0.0136 0.039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0038 0.0038
Mycobacterium leprae Probable lipase LipE 0.0077 0.0038 0.0054
Trichomonas vaginalis glutaminase, putative 0.1563 0.1437 0.4107
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0181 0.0136 0.029
Trypanosoma cruzi trypanothione reductase, putative 0.1973 0.1823 0.5185
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0181 0.0136 0.0136
Plasmodium vivax vacuolar-type H+ pumping pyrophosphatase, putative 0.1014 0.092 0.2631
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0684 0.0609 0.0609
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0684 0.0609 0.1739
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0181 0.0136 0.1419
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.034 0.0286 0.0817
Trypanosoma brucei trypanothione reductase 0.1973 0.1823 0.5164
Loa Loa (eye worm) hypothetical protein 0.0055 0.0017 0.0049
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0181 0.0136 0.0338
Brugia malayi Thioredoxin reductase 0.1973 0.1823 0.5211
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.1058 0.0961 1
Trypanosoma cruzi solanesyl-diphosphate synthase 0.1058 0.0961 0.2709
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0684 0.0609 0.1697
Schistosoma mansoni glutathione synthetase 0.1058 0.0961 0.0961
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0502 0.0438 0.1253
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.3753 0.3498 1
Onchocerca volvulus 0.0234 0.0186 0.2185
Loa Loa (eye worm) hypothetical protein 0.005 0.0013 0.0036
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0684 0.0609 0.1662
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0181 0.0136 0.0136
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.1058 0.0961 0.2056
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0181 0.0136 0.0265
Schistosoma mansoni smad1 5 8 and 0.0044 0.0007 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0044 0.0007 0.002
Leishmania major cathepsin L-like protease 0.0072 0.0033 0.0059
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0038 0.0109
Leishmania major cathepsin L-like protease 0.0072 0.0033 0.0059
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.1515 0.1392 0.3978
Brugia malayi glutaminase DH11.1 0.1563 0.1437 0.4107
Schistosoma mansoni glutamate synthase 0.0181 0.0136 0.0136
Trypanosoma cruzi trypanothione reductase, putative 0.0684 0.0609 0.1697
Schistosoma mansoni hypothetical protein 0.0942 0.0853 0.0853
Onchocerca volvulus 0.0118 0.0076 0.0896
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0181 0.0136 0.039
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0684 0.0609 0.1741
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0181 0.0136 0.039
Brugia malayi MH2 domain containing protein 0.0044 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0125 0.0083 0.0238
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0181 0.0136 0.0136
Mycobacterium tuberculosis Conserved protein 0.0077 0.0038 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0083 0.0238
Loa Loa (eye worm) hypothetical protein 0.0077 0.0038 0.0109
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0108 0.0067 0.0191
Mycobacterium ulcerans hypothetical protein 0.0077 0.0038 0.0106
Trichomonas vaginalis mercuric reductase, putative 0.0684 0.0609 0.1741
Trypanosoma cruzi Vacuolar proton pyrophosphatase 1, putative 0.1014 0.092 0.2591
Plasmodium falciparum thioredoxin reductase 0.1973 0.1823 0.5211
Plasmodium vivax ferrodoxin reductase, putative 0.0181 0.0136 0.039
Mycobacterium ulcerans glutamate synthase subunit beta 0.0181 0.0136 0.0388
Plasmodium falciparum ferrodoxin reductase-like protein 0.0181 0.0136 0.039
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0181 0.0136 0.0265
Loa Loa (eye worm) hypothetical protein 0.0232 0.0184 0.0527
Loa Loa (eye worm) hypothetical protein 0.0108 0.0067 0.0191
Leishmania major solanesyl-diphosphate synthase, putative 0.1058 0.0961 0.2722
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0181 0.0136 0.039
Entamoeba histolytica disulphide oxidoreductase, putative 0.0181 0.0136 0.1419
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0033 0.0042
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0038 0.008
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.1058 0.0961 1
Echinococcus multilocularis lamin dm0 0.0118 0.0076 0.0076
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0108 0.0067 0.0067
Loa Loa (eye worm) hexokinase 0.0218 0.0171 0.0488
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.1239 0.1132 0.242
Mycobacterium ulcerans monoxygenase 0.0181 0.0136 0.0388
Toxoplasma gondii ABC1 family protein 0.0077 0.0038 0.0109
Brugia malayi Polyprenyl synthetase family protein 0.3753 0.3498 1
Echinococcus granulosus hexokinase 0.0218 0.0171 0.0171
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0684 0.0609 0.1697
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.3753 0.3498 1
Schistosoma mansoni hypothetical protein 0.0108 0.0067 0.0067
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0684 0.0609 0.1697
Treponema pallidum NADH oxidase 0.0684 0.0609 0.3766
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0684 0.0609 0.1662
Schistosoma mansoni smad1 5 8 and 0.0044 0.0007 0.0007
Echinococcus granulosus glutamate synthase 0.0181 0.0136 0.0136
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0013 0.0132
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0181 0.0136 0.0136
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0038 0.008
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0181 0.0136 0.1419
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0134 0.0092 0.1081
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.3753 0.3498 0.7483
Loa Loa (eye worm) latrophilin receptor protein 2 0.0108 0.0067 0.0191
Echinococcus multilocularis Chromobox protein 3 0.0036 0.0000000011648 0.0000000011648
Plasmodium vivax V-type H(+)-translocating pyrophosphatase, putative 0.1014 0.092 0.2631
Mycobacterium ulcerans dehydrogenase 0.0181 0.0136 0.0388
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0038 0.0038
Echinococcus granulosus chromobox protein 1 0.0223 0.0175 0.0175
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0181 0.0136 0.039
Loa Loa (eye worm) transcription factor SMAD2 0.0645 0.0573 0.1637
Mycobacterium ulcerans NADH dehydrogenase 0.0181 0.0136 0.0388
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.3753 0.3498 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0013 0.0036
Brugia malayi Hexokinase family protein 0.0137 0.0094 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0049 0.014
Schistosoma mansoni hypothetical protein 0.0232 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.034 0.0286 0.0817
Plasmodium falciparum glutathione reductase 0.0684 0.0609 0.1741
Echinococcus granulosus smad 0.0044 0.0007 0.0007
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0038 0.008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0108 0.0067 0.0067
Echinococcus multilocularis thioredoxin glutathione reductase 0.1987 0.1836 0.1836
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0684 0.0609 0.1697
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0684 0.0609 0.1697
Loa Loa (eye worm) Smad1 0.0044 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0116 0.0074 0.0213
Mycobacterium ulcerans phytoene synthase, CrtB 0.1239 0.1132 0.3233
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0181 0.0136 0.0338
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.1058 0.0961 1
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.1058 0.0961 0.0961
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.45 0.4202 0.8989
Loa Loa (eye worm) hexokinase 0.0067 0.0029 0.0083
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.1515 0.1392 0.1392
Brugia malayi SET domain containing protein 0.0038 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0001 0.0002
Schistosoma mansoni sulfide quinone reductase 0.0181 0.0136 0.0136
Onchocerca volvulus Hexokinase homolog 0.0137 0.0094 0.1106
Brugia malayi Heterochromatin protein 1 0.0223 0.0175 0.0502
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0684 0.0609 0.1662
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0038 0.0109
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0038 0.0038
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0013 0.0132
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.1058 0.0961 0.2749
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.3753 0.3498 1
Trypanosoma brucei farnesyl pyrophosphate synthase 0.3753 0.3498 1
Trypanosoma cruzi vacuolar-type proton translocating pyrophosphatase 1 0.1014 0.092 0.2591
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0181 0.0136 0.0297
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.016 0.0456
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0684 0.0609 0.1711
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0181 0.0136 0.029
Echinococcus multilocularis chromobox protein 1 0.0223 0.0175 0.0175
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0684 0.0609 0.1711

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 4 % Percent inhibition of carrageenan paw edema in rat, administered orally at a dose of one tenth of oral lethal dose in mice ChEMBL. 6965727
Inhibition (binding) = 7 % Inhibition of prostaglandin synthetase in bovine seminal vesicle microsomes using Beckman liquid scintillation counter at 10 e-5 M ChEMBL. 6965727
Inhibition (binding) = 7 % Inhibition of prostaglandin synthetase in bovine seminal vesicle microsomes using Beckman liquid scintillation counter at 10 e-5 M ChEMBL. 6965727
LD50 (ADMET) > 1000 mg kg-1 Lethal dose in mice determined by Litchfield and Wilcoxon methods after peroral administration. ChEMBL. 6965727
LD50 (ADMET) > 1000 mg kg-1 Lethal dose in mice determined by Litchfield and Wilcoxon methods after peroral administration. ChEMBL. 6965727

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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