Detailed information for compound 906218

Basic information

Technical information
  • TDR Targets ID: 906218
  • Name: N-[2-(1,3-benzodioxol-5-yl)-2-[4-(2-fluorophe nyl)piperazin-1-yl]ethyl]acetamide
  • MW: 385.432 | Formula: C21H24FN3O3
  • H donors: 1 H acceptors: 1 LogP: 2.61 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)NCC(c1ccc2c(c1)OCO2)N1CCN(CC1)c1ccccc1F
  • InChi: 1S/C21H24FN3O3/c1-15(26)23-13-19(16-6-7-20-21(12-16)28-14-27-20)25-10-8-24(9-11-25)18-5-3-2-4-17(18)22/h2-7,12,19H,8-11,13-14H2,1H3,(H,23,26)
  • InChiKey: ZHOUVHOAMFMHNA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(1,3-benzodioxol-5-yl)-2-[4-(2-fluorophenyl)-1-piperazinyl]ethyl]acetamide
  • N-[2-(1,3-benzodioxol-5-yl)-2-[4-(2-fluorophenyl)piperazin-1-yl]ethyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0357 0.0354
Giardia lamblia Cathepsin L precursor 0.0055 0.032 0.0167
Onchocerca volvulus 0.0105 0.0759 0.0733
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.032 0.0236
Entamoeba histolytica cysteine proteinase 1, putative 0.0105 0.0762 0.076
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0107 0.0021
Echinococcus multilocularis insulin receptor 0.0168 0.1317 0.1315
Echinococcus granulosus cGMP dependent protein kinase 1 0.0036 0.0147 0.0144
Giardia lamblia Cathepsin L precursor 0.0055 0.032 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0333 0.2791 0.2728
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0055 0.032 0.0298
Echinococcus multilocularis epidermal growth factor receptor 0.0238 0.1945 0.1943
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.006 0.0357 0.0354
Echinococcus multilocularis protein kinase c eta type 0.0105 0.0759 0.0756
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0162 0.1264 0.1262
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0107 0.0104
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0629 0.5431 0.5431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.1412 0.1337
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0055 0.032 0.0298
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0162 0.1264 0.1262
Schistosoma mansoni unc-13 (munc13) 0.0124 0.0927 0.0925
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0055 0.032 0.0317
Trypanosoma cruzi cdc2-related kinase 1 0.006 0.0357 0.0354
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0789 0.0786
Brugia malayi Protein kinase domain containing protein 0.0162 0.1264 0.1245
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0953 0.831 0.8309
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0155 0.007
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0055 0.032 0.0298
Echinococcus granulosus epidermal growth factor receptor 0.0151 0.1169 0.1166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.1412 0.1337
Giardia lamblia Kinase, CMGC CK2 0.0152 0.1175 0.1036
Entamoeba histolytica cysteine protease, putative 0.0105 0.0762 0.076
Trypanosoma brucei Casein kinase II 0.0152 0.1175 0.1173
Brugia malayi Cathepsin L-like precursor 0.0178 0.1412 0.1392
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0124 0.0927 0.0925
Leishmania major cathepsin L-like protease 0.0178 0.1412 0.1409
Echinococcus granulosus cathepsin L 0.0055 0.032 0.0317
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0068 0.0427 0.0425
Loa Loa (eye worm) AGC/PKN protein kinase 0.0162 0.1264 0.1264
Schistosoma mansoni titin 0.0023 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0105 0.0759 0.0759
Brugia malayi Cathepsin L-like precursor 0.0128 0.0969 0.0949
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0162 0.1264 0.1264
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0036 0.0147 0.0144
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.1412 0.1337
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0107 0.0104
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.003 0.0094 0.0091
Loa Loa (eye worm) hypothetical protein 0.0699 0.6048 0.6048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.032 0.0236
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0333 0.2791 0.2789
Brugia malayi cathepsin F-like cysteine proteinase 0.005 0.0268 0.0246
Echinococcus granulosus hyperpolarization activated cyclic 0.0029 0.0086 0.0084
Plasmodium vivax vivapain-2 0.0178 0.1412 0.1392
Trichomonas vaginalis AGC family protein kinase 0.0162 0.1264 0.1188
Trypanosoma cruzi cdc2-related kinase 1 0.006 0.0357 0.0354
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0074 0.0488 0.0486
Onchocerca volvulus 0.0178 0.1412 0.1388
Entamoeba histolytica protein kinase, putative 0.0162 0.1264 0.1262
Loa Loa (eye worm) hypothetical protein 0.005 0.0268 0.0268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.1412 0.1337
Loa Loa (eye worm) hypothetical protein 0.0055 0.032 0.032
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0055 0.032 0.0317
Toxoplasma gondii cathepsin B 0.0333 0.2791 0.2789
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0068 0.0427 0.0425
Echinococcus granulosus myotubularin protein 13 0.0105 0.0759 0.0756
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0105 0.0762 0.076
Trichomonas vaginalis AGC family protein kinase 0.0162 0.1264 0.1188
Echinococcus granulosus cyclin dependent kinase 1 0.006 0.0357 0.0354
Schistosoma mansoni voltage-gated potassium channel 0.0162 0.1264 0.1262
Toxoplasma gondii ck2 beta subunit 0.0037 0.0155 0.0153
Brugia malayi Cathepsin L-like precursor 0.0178 0.1412 0.1392
Plasmodium falciparum serine repeat antigen 9 0.0055 0.032 0.0317
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0055 0.032 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.1412 0.1337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0183 0.018
Loa Loa (eye worm) hypothetical protein 0.0105 0.0759 0.0759
Echinococcus multilocularis voltage gated potassium channel 0.0043 0.0207 0.0205
Echinococcus multilocularis cyclin dependent kinase 0.006 0.0357 0.0354
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0055 0.032 0.0298
Onchocerca volvulus 0.0178 0.1412 0.1388
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0029 0.0086 0.0084
Leishmania major cathepsin L-like protease 0.0178 0.1412 0.1409
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.0709 0.0706
Giardia lamblia Cysteine protease 0.0055 0.032 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.0969 0.0891
Loa Loa (eye worm) hypothetical protein 0.0128 0.0969 0.0969
Entamoeba histolytica cysteine protease, putative 0.0178 0.1412 0.1409
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.0762 0.0682
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0055 0.032 0.0317
Echinococcus granulosus roundabout 2 0.0022 0.0026 0.0023
Brugia malayi cathepsin Z-like cysteine proteinase 0.0055 0.032 0.0298
Trypanosoma cruzi cysteine peptidase, putative 0.0178 0.1412 0.1409
Echinococcus granulosus protein kinase shaggy 0.1142 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0034 0.0032
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0055 0.032 0.0298
Schistosoma mansoni serine/threonine protein kinase 0.0285 0.2366 0.2364
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.1412 0.1337
Brugia malayi Pleckstrin Homology Domain 0.0105 0.0759 0.0738
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0162 0.1264 0.1262
Schistosoma mansoni serine/threonine protein kinase 0.0879 0.7655 0.7655
Onchocerca volvulus 0.0124 0.0927 0.0902
Toxoplasma gondii cathepsin CPC1 0.0055 0.032 0.0317
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1142 1 1
Echinococcus granulosus mitogen activated protein kinase 0.0068 0.0427 0.0425
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0709 0.0706
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0178 0.1412 0.1409
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0068 0.0427 0.0425
Echinococcus granulosus protein kinase c iota type 0.035 0.294 0.2938
Loa Loa (eye worm) hypothetical protein 0.0139 0.1068 0.1068
Echinococcus granulosus protein kinase c epsilon type 0.0285 0.2366 0.2364
Schistosoma mansoni tyrosine kinase 0.0168 0.1317 0.1315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.1412 0.1337
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.032 0.0236
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0162 0.1264 0.1264
Loa Loa (eye worm) fibroinase 0.0178 0.1412 0.1412
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0055 0.032 0.0236
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0333 0.2791 0.2789
Schistosoma mansoni 60S ribosomal protein L21 0.0023 0.0033 0.0031
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0178 0.1412 0.1412
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0155 0.0153
Trichomonas vaginalis CMGC family protein kinase 0.1142 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.1412 0.1337
Trichomonas vaginalis AGC family protein kinase 0.0162 0.1264 0.1188
Plasmodium falciparum casein kinase 2, alpha subunit 0.0152 0.1175 0.1173
Schistosoma mansoni tyrosine kinase 0.0238 0.1945 0.1943
Loa Loa (eye worm) hypothetical protein 0.0039 0.0175 0.0175
Brugia malayi RhoGEF domain containing protein 0.0105 0.0759 0.0738
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0033 0.0031
Brugia malayi C1-like domain containing protein 0.0121 0.0906 0.0886
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0155 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0152 0.1175 0.1098
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0036 0.0147 0.0144
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0105 0.0759 0.0756
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0107 0.0085
Giardia lamblia Kinase, CMGC CDK 0.006 0.0357 0.0205
Loa Loa (eye worm) hypothetical protein 0.0055 0.032 0.032
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0107 0.0104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0178 0.1412 0.1409
Echinococcus granulosus titin 0.0023 0.0034 0.0032
Echinococcus granulosus voltage gated potassium channel 0.0043 0.0207 0.0205
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0178 0.1412 0.1337
Onchocerca volvulus 0.0178 0.1412 0.1388
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0029 0.0086 0.0084
Echinococcus granulosus raf serine:threonine protein kinase 0.0108 0.0789 0.0786
Loa Loa (eye worm) Csnk2b protein 0.0037 0.0155 0.0155
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0162 0.1264 0.1262
Plasmodium falciparum glycogen synthase kinase 3 0.1142 1 1
Echinococcus multilocularis mitogen activated protein kinase 0.0068 0.0427 0.0425
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.0023 0.002
Brugia malayi p70 ribosomal S6 kinase beta 0.0162 0.1264 0.1245
Trichomonas vaginalis CMGC family protein kinase 0.0152 0.1175 0.1098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.1412 0.1337
Echinococcus multilocularis cathepsin L cysteine protease 0.0178 0.1412 0.1409
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0009 0.0006
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0029 0.0086 0.0084
Brugia malayi Csnk2b protein 0.0037 0.0155 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0055 0.032 0.0236
Entamoeba histolytica cysteine protease, putative 0.0055 0.032 0.0317
Trypanosoma cruzi cysteine peptidase, putative 0.0178 0.1412 0.1409
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0155 0.0153
Echinococcus granulosus NDR protein kinase 0.0162 0.1264 0.1262
Onchocerca volvulus 0.0055 0.032 0.0293
Entamoeba histolytica cysteine protease, putative 0.0055 0.032 0.0317
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.0762 0.076
Schistosoma mansoni cathepsin F (C01 family) 0.0178 0.1412 0.1409
Giardia lamblia Cathepsin B precursor 0.0333 0.2791 0.2677
Brugia malayi Papain family cysteine protease containing protein 0.0105 0.0762 0.0742
Giardia lamblia Cathepsin B precursor 0.0055 0.032 0.0167
Brugia malayi cell division control protein 2 homolog 0.006 0.0357 0.0335
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.006 0.0357 0.0357
Echinococcus multilocularis cyclin dependent kinase 5 0.006 0.0357 0.0354
Echinococcus granulosus cathepsin l cysteine peptidase 0.0178 0.1412 0.1409
Trichomonas vaginalis CMGC family protein kinase 0.0152 0.1175 0.1098
Brugia malayi Cyclic-nucleotide gated cation channel 0.0029 0.0086 0.0064
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0151 0.1169 0.1166
Trypanosoma cruzi cruzipain precursor, putative 0.005 0.0268 0.0266
Echinococcus multilocularis cathepsin b 0.0953 0.831 0.8309
Plasmodium vivax serine-repeat antigen (SERA) 0.0055 0.032 0.0298
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0301 0.2506 0.2506
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0178 0.1412 0.1409
Echinococcus multilocularis serine:threonine protein kinase N2 0.0162 0.1264 0.1262
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0183 0.018
Loa Loa (eye worm) hypothetical protein 0.0055 0.032 0.032
Echinococcus multilocularis hyperpolarization activated cyclic 0.0029 0.0086 0.0084
Loa Loa (eye worm) hypothetical protein 0.0055 0.032 0.032
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0268 0.0266
Echinococcus granulosus cathepsin L cysteine protease 0.0105 0.0762 0.076
Brugia malayi Cathepsin L-like precursor 0.0178 0.1412 0.1392
Onchocerca volvulus Cathepsin F homolog 0.0178 0.1412 0.1388
Entamoeba histolytica cysteine proteinase, putative 0.0128 0.0969 0.0967
Entamoeba histolytica cysteine protease, putative 0.0055 0.032 0.0317
Giardia lamblia Cathepsin B precursor 0.0333 0.2791 0.2677
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.032 0.0317
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1142 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.032 0.0317
Echinococcus granulosus casein kinase ii subunit alpha 0.0152 0.1175 0.1173
Loa Loa (eye worm) hypothetical protein 0.0055 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0105 0.0759 0.0759
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0029 0.0086 0.0084
Loa Loa (eye worm) hypothetical protein 0.0043 0.021 0.021
Entamoeba histolytica protein kinase, putative 0.0035 0.0141 0.0139
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0175 0.0153
Leishmania major cathepsin L-like protease 0.0178 0.1412 0.1409
Trypanosoma brucei rac serine-threonine kinase, putative 0.0162 0.1264 0.1262
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0333 0.2791 0.2789
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.1264 0.1262
Plasmodium vivax unspecified product 0.0105 0.0762 0.0742
Entamoeba histolytica cysteine protease, putative 0.0105 0.0762 0.076
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0148 0.1143 0.1141
Toxoplasma gondii cathepsin CPC2 0.0055 0.032 0.0317
Schistosoma mansoni vav2 0.0105 0.0759 0.0756
Entamoeba histolytica cell division protein kinase 2, putative 0.006 0.0357 0.0354
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.032 0.0317
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0183 0.018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.1412 0.1337
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0427 0.0344
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0953 0.831 0.8309
Echinococcus granulosus cGMP dependent protein kinase 1 0.0036 0.0147 0.0144
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0086
Echinococcus granulosus epidermal growth factor receptor 0.0238 0.1945 0.1943
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0121 0.0906 0.0886
Trypanosoma brucei cysteine peptidase C (CPC) 0.0333 0.2791 0.2789
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0175 0.0173
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.0709 0.0688
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0357 0.0273
Entamoeba histolytica protein kinase, putative 0.0162 0.1264 0.1262
Echinococcus granulosus cyclin dependent kinase 0.006 0.0357 0.0354
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0107 0.0104
Leishmania major cathepsin L-like protease 0.0178 0.1412 0.1409
Brugia malayi cathepsin B-like cysteine proteinase 0.0953 0.831 0.8306
Loa Loa (eye worm) hypothetical protein 0.0953 0.831 0.831
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.0762 0.0682
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0709 0.0628
Echinococcus multilocularis casein kinase ii subunit alpha 0.0152 0.1175 0.1173
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0155 0.007
Echinococcus multilocularis serine:threonine protein kinase N2 0.0162 0.1264 0.1262
Leishmania major cathepsin L-like protease 0.0178 0.1412 0.1409
Entamoeba histolytica cysteine proteinase, putative 0.0178 0.1412 0.1409
Schistosoma mansoni hypothetical protein 0.0105 0.0759 0.0756
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0107 0.0104
Entamoeba histolytica cell division protein kinase 2, putative 0.006 0.0357 0.0354
Brugia malayi protein kinase C II. 0.0285 0.2366 0.2349
Loa Loa (eye worm) AGC/NDR protein kinase 0.0162 0.1264 0.1264
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0155 0.007
Loa Loa (eye worm) hypothetical protein 0.0178 0.1412 0.1412
Schistosoma mansoni diacylglycerol kinase theta 0.0105 0.0759 0.0756
Schistosoma mansoni cathepsin S (C01 family) 0.0055 0.032 0.0317
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0155 0.0153
Echinococcus multilocularis cathepsin L 0.0105 0.0762 0.076
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.004 0.0183 0.0183
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0427 0.0344
Schistosoma mansoni tyrosine kinase 0.0147 0.1139 0.1136
Toxoplasma gondii cathepsin CPL 0.0178 0.1412 0.1409
Echinococcus granulosus mitogen activated protein kinase 3 0.0068 0.0427 0.0425
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.1412 0.1337
Echinococcus granulosus insulin growth factor 1 receptor beta 0.017 0.1343 0.1341
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.032 0.032
Plasmodium falciparum serine repeat antigen 5 0.0055 0.032 0.0317
Echinococcus granulosus protein kinase C gamma type 0.0774 0.6722 0.6721
Brugia malayi Cathepsin L-like precursor 0.0128 0.0969 0.0949
Trypanosoma cruzi cdc2-related kinase 3 0.006 0.0357 0.0354
Echinococcus multilocularis titin 0.0023 0.0034 0.0032
Entamoeba histolytica cysteine protease, putative 0.0105 0.0762 0.076
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.0023 0.002
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1142 1 1
Toxoplasma gondii AGC kinase 0.0162 0.1264 0.1262
Leishmania major cathepsin L-like protease 0.0178 0.1412 0.1409
Echinococcus granulosus cathepsin b 0.0953 0.831 0.8309
Brugia malayi Egg laying defective protein 4 0.0036 0.0147 0.0125
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.006 0.0357 0.0357
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0162 0.1264 0.1262
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0178 0.1412 0.1409
Schistosoma mansoni tyrosine kinase 0.0147 0.1139 0.1136
Giardia lamblia Kinase, CMGC MAPK 0.0068 0.0427 0.0276
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0107 0.0107
Echinococcus granulosus cGMP dependent protein kinase 0.0036 0.0147 0.0144
Trypanosoma cruzi cysteine proteinase, putative 0.0105 0.0762 0.076
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1142 1 1
Entamoeba histolytica cysteine protease, putative 0.0055 0.032 0.0317
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.032 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0128 0.0969 0.0891
Echinococcus multilocularis serine threonine protein kinase 0.0774 0.6722 0.6721
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0155 0.007
Trichomonas vaginalis AGC family protein kinase 0.0162 0.1264 0.1188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0178 0.1412 0.1409
Giardia lamblia Kinase, CMGC GSK 0.1142 1 1
Echinococcus multilocularis cyclin dependent kinase 1 0.006 0.0357 0.0354
Entamoeba histolytica cysteine protease, putative 0.0105 0.0762 0.076
Brugia malayi diacylglycerol kinase 0.0105 0.0759 0.0738
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0709 0.0628
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0107 0.0085
Echinococcus multilocularis cathepsin b 0.0953 0.831 0.8309
Giardia lamblia Cathepsin L precursor 0.0055 0.032 0.0167
Loa Loa (eye worm) cathepsin B 0.0333 0.2791 0.2791
Loa Loa (eye worm) hypothetical protein 0.0105 0.0759 0.0759
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0121 0.0906 0.0904
Brugia malayi Ras association domain family 1 isoform A 0.0105 0.0759 0.0738
Giardia lamblia Kinase, PLK 0.0099 0.0709 0.0562
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0142 0.1094 0.1091
Entamoeba histolytica cysteine protease, putative 0.0105 0.0762 0.076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0178 0.1412 0.1409
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0155 0.0133
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0068 0.0427 0.0425
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0155 0.007
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0107 0.0107
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0055 0.032 0.0317
Plasmodium vivax vivapain-3 0.0105 0.0762 0.0742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0178 0.1412 0.1409
Brugia malayi Cathepsin L-like precursor 0.0178 0.1412 0.1392
Giardia lamblia Encystation-specific protease 0.0055 0.032 0.0167
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0029 0.0086 0.0084
Echinococcus multilocularis serine:threonine protein kinase 38 0.0162 0.1264 0.1262
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0709 0.0628
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0124 0.0927 0.0925
Leishmania major DNA polymerase eta, putative 0.0028 0.0071 0.0069
Echinococcus multilocularis cathepsin L cysteine protease 0.0178 0.1412 0.1409
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0037 0.0155 0.0153
Echinococcus granulosus calcium activated potassium channel 0.0026 0.006 0.0057
Trichomonas vaginalis AGC family protein kinase 0.0162 0.1264 0.1188
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.032 0.0298
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0427 0.0425
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.032 0.0317
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0427 0.0344
Plasmodium falciparum serine repeat antigen 7 0.0055 0.032 0.0317
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0105 0.0762 0.076
Echinococcus granulosus hyperpolarization activated cyclic 0.0029 0.0086 0.0084
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0162 0.1264 0.1264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.0762 0.076
Giardia lamblia Kinase, CMGC GSK 0.1142 1 1
Echinococcus multilocularis cysteine protease 0.0178 0.1412 0.1409
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0178 0.1412 0.1409
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0027 0.0069 0.0069
Onchocerca volvulus 0.0023 0.0034 0.0007
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0162 0.1264 0.1264
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0211 0.1703 0.1703
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.0709 0.0706
Echinococcus multilocularis 0.0072 0.0468 0.0466
Echinococcus granulosus casein kinase ii subunit beta 0.0037 0.0155 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.1412 0.1337
Loa Loa (eye worm) raf kinase 0.0105 0.0759 0.0759
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0111 0.0812 0.0792
Echinococcus granulosus Rac GTPase activating protein 1 0.0105 0.0759 0.0756
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0037 0.0155 0.0153
Plasmodium falciparum cysteine proteinase falcipain 3 0.0178 0.1412 0.1409
Echinococcus granulosus RNA directed DNA polymerase 0.0594 0.5115 0.5114
Giardia lamblia Cysteine protease 0.0055 0.032 0.0167
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0111 0.0812 0.0812
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.006 0.0357 0.0354
Echinococcus granulosus cathepsin l1 0.0128 0.0969 0.0967
Entamoeba histolytica protein kinase, putative 0.0162 0.1264 0.1262
Echinococcus multilocularis cathepsin L 0.0055 0.032 0.0317
Trichomonas vaginalis AGC family protein kinase 0.0162 0.1264 0.1188
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0183 0.018
Brugia malayi cathepsin F-like cysteine proteinase 0.0055 0.032 0.0298
Schistosoma mansoni protein kinase C mu 0.0105 0.0759 0.0756
Schistosoma mansoni cathepsin C 0.0055 0.032 0.0317
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0148 0.1143 0.1143
Trypanosoma cruzi DNA polymerase eta, putative 0.0028 0.0071 0.0069
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.032 0.0298
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0105 0.0759 0.0759
Plasmodium vivax glycogen synthase kinase 3, putative 0.1142 1 1
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0155 0.0128
Plasmodium vivax vivapain-1 0.0105 0.0762 0.0742
Echinococcus multilocularis calcium activated potassium channel 0.0026 0.006 0.0057
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.032 0.0317
Brugia malayi Protein kinase domain containing protein 0.0023 0.0027 0.0005
Schistosoma mansoni DNA polymerase eta 0.0039 0.0175 0.0173
Echinococcus multilocularis N chimaerin 0.0105 0.0759 0.0756
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.0709 0.0709
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.1412 0.1337
Leishmania major casein kinase II, putative 0.0152 0.1175 0.1173
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0155 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0152 0.1175 0.1098
Giardia lamblia Hypothetical protein 0.0055 0.032 0.0167
Loa Loa (eye worm) hypothetical protein 0.0128 0.0969 0.0969
Loa Loa (eye worm) cysteine protease 0.0178 0.1412 0.1412
Trypanosoma cruzi cysteine peptidase, putative 0.0178 0.1412 0.1409
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0336 0.0252
Schistosoma mansoni serine/threonine protein kinase 0.0879 0.7655 0.7655
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1142 1 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0055 0.032 0.0298
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.006 0.0357 0.0357
Brugia malayi Cathepsin L-like precursor 0.0178 0.1412 0.1392
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0139 0.1068 0.1068
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0107 0.0104
Brugia malayi RhoGAP domain containing protein 0.0105 0.0759 0.0738
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0155 0.007
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0162 0.1264 0.1262
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0709 0.0628
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0178 0.1412 0.1409
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0178 0.1412 0.1409
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0107 0.0104
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0138 0.1056 0.0979
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.1264 0.1262
Entamoeba histolytica cysteine protease, putative 0.0105 0.0762 0.076
Giardia lamblia Cathepsin L-like protease 0.0055 0.032 0.0167
Loa Loa (eye worm) CAMK protein kinase 0.0023 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0055 0.032 0.0317
Brugia malayi cathepsin L-like precursor 0.0128 0.0969 0.0949
Entamoeba histolytica diacylglycerol kinase, putative 0.0105 0.0759 0.0756
Loa Loa (eye worm) TK/EGFR protein kinase 0.0238 0.1945 0.1945
Plasmodium vivax serine-repeat antigen (SERA) 0.0055 0.032 0.0298
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0906 0.0904
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.006 0.0357 0.0354
Leishmania major cysteine peptidase A (CPA) 0.0178 0.1412 0.1409
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0105 0.0762 0.076
Giardia lamblia Cathepsin L-like protease 0.0055 0.032 0.0167
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0285 0.2366 0.2366
Loa Loa (eye worm) ctsf protein 0.0178 0.1412 0.1412
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0029 0.0086 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0183 0.018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.1412 0.1337
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0594 0.5115 0.5114
Brugia malayi protein kinase C3,putative 0.0205 0.1648 0.1629
Loa Loa (eye worm) AGC/PKG protein kinase 0.0036 0.0147 0.0147
Brugia malayi Protein kinase c protein 2 0.0734 0.6364 0.6356
Trichomonas vaginalis AGC family protein kinase 0.0162 0.1264 0.1188
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0142 0.1094 0.1091
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0107 0.0085
Loa Loa (eye worm) hypothetical protein 0.005 0.0268 0.0268
Echinococcus multilocularis expressed conserved protein 0.0036 0.0147 0.0144
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0155 0.007
Brugia malayi cathepsin L precursor 0.0055 0.032 0.0298
Leishmania major cathepsin L-like protease 0.0178 0.1412 0.1409
Onchocerca volvulus 0.0178 0.1412 0.1388
Giardia lamblia Cysteine protease 0.0055 0.032 0.0167
Onchocerca volvulus 0.1142 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0147 0.0144
Echinococcus multilocularis casein kinase ii subunit beta 0.0037 0.0155 0.0153
Brugia malayi Casein kinase II, alpha chain 0.0152 0.1175 0.1155
Echinococcus granulosus cathepsin b 0.0953 0.831 0.8309
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.032 0.0236
Entamoeba histolytica diacylglycerol kinase, putative 0.0105 0.0759 0.0756
Plasmodium falciparum serine repeat antigen 2 0.0055 0.032 0.0317
Entamoeba histolytica protein kinase domain containing protein 0.0152 0.1175 0.1173
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0037 0.0155 0.0153
Trypanosoma brucei protein kinase, putative 0.0068 0.0427 0.0425
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0155 0.007
Brugia malayi Protein kinase domain containing protein 0.0168 0.1317 0.1298
Plasmodium falciparum cGMP-dependent protein kinase 0.0036 0.0147 0.0144
Entamoeba histolytica protein kinase, putative 0.0162 0.1264 0.1262
Loa Loa (eye worm) hypothetical protein 0.005 0.0268 0.0268
Trichomonas vaginalis CMGC family protein kinase 0.1142 1 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0055 0.032 0.0298
Echinococcus granulosus unc 13 munc13 0.0124 0.0927 0.0925
Giardia lamblia Cathepsin B precursor 0.0055 0.032 0.0167
Trypanosoma brucei protein kinase, putative 0.1142 1 1
Entamoeba histolytica cysteine protease, putative 0.0105 0.0762 0.076
Entamoeba histolytica cysteine protease, putative 0.0105 0.0762 0.076
Onchocerca volvulus 0.0178 0.1412 0.1388
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0029 0.0086 0.0084
Schistosoma mansoni protein kinase 0.0142 0.1094 0.1091
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0155 0.007
Toxoplasma gondii preprocathepsin c precursor, putative 0.0055 0.032 0.0317
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0709 0.0706
Schistosoma mansoni tyrosine kinase 0.0151 0.1169 0.1166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0178 0.1412 0.1409
Echinococcus granulosus twitchin 0.0032 0.0113 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0147 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0055 0.032 0.0236
Onchocerca volvulus 0.0178 0.1412 0.1388
Schistosoma mansoni protein kinase C 0.0124 0.0927 0.0925
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0148 0.1143 0.1123
Echinococcus granulosus cathepsin l1 0.0178 0.1412 0.1409
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.032 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.032 0.0236
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0029 0.0086 0.0084
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0879 0.7655 0.7655
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0055 0.032 0.0298
Loa Loa (eye worm) hypothetical protein 0.0128 0.0969 0.0969
Giardia lamblia Cathepsin L precursor 0.0055 0.032 0.0167
Loa Loa (eye worm) hypothetical protein 0.0105 0.0759 0.0759
Toxoplasma gondii CMGC kinase, CK2 family 0.0152 0.1175 0.1173
Loa Loa (eye worm) hypothetical protein 0.0058 0.034 0.034
Brugia malayi protein unc-22 0.0023 0.0034 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.1264 0.1262
Schistosoma mansoni protein kinase 0.0142 0.1094 0.1091
Echinococcus granulosus titin 0.0023 0.0034 0.0032
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.017 0.1343 0.1341
Plasmodium falciparum serine repeat antigen 1 0.0055 0.032 0.0317
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1142 1 1
Echinococcus multilocularis unc 13 (munc13) 0.0124 0.0927 0.0925
Brugia malayi Protein kinase domain containing protein 0.006 0.0357 0.0335
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0152 0.1175 0.1155
Brugia malayi Variant SH3 domain containing protein 0.0105 0.0759 0.0738
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.1412 0.1337
Loa Loa (eye worm) AGC/AKT protein kinase 0.0162 0.1264 0.1264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.1412 0.1337
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0128 0.0969 0.0967
Echinococcus granulosus cysteine protease 0.0105 0.0762 0.076
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0055 0.032 0.0298
Schistosoma mansoni serine/threonine protein kinase 0.0121 0.0906 0.0904
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0068 0.0427 0.0425
Trichomonas vaginalis AGC family protein kinase 0.0162 0.1264 0.1188
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0055 0.032 0.0236
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0145 0.1117 0.104
Brugia malayi Papain family cysteine protease containing protein 0.0105 0.0762 0.0742
Plasmodium vivax unspecified product 0.0152 0.1175 0.1155
Loa Loa (eye worm) hypothetical protein 0.0244 0.2001 0.2001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0207 0.0207
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0709 0.0628
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0107 0.0104
Schistosoma mansoni tyrosine kinase 0.0151 0.1169 0.1166
Leishmania major protein kinase, putative 0.0036 0.0147 0.0144
Giardia lamblia Cathepsin B precursor 0.0333 0.2791 0.2677
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0357 0.0354
Loa Loa (eye worm) hypothetical protein 0.0105 0.0759 0.0759
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0107 0.0104
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0953 0.831 0.8309
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0175 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0178 0.1412 0.1409
Plasmodium falciparum serine repeat antigen 3 0.0055 0.032 0.0317
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.0709 0.0683
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0029 0.0086 0.0086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0183 0.018
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0427 0.0344
Entamoeba histolytica cysteine protease, putative 0.0105 0.0762 0.076
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0055 0.032 0.0317
Brugia malayi Cathepsin L-like precursor 0.005 0.0268 0.0246
Schistosoma mansoni unc-13 (munc13) 0.0124 0.0927 0.0925
Entamoeba histolytica protein kinase domain containing protein 0.1142 1 1
Entamoeba histolytica cysteine protease, putative 0.0105 0.0762 0.076
Plasmodium falciparum casein kinase II beta chain 0.0037 0.0155 0.0153
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0207 0.0205
Echinococcus granulosus protein kinase c eta type 0.0105 0.0759 0.0756
Brugia malayi RhoGAP domain containing protein 0.0105 0.0759 0.0738
Brugia malayi Cathepsin L-like precursor 0.0178 0.1412 0.1392
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0207 0.0205
Leishmania major hypothetical protein, conserved 0.0038 0.0168 0.0165
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.0762 0.076
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0121 0.0906 0.0906
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0178 0.1412 0.1409
Echinococcus multilocularis protein kinase c epsilon type 0.0285 0.2366 0.2364
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0105 0.0759 0.0756
Onchocerca volvulus Cathepsin L homolog 0.0178 0.1412 0.1388
Plasmodium vivax casein kinase II beta chain, putative 0.0037 0.0155 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0178 0.1412 0.1409
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1142 1 1
Trypanosoma cruzi casein kinase II, putative 0.0152 0.1175 0.1173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.032 0.0236
Echinococcus multilocularis hyperpolarization activated cyclic 0.0029 0.0086 0.0084
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0037 0.0155 0.0153
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0023 0.0027 0.0027
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.032 0.032
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0709 0.0628
Echinococcus multilocularis protein kinase shaggy 0.1142 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.1412 0.1337
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.005 0.0268 0.0246
Echinococcus multilocularis raf serine:threonine protein kinase 0.0108 0.0789 0.0786
Schistosoma mansoni rac gtpase activating protein 0.0105 0.0759 0.0756
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0105 0.0759 0.0756
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0207 0.0205
Schistosoma mansoni protein kinase 0.0152 0.1175 0.1173
Entamoeba histolytica protein kinase, putative 0.0032 0.0107 0.0104
Trichomonas vaginalis CMGC family protein kinase 0.0152 0.1175 0.1098
Trichomonas vaginalis AGC family protein kinase 0.0162 0.1264 0.1188
Echinococcus granulosus insulin receptor 0.0168 0.1317 0.1315
Schistosoma mansoni serine/threonine kinase 0.0162 0.1264 0.1262
Trypanosoma cruzi cysteine protease, putative 0.0105 0.0762 0.076
Schistosoma mansoni cathepsin s 0.005 0.0268 0.0266
Schistosoma mansoni casein kinase II beta subunit 0.0037 0.0155 0.0153
Trypanosoma cruzi cysteine proteinase, putative 0.0105 0.0762 0.076
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0055 0.032 0.0317
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1142 1 1
Plasmodium falciparum serine repeat antigen 6 0.0055 0.032 0.0317
Trypanosoma cruzi cruzipain precursor, putative 0.0178 0.1412 0.1409
Entamoeba histolytica protein kinase, putative 0.0051 0.0275 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.032 0.0236
Trichomonas vaginalis AGC family protein kinase 0.0162 0.1264 0.1188
Trypanosoma brucei cAMP binding protein, putative 0.0038 0.0168 0.0165
Brugia malayi Protein kinase domain containing protein 0.0162 0.1264 0.1245
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0023
Echinococcus granulosus cathepsin L 0.0105 0.0762 0.076
Giardia lamblia Hypothetical protein 0.0055 0.032 0.0167
Loa Loa (eye worm) hypothetical protein 0.0139 0.1068 0.1068
Plasmodium vivax protein kinase Crk2 0.006 0.0357 0.0335
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.032 0.0317
Entamoeba histolytica casein kinase, putative 0.0152 0.1175 0.1173
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0107 0.0104
Schistosoma mansoni tyrosine kinase 0.0168 0.1317 0.1315
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0107 0.0104
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0029 0.0086 0.0086
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0055 0.032 0.0167
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0107 0.0085
Entamoeba histolytica hypothetical protein 0.0105 0.0759 0.0756
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0147 0.0144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.0762 0.076
Giardia lamblia Cathepsin L precursor 0.0055 0.032 0.0167
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0105 0.0759 0.0756
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0055 0.032 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0336 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.032 0.0236
Leishmania major protein kinase, putative 0.0036 0.0147 0.0144
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0055 0.032 0.0167
Echinococcus multilocularis twitchin 0.0021 0.0009 0.0006
Echinococcus multilocularis Rac GTPase activating protein 1 0.0105 0.0759 0.0756
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0152 0.1175 0.1175
Loa Loa (eye worm) hypothetical protein 0.0124 0.0927 0.0927
Entamoeba histolytica cysteine protease, putative 0.0105 0.0762 0.076
Giardia lamblia Cathepsin B precursor 0.0055 0.032 0.0167
Giardia lamblia Cathepsin B precursor 0.0055 0.032 0.0167
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0709 0.0706
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0023 0.0034 0.0034
Echinococcus granulosus dna polymerase eta 0.0039 0.0175 0.0173
Trypanosoma brucei cdc2-related kinase 1 0.006 0.0357 0.0354
Plasmodium falciparum serine repeat antigen 8 0.0055 0.032 0.0317
Echinococcus granulosus N chimaerin 0.0105 0.0759 0.0756
Plasmodium vivax vivapain-2 0.0178 0.1412 0.1392
Brugia malayi MAP kinase sur-1 0.0068 0.0427 0.0406
Schistosoma mansoni kinase 0.0058 0.0346 0.0343
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0023 0.002
Schistosoma mansoni cathepsin B (C01 family) 0.0055 0.032 0.0317
Entamoeba histolytica cysteine protease, putative 0.0105 0.0762 0.076
Giardia lamblia Kinase, CMGC CDK 0.006 0.0357 0.0205
Plasmodium falciparum cysteine proteinase falcipain 1 0.0105 0.0762 0.076
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0105 0.0759 0.0759
Schistosoma mansoni cathepsin F (C01 family) 0.0178 0.1412 0.1409
Brugia malayi Cathepsin L-like cysteine proteinase 0.0128 0.0969 0.0949
Schistosoma mansoni atypical protein kinase C 0.0356 0.2994 0.2992
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0055 0.032 0.0298
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.032 0.0236
Brugia malayi cathepsin Z-like cysteine proteinase 0.0055 0.032 0.0298
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0023 0.002
Schistosoma mansoni voltage-gated potassium channel 0.0162 0.1264 0.1262
Echinococcus multilocularis roundabout 2 0.0022 0.0026 0.0023
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.032 0.0317
Trypanosoma cruzi cysteine peptidase, putative 0.0178 0.1412 0.1409
Entamoeba histolytica cysteine proteinase, putative 0.0178 0.1412 0.1409
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0155 0.0153
Leishmania major protein kinase, putative 0.0032 0.0107 0.0104
Plasmodium vivax unspecified product 0.0055 0.032 0.0298
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0155 0.007
Brugia malayi Papain family cysteine protease containing protein 0.0178 0.1412 0.1392
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0121 0.0906 0.0904
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0357 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.032 0.0236
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0107 0.0104
Onchocerca volvulus Cathepsin L homolog 0.0055 0.032 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.032 0.0236
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.0762 0.076
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0034 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.1412 0.1337
Schistosoma mansoni vesicular amine transporter 0.0021 0.0017 0.0014
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.0762 0.076
Echinococcus multilocularis cyclin dependent kinase 1 0.006 0.0357 0.0354
Leishmania major DNA polymerase eta, putative 0.0039 0.0175 0.0173
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0155 0.007
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0207 0.0205
Trichomonas vaginalis CMGC family protein kinase 0.0152 0.1175 0.1098
Onchocerca volvulus 0.0178 0.1412 0.1388
Onchocerca volvulus 0.0128 0.0969 0.0944
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.1264 0.1262
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0183 0.018
Entamoeba histolytica cysteine protease, putative 0.0055 0.032 0.0317
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0068 0.0427 0.0425
Entamoeba histolytica protein kinase, putative 0.1142 1 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0068 0.0427 0.0425
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0086 0.0084
Leishmania major hypothetical protein, conserved 0.0022 0.0023 0.002
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0178 0.1412 0.1412
Echinococcus multilocularis RNA directed DNA polymerase 0.0594 0.5115 0.5114
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0953 0.831 0.8309
Giardia lamblia Cathepsin B precursor 0.0055 0.032 0.0167
Schistosoma mansoni protein kinase C mu 0.0121 0.0906 0.0904
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.1412 0.1337
Loa Loa (eye worm) RasGEF domain-containing protein 0.0105 0.0759 0.0759
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0155 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.1412 0.1337
Entamoeba histolytica protein kinase domain containing protein 0.1142 1 1
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0357 0.0273
Leishmania major cathepsin L-like protease 0.0178 0.1412 0.1409
Loa Loa (eye worm) hypothetical protein 0.0128 0.0969 0.0969
Echinococcus multilocularis epidermal growth factor receptor 0.0151 0.1169 0.1166
Loa Loa (eye worm) hypothetical protein 0.0594 0.5115 0.5115
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.004 0.0183 0.0161
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0029 0.0086 0.0084
Giardia lamblia Cathepsin L precursor 0.0055 0.032 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0178 0.1412 0.1337
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0953 0.831 0.8309
Brugia malayi diacylglycerol kinase 0.0105 0.0759 0.0738
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0105 0.0759 0.0759
Brugia malayi Hr1 repeat family protein 0.0162 0.1264 0.1245
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0107 0.0104
Loa Loa (eye worm) hypothetical protein 0.0105 0.0759 0.0759
Onchocerca volvulus Cathepsin L homolog 0.0178 0.1412 0.1388
Loa Loa (eye worm) hypothetical protein 0.0105 0.0759 0.0759
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0055 0.032 0.0317
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.032 0.0236
Toxoplasma gondii diacylglycerol kinase, putative 0.0105 0.0759 0.0756
Entamoeba histolytica cysteine protease, putative 0.0055 0.032 0.0317
Trypanosoma brucei polo-like protein kinase 0.0099 0.0709 0.0706
Echinococcus multilocularis myotubularin protein 13 0.0105 0.0759 0.0756
Entamoeba histolytica cysteine protease, putative 0.0105 0.0762 0.076
Brugia malayi fibroinase precursor 0.0055 0.032 0.0298
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0036 0.0147 0.0144
Brugia malayi Furin-like cysteine rich region family protein 0.0238 0.1945 0.1927
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.1412 0.1337
Loa Loa (eye worm) TK/INSR protein kinase 0.0168 0.1317 0.1317
Trypanosoma cruzi cysteine peptidase, putative 0.0105 0.0762 0.076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0178 0.1412 0.1337
Loa Loa (eye worm) hypothetical protein 0.0055 0.032 0.032
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0709 0.0628
Loa Loa (eye worm) hypothetical protein 0.0105 0.0759 0.0759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.032 0.0236
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0029 0.0086 0.0084
Trichomonas vaginalis AGC family protein kinase 0.0162 0.1264 0.1188
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0055 0.032 0.032
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0068 0.0427 0.0425
Onchocerca volvulus 0.0139 0.1068 0.1043
Echinococcus granulosus serine:threonine protein kinase N2 0.0162 0.1264 0.1262
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0107 0.0104
Trypanosoma cruzi cdc2-related kinase 3 0.006 0.0357 0.0354
Entamoeba histolytica cysteine proteinase 2 0.0105 0.0762 0.076
Echinococcus granulosus cyclin dependent kinase 5 0.006 0.0357 0.0354
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0178 0.1412 0.1409
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0107 0.0104
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0029 0.0086 0.0084
Plasmodium falciparum protein kinase 5 0.006 0.0357 0.0354
Echinococcus multilocularis cysteine protease 0.0178 0.1412 0.1409
Trichomonas vaginalis CMGC family protein kinase 0.0152 0.1175 0.1098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0178 0.1412 0.1337
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0107 0.0104
Trypanosoma cruzi cAMP binding protein, putative 0.0038 0.0168 0.0165
Loa Loa (eye worm) hypothetical protein 0.0032 0.0107 0.0107
Plasmodium falciparum serine repeat antigen 4 0.0055 0.032 0.0317
Schistosoma mansoni tyrosine kinase 0.0147 0.1139 0.1136
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.0709 0.0706
Brugia malayi Protein kinase domain containing protein 0.0121 0.0906 0.0886
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0023 0.002
Echinococcus multilocularis protein kinase c iota type 0.035 0.294 0.2938
Schistosoma mansoni cathepsin F (C01 family) 0.0128 0.0969 0.0967
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0037 0.0155 0.0128
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.006 0.0357 0.0354
Trichomonas vaginalis casein kinase II beta chain, putative 0.0037 0.0155 0.007
Schistosoma mansoni protein kinase 0.0142 0.1094 0.1091
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0028 0.0071 0.0069
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0138 0.1056 0.0979
Echinococcus multilocularis Diacylglycerol kinase theta 0.0105 0.0759 0.0756
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.0709 0.0706
Brugia malayi Cam kinase protein 1 0.0032 0.0107 0.0085
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0037 0.0155 0.0153
Brugia malayi Protein kinase domain containing protein 0.0162 0.1264 0.1245
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0148 0.1143 0.1141
Trypanosoma brucei cdc2-related kinase 3 0.006 0.0357 0.0354
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0105 0.0762 0.076
Giardia lamblia Cysteine protease 0.0055 0.032 0.0167
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.032 0.0298
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0055 0.032 0.0298
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0043 0.0207 0.0185
Brugia malayi Protein kinase domain containing protein 0.0061 0.0369 0.0348
Echinococcus granulosus Protein kinase C brain isozyme 0.0879 0.7655 0.7655
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0107 0.0085
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0029 0.0086 0.0084
Brugia malayi cathepsin L-like cysteine proteinase 0.0055 0.032 0.0298
Schistosoma mansoni diacylglycerol kinase theta 0.0105 0.0759 0.0756
Echinococcus multilocularis mitogen activated protein kinase 3 0.0068 0.0427 0.0425
Plasmodium vivax unspecified product 0.005 0.0268 0.0246
Echinococcus multilocularis dna polymerase eta 0.0039 0.0175 0.0173
Echinococcus granulosus cathepsin L cysteine proteinase 0.0178 0.1412 0.1409
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0068 0.0427 0.0427
Echinococcus granulosus Diacylglycerol kinase theta 0.0105 0.0759 0.0756
Onchocerca volvulus 0.0105 0.0759 0.0733
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0055 0.032 0.0317

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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