Detailed information for compound 906683

Basic information

Technical information
  • TDR Targets ID: 906683
  • Name: 3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benz amide
  • MW: 437.351 | Formula: C19H21BrN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cccc(c1)NC(=O)c1cccc(c1)S(=O)(=O)N1CCCCCC1
  • InChi: 1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)
  • InChiKey: IYAYHZZWYNXHEQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(1-azepanylsulfonyl)-N-(3-bromophenyl)benzamide
  • EU-0004902
  • Oprea1_876929
  • ZINC01159030

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sirtuin 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana silent information regulator 2, putative,NAD-dependent SIR2, putative Get druggable targets OG5_127826 All targets in OG5_127826
Trypanosoma congolense silent information regulator 2 Get druggable targets OG5_127826 All targets in OG5_127826
Leishmania braziliensis NAD-dependent SIR2, putative Get druggable targets OG5_127826 All targets in OG5_127826
Schistosoma mansoni chromatin regulatory protein sir2 Get druggable targets OG5_127826 All targets in OG5_127826
Trypanosoma cruzi Silent information regulator 2 related protein 1 Get druggable targets OG5_127826 All targets in OG5_127826
Trichomonas vaginalis chromatin regulatory protein sir2, putative Get druggable targets OG5_127826 All targets in OG5_127826
Schistosoma japonicum ko:K01463 sirtuin (silent mating type information regulation 2 homolog) 2 [EC:3.5.1.-], putative Get druggable targets OG5_127826 All targets in OG5_127826
Leishmania donovani Silent information regulator 2 related protein 1 Get druggable targets OG5_127826 All targets in OG5_127826
Brugia malayi transcriptional regulator, Sir2 family protein Get druggable targets OG5_127826 All targets in OG5_127826
Loa Loa (eye worm) transcriptional regulator Get druggable targets OG5_127826 All targets in OG5_127826
Trypanosoma brucei Silent information regulator 2 related protein 1 Get druggable targets OG5_127826 All targets in OG5_127826
Candida albicans likely SIR2 family histone deacetylase similar to S. cerevisiae HST2 (YPL015C) involved in telomeric chromatin silencing Get druggable targets OG5_127826 All targets in OG5_127826
Trichomonas vaginalis chromatin regulatory protein sir2, putative Get druggable targets OG5_127826 All targets in OG5_127826
Schistosoma mansoni chromatin regulatory protein sir2 Get druggable targets OG5_127826 All targets in OG5_127826
Trypanosoma brucei gambiense silent information regulator 2,NAD-dependent SIR2 Get druggable targets OG5_127826 All targets in OG5_127826
Echinococcus multilocularis chromatin regulatory protein sir2 Get druggable targets OG5_127826 All targets in OG5_127826
Leishmania major silent information regulator 2, putative Get druggable targets OG5_127826 All targets in OG5_127826
Entamoeba histolytica Sir2 family transcriptional regulator, putative Get druggable targets OG5_127826 All targets in OG5_127826
Candida albicans likely SIR2 family histone deacetylase similar to S. cerevisiae HST2 (YPL015C) involved in telomeric chromatin silencing Get druggable targets OG5_127826 All targets in OG5_127826
Echinococcus granulosus chromatin regulatory protein sir2 Get druggable targets OG5_127826 All targets in OG5_127826
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 Get druggable targets OG5_127826 All targets in OG5_127826
Entamoeba histolytica Sir2 family transcriptional regulator, putative Get druggable targets OG5_127826 All targets in OG5_127826
Leishmania infantum silent information regulator 2, putative Get druggable targets OG5_127826 All targets in OG5_127826
Trypanosoma cruzi Silent information regulator 2 related protein 1 Get druggable targets OG5_127826 All targets in OG5_127826
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 Get druggable targets OG5_127826 All targets in OG5_127826
Giardia lamblia Hypothetical protein Get druggable targets OG5_127826 All targets in OG5_127826
Schistosoma mansoni chromatin regulatory protein sir2 Get druggable targets OG5_127826 All targets in OG5_127826
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum transcriptional regulatory protein sir2a sirtuin 2 234 aa 207 aa 26.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0037 0.0039 0.0036
Plasmodium vivax vivapain-2 0.1052 0.1875 1
Onchocerca volvulus 0.1052 0.1875 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0025 0.0025
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0326 0.0561 0.0558
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0326 0.0561 0.0558
Echinococcus granulosus cysteine protease 0.062 0.1094 0.1091
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.005 0.0231
Schistosoma mansoni importin beta-1 0.0028 0.0022 0.002
Entamoeba histolytica cysteine proteinase, putative 0.062 0.1094 0.5816
Entamoeba histolytica cysteine protease, putative 0.062 0.1094 0.5816
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0036 0.0034
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.0007 0.0005
Plasmodium falciparum serine repeat antigen 6 0.0326 0.0561 0.2963
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0037 0.0037
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.001 0.0059
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.062 0.1094 0.1091
Loa Loa (eye worm) hypothetical protein 0.0326 0.0561 0.0561
Schistosoma mansoni intermediate filament proteins 0.0029 0.0025 0.0022
Mycobacterium ulcerans hypothetical protein 0.0036 0.0036 0.3952
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0326 0.0561 0.1594
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.0265 0.0265
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0044 0.0196
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1052 0.1875 0.1873
Giardia lamblia DINP protein human, muc B family 0.0021 0.001 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0006
Echinococcus granulosus cathepsin l1 0.1052 0.1875 0.1873
Mycobacterium tuberculosis Conserved protein 0.0036 0.0036 0.0766
Onchocerca volvulus 0.0758 0.1342 0.7121
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.0007 0.0005
Echinococcus multilocularis snurportin 1 0.03 0.0515 0.0512
Mycobacterium tuberculosis Conserved protein 0.0036 0.0036 0.0766
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0069 0.0176
Giardia lamblia Cathepsin L precursor 0.0326 0.0561 0.1594
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0326 0.0561 0.1594
Onchocerca volvulus 0.1052 0.1875 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0081 1
Brugia malayi Cathepsin L-like precursor 0.1052 0.1875 0.1875
Giardia lamblia Cysteine protease 0.0326 0.0561 0.1594
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.001 0.001
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0326 0.0561 0.2963
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0037 0.0084
Schistosoma mansoni hypothetical protein 0.0185 0.0306 0.0304
Leishmania major cathepsin L-like protease 0.1098 0.1958 0.5617
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0326 0.0561 0.0558
Onchocerca volvulus Cathepsin L homolog 0.1052 0.1875 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0326 0.0561 0.0561
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.001 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1052 0.1875 0.5378
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1052 0.1875 0.5378
Plasmodium falciparum serine repeat antigen 3 0.0326 0.0561 0.2963
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0326 0.0561 0.1594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1052 0.1875 0.5378
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0022 0.002
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0135 0.0215 0.111
Entamoeba histolytica cysteine proteinase, putative 0.062 0.1094 0.5816
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0069 0.0176
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0036 0.0029
Schistosoma mansoni ran 0.0021 0.0009 0.0006
Entamoeba histolytica cysteine protease, putative 0.0326 0.0561 0.2963
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0326 0.0561 0.2963
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0006
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0326 0.0561 0.0561
Echinococcus multilocularis cathepsin L cysteine protease 0.1052 0.1875 0.1873
Entamoeba histolytica cysteine proteinase, putative 0.1052 0.1875 1
Brugia malayi Cathepsin L-like precursor 0.1052 0.1875 0.1875
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0025
Schistosoma mansoni cathepsin F (C01 family) 0.1052 0.1875 0.1873
Schistosoma mansoni ran 0.0021 0.0009 0.0006
Echinococcus granulosus cathepsin L 0.0326 0.0561 0.0558
Leishmania major DNA polymerase kappa, putative 0.0021 0.001 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.001 0.0002
Entamoeba histolytica cysteine proteinase, putative 0.1052 0.1875 1
Echinococcus multilocularis cathepsin L 0.062 0.1094 0.1091
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0326 0.0561 0.2963
Leishmania major DNA polymerase eta, putative 0.0021 0.001 0.0006
Trypanosoma cruzi cysteine peptidase, putative 0.1098 0.1958 0.1952
Giardia lamblia Cathepsin L precursor 0.0326 0.0561 0.1594
Echinococcus granulosus dna polymerase eta 0.0021 0.001 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.5544 1 1
Giardia lamblia Cysteine protease 0.0326 0.0561 0.1594
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.0009
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0069 0.0176
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.0007 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1052 0.1875 0.5378
Plasmodium falciparum serine repeat antigen 5 0.0326 0.0561 0.2963
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0185 0.0306 0.0303
Echinococcus multilocularis cysteine protease 0.1052 0.1875 0.1873
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.062 0.1094 0.1087
Loa Loa (eye worm) transcriptional regulator 0.002 0.0007 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.001 0.0006
Entamoeba histolytica cysteine protease, putative 0.062 0.1094 0.5816
Loa Loa (eye worm) cysteine protease 0.1052 0.1875 0.1875
Brugia malayi Cathepsin L-like precursor 0.1052 0.1875 0.1875
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0326 0.0561 0.1594
Trypanosoma brucei cysteine peptidase C (CPC) 0.194 0.348 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0326 0.0561 0.1594
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0036 0.0155
Giardia lamblia Cathepsin L precursor 0.0326 0.0561 0.1594
Entamoeba histolytica cysteine protease, putative 0.062 0.1094 0.5816
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0222 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0029 0.0024 0.0024
Onchocerca volvulus 0.0036 0.0036 0.0063
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0036 0.0036
Onchocerca volvulus 0.1052 0.1875 1
Schistosoma mansoni cathepsin F (C01 family) 0.1052 0.1875 0.1873
Leishmania major silent information regulator 2, putative 0.0135 0.0215 0.0597
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0003 0.0003
Plasmodium falciparum serine repeat antigen 8 0.0326 0.0561 0.2963
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.002 0.0007 0.0005
Brugia malayi transcriptional regulator, Sir2 family protein 0.002 0.0007 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0207 0.0207
Loa Loa (eye worm) ctsf protein 0.1052 0.1875 0.1875
Onchocerca volvulus 0.1052 0.1875 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0326 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.1052 0.1875 0.1875
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.194 0.348 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.001 0.0006
Echinococcus granulosus cathepsin L cysteine proteinase 0.1052 0.1875 0.1873
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1052 0.1875 0.5378
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0039
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0036 0.0766
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0009 0.0006
Trypanosoma cruzi cysteine peptidase, putative 0.062 0.1094 0.1087
Plasmodium vivax unspecified product 0.0295 0.0504 0.2661
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0326 0.0561 0.1594
Giardia lamblia Hypothetical protein 0.0326 0.0561 0.1594
Brugia malayi Papain family cysteine protease containing protein 0.1052 0.1875 0.1875
Schistosoma mansoni alpha-glucosidase 0.014 0.0224 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0326 0.0561 0.1594
Giardia lamblia Cathepsin B precursor 0.194 0.348 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.001 0.0012
Entamoeba histolytica cysteine protease, putative 0.062 0.1094 0.5816
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1052 0.1875 0.5378
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0069 0.0066
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.001 0.0002
Echinococcus granulosus cathepsin L 0.062 0.1094 0.1091
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0013 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0326 0.0561 0.1594
Onchocerca volvulus Cathepsin F homolog 0.1052 0.1875 1
Onchocerca volvulus 0.1052 0.1875 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1052 0.1875 0.5378
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0036 0.0084
Entamoeba histolytica cysteine protease, putative 0.0326 0.0561 0.2963
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1052 0.1875 0.1875
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1052 0.1875 0.5378
Brugia malayi cathepsin L-like cysteine proteinase 0.0326 0.0561 0.0561
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.001 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0036 0.0084
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.5544 1 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0037 0.0156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1098 0.1958 0.5617
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.0515 0.0515
Trypanosoma cruzi cysteine peptidase, putative 0.1098 0.1958 0.1952
Brugia malayi beta-lactamase family protein 0.0036 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0326 0.0561 0.1594
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0326 0.0561 0.2963
Schistosoma mansoni cathepsin F (C01 family) 0.0758 0.1342 0.134
Giardia lamblia Cathepsin B precursor 0.194 0.348 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.194 0.348 0.3478
Brugia malayi beta-lactamase family protein 0.0036 0.0036 0.0036
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.024 0.0238
Plasmodium falciparum serine repeat antigen 2 0.0326 0.0561 0.2963
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1098 0.1958 0.5617
Brugia malayi cathepsin L-like precursor 0.0758 0.1342 0.1342
Entamoeba histolytica hypothetical protein 0.0326 0.0561 0.2963
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.0265 0.0262
Echinococcus multilocularis cathepsin b 0.5544 1 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.002 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Entamoeba histolytica cysteine proteinase 1, putative 0.062 0.1094 0.5816
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0326 0.0561 0.0558
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0036 0.3952
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.024 0.024
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.0265 0.0265
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.0008
Onchocerca volvulus 0.1052 0.1875 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0037 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1052 0.1875 0.5378
Onchocerca volvulus Cathepsin L homolog 0.0326 0.0561 0.2897
Brugia malayi NAD-dependent deacetylase SIRT1 0.002 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1098 0.1958 0.5617
Trypanosoma cruzi major cysteine proteinase, putative 0.0326 0.0561 0.0554
Echinococcus granulosus intermediate filament protein 0.0029 0.0025 0.0022
Echinococcus multilocularis geminin 0.0185 0.0306 0.0304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.062 0.1094 0.3128
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0036 0.0034
Trypanosoma cruzi cysteine protease, putative 0.062 0.1094 0.1087
Trichomonas vaginalis ran, putative 0.0021 0.0009 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0036 0.0084
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0326 0.0561 0.0558
Leishmania major cathepsin L-like protease 0.1052 0.1875 0.5378
Leishmania major hypothetical protein, conserved 0.0036 0.0036 0.0084
Giardia lamblia Cathepsin B precursor 0.0326 0.0561 0.1594
Trypanosoma cruzi cysteine peptidase, putative 0.1098 0.1958 0.1952
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0044 0.0105
Loa Loa (eye worm) hypothetical protein 0.0758 0.1342 0.1342
Leishmania major cathepsin L-like protease 0.1098 0.1958 0.5617
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0326 0.0561 0.1594
Echinococcus multilocularis lamin dm0 0.0029 0.0025 0.0022
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0036 0.0766
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.062 0.1094 0.3128
Trichomonas vaginalis conserved hypothetical protein 0.0326 0.0561 0.1594
Entamoeba histolytica cysteine protease, putative 0.062 0.1094 0.5816
Trypanosoma brucei protein kinase, putative 0.0054 0.0069 0.0176
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0036 0.0766
Plasmodium falciparum importin beta, putative 0.0028 0.0022 0.008
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.007 0.007
Brugia malayi RNA, U transporter 1 0.008 0.0116 0.0116
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0326 0.0561 0.2963
Echinococcus multilocularis dna polymerase eta 0.0021 0.001 0.0007
Giardia lamblia Cathepsin L precursor 0.0326 0.0561 0.1594
Echinococcus granulosus cathepsin l1 0.0758 0.1342 0.134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1052 0.1875 0.5378
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0326 0.0561 0.1594
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0036 0.0766
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0037 0.0084
Trypanosoma cruzi cruzipain precursor, putative 0.0295 0.0504 0.0497
Echinococcus granulosus cathepsin l cysteine peptidase 0.1052 0.1875 0.1873
Leishmania major cathepsin L-like protease 0.1098 0.1958 0.5617
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1052 0.1875 0.5378
Onchocerca volvulus Cathepsin L homolog 0.1052 0.1875 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0036 0.0766
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.005 0.0124
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0326 0.0561 0.2963
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0009 0.0008
Loa Loa (eye worm) acetyltransferase 0.0149 0.024 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1052 0.1875 0.5378
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0036 0.0766
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.001 0.0006
Schistosoma mansoni chromatin regulatory protein sir2 0.0135 0.0215 0.0212
Loa Loa (eye worm) hypothetical protein 0.5544 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.007 0.007
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0025 0.0025
Plasmodium falciparum serine repeat antigen 1 0.0326 0.0561 0.2963
Loa Loa (eye worm) hypothetical protein 0.0326 0.0561 0.0561
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.001 0.0006
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0295 0.0504 0.0504
Giardia lamblia Hypothetical protein 0.0135 0.0215 0.0597
Entamoeba histolytica cysteine protease, putative 0.1052 0.1875 1
Entamoeba histolytica cysteine proteinase, putative 0.062 0.1094 0.5816
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0326 0.0561 0.0561
Mycobacterium ulcerans beta-lactamase 0.0036 0.0036 0.3952
Brugia malayi Cathepsin L-like precursor 0.1052 0.1875 0.1875
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Echinococcus multilocularis cathepsin L cysteine protease 0.1052 0.1875 0.1873
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.0386 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.005 0.0124
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.001 0.0007
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0009 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0326 0.0561 0.1594
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0022 0.0043
Loa Loa (eye worm) hypothetical protein 0.0326 0.0561 0.0561
Brugia malayi Cathepsin L-like precursor 0.0758 0.1342 0.1342
Plasmodium falciparum serine repeat antigen 7 0.0326 0.0561 0.2963
Brugia malayi Cathepsin L-like precursor 0.0758 0.1342 0.1342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1052 0.1875 0.5378
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0081 0.0078
Loa Loa (eye worm) cathepsin B 0.194 0.348 0.348
Entamoeba histolytica cysteine protease, putative 0.0326 0.0561 0.2963
Mycobacterium ulcerans lipase LipD 0.0036 0.0036 0.3952
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0013 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.005 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0006
Brugia malayi Papain family cysteine protease containing protein 0.0326 0.0561 0.0561
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0081 1
Brugia malayi Papain family cysteine protease containing protein 0.062 0.1094 0.1094
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0037 0.0029
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0069 0.0061
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0037 0.0084
Trypanosoma cruzi cysteine peptidase, putative 0.0295 0.0504 0.0497
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0036 0.0034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1052 0.1875 0.5378
Brugia malayi MAP kinase sur-1 0.0054 0.0069 0.0069
Trichomonas vaginalis esterase, putative 0.0036 0.0036 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1098 0.1958 0.5617
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0326 0.0561 0.1594
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Leishmania major cathepsin L-like protease 0.1052 0.1875 0.5378
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.005 0.0048
Plasmodium vivax vivapain-3 0.062 0.1094 0.5816
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0009 0.0006
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0295 0.0504 0.0504
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0135 0.0215 0.0597
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.5544 1 1
Giardia lamblia Hypothetical protein 0.0326 0.0561 0.1594
Echinococcus multilocularis cathepsin b 0.5544 1 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0037 0.0084
Entamoeba histolytica cysteine protease, putative 0.0326 0.0561 0.2963
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.001 0.0006
Giardia lamblia Cathepsin L precursor 0.0326 0.0561 0.1594
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0326 0.0561 0.2963
Plasmodium vivax vivapain-1 0.062 0.1094 0.5816
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0037 0.0084
Brugia malayi Importin beta-1 subunit 0.0028 0.0022 0.0022
Trypanosoma cruzi cysteine proteinase, putative 0.062 0.1094 0.1087
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0326 0.0561 0.2963
Loa Loa (eye worm) transcriptional regulator 0.0135 0.0215 0.0215
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.194 0.348 1
Entamoeba histolytica cysteine proteinase, putative 0.062 0.1094 0.5816
Echinococcus granulosus dna polymerase kappa 0.0021 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0758 0.1342 0.1342
Echinococcus granulosus importin subunit beta 1 0.0028 0.0022 0.002
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0135 0.0215 0.111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1098 0.1958 0.5617
Giardia lamblia Cysteine protease 0.0326 0.0561 0.1594
Entamoeba histolytica cysteine proteinase, putative 0.0758 0.1342 0.7147
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Loa Loa (eye worm) transcriptional regulator 0.002 0.0007 0.0007
Echinococcus granulosus lamin dm0 0.0029 0.0025 0.0022
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0081 0.0078
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.001 0.0059
Brugia malayi Cathepsin L-like precursor 0.1052 0.1875 0.1875
Brugia malayi cathepsin F-like cysteine proteinase 0.0295 0.0504 0.0504
Giardia lamblia Cathepsin B precursor 0.0326 0.0561 0.1594
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0081 0.0078
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.0009
Brugia malayi cathepsin Z-like cysteine proteinase 0.0326 0.0561 0.0561
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0326 0.0561 0.0558
Brugia malayi cathepsin F-like cysteine proteinase 0.0326 0.0561 0.0561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1052 0.1875 0.5378
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0326 0.0561 0.1594
Leishmania major cathepsin L-like protease 0.1052 0.1875 0.5378
Brugia malayi Cathepsin L-like precursor 0.1052 0.1875 0.1875
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1052 0.1875 0.5378
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1052 0.1875 0.5378
Echinococcus multilocularis cysteine protease 0.1052 0.1875 0.1873
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1052 0.1875 1
Entamoeba histolytica cysteine proteinase 2 0.062 0.1094 0.5816
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0003
Toxoplasma gondii cathepsin CPC1 0.0326 0.0561 0.1594
Giardia lamblia Cathepsin B precursor 0.0326 0.0561 0.1594
Giardia lamblia Cathepsin L precursor 0.0326 0.0561 0.1594
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0036 0.0036
Giardia lamblia Cathepsin B precursor 0.0326 0.0561 0.1594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0758 0.1342 0.3844
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.062 0.1094 0.1091
Brugia malayi cathepsin Z-like cysteine proteinase 0.0326 0.0561 0.0561
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0069 0.0061
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.001 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1052 0.1875 0.5378
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0037 0.0084
Schistosoma mansoni lamin 0.0029 0.0025 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1098 0.1958 0.5617
Toxoplasma gondii cathepsin B 0.194 0.348 1
Giardia lamblia Cathepsin L-like protease 0.0326 0.0561 0.1594
Echinococcus granulosus cathepsin b 0.5544 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.062 0.1094 0.1087
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0069 0.0176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1052 0.1875 0.5378
Entamoeba histolytica cysteine protease, putative 0.062 0.1094 0.5816
Brugia malayi transcriptional regulator, Sir2 family protein 0.0135 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0758 0.1342 0.1342
Loa Loa (eye worm) hypothetical protein 0.0295 0.0504 0.0504
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0326 0.0561 0.1594
Onchocerca volvulus 0.0326 0.0561 0.2897
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0326 0.0561 0.1594
Trypanosoma cruzi major cysteine proteinase, putative 0.0372 0.0644 0.0637
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0135 0.0215 0.0597
Schistosoma mansoni chromatin regulatory protein sir2 0.0135 0.0215 0.0212
Giardia lamblia Cysteine protease 0.0326 0.0561 0.1594
Entamoeba histolytica cysteine protease, putative 0.062 0.1094 0.5816
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0135 0.0215 0.0208
Loa Loa (eye worm) hypothetical protein 0.0222 0.0373 0.0373
Toxoplasma gondii ABC1 family protein 0.0036 0.0036 0.0084
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0009 0.0002
Echinococcus granulosus cathepsin b 0.5544 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1052 0.1875 0.5378
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0069 0.0176
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0037 0.0084
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0037 0.0156
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0326 0.0561 0.0561
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.001 0.0304
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0326 0.0561 0.0558
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0069 0.0176
Echinococcus multilocularis cathepsin L 0.0326 0.0561 0.0558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1052 0.1875 0.5378
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0069 0.0061
Schistosoma mansoni hypothetical protein 0.03 0.0515 0.0512
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.5544 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.0233 0.023
Toxoplasma gondii cathepsin CPL 0.1052 0.1875 0.5378
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0044 0.0196
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0036 0.5
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0135 0.0215 0.0212
Loa Loa (eye worm) sirtuin 4 0.002 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1098 0.1958 0.5617
Entamoeba histolytica cysteine protease, putative 0.062 0.1094 0.5816
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.001 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1098 0.1958 0.5617
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0326 0.0561 0.0558
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0037 0.0084
Echinococcus granulosus cathepsin L cysteine protease 0.062 0.1094 0.1091
Plasmodium vivax unspecified product 0.0326 0.0561 0.2963
Plasmodium vivax serine-repeat antigen (SERA) 0.0326 0.0561 0.2963
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0069 0.0061
Leishmania major GTP-binding protein, putative 0.0021 0.0009 0.0005
Schistosoma mansoni cathepsin s 0.0295 0.0504 0.0502
Loa Loa (eye worm) hypothetical protein 0.0326 0.0561 0.0561
Brugia malayi beta-lactamase 0.0036 0.0036 0.0036
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1052 0.1875 1
Plasmodium falciparum serine repeat antigen 9 0.0326 0.0561 0.2963
Giardia lamblia Encystation-specific protease 0.0326 0.0561 0.1594
Plasmodium falciparum cysteine proteinase falcipain 3 0.1052 0.1875 1
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0069 0.0176
Entamoeba histolytica cysteine protease, putative 0.0326 0.0561 0.2963
Leishmania major importin beta-1 subunit, putative 0.0023 0.0013 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.062 0.1094 0.3128
Entamoeba histolytica Ran family GTPase 0.0021 0.0009 0.0008
Echinococcus granulosus snurportin 1 0.03 0.0515 0.0512
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0326 0.0561 0.0558
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0022 0.0043
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0804 0.1425 0.1419
Echinococcus granulosus lamin 0.0029 0.0025 0.0022
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.002 0.0007 0.0005
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0207 0.0207
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0326 0.0561 0.1594
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0006
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0326 0.0561 0.2963
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1098 0.1958 0.5617
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0009 0.0005
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0326 0.0561 0.1594
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0326 0.0561 0.1594
Entamoeba histolytica cysteine protease, putative 0.062 0.1094 0.5816
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0326 0.0561 0.2963
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0081 0.0078
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0036 0.0084
Loa Loa (eye worm) fibroinase 0.1052 0.1875 0.1875
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0039 0.0039
Onchocerca volvulus 0.1052 0.1875 1
Trypanosoma cruzi cruzipain precursor, putative 0.1098 0.1958 0.1952
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1052 0.1875 0.5378
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.002 0.0007 0.0005
Brugia malayi Cathepsin L-like precursor 0.0295 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0036 0.0029
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.5544 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0758 0.1342 0.1342
Plasmodium vivax unspecified product 0.062 0.1094 0.5816
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0326 0.0561 0.2963
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.0022
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0135 0.0215 0.0208
Schistosoma mansoni cathepsin C 0.0326 0.0561 0.0558
Leishmania major cathepsin L-like protease 0.1052 0.1875 0.5378
Plasmodium vivax vivapain-2 0.1052 0.1875 1
Echinococcus multilocularis dna polymerase kappa 0.0021 0.001 0.0007
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0013 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.001 0.0002
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0081 0.0211
Plasmodium falciparum cysteine proteinase falcipain 1 0.062 0.1094 0.5816
Loa Loa (eye worm) hypothetical protein 0.0295 0.0504 0.0504
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.001 0.0304
Onchocerca volvulus 0.0036 0.0036 0.0063
Plasmodium vivax importin-beta 2, putative 0.0028 0.0022 0.008
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1052 0.1875 0.1873
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0326 0.0561 0.2963
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0081 0.0211
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0003 0.0003
Loa Loa (eye worm) beta-lactamase 0.0036 0.0036 0.0036
Echinococcus multilocularis chromatin regulatory protein sir2 0.0135 0.0215 0.0212
Schistosoma mansoni cathepsin S (C01 family) 0.0326 0.0561 0.0558
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0025 0.0025
Entamoeba histolytica hypothetical protein 0.0023 0.0013 0.0029
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0185 0.0306 0.0303
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0069 0.0066
Brugia malayi MH2 domain containing protein 0.013 0.0207 0.0207
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0037 0.0034
Brugia malayi intermediate filament protein 0.0029 0.0025 0.0025
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0013 0.0016
Schistosoma mansoni hypothetical protein 0.0185 0.0306 0.0304
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0036 0.0084
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.002 0.0007 0.0005
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1052 0.1875 0.1875
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0069 0.0176
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0036 0.0766
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0326 0.0561 0.1594
Trichomonas vaginalis conserved hypothetical protein 0.0326 0.0561 0.1594
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.0007 0.0005
Brugia malayi Papain family cysteine protease containing protein 0.062 0.1094 0.1094
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0265 0.0262
Schistosoma mansoni DNA polymerase eta 0.0021 0.001 0.0007
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.194 0.348 0.3475
Trypanosoma brucei unspecified product 0.0021 0.001 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0081 1
Giardia lamblia Cathepsin L-like protease 0.0326 0.0561 0.1594
Schistosoma mansoni cathepsin B (C01 family) 0.0326 0.0561 0.0558
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0009 0.0002
Echinococcus multilocularis musashi 0.0029 0.0025 0.0022
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0135 0.0215 0.0212
Brugia malayi fibroinase precursor 0.0326 0.0561 0.0561
Onchocerca volvulus 0.0036 0.0036 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1098 0.1958 0.5617
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.001 0.001
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.001 0.0007
Echinococcus granulosus chromatin regulatory protein sir2 0.0135 0.0215 0.0212
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.062 0.1094 0.1091
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0036 0.3952
Schistosoma mansoni chromatin regulatory protein sir2 0.0135 0.0215 0.0212
Trypanosoma brucei glucosidase, putative 0.0036 0.0037 0.0084
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0081 0.1938
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.001 0.0006
Echinococcus multilocularis lamin 0.0029 0.0025 0.0022
Brugia malayi Papain family cysteine protease containing protein 0.0326 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0295 0.0504 0.0504
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0037 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1052 0.1875 0.5378
Plasmodium falciparum serine repeat antigen 4 0.0326 0.0561 0.2963
Brugia malayi transcriptional regulator, Sir2 family protein 0.002 0.0007 0.0007
Leishmania major cysteine peptidase A (CPA) 0.1052 0.1875 0.5378
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0069 0.0176
Mycobacterium tuberculosis Conserved protein 0.0036 0.0036 0.0766
Plasmodium vivax serine-repeat antigen (SERA) 0.0326 0.0561 0.2963
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0036 0.0084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0326 0.0561 0.1594
Brugia malayi Papain family cysteine protease containing protein 0.0326 0.0561 0.0561
Echinococcus granulosus geminin 0.0185 0.0306 0.0304
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0326 0.0561 0.2963
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0037 0.0037
Brugia malayi cathepsin L precursor 0.0326 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0326 0.0561 0.0561
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0037 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0069 0.0066
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0022 0.0043
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0326 0.0561 0.2963
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.062 0.1094 0.3128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.001 0.0002
Toxoplasma gondii preprocathepsin c precursor, putative 0.0326 0.0561 0.1594
Entamoeba histolytica cysteine protease, putative 0.062 0.1094 0.5816
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.024 0.0238
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0037 0.0084
Entamoeba histolytica cysteine protease, putative 0.062 0.1094 0.5816
Entamoeba histolytica cysteine protease, putative 0.0326 0.0561 0.2963
Entamoeba histolytica cysteine protease, putative 0.062 0.1094 0.5816
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0265 0.0262
Schistosoma mansoni lamin 0.0029 0.0025 0.0022
Mycobacterium leprae Probable lipase LipE 0.0036 0.0036 0.5
Giardia lamblia Cathepsin B precursor 0.0326 0.0561 0.1594
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1098 0.1958 0.5617
Schistosoma mansoni alpha-glucosidase 0.014 0.0224 0.0221
Onchocerca volvulus 0.0094 0.0141 0.0629
Trypanosoma cruzi cysteine peptidase, putative 0.1052 0.1875 0.1869
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1052 0.1875 0.5378
Leishmania major cathepsin L-like protease 0.1052 0.1875 0.5378
Giardia lamblia Cathepsin B precursor 0.194 0.348 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0036 0.0034
Toxoplasma gondii cathepsin CPC2 0.0326 0.0561 0.1594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0758 0.1342 0.3844
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0326 0.0561 0.2963
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.002 0.0007 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1052 0.1875 0.5378
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0069 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.001 0.0006
Schistosoma mansoni alpha glucosidase 0.0036 0.0037 0.0034
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0069 0.0069
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0135 0.0215 0.0597
Entamoeba histolytica cysteine protease, putative 0.062 0.1094 0.5816
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0069 0.0066
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.001 0.0002
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.005 0.0124

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 20 % Cell cycle arrest in human MCF7 cells assessed as accumulation at S phase at 50 uM after 24 hrs by flow cytometry (Rvb = 30.8 %) ChEMBL. 24340169
IC50 (binding) = 15.5 uM Inhibition of recombinant human full length SIRT2 using fluorescent ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assay ChEMBL. 24340169
IC50 (binding) = 15.5 uM Inhibition of SIRT-2 (unknown origin) ChEMBL. 24602787
IC50 (binding) = 15.5 uM Inhibition of SIRT-2 (unknown origin) ChEMBL. No reference
IC50 (binding) = 15.5 uM Inhibition of SIRT2 (unknown origin) ChEMBL. 26005542
IC50 (binding) = 16 uM Inhibition of human recombinant SIRT2 ChEMBL. 25515955
IC50 (binding) > 50 uM Inhibition of human SIRT1 ChEMBL. 25515955
IC50 (binding) > 50 uM Inhibition of human SIRT3 ChEMBL. 25515955
Inhibition (binding) Inhibition of SIRT2 in human MCF7 cells assessed as increase in hyperacetylation of alpha-tubulin up to 50 uM after 24 hrs by Western blot analysis ChEMBL. 24340169
Inhibition (binding) = 11 % Inhibition of GST-tagged human recombinant SIRT2 (34 to 356 residues) expressed in Escherichia coli BL21 at 10 uM using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 45 mins by fluorimetric analysis ChEMBL. 25515955
Inhibition (binding) < 25 % Inhibition of recombinant human N-tagged GST-SIRT1 fusion protein using fluorescent ZMAL as substrate at 50 uM after 4 hrs by homogeneous fluorescent deacetylase assay ChEMBL. 24340169

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.