Detailed information for compound 923867

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 364.312 | Formula: C18H12N4O5
  • H donors: 0 H acceptors: 5 LogP: 2.66 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1ccc2c(o1)ccc(c2)OCc1nnn(c1)c1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C18H12N4O5/c23-18-7-4-12-8-16(5-6-17(12)27-18)26-11-13-10-21(20-19-13)14-2-1-3-15(9-14)22(24)25/h1-10H,11H2
  • InChiKey: JUWQXLXNRGKUMT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0289
Trichomonas vaginalis receptor histidine kinase, putative 0.0027 0.0136 0.037
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0048 0.04 0.1335
Schistosoma mansoni hypothetical protein 0.0169 0.1924 0.2269
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0089 0.0759
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0194 0.0582
Brugia malayi PAN domain containing protein 0.004 0.0301 0.0365
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0139 0.1545 0.1974
Brugia malayi steroid hormone receptor 0.0034 0.0224 0.0264
Onchocerca volvulus 0.0033 0.0214 0.0387
Echinococcus granulosus microtubule associated protein 2 0.0686 0.8479 1
Echinococcus multilocularis protein jagged 1 0.0029 0.0158 0.0158
Toxoplasma gondii microneme protein MIC17A 0.004 0.0301 0.0347
Brugia malayi Animal haem peroxidase family protein 0.0057 0.0515 0.0641
Echinococcus granulosus protein jagged 1 0.0029 0.0158 0.0186
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0089 0.009
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0322 0.0322
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.0806 0.0806
Brugia malayi Delta serrate ligand family protein 0.0029 0.0158 0.0179
Schistosoma mansoni hypothetical protein 0.0041 0.0303 0.0357
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0915 0.108
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0224 0.0264
Echinococcus multilocularis aryl hydrocarbon receptor 0.0281 0.3343 0.3343
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0214 0.0252
Echinococcus multilocularis peroxidasin 0.0057 0.0515 0.0515
Loa Loa (eye worm) heat shock protein 75 0.0029 0.0152 0.0196
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0019 0.0019
Mycobacterium ulcerans DNA gyrase subunit B 0.0027 0.0136 0.1229
Loa Loa (eye worm) hypothetical protein 0.0099 0.1038 0.134
Onchocerca volvulus 0.0067 0.0635 0.1686
Schistosoma mansoni heat shock protein 0.0083 0.0838 0.0988
Loa Loa (eye worm) hypothetical protein 0.0024 0.0089 0.0115
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0034 0.0218 0.067
Loa Loa (eye worm) TK/ROR protein kinase 0.0067 0.0635 0.082
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0081 0.0575
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0524 0.1787
Toxoplasma gondii heat shock protein 75, putative 0.0029 0.0152 0.0153
Echinococcus multilocularis transmembrane protease serine 3 0.0033 0.0214 0.0214
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.018 0.0213
Echinococcus multilocularis transfer RNA-Lys 0.0096 0.1008 0.1008
Schistosoma mansoni hypothetical protein 0.0029 0.0158 0.0186
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0245 0.0437
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0027 0.0136 0.0144
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0034 0.0218 0.067
Loa Loa (eye worm) hypothetical protein 0.0057 0.0515 0.0664
Schistosoma mansoni laminin gamma-3 chain 0.0029 0.0158 0.0186
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0249 0.2947 0.2947
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0201 0.026
Trypanosoma brucei glucose transporter, putative 0.0032 0.0194 0.0315
Onchocerca volvulus Putative cubilin 0.0029 0.0158 0.0212
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0034 0.0218 0.0408
Brugia malayi MAP kinase sur-1 0.0058 0.0524 0.0653
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0082 0.0831 0.1617
Echinococcus granulosus protein jagged 2 0.0029 0.0158 0.0186
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0152 0.018
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0019 0.0023
Echinococcus granulosus neuropeptide receptor A26 0.0461 0.5632 0.6643
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0224 0.0264
Plasmodium vivax endoplasmin, putative 0.0083 0.0838 0.1553
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0089 0.0759
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.1049 0.1237
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0035 0.0232 0.0232
Schistosoma mansoni DNA topoisomerase II 0.0027 0.0136 0.016
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0048 0.04 0.3888
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0027 0.0136 0.037
Echinococcus multilocularis tissue type plasminogen activator 0.0067 0.0635 0.0635
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Echinococcus granulosus tissue type plasminogen activator 0.0067 0.0635 0.0749
Schistosoma mansoni hypothetical protein 0.0029 0.0158 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0186 0.024
Loa Loa (eye worm) heat shock protein 90 0.0083 0.0838 0.1082
Echinococcus multilocularis mitogen activated protein kinase 11 0.014 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0025
Onchocerca volvulus 0.0057 0.0515 0.1314
Echinococcus granulosus General substrate transporter 0.0088 0.0908 0.1071
Plasmodium vivax hypothetical protein, conserved 0.0139 0.1545 0.2886
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Brugia malayi follicle stimulating hormone receptor 0.0227 0.2669 0.3429
Trypanosoma cruzi Heat shock protein 83, putative 0.0083 0.0838 0.163
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0027 0.0136 0.1837
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0214 0.0252
Onchocerca volvulus 0.0139 0.1545 0.4495
Echinococcus granulosus neuropeptide s receptor 0.0461 0.5632 0.6643
Leishmania major hypothetical protein, conserved 0.0418 0.5085 1
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0027 0.0136 0.2208
Loa Loa (eye worm) hypothetical protein 0.0122 0.1333 0.172
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0201 0.0237
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1091 0.1287
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0025
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0027 0.0136 0.016
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0037 0.0255 0.0482
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.0493 0.095
Echinococcus multilocularis jun protein 0.0091 0.0947 0.0947
Schistosoma mansoni hypothetical protein 0.0041 0.0303 0.0357
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1091 0.1287
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0246 0.2902 0.3729
Loa Loa (eye worm) hypothetical protein 0.0057 0.0515 0.0664
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0224 0.0264
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0029 0.0158 0.0186
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2773 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0515 0.0664
Trypanosoma brucei heat shock protein, putative 0.0083 0.0838 0.1591
Mycobacterium ulcerans chitinase/cellulase 0.0074 0.0733 0.7236
Loa Loa (eye worm) hypothetical protein 0.0033 0.0214 0.0276
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.018 0.1468
Brugia malayi Endochitinase 0.0098 0.1029 0.1307
Onchocerca volvulus 0.004 0.0301 0.0655
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0224 0.0264
Schistosoma mansoni hypothetical protein 0.0139 0.1545 0.1823
Schistosoma mansoni protein kinase 0.0032 0.0201 0.0237
Schistosoma mansoni microtubule-associated protein tau 0.0686 0.8479 1
Schistosoma mansoni calcium-activated potassium channel 0.0044 0.0345 0.0407
Schistosoma mansoni hypothetical protein 0.0169 0.1924 0.2269
Entamoeba histolytica protein kinase, putative 0.0032 0.0201 0.1676
Trypanosoma brucei protein kinase, putative 0.0058 0.0524 0.0969
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0089 0.0108
Loa Loa (eye worm) hypothetical protein 0.0057 0.0515 0.0664
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0224 0.0224
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.0515 0.0664
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0194 0.0315
Loa Loa (eye worm) PAN domain-containing protein 0.004 0.0301 0.0388
Trypanosoma cruzi hypothetical protein, conserved 0.0418 0.5085 1
Schistosoma mansoni transcription factor LCR-F1 0.008 0.0806 0.0951
Trypanosoma brucei heat shock protein, putative 0.0083 0.0838 0.1591
Mycobacterium ulcerans hypothetical protein 0.0048 0.04 0.3888
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0082 0.0831 0.1578
Echinococcus granulosus neural cadherin 0.0029 0.0158 0.0186
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0194 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0194 0.0582
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0017
Toxoplasma gondii hypothetical protein 0.004 0.0301 0.0347
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0025
Plasmodium falciparum heat shock protein 90, putative 0.0029 0.0152 0.0261
Trypanosoma brucei hypothetical protein, conserved 0.0418 0.5085 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0224 0.0416
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0255 0.222
Echinococcus multilocularis neurogenic locus protein delta 0.0029 0.0158 0.0158
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0524 0.0618
Brugia malayi Pre-SET motif family protein 0.0207 0.2411 0.3094
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0089 0.0547
Brugia malayi Sugar transporter family protein 0.0103 0.1091 0.1386
Echinococcus granulosus tumor protein p63 0.0386 0.4677 0.5516
Schistosoma mansoni hypothetical protein 0.0029 0.0158 0.0186
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0224 0.0416
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0524 0.1787
Onchocerca volvulus 0.0029 0.0158 0.0212
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0055 0.0493 0.6718
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0214 0.0252
Loa Loa (eye worm) hypothetical protein 0.0057 0.0515 0.0664
Echinococcus multilocularis calcium activated potassium channel variant 0.0044 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0051 0.0442 0.057
Onchocerca volvulus Putative endochitinase 0.0098 0.1029 0.2902
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0027 0.0136 0.1229
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0034 0.0047
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0019 0.0025
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0027 0.0136 0.1837
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0034 0.0044
Schistosoma mansoni glucose transport protein 0.0103 0.1091 0.1287
Loa Loa (eye worm) hypothetical protein 0.0033 0.0214 0.0276
Plasmodium falciparum heat shock protein 90 0.0083 0.0838 0.1553
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0214 0.0252
Mycobacterium tuberculosis Possible two component sensor kinase 0.0027 0.0136 0.1837
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0081 0.0092
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Trichomonas vaginalis sensor histidine kinase, putative 0.0027 0.0136 0.037
Brugia malayi Animal haem peroxidase family protein 0.0057 0.0515 0.0641
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0224 0.0264
Entamoeba histolytica hypothetical protein 0.008 0.0806 0.7754
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0224 0.0289
Loa Loa (eye worm) hypothetical protein 0.0033 0.0214 0.0276
Echinococcus multilocularis neurogenic locus notch protein 0.0029 0.0158 0.0158
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0224 0.0264
Brugia malayi EGF-like domain containing protein 0.0029 0.0158 0.0179
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0224 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0224 0.0264
Loa Loa (eye worm) hypothetical protein 0.0027 0.0136 0.0175
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0224 0.0264
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0089 0.0547
Entamoeba histolytica protein kinase, putative 0.0032 0.0201 0.1676
Trypanosoma cruzi heat shock protein 90, putative 0.0054 0.0477 0.0918
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0029 0.0152 0.0194
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0048 0.04 0.3888
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0194 0.036
Schistosoma mansoni hypothetical protein 0.0041 0.0303 0.0357
Toxoplasma gondii Hsp90 domain-containing protein 0.0029 0.0152 0.0153
Loa Loa (eye worm) hypothetical protein 0.0057 0.0515 0.0664
Brugia malayi Peroxidasin 0.0057 0.0515 0.0641
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0322 0.0416
Plasmodium vivax DNA gyrase subunit B, putative 0.0027 0.0136 0.023
Loa Loa (eye worm) hypothetical protein 0.004 0.0301 0.0388
Echinococcus granulosus neurogenic locus notch protein 0.0029 0.0158 0.0186
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0027 0.0136 0.1229
Loa Loa (eye worm) hypothetical protein 0.0033 0.0214 0.0276
Brugia malayi ecdysteroid receptor 0.0034 0.0224 0.0264
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0201 0.026
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0224 0.0264
Mycobacterium ulcerans heat shock protein 90 0.0055 0.0493 0.4821
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0136 0.023
Schistosoma mansoni pyruvate dehydrogenase 0.0222 0.2602 0.3069
Echinococcus multilocularis enteropeptidase 0.0033 0.0214 0.0214
Schistosoma mansoni pyruvate dehydrogenase 0.0249 0.2947 0.3476
Onchocerca volvulus 0.004 0.0301 0.0655
Brugia malayi Delta5 fatty acid desaturase 0.0099 0.1038 0.1318
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1293 0.1669
Echinococcus granulosus neurogenic locus notch protein 4 0.0029 0.0158 0.0186
Brugia malayi MH2 domain containing protein 0.0119 0.1293 0.1648
Brugia malayi endochitinase 0.0098 0.1029 0.1307
Mycobacterium leprae Probable two component sensor kinase MprB 0.0027 0.0136 0.2166
Echinococcus granulosus transmembrane protease serine 3 0.0033 0.0214 0.0252
Mycobacterium ulcerans hypothetical protein 0.0024 0.0089 0.0759
Schistosoma mansoni coup transcription factor 0.0034 0.0224 0.0264
Giardia lamblia High cysteine protein 0.0029 0.0158 0.1534
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0089 0.0108
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0033 0.0214 0.0252
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0029 0.0152 0.0179
Toxoplasma gondii microneme protein MIC4 0.004 0.0301 0.0347
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1562 0.1562
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0027 0.0136 0.2166
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0201 0.0354
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0034 0.0034
Toxoplasma gondii 1,3(4)-beta-glucanase 0.004 0.0301 0.0347
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0166 0.0171
Schistosoma mansoni patched 1 0.0042 0.0322 0.038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0017
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0224 0.0264
Entamoeba histolytica hypothetical protein 0.008 0.0806 0.7754
Brugia malayi small heat shock protein 0.0629 0.7749 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0136 0.0144
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0255 0.0807
Loa Loa (eye worm) trypsin family protein 0.0033 0.0214 0.0276
Toxoplasma gondii PAN domain-containing protein 0.0627 0.7725 1
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0027 0.0136 0.0151
Echinococcus granulosus single minded 2 0.0096 0.1008 0.1189
Echinococcus multilocularis slit 2 protein 0.0029 0.0158 0.0158
Trypanosoma brucei glucose transporter, putative 0.0032 0.0194 0.0315
Toxoplasma gondii microneme protein, putative 0.004 0.0301 0.0347
Echinococcus multilocularis fibropellin Ia 0.0029 0.0158 0.0158
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0214 0.0252
Leishmania major delta-5 fatty acid desaturase 0.0099 0.1038 0.1987
Giardia lamblia Heat shock protein HSP 90-alpha 0.0055 0.0493 0.5704
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0048 0.04 0.3888
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.014 0.1557 0.3047
Trypanosoma cruzi hexose transporter 0.0032 0.0194 0.036
Brugia malayi PAN domain containing protein 0.004 0.0301 0.0365
Plasmodium falciparum DNA gyrase subunit B 0.0027 0.0136 0.023
Loa Loa (eye worm) TOPoisomerase family member 0.0027 0.0136 0.0175
Onchocerca volvulus Slit protein homolog 0.0029 0.0158 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0224 0.0264
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0201 0.0354
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0255 0.0255
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0249 0.2947 0.5788
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Loa Loa (eye worm) hypothetical protein 0.028 0.3329 0.4296
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0201 0.0354
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0214 0.0252
Plasmodium falciparum protein kinase 7 0.0291 0.3477 0.6524
Schistosoma mansoni glucose transport protein 0.0103 0.1091 0.1287
Onchocerca volvulus Peroxidase homolog 0.0057 0.0515 0.1314
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0081 0.1223
Leishmania major protein kinase, putative 0.0037 0.0255 0.0438
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1562 0.1842
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1091 0.1091
Brugia malayi Animal haem peroxidase family protein 0.0057 0.0515 0.0641
Echinococcus multilocularis mitogen activated protein kinase 14 0.014 0.1557 0.1557
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0224 0.0264
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0048 0.04 0.0767
Schistosoma mansoni hypothetical protein 0.0041 0.0303 0.0357
Schistosoma mansoni septate junction protein 0.0029 0.0158 0.0186
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0089 0.114
Trichomonas vaginalis DNA topoisomerase II, putative 0.0027 0.0136 0.037
Brugia malayi Trypsin-like protease protein 5 0.0033 0.0214 0.0252
Loa Loa (eye worm) hypothetical protein 0.0057 0.0515 0.0664
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0224 0.0264
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0255 0.2433
Echinococcus multilocularis calcium activated potassium channel 0.005 0.0424 0.0424
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0214 0.0252
Mycobacterium tuberculosis Conserved protein 0.0048 0.04 0.545
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0089 0.0759
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.018 0.0213
Trypanosoma cruzi hypothetical protein, conserved 0.0418 0.5085 1
Mycobacterium ulcerans putative regultory protein 0.0027 0.0136 0.1229
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0224 0.0264
Echinococcus multilocularis fat cadherin tumor suppressor 0.0029 0.0158 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0224 0.0264
Trypanosoma brucei heat shock protein, putative 0.0083 0.0838 0.1591
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0224 0.0264
Toxoplasma gondii EGF family domain-containing protein 0.0029 0.0158 0.016
Schistosoma mansoni hypothetical protein 0.0029 0.0158 0.0186
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0194 0.0315
Giardia lamblia Pms1-like protein 0.0027 0.0136 0.1259
Onchocerca volvulus 0.004 0.0301 0.0655
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0224 0.0264
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0915 0.108
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0201 0.0354
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0201 0.0217
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0289
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0027 0.0136 0.02
Schistosoma mansoni peroxidasin 0.0057 0.0515 0.0607
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0201 0.0235
Brugia malayi Animal haem peroxidase family protein 0.0057 0.0515 0.0641
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0089 0.0759
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0249 0.2947 0.2947
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0136 0.0246
Plasmodium falciparum conserved protein, unknown function 0.0139 0.1545 0.2886
Onchocerca volvulus 0.0029 0.0158 0.0212
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0207 0.2807
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0037 0.0255 0.0482
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0164 0.0164
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0224 0.0224
Echinococcus multilocularis neural cadherin 0.0029 0.0158 0.0158
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0201 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0322 0.1051
Trypanosoma cruzi heat shock protein, putative 0.0029 0.0152 0.0278
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Plasmodium falciparum mitogen-activated protein kinase 2 0.0167 0.1905 0.3562
Echinococcus granulosus fibropellin Ia 0.0029 0.0158 0.0186
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0081 0.0095
Mycobacterium ulcerans hypothetical protein 0.0033 0.0214 0.2018
Leishmania major developmentally regulated phosphoprotein-like protein 0.0249 0.2947 0.5768
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0524 0.0969
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0034 0.002
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Loa Loa (eye worm) microfilarial chitinase 0.0085 0.0866 0.1118
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0322 0.038
Brugia malayi hypothetical protein 0.0122 0.1333 0.1699
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0245 0.0437
Toxoplasma gondii hypothetical protein 0.004 0.0301 0.0347
Schistosoma mansoni notch 0.0029 0.0158 0.0186
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0915 0.1181
Entamoeba histolytica hypothetical protein 0.008 0.0806 0.7754
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0214 0.0252
Plasmodium vivax heat shock protein, putative 0.0029 0.0152 0.0261
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0136 0.0246
Onchocerca volvulus 0.0034 0.0224 0.0416
Giardia lamblia Heat shock protein HSP 90-alpha 0.0083 0.0838 1
Echinococcus granulosus heat shock protein 90 0.0055 0.0493 0.0581
Onchocerca volvulus Dual oxidase homolog 0.0057 0.0515 0.1314
Toxoplasma gondii hypothetical protein 0.0139 0.1545 0.1965
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0136 0.0246
Brugia malayi PAS domain containing protein 0.013 0.1435 0.1832
Echinococcus granulosus aryl hydrocarbon receptor 0.0281 0.3343 0.3943
Chlamydia trachomatis DNA gyrase subunit B 0.0027 0.0136 0.2224
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0418 0.0516
Plasmodium vivax CDK-related protein kinase 6, putative 0.0437 0.5323 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0524 0.1011
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0139 0.1545 0.1545
Echinococcus granulosus notch 0.0029 0.0158 0.0186
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0136 0.02
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0048 0.04 0.0724
Loa Loa (eye worm) hypothetical protein 0.0057 0.0515 0.0664
Onchocerca volvulus Putative endochitinase 0.0098 0.1029 0.2902
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0089 0.0108
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0061 0.0563 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0255 0.0482
Trypanosoma brucei heat shock protein, putative 0.0083 0.0838 0.1591
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0194 0.0582
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0915 0.116
Onchocerca volvulus Huntingtin homolog 0.0122 0.1333 0.3839
Echinococcus multilocularis neurogenic locus notch protein 0.0029 0.0158 0.0158
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0029 0.0158 0.0212
Schistosoma mansoni pyruvate dehydrogenase 0.0222 0.2602 0.3069
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0129 0.142 0.142
Trypanosoma brucei heat shock protein 90, putative 0.0083 0.0838 0.1591
Schistosoma mansoni calcium-activated potassium channel 0.0047 0.0386 0.0456
Onchocerca volvulus 0.0056 0.0506 0.1286
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.103 0.1215
Loa Loa (eye worm) hypothetical protein 0.0024 0.0089 0.0115
Schistosoma mansoni hypothetical protein 0.0074 0.0731 0.0862
Loa Loa (eye worm) hypothetical protein 0.0074 0.0733 0.0946
Trypanosoma brucei glucose transporter, putative 0.0032 0.0194 0.0315
Loa Loa (eye worm) hypothetical protein 0.0057 0.0515 0.0664
Loa Loa (eye worm) endoplasmin 0.0083 0.0838 0.1082
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0224 0.0289
Leishmania major heat shock protein, putative 0.0029 0.0152 0.0232
Toxoplasma gondii heat shock protein 90, putative 0.0083 0.0838 0.1045
Leishmania major chitinase 0.0087 0.0896 0.1706
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0089 0.1198
Plasmodium falciparum heat shock protein 90, putative 0.0029 0.0152 0.0261
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Onchocerca volvulus 0.0029 0.0158 0.0212
Schistosoma mansoni single-minded 0.013 0.1435 0.1693
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0214 0.0252
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1091 0.1091
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0524 0.1011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.026
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0289
Echinococcus granulosus neurogenic locus protein delta 0.0029 0.0158 0.0186
Onchocerca volvulus 0.0097 0.1022 0.288
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0017
Schistosoma mansoni protein kinase 0.0032 0.0201 0.0237
Brugia malayi Calcium binding EGF domain containing protein 0.0029 0.0158 0.0179
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0166 0.0196
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.0515 0.0664
Loa Loa (eye worm) FAT-3 protein 0.0099 0.1038 0.134
Loa Loa (eye worm) hypothetical protein 0.0056 0.0506 0.0652
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.018 0.1818
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0524 0.0969
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0027 0.0136 0.2166
Loa Loa (eye worm) hypothetical protein 0.0139 0.1545 0.1994
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0255 0.0482
Loa Loa (eye worm) hypothetical protein 0.0629 0.7749 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0166 0.0196
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0034 0.0218 0.0363
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0289
Mycobacterium tuberculosis Probable two component sensor kinase 0.0027 0.0136 0.1837
Trypanosoma brucei glucose transporter, putative 0.0032 0.0194 0.0315
Mycobacterium ulcerans chitinase/cellulase 0.0074 0.0733 0.7236
Echinococcus multilocularis neurogenic locus notch protein 4 0.0029 0.0158 0.0158
Onchocerca volvulus 0.004 0.0301 0.0655
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0037 0.0255 0.0482
Echinococcus multilocularis protein patched 0.0042 0.0322 0.0322
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0214 0.0252
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Trichomonas vaginalis guanylate cyclase, putative 0.0034 0.0218 0.067
Plasmodium falciparum protein kinase 6 0.0437 0.5323 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0136 0.0132
Loa Loa (eye worm) hypothetical protein 0.0089 0.0913 0.1179
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0201 0.0237
Schistosoma mansoni notch 0.0029 0.0158 0.0186
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0027 0.0136 0.1837
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0224 0.0264
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.018 0.0534
Echinococcus multilocularis protein jagged 1 0.0029 0.0158 0.0158
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0027 0.0136 0.0136
Trichomonas vaginalis guanylate cyclase, putative 0.0034 0.0218 0.067
Brugia malayi EGF-like domain containing protein 0.0029 0.0158 0.0179
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.014 0.1557 0.3014
Brugia malayi P38 map kinase family protein 2 0.014 0.1557 0.1989
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0915 0.0915
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0136 0.0144
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0027 0.0136 0.1229
Loa Loa (eye worm) hypothetical protein 0.0033 0.0214 0.0276
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0255 0.0807
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0224 0.0264
Toxoplasma gondii heat shock protein HSP90 0.0083 0.0838 0.1045
Brugia malayi PAN domain containing protein 0.004 0.0301 0.0365
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0194 0.036
Echinococcus multilocularis potassium large conductance calcium activated 0.0047 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Toxoplasma gondii PAN domain-containing protein 0.004 0.0301 0.0347
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0224 0.0264
Echinococcus granulosus heat shock protein 0.0083 0.0838 0.0988
Loa Loa (eye worm) hypothetical protein 0.0024 0.0089 0.0115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0224 0.0264
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0013 0.0166
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0027 0.0136 0.1837
Onchocerca volvulus Putative endochitinase 0.0087 0.0896 0.249
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0034 0.0218 0.067
Trichomonas vaginalis heat shock protein, putative 0.0056 0.0497 0.169
Brugia malayi Trypsin family protein 0.0033 0.0214 0.0252
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0214 0.0214
Trypanosoma brucei heat shock protein, putative 0.0083 0.0838 0.1591
Loa Loa (eye worm) hypothetical protein 0.004 0.0301 0.0388
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0027 0.0136 0.1229
Brugia malayi Calcium binding EGF domain containing protein 0.0029 0.0158 0.0179
Brugia malayi Cam kinase protein 1 0.0032 0.0201 0.0235
Trypanosoma brucei heat shock protein, putative 0.0083 0.0838 0.1591
Plasmodium vivax DNA topoisomerase II, putative 0.0027 0.0136 0.023
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.103 0.103
Brugia malayi PAN domain containing protein 0.004 0.0301 0.0365
Mycobacterium ulcerans putative regulatory protein 0.0096 0.1008 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0224 0.0264
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0089 0.114
Onchocerca volvulus Putative endochitinase 0.0087 0.0896 0.249
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0082 0.0831 0.1036
Brugia malayi Trypsin family protein 0.0033 0.0214 0.0252
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0089 0.0547
Echinococcus multilocularis geminin 0.0169 0.1924 0.1924
Brugia malayi heat shock protein 90 0.0083 0.0838 0.1059
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0214 0.0252
Onchocerca volvulus 0.0029 0.0158 0.0212
Echinococcus granulosus jun protein 0.0091 0.0947 0.1117
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0194 0.0315
Loa Loa (eye worm) hypothetical protein 0.0034 0.0219 0.0283
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0524 0.0676
Brugia malayi hypothetical protein 0.0072 0.0699 0.0879
Brugia malayi nuclear hormone receptor 0.0034 0.0224 0.0264
Brugia malayi bHLH-PAS transcription factor 0.0096 0.1008 0.1279
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0524 0.0636
Plasmodium vivax hexose transporter 0.0103 0.1091 0.2029
Brugia malayi EGF-like domain containing protein 0.0029 0.0158 0.0179
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0136 0.0132
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0136 0.0246
Plasmodium falciparum hexose transporter 0.0103 0.1091 0.2029
Onchocerca volvulus 0.0057 0.0515 0.1314
Loa Loa (eye worm) notch protein 0.0029 0.0158 0.0203
Entamoeba histolytica DNA topoisomerase II, putative 0.0027 0.0136 0.1017
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0506 0.0596
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0194 0.0315
Trypanosoma brucei glucose transporter 1E 0.0032 0.0194 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0218 0.067
Echinococcus granulosus calcium activated potassium channel 0.005 0.0424 0.05
Brugia malayi hypothetical protein 0.0034 0.0218 0.0257
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0033 0.0214 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0218 0.067
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0081 0.0676
Mycobacterium ulcerans two component regulator - sensor kinase 0.0027 0.0136 0.1229
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.0515 0.0664
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0091 0.0947 0.1117
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0194 0.0582
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0524 0.0618
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0027 0.0136 0.1837
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0255 0.482
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0055 0.0493 0.0908
Onchocerca volvulus Huntingtin homolog 0.0122 0.1333 0.3839
Leishmania major glucose transporter, lmgt2 0.0032 0.0194 0.0315
Mycobacterium leprae Possible regulatory protein 0.0034 0.0218 0.3969
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.2669 0.3445
Brugia malayi notch-like transmembrane receptor 0.0029 0.0158 0.0179
Mycobacterium tuberculosis Possible chitinase 0.0074 0.0733 1
Schistosoma mansoni hypothetical protein 0.0034 0.0219 0.0259
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0224 0.0289
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0224 0.0264
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0027 0.0136 0.037
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0027 0.0136 0.1229
Brugia malayi Cadherin domain containing protein 0.0029 0.0158 0.0179
Trypanosoma brucei heat shock protein 84, putative 0.0029 0.0152 0.0232
Brugia malayi PAN domain containing protein 0.004 0.0301 0.0365
Echinococcus granulosus Mastin 0.0033 0.0214 0.0252
Brugia malayi Cadherin domain containing protein 0.0029 0.0158 0.0179
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0081 0.0092
Loa Loa (eye worm) hypothetical protein 0.0027 0.0136 0.0175
Trypanosoma brucei heat shock protein 90, putative 0.0083 0.0838 0.1591
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0218 0.067
Schistosoma mansoni hypothetical protein 0.0029 0.0158 0.0186
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0224 0.0224
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0255 0.0301
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0224 0.0224
Toxoplasma gondii protein kinase, putative 0.0291 0.3477 0.4477
Echinococcus granulosus potassium large conductance calcium activated 0.0047 0.0386 0.0456
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1091 0.1287
Brugia malayi GCC2 and GCC3 family protein 0.0029 0.0158 0.0179
Onchocerca volvulus 0.0072 0.0699 0.1883
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0214 0.0252
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0055 0.0493 0.0581
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0201 0.033
Brugia malayi Protein kinase domain containing protein 0.0067 0.0635 0.0797
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Toxoplasma gondii kringle domain-containing protein 0.0067 0.0635 0.0781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0915 0.108
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0224 0.0264
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.014 0.1557 0.3014
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0201 0.0354
Toxoplasma gondii microneme protein MIC17B 0.004 0.0301 0.0347
Schistosoma mansoni ap endonuclease 0.0019 0.0034 0.0041
Onchocerca volvulus 0.004 0.0301 0.0655
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.0233
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0194 0.0582
Schistosoma mansoni notch 0.0029 0.0159 0.0188
Echinococcus granulosus protein jagged 2 0.0029 0.0158 0.0186
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0224 0.0224
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0219 0.0259
Loa Loa (eye worm) inositol-1 0.0037 0.0255 0.033
Echinococcus multilocularis heat shock protein 90 0.0083 0.0838 0.0838
Trypanosoma brucei Heat shock protein 83, putative 0.0083 0.0838 0.1591
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.1091 0.3858
Toxoplasma gondii PAN/Apple domain-containing protein 0.004 0.0301 0.0347
Brugia malayi CHE-14 protein 0.0042 0.0322 0.0392
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0322 0.038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0224 0.0264
Schistosoma mansoni aryl hydrocarbon receptor 0.0377 0.4561 0.5379
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0245 0.0462
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0027 0.0136 0.2208
Echinococcus granulosus endoplasmin 0.0055 0.0493 0.0581
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0201 0.0354
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0027 0.0136 0.1837
Brugia malayi Trypsin family protein 0.0033 0.0214 0.0252
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0017
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0034 0.0041
Echinococcus granulosus heat shock protein 90 0.0083 0.0838 0.0988
Trypanosoma brucei heat shock protein, putative 0.0083 0.0838 0.1591
Trypanosoma cruzi heat shock protein 85, putative 0.0083 0.0838 0.163
Brugia malayi Endoplasmin precursor 0.0083 0.0838 0.1059
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0019 0.0023
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0034 0.0454
Loa Loa (eye worm) MaxiK calcium-activated potassium channel 0.0031 0.0186 0.024
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0027 0.0136 0.037
Leishmania major glucose transporter, lmgt3 0.0032 0.0194 0.0315
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0201 0.0237
Loa Loa (eye worm) hypothetical protein 0.0034 0.0218 0.0281
Onchocerca volvulus Peroxidasin homolog 0.0057 0.0515 0.1314
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0139 0.1545 0.1823
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0034 0.0218 0.0408
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0166 0.0166
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0214 0.0252
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0201 0.0354
Loa Loa (eye worm) hypothetical protein 0.0057 0.0515 0.0664
Echinococcus multilocularis heat shock protein 0.0083 0.0838 0.0838
Treponema pallidum heat shock protein 90 0.0055 0.0493 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0037 0.0487
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0034 0.0218 0.067
Echinococcus multilocularis citrate lyase subunit beta protein 0.0048 0.04 0.04
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0201 0.0354
Toxoplasma gondii PAN domain-containing protein 0.0627 0.7725 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0025
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Brugia malayi PAN domain containing protein 0.004 0.0301 0.0365
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0224 0.0224
Leishmania major hypothetical protein, conserved 0.0027 0.0136 0.02
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0224 0.0264
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0109 0.1176 0.1485
Schistosoma mansoni hypothetical protein 0.008 0.0806 0.0951
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0201 0.0354
Brugia malayi bZIP transcription factor family protein 0.0091 0.0947 0.1201
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0027 0.0136 0.037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0224 0.0264
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Loa Loa (eye worm) hypothetical protein 0.0057 0.0515 0.0664
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.1091 0.1287
Plasmodium vivax heat shock protein 90, putative 0.0029 0.0152 0.0261
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0089 0.0759
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0166 0.0196
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0214 0.0252
Onchocerca volvulus 0.0099 0.1042 0.2942
Schistosoma mansoni endoplasmin 0.0083 0.0838 0.0988
Echinococcus multilocularis mitogen activated protein kinase 11 0.014 0.1557 0.1557
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0147 0.1649 0.1945
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.018 0.018
Echinococcus granulosus calcium activated potassium channel variant 0.0044 0.0345 0.0407
Brugia malayi Muscle positioning protein 4 0.0029 0.0158 0.0179
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.014 0.1557 0.3047
Chlamydia trachomatis DNA gyrase subunit B 0.0027 0.0136 0.2224
Plasmodium vivax heat shock protein 86, putative 0.0083 0.0838 0.1553
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0166 0.0196
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.018 0.315
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0031 0.0186 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0224 0.0264
Onchocerca volvulus 0.0033 0.0214 0.0387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0166 0.0196
Echinococcus multilocularis expressed conserved protein 0.0092 0.0955 0.0955
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0224 0.0289
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0037 0.0255 0.0482
Schistosoma mansoni slit 0.0029 0.0158 0.0186
Trichomonas vaginalis endoplasmin, putative 0.0056 0.0497 0.169
Echinococcus multilocularis protein dispatched 1 0.0048 0.0397 0.0397
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0082 0.0831 0.1578
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1293 0.1669
Onchocerca volvulus 0.004 0.0301 0.0655
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0214 0.0252
Trypanosoma brucei DNA topoisomerase ii 0.0027 0.0136 0.02
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0289
Loa Loa (eye worm) sugar transporter 0.0103 0.1091 0.1408
Loa Loa (eye worm) hypothetical protein 0.004 0.0301 0.0388
Loa Loa (eye worm) hypothetical protein 0.0023 0.0081 0.0104
Onchocerca volvulus 0.0033 0.0214 0.0387
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0224 0.0264
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0224 0.0264
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0289
Schistosoma mansoni heat shock protein 0.0029 0.0152 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0224 0.0264
Loa Loa (eye worm) hypothetical protein 0.0249 0.2947 0.3804
Trypanosoma cruzi heat shock protein 90, putative 0.0083 0.0838 0.163
Echinococcus multilocularis microtubule associated protein 2 0.0686 0.8479 0.8479
Loa Loa (eye worm) hypothetical protein 0.0057 0.0515 0.0664
Onchocerca volvulus Neurogenic locus notch homolog 0.0029 0.0159 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0201 0.0237
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0136 0.0246
Echinococcus multilocularis mitogen activated protein kinase 14 0.014 0.1557 0.1557
Echinococcus granulosus geminin 0.0169 0.1924 0.2269
Schistosoma mansoni ap endonuclease 0.0019 0.0034 0.0041
Onchocerca volvulus Peroxidase homolog 0.0057 0.0515 0.1314
Loa Loa (eye worm) hypothetical protein 0.0247 0.2916 0.3763
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0524 0.0524
Brugia malayi Blistered cuticle protein 3 0.0057 0.0515 0.0641
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.0806 0.0951
Echinococcus granulosus mitogen activated protein kinase 11 0.014 0.1557 0.1836
Trichomonas vaginalis heat shock protein, putative 0.0055 0.0493 0.1674
Toxoplasma gondii PAN domain-containing protein 0.004 0.0301 0.0347
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0152 0.0429
Echinococcus multilocularis neuropeptide s receptor 0.0461 0.5632 0.5632
Brugia malayi Hsp90 protein 0.0029 0.0152 0.0171
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0224 0.0264
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0915 0.0915
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0029 0.0158 0.0179
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0214 0.0252
Brugia malayi nuclear receptor NHR-88 0.0034 0.0224 0.0264
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0055 0.0493 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0245 0.0417
Onchocerca volvulus 0.004 0.0301 0.0655
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0035 0.0232 0.0299
Echinococcus granulosus neurogenic locus notch protein 0.0029 0.0158 0.0186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0224 0.0289
Mycobacterium ulcerans two component sensor kinase MprB 0.0027 0.0136 0.1229
Loa Loa (eye worm) hypothetical protein 0.004 0.0301 0.0388
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0289
Plasmodium vivax SET domain protein, putative 0.003 0.0166 0.0288
Entamoeba histolytica heat shock protein 90, putative 0.0083 0.0838 0.8073
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.1091 0.1374
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0224 0.0224
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0255 0.0287
Loa Loa (eye worm) hypothetical protein 0.003 0.0166 0.0214
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0048 0.04 0.0767
Entamoeba histolytica hypothetical protein 0.008 0.0806 0.7754
Loa Loa (eye worm) hypothetical protein 0.0042 0.0322 0.0416
Loa Loa (eye worm) hypothetical protein 0.0057 0.0515 0.0664
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0081 0.0127
Schistosoma mansoni notch 0.0029 0.0158 0.0186
Loa Loa (eye worm) hypothetical protein 0.0033 0.0214 0.0276
Echinococcus multilocularis neuropeptide receptor A26 0.0461 0.5632 0.5632
Echinococcus multilocularis protein jagged 2 0.0029 0.0158 0.0158
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0033 0.0214 0.0252
Giardia lamblia Grp94/Hsp90 0.0055 0.0493 0.5704
Echinococcus granulosus expressed conserved protein 0.0092 0.0955 0.1126
Mycobacterium ulcerans hypothetical protein 0.0048 0.04 0.3888
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0255 0.0438
Schistosoma mansoni hypothetical protein 0.0029 0.0158 0.0186
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0027 0.0136 0.02
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0224 0.0264
Brugia malayi PAN domain containing protein 0.004 0.0301 0.0365
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Schistosoma mansoni protein kinase 0.0032 0.0201 0.0237
Brugia malayi endochitinase 0.0087 0.0896 0.1134
Loa Loa (eye worm) Notch2 0.0029 0.0158 0.0203
Onchocerca volvulus 0.0057 0.0515 0.1314
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0089 0.009
Leishmania major protein kinase, putative 0.0037 0.0255 0.0438
Leishmania major DNA topoisomerase ii 0.0027 0.0136 0.02
Entamoeba histolytica hypothetical protein 0.0023 0.0081 0.0464
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0034 0.0211
Echinococcus multilocularis Mastin 0.0033 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0089 0.0916 0.1182
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0027 0.0136 0.1837
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0027 0.0136 0.1837
Schistosoma mansoni hypothetical protein 0.0033 0.0214 0.0252
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0245 0.0274
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.1091 0.1091
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0081 0.0676
Entamoeba histolytica heat shock protein 90, putative 0.0083 0.0838 0.8073
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0214 0.0252
Plasmodium falciparum DNA topoisomerase 2 0.0027 0.0136 0.023
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0224 0.0416
Echinococcus multilocularis glycoprotein Antigen 5 0.0033 0.0214 0.0214
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0033 0.0214 0.0252
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0025
Echinococcus multilocularis tumor protein p63 0.0386 0.4677 0.4677
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0194 0.036
Brugia malayi Probable DNA topoisomerase II 0.0027 0.0136 0.0151
Loa Loa (eye worm) hypothetical protein 0.0067 0.0635 0.082
Onchocerca volvulus 0.003 0.0166 0.0239
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0214 0.0252
Onchocerca volvulus Peroxidasin homolog 0.0057 0.0515 0.1314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0224 0.0289
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0029 0.0152 0.1179
Echinococcus granulosus slit 2 protein 0.0029 0.0158 0.0186
Onchocerca volvulus 0.0236 0.2774 0.8288
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0418 0.0516
Brugia malayi PAN domain containing protein 0.004 0.0301 0.0365
Loa Loa (eye worm) hypothetical protein 0.0057 0.0515 0.0664
Trypanosoma brucei glucose transporter, putative 0.0032 0.0194 0.0315
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0524 0.0969
Loa Loa (eye worm) hypothetical protein 0.005 0.0418 0.0539
Loa Loa (eye worm) cuticular endochitinase 0.0087 0.0896 0.1156
Brugia malayi EGF-like domain containing protein 0.0029 0.0158 0.0179
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0224 0.0224
Entamoeba histolytica chitinase, putative 0.0087 0.0896 0.8653
Plasmodium falciparum cysteine repeat modular protein 1 0.0067 0.0635 0.1171
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0027 0.0136 0.1837
Loa Loa (eye worm) hypothetical protein 0.0139 0.1545 0.1994
Brugia malayi Pre-SET motif family protein 0.003 0.0166 0.019
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0081 0.0169
Trypanosoma brucei glucose transporter, putative 0.0032 0.0194 0.0315
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0255 0.0807
Loa Loa (eye worm) hypothetical protein 0.0033 0.0214 0.0276
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0091 0.0947 0.0947
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0027 0.0136 0.1229
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0027 0.0136 0.1837
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0255 0.0438
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.014 0.1557 0.2009
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0029 0.0152 0.0152
Brugia malayi EGF-like domain containing protein 0.0029 0.0158 0.0179
Onchocerca volvulus 0.028 0.3329 1
Brugia malayi Protein kinase domain containing protein 0.0019 0.0036 0.0021
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0524 0.6087
Schistosoma mansoni hypothetical protein 0.0067 0.0635 0.0749
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0027 0.0136 0.023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Toxoplasma gondii PAN domain-containing protein 0.004 0.0301 0.0347
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0034 0.004
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0245 0.0417
Mycobacterium tuberculosis Conserved protein 0.0027 0.0136 0.1837
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0201 0.0237
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0034 0.004
Schistosoma mansoni retinoic acid receptor RXR 0.0147 0.1649 0.1945
Echinococcus multilocularis General substrate transporter 0.0088 0.0908 0.0908
Schistosoma mansoni notch 0.0029 0.0158 0.0186
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0524 0.1011
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0081 0.0095
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0224 0.0289
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0089 0.0759
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0915 0.108
Echinococcus granulosus peroxidasin 0.0057 0.0515 0.0607
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0245 0.0462
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2411 0.3111
Schistosoma mansoni inositol monophosphatase 0.0037 0.0255 0.0301
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0027 0.0136 0.2208
Schistosoma mansoni hypothetical protein 0.0029 0.0158 0.0186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0915 0.108
Echinococcus granulosus glycoprotein Antigen 5 0.0033 0.0214 0.0252
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0164 0.0193
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0081 0.096
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0524 0.0618
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0037 0.0487
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0089 0.0759
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0201 0.0217
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0524 0.1787
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0027 0.0136 0.1229
Schistosoma mansoni endoplasmin 0.0083 0.0838 0.0988
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0048 0.04 0.545
Echinococcus granulosus mitogen activated protein kinase 14 0.014 0.1557 0.1836
Leishmania major protein kinase, putative 0.0032 0.0201 0.033
Brugia malayi hypothetical protein 0.008 0.0806 0.1018
Schistosoma mansoni fatty acid desaturase 0.0099 0.1042 0.1229
Loa Loa (eye worm) hypothetical protein 0.0246 0.2902 0.3745
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0033 0.0214 0.0214
Schistosoma mansoni hypothetical protein 0.0103 0.1091 0.1287
Schistosoma mansoni cell polarity protein 0.0029 0.0158 0.0186
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.103 0.1308
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0167 0.1905 0.2432
Brugia malayi kinase, mitochondrial precursor 0.0249 0.2947 0.3788
Loa Loa (eye worm) hypothetical protein 0.0098 0.103 0.1329
Loa Loa (eye worm) PAN domain-containing protein 0.004 0.0301 0.0388
Trypanosoma brucei glucose transporter, putative 0.0032 0.0194 0.0315
Brugia malayi EGF-like domain containing protein 0.0029 0.0158 0.0179
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0289
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0524 0.1787
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.0233
Onchocerca volvulus 0.0139 0.1545 0.4495
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0201 0.0201
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0167 0.1905 0.3562
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0035 0.0232 0.0274
Trypanosoma cruzi heat shock protein 90, putative 0.0055 0.0493 0.095
Onchocerca volvulus 0.0033 0.0214 0.0387
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0027 0.0136 0.2208
Leishmania major hypothetical protein, conserved 0.0067 0.0635 0.119
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0027 0.0136 0.2208
Schistosoma mansoni jun-related protein 0.0074 0.0731 0.0862
Onchocerca volvulus Chorion peroxidase homolog 0.0057 0.0515 0.1314
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.0515 0.0664
Loa Loa (eye worm) hypothetical protein 0.0122 0.1333 0.172
Schistosoma mansoni peroxidasin 0.0057 0.0515 0.0607
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0224 0.0289
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0034 0.0047
Toxoplasma gondii PAN domain-containing protein 0.004 0.0301 0.0347
Brugia malayi PAN domain containing protein 0.004 0.0301 0.0365
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Brugia malayi hypothetical protein 0.0057 0.0515 0.0641
Onchocerca volvulus 0.0033 0.0214 0.0387
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0081 0.0138
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0027 0.0136 0.1837
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.018 0.0209
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0044 0.0345 0.0445
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0081 0.0081
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0081 0.006
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0027 0.0136 0.037
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0027 0.0136 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0224 0.0264
Echinococcus multilocularis notch 0.0029 0.0158 0.0158
Loa Loa (eye worm) PAN domain-containing protein 0.004 0.0301 0.0388
Trichomonas vaginalis adenylate cyclase, putative 0.0034 0.0218 0.067
Schistosoma mansoni inositol monophosphatase 0.0037 0.0255 0.0301
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0635 0.1231
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0418 0.0539
Echinococcus granulosus enteropeptidase 0.0033 0.0214 0.0252
Loa Loa (eye worm) PAN domain-containing protein 0.004 0.0301 0.0388
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0089 0.009
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0245 0.0417
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0084 0.0855 0.0855
Brugia malayi EGF-like domain containing protein 0.0029 0.0158 0.0179
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0055 0.0493 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0301 0.0388
Brugia malayi Kringle domain containing protein 0.0067 0.0635 0.0797
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0045 0.0038
Loa Loa (eye worm) hypothetical protein 0.004 0.0301 0.0388
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0524 0.1011
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.103 1
Onchocerca volvulus 0.004 0.0301 0.0655
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0524 0.0524
Echinococcus multilocularis heat shock protein 90 0.0055 0.0493 0.0493
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0207 0.3723
Leishmania major heat shock protein 83-1 0.0083 0.0838 0.1591
Trichomonas vaginalis heat shock protein, putative 0.0055 0.0493 0.1674
Schistosoma mansoni hypothetical protein 0.0033 0.0214 0.0252
Onchocerca volvulus 0.0033 0.0214 0.0387
Trypanosoma cruzi heat shock protein 85, putative 0.0083 0.0838 0.163
Onchocerca volvulus 0.0029 0.0158 0.0212
Trichomonas vaginalis heat shock protein, putative 0.0083 0.0838 0.2935
Echinococcus granulosus nuclear factor of activated T cells 5 0.0084 0.0855 0.1009
Brugia malayi Calcium binding EGF domain containing protein 0.0029 0.0158 0.0179
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0166 0.0166
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0034 0.0218 0.067
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0249 0.2947 0.3476
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0027 0.0136 0.1229
Loa Loa (eye worm) PAN domain-containing protein 0.004 0.0301 0.0388
Leishmania major glucose transporter, lmgt1 0.0032 0.0194 0.0315
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0081 0.0095
Brugia malayi Animal haem peroxidase family protein 0.0057 0.0515 0.0641
Brugia malayi hypothetical protein 0.0033 0.0214 0.0252
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0067 0.0635 0.1171
Onchocerca volvulus 0.004 0.0301 0.0655
Trypanosoma brucei heat shock protein, putative 0.0083 0.0838 0.1591
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0081 0.0127
Echinococcus multilocularis endoplasmin 0.0055 0.0493 0.0493
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0081 0.0079
Schistosoma mansoni glucose transport protein 0.0103 0.1091 0.1287
Toxoplasma gondii subtilisin SUB12 0.004 0.0301 0.0347
Toxoplasma gondii DNA topoisomerase 2, putative 0.0027 0.0136 0.0132
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0201 0.0217
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Leishmania major mitochondrial DNA topoisomerase II 0.0027 0.0136 0.02
Trypanosoma brucei glucose transporter, putative 0.0032 0.0194 0.0315
Echinococcus granulosus citrate lyase subunit beta protein 0.0048 0.04 0.0472
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0201 0.0609
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Onchocerca volvulus 0.004 0.0301 0.0655
Brugia malayi PAN domain containing protein 0.004 0.0301 0.0365
Plasmodium falciparum endoplasmin, putative 0.0056 0.0497 0.0911
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0201 0.0201
Toxoplasma gondii microneme protein MIC17C 0.004 0.0301 0.0347
Echinococcus granulosus delta-like protein 1 0.0029 0.0158 0.0186
Echinococcus granulosus protein jagged 1 0.0029 0.0158 0.0186
Trypanosoma brucei developmentally regulated phosphoprotein 0.0249 0.2947 0.5768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0089 0.1198
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.018 0.0209
Schistosoma mansoni notch 0.0029 0.0158 0.0186
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0224 0.0264
Brugia malayi Inositol-1 0.0037 0.0255 0.0305
Loa Loa (eye worm) blistered cuticle protein 3 0.0057 0.0515 0.0664
Loa Loa (eye worm) chitinase I 0.0087 0.0896 0.1156
Brugia malayi Trypsin family protein 0.0033 0.0214 0.0252
Trypanosoma cruzi heat shock protein 85, putative 0.0083 0.0838 0.163
Trypanosoma brucei glucose transporter 2A 0.0032 0.0194 0.0315
Echinococcus multilocularis neurogenic locus protein delta 0.0029 0.0158 0.0158
Trichomonas vaginalis heat shock protein, putative 0.0055 0.0493 0.1674
Loa Loa (eye worm) hypothetical protein 0.004 0.0301 0.0388
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0203
Onchocerca volvulus Putative endochitinase 0.0098 0.1029 0.2902
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0194 0.0582
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.018 0.0213
Onchocerca volvulus 0.004 0.0301 0.0655
Trichomonas vaginalis receptor histidine kinase, putative 0.0027 0.0136 0.037
Mycobacterium leprae Probable two-component sensor kinase 0.0027 0.0136 0.2166
Schistosoma mansoni heat shock protein 0.0083 0.0838 0.0988
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.1091 0.1091

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 36.6 uM Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay ChEMBL. 25088398

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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