Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | oxidoreductase | 0.012 | 0.0546 | 0.6031 |
Echinococcus multilocularis | geminin | 0.0172 | 0.0874 | 0.1864 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0012 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0055 | 0.0131 | 0.0722 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0012 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0055 | 0.0131 | 0.0946 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0055 | 0.0131 | 0.0946 |
Echinococcus granulosus | neuropeptide s receptor | 0.0478 | 0.2826 | 0.609 |
Schistosoma mansoni | gabp alpha | 0.0071 | 0.0229 | 0.0256 |
Onchocerca volvulus | 0.0146 | 0.0709 | 0.4054 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0055 | 0.0131 | 0.0722 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0175 | 0.0896 | 1 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0055 | 0.0131 | 0.0722 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0102 | 0.022 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0055 | 0.0131 | 0.0946 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0387 | 0.2242 | 0.4841 |
Schistosoma mansoni | ets-related | 0.0214 | 0.1144 | 0.1276 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0101 | 0.0541 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0478 | 0.2826 | 0.609 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0175 | 0.0896 | 0.706 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0055 | 0.0131 | 0.134 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0055 | 0.0131 | 0.0946 |
Loa Loa (eye worm) | cytochrome P450 | 0.0055 | 0.0131 | 0.0283 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0102 | 0.022 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0175 | 0.0896 | 0.706 |
Brugia malayi | Cytochrome P450 family protein | 0.0055 | 0.0131 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0012 | 0.0027 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0012 | 0.0027 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0071 | 0.0229 | 0.0469 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0012 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0175 | 0.0896 | 1 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0175 | 0.0896 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0055 | 0.0131 | 0.0946 |
Brugia malayi | Cytochrome P450 family protein | 0.0055 | 0.0131 | 0.0283 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0012 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0055 | 0.0131 | 0.0283 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0041 | 0.0044 | 0.0189 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0478 | 0.2826 | 0.609 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0055 | 0.0131 | 0.134 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0055 | 0.0131 | 0.0283 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0012 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0055 | 0.0131 | 0.0946 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.0229 | 0.0495 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0175 | 0.0896 | 0.706 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.0551 | 0.1189 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0012 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0012 | 0.0027 |
Leishmania major | cytochrome p450-like protein | 0.0055 | 0.0131 | 0.0722 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0175 | 0.0896 | 0.706 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0012 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0164 | 0.0354 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.0551 | 0.1189 |
Echinococcus granulosus | geminin | 0.0172 | 0.0874 | 0.1864 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0175 | 0.0896 | 1 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0055 | 0.0131 | 0.134 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0762 | 0.4632 | 1 |
Brugia malayi | hypothetical protein | 0.0306 | 0.1731 | 0.3736 |
Leishmania major | cytochrome p450-like protein | 0.0055 | 0.0131 | 0.0722 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0175 | 0.0896 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0012 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0175 | 0.0896 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0055 | 0.0131 | 0.0256 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0375 | 0.217 | 0.4684 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0012 | 0.0027 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0175 | 0.0896 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0055 | 0.0131 | 0.0722 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0012 | 0.0027 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.0874 | 0.0974 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.0551 | 0.1189 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0012 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0.0082 | 0.007 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.0667 | 0.3987 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0071 | 0.0229 | 0.0469 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0055 | 0.0131 | 0.0722 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0012 | 0.0027 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0055 | 0.0131 | 0.0946 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0175 | 0.0896 | 0.706 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0175 | 0.0896 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.012 | 0.0546 | 0.4258 |
Echinococcus multilocularis | 0.0055 | 0.0131 | 0.0256 | |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0131 | 0.0146 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0055 | 0.0131 | 0.0946 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0175 | 0.0896 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0055 | 0.0131 | 0.0146 |
Brugia malayi | Cytochrome P450 family protein | 0.0055 | 0.0131 | 0.0283 |
Trypanosoma brucei | cytochrome P450, putative | 0.0055 | 0.0131 | 0.0722 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0175 | 0.0896 | 0.706 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0055 | 0.0131 | 0.0283 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0071 | 0.0229 | 0.0495 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.0667 | 0.3987 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0041 | 0.0044 | 0.0189 |
Brugia malayi | DOMON domain containing protein | 0.0146 | 0.0709 | 0.1531 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0055 | 0.0131 | 0.134 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.0874 | 0.0974 |
Brugia malayi | DOMON domain containing protein | 0.0146 | 0.0709 | 0.1531 |
Brugia malayi | DOMON domain containing protein | 0.0146 | 0.0709 | 0.1531 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0762 | 0.4632 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0012 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0102 | 0.022 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0012 | 0.0027 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.1443 | 0.8967 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0155 | 0.0767 | 0.8535 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0012 | 0.0027 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0294 | 0.1654 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0294 | 0.1654 | 1 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0175 | 0.0896 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0175 | 0.0896 | 0.706 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0146 | 0.0709 | 0.1531 |
Onchocerca volvulus | 0.0146 | 0.0709 | 0.4054 | |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0175 | 0.0896 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0294 | 0.1654 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0012 | 0.0027 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0139 | 0.0667 | 0.3987 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0233 | 0.1265 | 1 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0175 | 0.0896 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0478 | 0.2826 | 0.609 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0175 | 0.0896 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0012 | 0.0014 |
Onchocerca volvulus | 0.0306 | 0.1731 | 1 | |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0055 | 0.0131 | 0.0722 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0294 | 0.1654 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.0229 | 0.0495 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0175 | 0.0896 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0044 | 0.0189 |
Brugia malayi | cytochrome P450 | 0.0055 | 0.0131 | 0.0283 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0102 | 0.022 |
Loa Loa (eye worm) | fli-1 protein | 0.0214 | 0.1144 | 0.247 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0175 | 0.0896 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0055 | 0.0131 | 0.0722 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0762 | 0.4632 | 0.5166 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0055 | 0.0131 | 0.0946 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0044 | 0.0189 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0055 | 0.0131 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 0.1731 | 0.3736 |
Loa Loa (eye worm) | hypothetical protein | 0.0762 | 0.4632 | 1 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0146 | 0.0709 | 0.1531 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0762 | 0.4632 | 1 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0762 | 0.4632 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0012 | 0.0027 |
Brugia malayi | Cytochrome P450 family protein | 0.0055 | 0.0131 | 0.0283 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0175 | 0.0896 | 0.706 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0055 | 0.0131 | 0.134 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0155 | 0.0767 | 0.6026 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0175 | 0.0896 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0762 | 0.4632 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0175 | 0.0896 | 0.706 |
Brugia malayi | Fli-1 protein | 0.0214 | 0.1144 | 0.247 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0055 | 0.0131 | 0.0946 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0055 | 0.0131 | 0.0722 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0175 | 0.0896 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0175 | 0.0896 | 0.706 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0762 | 0.4632 | 0.5166 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0055 | 0.0131 | 0.134 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0146 | 0.0709 | 0.1531 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.