TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 377.436 | Formula: C22H23N3O3
H donors: 2 H acceptors: 4 LogP: 3.94 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)[C@@H]1CC[C@H](CC1)CNc1nc(cc(n1)c1ccco1)c1ccccc1
InChi: 1S/C22H23N3O3/c26-21(27)17-10-8-15(9-11-17)14-23-22-24-18(16-5-2-1-3-6-16)13-19(25-22)20-7-4-12-28-20/h1-7,12-13,15,17H,8-11,14H2,(H,26,27)(H,23,24,25)/t15-,17-
InChiKey: OCKOIJVAHMEKGM-JCNLHEQBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	valosin containing protein	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	cell division control protein 48 aaa family protein	Get druggable targets OG5_126926	All targets in OG5_126926
Schistosoma mansoni	cell division control protein 48 aaa family protein	Get druggable targets OG5_126926	All targets in OG5_126926
Entamoeba histolytica	cdc48-like protein, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium falciparum	cell division cycle protein 48 homologue, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Leishmania braziliensis	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Schistosoma japonicum	Transitional endoplasmic reticulum ATPase homolog 2, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Leishmania major	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Cryptosporidium parvum	CDC48 like AAA ATPase ortholog	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium berghei	cell division cycle protein 48 homologue, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Leishmania mexicana	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Trypanosoma brucei gambiense	valosin-containing protein homolog,Transitional endoplasmic reticulum ATPase, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium vivax	cell division cycle ATPase, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium yoelii	cell division cycle protein 48 homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Mycobacterium tuberculosis	Putative conserved ATPase	Get druggable targets OG5_126926	All targets in OG5_126926
Toxoplasma gondii	cell division protein CDC48CY	Get druggable targets OG5_126926	All targets in OG5_126926
Onchocerca volvulus	Transitional endoplasmic reticulum ATPase homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Schistosoma mansoni	cell division control protein 48 aaa family protein	Get druggable targets OG5_126926	All targets in OG5_126926
Toxoplasma gondii	cell division protein CDC48AP	Get druggable targets OG5_126926	All targets in OG5_126926
Brugia malayi	transitional endoplasmic reticulum ATPase TER94, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Neospora caninum	hypothetical protein	Get druggable targets OG5_126926	All targets in OG5_126926
Trypanosoma congolense	Valosin-containing protein, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium knowlesi	cell division cycle protein 48 homologue, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Trypanosoma brucei	Valosin-containing protein	Get druggable targets OG5_126926	All targets in OG5_126926
Mycobacterium ulcerans	ATPase	Get druggable targets OG5_126926	All targets in OG5_126926
Toxoplasma gondii	transitional endoplasmic reticulum ATPase, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Babesia bovis	cell division cycle protein ATPase, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Schistosoma japonicum	ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative	Get druggable targets OG5_126926	All targets in OG5_126926
Entamoeba histolytica	transitional endoplasmic reticulum ATPase, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Neospora caninum	hypothetical protein	Get druggable targets OG5_126926	All targets in OG5_126926
Theileria parva	cell division cycle protein 48, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Loa Loa (eye worm)	VCP protein	Get druggable targets OG5_126926	All targets in OG5_126926
Trypanosoma cruzi	Valosin-containing protein, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Candida albicans	microsomal protein of CDC48 family of ATPases	Get druggable targets OG5_126926	All targets in OG5_126926
Theileria parva	cell division cycle protein 48, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Leishmania infantum	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium vivax	cell division cycle protein 48 homologue, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Trichomonas vaginalis	spermatogenesis associated factor, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Leishmania donovani	Valosin-containing protein, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	Get druggable targets OG5_126926	All targets in OG5_126926
Giardia lamblia	AAA family ATPase	Get druggable targets OG5_126926	All targets in OG5_126926
Babesia bovis	cell division control protein 48, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Echinococcus granulosus	transitional endoplasmic reticulum atpase	Get druggable targets OG5_126926	All targets in OG5_126926
Cryptosporidium hominis	cell division cycle protein 48	Get druggable targets OG5_126926	All targets in OG5_126926
Candida albicans	microsomal protein of CDC48 family of ATPases	Get druggable targets OG5_126926	All targets in OG5_126926

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0016	0.004	0.0063
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0124	0.0124
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0105	0.0659	0.1289
Schistosoma mansoni	bromodomain containing protein	0.0063	0.0364	0.0356
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0089	0.016
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0124	0.0107
Brugia malayi	intermediate filament protein	0.0028	0.0124	0.0124
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0128	0.0111
Brugia malayi	PHD-finger family protein	0.0026	0.0105	0.0105
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.0326	0.097
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0115	0.073	1
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	0.0014	0.0024	0.0031
Trichomonas vaginalis	penicillin-binding protein, putative	0.0115	0.073	1
Brugia malayi	beta-lactamase	0.0115	0.073	0.073
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0667	0.4592	0.4592
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0667	0.4592	0.908
Onchocerca volvulus		0.0115	0.073	0.0614
Schistosoma mansoni	hypothetical protein	0.0105	0.0659	0.0651
Echinococcus granulosus	ectonucleotide	0.0562	0.3858	0.7626
Onchocerca volvulus	GPI ethanolamine phosphate transferase 2 homolog	0.0105	0.0659	0.0542
Schistosoma mansoni	zinc finger protein	0.0021	0.0069	0.0061
Loa Loa (eye worm)	beta-lactamase	0.0115	0.073	0.0714
Trypanosoma brucei	Valosin-containing protein	0.0032	0.0152	0.0456
Echinococcus granulosus	lamin	0.0028	0.0124	0.0229
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0115	0.073	0.073
Mycobacterium tuberculosis	Probable hydrolase	0.0115	0.073	0.1324
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0031	0.0014
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0115	0.073	0.1324
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0667	0.4592	0.4588
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0659	0.0643
Mycobacterium tuberculosis	Probable esterase LipL	0.0115	0.073	0.1324
Schistosoma mansoni	cpg binding protein	0.0033	0.0153	0.0145
Trypanosoma brucei	endonuclease G, putative	0.0401	0.2729	1
Mycobacterium tuberculosis	Conserved protein	0.0115	0.073	0.1324
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0041	0.0065
Echinococcus multilocularis	lamin	0.0028	0.0124	0.0229
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0667	0.4592	0.908
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0105	0.0659	0.0659
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0128	0.0128
Schistosoma mansoni	hypothetical protein	0.0105	0.0659	0.0651
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0667	0.4592	0.4588
Schistosoma mansoni	cellular tumor antigen P53	0.0107	0.0676	0.0668
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0016	0.004	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0039	0.02	0.0183
Leishmania major	ethanolamine phosphotransferase, putative	0.0105	0.0659	0.2336
Onchocerca volvulus	GPI ethanolamine phosphate transferase 3 homolog	0.0105	0.0659	0.0542
Schistosoma mansoni	lamin	0.0028	0.0124	0.0116
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0111	0.0161
Leishmania major	hypothetical protein, conserved	0.0115	0.073	0.2598
Brugia malayi	MH2 domain containing protein	0.0132	0.0847	0.0847
Brugia malayi	valosin containing protein	0.002	0.0065	0.0065
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0667	0.4592	0.908
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.034	0.0657
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	0.0034	0.0164	0.0308
Plasmodium vivax	hypothetical protein, conserved	0.0115	0.073	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0292	0.0276
Onchocerca volvulus	GPI ethanolamine phosphate transferase 1 homolog	0.0105	0.0659	0.0542
Echinococcus granulosus	dnaJ subfamily B	0.0414	0.282	0.5569
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0659	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0403	0.0386
Brugia malayi	AEL166Cp	0.0105	0.0659	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0115	0.073	0.0714
Echinococcus granulosus	lamin dm0	0.0028	0.0124	0.0229
Brugia malayi	endonuclease G, mitochondrial precursor	0.0401	0.2729	0.2729
Onchocerca volvulus		0.0115	0.073	0.0614
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0676	0.066
Toxoplasma gondii	cell division protein CDC48CY	0.0034	0.0164	0.036
Mycobacterium tuberculosis	Probable lipase LipE	0.0115	0.073	0.1324
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0292	0.0292
Schistosoma mansoni	hypothetical protein	0.0017	0.0041	0.0033
Trypanosoma cruzi	endonuclease G, putative	0.0401	0.2729	1
Onchocerca volvulus		0.0029	0.0128	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0041	0.0024
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0356	0.0348
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0667	0.4592	0.908
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0111	0.0305
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0115	0.073	0.1324
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0045	0.0027
Echinococcus multilocularis	zinc finger protein	0.0021	0.0069	0.012
Brugia malayi	beta-lactamase family protein	0.0115	0.073	0.073
Echinococcus granulosus	microtubule associated protein 2	0.0727	0.501	0.9908
Mycobacterium ulcerans	hypothetical protein	0.0115	0.073	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0132	0.0847	0.0831
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0111	0.1382
Leishmania major	DNA/RNA non-specific endonuclease-like protein	0.0401	0.2729	1
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0041	0.0041
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0089	0.016
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0016	0.004	0.0063
Echinococcus multilocularis	ectonucleotide	0.0562	0.3858	0.7626
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0292	0.0292
Trypanosoma brucei	hypothetical protein, conserved	0.0115	0.073	0.2598
Schistosoma mansoni	hypothetical protein	0.002	0.0064	0.0056
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0041	0.0065
Echinococcus multilocularis	gpi ethanolamine phosphate transferase 3	0.0105	0.0659	0.1289
Brugia malayi	hypothetical protein	0.0105	0.0659	0.0659
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0021	0.0025
Plasmodium falciparum	cell division cycle protein 48 homologue, putative	0.0032	0.0152	0.0743
Mycobacterium ulcerans	esterase/lipase LipP	0.0115	0.073	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.034	0.0657
Loa Loa (eye worm)	MH2 domain-containing protein	0.0132	0.0847	0.0831
Echinococcus multilocularis	lamin dm0	0.0028	0.0124	0.0229
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0105	0.0659	0.1289
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0032	0.0152	0.0143
Brugia malayi	hypothetical protein	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0667	0.4592	0.4583
Echinococcus granulosus	gpi ethanolamine phosphate transferase 3	0.0105	0.0659	0.1289
Schistosoma mansoni	endonuclease related	0.0401	0.2729	0.2723
Schistosoma mansoni	hypothetical protein	0.0105	0.0659	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0667	0.4592	0.4583
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0168	0.0316
Trypanosoma cruzi	Valosin-containing protein, putative	0.0032	0.0152	0.0456
Echinococcus multilocularis	dnaJ subfamily B	0.0414	0.282	0.5569
Mycobacterium leprae	conserved hypothetical protein	0.0115	0.073	1
Loa Loa (eye worm)	VCP protein	0.0014	0.0024	0.0006
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0064	0.0047
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0021	0.0025
Trichomonas vaginalis	penicillin-binding protein, putative	0.0115	0.073	1
Echinococcus multilocularis	transferase	0.0105	0.0659	0.1289
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0124	0.0107
Onchocerca volvulus		0.0107	0.0676	0.0559
Mycobacterium ulcerans	beta-lactamase	0.0115	0.073	1
Echinococcus multilocularis	Alkaline phosphatase, core domain	0.0105	0.0659	0.1289
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0105	0.0659	0.0651
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0667	0.4592	0.4588
Leishmania major	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	0.0032	0.0152	0.0456
Echinococcus granulosus	transferase	0.0105	0.0659	0.1289
Mycobacterium tuberculosis	Probable lipase LipD	0.0115	0.073	0.1324
Plasmodium falciparum	GPI ethanolamine phosphate transferase 3, putative	0.0105	0.0659	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0041	0.0041
Schistosoma mansoni	hypothetical protein	0.0017	0.0041	0.0033
Toxoplasma gondii	ABC1 family protein	0.0115	0.073	0.2488
Trichomonas vaginalis	D-aminoacylase, putative	0.0115	0.073	1
Echinococcus granulosus	intermediate filament protein	0.0028	0.0124	0.0229
Schistosoma mansoni	lamin	0.0028	0.0124	0.0116
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0401	0.2729	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0111	0.0305
Brugia malayi	hypothetical protein	0.0017	0.0045	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0021	0.0004
Onchocerca volvulus	Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog	0.0105	0.0659	0.0542
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0045	0.0036
Echinococcus granulosus	beta LACTamase domain containing family member	0.0115	0.073	0.1429
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0044	0.0027
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0115	0.073	0.0722
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0041	0.0024
Entamoeba histolytica	phosphatidylinositol-glycan biosynthesis class O protein, putative	0.0105	0.0659	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0562	0.3858	0.3848
Onchocerca volvulus		0.0115	0.073	0.0614
Entamoeba histolytica	phosphatidylinositol-glycan biosynthesis class O protein, putative	0.0105	0.0659	1
Brugia malayi	Bromodomain containing protein	0.0037	0.0184	0.0184
Schistosoma mansoni	zinc finger protein	0.0015	0.0028	0.002
Onchocerca volvulus	Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog	0.0105	0.0659	0.0542
Schistosoma mansoni	cpg binding protein	0.0029	0.0128	0.012
Loa Loa (eye worm)	type I phosphodiesterase/nucleotide pyrophosphatase	0.0105	0.0659	0.0643
Schistosoma mansoni	hypothetical protein	0.0105	0.0659	0.0651
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0045	0.0036
Echinococcus granulosus	tumor protein p63	0.0734	0.5057	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.073	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0115	0.073	0.0714
Toxoplasma gondii	cell division protein CDC48AP	0.002	0.0068	0.00000035297
Trichomonas vaginalis	esterase, putative	0.0115	0.073	1
Giardia lamblia	Phosphatidylinositol-glycan biosynthesis, class O protein	0.0105	0.0659	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0115	0.073	1
Leishmania major	endonuclease G, putative	0.0401	0.2729	1
Onchocerca volvulus		0.0667	0.4592	0.4524
Mycobacterium ulcerans	lipase LipD	0.0115	0.073	1
Schistosoma mansoni	cpg binding protein	0.0033	0.0153	0.0145
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0401	0.2729	1
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0667	0.4592	0.908
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0041	0.0065
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0292	0.0276
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0045	0.0072
Trichomonas vaginalis	D-aminoacylase, putative	0.0115	0.073	1
Toxoplasma gondii	DNA/RNA non-specific endonuclease	0.0401	0.2729	1
Echinococcus granulosus	GPCR family 2	0.0017	0.0041	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0115	0.073	0.0714
Brugia malayi	vesicle-fusing ATPase	0.002	0.0065	0.0065
Onchocerca volvulus		0.0667	0.4592	0.4524
Echinococcus multilocularis	Endonuclease G	0.0401	0.2729	0.5389
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0667	0.4592	0.908
Brugia malayi	Bromodomain containing protein	0.0074	0.0443	0.0443
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0115	0.073	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0184	0.0167
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.144	1	1
Trypanosoma brucei	endonuclease G, putative	0.0401	0.2729	1
Brugia malayi	beta-lactamase family protein	0.0115	0.073	0.073
Echinococcus multilocularis	gpi ethanolamine phosphate transferase 1	0.0105	0.0659	0.1289
Schistosoma mansoni	hypothetical protein	0.0036	0.0176	0.0168
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0115	0.073	0.1429
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0667	0.4592	0.908
Echinococcus granulosus	transitional endoplasmic reticulum atpase	0.0034	0.0164	0.0308
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0016	0.004	0.0032
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0667	0.4592	0.908
Brugia malayi	hypothetical protein	0.0105	0.0659	0.0659
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0111	0.0305
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0667	0.4592	0.908
Schistosoma mansoni	hypothetical protein	0.0017	0.0041	0.0033
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0667	0.4592	0.4588
Schistosoma mansoni	hypothetical protein	0.0015	0.0028	0.002
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0115	0.073	0.1324
Leishmania major	hypothetical protein, conserved	0.0027	0.0111	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0028	0.012	0.0103
Schistosoma mansoni	hypothetical protein	0.0017	0.0041	0.0033
Loa Loa (eye worm)	vesicle-fusing ATPase	0.002	0.0065	0.0048
Trypanosoma brucei	endonuclease G, putative	0.0401	0.2729	1
Onchocerca volvulus	Transitional endoplasmic reticulum ATPase homolog	0.0034	0.0164	0.0041
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0168	0.0316
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0124	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0667	0.4592	0.4583
Plasmodium vivax	cell division cycle protein 48 homologue, putative	0.0032	0.0152	0.1949
Trypanosoma brucei	GPI ethanolamine phosphate transferase 3, putative	0.0105	0.0659	0.2336
Mycobacterium ulcerans	hypothetical protein	0.0105	0.0659	0.8931
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0124	0.0107
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.0045	0.0072
Loa Loa (eye worm)	hypothetical protein	0.002	0.0065	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0094
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0089	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0225	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0659	0.0643
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0014	0.0024	0.0015
Schistosoma mansoni	microtubule-associated protein tau	0.0727	0.501	0.5006
Onchocerca volvulus		0.144	1	1
Echinococcus granulosus	cpg binding protein	0.0033	0.0153	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0115	0.073	0.0714
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0735	0.5067	1
Echinococcus granulosus	zinc finger protein	0.0021	0.0069	0.012
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0667	0.4592	0.908
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0034	0.0164	0.0156
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0041	0.0065
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0105	0.0659	0.1289
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0659	0.0643
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0031	0.0031
Mycobacterium leprae	Probable lipase LipE	0.0115	0.073	1
Echinococcus multilocularis	microtubule associated protein 2	0.0727	0.501	0.9908
Brugia malayi	transitional endoplasmic reticulum ATPase TER94, putative	0.0014	0.0024	0.0024
Echinococcus multilocularis	musashi	0.0028	0.0124	0.0229
Trypanosoma cruzi	hypothetical protein, conserved	0.0115	0.073	0.2598
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0041	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0115	0.073	0.0714
Trypanosoma cruzi	endonuclease G, putative	0.0401	0.2729	1
Echinococcus multilocularis	tumor protein p63	0.0734	0.5057	1
Schistosoma mansoni	hypothetical protein	0.0414	0.282	0.2814
Trypanosoma cruzi	hypothetical protein, conserved	0.0115	0.073	0.2598
Schistosoma mansoni	hypothetical protein	0.144	1	1
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0667	0.4592	0.908
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0562	0.3858	0.7626
Mycobacterium tuberculosis	Conserved protein	0.0115	0.073	0.1324
Echinococcus granulosus	Endonuclease G	0.0401	0.2729	0.5389
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0115	0.073	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0176	0.0159
Echinococcus multilocularis	cpg binding protein	0.0033	0.0153	0.0286
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0562	0.3858	0.7626
Mycobacterium tuberculosis	Conserved protein	0.0115	0.073	0.1324

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.57 uM	Inhibition of human full length VCP (2 to 806 residues) expressed in High5 insect cells assessed as reduction in ATPase activity by measuring ADP formation by NADH coupled assay	ChEMBL.	25474526

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3361180

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 952257