Detailed information for compound 954516

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 217.287 | Formula: C12H11NOS
  • H donors: 0 H acceptors: 1 LogP: 2.89 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Sc1cccnc1
  • InChi: 1S/C12H11NOS/c1-14-10-4-6-11(7-5-10)15-12-3-2-8-13-9-12/h2-9H,1H3
  • InChiKey: DSDDBRBPKVSACO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide receptor 0.0036 0.0702 0.0602
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.013 0.023
Brugia malayi glutathione reductase 0.0037 0.0715 0.0715
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.013 0.0127
Schistosoma mansoni tubulin subunit alpha 0.0094 0.2171 0.2087
Echinococcus multilocularis tubulin beta 1 chain 0.0218 0.5282 0.5281
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.013 0.0111
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.013 0.013
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.0702 0.0699
Schistosoma mansoni neuropeptide receptor 0.0036 0.0702 0.0602
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0961 0.0843
Trypanosoma cruzi zeta tubulin, putative 0.0094 0.2171 0.2087
Brugia malayi Tachykinin-like peptides receptor 99D 0.0036 0.0702 0.0702
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0491 0.0488
Brugia malayi follicle stimulating hormone receptor 0.0036 0.0702 0.0702
Trichomonas vaginalis tubulin epsilon chain, putative 0.0218 0.5282 0.5231
Trypanosoma brucei beta tubulin 0.0218 0.5282 0.5231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0702 0.0602
Brugia malayi hypothetical protein 0.0036 0.0702 0.0702
Loa Loa (eye worm) tubulin beta-1 chain 0.0218 0.5282 0.5281
Mycobacterium ulcerans hypothetical protein 0.0047 0.0961 0.414
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0036 0.0702 0.0602
Toxoplasma gondii alpha tubulin TUBA1 0.0404 1 1
Brugia malayi RE15519p 0.0036 0.0702 0.0702
Brugia malayi MH2 domain containing protein 0.0016 0.0188 0.0188
Trypanosoma brucei trypanothione reductase 0.0037 0.0715 0.0615
Echinococcus multilocularis somatostatin receptor 0.0036 0.0702 0.0699
Onchocerca volvulus 0.0036 0.0702 0.2069
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.0702 0.0699
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1284 0.119
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0702 0.0699
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.0702 0.0602
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Echinococcus multilocularis muscleblind protein 1 0.0292 0.7172 0.7171
Schistosoma mansoni cpg binding protein 0.003 0.0531 0.0429
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0702 0.0699
Trichomonas vaginalis dynamin, putative 0.0091 0.2095 0.2009
Brugia malayi hypothetical protein 0.0036 0.0702 0.0702
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0715 0.0713
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Brugia malayi hypothetical protein 0.0036 0.0702 0.0702
Brugia malayi Dopamine receptor protein 1 0.0036 0.0702 0.0702
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0961 0.414
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0094 0.2171 0.2087
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.0702 0.0699
Schistosoma mansoni opsin-like receptor 0.0036 0.0702 0.0602
Loa Loa (eye worm) hypothetical protein 0.0014 0.013 0.0127
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0036 0.0702 0.0702
Loa Loa (eye worm) hypothetical protein 0.0047 0.0961 0.0959
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0036 0.0702 0.0702
Brugia malayi GnHR receptor homolog 0.0036 0.0702 0.0702
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0715 0.0615
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0036 0.0702 0.0702
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.013 0.0023
Brugia malayi ORL1-like opioid receptor 0.0036 0.0702 0.0702
Entamoeba histolytica dynamin-like protein 0.0091 0.2095 0.1991
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.0702 0.0699
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0702 0.0699
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.013 0.013
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.013 0.0111
Echinococcus granulosus Tubulin beta 2C chain 0.0218 0.5282 0.5281
Echinococcus granulosus Tubulin beta 2C chain 0.0218 0.5282 0.5281
Brugia malayi MH1 domain containing protein 0.0016 0.0188 0.0188
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Trypanosoma brucei epsilon tubulin 0.0218 0.5282 0.5231
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0961 0.0864
Trypanosoma brucei dynamin-1-like protein 0.0091 0.2095 0.2009
Brugia malayi Muscleblind-like protein 0.0292 0.7172 0.7172
Brugia malayi Tubulin alpha chain 0.0404 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0702 0.0699
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0036 0.0702 0.0602
Schistosoma mansoni amine GPCR 0.0036 0.0702 0.0602
Toxoplasma gondii beta tubulin 0.0218 0.5282 0.5231
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Brugia malayi MH1 domain containing protein 0.0016 0.0188 0.0188
Trichomonas vaginalis tubulin beta chain, putative 0.0404 1 1
Loa Loa (eye worm) hypothetical protein 0.0292 0.7172 0.7171
Loa Loa (eye worm) alpha-tubulin 0.0404 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.1909 0.8742
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0036 0.0702 0.0702
Brugia malayi MH1 domain containing protein 0.0009 0.0007 0.0007
Onchocerca volvulus 0.0036 0.0702 0.2069
Onchocerca volvulus 0.0036 0.0702 0.2069
Loa Loa (eye worm) hypothetical protein 0.0404 1 1
Schistosoma mansoni hypothetical protein 0.0036 0.0702 0.0602
Loa Loa (eye worm) hypothetical protein 0.0035 0.0664 0.0661
Brugia malayi Dynamin 0.0098 0.2273 0.2273
Loa Loa (eye worm) hypothetical protein 0.0035 0.0664 0.0661
Echinococcus granulosus tubulin gamma 1 chain 0.0218 0.5282 0.5281
Plasmodium vivax tubulin beta chain, putative 0.0218 0.5282 0.5231
Toxoplasma gondii dynamin-related protein DRPB 0.0091 0.2095 0.2009
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0728 0.0725
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0616 0.2556
Echinococcus multilocularis neuropeptide receptor A26 0.0036 0.0702 0.0699
Brugia malayi MH2 domain containing protein 0.0016 0.0188 0.0188
Brugia malayi G protein-coupled receptor F59B2.13 0.0036 0.0702 0.0702
Brugia malayi AMP-binding enzyme family protein 0.0014 0.013 0.013
Echinococcus multilocularis tubulin alpha 3 chain 0.0404 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0702 0.0602
Brugia malayi G-protein coupled receptor 0.0036 0.0702 0.0702
Brugia malayi Dopamine receptor 0.0036 0.0702 0.0702
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0702 0.0699
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0929 0.0927
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Schistosoma mansoni tubulin subunit epsilon 0.0218 0.5282 0.5231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0702 0.0602
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.013 0.0111
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0702 0.0699
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0123 0.2895 0.2818
Echinococcus granulosus tubulin alpha 1C chain 0.0404 1 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0961 0.0843
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0715 0.0615
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0664 1
Brugia malayi hypothetical protein 0.0036 0.0702 0.0702
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.0021 0.0021
Entamoeba histolytica tubulin alpha-1 chain 0.0404 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0218 0.5282 0.5231
Loa Loa (eye worm) alpha-tubulin isotype 2 0.031 0.7613 0.7612
Leishmania major alpha tubulin 0.0404 1 1
Echinococcus multilocularis allatostatin A receptor 0.0036 0.0702 0.0699
Trichomonas vaginalis dynamin, putative 0.0091 0.2095 0.2009
Schistosoma mansoni tubulin subunit beta 0.0218 0.5282 0.5231
Schistosoma mansoni tubulin subunit beta 0.0094 0.2171 0.2087
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.0702 0.0699
Trypanosoma brucei epsilon tubulin 0.0218 0.5282 0.5231
Schistosoma mansoni dynamin 0.0098 0.2273 0.2189
Echinococcus granulosus beta tubulin 0.0218 0.5282 0.5281
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.013 0.0023
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0036 0.0702 0.0699
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0961 0.0961
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.013 0.0127
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Onchocerca volvulus 0.0036 0.0702 0.2069
Plasmodium falciparum tubulin delta chain, putative 0.0094 0.2171 0.2087
Trichomonas vaginalis tubulin alpha chain, putative 0.0218 0.5282 0.5231
Brugia malayi hypothetical protein 0.0036 0.0702 0.0702
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0702 0.0699
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0036 0.0702 0.0699
Trypanosoma brucei beta tubulin 0.0218 0.5282 0.5231
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0036 0.0702 0.0602
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Schistosoma mansoni myosin xvIII 0.0036 0.0702 0.0602
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Echinococcus multilocularis tubulin alpha 0.0218 0.5282 0.5281
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0961 0.414
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Brugia malayi Cell division protein ftsZ 0.0094 0.2171 0.2171
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0036 0.0702 0.0699
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0036 0.0702 0.0699
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.013 0.0111
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.013 0.023
Trypanosoma cruzi epsilon tubulin, putative 0.0218 0.5282 0.5231
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.2146 0.9877
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0961 0.421
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.013 0.0023
Leishmania major delta tubulin, putative 0.0094 0.2171 0.2087
Echinococcus multilocularis dro:myosuppressin receptor 0.0036 0.0702 0.0699
Brugia malayi Tubulin alpha chain 0.0094 0.2171 0.2171
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.0702 0.0699
Plasmodium falciparum dynamin-like protein 0.0091 0.2095 0.2009
Schistosoma mansoni Smad4 0.0016 0.0188 0.0082
Trichomonas vaginalis dynamin, putative 0.0091 0.2095 0.2009
Loa Loa (eye worm) alpha-tubulin 0.0404 1 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.013 0.0023
Schistosoma mansoni neuropeptide receptor 0.0036 0.0702 0.0602
Giardia lamblia Gamma tubulin 0.0218 0.5282 0.5231
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.013 0.0111
Entamoeba histolytica dynamin-1-like protein, putative 0.0028 0.0483 0.0357
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0929 0.0929
Schistosoma mansoni amine GPCR 0.0036 0.0702 0.0602
Echinococcus multilocularis cpg binding protein 0.003 0.0531 0.0529
Leishmania major gamma-tubulin 0.0218 0.5282 0.5231
Onchocerca volvulus 0.0036 0.0702 0.2069
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0961 0.0961
Echinococcus multilocularis neuropeptide receptor 0.0036 0.0702 0.0699
Toxoplasma gondii thioredoxin reductase 0.0037 0.0715 0.0615
Echinococcus granulosus hypothetical protein 0.0036 0.0702 0.0699
Schistosoma mansoni amine GPCR 0.0036 0.0702 0.0602
Brugia malayi AMP-binding enzyme family protein 0.0014 0.013 0.013
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0107 0.012
Brugia malayi hypothetical protein 0.0036 0.0702 0.0702
Echinococcus multilocularis neuropeptide s receptor 0.0036 0.0702 0.0699
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0404 1 1
Brugia malayi hypothetical protein 0.0036 0.0702 0.0702
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0702 0.0699
Echinococcus granulosus neuropeptide receptor 0.0036 0.0702 0.0699
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.013 0.0023
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0702 0.0699
Trichomonas vaginalis tubulin beta chain, putative 0.0123 0.2895 0.2818
Echinococcus granulosus beta tubulin 0.0218 0.5282 0.5281
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.013 0.0023
Echinococcus granulosus Tubulin beta 2C chain 0.0218 0.5282 0.5281
Trypanosoma cruzi tubulin delta chain 0.0094 0.2171 0.2087
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.013 0.023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Brugia malayi Serotonin receptor 0.0036 0.0702 0.0702
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0036 0.0702 0.0699
Brugia malayi beta-tubulin, identical 0.0218 0.5282 0.5282
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0702 0.0699
Trichomonas vaginalis tubulin beta chain, putative 0.0404 1 1
Toxoplasma gondii alpha-tubulin I, putative 0.0404 1 1
Echinococcus granulosus muscleblind protein 0.0292 0.7172 0.7171
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Brugia malayi sulfakinin receptor protein 0.0036 0.0702 0.0702
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.2146 0.9877
Trichomonas vaginalis tubulin, putative 0.0123 0.2895 0.2818
Echinococcus multilocularis dynamin 1 0.0098 0.2273 0.227
Brugia malayi AMP-binding enzyme family protein 0.0014 0.013 0.013
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.013 0.023
Giardia lamblia Alpha-tubulin 0.0404 1 1
Loa Loa (eye worm) tubulin gamma chain 0.0218 0.5282 0.5281
Mycobacterium tuberculosis Cell division protein FtsZ 0.0094 0.2171 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0107 0.0107
Loa Loa (eye worm) oxidoreductase 0.0014 0.013 0.0127
Loa Loa (eye worm) hypothetical protein 0.0035 0.0664 0.0661
Trypanosoma cruzi alpha tubulin, putative 0.0404 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0281 0.6889 0.6855
Schistosoma mansoni tubulin subunit alpha 0.0404 1 1
Echinococcus multilocularis tubulin alpha chain 0.0404 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.5713 0.5712
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Giardia lamblia Beta tubulin 0.0218 0.5282 0.5231
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0702 0.0602
Echinococcus multilocularis neuropeptide receptor 0.0036 0.0702 0.0699
Plasmodium falciparum glutathione reductase 0.0037 0.0715 0.0615
Echinococcus multilocularis peroxisome assembly protein 26 0.0404 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0702 0.0699
Plasmodium falciparum dynamin-like protein 0.0091 0.2095 0.2009
Trichomonas vaginalis tubulin alpha chain, putative 0.0123 0.2895 0.2818
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0702 0.0602
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.2146 0.9874
Plasmodium vivax glutathione reductase, putative 0.0037 0.0715 0.0615
Schistosoma mansoni histamine h1 receptor 0.0036 0.0702 0.0602
Echinococcus multilocularis dynamin 1 protein 0.0091 0.2095 0.2092
Echinococcus granulosus g protein coupled receptor 0.0036 0.0702 0.0699
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0929 0.0927
Brugia malayi Tubulin alpha-2 chain 0.0404 1 1
Trypanosoma brucei alpha tubulin, putative 0.0123 0.2895 0.2818
Echinococcus granulosus tubulin alpha 3 chain 0.0404 1 1
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.013 0.0023
Schistosoma mansoni smad1 5 8 and 0.0016 0.0188 0.0082
Brugia malayi Tubulin beta-1 chain 0.0218 0.5282 0.5282
Brugia malayi neuropeptide F receptor 0.0036 0.0702 0.0702
Echinococcus multilocularis Smad4 0.0016 0.0188 0.0185
Brugia malayi Serotonin receptor 0.0036 0.0702 0.0702
Echinococcus granulosus tubulin alpha 0.0218 0.5282 0.5281
Brugia malayi neuropeptide F receptor 0.0036 0.0702 0.0702
Brugia malayi AMP-binding enzyme family protein 0.0014 0.013 0.013
Giardia lamblia Delta tubulin 0.0094 0.2171 0.2087
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Echinococcus granulosus Smad4 0.0016 0.0188 0.0185
Echinococcus granulosus fmrfamide receptor 0.0036 0.0702 0.0699
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0107 0.0104
Echinococcus granulosus tubulin beta 4A class IVa 0.0218 0.5282 0.5281
Trypanosoma brucei zeta tubulin 0.0094 0.2171 0.2087
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0929 0.0927
Echinococcus granulosus 7TM GPCR rhodopsin 0.0036 0.0702 0.0699
Schistosoma mansoni dynamin 0.0091 0.2095 0.2009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0929 0.0832
Loa Loa (eye worm) tubulin alpha chain 0.0404 1 1
Brugia malayi putative neuropeptide receptor 0.0036 0.0702 0.0702
Brugia malayi Tubulin beta chain 0.0123 0.2895 0.2895
Echinococcus granulosus tubulin alpha 3 chain 0.0404 1 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.013 0.023
Onchocerca volvulus 0.0036 0.0702 0.2069
Plasmodium falciparum tubulin epsilon chain, putative 0.0218 0.5282 0.5231
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.013 0.0023
Schistosoma mansoni hypothetical protein 0.0036 0.0702 0.0602
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0188 0.0185
Echinococcus multilocularis tubulin delta chain 0.0094 0.2171 0.2169
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0036 0.0702 0.0699
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.0702 0.0602
Loa Loa (eye worm) tubulin beta chain 0.0094 0.2171 0.2169
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0728 0.0725
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.0702 0.0699
Trichomonas vaginalis dynamin, putative 0.0091 0.2095 0.2009
Trichomonas vaginalis tubulin epsilon chain, putative 0.0404 1 1
Echinococcus granulosus neuropeptide s receptor 0.0036 0.0702 0.0699
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Schistosoma mansoni opsin-like receptor 0.0036 0.0702 0.0602
Trichomonas vaginalis dynamin, putative 0.0091 0.2095 0.2009
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0094 0.2171 0.2087
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.0702 0.0699
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.013 0.0111
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.013 0.0023
Echinococcus granulosus Tubulin beta 2C chain 0.0218 0.5282 0.5281
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0036 0.0702 0.0699
Brugia malayi Dynamin central region family protein 0.0091 0.2095 0.2095
Onchocerca volvulus 0.0036 0.0702 0.2069
Echinococcus multilocularis geminin 0.0165 0.3956 0.3954
Schistosoma mansoni tubulin subunit beta 0.0218 0.5282 0.5231
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0091 0.2095 0.2009
Treponema pallidum cell division protein FtsZ 0.0094 0.2171 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Plasmodium vivax tubulin epsilon chain, putative 0.0218 0.5282 0.5231
Echinococcus multilocularis Tubulin beta 2C chain 0.0218 0.5282 0.5281
Schistosoma mansoni biogenic amine receptor 0.0036 0.0702 0.0602
Echinococcus granulosus Tubulin alpha 1 chain 0.0404 1 1
Trypanosoma brucei dynamin-1-like protein 0.0091 0.2095 0.2009
Echinococcus multilocularis serotonin receptor 0.0036 0.0702 0.0699
Trypanosoma brucei beta tubulin 0.0218 0.5282 0.5231
Echinococcus multilocularis Tubulin beta 2C chain 0.0218 0.5282 0.5281
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0094 0.2171 0.2087
Echinococcus granulosus tubulin alpha chain 0.0404 1 1
Echinococcus granulosus dynamin 1 protein 0.0091 0.2095 0.2092
Leishmania major trypanothione reductase 0.0037 0.0715 0.0615
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0961 0.414
Brugia malayi CXXC zinc finger family protein 0.0028 0.0491 0.0491
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.0702 0.0699
Echinococcus granulosus alpha tubulin 0.0404 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Brugia malayi putative neuropeptide receptor NPR1 0.0036 0.0702 0.0702
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0664 0.2786
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0036 0.0702 0.0699
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0961 0.4074
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0036 0.0702 0.0602
Brugia malayi alpha-tubulin 0.0404 1 1
Echinococcus granulosus cpg binding protein 0.003 0.0531 0.0529
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.0702 0.0699
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0702 0.0602
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.013 0.0111
Trichomonas vaginalis tubulin beta chain, putative 0.0404 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0036 0.0702 0.0699
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.013 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.2171 0.2087
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.013 0.0127
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0036 0.0702 0.0699
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0702 0.0602
Trypanosoma brucei zeta tubulin, putative 0.0094 0.2171 0.2087
Loa Loa (eye worm) melatonin receptor type 1A 0.0036 0.0702 0.0699
Leishmania major zeta tubulin, putative 0.0094 0.2171 0.2087
Echinococcus multilocularis hypothetical protein 0.0404 1 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.2273 0.227
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.013 0.023
Echinococcus multilocularis tubulin subunit beta 0.0218 0.5282 0.5281
Trichomonas vaginalis tubulin epsilon chain, putative 0.0218 0.5282 0.5231
Echinococcus multilocularis Tubulin beta 2C chain 0.0218 0.5282 0.5281
Onchocerca volvulus 0.0047 0.0961 0.3008
Echinococcus granulosus alpha 1A adrenergic receptor 0.0036 0.0702 0.0699
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0929 0.0927
Echinococcus granulosus tubulin delta chain 0.0094 0.2171 0.2169
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Brugia malayi AKH receptor 0.0036 0.0702 0.0702
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.1909 0.8713
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0961 0.0864
Brugia malayi hypothetical protein 0.0036 0.0702 0.0702
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.0021 0.0021
Brugia malayi Smad1 0.0016 0.0188 0.0188
Echinococcus multilocularis sex peptide receptor 0.0036 0.0702 0.0699
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0036 0.0702 0.0602
Leishmania major alpha tubulin 0.0404 1 1
Leishmania major alpha tubulin 0.0404 1 1
Brugia malayi Dynamin 0.0098 0.2273 0.2273
Toxoplasma gondii beta-1 tubulin, putative 0.0218 0.5282 0.5231
Echinococcus multilocularis tubulin alpha 3 chain 0.0404 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Schistosoma mansoni tubulin subunit beta 0.0218 0.5282 0.5231
Schistosoma mansoni smad1 5 8 and 0.0016 0.0188 0.0082
Echinococcus granulosus neuropeptide receptor A26 0.0036 0.0702 0.0699
Schistosoma mansoni cpg binding protein 0.0028 0.0491 0.0388
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0961 0.421
Plasmodium vivax tubulin gamma chain, putative 0.0218 0.5282 0.5231
Loa Loa (eye worm) DRP-1 protein 0.0091 0.2095 0.2092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0616 0.2556
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0036 0.0702 0.0699
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Trypanosoma cruzi dynamin-1-like protein 0.0091 0.2095 0.2009
Trypanosoma brucei alpha tubulin 0.0404 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0404 1 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.013 0.023
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0107 0.0104
Trypanosoma brucei alpha tubulin 0.0404 1 1
Loa Loa (eye worm) tubulin alpha 2 0.031 0.7613 0.7612
Onchocerca volvulus 0.0036 0.0702 0.2069
Loa Loa (eye worm) TYRA-2 protein 0.0036 0.0702 0.0699
Echinococcus multilocularis G protein coupled receptor 139 0.0036 0.0702 0.0699
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0664 0.0563
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.0702 0.0602
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Brugia malayi Thioredoxin reductase 0.0037 0.0715 0.0715
Brugia malayi Tubulin beta chain 0.0094 0.2171 0.2171
Echinococcus granulosus g protein coupled receptor 0.0036 0.0702 0.0699
Trichomonas vaginalis tubulin, putative 0.0123 0.2895 0.2818
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0616 0.2556
Trichomonas vaginalis tubulin alpha chain, putative 0.0218 0.5282 0.5231
Schistosoma mansoni alpha tubulin 0.0404 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0218 0.5282 0.5231
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.013 0.0127
Brugia malayi Melatonin receptor type 1A 0.0036 0.0702 0.0702
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.013 0.023
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Trypanosoma cruzi beta tubulin, putative 0.0218 0.5282 0.5231
Echinococcus granulosus tubulin epsilon chain 0.0218 0.5282 0.5281
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0036 0.0702 0.0699
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0188 0.0185
Trichomonas vaginalis tubulin, putative 0.0094 0.2171 0.2087
Brugia malayi tubulin alpha chain - mouse 0.0404 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.013 0.0111
Echinococcus granulosus tubulin beta 1 chain 0.0218 0.5282 0.5281
Trichomonas vaginalis tubulin beta chain, putative 0.0404 1 1
Loa Loa (eye worm) BEN-1 protein 0.0218 0.5282 0.5281
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0702 0.0699
Trichomonas vaginalis tubulin beta chain, putative 0.0404 1 1
Schistosoma mansoni hypothetical protein 0.0036 0.0702 0.0602
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.2146 0.9877
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.0702 0.0699
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0961 0.414
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Onchocerca volvulus 0.0036 0.0702 0.2069
Echinococcus multilocularis beta tubulin 0.0218 0.5282 0.5281
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.0702 0.0602
Onchocerca volvulus 0.0036 0.0702 0.2069
Trypanosoma brucei tubulin delta chain 0.0094 0.2171 0.2087
Schistosoma mansoni hypothetical protein 0.0398 0.9855 0.9853
Loa Loa (eye worm) hypothetical protein 0.0035 0.0664 0.0661
Loa Loa (eye worm) hypothetical protein 0.0047 0.0961 0.0959
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0961 0.414
Echinococcus granulosus sex peptide receptor 0.0036 0.0702 0.0699
Loa Loa (eye worm) Smad1 0.0016 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.031 0.7613 0.7612
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.013 0.0111
Echinococcus granulosus tubulin alpha chain 0.0404 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Trypanosoma brucei epsilon tubulin 0.0218 0.5282 0.5231
Echinococcus granulosus tubulin alpha 1C chain 0.0404 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0961 0.0843
Echinococcus multilocularis dynamin 0.0091 0.2095 0.2092
Echinococcus multilocularis smad 0.0016 0.0188 0.0185
Loa Loa (eye worm) tubulin alpha chain 0.0404 1 1
Schistosoma mansoni tubulin subunit beta 0.0218 0.5282 0.5231
Echinococcus multilocularis beta tubulin 0.0218 0.5282 0.5281
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0961 0.414
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.013 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.013 0.0111
Leishmania major alpha tubulin 0.0404 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.0702 0.0602
Schistosoma mansoni adenoreceptor 0.0036 0.0702 0.0602
Schistosoma mansoni tubulin subunit delta 0.0094 0.2171 0.2087
Giardia lamblia Beta tubulin 0.0218 0.5282 0.5231
Echinococcus multilocularis neuropeptide FF receptor 2 0.0036 0.0702 0.0699
Echinococcus granulosus Tubulin alpha 1 chain 0.0404 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0702 0.0699
Toxoplasma gondii propionate-CoA ligase 0.0014 0.013 0.0023
Trypanosoma cruzi tubulin gamma chain 0.0218 0.5282 0.5231
Brugia malayi Tubulin gamma chain 0.0218 0.5282 0.5282
Trichomonas vaginalis tubulin alpha chain, putative 0.0123 0.2895 0.2818
Leishmania major alpha tubulin 0.0404 1 1
Schistosoma mansoni amine GPCR 0.0036 0.0702 0.0602
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0005
Loa Loa (eye worm) tubulin beta-4 chain 0.0218 0.5282 0.5281
Echinococcus multilocularis g-protein coupled receptor 0.0036 0.0702 0.0699
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.9855 0.9855
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.013 0.0023
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Brugia malayi G-protein coupled receptor 0.0036 0.0702 0.0702
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Mycobacterium leprae cell division protein FtsZ 0.0094 0.2171 1
Loa Loa (eye worm) glutathione reductase 0.0037 0.0715 0.0713
Loa Loa (eye worm) BEN-1 protein 0.0218 0.5282 0.5281
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.013 0.0111
Onchocerca volvulus 0.0036 0.0702 0.2069
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.1909 0.8742
Onchocerca volvulus Neuropeptide F receptor homolog 0.0036 0.0702 0.2069
Brugia malayi Dopamine receptor protein 2 0.0036 0.0702 0.0702
Echinococcus granulosus Tubulin alpha 1 chain 0.0404 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Echinococcus multilocularis orexin receptor type 2 0.0036 0.0702 0.0699
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.013 0.0023
Echinococcus granulosus tubulin alpha chain 0.0404 1 1
Schistosoma mansoni alpha tubulin 0.0404 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0218 0.5282 0.5231
Leishmania major alpha tubulin 0.0404 1 1
Plasmodium falciparum thioredoxin reductase 0.0037 0.0715 0.0615
Echinococcus multilocularis Tubulin beta 2C chain 0.0218 0.5282 0.5281
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0036 0.0702 0.2069
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0702 0.0699
Onchocerca volvulus 0.0036 0.0702 0.2069
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0702 0.0602
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Leishmania major epsilon tubulin, putative 0.0218 0.5282 0.5231
Echinococcus granulosus neuropeptide receptor 0.0036 0.0702 0.0699
Schistosoma mansoni smad 0.0016 0.0188 0.0082
Trichomonas vaginalis tubulin gamma chain, putative 0.0218 0.5282 0.5231
Toxoplasma gondii dynamin-related protein DRPA 0.0091 0.2095 0.2009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0702 0.0602
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0664 0.2698
Schistosoma mansoni neuropeptide receptor 0.0036 0.0702 0.0602
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0218 0.5282 0.5281
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Plasmodium vivax dynamin-like protein, putative 0.0091 0.2095 0.2009
Trichomonas vaginalis tubulin beta chain, putative 0.0218 0.5282 0.5231
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0036 0.0702 0.0602
Mycobacterium tuberculosis Probable reductase 0.0084 0.1909 0.8742
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0961 0.0961
Loa Loa (eye worm) tubulin alpha-2 chain 0.0404 1 1
Giardia lamblia Beta tubulin 0.0218 0.5282 0.5231
Echinococcus granulosus smad 0.0016 0.0188 0.0185
Loa Loa (eye worm) tubulin beta-2A chain 0.0218 0.5282 0.5281
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.013 0.0023
Echinococcus multilocularis G-protein coupled receptor, putative 0.0036 0.0702 0.0699
Trypanosoma brucei alpha tubulin 0.0404 1 1
Echinococcus multilocularis serotonin receptor 0.0036 0.0702 0.0699
Schistosoma mansoni tubulin subunit beta 0.0218 0.5282 0.5231
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.1909 0.8742
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Brugia malayi MH2 domain containing protein 0.0235 0.5713 0.5713
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0702 0.0699
Echinococcus granulosus dro:myosuppressin receptor 0.0036 0.0702 0.0699
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0616 0.2556
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0929 0.0927
Leishmania major alpha tubulin 0.0404 1 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0188 0.0082
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0094 0.2171 1
Schistosoma mansoni amine GPCR 0.0036 0.0702 0.0602
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0961 0.0864
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.0702 0.0699
Echinococcus granulosus somatostatin receptor 0.0036 0.0702 0.0699
Trypanosoma brucei beta tubulin 0.0218 0.5282 0.5231
Plasmodium vivax dynamin protein, putative 0.0091 0.2095 0.2009
Echinococcus granulosus g protein coupled receptor 0.0036 0.0702 0.0699
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Trypanosoma cruzi epsilon tubulin, putative 0.0218 0.5282 0.5231
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.013 0.0111
Echinococcus granulosus tubulin alpha chain 0.0404 1 1
Toxoplasma gondii beta-tubulin, putative 0.0218 0.5282 0.5231
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0702 0.0699
Echinococcus multilocularis tubulin alpha chain 0.0404 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.013 0.0111
Brugia malayi larval opioid receptor 0.0036 0.0702 0.0702
Schistosoma mansoni tubulin subunit alpha 0.0404 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0036 0.0702 0.0699
Echinococcus granulosus tachykinin peptides receptor 99D 0.0036 0.0702 0.0699
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0929 0.0832
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.013 0.023
Echinococcus multilocularis tubulin gamma 1 chain 0.0218 0.5282 0.5281
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0702 0.0699
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.031 0.7613 0.7587
Loa Loa (eye worm) tubulin beta chain 0.0218 0.5282 0.5281
Echinococcus granulosus peroxisome assembly protein 26 0.0404 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.0702 0.0602
Echinococcus multilocularis Tubulin alpha 1 chain 0.0404 1 1
Brugia malayi hypothetical protein 0.0036 0.0702 0.0702
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.013 0.023
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.013 0.023
Trichomonas vaginalis dynamin, putative 0.0091 0.2095 0.2009
Echinococcus granulosus geminin 0.0165 0.3956 0.3954
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.013 0.0111
Plasmodium vivax tubulin alpha chain, putative 0.0404 1 1
Leishmania major GTP-binding protein, putative 0.0091 0.2095 0.2009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Schistosoma mansoni tubulin subunit beta 0.0218 0.5282 0.5231
Onchocerca volvulus 0.0036 0.0702 0.2069
Trichomonas vaginalis tubulin alpha chain, putative 0.0123 0.2895 0.2818
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Loa Loa (eye worm) hypothetical protein 0.0281 0.6889 0.6888
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.2171 0.2087
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0715 0.3033
Trichomonas vaginalis tubulin gamma chain, putative 0.0094 0.2171 0.2087
Echinococcus granulosus tubulin alpha chain 0.0404 1 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0188 0.0185
Schistosoma mansoni biogenic amine receptor 0.0036 0.0702 0.0602
Trypanosoma cruzi zeta tubulin, putative 0.0094 0.2171 0.2087
Echinococcus multilocularis fmrfamide receptor 0.0036 0.0702 0.0699
Toxoplasma gondii dynamin gtpase 0.006 0.1306 0.1213
Echinococcus multilocularis tubulin epsilon chain 0.0218 0.5282 0.5281
Giardia lamblia Alpha-tubulin 0.0404 1 1
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0961 0.414
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0036 0.0702 0.0699
Schistosoma mansoni tubulin subunit alpha 0.0404 1 1
Schistosoma mansoni hypothetical protein 0.0036 0.0702 0.0602
Schistosoma mansoni neuropeptide f receptor 76f 0.0036 0.0702 0.0602
Onchocerca volvulus 0.0036 0.0702 0.2069
Echinococcus multilocularis Tubulin alpha 1 chain 0.0404 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0702 0.0699
Loa Loa (eye worm) beta-tubulin 0.0218 0.5282 0.5281
Trichomonas vaginalis tubulin, putative 0.0218 0.5282 0.5231
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0036 0.0702 0.0699
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0036 0.0702 0.0699
Echinococcus granulosus dynamin 0.0091 0.2095 0.2092
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0702 0.0699
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0702 0.0699
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Echinococcus granulosus Tubulin beta 2C chain 0.0218 0.5282 0.5281
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0702 0.0699
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0702 0.0699
Trichomonas vaginalis mgm1, putative 0.0091 0.2095 0.2009
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0036 0.0702 0.0699
Echinococcus granulosus serotonin receptor 0.0036 0.0702 0.0699
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0664 0.0563
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Brugia malayi hypothetical protein 0.0036 0.0702 0.0702
Plasmodium falciparum alpha tubulin 2 0.0404 1 1
Brugia malayi G protein-coupled receptor 0.0036 0.0702 0.0702
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0036 0.0702 0.0699
Echinococcus granulosus dnaJ subfamily B 0.0398 0.9855 0.9855
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0702 0.0699
Trypanosoma brucei beta tubulin 0.0218 0.5282 0.5231
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.013 0.0111
Loa Loa (eye worm) tubulin alpha 2 0.0187 0.4502 0.45
Echinococcus granulosus g-protein coupled receptor 0.0036 0.0702 0.0699
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.5713 0.5712
Echinococcus multilocularis tubulin alpha 1C chain 0.0404 1 1
Onchocerca volvulus 0.0036 0.0702 0.2069
Brugia malayi Tubulin alpha-2 chain 0.0404 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0218 0.5282 0.5281
Schistosoma mansoni alpha tubulin 0.0404 1 1
Loa Loa (eye worm) hypothetical protein 0.0292 0.7172 0.7171
Plasmodium vivax delta tubulin, putative 0.0094 0.2171 0.2087
Echinococcus granulosus peptide allatostatin:somatostatin 0.0036 0.0702 0.0699
Onchocerca volvulus 0.0036 0.0702 0.2069
Leishmania major alpha tubulin 0.0404 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0702 0.0699
Trichomonas vaginalis tubulin beta chain, putative 0.0404 1 1
Entamoeba histolytica dynamin-1-like protein, putative 0.0091 0.2095 0.1991
Schistosoma mansoni hypothetical protein 0.0165 0.3956 0.3891
Plasmodium vivax tubulin alpha chain, putative 0.0404 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0036 0.0702 0.0699
Entamoeba histolytica tubulin family protein 0.0218 0.5282 0.522
Echinococcus multilocularis tubulin alpha chain 0.0404 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Echinococcus granulosus allatostatin A receptor 0.0036 0.0702 0.0699
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0702 0.0699
Echinococcus multilocularis Tubulin alpha 1 chain 0.0404 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.013 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.013 0.0111
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.0702 0.0699
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.013 0.0111
Entamoeba histolytica tubulin gamma chain 0.0218 0.5282 0.522
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.1909 0.8742
Loa Loa (eye worm) hypothetical protein 0.0014 0.013 0.0127
Mycobacterium ulcerans cell division protein FtsZ 0.0094 0.2171 1
Echinococcus granulosus dynamin 1 0.0098 0.2273 0.227
Echinococcus granulosus tubulin subunit TubB 0.0404 1 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0961 0.4074
Schistosoma mansoni cpg binding protein 0.003 0.0531 0.0429
Plasmodium falciparum alpha tubulin 1 0.0404 1 1
Schistosoma mansoni hypothetical protein 0.0165 0.3956 0.3891
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0188 0.0185
Loa Loa (eye worm) tubulin alpha 2 0.031 0.7613 0.7612
Leishmania major alpha tubulin 0.0404 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.0702 0.0699
Entamoeba histolytica tubulin alpha chain, putative 0.0404 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0702 0.0699
Echinococcus multilocularis fmrfamide receptor 0.0036 0.0702 0.0699
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0702 0.0699
Entamoeba histolytica tubulin family protein 0.0218 0.5282 0.522
Echinococcus multilocularis tubulin alpha 1C chain 0.0404 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0036 0.0702 0.0702
Loa Loa (eye worm) hypothetical protein 0.0047 0.0961 0.0959
Onchocerca volvulus 0.0123 0.2895 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0036 0.0702 0.0602
Schistosoma mansoni opsin-like receptor 0.0036 0.0702 0.0602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0929 0.0832
Echinococcus multilocularis muscleblind protein 0.0292 0.7172 0.7171
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0188 0.0185
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.013 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0702 0.0602
Onchocerca volvulus 0.0028 0.0491 0.1307
Schistosoma mansoni alpha-1 adrenergic receptor 0.0036 0.0702 0.0602
Trypanosoma brucei tubulin gamma chain 0.0218 0.5282 0.5231
Echinococcus multilocularis tubulin alpha chain 0.0404 1 1
Trypanosoma brucei alpha tubulin 0.0404 1 1
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Leishmania major alpha tubulin 0.0404 1 1
Plasmodium falciparum tubulin gamma chain 0.0218 0.5282 0.5231
Onchocerca volvulus 0.0036 0.0702 0.2069
Schistosoma mansoni dynamin 0.0098 0.2273 0.2189
Loa Loa (eye worm) nuclear factor I 0.0009 0.0007 0.0005
Schistosoma mansoni tubulin subunit gamma 0.0218 0.5282 0.5231
Schistosoma mansoni smad1 5 8 and 0.0016 0.0188 0.0082
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.1909 0.8742
Echinococcus granulosus 7tm_1 domain containing protein 0.0036 0.0702 0.0699
Leishmania major alpha tubulin 0.0404 1 1
Schistosoma mansoni biogenic amine receptor 0.0036 0.0702 0.0602
Trichomonas vaginalis tubulin epsilon chain, putative 0.0094 0.2171 0.2087
Loa Loa (eye worm) hypothetical protein 0.0036 0.0702 0.0699
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0036 0.0702 0.0602
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0036 0.0702 0.0602
Echinococcus multilocularis tubulin subunit TubB 0.0404 1 1
Giardia lamblia Dynamin 0.0091 0.2095 0.2009
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1124 0.1028
Loa Loa (eye worm) tubulin alpha-3 chain 0.0281 0.6889 0.6888
Echinococcus granulosus tubulin subunit beta 0.0218 0.5282 0.5281
Plasmodium falciparum tubulin beta chain 0.0218 0.5282 0.5231
Loa Loa (eye worm) hypothetical protein 0.0035 0.0664 0.0661
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0702 0.0699
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0702 0.0602
Brugia malayi MH1 domain containing protein 0.0009 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0702 0.0602
Echinococcus multilocularis tubulin alpha chain 0.0404 1 1
Leishmania major beta tubulin 0.0218 0.5282 0.5231
Trypanosoma cruzi tubulin delta chain 0.0094 0.2171 0.2087
Echinococcus granulosus G protein coupled receptor 139 0.0036 0.0702 0.0699
Leishmania major alpha tubulin 0.0404 1 1
Echinococcus granulosus orexin receptor type 2 0.0036 0.0702 0.0699
Giardia lamblia Epsilon tubulin 0.0094 0.2171 0.2087

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 17 % Inhibition of human recombinant PDE7A1 assessed as inhibition of hydrolysis of [3H]cAMP at 10 uM after 20 mins by scintillation proximity assay ChEMBL. 25264825

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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