Detailed information for compound 976802

Basic information

Technical information
  • TDR Targets ID: 976802
  • Name: (3E,5E)-1-methyl-3,5-bis[(4-nitrophenyl)methy lidene]piperidin-4-one
  • MW: 379.366 | Formula: C20H17N3O5
  • H donors: 0 H acceptors: 5 LogP: 3.29 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1C/C(=C\c2ccc(cc2)[N+](=O)[O-])/C(=O)/C(=C/c2ccc(cc2)[N+](=O)[O-])/C1
  • InChi: 1S/C20H17N3O5/c1-21-12-16(10-14-2-6-18(7-3-14)22(25)26)20(24)17(13-21)11-15-4-8-19(9-5-15)23(27)28/h2-11H,12-13H2,1H3/b16-10+,17-11+
  • InChiKey: RZSZIUWKHOTPLG-OTYYAQKOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3E,5E)-1-methyl-3,5-bis[(4-nitrophenyl)methylene]piperidin-4-one
  • (3E,5E)-1-methyl-3,5-bis[(4-nitrophenyl)methylene]-4-piperidinone
  • (3E,5E)-1-methyl-3,5-bis(4-nitrobenzylidene)-4-piperidone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0032 0.0073
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0138 0.0403
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0432 0.2688 0.8557
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0067 0.0308
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0032 0.0073
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0032 0.0022
Loa Loa (eye worm) sugar transporter 0.0103 0.0581 0.1851
Leishmania major C-8 sterol isomerase-like protein 0.0432 0.2688 1
Leishmania major cathepsin L-like protease 0.013 0.0754 0.2774
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0117 0.1262
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0124 0.042
Onchocerca volvulus 0.0034 0.0138 0.0403
Schistosoma mansoni protein kinase 0.0032 0.0122 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0138 0.044
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.015 0.051
Brugia malayi Cathepsin L-like precursor 0.0034 0.0138 0.0412
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0122 0.0404
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0032 0.0074
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Echinococcus granulosus microtubule associated protein 2 0.1392 0.8832 1
Plasmodium vivax vivapain-1 0.0018 0.0032 0.0073
Brugia malayi beta-lactamase 0.011 0.0624 0.1965
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0138 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0109 0.0109
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0067 0.0201
Schistosoma mansoni metabotropic glutamate receptor 0.0019 0.0043 0.0035
Schistosoma mansoni hypothetical protein 0.0103 0.0581 0.0645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Schistosoma mansoni hypothetical protein 0.0031 0.0115 0.0117
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Onchocerca volvulus 0.011 0.0624 0.1957
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Brugia malayi intermediate filament protein 0.0026 0.0087 0.025
Entamoeba histolytica hypothetical protein 0.0072 0.0377 1
Leishmania major basic transcription factor 3a, putative 0.0034 0.0137 0.0468
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0122 0.0138
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0124 0.042
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0138 0.0143
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0138 0.0143
Onchocerca volvulus 0.0026 0.0087 0.0241
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.015 0.0779
Brugia malayi MH2 domain containing protein 0.0017 0.0025 0.0051
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0067 0.0067
Echinococcus granulosus solute carrier family 22 0.0015 0.0012 0.0013
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0137 0.0468
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0703 0.4425 1
Loa Loa (eye worm) Smad1 0.0017 0.0025 0.0079
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0294 0.032
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0117 0.012
Echinococcus multilocularis GPCR, family 2 0.0031 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0032 0.0074
Trichomonas vaginalis esterase, putative 0.011 0.0624 1
Trypanosoma brucei glucose transporter 1E 0.0032 0.0124 0.042
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0122 0.0617
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Mycobacterium leprae conserved hypothetical protein 0.011 0.0624 1
Schistosoma mansoni transcription factor btf3 0.0034 0.0137 0.0142
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0124 0.042
Plasmodium vivax hypothetical protein, conserved 0.011 0.0624 0.2252
Leishmania major glucose transporter, lmgt1 0.0032 0.0124 0.042
Loa Loa (eye worm) hypothetical protein 0.0026 0.0084 0.0268
Plasmodium falciparum hexose transporter 0.0103 0.0581 0.2094
Loa Loa (eye worm) beta-lactamase 0.011 0.0624 0.1988
Echinococcus multilocularis cysteine protease 0.0034 0.0138 0.0138
Echinococcus granulosus smad 0.0017 0.0025 0.0028
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0624 0.1387
Echinococcus granulosus Smad4 0.0017 0.0025 0.0028
Trypanosoma brucei glucose transporter 2A 0.0032 0.0124 0.042
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0624 0.1387
Mycobacterium ulcerans lipase LipD 0.011 0.0624 1
Plasmodium vivax vivapain-2 0.0034 0.0138 0.0464
Brugia malayi hypothetical protein 0.0015 0.0012 0.0009
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0294 0.1589
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0581 0.0581
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0122 0.0404
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.0754 0.2774
Loa Loa (eye worm) hypothetical protein 0.0049 0.0232 0.0739
Brugia malayi cathepsin L-like precursor 0.0023 0.0066 0.0181
Mycobacterium tuberculosis Conserved protein 0.011 0.0624 0.1387
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.1476 0.47
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0624 0.1387
Brugia malayi MH2 domain containing protein 0.0017 0.0025 0.0051
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0122 0.0387
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0067 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0581 0.0658
Loa Loa (eye worm) glutamate receptor 0.004 0.0173 0.0551
Schistosoma mansoni Smad4 0.0017 0.0025 0.0015
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0138 0.0464
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0581 0.0581
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0624 0.1387
Leishmania major cathepsin L-like protease 0.0034 0.0138 0.0471
Loa Loa (eye worm) hypothetical protein 0.0031 0.0115 0.0366
Schistosoma mansoni protein kinase 0.0032 0.0122 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0624 1
Onchocerca volvulus 0.0034 0.0138 0.0403
Schistosoma mansoni glucose transport protein 0.0103 0.0581 0.0645
Entamoeba histolytica hypothetical protein 0.0072 0.0377 1
Schistosoma mansoni hypothetical protein 0.0031 0.0115 0.0117
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0067 0.0204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Trypanosoma cruzi major cysteine proteinase, putative 0.0103 0.0575 0.2106
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.015 0.0518
Onchocerca volvulus 0.0034 0.0138 0.0403
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0624 0.0694
Plasmodium vivax CDK-related protein kinase 6, putative 0.0439 0.273 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0012 0.0012
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0624 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Schistosoma mansoni hypothetical protein 0.0072 0.0377 0.0414
Plasmodium falciparum cysteine proteinase falcipain 1 0.0018 0.0032 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Schistosoma mansoni smad 0.0017 0.0025 0.0015
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0122 0.0404
Onchocerca volvulus 0.011 0.0624 0.1957
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.015 0.0518
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.011 0.0624 0.1988
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0374
Echinococcus multilocularis solute carrier family 22 0.0015 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.011 0.0624 0.1988
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0209
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0138 0.044
Entamoeba histolytica protein kinase, putative 0.0032 0.0122 0.2603
Loa Loa (eye worm) hypothetical protein 0.0432 0.2688 0.8561
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0538 0.1692
Echinococcus granulosus vesicular acetylcholine transporter 0.0503 0.314 0.3555
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0624 0.2287
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0209
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.015 0.0518
Echinococcus multilocularis solute carrier family 22 0.0015 0.0012 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0624 1
Echinococcus granulosus cathepsin l1 0.0034 0.0138 0.0156
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0012 0.0038
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0 0.0001
Echinococcus granulosus neuropeptide receptor A26 0.046 0.2868 0.3247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0377 0.0427
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0255
Echinococcus multilocularis Smad4 0.0017 0.0025 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0138 0.0156
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0067 0.0062
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0137 0.0437
Echinococcus granulosus General substrate transporter 0.0089 0.0488 0.0553
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0009 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Brugia malayi metabotropic glutamate receptor type 2 0.0019 0.0043 0.0108
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0117 0.2484
Mycobacterium leprae Probable lipase LipE 0.011 0.0624 1
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0066 0.0061
Loa Loa (eye worm) hypothetical protein 0.0231 0.1398 0.4453
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0624 0.1387
Plasmodium falciparum mitogen-activated protein kinase 2 0.0167 0.0989 0.3595
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0067 0.0075
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0581 0.0581
Leishmania major protein kinase, putative 0.0032 0.0122 0.041
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0087 0.025
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0117 0.0133
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0066 0.0181
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0049 0.0232 0.0232
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0122 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0124 0.1835
Loa Loa (eye worm) hypothetical protein 0.0026 0.0087 0.0278
Toxoplasma gondii protein kinase, putative 0.0292 0.179 1
Echinococcus granulosus geminin 0.0669 0.4206 0.4762
Brugia malayi beta-NAC-like protein 0.0034 0.0137 0.0409
Echinococcus granulosus GPCR family 2 0.0031 0.0115 0.013
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.015 0.0518
Onchocerca volvulus 0.0034 0.0138 0.0403
Echinococcus granulosus solute carrier family 22 0.0015 0.0012 0.0013
Schistosoma mansoni smad1 5 8 and 0.0017 0.0025 0.0015
Echinococcus multilocularis solute carrier family 22 0.0015 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0538 0.1715
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Loa Loa (eye worm) hypothetical protein 0.011 0.0624 0.1988
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0138 0.0138
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0115 0.013
Echinococcus granulosus metabotropic glutamate receptor 5 0.0049 0.0232 0.0263
Onchocerca volvulus 0.0047 0.022 0.0667
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0031 0.0072
Onchocerca volvulus 0.0034 0.0138 0.0403
Onchocerca volvulus 0.011 0.0624 0.1957
Echinococcus granulosus solute carrier family 22 0.0015 0.0012 0.0013
Brugia malayi Cathepsin L-like precursor 0.0023 0.0066 0.0181
Entamoeba histolytica hypothetical protein 0.0072 0.0377 1
Echinococcus multilocularis General substrate transporter 0.0089 0.0488 0.0488
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0025 0.0028
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0122 0.036
Schistosoma mansoni hypothetical protein 0.0047 0.022 0.0236
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0624 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0122 0.0387
Entamoeba histolytica protein kinase, putative 0.0032 0.0122 0.2603
Echinococcus multilocularis smad 0.0017 0.0025 0.0025
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0067 0.0204
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0122 0.0617
Schistosoma mansoni smad1 5 8 and 0.0017 0.0025 0.0015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Schistosoma mansoni metabotropic glutamate receptor 0.0033 0.0132 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Mycobacterium tuberculosis Conserved protein 0.011 0.0624 0.1387
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0122 0.0138
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0117 0.0117
Echinococcus multilocularis transcription factor btf3 0.0034 0.0137 0.0137
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0122 0.0387
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0377 0.0377
Echinococcus multilocularis neuropeptide s receptor 0.046 0.2868 0.2868
Echinococcus granulosus neuropeptide s receptor 0.046 0.2868 0.3247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Onchocerca volvulus 0.0034 0.0138 0.0403
Mycobacterium ulcerans beta-lactamase 0.011 0.0624 1
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0066 0.098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0032 0.0324
Echinococcus granulosus lamin 0.0026 0.0087 0.0099
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0087 0.0278
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0067 0.0894
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0032 0.0074
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0117 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0624 0.1988
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0124 0.042
Loa Loa (eye worm) hypothetical protein 0.0066 0.0342 0.1091
Trypanosoma cruzi cruzipain precursor, putative 0.013 0.0754 0.2774
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0067 0.0184
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0036 0.0149 0.0448
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.0754 0.2774
Brugia malayi Cathepsin L-like precursor 0.0034 0.0138 0.0412
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0138 0.0403
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0109 0.0123
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0047
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0294 0.1056
Plasmodium falciparum proline--tRNA ligase 0.0036 0.015 0.051
Plasmodium vivax vivapain-3 0.0018 0.0032 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0212
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0624 0.1387
Brugia malayi Cathepsin L-like precursor 0.0023 0.0066 0.0181
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.1398 0.1583
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.015 0.0518
Brugia malayi Cam kinase protein 1 0.0032 0.0122 0.036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Brugia malayi hypothetical protein 0.0072 0.0377 0.1175
Schistosoma mansoni smad1 5 8 and 0.0017 0.0025 0.0015
Brugia malayi Cathepsin L-like precursor 0.0034 0.0138 0.0412
Leishmania major cathepsin L-like protease 0.013 0.0754 0.2774
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0124 0.1835
Schistosoma mansoni glucose transport protein 0.0103 0.0581 0.0645
Leishmania major cathepsin L-like protease 0.013 0.0754 0.2774
Brugia malayi Sugar transporter family protein 0.0103 0.0581 0.1828
Brugia malayi major facilitator superfamily protein 0.0015 0.0012 0.0009
Brugia malayi Smad1 0.0017 0.0025 0.0051
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0122 0.0122
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0503 0.314 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus granulosus cysteine protease 0.0018 0.0032 0.0036
Echinococcus multilocularis microtubule associated protein 2 0.1392 0.8832 0.8832
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0624 1
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0032 0.0036
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0034 0.0138 0.044
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0138 0.2061
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0503 0.314 1
Schistosoma mansoni hypothetical protein 0.0669 0.4206 0.4755
Schistosoma mansoni hypothetical protein 0.0066 0.0342 0.0375
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0294 0.064
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0137 0.2045
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0124 0.1835
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0624 0.1988
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0294 0.032
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0138 0.0403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0624 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0624 0.1387
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.022 0.0676
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0624 0.0706
Plasmodium falciparum protein kinase 6 0.0439 0.273 1
Leishmania major hypothetical protein, conserved 0.011 0.0624 0.2287
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0012 0.0038
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0012 0.5
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0012 0.0009
Echinococcus granulosus lamin dm0 0.0026 0.0087 0.0099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0032 0.0074
Echinococcus granulosus intermediate filament protein 0.0026 0.0087 0.0099
Toxoplasma gondii cathepsin CPL 0.0034 0.0138 0.0709
Plasmodium vivax vivapain-2 0.0034 0.0138 0.0464
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0581 0.0658
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0122 0.041
Brugia malayi hypothetical protein 0.0231 0.1398 0.4437
Mycobacterium tuberculosis Conserved protein 0.011 0.0624 0.1387
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0294 0.4616
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0137 0.0704
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0032 0.0022
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0025 0.0079
Leishmania major cathepsin L-like protease 0.0034 0.0138 0.0471
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0624 0.0694
Loa Loa (eye worm) hypothetical protein 0.011 0.0624 0.1988
Entamoeba histolytica hypothetical protein 0.0023 0.0067 0.1011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0067 0.0384
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0115 0.0366
Loa Loa (eye worm) hypothetical protein 0.0221 0.1334 0.4249
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0294 0.0333
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0122 0.0138
Loa Loa (eye worm) sugar transporter 0.0015 0.0012 0.0038
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0025 0.0025
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0044 0.0073
Echinococcus multilocularis cathepsin L 0.0018 0.0032 0.0032
Brugia malayi vesicular acetylcholine transporter unc-17 0.0503 0.314 1
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0122 0.1792
Schistosoma mansoni lamin 0.0026 0.0087 0.0085
Echinococcus multilocularis lamin 0.0026 0.0087 0.0087
Schistosoma mansoni survival motor neuron protein 0.0047 0.022 0.0236
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0137 0.2045
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0115 0.0338
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0581 0.0658
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0012 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0137 0.3052
Brugia malayi MH2 domain containing protein 0.0243 0.1476 0.4685
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0087 0.0278
Leishmania major glucose transporter, lmgt2 0.0032 0.0124 0.042
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0115 0.0115
Brugia malayi Cathepsin L-like precursor 0.0034 0.0138 0.0412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0294 0.0294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0032 0.0074
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0044 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0581 0.93
Loa Loa (eye worm) hypothetical protein 0.0023 0.0066 0.0209
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0624 0.2287
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0025 0.0028
Onchocerca volvulus 0.0023 0.0066 0.0172
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0122 0.0122
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0342 0.1065
Entamoeba histolytica cysteine protease, putative 0.0034 0.0138 0.308
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Loa Loa (eye worm) fibroinase 0.0034 0.0138 0.044
Schistosoma mansoni glucose transport protein 0.0103 0.0581 0.0645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0122 0.0404
Plasmodium vivax hexose transporter 0.0103 0.0581 0.2094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0066 0.0877
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0067 0.5182
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0032 0.0074
Brugia malayi hypothetical protein 0.0015 0.0012 0.0009
Brugia malayi Sugar transporter family protein 0.0015 0.0012 0.0009
Toxoplasma gondii ABC1 family protein 0.011 0.0624 0.3442
Echinococcus granulosus cathepsin L 0.0018 0.0032 0.0036
Loa Loa (eye worm) hypothetical protein 0.0097 0.0538 0.1715
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0124 0.042
Brugia malayi Metabotropic glutamate receptor precursor. 0.004 0.0173 0.0524
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.0581 0.0581
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0124 0.1835
Entamoeba histolytica hypothetical protein 0.0072 0.0377 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0138 0.0471
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0137 0.0468
Loa Loa (eye worm) glutamate receptor 0.0016 0.0019 0.006
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0138 0.0138
Echinococcus granulosus transcription factor btf3 0.0034 0.0137 0.0155
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0122 0.0404
Leishmania major cathepsin L-like protease 0.0034 0.0138 0.0471
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0624 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0624 0.1965
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0581 0.0658
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0115 0.013
Trypanosoma cruzi hexose transporter 0.0032 0.0124 0.042
Loa Loa (eye worm) ctsf protein 0.0034 0.0138 0.044
Trypanosoma brucei glucose transporter, putative 0.0032 0.0124 0.042
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0377 0.0414
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0294 0.4616
Echinococcus multilocularis neuropeptide receptor A26 0.046 0.2868 0.2868
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0032 0.0324
Leishmania major cathepsin L-like protease 0.0034 0.0138 0.0471
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0122 0.0404
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.1398 0.1398
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0032 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus granulosus solute carrier family 22 0.0015 0.0012 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0137 0.2045
Entamoeba histolytica hypothetical protein 0.0034 0.0137 0.3052
Schistosoma mansoni lamin 0.0026 0.0087 0.0085
Onchocerca volvulus 0.0026 0.0087 0.0241
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0117 0.1725
Onchocerca volvulus 0.0034 0.0138 0.0403
Echinococcus multilocularis cysteine protease 0.0034 0.0138 0.0138
Brugia malayi Cathepsin L-like precursor 0.0034 0.0138 0.0412
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0538 0.1692
Echinococcus multilocularis musashi 0.0026 0.0087 0.0087
Loa Loa (eye worm) cysteine protease 0.0034 0.0138 0.044
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0122 0.0122
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0025 0.0079
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0067 0.0204
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0033 0.0132 0.0132
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0067 0.0062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0138 0.0138
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0025 0.0025
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0138 0.0412
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0137 0.046
Loa Loa (eye worm) hypothetical protein 0.011 0.0624 0.1988
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0138 0.308
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0138 0.0464
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0138 0.0464
Plasmodium vivax unspecified product 0.0018 0.0032 0.0073
Brugia malayi beta-lactamase family protein 0.011 0.0624 0.1965
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0138 0.2061
Schistosoma mansoni microtubule-associated protein tau 0.1392 0.8832 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.0581 0.3201
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0067 0.0894
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0115 0.0115
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0122 0.0404
Brugia malayi MH1 domain containing protein 0.0017 0.0025 0.0051
Schistosoma mansoni hypothetical protein 0.0031 0.0115 0.0117
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0032 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0122 0.0122
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0117 0.0347
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0167 0.0989 0.3595
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0137 0.046
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0119 0.0682 0.2503
Echinococcus multilocularis vesicular acetylcholine transporter 0.0503 0.314 0.314
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0115 0.0338
Brugia malayi hypothetical protein 0.0015 0.0012 0.0009
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0124 0.1835
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0122 0.0617
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0754 0.2774
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0045 0.0208 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0124 0.1835
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0122 0.0404
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0067 0.5
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0067 0.0201
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0117 0.012
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0124 0.042
Leishmania major cathepsin L-like protease 0.0034 0.0138 0.0471
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0138 0.0471
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.1476 0.47
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0374
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0038
Echinococcus granulosus cathepsin l1 0.0023 0.0066 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0138 0.2061
Schistosoma mansoni vesicular acetylcholine transporter 0.0503 0.314 0.3546
Schistosoma mansoni hypothetical protein 0.0669 0.4206 0.4755
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0138 0.0156
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0117 0.0347
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0138 0.308
Echinococcus multilocularis solute carrier family 22 0.0015 0.0012 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0122 0.0124
Brugia malayi beta-lactamase family protein 0.011 0.0624 0.1965
Plasmodium falciparum protein kinase 7 0.0292 0.179 0.6542
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0294 0.4616
Leishmania major glucose transporter, lmgt3 0.0032 0.0124 0.042
Schistosoma mansoni protein kinase 0.0032 0.0122 0.0124
Trypanosoma brucei C-8 sterol isomerase, putative 0.0432 0.2688 1
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0137 0.0468
Schistosoma mansoni intermediate filament proteins 0.0026 0.0087 0.0085
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0015 0.0015
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0432 0.2688 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0167 0.0989 0.5495
Echinococcus multilocularis lamin dm0 0.0026 0.0087 0.0087
Brugia malayi Cathepsin L-like precursor 0.0034 0.0138 0.0412
Echinococcus granulosus metabotropic glutamate receptor 2 0.0033 0.0132 0.0149
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0624 0.0624
Brugia malayi major facilitator superfamily protein 0.0015 0.0012 0.0009
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0025 0.0015
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0048 0.0596
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0124 0.1835
Schistosoma mansoni hypothetical protein 0.0031 0.0115 0.0117
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.0754 0.2774
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0015 0.0048
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0124 0.042
Echinococcus multilocularis geminin 0.0669 0.4206 0.4206
Mycobacterium ulcerans hypothetical protein 0.011 0.0624 1
Brugia malayi Sugar transporter family protein 0.0015 0.0012 0.0009
Brugia malayi MH1 domain containing protein 0.0017 0.0025 0.0051
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0122 0.0138
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0624 0.2287

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Toxicity in mouse assessed as death up to 50 mg/kg, po up to 2 hrs ChEMBL. 18468733
Activity (ADMET) Toxicity in mouse assessed as death up to 300 mg/kg, ip after 4 hrs ChEMBL. 18468733
Activity (ADMET) Neurotoxicity in mouse at 50 mg/kg, po up to 2 hrs ChEMBL. 18468733
CC50 (functional) = 16 uM Cytotoxicity against human HSC2 cells after 24 hrs by MTT assay ChEMBL. 18468733
CC50 (functional) = 20 uM Cytotoxicity against human HL60 cells after 24 hrs by MTT assay in presence of 10% fetal bovine serum ChEMBL. 18468733
CC50 (functional) = 22 uM Cytotoxicity against human HSC4 cells after 24 hrs by MTT assay ChEMBL. 18468733
CC50 (functional) = 47 uM Cytotoxicity against human HSC3 cells after 24 hrs by MTT assay ChEMBL. 18468733
IC50 (ADMET) = 5.21 uM Cytotoxicity against human CEM cells after 72 hrs ChEMBL. 18468733
IC50 (functional) = 14 uM Cytotoxicity against mouse L1210 cells after 48 hrs ChEMBL. 18468733

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 18468733
Homo sapiens ChEMBL23 18468733

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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