Detailed information for compound 1002720

Basic information

Technical information
  • TDR Targets ID: 1002720
  • Name: NCGC00013980
  • MW: 594.697 | Formula: C36H38N2O6
  • H donors: 2 H acceptors: 2 LogP: 6.01 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc2CCN([C@H]3c2cc1Oc1c2c(CCN([C@@H]2Cc2ccc(Oc4cc(C3)ccc4O)cc2)C)cc(c1O)OC)C
  • InChi: 1S/C36H38N2O6/c1-37-13-11-23-18-31(41-3)32-20-26(23)27(37)16-22-7-10-29(39)30(17-22)43-25-8-5-21(6-9-25)15-28-34-24(12-14-38(28)2)19-33(42-4)35(40)36(34)44-32/h5-10,17-20,27-28,39-40H,11-16H2,1-4H3/t27-,28-/m1/s1
  • InChiKey: LFFQVHXIFJLJSP-VSGBNLITSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NSC-93674

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.00463533 0.0151195 0.0146891
Onchocerca volvulus 0.00501151 0.0187988 0.019914
Onchocerca volvulus 0.0096002 0.0636805 0.0687381
Schistosoma mansoni atypical protein kinase C 0.00667672 0.0350861 0.0346644
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.0187988
Schistosoma mansoni protein kinase 0.00489116 0.0176217 0.0171924
Loa Loa (eye worm) hypothetical protein 0.00666991 0.0350195 0.0350195
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni amine GPCR 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus neuropeptide Y receptor 0.00313991 0.000492846 0.000492846
Echinococcus granulosus tyrosine protein kinase Fps85D 0.00400992 0.00900238 0.00900238
Schistosoma mansoni opsin-like receptor 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Echinococcus granulosus tyrosine protein kinase Fyn 0.00761618 0.0442749 0.0442749
Onchocerca volvulus 0.00400992 0.00900238 0.00925702
Echinococcus multilocularis netrin receptor unc 5 0.00324954 0.00156514 0.00156514
Trichomonas vaginalis AGC family protein kinase 0.00592288 0.0277128 0.0244756
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00313991 0.000492846 0.000492846
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.00699077 0.0381578 0.0381578
Loa Loa (eye worm) heat shock protein 90 0.00665461 0.0348699 0.0348699
Echinococcus multilocularis tyrosine protein kinase Src42A 0.00548961 0.0234751 0.0234751
Echinococcus multilocularis dro:myosuppressin receptor 0.00313991 0.000492846 0.000492846
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0170604 0.136648 0.965006
Schistosoma mansoni serine/threonine protein kinase 0.011861 0.0857934 0.0853939
Loa Loa (eye worm) hypothetical protein 0.019874 0.164168 0.164168
Plasmodium vivax serine/threonine protein kinase 6, putative 0.105329 1 1
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.00498577 0.0185471 0.0185471
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0409826 0.370629 0.370629
Schistosoma mansoni biogenic amine (5HT) receptor 0.0409826 0.370629 0.370354
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.00761618 0.0442749 0.0442749
Entamoeba histolytica heat shock protein 90, putative 0.00665461 0.0348699 0.0316564
Brugia malayi p70 ribosomal S6 kinase beta 0.0104452 0.0719455 0.0714879
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 7 0.0150659 0.11714 0.11714
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00501151 0.0187988 0.01837
Brugia malayi hypothetical protein 0.00501151 0.0187988 0.018315
Trichomonas vaginalis CMGC family protein kinase 0.100802 0.955722 0.955574
Loa Loa (eye worm) AUR protein kinase 0.105329 1 1
Brugia malayi SRC-1 0.00761618 0.0442749 0.0438037
Loa Loa (eye worm) hypothetical protein 0.0405712 0.366606 0.366606
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Onchocerca volvulus 0.00330469 0.00210454 0.00175327
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.100802 0.955722 0.955574
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni heat shock protein 0.00665461 0.0348699 0.0344481
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus granulosus heat shock protein 90 0.00665461 0.0348699 0.0348699
Brugia malayi Protein kinase domain containing protein 0.00400992 0.00900238 0.00851373
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0345698 0.307907 0.305602
Trypanosoma cruzi Protein kinase B 0.00831818 0.0511411 0.0479818
Trypanosoma cruzi heat shock protein 85, putative 0.00665461 0.0348699 0.0316564
Brugia malayi protein unc-22 0.00330469 0.00210454 0.00161249
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus granulosus alpha 1A adrenergic receptor 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis CMGC family protein kinase 0.100802 0.955722 0.955574
Echinococcus multilocularis Protein kinase C, brain isozyme 0.00555585 0.0241229 0.0241229
Brugia malayi Serotonin/octopamine receptor family protein 7 0.019874 0.164168 0.163756
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00699077 0.0381578 0.0381578
Entamoeba histolytica cell division protein kinase 2, putative 0.076444 0.717475 0.716534
Entamoeba histolytica protein kinase domain containing protein 0.105329 1 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00501151 0.0187988 0.0187988
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis endoplasmin 0.00455904 0.0143732 0.0143732
Schistosoma mansoni serine/threonine protein kinase 0.00498577 0.0185471 0.0181182
Brugia malayi serine/threonine kinase 12 0.105329 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00313991 0.000492846 0.000492846
Brugia malayi Stress-activated protein kinase jnk-1 0.0265773 0.229732 0.229353
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0150659 0.11714 0.11714
Trypanosoma brucei heat shock protein 90, putative 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Brugia malayi Protein kinase domain containing protein 0.00600122 0.0284791 0.028
Schistosoma mansoni protein kinase 0.00847933 0.0527173 0.0523034
Echinococcus multilocularis mitogen activated protein kinase 3 0.100802 0.955722 0.955722
Echinococcus multilocularis serotonin receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00313991 0.000492846 0.0000560604
Schistosoma mansoni serine/threonine protein kinase 0.105329 1 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.00761618 0.0442749 0.0442749
Leishmania major DNA repair protein, putative 0.00593846 0.0278653 0.0246285
Echinococcus multilocularis dihydrofolate reductase 0.0175137 0.141082 0.141082
Echinococcus granulosus tyrosine protein kinase Src42A 0.00761618 0.0442749 0.0442749
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00313991 0.000492846 0.000492846
Schistosoma mansoni sodium/chloride dependent transporter 0.00501151 0.0187988 0.01837
Plasmodium vivax protein kinase Crk2 0.076444 0.717475 0.716534
Echinococcus granulosus fmrfamide receptor 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis AGC family protein kinase 0.105329 1 1
Brugia malayi Dihydrofolate reductase 0.0175137 0.141082 0.140659
Loa Loa (eye worm) AGC/PKN protein kinase 0.00555585 0.0241229 0.0241229
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00313991 0.000492846 0.0000560604
Trypanosoma cruzi heat shock protein 85, putative 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) hypothetical protein 0.0733823 0.687528 0.687528
Echinococcus granulosus somatostatin receptor 0.00313991 0.000492846 0.000492846
Treponema pallidum sodium- and chloride- dependent transporter 0.0295223 0.258537 1
Trichomonas vaginalis AGC family protein kinase 0.0108122 0.0755354 0.0724574
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.00501151 0.0187988 0.0187988
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.100802 0.955722 0.955574
Echinococcus multilocularis c src tyrosine kinase 0.00463533 0.0151195 0.0151195
Entamoeba histolytica heat shock protein 90, putative 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) neuropeptide F receptor 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00313991 0.000492846 0.000492846
Brugia malayi serine/threonine-protein kinase plk-2 0.0133827 0.100677 0.100234
Loa Loa (eye worm) AGC/NDR protein kinase 0.00555585 0.0241229 0.0241229
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0158884 0.125185 0.122272
Schistosoma mansoni tankyrase 0.00466613 0.0154207 0.0149904
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.00555585 0.0241229 0.0241229
Trichomonas vaginalis STE family protein kinase 0.0109512 0.0768946 0.073821
Loa Loa (eye worm) dihydrofolate reductase 0.0175137 0.141082 0.141082
Loa Loa (eye worm) hypothetical protein 0.00555585 0.0241229 0.0241229
Echinococcus granulosus acetylcholinesterase 0.00666991 0.0350195 0.0350195
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.00361478 0.00513756 0.00513756
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00501151 0.0187988 0.01837
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00313991 0.000492846 0.0000560604
Schistosoma mansoni serine/threonine protein kinase 0.00555585 0.0241229 0.0236965
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.00498577 0.0185471 0.0185471
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.0187988
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.018315
Trichomonas vaginalis CAMK family protein kinase 0.0133827 0.100677 0.0976826
Echinococcus granulosus tankyrase 0.00466613 0.0154207 0.0154207
Entamoeba histolytica protein kinase, putative 0.0108122 0.0755354 0.0724574
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.00555585 0.0241229 0.0241229
Echinococcus granulosus twitchin 0.0058412 0.026914 0.026914
Brugia malayi Endoplasmin precursor 0.00665461 0.0348699 0.034394
Loa Loa (eye worm) CAMK protein kinase 0.00330469 0.00210454 0.00210454
Trypanosoma brucei cdc2-related kinase 1 0.076444 0.717475 0.716534
Echinococcus granulosus poly (ADP ribose) polymerase 0.00977245 0.0653653 0.0653653
Echinococcus multilocularis sex peptide receptor 0.00313991 0.000492846 0.000492846
Echinococcus granulosus tyrosine protein kinase Src42A 0.00548961 0.0234751 0.0234751
Brugia malayi hypothetical protein 0.00400992 0.00900238 0.00851373
Echinococcus multilocularis activin receptor type 0.00489116 0.0176217 0.0176217
Schistosoma mansoni serine/threonine-protein kinase 0.00831818 0.0511411 0.0507264
Echinococcus granulosus 3'partial|mitogen activated protein kinase kinase kinase 0.0150659 0.11714 0.11714
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.100802 0.955722 0.955574
Echinococcus granulosus neuropeptide FF receptor 2 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) neuropeptide F receptor 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis mitogen activated protein kinase 11 0.0158884 0.125185 0.125185
Schistosoma mansoni tyrosine kinase 0.0305588 0.268675 0.268355
Trichomonas vaginalis AGC family protein kinase 0.0108122 0.0755354 0.0724574
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Brugia malayi protein-tyrosine kinase 0.00699077 0.0381578 0.0376835
Entamoeba histolytica hypothetical protein 0.00977245 0.0653653 0.0622533
Echinococcus granulosus rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.013999 0.106705 0.106705
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.00811611 0.0491647 0.0459989
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Trypanosoma brucei C-8 sterol isomerase, putative 0.040085 0.36185 0.359725
Schistosoma mansoni neuropeptide F-like receptor 0.00313991 0.000492846 0.0000560604
Echinococcus multilocularis tyrosine protein kinase Abl 0.00463533 0.0151195 0.0151195
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0237568 0.202145 0.199489
Echinococcus multilocularis nervana 2 0.00488937 0.0176042 0.0176042
Loa Loa (eye worm) hypothetical protein 0.0345698 0.307907 0.307907
Schistosoma mansoni protein kinase 0.00489116 0.0176217 0.0171924
Trichomonas vaginalis AGC family protein kinase 0.105329 1 1
Loa Loa (eye worm) hypothetical protein 0.00501151 0.0187988 0.0187988
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0345698 0.307907 0.305602
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Brugia malayi Protein kinase domain containing protein 0.076444 0.717475 0.717336
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.00555585 0.0241229 0.0241229
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Schistosoma mansoni dihydrofolate reductase 0.0175137 0.141082 0.140707
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.00593846 0.0278653 0.0246285
Echinococcus granulosus heat shock protein 0.00665461 0.0348699 0.0348699
Echinococcus multilocularis protein kinase c epsilon type 0.00555585 0.0241229 0.0241229
Leishmania major protein kinase, putative 0.00489116 0.0176217 0.0143508
Trichomonas vaginalis AGC family protein kinase 0.00555585 0.0241229 0.0208737
Entamoeba histolytica serine/threonine protein kinase, putative 0.0133827 0.100677 0.0976826
Echinococcus granulosus cyclin dependent kinase 0.076444 0.717475 0.717475
Schistosoma mansoni neuropeptide receptor 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni hypothetical protein 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus neuropeptide s receptor 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis g protein coupled receptor 0.00313991 0.000492846 0.000492846
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0046679 0.015438 0.0121598
Schistosoma mansoni serine/threonine protein kinase 0.00555585 0.0241229 0.0236965
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00501151 0.0187988 0.01837
Onchocerca volvulus 0.00400992 0.00900238 0.00925702
Trichomonas vaginalis CAMK family protein kinase 0.0133827 0.100677 0.0976826
Echinococcus granulosus dual specificity testis-specific protein kinase 0.00489116 0.0176217 0.0176217
Echinococcus multilocularis serine threonine protein kinase 0.00555585 0.0241229 0.0241229
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni serine/threonine protein kinase 0.076444 0.717475 0.717352
Loa Loa (eye worm) hypothetical protein 0.00501151 0.0187988 0.0187988
Echinococcus granulosus neuropeptide receptor 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis nervana 2 0.00488937 0.0176042 0.0176042
Entamoeba histolytica protein kinase, putative 0.0108122 0.0755354 0.0724574
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0109512 0.0768946 0.0764394
Echinococcus multilocularis kinase protein 0.0150659 0.11714 0.11714
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0247974 0.212323 0.212323
Mycobacterium ulcerans thymidylate synthase 0.0170604 0.136648 0.965006
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00501151 0.0187988 0.0187988
Echinococcus granulosus tyrosine protein kinase Fyn 0.00761618 0.0442749 0.0442749
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0573075 0.530302 0.528738
Trichomonas vaginalis CMGC family protein kinase 0.076444 0.717475 0.716534
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis serine:threonine protein kinase N2 0.00555585 0.0241229 0.0241229
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Brugia malayi Protein kinase domain containing protein 0.00555585 0.0241229 0.0236418
Echinococcus granulosus titin 0.00330469 0.00210454 0.00210454
Trypanosoma cruzi cdc2-related kinase 1 0.076444 0.717475 0.716534
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Echinococcus granulosus aurora kinase A 0.105329 1 1
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0451593 0.411481 0.411481
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00501151 0.0187988 0.01837
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0175137 0.141082 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus tm gpcr rhodopsin 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis orexin receptor type 2 0.00313991 0.000492846 0.000492846
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0181958 0.147753 0.147753
Brugia malayi WGR domain containing protein 0.0345698 0.307907 0.307565
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Echinococcus granulosus NDR protein kinase 0.00555585 0.0241229 0.0241229
Echinococcus multilocularis neuropeptide receptor 0.00313991 0.000492846 0.000492846
Plasmodium vivax endoplasmin, putative 0.00665461 0.0348699 0.0316564
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.00489116 0.0176217 0.0143508
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.00489116 0.0176217 0.0143508
Loa Loa (eye worm) hypothetical protein 0.0295223 0.258537 0.258537
Toxoplasma gondii hypothetical protein 0.00501151 0.0187988 0.0155319
Schistosoma mansoni serine/threonine protein kinase 0.076444 0.717475 0.717352
Echinococcus granulosus g protein coupled receptor 0.00313991 0.000492846 0.000492846
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Schistosoma mansoni serine/threonine protein kinase 0.100802 0.955722 0.955702
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.00501151 0.0187988 0.0187988
Schistosoma mansoni tyrosine kinase 0.00761618 0.0442749 0.0438573
Trypanosoma brucei aurora B kinase 0.105329 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0133827 0.100677 0.0976826
Trichomonas vaginalis heat shock protein, putative 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis serotonin receptor 0.00313991 0.000492846 0.000492846
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0175137 0.141082 1
Schistosoma mansoni pyruvate dehydrogenase 0.013999 0.106705 0.106315
Entamoeba histolytica hypothetical protein 0.00466613 0.0154207 0.0121425
Loa Loa (eye worm) hypothetical protein 0.026827 0.232174 0.232174
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00313991 0.000492846 0.000492846
Brugia malayi Carboxylesterase family protein 0.00666991 0.0350195 0.0345437
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.00455904 0.0143732 0.0143732
Echinococcus granulosus titin 0.00330469 0.00210454 0.00210454
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.00498577 0.0185471 0.0185471
Plasmodium vivax heat shock protein 86, putative 0.00665461 0.0348699 0.0316564
Plasmodium falciparum transporter, putative 0.00501151 0.0187988 0.0155319
Echinococcus granulosus serotonin transporter 0.0295223 0.258537 0.258537
Trypanosoma brucei poly(adp-ribose) polymerase 0.0345698 0.307907 0.305602
Echinococcus granulosus serine:threonine protein kinase N2 0.00555585 0.0241229 0.0241229
Echinococcus granulosus serine threonine protein kinase nrc 0.00795115 0.0475512 0.0475512
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0170604 0.136648 0.136271
Brugia malayi probable protein kinase 0.00498577 0.0185471 0.0180632
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00761618 0.0442749 0.0442749
Trichomonas vaginalis heat shock protein, putative 0.00454749 0.0142603 0.0109783
Echinococcus multilocularis heat shock protein 90 0.00665461 0.0348699 0.0348699
Echinococcus granulosus orexin receptor type 2 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis heat shock protein, putative 0.00455904 0.0143732 0.0110915
Echinococcus multilocularis neuropeptide s receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00501151 0.0187988 0.01837
Schistosoma mansoni tyrosine kinase 0.0474233 0.433625 0.433377
Brugia malayi MAP kinase sur-1 0.100802 0.955722 0.9557
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Trypanosoma cruzi heat shock protein 85, putative 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis carboxylesterase 5A 0.00666991 0.0350195 0.0350195
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Echinococcus granulosus poly adp ribose polymerase 2 0.0345698 0.307907 0.307907
Loa Loa (eye worm) hypothetical protein 0.013999 0.106705 0.106705
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Trypanosoma cruzi heat shock protein 90, putative 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis rac serine:threonine kinase 0.00831818 0.0511411 0.0511411
Brugia malayi dihydrofolate reductase family protein 0.0175137 0.141082 0.140659
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.076444 0.717475 0.717475
Loa Loa (eye worm) hypothetical protein 0.00666991 0.0350195 0.0350195
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Brugia malayi Protein kinase domain containing protein 0.00498577 0.0185471 0.0180632
Trypanosoma cruzi cdc2-related kinase 3 0.076444 0.717475 0.716534
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0115638 0.0828867 0.0828867
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.00555585 0.0241229 0.0241229
Schistosoma mansoni kinase 0.00841731 0.0521107 0.0516965
Trypanosoma brucei DNA repair protein, putative 0.00593846 0.0278653 0.0246285
Schistosoma mansoni sodium/chloride dependent transporter 0.0295223 0.258537 0.258213
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.00498577 0.0185471 0.0185471
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.076444 0.717475 0.717475
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Giardia lamblia Kinase, CMGC CDK 0.076444 0.717475 0.713355
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.019874 0.164168 0.163803
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.00489116 0.0176217 0.0143508
Entamoeba histolytica protein kinase domain containing protein 0.00489116 0.0176217 0.0143508
Schistosoma mansoni tyrosine kinase 0.00761618 0.0442749 0.0438573
Trypanosoma cruzi cdc2-related kinase 3 0.076444 0.717475 0.716534
Leishmania major hypothetical protein, conserved 0.00593846 0.0278653 0.0246285
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0265773 0.229732 0.229732
Loa Loa (eye worm) acetylcholinesterase 1 0.00666991 0.0350195 0.0350195
Brugia malayi ERG2 and Sigma1 receptor like protein 0.040085 0.36185 0.361535
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00313991 0.000492846 0.0000560604
Trichomonas vaginalis CMGC family protein kinase 0.100802 0.955722 0.955574
Loa Loa (eye worm) SRC-1 0.00761618 0.0442749 0.0442749
Schistosoma mansoni hypothetical protein 0.00313991 0.000492846 0.0000560604
Schistosoma mansoni amine GPCR 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0138335 0.105086 0.105086
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00501151 0.0187988 0.01837
Schistosoma mansoni neuropeptide receptor 0.00313991 0.000492846 0.0000560604
Brugia malayi Protein kinase domain containing protein 0.097124 0.919744 0.919705
Schistosoma mansoni serine/threonine protein kinase 0.0133827 0.100677 0.100284
Echinococcus multilocularis NCK adaptor protein 0.00313418 0.00043681 0.00043681
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.100802 0.955722 0.955574
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00501151 0.0187988 0.0187988
Echinococcus granulosus netrin receptor unc 5 0.00324954 0.00156514 0.00156514
Giardia lamblia Kinase, PLK 0.0133827 0.100677 0.0875623
Echinococcus granulosus nervana 2 0.00488937 0.0176042 0.0176042
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0187853 0.153519 0.153519
Brugia malayi Immunoglobulin I-set domain containing protein 0.00324954 0.00156514 0.00107282
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Trypanosoma cruzi heat shock protein 90, putative 0.00455904 0.0143732 0.0110915
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Brugia malayi Protein kinase domain containing protein 0.00400992 0.00900238 0.00851373
Echinococcus granulosus protein tyrosine kinase 0.0305588 0.268675 0.268675
Echinococcus multilocularis g-protein coupled receptor 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00761618 0.0442749 0.0442749
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0555961 0.513563 0.513563
Brugia malayi P38 map kinase family protein 2 0.0158884 0.125185 0.124754
Loa Loa (eye worm) hypothetical protein 0.0295223 0.258537 0.258537
Loa Loa (eye worm) AUR protein kinase 0.105329 1 1
Echinococcus granulosus hypothetical protein 0.074138 0.69492 0.69492
Loa Loa (eye worm) TK protein kinase 0.00699077 0.0381578 0.0381578
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.076444 0.717475 0.716534
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.100802 0.955722 0.955574
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis AGC family protein kinase 0.00555585 0.0241229 0.0208737
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.00501151 0.0187988 0.018315
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0237568 0.202145 0.199489
Entamoeba histolytica protein kinase, putative 0.105329 1 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0158884 0.125185 0.122272
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.00761618 0.0442749 0.0442749
Loa Loa (eye worm) TKL/MLK/MLK protein kinase 0.00339001 0.00293902 0.00293902
Echinococcus granulosus acetylcholinesterase 0.00666991 0.0350195 0.0350195
Schistosoma mansoni opsin-like receptor 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni tyrosine kinase 0.00463533 0.0151195 0.0146891
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00313991 0.000492846 0.000492846
Echinococcus granulosus neuropeptide receptor 0.0338732 0.301093 0.301093
Echinococcus multilocularis cyclin dependent kinase 1 0.076444 0.717475 0.717475
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis tyrosine kinase 0.00400992 0.00900238 0.00900238
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0163569 0.129768 0.910704
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00761618 0.0442749 0.0442749
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.105329 1 1
Trypanosoma cruzi DNA repair protein, putative 0.00593846 0.0278653 0.0246285
Schistosoma mansoni serine/threonine protein kinase 0.00555585 0.0241229 0.0236965
Brugia malayi Hr1 repeat family protein 0.00555585 0.0241229 0.0236418
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.013999 0.106705 0.106705
Loa Loa (eye worm) hypothetical protein 0.00593846 0.0278653 0.0278653
Onchocerca volvulus 0.00400992 0.00900238 0.00925702
Brugia malayi Protein kinase domain containing protein 0.0108122 0.0755354 0.0750796
Schistosoma mansoni tyrosine kinase 0.00463533 0.0151195 0.0146891
Trypanosoma brucei Heat shock protein 83, putative 0.00665461 0.0348699 0.0316564
Schistosoma mansoni biogenic amine receptor 0.00313991 0.000492846 0.0000560604
Entamoeba histolytica protein kinase, putative 0.00524231 0.0210562 0.0177968
Leishmania major developmentally regulated phosphoprotein-like protein 0.013999 0.106705 0.103731
Loa Loa (eye worm) thymidylate synthase 0.0170604 0.136648 0.136648
Brugia malayi Protein kinase domain containing protein 0.0096002 0.0636805 0.0632188
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Brugia malayi Protein kinase domain containing protein 0.0138335 0.105086 0.104645
Echinococcus multilocularis mitogen activated protein kinase 0.100802 0.955722 0.955722
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0158884 0.125185 0.125185
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00313991 0.000492846 0.000492846
Echinococcus granulosus Glutaredoxin protein 5 0.00488937 0.0176042 0.0176042
Schistosoma mansoni serine/threonine protein kinase 0.00498577 0.0185471 0.0181182
Giardia lamblia Aurora kinase 0.105329 1 1
Onchocerca volvulus 0.00400992 0.00900238 0.00925702
Toxoplasma gondii hypothetical protein 0.00501151 0.0187988 0.0155319
Echinococcus multilocularis tyrosine protein kinase Blk 0.00699077 0.0381578 0.0381578
Echinococcus multilocularis serine:threonine protein kinase 38 0.00555585 0.0241229 0.0241229
Echinococcus multilocularis heat shock protein 90 0.00455904 0.0143732 0.0143732
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0144386 0.111004 0.111004
Echinococcus granulosus 5'partial|3'partial|mitogen activated protein kinase kinase kinase 0.0150659 0.11714 0.11714
Echinococcus multilocularis neuropeptides capa receptor 0.00313991 0.000492846 0.000492846
Echinococcus granulosus G protein coupled receptor 139 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis CAMK family protein kinase 0.00802718 0.0482948 0.0451261
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0138335 0.105086 0.105086
Brugia malayi kinase, mitochondrial precursor 0.013999 0.106705 0.106265
Brugia malayi Protein kinase domain containing protein 0.00555585 0.0241229 0.0236418
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Echinococcus granulosus growth factor receptor bound protein 2 0.00313418 0.00043681 0.00043681
Leishmania major C-8 sterol isomerase-like protein 0.040085 0.36185 0.359725
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.00418264 0.0106918 0.0106918
Echinococcus multilocularis fmrfamide receptor 0.00313991 0.000492846 0.000492846
Brugia malayi WGR domain containing protein 0.0555961 0.513563 0.513323
Plasmodium falciparum protein kinase 5 0.076444 0.717475 0.716534
Trichomonas vaginalis AGC family protein kinase 0.0108122 0.0755354 0.0724574
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis neuropeptide receptor 0.0338732 0.301093 0.301093
Schistosoma mansoni endoplasmin 0.00665461 0.0348699 0.0344481
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis dual specificity mitogen activated protein 0.0109512 0.0768946 0.0768946
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.0155319
Schistosoma mansoni amine GPCR 0.00313991 0.000492846 0.0000560604
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0883376 0.833805 0.833805
Schistosoma mansoni sodium-dependent amino acid transporter 0.00501151 0.0187988 0.01837
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus granulosus c src tyrosine kinase 0.00463533 0.0151195 0.0151195
Echinococcus multilocularis tankyrase 0.00466613 0.0154207 0.0154207
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.00761618 0.0442749 0.0442749
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus neuropeptide Y receptor 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0150659 0.11714 0.11714
Trichomonas vaginalis AGC family protein kinase 0.0108122 0.0755354 0.0724574
Echinococcus granulosus c-Jun N-terminal kinases 0.0265773 0.229732 0.229732
Chlamydia trachomatis dihydrofolate reductase 0.0175137 0.141082 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00666991 0.0350195 0.0345978
Echinococcus granulosus biogenic amine 5HT receptor 0.0409826 0.370629 0.370629
Echinococcus granulosus protein kinase c epsilon type 0.00555585 0.0241229 0.0241229
Loa Loa (eye worm) TK/ABL protein kinase 0.00400992 0.00900238 0.00900238
Echinococcus granulosus tm gpcr rhodopsin 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis STE family protein kinase 0.0109512 0.0768946 0.073821
Loa Loa (eye worm) hypothetical protein 0.00501151 0.0187988 0.0187988
Trichomonas vaginalis AGC family protein kinase 0.0108122 0.0755354 0.0724574
Echinococcus multilocularis acetylcholinesterase 0.00666991 0.0350195 0.0350195
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Brugia malayi heat shock protein 90 0.00665461 0.0348699 0.034394
Echinococcus granulosus dro:myosuppressin receptor 0.00313991 0.000492846 0.000492846
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0133827 0.100677 0.100677
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0237568 0.202145 0.199489
Toxoplasma gondii aurora kinase 0.105329 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Brugia malayi protein kinase C II. 0.00555585 0.0241229 0.0236418
Trichomonas vaginalis CAMK family protein kinase 0.0133827 0.100677 0.0976826
Echinococcus granulosus rho-associated protein kinase 1 0.0156658 0.123007 0.123007
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) hypothetical protein 0.0205832 0.171104 0.171104
Schistosoma mansoni sodium/chloride dependent transporter 0.00807328 0.0487458 0.0483301
Trypanosoma cruzi polo-like protein kinase, putative 0.0133827 0.100677 0.0976826
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.00676347 0.0359346 0.0327247
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0345698 0.307907 0.307907
Echinococcus multilocularis mitogen activated protein kinase 11 0.0158884 0.125185 0.125185
Trypanosoma cruzi Heat shock protein 83, putative 0.00665461 0.0348699 0.0316564
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.105329 1 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.00847933 0.0527173 0.0527173
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.00555585 0.0241229 0.0241229
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.100802 0.955722 0.955722
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0109512 0.0768946 0.073821
Onchocerca volvulus 0.00400992 0.00900238 0.00925702
Brugia malayi Protein kinase domain containing protein 0.00400992 0.00900238 0.00851373
Brugia malayi Carboxylesterase family protein 0.00666991 0.0350195 0.0345437
Schistosoma mansoni protein kinase 0.00498577 0.0185471 0.0181182
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni tyrosine kinase 0.0452427 0.412297 0.412041
Echinococcus granulosus tyrosine kinase 0.00699077 0.0381578 0.0381578
Loa Loa (eye worm) tnks protein 0.00466613 0.0154207 0.0154207
Echinococcus multilocularis G-protein coupled receptor, putative 0.00313991 0.000492846 0.000492846
Giardia lamblia Kinase, CMGC MAPK 0.100802 0.955722 0.955076
Echinococcus multilocularis kinase protein 0.0150659 0.11714 0.11714
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0150659 0.11714 0.11714
Echinococcus granulosus WGR domain containing protein 0.0195449 0.160949 0.160949
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0170604 0.136648 0.965006
Trypanosoma brucei cdc2-related kinase 3 0.076444 0.717475 0.716534
Toxoplasma gondii AGC kinase 0.0104452 0.0719455 0.0688555
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00501151 0.0187988 0.0187988
Trichomonas vaginalis CAMK family protein kinase 0.00802718 0.0482948 0.0451261
Onchocerca volvulus 0.00501151 0.0187988 0.019914
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni titin 0.00330469 0.00210454 0.00166846
Trichomonas vaginalis AGC family protein kinase 0.0108122 0.0755354 0.0724574
Trypanosoma brucei developmentally regulated phosphoprotein 0.013999 0.106705 0.103731
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Brugia malayi serine/threonine protein kinase 6 0.105329 1 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.00761618 0.0442749 0.0442749
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.00488937 0.0176042 0.0176042
Plasmodium vivax hypothetical protein, conserved 0.00501151 0.0187988 0.0155319
Giardia lamblia Kinase, AGC PKA 0.00795115 0.0475512 0.0336618
Echinococcus granulosus carboxylesterase 5A 0.00666991 0.0350195 0.0350195
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus poly (ADP ribose) polymerase 0.00977245 0.0653653 0.0653653
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Echinococcus granulosus tyrosine protein kinase Src64B 0.00761618 0.0442749 0.0442749
Brugia malayi Protein kinase domain containing protein 0.00400992 0.00900238 0.00851373
Entamoeba histolytica protein kinase, putative 0.105329 1 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.00481023 0.0168302 0.0168302
Echinococcus granulosus serine/threonine protein kinase 0.00831818 0.0511411 0.0511411
Echinococcus granulosus tm gpcr rhodopsin 0.0883376 0.833805 0.833805
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Echinococcus multilocularis thymidylate synthase 0.0170604 0.136648 0.136648
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Entamoeba histolytica protein kinase, putative 0.0104452 0.0719455 0.0688555
Echinococcus granulosus tyrosine protein kinase Fyn 0.00761618 0.0442749 0.0442749
Echinococcus multilocularis serotonin transporter 0.0295223 0.258537 0.258537
Onchocerca volvulus 0.00400992 0.00900238 0.00925702
Schistosoma mansoni serine/threonine protein kinase 0.00555585 0.0241229 0.0236965
Onchocerca volvulus 0.00368719 0.00584573 0.00582309
Schistosoma mansoni heat shock protein 0.00665461 0.0348699 0.0344481
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0175137 0.141082 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.00455904 0.0143732 0.0110915
Trypanosoma cruzi rac serine-threonine kinase, putative 0.00831818 0.0511411 0.0479818
Echinococcus granulosus sodium and chloride dependent glycine 0.00501151 0.0187988 0.0187988
Echinococcus multilocularis mitogen activated protein kinase 14 0.0158884 0.125185 0.125185
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0295223 0.258537 0.258213
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.018315
Brugia malayi serine/threonine-protein kinase 6 0.105329 1 1
Echinococcus granulosus allatostatin A receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Onchocerca volvulus 0.0141093 0.107784 0.116716
Loa Loa (eye worm) TK/FAK protein kinase 0.030928 0.272286 0.272286
Echinococcus granulosus neuropeptide receptor A26 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis AGC family protein kinase 0.0108122 0.0755354 0.0724574
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.076444 0.717475 0.717475
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0046679 0.015438 0.0121598
Echinococcus multilocularis serine:threonine protein kinase N2 0.00555585 0.0241229 0.0241229
Echinococcus multilocularis neuropeptide Y receptor 0.00313991 0.000492846 0.000492846
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0109512 0.0768946 0.073821
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0109512 0.0768946 0.0768946
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.076444 0.717475 0.716534
Giardia lamblia Heat shock protein HSP 90-alpha 0.00665461 0.0348699 0.0207955
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.00501151 0.0187988 0.0187988
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.0155319
Echinococcus multilocularis titin 0.00330469 0.00210454 0.00210454
Echinococcus multilocularis allatostatin A receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni adenoreceptor 0.00313991 0.000492846 0.0000560604
Echinococcus multilocularis g protein coupled receptor 0.00313991 0.000492846 0.000492846
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.105329 1 1
Echinococcus granulosus g protein coupled receptor 0.00313991 0.000492846 0.000492846
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0237568 0.202145 0.199489
Schistosoma mansoni myosin xvIII 0.00313991 0.000492846 0.0000560604
Onchocerca volvulus 0.0170604 0.136648 0.148115
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.00555585 0.0241229 0.0241229
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00501151 0.0187988 0.01837
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) hypothetical protein 0.0295223 0.258537 0.258537
Echinococcus multilocularis sodium and chloride dependent glycine 0.00501151 0.0187988 0.0187988
Echinococcus multilocularis g protein coupled receptor 0.00313991 0.000492846 0.000492846
Brugia malayi SH2 domain containing protein 0.00400992 0.00900238 0.00851373
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis rho associated protein kinase 0.0156658 0.123007 0.123007
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.076444 0.717475 0.717475
Echinococcus granulosus mitogen activated protein kinase 11 0.0158884 0.125185 0.125185
Echinococcus multilocularis somatostatin receptor 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis sodium and chloride dependent glycine 0.00501151 0.0187988 0.0187988
Trypanosoma cruzi cdc2-related kinase 1 0.076444 0.717475 0.716534
Onchocerca volvulus 0.0156658 0.123007 0.133276
Onchocerca volvulus 0.00501151 0.0187988 0.019914
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus Protein kinase C brain isozyme 0.00555585 0.0241229 0.0241229
Schistosoma mansoni neuropeptide receptor 0.00313991 0.000492846 0.0000560604
Echinococcus multilocularis cyclin dependent kinase 0.076444 0.717475 0.717475
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Echinococcus multilocularis mitogen activated protein kinase 14 0.0158884 0.125185 0.125185
Echinococcus granulosus rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0181958 0.147753 0.147753
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis AGC family protein kinase 0.105329 1 1
Echinococcus granulosus mitogen activated protein kinase 0.100802 0.955722 0.955722
Mycobacterium ulcerans epoxide hydrolase EphA 0.0163569 0.129768 0.910704
Entamoeba histolytica SH2-protein kinase domain containing protein 0.00400992 0.00900238 0.0057028
Echinococcus granulosus cyclin dependent kinase 1 0.076444 0.717475 0.717475
Echinococcus granulosus dual specificity mitogen activated protein 0.0109512 0.0768946 0.0768946
Trypanosoma brucei protein kinase, putative 0.100802 0.955722 0.955574
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.00795115 0.0475512 0.04438
Echinococcus granulosus neuropeptides capa receptor 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0104452 0.0719455 0.0719455
Schistosoma mansoni pyruvate dehydrogenase 0.0119034 0.0862084 0.0858091
Plasmodium falciparum protein kinase, putative 0.00489116 0.0176217 0.0143508
Echinococcus multilocularis twitchin 0.00330469 0.00210454 0.00210454
Onchocerca volvulus 0.012604 0.0930604 0.100699
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.00330469 0.00210454 0.00210454
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.00498577 0.0185471 0.0185471
Trichomonas vaginalis CMGC family protein kinase 0.076444 0.717475 0.716534
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.013999 0.106705 0.103731
Schistosoma mansoni tyrosine kinase 0.0178986 0.144847 0.144473
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Schistosoma mansoni serine/threonine protein kinase 0.00555585 0.0241229 0.0236965
Trypanosoma cruzi heat shock protein 90, putative 0.00420268 0.0108878 0.00759449
Schistosoma mansoni biogenic amine receptor 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus tyrosine protein kinase Srms 0.00400992 0.00900238 0.00900238
Echinococcus granulosus tyrosine protein kinase HCK 0.00481023 0.0168302 0.0168302
Brugia malayi Immunoglobulin I-set domain containing protein 0.00330469 0.00210454 0.00161249
Trichomonas vaginalis heat shock protein, putative 0.00455904 0.0143732 0.0110915
Schistosoma mansoni netrin receptor unc5 0.00324954 0.00156514 0.00112882
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0555961 0.513563 0.513351
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00313991 0.000492846 0.000492846
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Schistosoma mansoni biogenic amine (5HT) receptor 0.00313991 0.000492846 0.0000560604
Trichomonas vaginalis STE family protein kinase 0.0109512 0.0768946 0.073821
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Schistosoma mansoni serine/threonine-protein kinase 0.00831818 0.0511411 0.0507264
Brugia malayi Protein kinase domain containing protein 0.00400992 0.00900238 0.00851373
Echinococcus granulosus dihydrofolate reductase 0.0175137 0.141082 0.141082
Schistosoma mansoni serine/threonine kinase 0.00555585 0.0241229 0.0236965
Echinococcus granulosus g protein coupled receptor 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis AGC family protein kinase 0.00555585 0.0241229 0.0208737
Trichomonas vaginalis CAMK family protein kinase 0.0133827 0.100677 0.0976826
Giardia lamblia Kinase, CMGC CDK 0.076444 0.717475 0.713355
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0158884 0.125185 0.122272
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.00555585 0.0241229 0.0241229
Echinococcus multilocularis G protein coupled receptor 139 0.0338732 0.301093 0.301093
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.100802 0.955722 0.955574
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0345698 0.307907 0.307604
Echinococcus granulosus tyrosine kinase 0.00400992 0.00900238 0.00900238
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.00498577 0.0185471 0.0185471
Echinococcus granulosus poly (ADP ribose) polymerase 0.0195449 0.160949 0.160949
Brugia malayi Tyrosine-protein kinase abl-1 0.00463533 0.0151195 0.0146339
Brugia malayi thymidylate synthase 0.0170604 0.136648 0.136222
Echinococcus granulosus protein kinase c iota type 0.00555585 0.0241229 0.0241229
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.00501151 0.0187988 0.0187988
Toxoplasma gondii heat shock protein HSP90 0.00665461 0.0348699 0.0316564
Echinococcus granulosus tyrosine protein kinase ABL1 0.00400992 0.00900238 0.00900238
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0295223 0.258537 0.258172
Echinococcus multilocularis neuropeptide FF receptor 2 0.00313991 0.000492846 0.000492846
Entamoeba histolytica hypothetical protein 0.00466613 0.0154207 0.0121425
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.00501151 0.0187988 0.0187988
Echinococcus multilocularis cyclin dependent kinase 1 0.076444 0.717475 0.717475
Entamoeba histolytica PH domain containing protein kinase, putative 0.00831818 0.0511411 0.0479818
Loa Loa (eye worm) hypothetical protein 0.00501151 0.0187988 0.0187988
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni opsin-like receptor 0.00313991 0.000492846 0.0000560604
Trypanosoma cruzi aurora B kinase, putative 0.105329 1 1
Loa Loa (eye worm) endoplasmin 0.00665461 0.0348699 0.0348699
Entamoeba histolytica hypothetical protein 0.00466613 0.0154207 0.0121425
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.018315
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.105329 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) serotonin transporter b 0.0295223 0.258537 0.258537
Loa Loa (eye worm) G-protein coupled receptor 0.00313991 0.000492846 0.000492846
Plasmodium falciparum endoplasmin, putative 0.00454749 0.0142603 0.0109783
Echinococcus granulosus 7TM GPCR rhodopsin 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.019874 0.164168 0.164168
Echinococcus granulosus calcium activated potassium channel 0.00343377 0.00336708 0.00336708
Echinococcus granulosus protein kinase C gamma type 0.00555585 0.0241229 0.0241229
Echinococcus multilocularis heat shock protein 0.00665461 0.0348699 0.0348699
Schistosoma mansoni histamine h1 receptor 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.00761618 0.0442749 0.0442749
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0265773 0.229732 0.229732
Brugia malayi Tnks protein 0.00466613 0.0154207 0.0149352
Loa Loa (eye worm) carboxylesterase 0.00666991 0.0350195 0.0350195
Echinococcus granulosus tyrosine protein kinase Lyn 0.010678 0.0742219 0.0742219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Echinococcus multilocularis dual specificity testis specific protein kinase 0.00489116 0.0176217 0.0176217
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Echinococcus multilocularis tyrosine protein kinase shark 0.0474233 0.433625 0.433625
Entamoeba histolytica hypothetical protein 0.00466613 0.0154207 0.0121425
Echinococcus granulosus serine:threonine protein kinase 12 B 0.105329 1 1
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0046679 0.015438 0.0121598
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0046679 0.015438 0.0121598
Echinococcus multilocularis acetylcholinesterase 0.00666991 0.0350195 0.0350195
Schistosoma mansoni serine/threonine protein kinase 0.00330469 0.00210454 0.00166846
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0237568 0.202145 0.199489
Trichomonas vaginalis CAMK family protein kinase 0.0133827 0.100677 0.0976826
Echinococcus granulosus g-protein coupled receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00313991 0.000492846 0.0000560604
Onchocerca volvulus Tyrosine kinase homolog 0.0161816 0.128053 0.138765
Schistosoma mansoni protein kinase 0.105329 1 1
Loa Loa (eye worm) TK protein kinase 0.00481023 0.0168302 0.0168302
Trypanosoma cruzi heat shock protein 85, putative 0.00455904 0.0143732 0.0110915
Loa Loa (eye worm) AUR protein kinase 0.105329 1 1
Schistosoma mansoni serine/threonine protein kinase 0.00555585 0.0241229 0.0236965
Entamoeba histolytica protein kinase 2, putative 0.00795115 0.0475512 0.04438
Echinococcus multilocularis neuropeptides capa receptor 0.00313991 0.000492846 0.000492846
Onchocerca volvulus Serine\/threonine kinase homolog 0.0133827 0.100677 0.108985
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00313991 0.000492846 0.000492846
Schistosoma mansoni serine/threonine protein kinase 0.0265773 0.229732 0.229396
Echinococcus multilocularis Glutaredoxin protein 5 0.00488937 0.0176042 0.0176042
Trichomonas vaginalis heat shock protein, putative 0.00455904 0.0143732 0.0110915
Echinococcus multilocularis neuropeptide receptor A26 0.00313991 0.000492846 0.000492846
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.00488937 0.0176042 0.0176042
Entamoeba histolytica zinc finger protein, putative 0.00466613 0.0154207 0.0121425
Echinococcus granulosus cyclin dependent kinase 5 0.076444 0.717475 0.717475
Loa Loa (eye worm) hypothetical protein 0.00400992 0.00900238 0.00900238
Echinococcus multilocularis conserved hypothetical protein 0.0709981 0.664208 0.664208
Schistosoma mansoni neuropeptide F-like receptor 0.00313991 0.000492846 0.0000560604
Schistosoma mansoni hypothetical protein 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Onchocerca volvulus Tankyrase homolog 0.00466613 0.0154207 0.0162391
Schistosoma mansoni growth hormone secretagogue receptor 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus endoplasmin 0.00455904 0.0143732 0.0143732
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Trypanosoma brucei polo-like protein kinase 0.0133827 0.100677 0.0976826
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni protein kinase 0.00489116 0.0176217 0.0171924
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.00795115 0.0475512 0.04438
Schistosoma mansoni amine GPCR 0.00313991 0.000492846 0.0000560604
Trichomonas vaginalis endoplasmin, putative 0.00454749 0.0142603 0.0109783
Loa Loa (eye worm) AGC/AKT protein kinase 0.0108122 0.0755354 0.0755354
Echinococcus multilocularis tyrosine protein kinase Src42A 0.00761618 0.0442749 0.0442749
Echinococcus granulosus rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus peptide allatostatin:somatostatin 0.00313991 0.000492846 0.000492846
Schistosoma mansoni biogenic amine receptor 0.00313991 0.000492846 0.0000560604
Schistosoma mansoni serine/threonine protein kinase 0.00330469 0.00210454 0.00166846
Loa Loa (eye worm) G-protein coupled receptor 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00501151 0.0187988 0.0187988
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.00593846 0.0278653 0.0246285
Schistosoma mansoni amine GPCR 0.00313991 0.000492846 0.0000560604
Schistosoma mansoni alpha-1 adrenergic receptor 0.00313991 0.000492846 0.0000560604
Schistosoma mansoni hypothetical protein 0.00313991 0.000492846 0.0000560604
Trypanosoma brucei rac serine-threonine kinase, putative 0.0108122 0.0755354 0.0724574
Entamoeba histolytica protein kinase, putative 0.00481023 0.0168302 0.0135566
Echinococcus granulosus poly (ADP ribose) polymerase 0.00977245 0.0653653 0.0653653
Echinococcus granulosus serotonin receptor 0.00313991 0.000492846 0.000492846
Brugia malayi Immunoglobulin I-set domain containing protein 0.0187853 0.153519 0.153102
Entamoeba histolytica protein kinase , putative 0.105329 1 1
Loa Loa (eye worm) norepinephrine transporter 0.0295223 0.258537 0.258537
Schistosoma mansoni serine/threonine protein kinase 0.00555585 0.0241229 0.0236965
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Entamoeba histolytica SH2-protein kinase domain containing protein 0.00524231 0.0210562 0.0177968
Mycobacterium tuberculosis Hypothetical protein 0.00811611 0.0491647 0.274578
Entamoeba histolytica cell division protein kinase 2, putative 0.076444 0.717475 0.716534
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.100802 0.955722 0.955574
Brugia malayi Protein kinase domain containing protein 0.030928 0.272286 0.271927
Loa Loa (eye worm) TYRA-2 protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0133827 0.100677 0.100677
Echinococcus granulosus nervana 2 0.00488937 0.0176042 0.0176042
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00501151 0.0187988 0.01837
Trichomonas vaginalis CAMK family protein kinase 0.0133827 0.100677 0.0976826
Trypanosoma brucei heat shock protein 90, putative 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Onchocerca volvulus 0.097124 0.919744 1
Echinococcus multilocularis calcium activated potassium channel 0.00343377 0.00336708 0.00336708
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.00847933 0.0527173 0.0527173
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0133827 0.100677 0.100677
Echinococcus multilocularis tyrosine protein kinase ABL1 0.00400992 0.00900238 0.00900238
Echinococcus granulosus tyrosine protein kinase shark 0.0474233 0.433625 0.433625
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.00555585 0.0241229 0.0241229
Echinococcus multilocularis protein tyrosine kinase 0.0305588 0.268675 0.268675
Echinococcus granulosus activin receptor type 0.00489116 0.0176217 0.0176217
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0299037 0.262268 0.261945
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Trypanosoma brucei protein kinase, putative 0.00489116 0.0176217 0.0143508
Trichomonas vaginalis CMGC family protein kinase 0.100802 0.955722 0.955574
Brugia malayi cell division control protein 2 homolog 0.076444 0.717475 0.717336
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Plasmodium vivax amine transporter, putative 0.00501151 0.0187988 0.0155319
Echinococcus granulosus tachykinin peptides receptor 99D 0.00313991 0.000492846 0.000492846
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0237568 0.202145 0.199489
Trypanosoma cruzi rac serine-threonine kinase, putative 0.00795115 0.0475512 0.04438
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.00795115 0.0475512 0.0475512
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Brugia malayi Variant SH3 domain containing protein 0.00339001 0.00293902 0.00244738
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0555961 0.513563 0.511944
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0115638 0.0828867 0.0828867
Echinococcus granulosus sodium and chloride dependent glycine 0.00501151 0.0187988 0.0187988
Echinococcus granulosus poly ADP ribose polymerase 1 0.0555961 0.513563 0.513563
Echinococcus granulosus neuropeptides capa receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni neuropeptide f receptor 76f 0.00313991 0.000492846 0.0000560604
Trypanosoma cruzi polo-like protein kinase, putative 0.0133827 0.100677 0.0976826
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.00555585 0.0241229 0.0241229
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00313991 0.000492846 0.000492846
Entamoeba histolytica protein kinase, putative 0.00555585 0.0241229 0.0208737
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0096002 0.0636805 0.0636805
Loa Loa (eye worm) IKK protein kinase 0.097124 0.919744 0.919744
Schistosoma mansoni neuropeptide receptor 0.0338732 0.301093 0.300788
Echinococcus multilocularis fmrfamide receptor 0.00313991 0.000492846 0.000492846
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.100802 0.955722 0.955574
Toxoplasma gondii heat shock protein 90, putative 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis cyclin dependent kinase 5 0.076444 0.717475 0.717475
Onchocerca volvulus 0.0295223 0.258537 0.280712
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.00795115 0.0475512 0.0475512
Echinococcus granulosus rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0158884 0.125185 0.122272
Entamoeba histolytica PH domain containing protein kinase, putative 0.00831818 0.0511411 0.0479818
Echinococcus multilocularis aurora kinase A 0.105329 1 1
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0109512 0.0768946 0.073821
Echinococcus granulosus 7tm_1 domain containing protein 0.00313991 0.000492846 0.000492846
Plasmodium falciparum amino acid transporter, putative 0.00501151 0.0187988 0.0155319
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Echinococcus granulosus mitogen activated protein kinase 3 0.100802 0.955722 0.955722
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Brugia malayi hypothetical protein 0.00811611 0.0491647 0.0486959
Plasmodium falciparum heat shock protein 90 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Trypanosoma cruzi C-8 sterol isomerase, putative 0.040085 0.36185 0.359725
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0138335 0.105086 0.105086
Trichomonas vaginalis conserved hypothetical protein 0.00811611 0.0491647 0.0459989
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.076444 0.717475 0.716534
Brugia malayi SH2 domain containing protein 0.00400992 0.00900238 0.00851373
Trichomonas vaginalis CMGC family protein kinase 0.076444 0.717475 0.716534
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.0155319
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.00555585 0.0241229 0.0241229
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0133827 0.100677 0.0976826
Echinococcus multilocularis tyrosine protein kinase Srms 0.00699077 0.0381578 0.0381578
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.00761618 0.0442749 0.0442749
Onchocerca volvulus Netrin receptor homolog 0.00318236 0.000908059 0.000451687
Schistosoma mansoni pyruvate dehydrogenase 0.0119034 0.0862084 0.0858091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Plasmodium falciparum serine/threonine protein kinase, putative 0.105329 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.00313991 0.000492846 0.000492846
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.013999 0.106705 0.106705
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.00400992 0.00900238 0.00900238
Echinococcus granulosus tyrosine protein kinase Blk 0.00699077 0.0381578 0.0381578
Brugia malayi Protein kinase domain containing protein 0.0451593 0.411481 0.411191
Loa Loa (eye worm) hypothetical protein 0.040085 0.36185 0.36185
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Echinococcus granulosus rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00313991 0.000492846 0.000492846
Echinococcus granulosus sex peptide receptor 0.00313991 0.000492846 0.000492846
Leishmania major protein kinase, putative 0.105329 1 1
Schistosoma mansoni endoplasmin 0.00665461 0.0348699 0.0344481
Schistosoma mansoni serine/threonine protein kinase 0.0156658 0.123007 0.122624
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.00498577 0.0185471 0.0185471
Echinococcus granulosus heat shock protein 90 0.00455904 0.0143732 0.0143732
Giardia lamblia Kinase, STE STE20 0.0109512 0.0768946 0.0634331
Echinococcus granulosus thymidylate synthase 0.0170604 0.136648 0.136648
Echinococcus multilocularis protein kinase c iota type 0.00555585 0.0241229 0.0241229
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.00489116 0.0176217 0.0143508
Schistosoma mansoni protein kinase 0.00498577 0.0185471 0.0181182
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) solute carrier family 6 member 4 0.0295223 0.258537 0.258537
Loa Loa (eye worm) melatonin receptor type 1A 0.00313991 0.000492846 0.000492846
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis neuropeptide Y receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni protein kinase 0.0109512 0.0768946 0.0764912
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis AGC family protein kinase 0.105329 1 1
Onchocerca volvulus DNA ligase 3 homolog 0.00593846 0.0278653 0.0297769
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.00455904 0.0143732 0.5
Echinococcus granulosus mitogen activated protein kinase 14 0.0158884 0.125185 0.125185

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
ED50 (functional) = 8600 nM Cytotoxicity against human KB cells after 72 hrs by SRB assay ChEMBL. 9917283
IC50 (functional) = 29 nM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs ChEMBL. 9917283
IC50 (functional) = 105 nM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs ChEMBL. 9917283
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 9917283

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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