Detailed information for compound 100362

Basic information

Technical information
  • TDR Targets ID: 100362
  • Name: 2,2-dimethyl-1-[3-[(4R)-2-pyridin-3-yl-1,3-th iazolidine-4-carbonyl]indol-1-yl]propan-1-one
  • MW: 393.502 | Formula: C22H23N3O2S
  • H donors: 1 H acceptors: 3 LogP: 3.58 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cn(c2c1cccc2)C(=O)C(C)(C)C)[C@@H]1CSC(N1)c1cccnc1
  • InChi: 1S/C22H23N3O2S/c1-22(2,3)21(27)25-12-16(15-8-4-5-9-18(15)25)19(26)17-13-28-20(24-17)14-7-6-10-23-11-14/h4-12,17,20,24H,13H2,1-3H3/t17-,20?/m0/s1
  • InChiKey: SKFFSSPNEHZZSL-DIMJTDRSSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,2-dimethyl-1-[3-[(4R)-2-(3-pyridyl)thiazolidine-4-carbonyl]indol-1-yl]propan-1-one
  • 2,2-dimethyl-1-[3-[oxo-[(4R)-2-(3-pyridyl)-4-thiazolidinyl]methyl]-1-indolyl]-1-propanone
  • 2,2-dimethyl-1-[3-[[(4R)-2-pyridin-3-yl-1,3-thiazolidin-4-yl]carbonyl]indol-1-yl]propan-1-one
  • 2,2-dimethyl-1-[3-[(4R)-2-pyridin-3-yl1,3-thiazolidine-4-carbonyl]indol-1-yl]propan-1-one
  • 2,2-dimethyl-1-[3-[oxo-[(4R)-2-(3-pyridyl)-4-thiazolidinyl]methyl]-1-indolyl]propan-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Platelet activating factor receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus rhodopsin orphan GPCR Platelet activating factor receptor   342 aa 278 aa 16.5 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 342 aa 19.6 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Platelet activating factor receptor   342 aa 340 aa 23.8 %
Onchocerca volvulus Cyclin-dependent kinase 20 homolog Platelet activating factor receptor   342 aa 383 aa 23.8 %
Echinococcus multilocularis allatostatin A receptor Platelet activating factor receptor   342 aa 334 aa 23.4 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 295 aa 21.7 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 300 aa 21.0 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 321 aa 19.6 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 394 aa 20.3 %
Echinococcus granulosus allatostatin A receptor Platelet activating factor receptor   342 aa 334 aa 22.8 %
Echinococcus multilocularis g-protein coupled receptor Platelet activating factor receptor   342 aa 351 aa 22.5 %
Schistosoma mansoni neuropeptide receptor Platelet activating factor receptor   342 aa 292 aa 20.5 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 319 aa 21.6 %
Echinococcus granulosus tachykinin peptides receptor 99D Platelet activating factor receptor   342 aa 314 aa 21.3 %
Echinococcus granulosus neuropeptide receptor Platelet activating factor receptor   342 aa 304 aa 23.4 %
Loa Loa (eye worm) hypothetical protein Platelet activating factor receptor   342 aa 355 aa 22.5 %
Echinococcus granulosus g-protein coupled receptor Platelet activating factor receptor   342 aa 352 aa 22.2 %
Schistosoma mansoni neuropeptide F-like receptor Platelet activating factor receptor   342 aa 325 aa 22.2 %
Schistosoma mansoni opsin-like receptor Platelet activating factor receptor   342 aa 318 aa 21.7 %
Schistosoma mansoni peptide (allatostatin)-like receptor Platelet activating factor receptor   342 aa 344 aa 25.6 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 320 aa 24.7 %
Echinococcus multilocularis neuropeptide receptor Platelet activating factor receptor   342 aa 303 aa 23.1 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Platelet activating factor receptor   342 aa 283 aa 20.5 %
Schistosoma mansoni neuropeptide receptor Platelet activating factor receptor   342 aa 338 aa 24.9 %
Echinococcus multilocularis rhodopsin orphan GPCR Platelet activating factor receptor   342 aa 278 aa 16.5 %
Onchocerca volvulus Platelet activating factor receptor   342 aa 327 aa 21.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0073 0.023 0.2874
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.014 0.1137
Echinococcus multilocularis Smad4 0.0042 0.0109 0.0108
Echinococcus granulosus tar DNA binding protein 0.0205 0.0745 0.0902
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0241 0.0291
Schistosoma mansoni hypothetical protein 0.0266 0.0984 0.1191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0185 0.1507
Brugia malayi glutaminase DH11.1 0.0267 0.0987 0.3053
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0026 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0061
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0421 0.1593 0.8959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0036 0.0356
Brugia malayi Latrophilin receptor protein 2 0.0266 0.0984 0.3042
Brugia malayi MH2 domain containing protein 0.0621 0.2374 0.7344
Schistosoma mansoni glutamate receptor kainate 0.0164 0.0587 0.071
Toxoplasma gondii histone lysine methyltransferase SET1 0.0178 0.0639 0.813
Echinococcus granulosus metabotropic glutamate receptor 5 0.0084 0.0273 0.033
Echinococcus multilocularis glutamate receptor NMDA 0.1044 0.4032 0.4031
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0017 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0079 0.08
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.023 0.2326
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0051
Schistosoma mansoni smad1 5 8 and 0.0042 0.0109 0.0131
Onchocerca volvulus 0.0021 0.0025 0.0637
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0026 0.0205
Echinococcus multilocularis tar DNA binding protein 0.0205 0.0745 0.0745
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0007 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0025 0.0075
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0663 0.2539 0.7856
Loa Loa (eye worm) hypothetical protein 0.0048 0.0132 0.0406
Giardia lamblia Histone acetyltransferase GCN5 0.0082 0.0264 1
Echinococcus multilocularis cysteine protease 0.0016 0.0007 0.0006
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0115 0.0114
Plasmodium falciparum histone acetyltransferase GCN5 0.0082 0.0264 0.3312
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0019
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0124 0.1007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0115
Mycobacterium tuberculosis Conserved hypothetical protein 0.0173 0.062 0.3452
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0007 0.0006
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0164 0.0587 0.0586
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0026 0.0209
Loa Loa (eye worm) acetyltransferase 0.0304 0.1134 0.3508
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0079 0.08
Brugia malayi beta-lactamase family protein 0.0073 0.023 0.071
Brugia malayi MH2 domain containing protein 0.0042 0.0109 0.0334
Schistosoma mansoni glutamate receptor AMPA 0.0164 0.0587 0.071
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0089 0.0293 0.3688
Echinococcus granulosus GPCR family 2 0.0266 0.0984 0.1191
Brugia malayi CXXC zinc finger family protein 0.009 0.0295 0.0911
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0421 0.1593 0.5
Brugia malayi MH1 domain containing protein 0.0023 0.0035 0.0105
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0115 0.4056
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0075
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0026 0.0078
Schistosoma mansoni smad 0.0042 0.0109 0.0131
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0026 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0025 0.0075
Loa Loa (eye worm) TAR-binding protein 0.0205 0.0745 0.2304
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0164 0.0587 0.071
Echinococcus granulosus cathepsin l1 0.0016 0.0007 0.0007
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0061
Schistosoma mansoni cpg binding protein 0.009 0.0295 0.0357
Loa Loa (eye worm) hypothetical protein 0.0266 0.0984 0.3042
Brugia malayi MH2 domain containing protein 0.0042 0.0109 0.0334
Schistosoma mansoni tyrosine kinase 0.0084 0.0273 0.033
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0122 0.0376
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.023 0.1873
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0036 0.0356
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0286 0.1062 0.1286
Toxoplasma gondii ABC1 family protein 0.0073 0.023 0.2874
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0249 0.0917 0.0916
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0025 0.0075
Brugia malayi RNA recognition motif domain containing protein 0.0205 0.0745 0.2304
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0075
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0249 0.0917 0.111
Schistosoma mansoni tar DNA-binding protein 0.0205 0.0745 0.0902
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0286 0.1062 0.1286
Leishmania major DNA polymerase eta, putative 0.0021 0.0026 0.0205
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0041
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.0551 0.4486
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0025 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0071 0.0711
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.003 0.003
Schistosoma mansoni cpg binding protein 0.0095 0.0315 0.0381
Schistosoma mansoni glutamate receptor kainate 0.0164 0.0587 0.071
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0026 0.0025
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0164 0.1332
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0304 0.1134 0.1374
Echinococcus multilocularis importin subunit beta 1 0.0062 0.0186 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0115 0.1156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0071 0.0711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0058 0.0584
Loa Loa (eye worm) hypothetical protein 0.0084 0.0273 0.0843
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0026 0.0205
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0041
Mycobacterium ulcerans glutaminase 0.0267 0.0987 0.6163
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0026 0.0205
Loa Loa (eye worm) hypothetical protein 0.0088 0.0288 0.0891
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0089 0.0293 0.3688
Schistosoma mansoni glutamate receptor kainate 0.0164 0.0587 0.071
Echinococcus multilocularis NMDA receptor 0.0164 0.0587 0.0586
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0025 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0225
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.023 0.023
Echinococcus multilocularis nmda type glutamate receptor 0.1128 0.4362 0.4361
Loa Loa (eye worm) RGC/RGC protein kinase 0.0084 0.0273 0.0843
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0225
Echinococcus multilocularis tyrosine kinase 0.0084 0.0273 0.0272
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0468 0.1777 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0061
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0025 0.003
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0017 0.0051
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0025 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0061
Brugia malayi MH2 domain containing protein 0.0019 0.0017 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.023 0.1869
Echinococcus granulosus glutamate NMDA receptor subunit 0.0164 0.0587 0.071
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0038 0.0158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0185 0.1507
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0025 0.003
Loa Loa (eye worm) hypothetical protein 0.0073 0.023 0.071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0185 0.1507
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0084 0.0273 0.0843
Giardia lamblia GTOR 0.0044 0.0115 0.3729
Echinococcus multilocularis cysteine protease 0.0016 0.0007 0.0006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0025 0.0024
Loa Loa (eye worm) fibroinase 0.0016 0.0007 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.009 0.0902
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0025 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0025 0.0075
Schistosoma mansoni coup transcription factor 0.0021 0.0025 0.003
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0049
Entamoeba histolytica Ran family GTPase 0.0046 0.0122 0.4332
Loa Loa (eye worm) transcription factor SMAD2 0.0621 0.2374 0.7344
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0185 0.1503
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0084 0.0273 0.0843
Schistosoma mansoni DNA polymerase eta 0.0021 0.0026 0.003
Loa Loa (eye worm) cysteine protease 0.0016 0.0007 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0025 0.0075
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.023 0.1246
Loa Loa (eye worm) glutamate receptor 0.0084 0.0273 0.0843
Echinococcus multilocularis receptor type guanylyl cyclase 0.0084 0.0273 0.0272
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0025 0.0637
Loa Loa (eye worm) Smad1 0.0042 0.0109 0.0334
Echinococcus granulosus glutamate receptor 2 0.0084 0.0273 0.033
Loa Loa (eye worm) hypothetical protein 0.0084 0.0273 0.0843
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0025 0.003
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0007 0.0006
Mycobacterium ulcerans beta-lactamase 0.0073 0.023 0.1369
Loa Loa (eye worm) glutaminase 0.0267 0.0987 0.3053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0115 0.1156
Schistosoma mansoni glutaminase 0.0267 0.0987 0.1195
Brugia malayi hypothetical protein 0.0139 0.0486 0.1502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0054 0.0546
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.0551 0.4486
Echinococcus granulosus atrial natriuretic peptide receptor 0.0084 0.0273 0.033
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.023 0.071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0185 0.1507
Plasmodium falciparum importin beta, putative 0.0062 0.0186 0.231
Entamoeba histolytica acetyltransferase, GNAT family 0.0082 0.0264 0.9668
Brugia malayi hypothetical protein 0.0084 0.0273 0.0843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0122 0.0993
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0025 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0355
Echinococcus granulosus histone acetyltransferase KAT2B 0.0296 0.1101 0.1333
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0115 0.0933
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0025 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0185 0.1507
Entamoeba histolytica hypothetical protein 0.0076 0.0241 0.8802
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.023 0.2326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0071 0.0711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0046 0.0456
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0061
Echinococcus multilocularis dna polymerase eta 0.0021 0.0026 0.0025
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0038 0.0152
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0025 0.0637
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0019
Loa Loa (eye worm) hypothetical protein 0.0062 0.0186 0.0574
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0025 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0079 0.08
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0025 0.0075
Echinococcus granulosus histone acetyltransferase KAT2B 0.0089 0.0293 0.0355
Echinococcus granulosus dna polymerase kappa 0.0021 0.0026 0.003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0163 0.1325
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0124 0.1003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0061
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0096 0.032 0.0387
Leishmania major hypothetical protein, conserved 0.0073 0.023 0.1869
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0023 0.0225
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0286 0.1062 0.1286
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0025 0.0024
Trypanosoma brucei unspecified product 0.0021 0.0026 0.0209
Loa Loa (eye worm) glutamate receptor 2 0.0164 0.0587 0.1814
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0025 0.003
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0017 0.0051
Brugia malayi Glutamate receptor 1 precursor 0.0164 0.0587 0.1814
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.003 0.0036
Schistosoma mansoni cpg binding protein 0.0095 0.0315 0.0381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0061
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0025 0.003
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0001 0.0004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0023 0.0225
Leishmania major cathepsin L-like protease 0.0062 0.0185 0.1503
Brugia malayi hypothetical protein 0.0215 0.0784 0.2425
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.003 0.0036
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0355
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0205 0.0745 0.2304
Echinococcus granulosus tumor protein p63 0.033 0.1234 0.1494
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0075
Loa Loa (eye worm) glutamate receptor 1 0.0164 0.0587 0.1814
Schistosoma mansoni metabotropic glutamate receptor 0.0084 0.0273 0.033
Echinococcus granulosus glutamate receptor NMDA 0.1044 0.4032 0.4884
Loa Loa (eye worm) RGC/RGC protein kinase 0.0084 0.0273 0.0843
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.023 0.1246
Brugia malayi Guanylyl cyclase protein 23 0.0084 0.0273 0.0843
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0133 0.1081
Loa Loa (eye worm) hypothetical protein 0.0084 0.0273 0.0843
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0115 0.0353
Schistosoma mansoni hypothetical protein 0.0266 0.0984 0.1191
Schistosoma mansoni glutamate receptor NMDA 0.0164 0.0587 0.071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0075
Toxoplasma gondii LsmAD domain-containing protein 0.0215 0.0784 1
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0115
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0026 0.0255
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0122 0.0376
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0023 0.0225
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0019
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.023 0.1246
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0122 0.1484
Schistosoma mansoni tar DNA-binding protein 0.0205 0.0745 0.0902
Brugia malayi RNA, U transporter 1 0.0177 0.0635 0.1962
Plasmodium vivax importin-beta 2, putative 0.0062 0.0186 0.231
Schistosoma mansoni tar DNA-binding protein 0.0205 0.0745 0.0902
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0249 0.0917 0.0916
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0132 0.0159
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0017 0.002
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0038 0.0115
Echinococcus granulosus dnaJ subfamily B 0.128 0.4955 0.6002
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0026 0.0089
Leishmania major DNA polymerase kappa, putative 0.0021 0.0026 0.0205
Loa Loa (eye worm) hypothetical protein 0.0073 0.023 0.071
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0124 0.1003
Echinococcus multilocularis GPCR, family 2 0.0266 0.0984 0.0983
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0007 0.0007
Mycobacterium tuberculosis Conserved protein 0.0073 0.023 0.1246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0044 0.0446
Echinococcus multilocularis glutamate receptor 2 0.0249 0.0917 0.0916
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0122 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0071 0.0711
Echinococcus granulosus Smad4 0.0042 0.0109 0.0131
Brugia malayi beta-lactamase family protein 0.0073 0.023 0.071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0046 0.0456
Brugia malayi nuclear hormone receptor 0.0021 0.0025 0.0075
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0122 0.1484
Loa Loa (eye worm) latrophilin receptor protein 2 0.0266 0.0984 0.3042
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0071 0.0824
Entamoeba histolytica hypothetical protein 0.0076 0.0241 0.8802
Echinococcus granulosus nmda type glutamate receptor 0.163 0.6326 0.7663
Entamoeba histolytica hypothetical protein 0.0076 0.0241 0.8802
Loa Loa (eye worm) hypothetical protein 0.0215 0.0784 0.2425
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0026 0.0205
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0164 0.0587 0.071
Brugia malayi MH1 domain containing protein 0.0023 0.0035 0.0105
Brugia malayi Glutamate receptor 2 precursor 0.0164 0.0587 0.1814
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0122 0.0989
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0155 0.0551 0.4488
Brugia malayi beta-lactamase 0.0073 0.023 0.071
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0025 0.0075
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.008 0.0644
Echinococcus multilocularis dnaJ subfamily B 0.128 0.4955 0.4955
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0023 0.0225
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0041
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0115
Brugia malayi TAR-binding protein 0.0205 0.0745 0.2304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0025 0.0075
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0025 0.0075
Brugia malayi Receptor family ligand binding region containing protein 0.0084 0.0273 0.0843
Echinococcus granulosus metabotropic glutamate receptor 2 0.0084 0.0273 0.033
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0023 0.0225
Schistosoma mansoni hypothetical protein 0.0663 0.2539 0.3076
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0115 0.0138
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0084 0.0273 0.0272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0061
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0122 0.1484
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0266 0.0984 0.1191
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0328 0.1228 1
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.023 0.2326
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0025 0.003
Loa Loa (eye worm) RGC/RGC protein kinase 0.0084 0.0273 0.0843
Toxoplasma gondii HEAT repeat-containing protein 0.0062 0.0186 0.231
Loa Loa (eye worm) ctsf protein 0.0016 0.0007 0.0019
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.008 0.0644
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.014 0.1416
Echinococcus multilocularis cpg binding protein 0.0095 0.0315 0.0314
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0115 0.4056
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0109 0.0131
Trypanosoma brucei PAB1-binding protein , putative 0.0215 0.0784 0.6385
Echinococcus multilocularis glutamate receptor 2 0.0084 0.0273 0.0272
Brugia malayi RNA binding protein 0.0205 0.0745 0.2304
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0007 0.0049
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0304 0.1134 0.1134
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0026 0.072
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0084 0.0273 0.9241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0046 0.0456
Onchocerca volvulus 0.0024 0.0038 0.1084
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0225
Schistosoma mansoni glutamate receptor NMDA 0.1293 0.5006 0.6063
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0109 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0061
Brugia malayi hypothetical protein 0.0088 0.0288 0.0891
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0025 0.0075
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0084 0.0273 0.0843
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0075
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.084 0.3232 1
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0052 0.0159
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0225
Echinococcus granulosus dna polymerase eta 0.0021 0.0026 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0079 0.08
Echinococcus granulosus cpg binding protein 0.0095 0.0315 0.0381
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0115 0.0929
Schistosoma mansoni Smad4 0.0042 0.0109 0.0131
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0078
Loa Loa (eye worm) CXXC zinc finger family protein 0.009 0.0295 0.0911
Schistosoma mansoni Smad4 0.0019 0.0017 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0061
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0586 0.2237 0.2237
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0049
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0025 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0036 0.0356
Schistosoma mansoni smad1 5 8 and 0.0042 0.0109 0.0131
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0122 0.0147
Schistosoma mansoni smad 0.0019 0.0017 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0115 0.1156
Loa Loa (eye worm) hypothetical protein 0.0574 0.2192 0.678
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0019 0.0017 0.0363
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0025 0.003
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0109 0.0131
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0249 0.0917 0.111
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0026 0.0209
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0001 0.0004
Trichomonas vaginalis helicase, putative 0.002 0.0023 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0026 0.0209
Echinococcus granulosus smad 0.0042 0.0109 0.0131
Schistosoma mansoni Smad4 0.0019 0.0017 0.002
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0025 0.003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0124 0.1003
Mycobacterium leprae Probable lipase LipE 0.0073 0.023 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0109 0.0334
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0084 0.0273 0.0272
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0007 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0038 0.0152
Leishmania major mitochondrial DNA polymerase beta 0.0328 0.1228 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0084 0.0273 0.0272
Leishmania major importin beta-1 subunit, putative 0.005 0.014 0.1137
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0249 0.0917 0.111
Trypanosoma cruzi PAB1-binding protein , putative 0.0215 0.0784 0.6383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0185 0.1507
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0026 0.0209
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0038 0.0303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0025 0.0075
Loa Loa (eye worm) hypothetical protein 0.0084 0.0273 0.0843
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.023 0.1246
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0014 0.0094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0286 0.1062 0.1061
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0061
Loa Loa (eye worm) hypothetical protein 0.0084 0.0273 0.0843
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0025 0.003
Loa Loa (eye worm) hypothetical protein 0.0073 0.023 0.071
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0026 0.0209
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0164 0.0587 0.071
Schistosoma mansoni microtubule-associated protein tau 0.2122 0.8255 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0225
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0191 0.0689 0.0835
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0328 0.1228 1
Echinococcus granulosus importin subunit beta 1 0.0062 0.0186 0.0225
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0038 0.0115
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0164 0.0587 0.0586
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0026 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0061
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.023 0.1246
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0105
Leishmania major hypothetical protein, conserved 0.0215 0.0784 0.6383
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.023 0.2326
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0014 0.0116
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0164 0.0587 0.0586
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0025 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0061
Schistosoma mansoni ran 0.0046 0.0122 0.0147
Echinococcus multilocularis nmda type glutamate receptor 0.163 0.6326 0.6326
Schistosoma mansoni tar DNA-binding protein 0.0205 0.0745 0.0902
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0061
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0025 0.003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0023 0.0225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0286 0.1062 0.1061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0025 0.0024
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0084 0.0273 0.0843
Brugia malayi MH1 domain containing protein 0.0042 0.0109 0.0334
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0025 0.0075
Schistosoma mansoni hypothetical protein 0.0164 0.0587 0.071
Loa Loa (eye worm) hypothetical protein 0.0084 0.0273 0.0843
Loa Loa (eye worm) hypothetical protein 0.0084 0.0273 0.0843
Loa Loa (eye worm) hypothetical protein 0.0088 0.0288 0.0891
Brugia malayi acetyltransferase, GNAT family protein 0.0304 0.1134 0.3508
Schistosoma mansoni tar DNA-binding protein 0.0205 0.0745 0.0902
Echinococcus multilocularis snurportin 1 0.0663 0.2539 0.2539
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0038 0.1173
Schistosoma mansoni hypothetical protein 0.128 0.4955 0.6002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0089 0.0293 0.2968
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0035 0.0355
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0025 0.003
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0038 0.0152
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0096 0.032 0.032
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0026 0.0078
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.008 0.0648
Loa Loa (eye worm) beta-lactamase 0.0073 0.023 0.071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0025 0.0075
Echinococcus granulosus glutamate receptor subunit protein glur 0.0164 0.0587 0.071
Brugia malayi steroid hormone receptor 0.0021 0.0025 0.0075
Loa Loa (eye worm) hypothetical protein 0.0084 0.0273 0.0843
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0025 0.0075
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0038 0.1173
Brugia malayi Importin beta-1 subunit 0.0062 0.0186 0.0574
Echinococcus granulosus microtubule associated protein 2 0.2122 0.8255 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0185 0.1507
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0185 0.1503
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0026 0.0075
Echinococcus granulosus nmda type glutamate receptor 0.1128 0.4362 0.5283
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0186 0.1516
Onchocerca volvulus 0.0073 0.023 0.7752
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0038 0.0152
Toxoplasma gondii hypothetical protein 0.0053 0.015 0.1848
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0075
Trichomonas vaginalis esterase, putative 0.0073 0.023 0.2326
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0328 0.1228 1
Schistosoma mansoni tyrosine kinase 0.0084 0.0273 0.033
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0007 0.0061
Entamoeba histolytica hypothetical protein 0.0076 0.0241 0.8802
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0007 0.0007
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0024 0.0196
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0026 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0038 0.0115
Brugia malayi MH1 domain containing protein 0.0042 0.0109 0.0334
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0164 0.0587 0.0586
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0075
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0038 0.0303
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0026 0.0089
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0025 0.003
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0115 0.0929
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0017 0.002
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0026 0.0255
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0007 0.0019
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0007 0.0049
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0049
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.023 0.1246
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0023 0.0225
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0026 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.023 0.1869
Brugia malayi Metabotropic glutamate receptor precursor. 0.0084 0.0273 0.0843
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0026 0.0209
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0185 0.1507
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0185 0.1503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0079 0.08
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0025 0.003
Echinococcus granulosus receptor type guanylyl cyclase 0.0084 0.0273 0.033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0025 0.003
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0019
Echinococcus multilocularis tumor protein p63 0.033 0.1234 0.1233
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.003 0.0036
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0025 0.0637
Trichomonas vaginalis importin beta-1, putative 0.005 0.014 0.1416
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0026 0.0205
Entamoeba histolytica hypothetical protein 0.0084 0.0273 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0025 0.0075
Echinococcus granulosus snurportin 1 0.0663 0.2539 0.3076
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0115 0.0929
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0026 0.0209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0025 0.0075
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0038 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0071 0.0711
Trypanosoma cruzi extracellular receptor, putative 0.0084 0.0273 0.2219
Loa Loa (eye worm) hypothetical protein 0.084 0.3232 1
Schistosoma mansoni glutamate receptor AMPA 0.0164 0.0587 0.071
Loa Loa (eye worm) nuclear factor I 0.0023 0.0035 0.0105
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.023 0.1369
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0109 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0025 0.0075
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0075
Brugia malayi hypothetical protein 0.0076 0.0241 0.0744
Echinococcus multilocularis glutamate receptor 2 0.0164 0.0587 0.0586
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0266 0.0984 0.0983
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0266 0.0984 0.1191
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0041
Echinococcus multilocularis microtubule associated protein 2 0.2122 0.8255 0.8255
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0019
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0007 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0185 0.1507
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0007 0.0007
Mycobacterium tuberculosis Conserved protein 0.0073 0.023 0.1246
Chlamydia trachomatis glutamine binding protein 0.0421 0.1593 1
Onchocerca volvulus 0.0084 0.0273 0.9241
Onchocerca volvulus 0.009 0.0295 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0014 0.0022
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0421 0.1593 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0036 0.0356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0061
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0025 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0038 0.0152
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.005 0.0154
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0052 0.0062
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0286 0.1062 0.3283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0071 0.0711
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0014 0.0094
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0115 0.0933
Onchocerca volvulus 0.0073 0.023 0.7752
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0225
Schistosoma mansoni hypothetical protein 0.0076 0.0241 0.0291
Schistosoma mansoni hypothetical protein 0.0266 0.0984 0.1191
Echinococcus granulosus glutamate receptor 2 0.0249 0.0917 0.111
Schistosoma mansoni eyes absent homolog 0.0088 0.0288 0.0349
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0115 0.0929
Schistosoma mansoni metabotropic glutamate receptor 0.0084 0.0273 0.033
Onchocerca volvulus 0.0048 0.0132 0.4347
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0017 0.0016
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0026 0.003
Brugia malayi Receptor family ligand binding region containing protein 0.0084 0.0273 0.0843
Onchocerca volvulus 0.0073 0.023 0.7752
Brugia malayi latrophilin 2 splice variant baaae 0.0574 0.2192 0.678
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0249 0.0917 0.0916
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.023 0.0278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0185 0.1507
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0286 0.1062 0.1286
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.023 0.1246
Brugia malayi ecdysteroid receptor 0.0021 0.0025 0.0075
Onchocerca volvulus 0.0084 0.0273 0.9241
Leishmania major extracellular receptor, putative 0.0084 0.0273 0.2219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0061
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0122 0.0989
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0026 0.0209
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0025 0.003
Schistosoma mansoni ATP-binding cassette transporter 0.0164 0.0587 0.071
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0421 0.1593 1
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0421 0.1593 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0025 0.003
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0026 0.0075
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.023 0.0278
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0017 0.0051
Loa Loa (eye worm) hypothetical protein 0.0073 0.023 0.071
Schistosoma mansoni hypothetical protein 0.0096 0.032 0.0387
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0026 0.0209
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0109 0.0131
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.023 0.1369
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0025 0.0075
Schistosoma mansoni hypothetical protein 0.0266 0.0984 0.1191
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0025 0.0024
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0026 0.0205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0025 0.0075
Trypanosoma brucei importin beta-1 subunit, putative 0.0062 0.0186 0.1516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0061
Loa Loa (eye worm) hypothetical protein 0.0073 0.023 0.071
Loa Loa (eye worm) hypothetical protein 0.0084 0.0273 0.0843
Trichomonas vaginalis ran, putative 0.0046 0.0122 0.1231
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0007 0.0006
Mycobacterium ulcerans hypothetical protein 0.0173 0.062 0.3838
Loa Loa (eye worm) glutaminase 2 0.0267 0.0987 0.3053
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0185 0.1503
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.003 0.003
Trypanosoma cruzi PAB1-binding protein , putative 0.0215 0.0784 0.6383
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0026 0.0209
Schistosoma mansoni smad1 5 8 and 0.0042 0.0109 0.0131
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0089 0.0293 0.3688
Mycobacterium ulcerans hypothetical protein 0.0073 0.023 0.1369
Schistosoma mansoni ran 0.0046 0.0122 0.0147
Brugia malayi Smad1 0.0042 0.0109 0.0334
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0266 0.0984 0.3042
Loa Loa (eye worm) pigment dispersing factor receptor c 0.084 0.3232 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0071 0.0711
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0026 0.0209
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0025 0.003
Entamoeba histolytica hypothetical protein 0.005 0.014 0.5016
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0025 0.0075
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0038 0.1173
Mycobacterium tuberculosis Conserved protein 0.0073 0.023 0.1246
Mycobacterium leprae conserved hypothetical protein 0.0073 0.023 1
Leishmania major GTP-binding protein, putative 0.0046 0.0122 0.0989
Loa Loa (eye worm) MH2 domain-containing protein 0.0621 0.2374 0.7344
Trichomonas vaginalis glutaminase, putative 0.0267 0.0987 1
Leishmania major cathepsin L-like protease 0.0062 0.0185 0.1503
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.014 0.1416
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0115 0.0353
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0038 0.0303
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0023 0.0225
Schistosoma mansoni protein kinase 0.0084 0.0273 0.033
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0115 0.0138
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0089 0.0293 0.2968
Loa Loa (eye worm) RNA binding protein 0.0205 0.0745 0.2304
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0286 0.1062 0.1286
Schistosoma mansoni importin beta-1 0.0062 0.0186 0.0225
Brugia malayi nuclear receptor NHR-88 0.0021 0.0025 0.0075
Plasmodium falciparum ataxin-2 like protein, putative 0.0215 0.0784 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0286 0.1062 0.3283
Brugia malayi Calcitonin receptor-like protein seb-1 0.084 0.3232 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0241 0.0241
Mycobacterium ulcerans hypothetical protein 0.0024 0.0038 0.0152
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.023 0.071
Plasmodium falciparum ataxin-2 like protein, putative 0.0215 0.0784 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0007 0.0019
Schistosoma mansoni hypothetical protein 0.0574 0.2192 0.2654
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.023 0.2326
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0185 0.1507
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0249 0.0917 0.111
Echinococcus multilocularis smad 0.0042 0.0109 0.0108
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0241 0.0291
Loa Loa (eye worm) hypothetical protein 0.0073 0.023 0.071
Echinococcus granulosus tyrosine kinase 0.0084 0.0273 0.033
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0266 0.0984 0.0983
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0038 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0225
Brugia malayi metabotropic glutamate receptor type 2 0.0084 0.0273 0.0843
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0038 0.0152
Mycobacterium ulcerans lipase LipD 0.0073 0.023 0.1369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0044 0.0446
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0122 0.4037
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0026 0.0209
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.023 0.0278
Plasmodium vivax ataxin-2 like protein, putative 0.0215 0.0784 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0026 0.0209
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0109 0.0108
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0249 0.0917 0.0916
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0025 0.0024
Leishmania major cathepsin L-like protease 0.0062 0.0185 0.1503
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0025 0.0075

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 15.75 mg kg-1 In vivo antagonist activity against PAF-Induced paw edema in the mouse ChEMBL. 8027984
ED50 (functional) = 15.75 mg kg-1 In vivo antagonist activity against PAF-Induced paw edema in the mouse ChEMBL. 8027984
Ki (functional) = 8.8 nM Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]-C18-PAF as radioligand ChEMBL. 8027984
Ki (functional) = 8.8 nM Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]-C18-PAF as radioligand ChEMBL. 8027984

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.