TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 219.1 | Formula: C6H8N2O2Se
H donors: 0 H acceptors: 1 LogP: -0.4 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)n1ccn(c1=[Se])C
InChi: 1S/C6H8N2O2Se/c1-7-3-4-8(5(7)11)6(9)10-2/h3-4H,1-2H3
InChiKey: MXDNKPDDMCHHOE-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lactoperoxidase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Animal haem peroxidase family protein	lactoperoxidase	629 aa	572 aa	34.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0247	0.0382
Trypanosoma brucei	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0024	0.0153	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0449	0.0755
Brugia malayi	beta-lactamase family protein	0.0036	0.0311	0.057
Echinococcus granulosus	ecdysone induced protein 78C	0.0034	0.0282	0.0402
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.007	0.073	0.1169
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0311	0.0846
Echinococcus granulosus	neuropeptide s receptor	0.0488	0.5886	1
Onchocerca volvulus		0.0048	0.0449	0.7922
Onchocerca volvulus	Peroxidase homolog	0.0048	0.0449	0.7922
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0601	0.5752
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0034	0.0282	0.0516
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0282	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0449	0.0755
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0058	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0449	0.0755
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0438	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0449	0.0755
Brugia malayi	Blistered cuticle protein 3	0.0048	0.0449	0.0823
Entamoeba histolytica	hypothetical protein	0.0024	0.0153	0.2949
Echinococcus granulosus	carbonic anhydrase II	0.018	0.208	0.3481
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0034	0.0282	0.1107
Schistosoma mansoni	hypothetical protein	0.0056	0.0551	0.2439
Trypanosoma brucei	ceramide phosphorylethanolamine synthase	0.0024	0.0153	0.0459
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0311	1
Brugia malayi	Sphingomyelin synthase-related 1	0.0024	0.0153	0.028
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0091	0.098	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0282	0.0446
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0087	0.0132
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.018	0.208	0.3812
Schistosoma mansoni	nuclear receptor	0.0016	0.0059	0.0007
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0034	0.0282	0.0516
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0091	0.098	0.1598
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1296	0.2318
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0084	0.0903	0.1655
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0311	0.0846
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0016	0.0059	0.0021
Plasmodium vivax	sphingomyelin synthase 1, putative	0.0024	0.0153	0.0739
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0153	0.2945
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0059	0.0036
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0016	0.0059	0.0012
Brugia malayi	hypothetical protein	0.0018	0.0083	0.0152
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0311	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0282	0.0516
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0034	0.0282	0.0516
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0091	0.098	0.0937
Onchocerca volvulus		0.0048	0.0449	0.7922
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0068	0.0051
Loa Loa (eye worm)	hypothetical protein	0.004	0.0361	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0782	0.1371
Schistosoma mansoni	nuclear receptor	0.0016	0.0059	0.0007
Brugia malayi	nuclear receptor RXR	0.0018	0.0083	0.0152
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0058	0.0011
Echinococcus granulosus	carbonic anhydrase	0.0084	0.0903	0.1466
Echinococcus multilocularis	survival motor neuron protein 1	0.0274	0.3245	0.3213
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0311	0.0846
Echinococcus multilocularis	neuropeptide receptor A26	0.0488	0.5886	0.5867
Schistosoma mansoni	cpg binding protein	0.003	0.0235	0.0875
Brugia malayi	Animal haem peroxidase family protein	0.0048	0.0449	0.0823
Echinococcus granulosus	peroxidasin	0.0048	0.0449	0.0688
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0058	0.0019
Schistosoma mansoni	hypothetical protein	0.0084	0.0903	0.418
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0247	0.0382
Brugia malayi	ecdysteroid receptor	0.0034	0.0282	0.0516
Schistosoma mansoni	nuclear hormone receptor	0.0016	0.0059	0.0007
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0091	0.098	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0311	0.0265
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0016	0.0059	0.0007
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0059	0.0594	0.1915
Loa Loa (eye worm)	hypothetical protein	0.0091	0.098	0.1736
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0311	0.0265
Entamoeba histolytica	hypothetical protein	0.0024	0.0153	0.2949
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0311	0.0881
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0311	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0034	0.0282	0.0516
Plasmodium falciparum	sphingomyelin synthase 1, putative	0.0024	0.0153	0.0739
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0016	0.0059	0.0021
Schistosoma mansoni	carbonic anhydrase-related	0.0084	0.0903	0.418
Brugia malayi	hypothetical protein	0.0274	0.3245	0.5947
Entamoeba histolytica	hypothetical protein	0.0036	0.0311	1
Loa Loa (eye worm)	DR-78	0.0016	0.0059	0.0036
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0034	0.0282	0.0236
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0034	0.0282	0.0516
Brugia malayi	Bromodomain containing protein	0.0081	0.0859	0.1575
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0235	0.036
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0058	0.0011
Echinococcus granulosus	intermediate filament protein	0.0031	0.0247	0.0342
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0034	0.0282	0.0402
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0087	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0059	0.0036
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0282	0.1107
Onchocerca volvulus		0.0036	0.0311	0.5117
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0087	0.0086
Trypanosoma brucei	inositol phosphorylceramide synthase	0.0024	0.0153	0.0459
Echinococcus granulosus	sphingomyelin synthase protein 1	0.0024	0.0153	0.0181
Loa Loa (eye worm)	hypothetical protein	0.005	0.0484	0.082
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0129	0.1451	0.2659
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.0024	0.0153	0.028
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0091	0.098	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0449	0.0755
Entamoeba histolytica	hypothetical protein	0.0024	0.0153	0.2949
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0016	0.0059	0.0109
Schistosoma mansoni	lamin	0.0031	0.0247	0.0933
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0311	0.1251
Echinococcus multilocularis	lamin	0.0031	0.0247	0.0201
Brugia malayi	nuclear hormone receptor	0.0016	0.0059	0.0109
Echinococcus granulosus	thyroid hormone receptor alpha	0.0016	0.0059	0.0021
Trypanosoma cruzi	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0024	0.0153	0.0459
Schistosoma mansoni	cpg binding protein	0.0034	0.0281	0.1104
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0034	0.0282	0.0516
Loa Loa (eye worm)	animal heme peroxidase	0.0048	0.0449	0.0755
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0058	0.0033
Echinococcus granulosus	carbonic anhydrase	0.0084	0.0903	0.1466
Echinococcus granulosus	peptidase Clp S14 family	0.0059	0.0594	0.0937
Schistosoma mansoni	survival motor neuron protein	0.0056	0.0551	0.2439
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.0083	0.0152
Brugia malayi	Probable ClpP-like protease	0.0091	0.098	0.1796
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0282	0.0516
Onchocerca volvulus	Bile acid receptor homolog	0.0034	0.0282	0.4523
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0059	0.0036
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0091	0.098	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0311	0.05
Schistosoma mansoni	carbonic anhydrase-related	0.0084	0.0903	0.418
Echinococcus granulosus	zinc finger protein	0.0022	0.0137	0.0154
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0311	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0058	0.0019
Schistosoma mansoni	cpg binding protein	0.0034	0.0281	0.1104
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0019	0.0091	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0311	0.05
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0083	0.008
Brugia malayi	Bromodomain containing protein	0.004	0.036	0.066
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0034	0.0282	0.0516
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.018	0.208	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0311	0.05
Onchocerca volvulus		0.0048	0.0449	0.7922
Echinococcus multilocularis	peroxidasin	0.0048	0.0449	0.0404
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0311	0.1242
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0019	0.0091	0.0164
Echinococcus multilocularis	nuclear receptor nhr 48	0.0016	0.0059	0.0012
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0034	0.0282	0.0446
Schistosoma mansoni	hypothetical protein	0.0035	0.0287	0.1132
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0449	0.0755
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1451	0.2605
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0311	0.05
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0024	0.0153	0.2945
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0031	0.0246	0.1787
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0311	0.1242
Schistosoma mansoni	hypothetical protein	0.0095	0.103	0.4806
Brugia malayi	Nuclear hormone receptor-like 1	0.0034	0.0282	0.0516
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0016	0.0059	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0449	0.0755
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0311	0.251
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0018	0.0083	0.0124
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0091	0.098	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0034	0.0282	0.0446
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0016	0.0059	0.0036
Echinococcus multilocularis	lamin dm0	0.0031	0.0247	0.0201
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0031	0.0246	0.1787
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0016	0.0059	0.0036
Loa Loa (eye worm)	carbonic anhydrase 3	0.018	0.208	0.3766
Entamoeba histolytica	hypothetical protein	0.0036	0.0311	1
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.018	0.208	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0311	0.125
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0034	0.0282	0.0516
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0068	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0059	0.0036
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0247	0.0382
Trichomonas vaginalis	esterase, putative	0.0036	0.0311	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0087	0.5
Brugia malayi	nuclear receptor NHR-67	0.0016	0.0059	0.0109
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0083	0.0124
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0311	0.0846
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0311	0.0846
Loa Loa (eye worm)	nuclear hormone receptor	0.0016	0.0059	0.0036
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.018	0.208	0.3812
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0153	0.0208
Onchocerca volvulus		0.0056	0.0551	1
Brugia malayi	steroid hormone receptor	0.0034	0.0282	0.0516
Onchocerca volvulus		0.0036	0.0311	0.5117
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0176	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0903	0.1594
Schistosoma mansoni	aldehyde dehydrogenase	0.007	0.073	0.3323
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0311	1
Echinococcus multilocularis	neuropeptide s receptor	0.0488	0.5886	0.5867
Schistosoma mansoni	coup transcription factor	0.0034	0.0282	0.1107
Toxoplasma gondii	ABC1 family protein	0.0036	0.0311	0.251
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0059	0.0036
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0176	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0282	0.0446
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0311	0.251
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0019	0.0091	0.0164
Echinococcus granulosus	lamin dm0	0.0031	0.0247	0.0342
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0018	0.0083	0.008
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0311	0.251
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0311	0.1242
Echinococcus multilocularis	zinc finger protein	0.0022	0.0137	0.0091
Brugia malayi	tailless protein	0.0016	0.0059	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0274	0.3245	0.5918
Brugia malayi	conserved hypotetical protein	0.0016	0.0059	0.0109
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.073	0.7199
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0311	0.0846
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0329	0.0483
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0311	0.0451
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0091	0.098	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0058	0.0106
Schistosoma mansoni	peroxidasin	0.0048	0.0449	0.1933
Schistosoma mansoni	lamin	0.0031	0.0247	0.0933
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0311	0.05
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0311	0.057
Brugia malayi	hypothetical protein	0.0036	0.0311	0.0569
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0034	0.0282	0.1107
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.0083	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0449	0.0755
Echinococcus multilocularis	FTZ F1 alpha	0.0129	0.1451	0.141
Echinococcus multilocularis	sphingomyelin synthase protein 1	0.0024	0.0153	0.0106
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0233	0.2737	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.073	0.7199
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0083	0.008
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0282	0.0446
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0311	0.0452
Schistosoma mansoni	retinoic acid receptor RXR	0.0034	0.0282	0.1107
Brugia malayi	MH2 domain containing protein	0.0116	0.1296	0.2375
Onchocerca volvulus	Peroxidase homolog	0.0048	0.0449	0.7922
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0311	0.0881
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0311	0.0846
Brugia malayi	PHD-finger family protein	0.0028	0.0207	0.0379
Schistosoma mansoni	thyroid hormone receptor	0.0034	0.0282	0.1107
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0034	0.0282	0.0402
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.018	0.208	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0449	0.0755
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0311	0.251
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0087	0.0132
Onchocerca volvulus		0.003	0.0235	0.3572
Schistosoma mansoni	bromodomain containing protein	0.0068	0.0707	0.3208
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0065	0.066	0.0616
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0282	0.0402
Brugia malayi	CXXC zinc finger family protein	0.003	0.0235	0.0431
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0087	0.004
Brugia malayi	nuclear receptor NHR-88	0.0034	0.0282	0.0516
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0311	0.125
Entamoeba histolytica	hypothetical protein	0.0036	0.0311	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0449	0.0755
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0311	0.0846
Brugia malayi	Nuclear hormone receptor E75	0.0016	0.0059	0.0109
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.007	0.073	0.2426
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0058	0.0011
Schistosoma mansoni	hypothetical protein	0.0022	0.013	0.0354
Brugia malayi	hypothetical protein	0.0016	0.0059	0.0109
Schistosoma mansoni	nuclear hormone receptor	0.0034	0.0282	0.1107
Entamoeba histolytica	hypothetical protein	0.0024	0.0153	0.2949
Echinococcus granulosus	FTZ F1 alpha	0.048	0.5786	0.9828
Brugia malayi	hypothetical protein	0.0018	0.0083	0.0152
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0034	0.0282	0.0446
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0056	0.0551	0.101
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0129	0.1451	0.2404
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0059	0.0594	0.055
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0287	0.0456
Onchocerca volvulus		0.0031	0.0247	0.3811
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0016	0.0059	0.0021
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0091	0.098	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0059	0.0036
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0016	0.0059	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0903	0.1594
Toxoplasma gondii	aldehyde dehydrogenase	0.007	0.073	0.7199
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0287	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0083	0.008
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0311	0.05
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0016	0.0059	0.0012
Echinococcus multilocularis	ecdysone induced protein 78C	0.0034	0.0282	0.0236
Onchocerca volvulus	Peroxidasin homolog	0.0048	0.0449	0.7922
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0311	0.05
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0311	0.05
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0016	0.0059	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0392	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0282	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0059	0.0036
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0016	0.0059	0.0007
Schistosoma mansoni	nuclear hormone receptor	0.0016	0.0059	0.0007
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0058	0.0033
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 2	0.0024	0.0153	0.028
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0034	0.0282	0.0402
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.018	0.208	1
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.0453	0.5456	1
Brugia malayi	nuclear receptor NHR-88	0.0016	0.0059	0.0109
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0087	0.0132
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0087	0.0132
Brugia malayi	Nuclear hormone receptor E75	0.0016	0.0059	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0059	0.0036
Brugia malayi	nuclear hormone receptor	0.0034	0.0282	0.0516
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0034	0.0282	0.0446
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0129	0.1451	0.2659
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0311	0.0846
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0059	0.0594	0.1915
Toxoplasma gondii	hypothetical protein	0.0084	0.0903	0.914
Leishmania major	phosphatidylcholine:ceramide cholinephosphotransferase 2	0.0024	0.0153	0.0459
Loa Loa (eye worm)	steroid hormone receptor	0.0034	0.0282	0.0446
Schistosoma mansoni	carbonic anhydrase	0.0084	0.0903	0.418
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.013	0.0166
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0282	0.0236
Schistosoma mansoni	zinc finger protein	0.0016	0.006	0.001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0083	0.008
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0091	0.098	1
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.0083	0.0062
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 2	0.0024	0.0153	0.028
Echinococcus granulosus	carbonic anhydrase	0.0084	0.0903	0.1466
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0084	0.0903	0.1655
Schistosoma mansoni	peptidase Clp (S14 family)	0.0091	0.098	0.456
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0034	0.0282	0.0236
Leishmania major	carbonic anhydrase-like protein	0.018	0.208	1
Echinococcus granulosus	neuropeptide receptor A26	0.0488	0.5886	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0016	0.0059	0.0007
Brugia malayi	Steroid receptor seven-up type 2	0.0034	0.0282	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0449	0.0755
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0034	0.0282	0.0446
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0034	0.0282	0.4523
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0084	0.0903	0.1655
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0034	0.0282	0.0516
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 3	0.0024	0.0153	0.028
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0083	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0282	0.0446
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0034	0.0282	0.1107
Echinococcus granulosus	lamin	0.0031	0.0247	0.0342
Brugia malayi	ecdysone receptor	0.0016	0.0059	0.0109
Schistosoma mansoni	spingomyelin synthetase-related	0.0024	0.0153	0.0469
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0016	0.0059	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0449	0.0755
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0034	0.0282	0.1107
Leishmania major	hypothetical protein, conserved	0.0036	0.0311	0.1242
Plasmodium falciparum	carbonic anhydrase	0.0084	0.0903	0.914
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0018	0.0083	0.0124
Schistosoma mansoni	peroxidasin	0.0048	0.0449	0.1933
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0129	0.1451	0.141
Brugia malayi	Animal haem peroxidase family protein	0.0048	0.0449	0.0823
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0034	0.0282	0.0236
Schistosoma mansoni	ap endonuclease	0.0018	0.0087	0.0142
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0034	0.0282	0.0446
Echinococcus multilocularis	carbonic anhydrase II	0.018	0.208	0.2042
Toxoplasma gondii	hypothetical protein	0.0024	0.0153	0.0739
Schistosoma mansoni	zinc finger protein	0.0016	0.0059	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0153	0.0208
Brugia malayi	hypothetical protein	0.0048	0.0449	0.0823
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0024	0.0153	0.2945
Brugia malayi	intermediate filament protein	0.0031	0.0247	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0047	0.0013
Entamoeba histolytica	hypothetical protein	0.0024	0.0153	0.2949
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.018	0.208	0.3766
Brugia malayi	orphan nuclear receptor NR2E1	0.0016	0.0059	0.0109
Mycobacterium ulcerans	lipase LipD	0.0036	0.0311	0.251
Brugia malayi	Animal haem peroxidase family protein	0.0048	0.0449	0.0823
Plasmodium vivax	sphingomyelin synthase 2, putative	0.0024	0.0153	0.0739
Brugia malayi	nuclear hormone receptor family member odr-7	0.0016	0.0059	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0083	0.008
Trypanosoma brucei	carbonic anhydrase-like protein	0.018	0.208	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0018	0.0083	0.0036
Loa Loa (eye worm)	bromodomain containing protein	0.0019	0.0091	0.0094
Echinococcus multilocularis	musashi	0.0031	0.0247	0.0201
Echinococcus multilocularis	carbonic anhydrase	0.0084	0.0903	0.086
Trypanosoma cruzi	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0024	0.0153	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0282	0.0446
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0484	0.0887
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0024	0.0153	0.2945
Brugia malayi	beta-lactamase	0.0036	0.0311	0.057
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0153	0.0208
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.073	0.7199
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0484	0.0887
Onchocerca volvulus		0.0034	0.0282	0.4523
Brugia malayi	hypothetical protein	0.0016	0.0059	0.0109
Schistosoma mansoni	zinc finger protein	0.0022	0.0137	0.0392
Loa Loa (eye worm)	animal heme peroxidase	0.0048	0.0449	0.0755
Echinococcus multilocularis	carbonic anhydrase	0.0084	0.0903	0.086
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0031	0.0246	0.1787
Schistosoma mansoni	aldehyde dehydrogenase	0.007	0.073	0.3323
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0903	0.1594
Echinococcus granulosus	nuclear receptor nhr 48	0.0016	0.0059	0.0021
Schistosoma mansoni	RAR-like nuclear receptor	0.0034	0.0282	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0059	0.0036
Echinococcus granulosus	histone lysine methyltransferase setb	0.0019	0.0091	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0153	0.0208
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0091	0.098	0.5
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0176	0.0221
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0024	0.0153	0.2945
Loa Loa (eye worm)	animal heme peroxidase	0.0048	0.0449	0.0755
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0449	0.0755
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0034	0.0282	0.0446
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1296	0.2318
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0084	0.0903	0.1655
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0016	0.0059	0.0012
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0034	0.0282	0.1107
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0218	0.0399
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.007	0.073	0.0686
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0091	0.098	1
Brugia malayi	Animal haem peroxidase family protein	0.0048	0.0449	0.0823
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0282	0.0402
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0087	0.0068
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0059	0.0594	0.4744
Schistosoma mansoni	ap endonuclease	0.0018	0.0087	0.0142
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0034	0.0282	0.0402
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.0655	0.2951
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0153	0.0208
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.0083	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0059	0.0036
Loa Loa (eye worm)	blistered cuticle protein 3	0.0048	0.0449	0.0755
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0484	0.082
Schistosoma mansoni	carbonic anhydrase-related	0.0084	0.0903	0.418
Entamoeba histolytica	hypothetical protein	0.0036	0.0311	1
Echinococcus granulosus	cpg binding protein	0.0034	0.0281	0.0401
Plasmodium falciparum	sphingomyelin synthase 2, putative	0.0024	0.0153	0.0739
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0311	0.1251
Loa Loa (eye worm)	animal heme peroxidase	0.0048	0.0449	0.0755
Onchocerca volvulus	Chorion peroxidase homolog	0.0048	0.0449	0.7922
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0129	0.1451	0.6888
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0059	0.0036
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0091	0.098	1
Onchocerca volvulus	Peroxidasin homolog	0.0048	0.0449	0.7922
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0282	0.0446
Echinococcus multilocularis	carbonic anhydrase	0.0084	0.0903	0.086
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0311	0.0846
Trichomonas vaginalis	hypothetical protein	0.0024	0.0153	0.2945
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0065	0.066	0.105
Onchocerca volvulus	Dual oxidase homolog	0.0048	0.0449	0.7922
Onchocerca volvulus	Protein ultraspiracle homolog	0.0034	0.0282	0.4523
Echinococcus granulosus	GPCR family 2	0.0016	0.0058	0.0019
Onchocerca volvulus		0.0031	0.0247	0.3811
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0247	0.0933
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0218	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0031	0.024	0.0369
Plasmodium falciparum	sphingomyelin synthase 1, putative	0.0024	0.0153	0.0739
Brugia malayi	beta-lactamase family protein	0.0036	0.0311	0.057
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0449	0.0755
Onchocerca volvulus		0.0036	0.0311	0.5117
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0034	0.0282	0.0236
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0018	0.0083	0.0062
Toxoplasma gondii	hypothetical protein	0.0031	0.0246	0.1787
Echinococcus granulosus	survival motor neuron protein 1	0.0274	0.3245	0.5477
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0059	0.0036
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0311	0.251
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0034	0.0282	0.1107
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0084	0.0903	0.1594
Schistosoma mansoni	hypothetical protein	0.0016	0.006	0.001
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0084	0.0903	0.1655
Brugia malayi	Peroxidasin	0.0048	0.0449	0.0823
Brugia malayi	Animal haem peroxidase family protein	0.0048	0.0449	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0453	0.5456	1
Trypanosoma brucei	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0024	0.0153	0.0459
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0329	0.0283
Entamoeba histolytica	hypothetical membrane-spanning protein	0.0024	0.0153	0.2949
Brugia malayi	nuclear receptor RXR	0.0016	0.0059	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0091	0.0095
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0247	0.0452
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0034	0.0282	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0059	0.0036
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.007	0.073	0.3316
Echinococcus multilocularis	cpg binding protein	0.0034	0.0281	0.0235

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 19.7 uM	Inhibition of lactoperoxidase-catalyzed iodination of L-tyrosine assessed as 3,5-diiodo-L-tyrosine formation by HPLC	ChEMBL.	18954039

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL507966

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1007738