Detailed information for compound 1008001

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 541.851 | Formula: C25H27Cl3N2O5
  • H donors: 1 H acceptors: 4 LogP: 4.63 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: [N-]=[N+]=C1C(=O)C=C(C2=C1C(=O)[C@]1([C@](C2=O)(Cl)C[C@H](C(O1)(C)C)Cl)C[C@@H]1C(=C)CC[C@@H](C1(C)C)Cl)O
  • InChi: 1S/C25H27Cl3N2O5/c1-11-6-7-15(26)22(2,3)12(11)9-25-21(34)18-17(13(31)8-14(32)19(18)30-29)20(33)24(25,28)10-16(27)23(4,5)35-25/h8,12,15-16,31H,1,6-7,9-10H2,2-5H3/t12-,15+,16-,24+,25+/m1/s1
  • InChiKey: HYDZZTKLIACTQZ-NLBVGZHFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0051 0.0391
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0061 0.0201 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Onchocerca volvulus 0.008 0.0283 0.1634
Plasmodium falciparum cysteine repeat modular protein 1 0.0119 0.0452 1
Toxoplasma gondii hypothetical protein 0.008 0.0283 0.0588
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0035 0.0984
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Onchocerca volvulus 0.0119 0.0452 0.2824
Echinococcus multilocularis neurogenic locus notch protein 4 0.006 0.0196 0.0194
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0102 0.0099
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.006 0.0197 0.0181
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0153 0.0136
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0256 0.0253
Brugia malayi Calcium binding EGF domain containing protein 0.006 0.0197 0.17
Brugia malayi MAP kinase sur-1 0.0061 0.0201 0.1736
Echinococcus granulosus snurportin 1 0.0351 0.1464 0.1462
Schistosoma mansoni ap endonuclease 0.0022 0.0035 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0151
Brugia malayi PAN domain containing protein 0.008 0.0283 0.2465
Echinococcus granulosus importin subunit beta 1 0.0033 0.008 0.0078
Schistosoma mansoni ran 0.0024 0.0042 0.0026
Schistosoma mansoni cell polarity protein 0.006 0.0196 0.018
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.0235 0.1604
Loa Loa (eye worm) hypothetical protein 0.008 0.0283 0.1933
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0247 0.0244
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0035 0.5
Loa Loa (eye worm) hypothetical protein 0.008 0.0283 0.1933
Brugia malayi Calcitonin receptor-like protein seb-1 0.0217 0.0879 0.7782
Brugia malayi Muscleblind-like protein 0.0178 0.0712 0.6297
Leishmania major hypothetical protein, conserved 0.0119 0.0452 0.5812
Onchocerca volvulus 0.0062 0.0206 0.1094
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0123 0.0121
Echinococcus multilocularis survival motor neuron protein 1 0.0274 0.1127 0.1125
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0256 0.1747
Onchocerca volvulus Neurogenic locus notch homolog 0.006 0.0196 0.1022
Echinococcus multilocularis lamin 0.0031 0.0073 0.007
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0051 0.0391
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0206 0.019
Echinococcus multilocularis snurportin 1 0.0351 0.1464 0.1462
Onchocerca volvulus 0.0062 0.0206 0.1094
Schistosoma mansoni hypothetical protein 0.006 0.0196 0.018
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0201 0.1831
Brugia malayi Calcium binding EGF domain containing protein 0.006 0.0196 0.1689
Toxoplasma gondii PAN/Apple domain-containing protein 0.008 0.0283 0.0588
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0349 0.4434
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0061 0.0201 0.2468
Loa Loa (eye worm) PAN domain-containing protein 0.008 0.0283 0.1933
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0206 0.019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0191 0.0766 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.0201 0.4246
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0026 0.0023
Onchocerca volvulus 0.008 0.0283 0.1634
Brugia malayi Bromodomain containing protein 0.0046 0.0136 0.1149
Brugia malayi EGF-like domain containing protein 0.006 0.0196 0.1689
Toxoplasma gondii subtilisin SUB12 0.008 0.0283 0.0588
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0118 0.0116
Mycobacterium ulcerans aldehyde dehydrogenase 0.0191 0.0766 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0042 0.0018
Echinococcus granulosus tissue type plasminogen activator 0.0119 0.0452 0.045
Schistosoma mansoni slit 0.006 0.0196 0.018
Schistosoma mansoni hypothetical protein 0.0042 0.0118 0.0102
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0022 0.5
Schistosoma mansoni hypothetical protein 0.0069 0.0235 0.0219
Brugia malayi Trypsin family protein 0.0062 0.0206 0.178
Brugia malayi PAN domain containing protein 0.008 0.0283 0.2465
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Echinococcus granulosus mitogen activated protein kinase 3 0.0061 0.0201 0.0199
Brugia malayi hypothetical protein 0.0025 0.0046 0.0344
Onchocerca volvulus 0.006 0.0196 0.1022
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.0511 0.3487
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0201 0.1831
Plasmodium falciparum importin beta, putative 0.0033 0.008 0.1348
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0349 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.0557 0.4914
Echinococcus multilocularis Mastin 0.0106 0.04 0.0397
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0153 0.015
Toxoplasma gondii PAN domain-containing protein 0.0995 0.4261 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0118 0.0116
Loa Loa (eye worm) hypothetical protein 0.0062 0.0206 0.141
Echinococcus multilocularis neurogenic locus notch protein 0.006 0.0196 0.0194
Schistosoma mansoni hypothetical protein 0.006 0.0196 0.018
Schistosoma mansoni hypothetical protein 0.0148 0.0581 0.0565
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0191 0.0766 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0283 0.1933
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0557 0.0555
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0348
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0046 0.0669
Echinococcus granulosus Mastin 0.0106 0.04 0.0397
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0026 0.0023
Echinococcus granulosus neural cadherin 0.006 0.0196 0.0194
Onchocerca volvulus 0.008 0.0283 0.1634
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0042 0.0594
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.008 0.3441
Loa Loa (eye worm) Notch2 0.006 0.0196 0.134
Schistosoma mansoni notch 0.006 0.0196 0.018
Entamoeba histolytica hypothetical protein 0.0042 0.0118 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0035 0.0243
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0051 0.046
Toxoplasma gondii calcium binding egf domain-containing protein 0.006 0.0197 0.0385
Schistosoma mansoni survival motor neuron protein 0.0056 0.018 0.0164
Brugia malayi EGF-like domain containing protein 0.006 0.0196 0.1689
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0206 0.019
Echinococcus multilocularis zinc finger protein 0.0023 0.0039 0.0036
Echinococcus multilocularis neuropeptide receptor A26 0.0468 0.197 0.1968
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0348
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0051 0.0387
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0051 0.1953
Onchocerca volvulus 0.006 0.0196 0.1022
Onchocerca volvulus 0.0031 0.0073 0.0153
Loa Loa (eye worm) hypothetical protein 0.0217 0.0879 0.6
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0035 0.0032
Loa Loa (eye worm) hypothetical protein 0.006 0.0197 0.1348
Loa Loa (eye worm) hypothetical protein 0.006 0.0197 0.1348
Loa Loa (eye worm) hypothetical protein 0.0062 0.0206 0.141
Echinococcus granulosus protein jagged 1 0.006 0.0196 0.0194
Loa Loa (eye worm) hypothetical protein 0.0062 0.0206 0.141
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0061 0.0201 0.1376
Echinococcus multilocularis protein jagged 1 0.006 0.0196 0.0194
Trypanosoma brucei trypanothione reductase 0.0037 0.01 0.45
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0053 0.084
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0042 0.0594
Schistosoma mansoni notch 0.006 0.0196 0.018
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0206 0.019
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0035 0.0032
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.01 0.1098
Toxoplasma gondii calcium binding egf domain-containing protein 0.006 0.0197 0.0385
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.018 0.1542
Brugia malayi Delta serrate ligand family protein 0.006 0.0196 0.1689
Loa Loa (eye worm) hypothetical protein 0.0033 0.008 0.0547
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.0235 0.0233
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Echinococcus granulosus geminin 0.0538 0.2276 0.2274
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0051 0.0387
Giardia lamblia High cysteine protein 0.006 0.0196 0.9686
Brugia malayi latrophilin 2 splice variant baaae 0.0148 0.0581 0.5122
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0051 0.0391
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0053 0.0202
Loa Loa (eye worm) PAN domain-containing protein 0.008 0.0283 0.1933
Brugia malayi PAN domain containing protein 0.008 0.0283 0.2465
Echinococcus multilocularis neuropeptide s receptor 0.0468 0.197 0.1968
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0119 0.0452 1
Toxoplasma gondii PAN domain-containing protein 0.008 0.0283 0.0588
Brugia malayi intermediate filament protein 0.0031 0.0073 0.0586
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0042 0.1399
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0118 0.0102
Echinococcus granulosus notch 0.006 0.0196 0.0194
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0062 0.0206 0.0204
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0256 0.1747
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.01 0.1803
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.006 0.0196 0.018
Leishmania major hypothetical protein, conserved 0.0025 0.0046 0.0389
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0051 0.046
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Brugia malayi RNA binding protein 0.0073 0.0256 0.2221
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.006 0.0197 0.1348
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0206 0.019
Echinococcus multilocularis geminin 0.0538 0.2276 0.2274
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.008 0.0283 0.1933
Loa Loa (eye worm) hypothetical protein 0.0025 0.0046 0.0311
Onchocerca volvulus 0.006 0.0196 0.1022
Echinococcus granulosus intermediate filament protein 0.0031 0.0073 0.007
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.008 0.3441
Onchocerca volvulus 0.0056 0.018 0.0906
Mycobacterium ulcerans hypothetical protein 0.0026 0.0051 0.0387
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0042 0.0289
Loa Loa (eye worm) hypothetical protein 0.008 0.0283 0.1933
Onchocerca volvulus Slit protein homolog 0.006 0.0196 0.1022
Echinococcus multilocularis importin subunit beta 1 0.0033 0.008 0.0078
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0035 0.0418
Onchocerca volvulus 0.0232 0.0946 0.6298
Brugia malayi PAN domain containing protein 0.008 0.0283 0.2465
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0906 0.3874 0.3873
Brugia malayi Pre-SET motif family protein 0.0029 0.0064 0.051
Loa Loa (eye worm) hypothetical protein 0.0062 0.0206 0.141
Brugia malayi PAN domain containing protein 0.008 0.0283 0.2465
Echinococcus multilocularis laminin 0.006 0.0197 0.0195
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.0511 0.3487
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0062 0.0206 0.141
Loa Loa (eye worm) hypothetical protein 0.0274 0.1127 0.7696
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0206 0.019
Loa Loa (eye worm) hypothetical protein 0.008 0.0283 0.1933
Schistosoma mansoni notch 0.006 0.0196 0.018
Plasmodium vivax SET domain protein, putative 0.0029 0.0064 0.0978
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0029 0.0196
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0206 0.0204
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.006 0.0197 0.17
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Schistosoma mansoni microtubule-associated protein tau 0.2314 1 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0062 0.0206 0.178
Echinococcus granulosus slit 2 protein 0.006 0.0196 0.0194
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0151
Giardia lamblia Kinase, CMGC MAPK 0.0061 0.0201 1
Onchocerca volvulus 0.0029 0.0064 0.0093
Schistosoma mansoni notch 0.006 0.0196 0.018
Loa Loa (eye worm) hypothetical protein 0.0049 0.0148 0.1014
Onchocerca volvulus 0.008 0.0283 0.1634
Schistosoma mansoni hypothetical protein 0.0351 0.1464 0.145
Onchocerca volvulus 0.0031 0.0073 0.0153
Brugia malayi Calcium binding EGF domain containing protein 0.006 0.0196 0.1689
Entamoeba histolytica Ran family GTPase 0.0024 0.0042 0.0922
Schistosoma mansoni aldehyde dehydrogenase 0.0191 0.0766 0.0751
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0247 0.0244
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.008 0.0108
Echinococcus multilocularis mitogen activated protein kinase 3 0.0061 0.0201 0.0199
Onchocerca volvulus Neurogenic locus notch protein homolog 0.006 0.0196 0.1022
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0191 0.0766 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0026 0.0009
Schistosoma mansoni ran 0.0024 0.0042 0.0026
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0206 0.019
Echinococcus multilocularis fibrillin 1 0.006 0.0197 0.0195
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0151
Brugia malayi notch-like transmembrane receptor 0.006 0.0196 0.1689
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0061 0.0201 0.0395
Loa Loa (eye worm) PAN domain-containing protein 0.008 0.0283 0.1933
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0053 0.0202
Toxoplasma gondii microneme protein MIC17C 0.008 0.0283 0.0588
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0153 0.015
Echinococcus granulosus neuropeptide s receptor 0.0468 0.197 0.1968
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0069 0.0235 0.0233
Loa Loa (eye worm) hypothetical protein 0.0062 0.0206 0.141
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0051 0.0387
Loa Loa (eye worm) hypothetical protein 0.0051 0.0158 0.1081
Echinococcus granulosus fibropellin Ia 0.006 0.0196 0.0194
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.0201 0.4246
Echinococcus granulosus protein jagged 2 0.006 0.0196 0.0194
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.001 0.0023
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0035 0.5
Leishmania major GTP-binding protein, putative 0.0024 0.0042 0.0345
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0051 0.0447
Brugia malayi Trypsin family protein 0.0062 0.0206 0.178
Brugia malayi hypothetical protein 0.0042 0.0118 0.0991
Brugia malayi Muscle positioning protein 4 0.006 0.0196 0.1689
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0102 0.0099
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0308 0.3881
Entamoeba histolytica hypothetical protein 0.0042 0.0118 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0054 0.0052
Echinococcus multilocularis lamin dm0 0.0031 0.0073 0.007
Toxoplasma gondii microneme protein MIC17B 0.008 0.0283 0.0588
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.0824 0.5624
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0557 0.0555
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0349 0.4434
Schistosoma mansoni hypothetical protein 0.006 0.0196 0.018
Loa Loa (eye worm) hypothetical protein 0.0062 0.0206 0.141
Echinococcus granulosus Tolloid protein 1 0.006 0.0197 0.0195
Loa Loa (eye worm) hypothetical protein 0.0178 0.0712 0.4864
Brugia malayi Trypsin family protein 0.0062 0.0206 0.178
Echinococcus granulosus muscleblind protein 0.0178 0.0712 0.071
Loa Loa (eye worm) hypothetical protein 0.0031 0.0073 0.0496
Brugia malayi Protein kinase domain containing protein 0.0119 0.0452 0.3975
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0061 0.0201 0.2468
Loa Loa (eye worm) hypothetical protein 0.005 0.0153 0.1042
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0046 0.1575
Echinococcus granulosus GPCR family 2 0.0069 0.0235 0.0233
Onchocerca volvulus Putative cubilin 0.006 0.0196 0.1022
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0051 0.046
Brugia malayi Fibulin-1 precursor 0.006 0.0197 0.17
Echinococcus multilocularis neurogenic locus notch protein 0.006 0.0196 0.0194
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0061 0.0201 0.4246
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0046 0.0545
Schistosoma mansoni notch 0.006 0.0196 0.018
Echinococcus multilocularis musashi 0.0031 0.0073 0.007
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0191 0.0766 0.0764
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.001 0.0066
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0123 0.0121
Schistosoma mansoni hypothetical protein 0.0119 0.0452 0.0437
Echinococcus multilocularis notch 0.006 0.0196 0.0194
Loa Loa (eye worm) hypothetical protein 0.006 0.0197 0.1348
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0206 0.019
Toxoplasma gondii hypothetical protein 0.008 0.0283 0.0588
Trichomonas vaginalis ran, putative 0.0024 0.0042 0.0084
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0051 0.0447
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0073 0.0496
Plasmodium falciparum glutathione reductase 0.0037 0.01 0.1803
Loa Loa (eye worm) hypothetical protein 0.008 0.0283 0.1933
Schistosoma mansoni lamin 0.0031 0.0073 0.0056
Echinococcus granulosus delta-like protein 1 0.006 0.0196 0.0194
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0256 0.024
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0206 0.019
Plasmodium vivax importin-beta 2, putative 0.0033 0.008 0.1348
Brugia malayi PAN domain containing protein 0.008 0.0283 0.2465
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0557 0.0555
Schistosoma mansoni hypothetical protein 0.0538 0.2276 0.2263
Schistosoma mansoni intermediate filament proteins 0.0031 0.0073 0.0056
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0059 0.0057
Toxoplasma gondii EGF family domain-containing protein 0.006 0.0196 0.0382
Brugia malayi Importin beta-1 subunit 0.0033 0.008 0.0652
Mycobacterium tuberculosis Probable reductase 0.0085 0.0308 0.3881
Brugia malayi Cadherin domain containing protein 0.006 0.0196 0.1689
Brugia malayi GCC2 and GCC3 family protein 0.006 0.0196 0.1689
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0201 0.1831
Mycobacterium ulcerans hypothetical protein 0.0062 0.0206 0.2477
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0064 0.0048
Toxoplasma gondii microneme protein MIC4 0.008 0.0283 0.0588
Brugia malayi PAN domain containing protein 0.008 0.0283 0.2465
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0042 0.0469
Brugia malayi Pre-SET motif family protein 0.0204 0.0824 0.7291
Echinococcus multilocularis muscleblind protein 1 0.0178 0.0712 0.071
Toxoplasma gondii microneme protein, putative 0.008 0.0283 0.0588
Brugia malayi Trypsin family protein 0.0062 0.0206 0.178
Echinococcus multilocularis muscleblind protein 0.0178 0.0712 0.071
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0035 0.0291
Loa Loa (eye worm) PAN domain-containing protein 0.008 0.0283 0.1933
Echinococcus multilocularis fat cadherin tumor suppressor 0.006 0.0196 0.0194
Brugia malayi Thioredoxin reductase 0.0037 0.01 0.0827
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0256 0.024
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0308 0.3881
Echinococcus multilocularis slit 2 protein 0.006 0.0196 0.0194
Schistosoma mansoni hypothetical protein 0.0056 0.018 0.0164
Echinococcus granulosus enteropeptidase 0.0106 0.04 0.0397
Onchocerca volvulus 0.006 0.0196 0.1022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0557 0.0542
Schistosoma mansoni notch 0.006 0.0196 0.018
Echinococcus granulosus transmembrane protease serine 3 0.0062 0.0206 0.0204
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0042 0.0461
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0201 0.0185
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0046 0.0026
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.01 0.191
Loa Loa (eye worm) hypothetical protein 0.0084 0.0304 0.2076
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0151
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.093
Brugia malayi Latrophilin receptor protein 2 0.0069 0.0235 0.2035
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0042 0.004
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0308 0.3881
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.006 0.0196 0.1689
Onchocerca volvulus 0.008 0.0283 0.1634
Echinococcus multilocularis GPCR, family 2 0.0069 0.0235 0.0233
Onchocerca volvulus 0.0353 0.1472 1
Schistosoma mansoni ap endonuclease 0.0022 0.0035 0.0018
Echinococcus granulosus neurogenic locus notch protein 0.006 0.0196 0.0194
Brugia malayi PHD-finger family protein 0.003 0.0066 0.0529
Echinococcus granulosus neurogenic locus notch protein 4 0.006 0.0196 0.0194
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0062 0.0206 0.0204
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0348
Echinococcus granulosus survival motor neuron protein 1 0.0274 0.1127 0.1125
Echinococcus multilocularis mitogen activated protein kinase 0.0061 0.0201 0.0199
Echinococcus granulosus zinc finger protein 0.0023 0.0039 0.0036
Schistosoma mansoni laminin gamma-3 chain 0.006 0.0196 0.018
Schistosoma mansoni hypothetical protein 0.0538 0.2276 0.2263
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Brugia malayi EGF-like domain containing protein 0.006 0.0196 0.1689
Toxoplasma gondii microneme protein MIC17A 0.008 0.0283 0.0588
Onchocerca volvulus 0.008 0.0283 0.1634
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0256 0.024
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0206 0.019
Brugia malayi EGF-like domain containing protein 0.006 0.0196 0.1689
Onchocerca volvulus 0.0062 0.0206 0.1094
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.01 0.0681
Brugia malayi RNA, U transporter 1 0.0094 0.0344 0.3007
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0064 0.0048
Brugia malayi EGF-like domain containing protein 0.006 0.0196 0.1689
Loa Loa (eye worm) hypothetical protein 0.0031 0.007 0.0479
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0351 0.1464 1
Echinococcus granulosus mitogen activated protein kinase 0.0061 0.0201 0.0199
Onchocerca volvulus 0.008 0.0283 0.1634
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0051 0.0387
Onchocerca volvulus 0.0062 0.0206 0.1094
Echinococcus granulosus lamin 0.0031 0.0073 0.007
Brugia malayi glutathione reductase 0.0037 0.01 0.0827
Schistosoma mansoni hypothetical protein 0.006 0.0196 0.018
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0051 0.0387
Echinococcus granulosus tar DNA binding protein 0.0073 0.0256 0.0253
Echinococcus multilocularis neurogenic locus protein delta 0.006 0.0196 0.0194
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0206 0.019
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0206 0.019
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0106 0.04 0.0384
Entamoeba histolytica hypothetical protein 0.0027 0.0053 0.2206
Toxoplasma gondii kringle domain-containing protein 0.0119 0.0452 0.0988
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0206 0.019
Echinococcus multilocularis protein jagged 2 0.006 0.0196 0.0194
Toxoplasma gondii PAN domain-containing protein 0.008 0.0283 0.0588
Loa Loa (eye worm) RNA binding protein 0.0073 0.0256 0.1747
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0035 0.0229
Echinococcus multilocularis tissue type plasminogen activator 0.0119 0.0452 0.045
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.0235 0.2035
Echinococcus multilocularis neural cadherin 0.006 0.0196 0.0194
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0256 0.024
Echinococcus multilocularis microtubule associated protein 2 0.2314 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Leishmania major trypanothione reductase 0.0037 0.01 0.111
Echinococcus multilocularis fibropellin Ia 0.006 0.0196 0.0194
Onchocerca volvulus 0.006 0.0196 0.1022
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0073 0.0496
Schistosoma mansoni septate junction protein 0.006 0.0196 0.018
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0073 0.0586
Loa Loa (eye worm) hypothetical protein 0.0069 0.0235 0.1604
Schistosoma mansoni hypothetical protein 0.006 0.0196 0.018
Trypanosoma brucei protein kinase, putative 0.0061 0.0201 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0051 0.0387
Echinococcus multilocularis Tolloid protein 1 0.006 0.0197 0.0195
Echinococcus granulosus protein jagged 1 0.006 0.0196 0.0194
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0035 0.0246
Schistosoma mansoni hypothetical protein 0.0025 0.0044 0.0028
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0035 0.0236
Brugia malayi MH2 domain containing protein 0.0132 0.0511 0.4496
Toxoplasma gondii aldehyde dehydrogenase 0.0191 0.0766 0.1731
Schistosoma mansoni hypothetical protein 0.0069 0.0235 0.0219
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Loa Loa (eye worm) bone morphogenetic protein 1b 0.006 0.0197 0.1348
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0044 0.0301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0557 0.0542
Entamoeba histolytica hypothetical protein 0.0042 0.0118 1
Echinococcus granulosus lamin dm0 0.0031 0.0073 0.007
Brugia malayi EGF-like domain containing protein 0.006 0.0196 0.1689
Toxoplasma gondii PAN domain-containing protein 0.0995 0.4261 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0064 0.0062
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.006 0.0197 0.1348
Loa Loa (eye worm) hypothetical protein 0.0148 0.0581 0.3965
Schistosoma mansoni hypothetical protein 0.0069 0.0235 0.0219
Loa Loa (eye worm) PAN domain-containing protein 0.008 0.0283 0.1933
Onchocerca volvulus 0.008 0.0283 0.1634
Brugia malayi EGF-like domain containing protein 0.006 0.0196 0.1689
Echinococcus granulosus glycoprotein Antigen 5 0.0106 0.04 0.0397
Schistosoma mansoni hypothetical protein 0.0069 0.0235 0.0219
Loa Loa (eye worm) hypothetical protein 0.0178 0.0712 0.4864
Schistosoma mansoni hypothetical protein 0.0062 0.0206 0.019
Echinococcus multilocularis enteropeptidase 0.0106 0.04 0.0397
Loa Loa (eye worm) notch protein 0.006 0.0196 0.134
Brugia malayi Bromodomain containing protein 0.009 0.0326 0.285
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0349 0.4434
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0061 0.0201 0.4246
Brugia malayi PAN domain containing protein 0.008 0.0283 0.2465
Echinococcus multilocularis transmembrane protease serine 3 0.0062 0.0206 0.0204
Loa Loa (eye worm) hypothetical protein 0.006 0.0197 0.1348
Loa Loa (eye worm) trypsin family protein 0.0062 0.0206 0.141
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Brugia malayi hypothetical protein 0.0274 0.1127 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0035 0.0168
Echinococcus granulosus neurogenic locus protein delta 0.006 0.0196 0.0194
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0256 0.024
Schistosoma mansoni lamin 0.0031 0.0073 0.0056
Echinococcus multilocularis protein jagged 1 0.006 0.0196 0.0194
Brugia malayi PAN domain containing protein 0.008 0.0283 0.2465
Loa Loa (eye worm) glutathione reductase 0.0037 0.01 0.0681
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0051 0.1953
Onchocerca volvulus 0.008 0.0283 0.1634
Echinococcus granulosus neurogenic locus notch protein 0.006 0.0196 0.0194
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.0557 0.3806
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0151
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0206 0.019
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0217 0.0879 0.6
Schistosoma mansoni zinc finger protein 0.0023 0.0039 0.0022
Loa Loa (eye worm) TK/ROR protein kinase 0.0119 0.0452 0.3088
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0042 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0557 0.0542
Onchocerca volvulus 0.008 0.0283 0.1634
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0557 0.0555
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0256 0.2221
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0022 0.0062
Schistosoma mansoni hypothetical protein 0.0062 0.0206 0.019
Onchocerca volvulus 0.0062 0.0206 0.1094
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Mycobacterium ulcerans aldehyde dehydrogenase 0.0191 0.0766 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0217 0.0879 0.7782
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.0235 0.0233
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0051 0.0387
Entamoeba histolytica hypothetical protein 0.0042 0.0118 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0046 0.0669
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0042 0.0469
Brugia malayi TAR-binding protein 0.0073 0.0256 0.2221
Schistosoma mansoni bromodomain containing protein 0.0076 0.0265 0.0249
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0206 0.019
Onchocerca volvulus Arrow homolog 0.006 0.0197 0.1031
Brugia malayi Trypsin-like protease protein 5 0.0062 0.0206 0.178
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0046 0.0545
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Echinococcus granulosus protein jagged 2 0.006 0.0196 0.0194
Brugia malayi Kringle domain containing protein 0.0119 0.0452 0.3975
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0035 0.0291
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0201 0.1831
Schistosoma mansoni importin beta-1 0.0033 0.008 0.0064
Plasmodium vivax glutathione reductase, putative 0.0037 0.01 0.1803
Trypanosoma cruzi hypothetical protein, conserved 0.0119 0.0452 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0062 0.0206 0.019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0035 0.0418
Toxoplasma gondii PAN domain-containing protein 0.008 0.0283 0.0588
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0308 0.3881
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0026 0.0009
Echinococcus multilocularis neurogenic locus protein delta 0.006 0.0196 0.0194
Loa Loa (eye worm) hypothetical protein 0.0119 0.0452 0.3088
Schistosoma mansoni hypothetical protein 0.006 0.0196 0.018
Echinococcus granulosus neuropeptide receptor A26 0.0468 0.197 0.1968
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0051 0.1953
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0053 0.0202
Onchocerca volvulus 0.0062 0.0206 0.1094
Schistosoma mansoni aldehyde dehydrogenase 0.0191 0.0766 0.0751
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0191 0.0766 0.0764
Brugia malayi hypothetical protein 0.0062 0.0206 0.178
Loa Loa (eye worm) hypothetical protein 0.006 0.0197 0.1348
Toxoplasma gondii PAN domain-containing protein 0.008 0.0283 0.0588
Schistosoma mansoni cercarial elastase (S01 family) 0.0062 0.0206 0.019
Toxoplasma gondii 1,3(4)-beta-glucanase 0.008 0.0283 0.0588
Echinococcus multilocularis glycoprotein Antigen 5 0.0106 0.04 0.0397
Brugia malayi PAN domain containing protein 0.008 0.0283 0.2465
Brugia malayi Cadherin domain containing protein 0.006 0.0196 0.1689
Schistosoma mansoni hypothetical protein 0.006 0.0196 0.018
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0308 0.8613
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Trichomonas vaginalis set domain proteins, putative 0.0232 0.0946 1
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0062 0.0206 0.0204
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0042 0.0315
Echinococcus granulosus laminin 0.006 0.0197 0.0195
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0062 0.0206 0.019
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0064 0.007
Brugia malayi Calcium binding EGF domain containing protein 0.006 0.0196 0.1689
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0308 0.3881
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0153 0.0136
Plasmodium falciparum thioredoxin reductase 0.0037 0.01 0.1803
Onchocerca volvulus 0.008 0.0283 0.1634
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0054 0.0038
Toxoplasma gondii thioredoxin reductase 0.0037 0.01 0.0154
Loa Loa (eye worm) hypothetical protein 0.006 0.0196 0.134
Schistosoma mansoni egf-like domain protein 0.006 0.0197 0.0181
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0069 0.0235 0.0233
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0046 0.0545
Leishmania major importin beta-1 subunit, putative 0.0027 0.0053 0.0488

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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