Detailed information for compound 1024319

Basic information

Technical information
  • TDR Targets ID: 1024319
  • Name: Oprea1_660758
  • MW: 298.355 | Formula: C18H19FN2O
  • H donors: 0 H acceptors: 1 LogP: 2.25 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)CN1C[C@@H]2C[C@H](C1)c1n(C2)c(=O)ccc1
  • InChi: 1S/C18H19FN2O/c19-16-6-4-13(5-7-16)9-20-10-14-8-15(12-20)17-2-1-3-18(22)21(17)11-14/h1-7,14-15H,8-12H2/t14-,15+/m0/s1
  • InChiKey: SAIIUQKGOHHUHH-LSDHHAIUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-4 subunit Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 Get druggable targets OG5_128160 All targets in OG5_128160
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Get druggable targets OG5_128160 All targets in OG5_128160
Onchocerca volvulus Putative nachr subunit Get druggable targets OG5_128160 All targets in OG5_128160
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 Get druggable targets OG5_128160 All targets in OG5_128160
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Get druggable targets OG5_128160 All targets in OG5_128160
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0035 0.0031
Schistosoma mansoni hypothetical protein 0.0362 0.2451 0.4173
Onchocerca volvulus 0.002 0.0024 0.0268
Echinococcus multilocularis lysine specific demethylase 5A 0.0117 0.0712 0.0708
Onchocerca volvulus Huntingtin homolog 0.0126 0.0778 1
Entamoeba histolytica hypothetical protein 0.0074 0.0407 0.8993
Brugia malayi beta-lactamase family protein 0.0041 0.0174 0.0174
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.029 0.1939 0.1936
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.029 0.1939 0.1936
Trichomonas vaginalis hypothetical protein 0.0074 0.0407 0.8995
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0021
Plasmodium vivax JmjC domain containing protein 0.0031 0.0102 0.1834
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0103 0.0103
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.008 0.045 0.0446
Schistosoma mansoni aldehyde dehydrogenase 0.018 0.1161 0.1974
Onchocerca volvulus 0.0028 0.008 0.0985
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0074 0.0407 0.8995
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0103 0.0099
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0159 0.2992
Schistosoma mansoni hypothetical protein 0.0076 0.0418 0.0706
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0074 0.0407 0.0408
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0038 0.0148 0.0246
Echinococcus granulosus geminin 0.0362 0.2451 0.2448
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0021
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0148 0.0144
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0264 0.1755 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0103 0.0099
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0228 0.0225
Echinococcus granulosus GPCR family 2 0.0049 0.0228 0.0225
Echinococcus multilocularis jumonji domain containing 1A 0.0031 0.0102 0.0098
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0171
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0066 0.0983
Toxoplasma gondii hypothetical protein 0.0074 0.0407 0.3302
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0103 0.0103
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.1161 1
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0103 0.0169
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0017 0.0004 0.0004
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0038 0.0148 0.0144
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0174 0.029
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0103 0.0099
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0074 0.0407 0.8994
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0074 0.0407 0.8968
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.0138 0.0134
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0159 0.1102
Loa Loa (eye worm) hypothetical protein 0.0123 0.0755 0.0754
Schistosoma mansoni ap endonuclease 0.008 0.045 0.0761
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.01
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0076 0.0073
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.01
Loa Loa (eye worm) hypothetical protein 0.0051 0.0243 0.024
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0174 0.0171
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0038 0.0148 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0103 0.0103
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0148 0.0144
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0103 0.0169
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0228 0.0225
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.008 0.045 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0174 0.3346
Mycobacterium leprae Probable lipase LipE 0.0041 0.0174 1
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1514 0.1511
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0407 0.8995
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0418 0.0414
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0174 0.017
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0031 0.0102 0.0595
Brugia malayi Cation transporter family protein 0.0038 0.0148 0.0148
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0174 0.3521
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0148 0.0148
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0024 0.002
Onchocerca volvulus 0.0028 0.008 0.0985
Trichomonas vaginalis protein kinase inhibitor, putative 0.0059 0.0303 0.656
Schistosoma mansoni hypothetical protein 0.0362 0.2451 0.4173
Schistosoma mansoni polycystin 1-related 0.002 0.0024 0.0034
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0024 0.002
Echinococcus granulosus neuropeptide receptor A26 0.1424 1 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0123 0.0755 0.0752
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0024 0.0024
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0103 0.0099
Brugia malayi Ets-domain containing protein 0.0079 0.0443 0.0445
Schistosoma mansoni nAChR subunit 0.0038 0.0148 0.0246
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.008 0.045 0.0448
Echinococcus multilocularis muscleblind protein 0.0156 0.0989 0.0986
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0038 0.0148 0.0144
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0228 0.0229
Schistosoma mansoni nAChR subunit 0.0038 0.0148 0.0246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0103 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0103 0.0099
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.01
Echinococcus granulosus intermediate filament protein 0.0028 0.008 0.0076
Schistosoma mansoni jumonji/arid domain-containing protein 0.0122 0.0748 0.1269
Schistosoma mansoni hypothetical protein 0.0022 0.0035 0.0053
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.008 0.045 0.3683
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0103 0.0169
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.029 0.1939 0.1936
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0443 0.044
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0148 0.0148
Schistosoma mansoni nAChR subunit 0.0038 0.0148 0.0246
Brugia malayi hypothetical protein 0.0017 0.0004 0.0004
Treponema pallidum exodeoxyribonuclease (exoA) 0.008 0.045 0.5
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0148 0.0144
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0049 0.0228 0.0225
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0159 0.3177
Brugia malayi Cytochrome P450 family protein 0.01 0.0591 0.0593
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0024 0.002
Brugia malayi exodeoxyribonuclease III family protein 0.008 0.045 0.0451
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.008 0.045 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0174 0.0807
Echinococcus multilocularis neuropeptide s receptor 0.1424 1 1
Brugia malayi Ets-domain containing protein 0.0079 0.0443 0.0445
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0102 0.1617
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0443 0.044
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.008 0.045 0.3683
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.1161 1
Schistosoma mansoni rab6-interacting 0.002 0.0024 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0103 0.01
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0103 0.0099
Loa Loa (eye worm) cytochrome P450 0.0022 0.0035 0.0031
Echinococcus granulosus tumor protein p63 0.0348 0.2355 0.2352
Echinococcus multilocularis lysine specific demethylase 6a 0.0031 0.0102 0.0098
Onchocerca volvulus 0.0041 0.0174 0.2197
Brugia malayi Sphingomyelin synthase-related 1 0.0074 0.0407 0.0408
Brugia malayi jmjC domain containing protein 0.0122 0.0748 0.075
Toxoplasma gondii aldehyde dehydrogenase 0.018 0.1161 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0169 0.1079 0.9275
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.008 0.0076
Brugia malayi jmjC domain containing protein 0.0031 0.0102 0.0102
Onchocerca volvulus 0.0051 0.0243 0.3086
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0123 0.0755 0.0752
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1514 0.1511
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.008 0.045 0.2412
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0038 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0049 0.0228 0.0383
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.002
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.002 0.0024 0.0035
Schistosoma mansoni jumonji/arid domain-containing protein 0.0122 0.0748 0.1269
Brugia malayi beta-lactamase 0.0041 0.0174 0.0174
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0632 0.0634
Entamoeba histolytica exodeoxyribonuclease III, putative 0.008 0.045 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0148 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0103 0.01
Schistosoma mansoni cpg binding protein 0.0094 0.0549 0.0931
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Schistosoma mansoni cytochrome P450 0.0022 0.0035 0.0053
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0066 0.0983
Loa Loa (eye worm) hypothetical protein 0.0126 0.0778 0.0777
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0103 0.0169
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0148 0.0144
Entamoeba histolytica hypothetical protein 0.0076 0.0418 0.9249
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0103 0.0169
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Onchocerca volvulus 0.0038 0.0148 0.1862
Brugia malayi Cytochrome P450 family protein 0.0022 0.0035 0.0035
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0031 0.0102 0.0168
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0174 0.3521
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0121 0.0739 0.0736
Echinococcus granulosus JmjC domain containing protein 4 0.0031 0.0102 0.0098
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0174 0.1232
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0038 0.0148 0.0145
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0038 0.0148 0.0145
Loa Loa (eye worm) hypothetical protein 0.0028 0.008 0.0076
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0174 0.0807
Brugia malayi hypothetical protein 0.0017 0.0004 0.0004
Onchocerca volvulus 0.0038 0.0148 0.1862
Onchocerca volvulus 0.0038 0.0148 0.1862
Brugia malayi jmjC domain containing protein 0.0031 0.0102 0.0102
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0074 0.0407 0.8994
Entamoeba histolytica hypothetical protein 0.0076 0.0418 0.9249
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0103 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0103 0.0103
Schistosoma mansoni lamin 0.0028 0.008 0.013
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0038 0.0148 0.0148
Echinococcus granulosus lysine specific demethylase 5A 0.0122 0.0748 0.0744
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0038 0.0148 0.0148
Brugia malayi Doublecortin family protein 0.002 0.0024 0.0024
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0102 0.0099
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.008 0.045 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.029 0.1939 0.1942
Echinococcus multilocularis phd:f box containing protein 0.0031 0.0102 0.0098
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0174 0.0807
Mycobacterium ulcerans hypothetical protein 0.0041 0.0174 0.1232
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0103 0.0103
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0148 0.0144
Echinococcus multilocularis nAChR subunit 0.0038 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.023 0.1514 0.1516
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0074 0.0407 0.8968
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.008 0.045 0.0446
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0148 0.0144
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0076 0.0072
Brugia malayi hypothetical protein 0.0076 0.0418 0.0419
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0117 0.0712 0.0708
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0148 0.0148
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0076 0.0072
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0148 0.0144
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0148 0.0144
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.008 0.045 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0103 0.0169
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0174 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0031 0.0102 0.0595
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0103 0.0103
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.0138 0.0134
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0159 0.3166
Brugia malayi Fli-1 protein 0.024 0.1589 0.1594
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0159 0.2992
Schistosoma mansoni nAChR subunit 0.0038 0.0148 0.0246
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0123 0.0755 0.0752
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0103 0.0099
Loa Loa (eye worm) hypothetical protein 0.0126 0.0778 0.0777
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0171
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0066 0.0742
Brugia malayi jmjC domain containing protein 0.0031 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0038 0.0148 0.0246
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0103 0.0169
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0035 0.0031
Brugia malayi hypothetical protein 0.002 0.0024 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.029 0.1939 0.33
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0103 0.01
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0103 0.0099
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0159 0.3177
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0174 0.3518
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0024 0.0035
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0103 0.0169
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0021
Loa Loa (eye worm) GABA receptor subunit 0.002 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0156 0.0989 0.0989
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0174 0.3346
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0123 0.0755 0.0754
Schistosoma mansoni intermediate filament proteins 0.0028 0.008 0.013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0174 0.029
Brugia malayi Cation transporter family protein 0.0038 0.0148 0.0148
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0038 0.0034
Schistosoma mansoni hypothetical protein 0.0047 0.0214 0.0358
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0103 0.0103
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0103 0.0099
Brugia malayi intermediate filament protein 0.0028 0.008 0.008
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0148 0.0144
Echinococcus granulosus jumonji domain containing 1A 0.0031 0.0102 0.0098
Echinococcus multilocularis lamin dm0 0.0028 0.008 0.0076
Brugia malayi beta-lactamase family protein 0.0041 0.0174 0.0174
Schistosoma mansoni hypothetical protein 0.0049 0.0228 0.0383
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.008 0.045 1
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0074 0.0407 0.0408
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0148 0.0148
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0159 0.0155
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0148 0.0246
Loa Loa (eye worm) hypothetical protein 0.0106 0.0632 0.063
Schistosoma mansoni hypothetical protein 0.0106 0.0632 0.1071
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0024 0.002
Entamoeba histolytica hypothetical protein 0.0074 0.0407 0.8993
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.029 0.1939 0.33
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0035 0.0031
Onchocerca volvulus 0.0038 0.0148 0.1862
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0117 0.0712 0.0708
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0123 0.0755 0.0752
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0103 0.0169
Plasmodium vivax sphingomyelin synthase 2, putative 0.0074 0.0407 0.8994
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0074 0.0407 0.8995
Entamoeba histolytica hypothetical membrane-spanning protein 0.0074 0.0407 0.8993
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0418 0.0706
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0004 0.0004
Schistosoma mansoni cpg binding protein 0.0089 0.0513 0.0869
Mycobacterium tuberculosis Conserved protein 0.0041 0.0174 0.0807
Onchocerca volvulus 0.0041 0.0174 0.2197
Schistosoma mansoni ets-related 0.024 0.1589 0.2704
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.018 0.1161 1
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0035 0.0031
Onchocerca volvulus 0.002 0.0024 0.0268
Echinococcus granulosus lysine specific demethylase 6a 0.0031 0.0102 0.0098
Echinococcus granulosus dnaJ subfamily C 6 0.0059 0.0303 0.03
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0103 0.0099
Schistosoma mansoni survival motor neuron protein 0.0047 0.0214 0.0358
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Loa Loa (eye worm) CXXC zinc finger family protein 0.0089 0.0513 0.0511
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0243 0.0407
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0148 0.0145
Brugia malayi Cation transporter family protein 0.0038 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0049 0.0228 0.0383
Echinococcus multilocularis neuropeptide receptor A26 0.1424 1 1
Loa Loa (eye worm) DnaJ domain-containing protein 0.0059 0.0303 0.0301
Schistosoma mansoni hypothetical protein 0.0049 0.0228 0.0383
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0066 0.0742
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.002 0.0024 0.0024
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0038 0.0148 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0103 0.0103
Mycobacterium ulcerans lipase LipD 0.0041 0.0174 0.1232
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0102 0.1617
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0103 0.1282
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0031 0.0102 0.1617
Echinococcus multilocularis GPCR, family 2 0.0049 0.0228 0.0225
Entamoeba histolytica hypothetical protein 0.0074 0.0407 0.8993
Schistosoma mansoni neurotransmitter gated ion channel 0.002 0.0024 0.0035
Schistosoma mansoni jumonji domain containing protein 0.0117 0.0712 0.1207
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0038 0.0034
Brugia malayi jmjC domain containing protein 0.0031 0.0102 0.0102
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0148 0.0246
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0103 0.1282
Echinococcus granulosus sphingomyelin synthase protein 1 0.0074 0.0407 0.0403
Echinococcus granulosus dnaJ subfamily B 0.0842 0.5868 0.5866
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0103 0.0169
Schistosoma mansoni hypothetical protein 0.0059 0.0303 0.0511
Brugia malayi jmjC domain containing protein 0.0117 0.0712 0.0714
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0017 0.0004 0.0004
Brugia malayi ecdysteroid receptor 0.0031 0.0103 0.0103
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0074 0.0407 0.0403
Loa Loa (eye worm) hypothetical protein 0.0074 0.0407 0.0405
Brugia malayi hypothetical protein 0.0126 0.0778 0.078
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0074 0.0407 0.8995
Echinococcus multilocularis tumor protein p63 0.0348 0.2355 0.2352
Brugia malayi CXXC zinc finger family protein 0.0089 0.0513 0.0515
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0099
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0024 0.0024
Echinococcus granulosus RUN 0.002 0.0024 0.002
Onchocerca volvulus 0.0089 0.0513 0.6584
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.018 0.1161 0.6549
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0159 0.2992
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0171
Loa Loa (eye worm) hypothetical protein 0.0074 0.0407 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0103 0.0103
Brugia malayi Muscleblind-like protein 0.0156 0.0989 0.0992
Schistosoma mansoni phd/f-box containing protein 0.0031 0.0102 0.0168
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Echinococcus granulosus nAChR subunit 0.002 0.0024 0.0021
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.008 0.045 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.01
Brugia malayi hypothetical protein 0.0017 0.0004 0.0004
Echinococcus multilocularis nAChR subunit 0.002 0.0024 0.0021
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0038 0.0148 0.0148
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.018 0.1161 0.1158
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0228 0.0229
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0038 0.0148 0.0145
Loa Loa (eye worm) hypothetical protein 0.0074 0.0407 0.0405
Echinococcus multilocularis cpg binding protein 0.0094 0.0549 0.0546
Schistosoma mansoni aldehyde dehydrogenase 0.018 0.1161 0.1974
Schistosoma mansoni jumonji domain containing protein 0.0031 0.0102 0.0168
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0074 0.0407 0.8995
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.018 0.1161 0.1158
Loa Loa (eye worm) hypothetical protein 0.0155 0.098 0.098
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.01
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0068 0.0362 0.0359
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0171
Loa Loa (eye worm) beta-lactamase 0.0041 0.0174 0.0171
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0159 0.0265
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0103 0.0099
Onchocerca volvulus 0.0047 0.0214 0.2712
Onchocerca volvulus 0.0038 0.0148 0.1862
Schistosoma mansoni hypothetical protein 0.0842 0.5868 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0021
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0418 0.0414
Loa Loa (eye worm) doublecortin family protein 0.002 0.0024 0.002
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0123 0.0755 0.0752
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0103 0.0169
Onchocerca volvulus 0.0041 0.0174 0.2197
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0066 0.0983
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.008 0.008
Echinococcus granulosus phd:f box containing protein 0.0031 0.0102 0.0098
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0038 0.0148 0.0144
Loa Loa (eye worm) fli-1 protein 0.024 0.1589 0.1591
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0174 0.017
Brugia malayi excitatory GABA receptor EXP-1A 0.0038 0.0148 0.0148
Loa Loa (eye worm) intermediate filament protein 0.0028 0.008 0.0076
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Schistosoma mansoni nAChR subunit 0.0038 0.0148 0.0246
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0102 0.0099
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.01
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0159 0.016
Entamoeba histolytica hypothetical protein 0.0074 0.0407 0.8993
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0148 0.0148
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0038 0.0148 0.0148
Leishmania major hypothetical protein, conserved 0.0026 0.0066 0.0273
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0066 0.0273
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0159 0.0155
Schistosoma mansoni lipoxygenase 0.0084 0.0481 0.0813
Echinococcus multilocularis muscleblind protein 1 0.0156 0.0989 0.0986
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0074 0.0407 0.8968
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0148 0.0144
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0121 0.0739 0.0736
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0159 0.0155
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0074 0.0407 0.8994
Plasmodium vivax sphingomyelin synthase 1, putative 0.0074 0.0407 0.8994
Trichomonas vaginalis esterase, putative 0.0041 0.0174 0.3521
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0171
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0074 0.0407 0.0408
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0099
Schistosoma mansoni coup transcription factor 0.0031 0.0103 0.0169
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0074 0.0407 0.8968
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0159 0.3177
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0103 0.0099
Schistosoma mansoni lipoxygenase 0.0121 0.0739 0.1254
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0024 0.0024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0004 0.0004
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0174 0.3521
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.01
Brugia malayi hypothetical protein 0.0017 0.0004 0.0004
Echinococcus multilocularis lamin 0.0028 0.008 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0103 0.0103
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0103 0.0103
Echinococcus granulosus nAChR subunit 0.0038 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Schistosoma mansoni ap endonuclease 0.008 0.045 0.0761
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0074 0.0407 0.3302
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0148 0.0246
Trichomonas vaginalis ap endonuclease, putative 0.008 0.045 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0174 0.0174
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.1161 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0103 0.0103
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0038 0.0034
Schistosoma mansoni nAChR subunit 0.0038 0.0148 0.0246
Loa Loa (eye worm) cytochrome P450 family protein 0.01 0.0591 0.0589
Onchocerca volvulus 0.0038 0.0148 0.1862
Brugia malayi nuclear hormone receptor 0.0031 0.0103 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0103 0.0103
Trichomonas vaginalis ap endonuclease, putative 0.008 0.045 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0103 0.01
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0159 0.0155
Loa Loa (eye worm) jmjC domain-containing protein 0.0122 0.0748 0.0747
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0103 0.0103
Echinococcus multilocularis geminin 0.0362 0.2451 0.2448
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0074 0.0407 0.0408
Echinococcus multilocularis dnaJ subfamily B 0.0842 0.5868 0.5866
Echinococcus multilocularis RUN 0.002 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.0074 0.0407 0.0405
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0017 0.0004 0.0004
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0174 0.1232
Schistosoma mansoni spingomyelin synthetase-related 0.0074 0.0407 0.0688
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Schistosoma mansoni loxhd1 0.002 0.0024 0.0034
Echinococcus multilocularis 0.0022 0.0035 0.0031
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0066 0.0742
Onchocerca volvulus 0.002 0.0024 0.0261
Loa Loa (eye worm) LGC-31 protein 0.0038 0.0148 0.0145
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0148 0.0144
Entamoeba histolytica hypothetical protein 0.0074 0.0407 0.8993
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0102 0.0099
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0174 0.3521
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0074 0.0407 0.8968
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.029 0.1939 0.33
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0038 0.0148 0.0145
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0103 0.0099
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0038 0.0148 0.0144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0103 0.0099
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.029 0.1939 0.1945
Mycobacterium ulcerans beta-lactamase 0.0041 0.0174 0.1232
Schistosoma mansoni gabp alpha 0.0079 0.0443 0.0749
Echinococcus granulosus lamin 0.0028 0.008 0.0076
Schistosoma mansoni hypothetical protein 0.002 0.0024 0.0034
Entamoeba histolytica hypothetical protein 0.0076 0.0418 0.9249
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Loa Loa (eye worm) hypothetical protein 0.0156 0.0989 0.0989
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0174 0.3346
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0103 0.01
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0159 0.0155
Schistosoma mansoni protein phosphatase 2C 0.0031 0.0102 0.0168
Onchocerca volvulus Putative nachr subunit 0.0123 0.0755 0.971
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0705 0.0704
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.098 0.0983
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0038 0.0034
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0228 0.0225
Loa Loa (eye worm) hypothetical protein 0.0074 0.0407 0.0405
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0148 0.0145
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.098 0.098
Brugia malayi MH2 domain containing protein 0.0116 0.0705 0.0707
Brugia malayi Cytochrome P450 family protein 0.0022 0.0035 0.0035
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0123 0.0755 0.0758
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0038 0.0148 0.0144
Echinococcus multilocularis dnaJ subfamily C 6 0.0059 0.0303 0.03
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0171
Brugia malayi cytochrome P450 0.0022 0.0035 0.0035
Brugia malayi nuclear receptor NHR-88 0.0031 0.0103 0.0103
Echinococcus granulosus cpg binding protein 0.0094 0.0549 0.0546
Brugia malayi Cytochrome P450 family protein 0.0022 0.0035 0.0035
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0038 0.0148 0.0148
Leishmania major hypothetical protein, conserved 0.0041 0.0174 0.1232
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.01
Brugia malayi hypothetical protein 0.0026 0.0066 0.0066
Echinococcus granulosus muscleblind protein 0.0156 0.0989 0.0986
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0103 0.01
Schistosoma mansoni phosphatidylserine receptor 0.0031 0.0102 0.0168
Brugia malayi hypothetical protein 0.002 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0103 0.0103
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0844 0.5882 0.588
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0103 0.0099
Schistosoma mansoni nAChR subunit 0.0038 0.0148 0.0246
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0099
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0159 0.0155
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0443 0.0441
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0123 0.0755 0.0752
Brugia malayi hypothetical protein 0.0017 0.0004 0.0004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0228 0.0225
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0103 0.0099
Echinococcus multilocularis musashi 0.0028 0.008 0.0076
Brugia malayi hypothetical protein 0.023 0.1514 0.1519
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.008 0.045 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.142 0.9969 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.029 0.1939 0.1936
Loa Loa (eye worm) hypothetical protein 0.0028 0.0076 0.0073
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.098 0.0983
Mycobacterium tuberculosis Conserved protein 0.0041 0.0174 0.0807
Plasmodium falciparum JmjC domain-containing protein, putative 0.0031 0.0102 0.1834
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0174 0.0807
Trypanosoma brucei inositol phosphorylceramide synthase 0.0074 0.0407 0.8968
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0103 0.1282
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0174 0.0807
Onchocerca volvulus Huntingtin homolog 0.0126 0.0778 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0031 0.0102 0.0098
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0159 0.0265
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0705 0.0704
Mycobacterium tuberculosis Conserved protein 0.0041 0.0174 0.0807
Toxoplasma gondii exonuclease III APE 0.008 0.045 0.3683
Brugia malayi DnaJ domain containing protein 0.0059 0.0303 0.0304
Schistosoma mansoni lamin 0.0028 0.008 0.013
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.142 0.9969 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0148 0.0148
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0189 0.1223 0.2079
Loa Loa (eye worm) hypothetical protein 0.0039 0.0159 0.0156
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0174 0.3521
Loa Loa (eye worm) hypothetical protein 0.0038 0.0148 0.0145
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0214 0.0214
Onchocerca volvulus 0.002 0.0024 0.0261
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0103 0.0099
Entamoeba histolytica hypothetical protein 0.0076 0.0418 0.9249
Schistosoma mansoni rab6-interacting 0.002 0.0024 0.0034
Onchocerca volvulus 0.0031 0.0103 0.1282
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0174 0.0807
Toxoplasma gondii ABC1 family protein 0.0041 0.0174 0.1232
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0228 0.0225
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0103 0.01
Leishmania major hypothetical protein, conserved 0.0031 0.0102 0.0595
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0174 0.0807
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0103 0.0099
Schistosoma mansoni cpg binding protein 0.0094 0.0549 0.0931
Echinococcus granulosus lamin dm0 0.0028 0.008 0.0076
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0103 0.0169
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0148 0.0144
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0038 0.0058
Brugia malayi steroid hormone receptor 0.0031 0.0103 0.0103

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 183 nM Displacement of [3H]cytisine from alpha4beta2 nicotinic acetylcholine receptor in rat brain cortex membrane homogenates ChEMBL. 19548687
Ki (binding) = 330 nM Displacement of (+/-)-[3H]epibatidine from alpha4beta2 nicotinic acetylcholine receptor in rat brain cortex membrane homogenates ChEMBL. 19548687
Ki (binding) = 78700 nM Displacement of [125I]alpha-bungarotoxin from alpha7 nicotinic acetylcholine receptor in rat brain cortex membrane homogenates ChEMBL. 19548687

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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