Detailed information for compound 1025088

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 292.329 | Formula: C19H16O3
  • H donors: 0 H acceptors: 2 LogP: 3.11 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1=CC(c2ccccc2)C(=O)C(=O)C1c1ccccc1
  • InChi: 1S/C19H16O3/c1-22-16-12-15(13-8-4-2-5-9-13)18(20)19(21)17(16)14-10-6-3-7-11-14/h2-12,15,17H,1H3
  • InChiKey: AXYKUSLHKJFTSV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol kinase 0.0056 0.0183 0.0282
Onchocerca volvulus 0.0109 0.042 0.1938
Echinococcus multilocularis geminin 0.0167 0.0675 0.0671
Schistosoma mansoni hypothetical protein 0.0167 0.0675 0.0941
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.002 0.0277
Schistosoma mansoni transcription factor LCR-F1 0.0052 0.0169 0.0231
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0056 0.0183 0.2336
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0114 0.0441 0.3256
Schistosoma mansoni polycystin 1-related 0.0021 0.0029 0.0036
Echinococcus multilocularis snurportin 1 0.0296 0.1239 0.1235
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0215 0.0296
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0029 0.0064 0.006
Loa Loa (eye worm) hypothetical protein 0.0225 0.0926 0.145
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0089 0.02
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0055 0.0234
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0616 0.265 0.6904
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0012 0.0008
Schistosoma mansoni pyruvate kinase 0.0034 0.0089 0.0119
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0055 0.0234
Mycobacterium ulcerans glutaminase 0.0305 0.1281 1
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0026 0.0383
Echinococcus granulosus GPCR family 2 0.0029 0.0064 0.006
Loa Loa (eye worm) hypothetical protein 0.0301 0.1261 0.1977
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0183 0.0743 0.1916
Loa Loa (eye worm) hypothetical protein 0.0153 0.0611 0.0955
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0183 0.0743 0.1882
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0183 0.0743 0.1036
Echinococcus multilocularis muscleblind protein 1 0.0153 0.0611 0.0607
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.042 0.1032
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.042 0.0416
Echinococcus multilocularis musashi 0.0028 0.006 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0485 0.1204
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0055 0.0234
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0092 0.0344 0.2535
Schistosoma mansoni tar DNA-binding protein 0.013 0.0512 0.0712
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0215 0.0296
Schistosoma mansoni hypothetical protein 0.0029 0.0064 0.0084
Schistosoma mansoni microtubule-associated protein tau 0.0707 0.3048 0.427
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0153 0.0611 0.0955
Echinococcus multilocularis GTP binding nuclear protein Ran 0.002 0.0028 0.0024
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0052 0.0165 0.0401
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0092 0.0344 0.034
Onchocerca volvulus 0.0015 0.0004 0.0019
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.042 0.3145
Loa Loa (eye worm) glutaminase 0.0305 0.1281 0.2007
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0215 0.0211
Schistosoma mansoni hypothetical protein 0.0167 0.0675 0.0941
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0141 0.0561 1
Echinococcus granulosus muscleblind protein 0.0153 0.0611 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Echinococcus multilocularis pyruvate kinase 0.0027 0.0057 0.0053
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0141 0.0561 0.4171
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0316 0.1328 0.3422
Leishmania major hypothetical protein, conserved 0.0109 0.042 0.1117
Brugia malayi TAR-binding protein 0.013 0.0512 0.1329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0134
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0116 0.0232
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.023 0.095 0.5001
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0092 0.0344 0.089
Echinococcus granulosus pyruvate kinase 0.0034 0.0089 0.0085
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0409 0.1737 0.4498
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0141 0.0561 0.0557
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0092 0.0344 0.034
Loa Loa (eye worm) hypothetical protein 0.0024 0.0043 0.0062
Schistosoma mansoni hypothetical protein 0.0296 0.1239 0.1732
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0116 0.0273
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0012 0.0008
Mycobacterium ulcerans beta-lactamase 0.0109 0.042 0.3145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0183 0.0408
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0056 0.0183 0.0448
Brugia malayi jmjC domain containing protein 0.0063 0.0215 0.0554
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1635 0.7132 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0026 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0056 0.0183 0.3213
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0056 0.0183 0.3213
Entamoeba histolytica hypothetical protein 0.0022 0.0037 0.0024
Onchocerca volvulus 0.0064 0.022 0.1013
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0183 0.0408
Leishmania major phosphatidylinositol 3-kinase, putative 0.0183 0.0743 0.2001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0052 0.0169 0.0165
Brugia malayi hypothetical protein 0.0018 0.002 0.0042
Loa Loa (eye worm) hypothetical protein 0.0109 0.042 0.0655
Loa Loa (eye worm) hypothetical protein 0.0026 0.0055 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0251 0.0346
Loa Loa (eye worm) intermediate filament protein 0.0028 0.006 0.0089
Leishmania major hypothetical protein, conserved 0.0018 0.002 0.002
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0141 0.0561 0.1403
Schistosoma mansoni lamin 0.0028 0.006 0.0078
Entamoeba histolytica hypothetical protein 0.0052 0.0169 0.037
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.006 0.0089
Mycobacterium ulcerans hypothetical protein 0.0026 0.0055 0.0234
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0116 0.0273
Brugia malayi jmjC domain containing protein 0.0017 0.0012 0.0023
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0114 0.0441 0.1123
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0183 0.0743 0.1916
Leishmania major importin beta-1 subunit, putative 0.0022 0.0037 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.042 0.107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0183 0.0743 0.0739
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.022 0.0302
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0236 0.0612
Echinococcus multilocularis pyruvate kinase 0.0018 0.0016 0.0011
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.016 0.0641 0.0637
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0183 0.0743 0.0739
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0241 0.056
Schistosoma mansoni tar DNA-binding protein 0.013 0.0512 0.0712
Trypanosoma cruzi importin beta-1 subunit, putative 0.0022 0.0037 0.0065
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0616 0.265 0.6904
Echinococcus multilocularis mucolipin 3 0.0069 0.0241 0.0237
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0533 0.0743
Entamoeba histolytica hypothetical protein 0.0052 0.0169 0.037
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0089 0.0223
Schistosoma mansoni tar DNA-binding protein 0.013 0.0512 0.0712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0029 0.0064 0.0159
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0183 0.0743 0.5554
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Loa Loa (eye worm) pigment dispersing factor receptor c 0.009 0.0336 0.0523
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0069 0.0241 0.0237
Toxoplasma gondii target of rapamycin (TOR), putative 0.0183 0.0743 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.006 0.0056
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0884 0.3826 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0055 0.0134
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0052 0.0165 0.0226
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0012 0.0147
Echinococcus multilocularis ubiquitin specific protease 41 0.0052 0.0165 0.0161
Brugia malayi Pre-SET motif family protein 0.0445 0.1898 0.4956
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0114 0.0441 0.1086
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0442 0.1884 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0441 0.1086
Loa Loa (eye worm) TAR-binding protein 0.013 0.0512 0.0799
Schistosoma mansoni importin beta-1 0.0028 0.006 0.0079
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0445 0.1898 0.2978
Echinococcus granulosus serine protein kinase ATM 0.0114 0.0441 0.0437
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.042 0.1334
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0116 0.0177
Echinococcus granulosus GTP binding nuclear protein Ran 0.002 0.0028 0.0024
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0141 0.0561 0.1403
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0583 0.2503 0.654
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0116 0.0285
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0089 0.0409
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0141 0.0561 0.1403
Brugia malayi Muscleblind-like protein 0.0153 0.0611 0.159
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0056 0.0183 0.0448
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0441 0.1086
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0124 0.0485 0.6474
Onchocerca volvulus 0.0109 0.042 0.1938
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0111 0.0107
Loa Loa (eye worm) hypothetical protein 0.0069 0.0241 0.0373
Brugia malayi beta-lactamase family protein 0.0109 0.042 0.109
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.0037 0.0024
Loa Loa (eye worm) transcription factor SMAD2 0.0185 0.0754 0.118
Schistosoma mansoni pyruvate kinase 0.0034 0.0089 0.0119
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0183 0.0282
Loa Loa (eye worm) hypothetical protein 0.0109 0.042 0.0655
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0183 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0196 0.0442
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0034
Loa Loa (eye worm) hypothetical protein 0.0109 0.042 0.0655
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0055 0.0234
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0183 0.0743 0.5554
Brugia malayi beta-lactamase 0.0109 0.042 0.109
Loa Loa (eye worm) glutaminase 2 0.0305 0.1281 0.2007
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0055 0.0117
Echinococcus multilocularis tar DNA binding protein 0.013 0.0512 0.0508
Brugia malayi Doublecortin family protein 0.0015 0.0004 0.0001
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0089 0.0134
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0043 0.004
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0236 0.0608
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0116 0.0232
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0012 0.0008
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.042 0.1334
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0183 0.0743 0.2001
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.002 0.0019
Echinococcus multilocularis pyruvate kinase 0.0018 0.0016 0.0011
Mycobacterium tuberculosis Conserved hypothetical protein 0.0056 0.0183 0.0542
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.006 0.0365
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0183 0.0743 0.0739
Echinococcus granulosus geminin 0.0167 0.0675 0.0671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0441 0.1086
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.042 0.1334
Loa Loa (eye worm) beta-lactamase 0.0109 0.042 0.0655
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0052 0.0165 0.0361
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0012 0.0011
Leishmania major pyruvate kinase 0.0034 0.0089 0.0209
Loa Loa (eye worm) hypothetical protein 0.0583 0.2503 0.3929
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0316 0.1328 0.3422
Entamoeba histolytica hypothetical protein 0.0114 0.0441 0.1086
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0316 0.1328 0.3422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Schistosoma mansoni hypothetical protein 0.0029 0.0064 0.0084
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0071 0.0251 0.3265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0012 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0183 0.0743 0.1934
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0183 0.0282
Echinococcus multilocularis Zinc finger, PHD finger 0.0141 0.0561 0.0557
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.002 0.0019
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0183 0.0282
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0012 0.0011
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0141 0.0561 0.1438
Schistosoma mansoni tar DNA-binding protein 0.013 0.0512 0.0712
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0012 0.0014
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1357 0.5909 0.5907
Echinococcus granulosus alkaline phosphatase 0.016 0.0641 0.0637
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0296 0.1239 0.1942
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0183 0.3213
Schistosoma mansoni lamin 0.0028 0.006 0.0078
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0034
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0052 0.0165 0.0161
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0034
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0056 0.0183 0.2336
Brugia malayi FAT domain containing protein 0.0069 0.0241 0.062
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0215 0.0211
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0183 0.0743 0.5554
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0012 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0215 0.0333
Plasmodium vivax importin-beta 2, putative 0.0028 0.006 0.1009
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0236 0.0586
Brugia malayi intermediate filament protein 0.0028 0.006 0.0148
Schistosoma mansoni hypothetical protein 0.0056 0.0183 0.0251
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0071 0.0251 0.0653
Loa Loa (eye worm) MH2 domain-containing protein 0.0185 0.0754 0.118
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0183 0.0469
Brugia malayi hypothetical protein 0.0015 0.0004 0.0001
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0316 0.1328 0.3449
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0055 0.0234
Echinococcus granulosus mitogen activated protein kinase 3 0.0071 0.0251 0.0247
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0114 0.0441 0.0612
Echinococcus granulosus pyruvate kinase 0.0018 0.0016 0.0011
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0183 0.0743 0.0739
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0052 0.0165 0.0161
Plasmodium falciparum pyruvate kinase 0.0034 0.0089 0.1519
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0181 0.0249
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0012 0.0011
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0056 0.0183 0.3213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0196 0.0442
Echinococcus granulosus pyruvate kinase 0.0018 0.0016 0.0011
Echinococcus multilocularis alkaline phosphatase 0.016 0.0641 0.0637
Loa Loa (eye worm) hypothetical protein 0.0052 0.0165 0.0254
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0141 0.0561 0.1403
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0089 0.016
Echinococcus multilocularis survival motor neuron protein 1 0.0225 0.0926 0.0922
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.002 0.0028 0.0216
Onchocerca volvulus Huntingtin homolog 0.0137 0.054 0.249
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1635 0.7132 0.7131
Loa Loa (eye worm) hypothetical protein 0.009 0.0336 0.0523
Toxoplasma gondii ABC1 family protein 0.0109 0.042 0.5584
Echinococcus granulosus pyruvate kinase 0.0018 0.0016 0.0011
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0141 0.0561 0.7509
Loa Loa (eye worm) phosphatidylinositol 3 0.0056 0.0183 0.0282
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0055 0.0134
Loa Loa (eye worm) hypothetical protein 0.0109 0.042 0.0655
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0071 0.0251 0.0625
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.022 0.0302
Giardia lamblia Hypothetical protein 0.0056 0.0183 0.0896
Loa Loa (eye worm) hypothetical protein 0.0109 0.042 0.0655
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0052 0.0165 0.0226
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0236 0.0325
Onchocerca volvulus Huntingtin homolog 0.0137 0.054 0.249
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.0251 0.0586
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0116 0.0319
Brugia malayi MAP kinase sur-1 0.0071 0.0251 0.0647
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0052 0.0165 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0441 0.1086
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0116 0.054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Entamoeba histolytica hypothetical protein 0.0056 0.0183 0.0408
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0236 0.17
Schistosoma mansoni intermediate filament proteins 0.0028 0.006 0.0078
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0026 0.0383
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.009 0.0336 0.087
Brugia malayi jmjC domain containing protein 0.0017 0.0012 0.0023
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0141 0.0561 0.0876
Toxoplasma gondii exonuclease III APE 0.004 0.0116 0.1424
Brugia malayi RNA recognition motif domain containing protein 0.013 0.0512 0.1329
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0124 0.0485 0.3596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.0037 0.0024
Brugia malayi MH2 domain containing protein 0.0185 0.0754 0.1964
Brugia malayi RNA binding protein 0.013 0.0512 0.1329
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0052 0.0169 0.0165
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0092 0.0344 0.0476
Trypanosoma cruzi target of rapamycin kinase 3 0.0183 0.0743 0.1916
Onchocerca volvulus 0.0026 0.0055 0.0253
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0089 0.0134
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0884 0.3826 1
Leishmania major GTP-binding protein, putative 0.002 0.0028 0.0043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0055 0.0114
Brugia malayi Coelomocyte uptake defective protein 5 0.0069 0.0241 0.0621
Trypanosoma brucei protein kinase, putative 0.0071 0.0251 0.1813
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0533 0.053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Schistosoma mansoni mucolipin 0.0063 0.0216 0.0297
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0141 0.0561 0.1503
Brugia malayi latrophilin 2 splice variant baaae 0.0062 0.021 0.0541
Schistosoma mansoni fkbp-rapamycin associated protein 0.0114 0.0441 0.0612
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0056 0.0183 0.0469
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0052 0.0165 0.0361
Loa Loa (eye worm) phosphatidylinositol 3 0.0183 0.0743 0.1162
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.022 0.0216
Onchocerca volvulus 0.0055 0.0181 0.0836
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0055 0.007
Entamoeba histolytica hypothetical protein 0.0709 0.3059 0.7981
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.042 0.1032
Toxoplasma gondii LsmAD domain-containing protein 0.0018 0.002 0.0099
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0141 0.0561 0.1438
Leishmania major pyruvate kinase 0.0034 0.0089 0.0209
Plasmodium vivax hypothetical protein 0.0056 0.0183 0.3213
Loa Loa (eye worm) mucolipin 1 0.0069 0.0241 0.0373
Leishmania major hypothetical protein, conserved 0.0847 0.3663 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.054 0.0843
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0029 0.0064 0.006
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.016 0.0641 0.0637
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0055 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0069 0.0241 0.0237
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0052 0.0165 0.0161
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.0533 0.0833
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0116 0.0232
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0215 0.0296
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0709 0.3059 0.7981
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.002 0.0028 0.0067
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0055 0.0234
Loa Loa (eye worm) hypothetical protein 0.0114 0.0441 0.0687
Entamoeba histolytica hypothetical protein 0.0052 0.0169 0.037
Echinococcus multilocularis mitogen activated protein kinase 0.0071 0.0251 0.0247
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.2287 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0441 0.1086
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.042 0.109
Echinococcus multilocularis GPCR, family 2 0.0029 0.0064 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0014
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0071 0.0251 0.1813
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0012 0.0008
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0056 0.0183 0.0179
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0089 0.0926
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.002 0.0028 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0791 0.3419 0.8932
Onchocerca volvulus 0.0028 0.006 0.0277
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0052 0.0165 0.0361
Loa Loa (eye worm) hypothetical protein 0.0059 0.0196 0.0303
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0014
Echinococcus granulosus tumor protein p63 0.0377 0.1597 0.1594
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0012 0.0008
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0141 0.0561 0.0557
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0056 0.0183 0.3213
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0092 0.0344 0.2535
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0089
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0029 0.0025
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.042 0.1334
Mycobacterium tuberculosis Conserved protein 0.0109 0.042 0.1334
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0533 0.0743
Echinococcus multilocularis microtubule associated protein 2 0.0707 0.3048 0.3045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0533 0.053
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.006 0.0657
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0055 0.0117
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0043 0.0062
Schistosoma mansoni hypothetical protein 0.0029 0.0064 0.0084
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0052 0.0165 0.0801
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0071 0.0251 0.0625
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0114 0.0441 0.1143
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.022 0.2837
Plasmodium vivax hypothetical protein, conserved 0.0109 0.042 0.7474
Onchocerca volvulus 0.0015 0.0004 0.0019
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.002 0.0028 0.0431
Echinococcus multilocularis pyruvate kinase 0.0034 0.0089 0.0085
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0012 0.0008
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0056 0.0183 0.0251
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0116 0.0791
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.042 0.1334
Echinococcus multilocularis muscleblind protein 0.0153 0.0611 0.0607
Giardia lamblia Pyruvate kinase 0.0034 0.0089 0.0391
Echinococcus multilocularis 0.0056 0.0183 0.0179
Mycobacterium tuberculosis Possible penicillin-binding protein 0.07 0.3016 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0165 0.0361
Loa Loa (eye worm) phosphatidylinositol 3 0.1461 0.6366 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.0533 0.053
Plasmodium falciparum importin beta, putative 0.0028 0.006 0.1009
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.016 0.0641 0.0637
Loa Loa (eye worm) phosphatidylinositol 3 0.026 0.1083 0.1697
Brugia malayi Importin beta-1 subunit 0.0028 0.006 0.0148
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0086 0.0316 0.0492
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0141 0.0561 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0056 0.0183 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0441 0.1086
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0012 0.0014
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0116 0.0112
Brugia malayi Pre-SET motif family protein 0.0064 0.022 0.0565
Echinococcus granulosus mitogen activated protein kinase 0.0071 0.0251 0.0247
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.002 0.0028 0.0041
Echinococcus granulosus lamin 0.0028 0.006 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0441 0.1086
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.042 0.107
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0141 0.0561 0.7509
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0034
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0052 0.0165 0.1162
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0884 0.3826 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Echinococcus granulosus ubiquitin specific protease 41 0.0052 0.0165 0.0161
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0111 0.0107
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0056 0.0183 0.0179
Schistosoma mansoni ran 0.002 0.0028 0.0034
Mycobacterium leprae conserved hypothetical protein 0.0109 0.042 1
Mycobacterium leprae conserved hypothetical protein 0.0056 0.0183 0.3507
Onchocerca volvulus 0.0056 0.0183 0.0844
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0183 0.0743 0.5554
Plasmodium vivax ataxin-2 like protein, putative 0.0018 0.002 0.0277
Brugia malayi jmjC domain containing protein 0.0017 0.0012 0.0023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.042 0.0584
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0056 0.0183 0.2336
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0055 0.0114
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0141 0.0561 0.1458
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0116 0.2016
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.002 0.0028 0.0041
Mycobacterium ulcerans lipase LipD 0.0109 0.042 0.3145
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.002 0.0028 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.022 0.0302
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0046 0.014 0.0357
Trypanosoma brucei PAB1-binding protein , putative 0.0018 0.002 0.0055
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0092 0.0344 0.0907
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0116 0.0724
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.042 0.1032
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.002 0.0028 0.0431
Giardia lamblia Kinase, CMGC MAPK 0.0071 0.0251 0.1259
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0056 0.0183 0.0448
Schistosoma mansoni hypothetical protein 0.0052 0.0169 0.0231
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0052 0.0165 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Trichomonas vaginalis importin beta-1, putative 0.0022 0.0037 0.0024
Trichomonas vaginalis set domain proteins, putative 0.0507 0.2169 0.5637
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.026 0.1083 0.2808
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0236 0.0232
Loa Loa (eye worm) hypothetical protein 0.0026 0.0055 0.0081
Echinococcus granulosus tar DNA binding protein 0.013 0.0512 0.0508
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0071 0.0251 0.0389
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0316 0.1328 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0114 0.0441 0.1123
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0316 0.1328 0.3422
Brugia malayi hypothetical protein 0.0137 0.054 0.1403
Plasmodium vivax JmjC domain containing protein 0.0017 0.0012 0.0147
Schistosoma mansoni lipoxygenase 0.0042 0.0122 0.0166
Loa Loa (eye worm) RNA binding protein 0.013 0.0512 0.0799
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0183 0.0408
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0055 0.0234
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0215 0.0211
Echinococcus multilocularis lamin dm0 0.0028 0.006 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.042 0.1032
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0059 0.0196 0.0482
Schistosoma mansoni hypothetical protein 0.0046 0.014 0.0191
Loa Loa (eye worm) hypothetical protein 0.0124 0.0485 0.0757
Echinococcus granulosus pyruvate kinase 0.0034 0.0089 0.0085
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0089 0.0409
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0056 0.0183 0.0251
Echinococcus granulosus importin subunit beta 1 0.0028 0.006 0.0056
Loa Loa (eye worm) doublecortin family protein 0.0015 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0062 0.021 0.0325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.002 0.0277
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0056 0.0183 0.0408
Schistosoma mansoni hypothetical protein 0.0029 0.0064 0.0084
Onchocerca volvulus 0.0507 0.2169 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.006 0.0365
Loa Loa (eye worm) hypothetical protein 0.0029 0.0064 0.0095
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0071 0.0251 0.0625
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.0512 0.0799
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.022 0.0216
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0089 0.0223
Brugia malayi jmjC domain containing protein 0.0017 0.0012 0.0023
Giardia lamblia GTOR 0.0183 0.0743 0.3894
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.042 0.1334
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0183 0.0743 0.1934
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0052 0.0165 0.0419
Leishmania major phosphatidylinositol 4-kinase, putative 0.0056 0.0183 0.0467
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0884 0.3826 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.0069 0.0241 0.0332
Leishmania major phosphatidylinositol kinase related protein, putative 0.0056 0.0183 0.0467
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0029 0.0064 0.006
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0089 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0012 0.0008
Mycobacterium leprae Probable lipase LipE 0.0109 0.042 1
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.042 0.3145
Brugia malayi beta-lactamase family protein 0.0109 0.042 0.109
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0116 0.5
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0141 0.0561 0.0557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Toxoplasma gondii FATC domain-containing protein 0.0114 0.0441 0.5862
Mycobacterium tuberculosis Conserved protein 0.0109 0.042 0.1334
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0056 0.0183 0.1298
Brugia malayi hypothetical protein 0.0225 0.0926 0.2414
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.006 0.0148
Echinococcus granulosus snurportin 1 0.0296 0.1239 0.1235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1635 0.7132 0.7131
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0055 0.007
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0056 0.0183 0.1298
Loa Loa (eye worm) hypothetical protein 0.0026 0.0055 0.0081
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0183 0.0743 0.5554
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0056 0.0183 0.0179
Echinococcus multilocularis mitogen activated protein kinase 3 0.0071 0.0251 0.0247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.0533 0.0743
Brugia malayi RNA, U transporter 1 0.0079 0.0285 0.0736
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.042 0.3101
Brugia malayi hypothetical protein 0.0052 0.0169 0.0432
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.0533 0.1386
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0042 0.0122 0.0118
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.022 0.0216
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0828 0.3581 0.9356
Loa Loa (eye worm) hypothetical protein 0.0109 0.042 0.0655
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0071 0.0251 0.0625
Entamoeba histolytica protein kinase rad3, putative 0.0114 0.0441 0.1086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0183 0.0743 0.2001
Onchocerca volvulus 0.0109 0.042 0.1938
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0183 0.0743 0.1036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0029 0.0064 0.006
Schistosoma mansoni alkaline phosphatase 0.016 0.0641 0.0893
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.042 0.0416
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.0533 0.053
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0316 0.1328 0.3464
Echinococcus multilocularis lamin 0.0028 0.006 0.0056
Onchocerca volvulus 0.0028 0.006 0.0277
Loa Loa (eye worm) hypothetical protein 0.0064 0.022 0.0339
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0056 0.0183 0.0179
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0056 0.0183 0.0251
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0316 0.1328 0.3422
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0183 0.0743 0.1916
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0752 0.3245 0.848
Chlamydia trachomatis pyruvate kinase 0.0034 0.0089 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0141 0.0561 0.0781
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0016 0.0206
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0209 0.0205
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.042 0.1032
Echinococcus granulosus intestinal type alkaline phosphatase 0.016 0.0641 0.0637
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0056 0.0183 0.3213
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0089 0.02
Loa Loa (eye worm) latrophilin receptor protein 2 0.0029 0.0064 0.0095
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0183 0.0743 0.2001
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0236 0.0365
Echinococcus granulosus phd:f box containing protein 0.0017 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0137 0.054 0.0843
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0089 0.016
Leishmania major phosphatidylinositol 3-kinase, putative 0.0141 0.0561 0.1503
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0316 0.1328 0.1857
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0583 0.2503 0.25
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0183 0.0743 0.2001
Loa Loa (eye worm) phosphatidylinositol 3 0.0183 0.0743 0.1162
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0114 0.0441 0.1143
Leishmania major hypothetical protein, unknown function 0.0056 0.0183 0.0467
Echinococcus granulosus microtubule associated protein 2 0.0707 0.3048 0.3045
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0141 0.0561 0.0781
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0114 0.0441 0.0437
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0116 0.0295
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0092 0.0344 0.1078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0183 0.0743 0.1916
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.042 0.0655
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0089 0.0134
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.002 0.0028 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Brugia malayi Calcitonin receptor-like protein seb-1 0.009 0.0336 0.087
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.0251 0.0586
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0236 0.0232
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0056 0.0183 0.0448
Leishmania major phosphatidylinositol kinase, putative 0.0056 0.0183 0.0467
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0071 0.0251 0.0653
Mycobacterium tuberculosis Conserved protein 0.0109 0.042 0.1334
Brugia malayi glutaminase DH11.1 0.0305 0.1281 0.3341
Schistosoma mansoni ap endonuclease 0.004 0.0116 0.0157
Brugia malayi hypothetical protein 0.0015 0.0004 0.0001
Schistosoma mansoni alkaline phosphatase 0.016 0.0641 0.0893
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0052 0.0165 0.0161
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0884 0.3826 1
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0029 0.0025
Echinococcus granulosus survival motor neuron protein 1 0.0225 0.0926 0.0922
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.016 0.0641 0.0637
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0183 0.0743 0.1882
Schistosoma mansoni ran 0.002 0.0028 0.0034
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0056 0.0183 0.0179
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0089 0.0409
Onchocerca volvulus 0.0056 0.0183 0.0844
Plasmodium vivax SET domain protein, putative 0.0064 0.022 0.3869
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0441 0.1086
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0016 0.0045
Schistosoma mansoni hypothetical protein 0.0062 0.021 0.0289
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0016 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.0485 0.1204
Entamoeba histolytica hypothetical protein 0.0056 0.0183 0.0408
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.0251 0.0586
Loa Loa (eye worm) hypothetical protein 0.0027 0.0058 0.0085
Entamoeba histolytica hypothetical protein 0.0052 0.0169 0.037
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0236 0.0547
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0114 0.0441 0.0437
Echinococcus multilocularis pyruvate kinase 0.0034 0.0089 0.0085
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0014
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0089 0.1519
Entamoeba histolytica hypothetical protein 0.0056 0.0183 0.0408
Trichomonas vaginalis CMGC family protein kinase 0.0071 0.0251 0.0586
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0056 0.0183 0.0408
Echinococcus granulosus lamin dm0 0.0028 0.006 0.0056
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0056 0.0183 0.0448
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.022 0.0302
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0116 0.0112
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0884 0.3826 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0141 0.0561 0.1403
Schistosoma mansoni hypothetical protein 0.0083 0.0303 0.042
Schistosoma mansoni mucolipin 0.0069 0.0241 0.0332
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0056 0.0183 0.1298
Schistosoma mansoni survival motor neuron protein 0.0046 0.014 0.0191
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0089 0.0581
Brugia malayi jmjC domain containing protein 0.0063 0.0215 0.0554
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0056 0.0183 0.0408
Echinococcus multilocularis serine protein kinase ATM 0.0114 0.0441 0.0437
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0116 0.2016
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0089 0.1046
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0884 0.3826 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.042 0.0584
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0042 0.0122 0.0118
Onchocerca volvulus 0.0046 0.014 0.0646
Echinococcus multilocularis pyruvate kinase 0.0018 0.0016 0.0011
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0583 0.2503 0.25
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0055 0.0181 0.0279
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0089 0.0581
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0055 0.007
Trichomonas vaginalis esterase, putative 0.0109 0.042 0.1032
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.042 0.1334
Schistosoma mansoni tar DNA-binding protein 0.013 0.0512 0.0712
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0236 0.0586
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0055 0.0134
Echinococcus granulosus intermediate filament protein 0.0028 0.006 0.0056
Echinococcus multilocularis tumor protein p63 0.0377 0.1597 0.1594
Trichomonas vaginalis glutaminase, putative 0.0305 0.1281 0.3298
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0116 0.5
Echinococcus multilocularis intestinal type alkaline phosphatase 0.016 0.0641 0.0637
Schistosoma mansoni glutaminase 0.0305 0.1281 0.1791
Brugia malayi Latrophilin receptor protein 2 0.0029 0.0064 0.0159
Schistosoma mansoni pyruvate kinase 0.0018 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0743 0.1882
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0215 0.0211
Schistosoma mansoni ap endonuclease 0.004 0.0116 0.0157
Loa Loa (eye worm) hypothetical protein 0.0056 0.0183 0.0282
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0089 0.0504
Mycobacterium ulcerans hypothetical protein 0.0109 0.042 0.3145
Echinococcus granulosus mucolipin 3 0.0069 0.0241 0.0237

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) Antiparasitic activity against Toxoplasma gondii in human foreskin fibroblast by beta-galactosidase assay ChEMBL. 16643061

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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