Detailed information for compound 1048426

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 596.2 | Formula: C32H34ClNO4S2
  • H donors: 1 H acceptors: 2 LogP: 5.65 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)[C@@H]1CCCN(C1)CCC=C(c1sccc1COc1ccccc1)c1sccc1COc1ccccc1.Cl
  • InChi: 1S/C32H33NO4S2.ClH/c34-32(35)24-9-7-17-33(21-24)18-8-14-29(30-25(15-19-38-30)22-36-27-10-3-1-4-11-27)31-26(16-20-39-31)23-37-28-12-5-2-6-13-28;/h1-6,10-16,19-20,24H,7-9,17-18,21-23H2,(H,34,35);1H/t24-;/m1./s1
  • InChiKey: WCWMZHOYBDOGPU-GJFSDDNBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_126944 All targets in OG5_126944
Schistosoma japonicum Sodium- and chloride-dependent creatine transporter 1, putative Get druggable targets OG5_126944 All targets in OG5_126944
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_126944 All targets in OG5_126944
Echinococcus multilocularis sodium:chloride dependent neurotransmitter Get druggable targets OG5_126944 All targets in OG5_126944
Schistosoma japonicum Sodium- and chloride-dependent GABA transporter 2, putative Get druggable targets OG5_126944 All targets in OG5_126944
Echinococcus granulosus sodium:chloride dependent neurotransmitter Get druggable targets OG5_126944 All targets in OG5_126944
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter Get druggable targets OG5_126944 All targets in OG5_126944
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Get druggable targets OG5_126944 All targets in OG5_126944
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_126944 All targets in OG5_126944
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126944 All targets in OG5_126944
Schistosoma japonicum ko:K10420 dynein light chain Tctex-type 1, putative Get druggable targets OG5_126944 All targets in OG5_126944
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter Get druggable targets OG5_126944 All targets in OG5_126944
Schistosoma japonicum Sodium- and chloride-dependent GABA transporter 3, putative Get druggable targets OG5_126944 All targets in OG5_126944
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter Get druggable targets OG5_126944 All targets in OG5_126944
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126944 All targets in OG5_126944
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative solute carrier family 6 (neurotransmitter transporter), member 1 599 aa 606 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone lysine methyltransferase setb 0.0138 0.0236 0.0363
Brugia malayi Smad1 0.0052 0.005 0.0069
Loa Loa (eye worm) hypothetical protein 0.0518 0.1058 0.5972
Echinococcus multilocularis chromobox protein 1 0.0222 0.0419 0.065
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1272 0.2686 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0017 0.0081
Loa Loa (eye worm) TAR-binding protein 0.0204 0.0378 0.2133
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0094
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0241 0.0459 0.1681
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0138 0.0236 0.0363
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0518 0.1058 0.6187
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0102 0.0158 0.0565
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0244 0.0466 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0352 0.2057
Brugia malayi CHD4 protein 0.0046 0.0037 0.005
Loa Loa (eye worm) MH2 domain-containing protein 0.076 0.1581 0.8918
Schistosoma mansoni hypothetical protein 0.0269 0.0519 0.0805
Loa Loa (eye worm) hypothetical protein 0.0049 0.0044 0.0249
Echinococcus granulosus dnaJ subfamily B 0.1276 0.2696 0.4241
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0046 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0113 0.0646
Trypanosoma brucei N-myristoyl transferase, putative 0.0815 0.17 0.6318
Trichomonas vaginalis chromobox protein, putative 0.0134 0.0228 0.1325
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0269 0.0519 0.0808
Plasmodium vivax telomerase reverse transcriptase, putative 0.1272 0.2686 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Mycobacterium ulcerans DNA polymerase I 0.0244 0.0466 1
Loa Loa (eye worm) transcription factor SMAD2 0.076 0.1581 0.8918
Onchocerca volvulus 0.0036 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.0273 0.0527 0.2974
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Echinococcus granulosus chromobox protein 1 0.0222 0.0419 0.065
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0016 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0037 0.0198
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0049 0.0783
Loa Loa (eye worm) hypothetical protein 0.0125 0.0207 0.117
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0081 0.0113 0.0164
Toxoplasma gondii isocitrate dehydrogenase 0.0067 0.0083 0.0288
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Leishmania major C-8 sterol isomerase-like protein 0.0382 0.0765 0.2824
Plasmodium falciparum ataxin-2 like protein, putative 0.0133 0.0226 0.082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.0362 0.0562
Leishmania major hypothetical protein, conserved 0.0035 0.0015 0.0023
Loa Loa (eye worm) patched family protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0082
Loa Loa (eye worm) hypothetical protein 0.0321 0.0631 0.356
Brugia malayi Latrophilin receptor protein 2 0.0269 0.0519 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0219 0.1273
Toxoplasma gondii histone lysine methyltransferase SET1 0.0178 0.0324 0.1185
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0045 0.0062
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1272 0.2686 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0138 0.0236 0.0359
Plasmodium falciparum plastid replication-repair enzyme 0.0071 0.0091 0.0317
Schistosoma mansoni hypothetical protein 0.0214 0.0402 0.062
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0241 0.0459 0.1681
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0046 0.0037 0.0125
Toxoplasma gondii FATC domain-containing protein 0.0046 0.0037 0.0114
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0018 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0014 0.0066
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0067 0.0083 0.0122
Loa Loa (eye worm) hypothetical protein 0.058 0.1192 0.6725
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0241 0.0459 0.0714
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0061 0.034
Loa Loa (eye worm) hypothetical protein 0.0035 0.0014 0.008
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0015 0.0032
Trichomonas vaginalis chromobox protein, putative 0.0134 0.0228 0.1325
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0036 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Trypanosoma cruzi target of rapamycin kinase 3 0.0192 0.0352 0.1303
Loa Loa (eye worm) RNA binding protein 0.0204 0.0378 0.2133
Brugia malayi Niemann-Pick C1 protein precursor 0.0518 0.1058 0.146
Plasmodium vivax heterochromatin protein 1, putative 0.0036 0.0017 0.004
Echinococcus granulosus geminin 0.1254 0.2648 0.4165
Loa Loa (eye worm) hypothetical protein 0.0123 0.0203 0.1148
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.0219 0.4545
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0015 0.0024
Schistosoma mansoni smad 0.0052 0.005 0.0066
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0125 0.0207 0.0201
Schistosoma mansoni hypothetical protein 0.1276 0.2696 0.4239
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0015 0.0023
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0017 0.0081
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0526 0.1076 0.1683
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0082
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.0085 0.0122 0.0432
Echinococcus granulosus Protein patched homolog 1 0.0222 0.0419 0.0651
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0241 0.0459 0.1681
Trichomonas vaginalis DNA polymerase I, putative 0.0071 0.0091 0.0518
Loa Loa (eye worm) hypothetical protein 0.0195 0.0361 0.2034
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0067 0.0083 0.028
Brugia malayi Associated with TFs and helicases family protein 0.0036 0.0017 0.0023
Loa Loa (eye worm) Smad1 0.0052 0.005 0.0282
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0101
Loa Loa (eye worm) helicase 0.0036 0.0017 0.0094
Brugia malayi Bromodomain containing protein 0.0081 0.0114 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.0325 0.1898
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0094
Entamoeba histolytica hypothetical protein 0.0225 0.0425 0.2424
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.0815 0.17 0.2671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0249 0.145
Loa Loa (eye worm) glutathione reductase 0.0051 0.0049 0.0276
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0018 0.0044
Trypanosoma brucei C-8 sterol isomerase, putative 0.0382 0.0765 0.2824
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0036 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.058 0.1192 0.1867
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0015 0.0069
Schistosoma mansoni hypothetical protein 0.0052 0.0051 0.0067
Trypanosoma cruzi PAB1-binding protein , putative 0.0133 0.0226 0.0831
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0045 0.0671
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0081 0.0113 0.0389
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0015 0.0069
Schistosoma mansoni hypothetical protein 0.0225 0.0425 0.0657
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0269 0.0519 0.0808
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0219 0.1271
Brugia malayi chromobox protein homolog 3 0.0125 0.0207 0.0286
Brugia malayi MH2 domain containing protein 0.0052 0.005 0.0069
Loa Loa (eye worm) phosphatidylinositol 3 0.0241 0.0459 0.2587
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0123 0.0203 0.0308
Echinococcus multilocularis Chromobox protein 3 0.0036 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.0325 0.1898
Trypanosoma brucei N-myristoyltransferase 0.0815 0.17 0.6318
Leishmania major mitochondrial DNA polymerase I protein A, putative 0.0071 0.0091 0.0308
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0019 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0249 0.145
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0244 0.0466 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Brugia malayi Pre-SET motif family protein 0.0696 0.1443 0.199
Loa Loa (eye worm) N-myristoyltransferase 2 0.0815 0.17 0.9594
Mycobacterium tuberculosis Conserved protein 0.0035 0.0015 0.0024
Schistosoma mansoni hypothetical protein 0.0269 0.0519 0.0805
Loa Loa (eye worm) hypothetical protein 0.0138 0.0236 0.1331
Loa Loa (eye worm) CXXC zinc finger family protein 0.009 0.0132 0.0743
Brugia malayi hypothetical protein 0.0031 0.0006 0.0008
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0173 0.0313 0.1138
Echinococcus granulosus tar DNA binding protein 0.0204 0.0378 0.0587
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0045 0.0062
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0101
Schistosoma mansoni bromodomain containing protein 0.014 0.024 0.0365
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0071 0.0091 0.0328
Toxoplasma gondii thioredoxin reductase 0.0051 0.0049 0.016
Brugia malayi latrophilin 2 splice variant baaae 0.058 0.1192 0.1644
Echinococcus granulosus zinc finger protein 0.0047 0.0039 0.0052
Trichomonas vaginalis Heterochromatin protein, putative 0.0036 0.0017 0.0081
Brugia malayi FAT domain containing protein 0.0035 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0269 0.0519 0.2925
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Plasmodium falciparum glutathione reductase 0.0051 0.0049 0.016
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Schistosoma mansoni hypothetical protein 0.0269 0.0519 0.0805
Loa Loa (eye worm) patched family protein 0.0031 0.0006 0.0034
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0269 0.0519 0.0715
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.0325 0.1898
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0018 0.0096
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0016 0.0017
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0051 0.0048 0.0156
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.0362 0.0562
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0129 0.0741
Loa Loa (eye worm) hypothetical protein 0.0082 0.0114 0.0645
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0015 0.0069
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0045 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.0419 0.245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.0382 0.2236
Plasmodium falciparum heterochromatin protein 1 0.0036 0.0017 0.004
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0046 0.0037 0.0044
Entamoeba histolytica hypothetical protein 0.0046 0.0037 0.0118
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0378 0.0583
Echinococcus granulosus Smad4 0.0052 0.005 0.007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0102 0.0158 0.0235
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0045 0.0671
Plasmodium falciparum thioredoxin reductase 0.0051 0.0049 0.016
Leishmania major phosphatidylinositol 3-kinase, putative 0.0081 0.0113 0.0389
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0052 0.005 0.007
Echinococcus granulosus Niemann Pick C1 protein 0.0741 0.1539 0.2417
Trypanosoma cruzi ISWI complex protein 0.0033 0.0008 0.002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0849 0.1772 0.2444
Loa Loa (eye worm) hypothetical protein 0.0049 0.0045 0.0253
Echinococcus granulosus TGF beta signal transducer SmadC 0.0052 0.005 0.007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0045 0.0253
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0138 0.0236 0.0359
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0015 0.0024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0269 0.0519 0.0808
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0378 0.0583
Brugia malayi Thioredoxin reductase 0.0051 0.0049 0.0067
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0017 0.0013
Mycobacterium ulcerans 5'-3' exonuclease 0.0173 0.0313 0.6614
Loa Loa (eye worm) hypothetical protein 0.003 0.0003 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0225 0.0425 0.0657
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0113 0.0635
Entamoeba histolytica hypothetical protein 0.0225 0.0425 0.2424
Echinococcus multilocularis GPCR, family 2 0.0269 0.0519 0.0808
Toxoplasma gondii RNA-directed DNA polymerase 0.1272 0.2686 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0061 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0352 0.2057
Leishmania major trypanothione reductase 0.0051 0.0049 0.0151
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0082
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0045 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.004 0.022
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0036 0.0017 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0156 0.0276 0.1608
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0129 0.0741
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0018 0.0072
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0103 0.0153
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0015 0.0024
Trichomonas vaginalis set domain proteins, putative 0.0792 0.165 0.9706
Echinococcus granulosus sterol regulatory element binding protein 0.0222 0.0419 0.0651
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0067 0.0083 0.0299
Brugia malayi DNA polymerase I family protein 0.0071 0.0091 0.0125
Loa Loa (eye worm) MH1 domain-containing protein 0.0052 0.005 0.0282
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0241 0.0459 0.0632
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0045 0.0136
Onchocerca volvulus 0.0321 0.0631 0.0625
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0045 0.0136
Loa Loa (eye worm) hypothetical protein 0.015 0.0263 0.1483
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Brugia malayi Bromodomain containing protein 0.0164 0.0294 0.0405
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0036 0.0017 0.0023
Trypanosoma brucei trypanothione reductase 0.0051 0.0049 0.0151
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0094
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.0191 0.3922
Brugia malayi Valyl-tRNA synthetase 0.0036 0.0017 0.0023
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0067 0.0083 0.0122
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0241 0.0459 0.071
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0045 0.0671
Brugia malayi Isocitrate dehydrogenase 0.0067 0.0083 0.0115
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0094
Echinococcus multilocularis Smad4 0.0052 0.005 0.007
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Echinococcus multilocularis microtubule associated protein 2 0.2966 0.6349 1
Schistosoma mansoni hypothetical protein 0.0036 0.0017 0.0013
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0101
Echinococcus granulosus smad 0.0052 0.005 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0123 0.0203 0.0311
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0061 0.034
Brugia malayi MH1 domain containing protein 0.0052 0.005 0.0069
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0173 0.0313 0.1155
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0696 0.1443 0.8142
Entamoeba histolytica hypothetical protein 0.0225 0.0425 0.2424
Trypanosoma cruzi PAB1-binding protein , putative 0.0133 0.0226 0.0831
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0037 0.0198
Onchocerca volvulus 0.0049 0.0045 0.0039
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Trichomonas vaginalis N-myristoyl transferase, putative 0.0536 0.1096 0.6439
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0081 0.0113 0.0168
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0382 0.0765 0.1054
Giardia lamblia CDC72 0.0815 0.17 0.5574
Echinococcus multilocularis protein dispatched 1 0.0254 0.0487 0.0758
Schistosoma mansoni zinc finger protein 0.0047 0.0039 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0219 0.1273
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0045 0.0671
Loa Loa (eye worm) hypothetical protein 0.0051 0.0048 0.027
Trichomonas vaginalis N-myristoyl transferase, putative 0.0815 0.17 1
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.0815 0.17 1
Schistosoma mansoni chromobox protein 0.0222 0.0419 0.0647
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.0246 0.1432
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0049 0.0068
Brugia malayi RNA recognition motif domain containing protein 0.0204 0.0378 0.0521
Brugia malayi Heterochromatin protein 1 0.0222 0.0419 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0142 0.0246 0.1432
Brugia malayi M-phase phosphoprotein, mpp8 0.0036 0.0017 0.0023
Brugia malayi Patched protein homolog 1 0.0031 0.0006 0.0008
Entamoeba histolytica DNA-directed DNA polymerase, putative 0.0071 0.0091 0.044
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0067 0.0083 0.1543
Loa Loa (eye worm) latrophilin receptor protein 2 0.0269 0.0519 0.2925
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.0325 0.1898
Entamoeba histolytica protein kinase rad3, putative 0.0046 0.0037 0.0118
Echinococcus multilocularis Niemann Pick C1 protein 0.0518 0.1058 0.1659
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0071 0.0091 0.0308
Echinococcus multilocularis Chromo domain 0.0036 0.0017 0.0017
Onchocerca volvulus 0.0098 0.0149 0.0143
Schistosoma mansoni N-myristoyltransferase 0.0815 0.17 0.2669
Schistosoma mansoni hypothetical protein 0.0035 0.0014 0.0009
Echinococcus granulosus Chromo domain 0.0036 0.0017 0.0017
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0196 0.0362 0.0499
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0046 0.0037 0.0048
Brugia malayi RNA binding protein 0.0204 0.0378 0.0521
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0269 0.0519 0.0808
Mycobacterium tuberculosis Probable reductase 0.0117 0.0191 0.3922
Schistosoma mansoni fkbp-rapamycin associated protein 0.0046 0.0037 0.0044
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Onchocerca volvulus 0.0138 0.0236 0.023
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0046 0.0037 0.0125
Loa Loa (eye worm) hypothetical protein 0.0849 0.1772 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0134 0.0228 0.0222
Trichomonas vaginalis chromobox protein, putative 0.0222 0.0419 0.2448
Leishmania major telomerase reverse transcriptase, putative 0.1272 0.2686 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0046 0.0037 0.0105
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0067 0.0083 0.0288
Schistosoma mansoni hypothetical protein 0.1254 0.2648 0.4163
Brugia malayi hypothetical protein 0.0225 0.0425 0.0586
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.0325 0.1898
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.0815 0.17 0.6321
Brugia malayi CXXC zinc finger family protein 0.009 0.0132 0.0182
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0082
Echinococcus multilocularis tumor protein p63 0.219 0.4672 0.7356
Onchocerca volvulus 0.0035 0.0015 0.0009
Toxoplasma gondii DNA polymerase I domain-containing protein 0.0071 0.0091 0.0317
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0045 0.0136
Loa Loa (eye worm) heterochromatin protein 1 0.0222 0.0419 0.2361
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.0191 0.3922
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0015 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0378 0.0583
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.0191 0.3922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0113 0.0646
Entamoeba histolytica hypothetical protein 0.0225 0.0425 0.2424
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.0017 0.004
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0016 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0219 0.1271
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0061 0.034
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0082
Loa Loa (eye worm) hypothetical protein 0.0096 0.0145 0.0818
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0094
Trypanosoma cruzi N-myristoyl transferase, putative 0.0815 0.17 0.6326
Schistosoma mansoni hypothetical protein 0.0044 0.0033 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0113 0.0646
Echinococcus multilocularis geminin 0.1254 0.2648 0.4165
Brugia malayi beta-lactamase 0.0035 0.0015 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.0362 0.0558
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.0191 0.3922
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0192 0.0352 0.1285
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0037 0.005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0138 0.0236 0.0359
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0017 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0113 0.0646
Echinococcus multilocularis twinkle protein, mitochondrial 0.0052 0.0051 0.0071
Loa Loa (eye worm) hypothetical protein 0.0087 0.0125 0.0706
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0241 0.0459 0.2624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0352 0.2057
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0241 0.0459 0.2624
Echinococcus multilocularis smad 0.0052 0.005 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0219 0.1273
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0046 0.0037 0.0118
Echinococcus multilocularis mothers against decapentaplegic 5 0.0052 0.005 0.007
Echinococcus multilocularis Niemann Pick C1 protein 0.0741 0.1539 0.2417
Loa Loa (eye worm) hypothetical protein 0.0123 0.0203 0.1148
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0049 0.0171
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Echinococcus multilocularis expressed conserved protein 0.0487 0.0991 0.1552
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.0191 0.3922
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0219 0.1271
Loa Loa (eye worm) MH2 domain-containing protein 0.0052 0.005 0.0282
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0017 0.004
Schistosoma mansoni hypothetical protein 0.0269 0.0519 0.0805
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0049 0.0276
Brugia malayi Patched related family protein 10 0.0031 0.0006 0.0008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0067 0.0083 0.0122
Brugia malayi protein C24B5.3 0.0031 0.0006 0.0008
Echinococcus granulosus tumor protein p63 0.219 0.4672 0.7356
Schistosoma mansoni hypothetical protein 0.0052 0.0051 0.0067
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0081 0.0113 0.0168
Brugia malayi Patched related family protein 12 0.0031 0.0006 0.0008
Brugia malayi isocitrate dehydrogenase 0.0067 0.0083 0.0115
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0082
Loa Loa (eye worm) CHromoDomain protein family member 0.0046 0.0037 0.0206
Brugia malayi hypothetical protein 0.0031 0.0006 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0045 0.0671
Mycobacterium tuberculosis Conserved protein 0.0035 0.0015 0.0024
Brugia malayi TAR-binding protein 0.0204 0.0378 0.0521
Brugia malayi hypothetical protein 0.0031 0.0006 0.0008
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.0815 0.17 0.2671
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.0219 0.4532
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1656 0.3517 0.5536
Echinococcus granulosus chromobox protein 1 0.0222 0.0419 0.065
Schistosoma mansoni hypothetical protein 0.0214 0.0402 0.062
Echinococcus granulosus Niemann Pick C1 protein 0.0518 0.1058 0.1659
Schistosoma mansoni smad1 5 8 and 0.0052 0.005 0.0066
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0081 0.0113 0.0409
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0225 0.0425 0.066
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0067 0.0083 0.028
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0194 0.0357 0.0549
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0067 0.0083 0.0118
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0173 0.0313 0.1138
Toxoplasma gondii target of rapamycin (TOR), putative 0.0179 0.0325 0.1191
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0132 0.0223 0.0343
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.0219 0.4545
Brugia malayi PHD-finger family protein 0.0058 0.0064 0.0088
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Loa Loa (eye worm) isocitrate dehydrogenase 0.0067 0.0083 0.047
Schistosoma mansoni DNA polymerase I 0.0071 0.0091 0.013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.0362 0.0562
Echinococcus multilocularis dnaJ subfamily B 0.1276 0.2696 0.4241
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0015 0.0024
Mycobacterium ulcerans hypothetical protein 0.0049 0.0045 0.0671
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.0362 0.0562
Chlamydia trachomatis DNA polymerase I 0.0244 0.0466 1
Echinococcus multilocularis cpg binding protein 0.0099 0.0152 0.023
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0015 0.0069
Plasmodium vivax ataxin-2 like protein, putative 0.0133 0.0226 0.082
Toxoplasma gondii LsmAD domain-containing protein 0.0133 0.0226 0.082
Brugia malayi CHE-14 protein 0.0222 0.0419 0.0578
Schistosoma mansoni patched 1 0.0222 0.0419 0.0647
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0045 0.0693
Leishmania major hypothetical protein, conserved 0.0133 0.0226 0.0812
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0052 0.005 0.0066
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.01 0.0154 0.0545
Loa Loa (eye worm) patched family protein 0.0031 0.0006 0.0034
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0241 0.0459 0.0714
Loa Loa (eye worm) hypothetical protein 0.0046 0.0037 0.0206
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0017 0.0081
Giardia lamblia Telomerase catalytic subunit 0.1272 0.2686 1
Trypanosoma cruzi N-myristoyl transferase, putative 0.0815 0.17 0.6326
Echinococcus granulosus Chromobox protein 3 0.0036 0.0017 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0015 0.001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0049 0.0068
Echinococcus multilocularis sterol regulatory element binding protein 0.0222 0.0419 0.0651
Brugia malayi hypothetical protein 0.0036 0.0017 0.0023
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0113 0.0155
Loa Loa (eye worm) hypothetical protein 0.0382 0.0765 0.4314
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0017 0.0081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0061 0.034
Onchocerca volvulus 0.009 0.0132 0.0126
Onchocerca volvulus 0.0035 0.0015 0.0009
Echinococcus granulosus cpg binding protein 0.0099 0.0152 0.023
Trypanosoma brucei PAB1-binding protein , putative 0.0133 0.0226 0.0812
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0035 0.0014 0.0013
Schistosoma mansoni Smad4 0.0052 0.005 0.0066
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.0815 0.17 0.6321
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0173 0.0313 0.1145
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0102 0.0158 0.0239
Brugia malayi hypothetical protein 0.0031 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0791 0.1647 0.9295
Schistosoma mansoni cellular tumor antigen P53 0.0321 0.0631 0.0982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0241 0.0459 0.2684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0241 0.0459 0.2684
Echinococcus granulosus expressed conserved protein 0.0487 0.0991 0.1552
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Schistosoma mansoni hypothetical protein 0.1254 0.2648 0.4163
Toxoplasma gondii ABC1 family protein 0.0035 0.0015 0.0032
Schistosoma mansoni hypothetical protein 0.0214 0.0402 0.062
Trichomonas vaginalis chromobox protein, putative 0.0222 0.0419 0.2448
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Loa Loa (eye worm) patched family protein 0.0031 0.0006 0.0034
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.006 0.0067 0.0097
Onchocerca volvulus 0.0036 0.0017 0.0011
Leishmania major N-myristoyl transferase, putative 0.0815 0.17 0.6318
Plasmodium falciparum ataxin-2 like protein, putative 0.0133 0.0226 0.082
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0067 0.0083 0.0122
Echinococcus granulosus microtubule associated protein 2 0.2966 0.6349 1
Brugia malayi protein C24B5.3 0.0031 0.0006 0.0008
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0081 0.0113 0.0389
Echinococcus granulosus chromobox protein 2 0.0036 0.0017 0.0017
Brugia malayi Telomerase reverse transcriptase 0.3384 0.7252 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.0226 0.1274
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0352 0.2057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0045 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0207 0.1204
Brugia malayi Patched related family protein 4 0.0031 0.0006 0.0008
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0015 0.0014
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0204 0.0378 0.2133
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0123 0.0203 0.0308
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0017 0.0081
Brugia malayi glutathione reductase 0.0051 0.0049 0.0067
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0114 0.0184 0.0657
Echinococcus multilocularis protein patched 0.0222 0.0419 0.0651
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.006 0.0067 0.0097
Brugia malayi hypothetical protein 0.0133 0.0226 0.0311
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0061 0.034
Echinococcus multilocularis isocitrate dehydrogenase 0.0067 0.0083 0.0122
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0849 0.1772 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.0427 0.9138
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Onchocerca volvulus 0.0792 0.165 0.1645
Trichomonas vaginalis esterase, putative 0.0035 0.0015 0.0069
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0123 0.0203 0.0308
Loa Loa (eye worm) hypothetical protein 0.0098 0.0149 0.0842
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0222 0.0419 0.2363
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0037 0.005
Trypanosoma brucei telomerase reverse transcriptase 0.1272 0.2686 1
Echinococcus granulosus GPCR family 2 0.0269 0.0519 0.0808
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0382 0.0765 0.2838
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0015 0.0082
Schistosoma mansoni smad1 5 8 and 0.0052 0.005 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0078 0.0441
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0045 0.0167
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Brugia malayi MH2 domain containing protein 0.0052 0.005 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0015 0.0043
Schistosoma mansoni smad1 5 8 and 0.0052 0.005 0.0066
Mycobacterium tuberculosis Conserved protein 0.0035 0.0015 0.0024
Schistosoma mansoni chromobox protein 0.0222 0.0419 0.0647
Plasmodium vivax glutathione reductase, putative 0.0051 0.0049 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0162 0.0287 0.1675
Schistosoma mansoni cpg binding protein 0.0099 0.0152 0.0226
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0047 0.004 0.022
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0036 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.0325 0.1898
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0017 0.004
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0045 0.0671
Loa Loa (eye worm) twinkle helicase 0.0052 0.0051 0.0287
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0015 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.0362 0.0558
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0067 0.0083 0.0299
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0192 0.0352 0.1285
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0378 0.0583
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0132 0.0223 0.0343
Loa Loa (eye worm) hypothetical protein 0.0222 0.0419 0.2363
Brugia malayi SET domain containing protein 0.0042 0.0029 0.004
Echinococcus multilocularis chromobox protein 1 0.0222 0.0419 0.065
Loa Loa (eye worm) hypothetical protein 0.0071 0.0091 0.0513
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0101
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.0033 0.0185
Echinococcus multilocularis chromobox protein 2 0.0036 0.0017 0.0017
Brugia malayi MH2 domain containing protein 0.076 0.1581 0.218
Schistosoma mansoni cpg binding protein 0.009 0.0132 0.0195
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0045 0.0671
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0081 0.0113 0.0409
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.0191 0.3907
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0015 0.0014
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0241 0.0459 0.1698
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0123 0.0203 0.0311
Echinococcus granulosus mothers against decapentaplegic 5 0.0052 0.005 0.007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0037 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0144 0.0249 0.145
Loa Loa (eye worm) hypothetical protein 0.0049 0.0045 0.0253
Plasmodium vivax plastid replication-repair enzyme, putative 0.0071 0.0091 0.0317
Schistosoma mansoni cpg binding protein 0.0099 0.0152 0.0226
Plasmodium vivax SET domain protein, putative 0.0102 0.0158 0.0565
Brugia malayi N-myristoyltransferase 2 0.0815 0.17 0.2345
Echinococcus granulosus serine protein kinase ATM 0.0046 0.0037 0.0048
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Trichomonas vaginalis hypothetical protein 0.0036 0.0017 0.0081
Schistosoma mansoni chromobox protein 0.0036 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0015 0.001
Schistosoma mansoni hypothetical protein 0.006 0.0067 0.0093
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0067 0.0083 0.028
Echinococcus multilocularis zinc finger protein 0.0047 0.0039 0.0052
Echinococcus multilocularis tar DNA binding protein 0.0204 0.0378 0.0587
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0061 0.034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0045 0.0693
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0015 0.0024
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0173 0.0313 0.1145
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0173 0.0313 0.1155
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0196 0.0362 0.2043
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) beta-lactamase 0.0035 0.0015 0.0082
Plasmodium falciparum telomerase reverse transcriptase 0.1272 0.2686 1
Onchocerca volvulus 0.0035 0.0015 0.0009
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0071 0.0091 0.0328
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Echinococcus granulosus fetal alzheimer antigen falz 0.0053 0.0053 0.0074
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0014 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192 0.0352 0.2057
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.0219 0.1273
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0015 0.0043
Loa Loa (eye worm) histone methyltransferase 0.0031 0.0006 0.0033
Brugia malayi Pre-SET motif family protein 0.0102 0.0158 0.0217
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0067 0.0083 0.0288
Trypanosoma cruzi ISWI complex protein 0.0033 0.0008 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0048 0.0264
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0053 0.0053 0.0074
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0015 0.0069
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0081 0.0113 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0207 0.1204
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0067 0.0083 0.0122
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0036 0.0017 0.004
Schistosoma mansoni chromobox protein 0.0036 0.0017 0.0013
Brugia malayi Patched family protein 0.0031 0.0006 0.0008
Echinococcus granulosus twinkle protein mitochondrial 0.0052 0.0051 0.0071
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Toxoplasma gondii helicase, putative 0.0071 0.0091 0.0317
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0061 0.034
Echinococcus multilocularis serine protein kinase ATM 0.0046 0.0037 0.0048
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0071 0.0091 0.0308
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0036 0.0017 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0081
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0045 0.0167
Onchocerca volvulus Twinkle protein, mitochondrial homolog 0.0052 0.0051 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0241 0.0459 0.2684
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0035 0.0014 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0037 0.0198
Brugia malayi Myosin head containing protein 0.0031 0.0006 0.0008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0225 0.0425 0.066
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0378 0.0583
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0016 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0179 0.0325 0.1898
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0094
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0015 0.002
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.0017 0.004
Brugia malayi hypothetical protein 0.0791 0.1647 0.2272
Treponema pallidum DNA polymerase I (polA) 0.0244 0.0466 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0096 0.0145 0.022
Toxoplasma gondii isocitrate dehydrogenase 0.0067 0.0083 0.0288
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.0362 0.0558
Brugia malayi MH1 domain containing protein 0.0052 0.005 0.0069
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Brugia malayi Protein cec-1. 0.0036 0.0017 0.0023
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0046 0.0037 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0113 0.0646
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0241 0.0459 0.1698
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0017 0.0013
Brugia malayi beta-lactamase family protein 0.0035 0.0015 0.002
Loa Loa (eye worm) patched family protein 0.0031 0.0006 0.0034
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.0173 0.0313 0.6622
Brugia malayi hypothetical protein 0.0086 0.0124 0.0171
Schistosoma mansoni hypothetical protein 0.0214 0.0402 0.062
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.0219 0.4545
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0053 0.0053 0.007
Loa Loa (eye worm) hypothetical protein 0.0031 0.0006 0.0034
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0046 0.0037 0.0048
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0241 0.0459 0.1681
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0049 0.016
Brugia malayi beta-lactamase family protein 0.0035 0.0015 0.002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0103 0.0153
Onchocerca volvulus 0.0791 0.1647 0.1642
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0849 0.1772 0.2444
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0244 0.0466 0.5
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0045 0.0167
Schistosoma mansoni microtubule-associated protein tau 0.2966 0.6349 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0046 0.0037 0.0044

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.34 uM Inhibition of GAT1 transport activity ChEMBL. 16246548

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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