Detailed information for compound 1055959

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 364.481 | Formula: C23H28N2O2
  • H donors: 1 H acceptors: 1 LogP: 4.91 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1c1occ(n1)CNCc1ccc(cc1)C(C)(C)C
  • InChi: 1S/C23H28N2O2/c1-5-26-21-9-7-6-8-20(21)22-25-19(16-27-22)15-24-14-17-10-12-18(13-11-17)23(2,3)4/h6-13,16,24H,5,14-15H2,1-4H3
  • InChiKey: GAZVKKFWZJRHHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0419 0.0279 0.1282
Schistosoma mansoni kinase 0.0096 0.005 0.0074
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.001 0.0048
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0028 0.011
Schistosoma mansoni cathepsin C 0.0419 0.0279 0.0409
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0419 0.0279 0.1282
Toxoplasma gondii aspartyl protease 0.0572 0.0388 0.1775
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0028 0.0041
Brugia malayi beta-lactamase 0.0039 0.001 0.0039
Brugia malayi Pepsin A precursor 0.0572 0.0388 0.1517
Leishmania major cathepsin L-like protease 0.1106 0.0767 0.3557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0697 0.0477 0.0699
Mycobacterium tuberculosis Conserved protein 0.0039 0.001 0.0005
Echinococcus multilocularis tumor protein p63 0.0262 0.0168 0.0657
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.001 0.0005
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0119 0.0067 0.0261
Plasmodium falciparum serine repeat antigen 6 0.0419 0.0279 0.3465
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Treponema pallidum fructose-bisphosphate aldolase 0.1886 0.132 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Loa Loa (eye worm) hypothetical protein 0.0148 0.0087 0.034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Echinococcus granulosus tumor protein p63 0.0262 0.0168 0.0657
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0008 0.0033
Brugia malayi Eukaryotic aspartyl protease family protein 0.0572 0.0388 0.1517
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0321 0.021 0.0822
Leishmania major cathepsin L-like protease 0.1106 0.0767 0.3557
Echinococcus granulosus microtubule associated protein 2 0.2271 0.1593 0.6232
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Echinococcus granulosus histone lysine methyltransferase setb 0.0094 0.0049 0.0192
Plasmodium vivax unspecified product 0.0279 0.018 0.2245
Loa Loa (eye worm) hypothetical protein 0.0827 0.0569 0.2226
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1106 0.0767 0.2999
Brugia malayi cathepsin L precursor 0.0419 0.0279 0.1093
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0419 0.0279 0.0409
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0028 0.0041
Mycobacterium ulcerans beta-lactamase 0.0039 0.001 0.0048
Brugia malayi Peptidase family M1 containing protein 0.0031 0.0005 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0119 0.0067 0.0261
Entamoeba histolytica cysteine proteinase, putative 0.0697 0.0477 0.3591
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Echinococcus multilocularis ecdysone induced protein 78C 0.0044 0.0014 0.0053
Entamoeba histolytica cysteine protease, putative 0.0419 0.0279 0.2089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0049 0.0072
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0419 0.0279 0.356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0827 0.0569 0.2635
Echinococcus granulosus muscleblind protein 0.0148 0.0087 0.034
Plasmodium falciparum plasmepsin I 0.0791 0.0544 0.7009
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0044 0.0014 0.002
Brugia malayi hypothetical protein 0.0121 0.0068 0.0266
Echinococcus granulosus neuropeptide receptor A26 0.0501 0.0338 0.1322
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1106 0.0767 0.3557
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0039
Giardia lamblia Cathepsin B precursor 0.3052 0.2148 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0119 0.0067 0.029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0697 0.0477 0.2204
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1106 0.0767 0.3557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0697 0.0477 0.2204
Loa Loa (eye worm) cathepsin B 0.3052 0.2148 0.8401
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3052 0.2148 0.3146
Echinococcus granulosus ubiquitin specific protease 41 0.0119 0.0067 0.0261
Brugia malayi cathepsin Z-like cysteine proteinase 0.0419 0.0279 0.1093
Giardia lamblia Cathepsin B precursor 0.0419 0.0279 0.1022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0008 0.0027
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Onchocerca volvulus 0.1106 0.0767 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0419 0.0279 0.1282
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0031 0.0005 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0044 0.0014 0.0053
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3629 0.2556 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0014 0.0053
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1106 0.0767 1
Echinococcus multilocularis neuropeptide receptor A26 0.0501 0.0338 0.1322
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0116 0.0521
Loa Loa (eye worm) hypothetical protein 0.0419 0.0279 0.1093
Wolbachia endosymbiont of Brugia malayi recombinase A 0.045 0.0301 0.2625
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0031 0.0005 0.0007
Onchocerca volvulus 0.0827 0.0569 0.7408
Loa Loa (eye worm) hypothetical protein 0.0121 0.0068 0.0266
Giardia lamblia Cathepsin L-like protease 0.0419 0.0279 0.1022
Giardia lamblia Cysteine protease 0.0419 0.0279 0.1022
Loa Loa (eye worm) hypothetical protein 0.0279 0.018 0.0703
Trypanosoma cruzi cysteine peptidase, putative 0.0279 0.018 0.0687
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0044 0.0014 0.0053
Trypanosoma cruzi cysteine peptidase, putative 0.1579 0.1102 0.4302
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0419 0.0279 0.0409
Loa Loa (eye worm) hypothetical protein 0.0279 0.018 0.0703
Echinococcus multilocularis microtubule associated protein 2 0.2271 0.1593 0.6232
Echinococcus multilocularis FTZ F1 alpha 0.0044 0.0014 0.0053
Trypanosoma cruzi cysteine protease, putative 0.0697 0.0477 0.1851
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0189 0.0116 0.0454
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0008 0.0032
Loa Loa (eye worm) MH2 domain-containing protein 0.0368 0.0243 0.0952
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0044 0.0014 0.0053
Entamoeba histolytica cysteine proteinase, putative 0.0827 0.0569 0.4292
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0697 0.0477 0.0699
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0028 0.0112
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0009 0.0035
Leishmania major cathepsin L-like protease 0.1106 0.0767 0.3557
Giardia lamblia Cathepsin L precursor 0.0419 0.0279 0.1022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Onchocerca volvulus Cathepsin F homolog 0.1106 0.0767 1
Brugia malayi cathepsin B-like cysteine proteinase 0.3629 0.2556 1
Loa Loa (eye worm) hypothetical protein 0.0419 0.0279 0.1093
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0697 0.0477 0.0699
Echinococcus multilocularis muscleblind protein 1 0.0148 0.0087 0.034
Loa Loa (eye worm) RNA binding protein 0.0065 0.0028 0.011
Trypanosoma brucei polo-like protein kinase 0.0189 0.0116 0.0521
Onchocerca volvulus 0.0044 0.0014 0.0119
Mycobacterium ulcerans aldehyde dehydrogenase 0.0321 0.021 0.1835
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0049 0.0072
Giardia lamblia Cathepsin L precursor 0.0419 0.0279 0.1022
Entamoeba histolytica cysteine proteinase, putative 0.0697 0.0477 0.3591
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0044 0.0014 0.0053
Giardia lamblia Hypothetical protein 0.0419 0.0279 0.1022
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0419 0.0279 0.1282
Mycobacterium ulcerans replicative DNA helicase DnaB 0.161 0.1125 1
Schistosoma mansoni cellular tumor antigen P53 0.0038 0.0009 0.0014
Echinococcus multilocularis cysteine protease 0.1106 0.0767 0.2999
Echinococcus granulosus cathepsin L 0.0697 0.0477 0.1866
Toxoplasma gondii cathepsin CPL 0.1106 0.0767 0.3546
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0116 0.0521
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0116 0.0521
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0008 0.0017
Onchocerca volvulus 0.1106 0.0767 1
Echinococcus granulosus cathepsin L 0.0419 0.0279 0.1093
Brugia malayi MH2 domain containing protein 0.0368 0.0243 0.0952
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0028 0.0042
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.001 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0044 0.0014 0.0053
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Mycobacterium ulcerans aldehyde dehydrogenase 0.0321 0.021 0.1835
Plasmodium falciparum plasmepsin III 0.0572 0.0388 0.4919
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0014 0.0055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0014 0.0055
Brugia malayi Papain family cysteine protease containing protein 0.0419 0.0279 0.1093
Brugia malayi Cathepsin L-like precursor 0.1106 0.0767 0.2999
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0279 0.018 0.0703
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0014 0.0021
Brugia malayi beta-lactamase family protein 0.0039 0.001 0.0039
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0419 0.0279 0.356
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3629 0.2556 0.3745
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.001 0.0021
Giardia lamblia Cathepsin L precursor 0.0419 0.0279 0.1022
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0028 0.0094
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0419 0.0279 0.356
Plasmodium falciparum plasmepsin II 0.0791 0.0544 0.7009
Giardia lamblia Cathepsin L-like protease 0.0419 0.0279 0.1022
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.0065 0.0254
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Leishmania major hypothetical protein, conserved 0.0055 0.0021 0.0077
Plasmodium vivax vivapain-1 0.0697 0.0477 0.6171
Entamoeba histolytica hypothetical protein 0.0419 0.0279 0.2089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0014 0.0055
Trypanosoma cruzi cruzipain precursor, putative 0.0279 0.018 0.0687
Plasmodium vivax unspecified product 0.0697 0.0477 0.6171
Chlamydia trachomatis replicative DNA helicase 0.161 0.1125 1
Onchocerca volvulus 0.1106 0.0767 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0094 0.0049 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Echinococcus multilocularis aminopeptidase N 0.0031 0.0005 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0044 0.0014 0.0053
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0021 0.0064
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Onchocerca volvulus Cathepsin L homolog 0.0419 0.0279 0.3605
Leishmania major cathepsin L-like protease 0.1106 0.0767 0.3557
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0189 0.0116 0.0521
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0657 0.0448 0.1753
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0419 0.0279 0.0409
Plasmodium vivax aspartyl protease, putative 0.0572 0.0388 0.4993
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Loa Loa (eye worm) hypothetical protein 0.0419 0.0279 0.1093
Loa Loa (eye worm) ctsf protein 0.1106 0.0767 0.2999
Loa Loa (eye worm) hypothetical protein 0.0572 0.0388 0.1517
Schistosoma mansoni inositol monophosphatase 0.0036 0.0008 0.0012
Onchocerca volvulus Protein ultraspiracle homolog 0.0044 0.0014 0.0119
Toxoplasma gondii aspartyl protease ASP3 0.0572 0.0388 0.1775
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.0065 0.0254
Entamoeba histolytica cysteine protease, putative 0.0419 0.0279 0.2089
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0044 0.0014 0.0053
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.161 0.1125 1
Trypanosoma cruzi cruzipain precursor, putative 0.1579 0.1102 0.4302
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0039
Giardia lamblia Cathepsin B precursor 0.0419 0.0279 0.1022
Trypanosoma cruzi cysteine proteinase, putative 0.0697 0.0477 0.1851
Echinococcus granulosus aminopeptidase N 0.0031 0.0005 0.0018
Loa Loa (eye worm) fibroinase 0.1106 0.0767 0.2999
Mycobacterium leprae Probable lipase LipE 0.0039 0.001 0.0014
Brugia malayi Cathepsin L-like precursor 0.0827 0.0569 0.2226
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0049 0.0191
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0116 0.0521
Trypanosoma cruzi cysteine peptidase, putative 0.0697 0.0477 0.1851
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0419 0.0279 0.1282
Schistosoma mansoni aldehyde dehydrogenase 0.0321 0.021 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Brugia malayi ecdysteroid receptor 0.0044 0.0014 0.0053
Echinococcus multilocularis muscleblind protein 0.0148 0.0087 0.034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.001 0.0025
Loa Loa (eye worm) beta-lactamase 0.0039 0.001 0.0039
Schistosoma mansoni aldehyde dehydrogenase 0.0321 0.021 0.0308
Brugia malayi nuclear receptor NHR-88 0.0044 0.0014 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Brugia malayi photoreceptor-specific nuclear receptor 0.0044 0.0014 0.0053
Plasmodium vivax SET domain protein, putative 0.0094 0.0049 0.0517
Plasmodium vivax vivapain-3 0.0697 0.0477 0.6171
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0008 0.0017
Giardia lamblia Cysteine protease 0.0419 0.0279 0.1022
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0791 0.0544 0.2504
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0321 0.021 0.0822
Brugia malayi TAR-binding protein 0.0065 0.0028 0.011
Trypanosoma cruzi major cysteine proteinase, putative 0.0892 0.0615 0.2392
Plasmodium falciparum cysteine proteinase falcipain 3 0.1106 0.0767 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0189 0.0116 0.0454
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0014 0.002
Giardia lamblia Cysteine protease 0.0419 0.0279 0.1022
Echinococcus multilocularis ubiquitin specific protease 41 0.0119 0.0067 0.0261
Echinococcus granulosus tar DNA binding protein 0.0065 0.0028 0.011
Trypanosoma cruzi cysteine proteinase, putative 0.0697 0.0477 0.1851
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.3052 0.2148 1
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0021 0.006
Brugia malayi Cathepsin L-like precursor 0.1106 0.0767 0.2999
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.0279 0.1282
Loa Loa (eye worm) hypothetical protein 0.0054 0.0021 0.008
Loa Loa (eye worm) hypothetical protein 0.0827 0.0569 0.2226
Echinococcus multilocularis cathepsin L 0.0697 0.0477 0.1866
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0028 0.0111
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Brugia malayi Cathepsin L-like precursor 0.1106 0.0767 0.2999
Trypanosoma cruzi DNA repair protein, putative 0.0138 0.008 0.0297
Trypanosoma cruzi cysteine peptidase, putative 0.1579 0.1102 0.4302
Entamoeba histolytica cysteine protease, putative 0.0419 0.0279 0.2089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Toxoplasma gondii aspartyl protease ASP1 0.0791 0.0544 0.2504
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0014 0.0055
Echinococcus multilocularis cathepsin b 0.3629 0.2556 1
Trypanosoma cruzi DNA repair protein, putative 0.0138 0.008 0.0297
Brugia malayi serine/threonine-protein kinase plk-2 0.0189 0.0116 0.0454
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1886 0.132 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0419 0.0279 0.1077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0697 0.0477 0.2204
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Onchocerca volvulus 0.0039 0.001 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Echinococcus granulosus cathepsin b 0.3629 0.2556 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0014 0.0021
Leishmania major cathepsin L-like protease 0.1579 0.1102 0.5123
Onchocerca volvulus 0.0039 0.001 0.007
Plasmodium vivax vivapain-2 0.1106 0.0767 1
Loa Loa (eye worm) aminopeptidase N 0.0031 0.0005 0.0018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0321 0.021 0.1835
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0119 0.0067 0.0243
Loa Loa (eye worm) hypothetical protein 0.0055 0.0021 0.0082
Entamoeba histolytica cysteine protease, putative 0.1106 0.0767 0.5794
Giardia lamblia Cathepsin B precursor 0.0419 0.0279 0.1022
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Brugia malayi Peptidase family M1 containing protein 0.0031 0.0005 0.0018
Loa Loa (eye worm) aspartyl protease 6 0.0572 0.0388 0.1517
Loa Loa (eye worm) hypothetical protein 0.1106 0.0767 0.2999
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0419 0.0279 0.0409
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0039
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0044 0.0014 0.002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0044 0.0014 0.0119
Loa Loa (eye worm) hypothetical protein 0.0791 0.0544 0.2127
Brugia malayi Cathepsin L-like precursor 0.1106 0.0767 0.2999
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0697 0.0477 0.2204
Trypanosoma brucei cysteine peptidase C (CPC) 0.3052 0.2148 1
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0116 0.0521
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1106 0.0767 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0008 0.0033
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0419 0.0279 0.2089
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0049 0.0192
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0119 0.0067 0.029
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0119 0.0067 0.0243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0044 0.0014 0.0053
Brugia malayi cathepsin Z-like cysteine proteinase 0.0419 0.0279 0.1093
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0697 0.0477 0.1851
Schistosoma mansoni coup transcription factor 0.0044 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0419 0.0279 0.1282
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Schistosoma mansoni hypothetical protein 0.0037 0.0008 0.0012
Trichomonas vaginalis set domain proteins, putative 0.0748 0.0513 0.2371
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0014 0.0055
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0039
Schistosoma mansoni retinoic acid receptor RXR 0.0044 0.0014 0.002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.001 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0827 0.0569 0.2635
Plasmodium vivax aspartyl proteinase, putative 0.0572 0.0388 0.4993
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.001 0.0005
Giardia lamblia Cathepsin B precursor 0.3052 0.2148 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0014 0.0021
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0028 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0014 0.0053
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3629 0.2556 0.3745
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0419 0.0279 0.1093
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0044 0.0014 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Giardia lamblia Cathepsin B precursor 0.0419 0.0279 0.1022
Plasmodium falciparum serine repeat antigen 7 0.0419 0.0279 0.3465
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1106 0.0767 0.2999
Onchocerca volvulus 0.1106 0.0767 1
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.001 0.0025
Entamoeba histolytica cysteine proteinase 2 0.0697 0.0477 0.3591
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Echinococcus granulosus cathepsin L cysteine protease 0.0697 0.0477 0.1866
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0044 0.0014 0.0053
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.001 0.0005
Plasmodium vivax plasmepsin IV, putative 0.0791 0.0544 0.7053
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0419 0.0279 0.1282
Echinococcus granulosus FTZ F1 alpha 0.0044 0.0014 0.0053
Toxoplasma gondii cathepsin B 0.3052 0.2148 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0008 0.0012
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.001 0.0039
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0044 0.0014 0.0053
Brugia malayi hypothetical protein 0.0031 0.0005 0.0018
Schistosoma mansoni cathepsin S (C01 family) 0.0419 0.0279 0.0409
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0791 0.0544 0.2127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0044 0.0014 0.0053
Loa Loa (eye worm) hypothetical protein 0.0094 0.0049 0.0192
Plasmodium falciparum serine repeat antigen 8 0.0419 0.0279 0.3465
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0014 0.0053
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0419 0.0279 0.3465
Plasmodium falciparum serine repeat antigen 4 0.0419 0.0279 0.3465
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0419 0.0279 0.1282
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0014 0.0053
Brugia malayi cathepsin F-like cysteine proteinase 0.0279 0.018 0.0703
Brugia malayi Steroid receptor seven-up type 2 0.0044 0.0014 0.0053
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0014 0.002
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0419 0.0279 0.356
Brugia malayi hypothetical protein 0.0572 0.0388 0.1517
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.0047 0.0182
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0028 0.0111
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Toxoplasma gondii preprocathepsin c precursor, putative 0.0419 0.0279 0.1268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0044 0.0014 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0044 0.0014 0.0053
Brugia malayi fibroinase precursor 0.0419 0.0279 0.1093
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0419 0.0279 0.1282
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0049 0.0072
Giardia lamblia Kinase, PLK 0.0189 0.0116 0.0238
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0028 0.0111
Echinococcus multilocularis cathepsin L 0.0419 0.0279 0.1093
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0067 0.029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0014 0.0053
Loa Loa (eye worm) cysteine protease 0.1106 0.0767 0.2999
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0419 0.0279 0.1282
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0039
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0119 0.0067 0.0472
Leishmania major cysteine peptidase A (CPA) 0.1106 0.0767 0.3557
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0827 0.0569 0.2226
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Schistosoma mansoni lipoxygenase 0.0081 0.004 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0419 0.0279 0.1282
Entamoeba histolytica cysteine protease, putative 0.0419 0.0279 0.2089
Brugia malayi Cathepsin L-like precursor 0.1106 0.0767 0.2999
Trypanosoma cruzi cysteine peptidase, putative 0.1579 0.1102 0.4302
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0028 0.0182
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0028 0.011
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0044 0.0014 0.0053
Brugia malayi cathepsin F-like cysteine proteinase 0.0419 0.0279 0.1093
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0791 0.0544 0.0797
Brugia malayi nuclear hormone receptor 0.0044 0.0014 0.0053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0014 0.0053
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0419 0.0279 0.3465
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0119 0.0067 0.0261
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0028 0.0111
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0028 0.0094
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0031 0.0005 0.0007
Echinococcus multilocularis cysteine protease 0.1106 0.0767 0.2999
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0014 0.002
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.001 0.0005
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0572 0.0388 0.1517
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.001 0.0025
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0419 0.0279 0.1022
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0921 0.0636 0.5636
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0119 0.0067 0.0261
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.001 0.0005
Schistosoma mansoni cathepsin B (C01 family) 0.0419 0.0279 0.0409
Loa Loa (eye worm) inositol-1 0.0036 0.0008 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0321 0.021 0.0205
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0017
Schistosoma mansoni microtubule-associated protein tau 0.2271 0.1593 0.2334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Treponema pallidum replicative DNA helicase (dnaB) 0.161 0.1125 0.8081
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0419 0.0279 0.2089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0014 0.0053
Onchocerca volvulus Serine\/threonine kinase homolog 0.0189 0.0116 0.1464
Loa Loa (eye worm) hypothetical protein 0.0121 0.0068 0.0266
Mycobacterium leprae Conserved hypothetical protein 0.4747 0.335 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0697 0.0477 0.6114
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.3052 0.2148 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0419 0.0279 0.1282
Toxoplasma gondii cathepsin CPC1 0.0419 0.0279 0.1268
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0044 0.0014 0.0053
Mycobacterium tuberculosis Conserved protein 0.0039 0.001 0.0005
Schistosoma mansoni Replicative DNA helicase 0.161 0.1125 0.1647
Echinococcus granulosus cathepsin L cysteine proteinase 0.1106 0.0767 0.2999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Echinococcus granulosus cathepsin b 0.3629 0.2556 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0119 0.0067 0.0098
Giardia lamblia Encystation-specific protease 0.0419 0.0279 0.1022
Echinococcus multilocularis cathepsin L cysteine protease 0.1106 0.0767 0.2999
Plasmodium falciparum plasmepsin IX 0.0572 0.0388 0.4919
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0014 0.0053
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.13 0.0905 0.3528
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0419 0.0279 0.0409
Schistosoma mansoni steroid hormone receptor ad4bp 0.0044 0.0014 0.002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0044 0.0014 0.0053
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.0116 0.017
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0419 0.0279 0.356
Plasmodium vivax unspecified product 0.0419 0.0279 0.356
Entamoeba histolytica cysteine proteinase, putative 0.1106 0.0767 0.5794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0419 0.0279 0.1282
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0014 0.002
Toxoplasma gondii aldehyde dehydrogenase 0.0321 0.021 0.0944
Loa Loa (eye worm) hypothetical protein 0.0148 0.0087 0.034
Giardia lamblia Cathepsin L precursor 0.0419 0.0279 0.1022
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0116 0.0521
Loa Loa (eye worm) hypothetical protein 0.0419 0.0279 0.1093
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0028 0.0112
Entamoeba histolytica cysteine proteinase, putative 0.0697 0.0477 0.3591
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0044 0.0014 0.002
Plasmodium falciparum plasmepsin VI 0.0791 0.0544 0.7009
Onchocerca volvulus Bile acid receptor homolog 0.0044 0.0014 0.0119
Plasmodium vivax aspartyl proteinase, putative 0.0791 0.0544 0.7053
Schistosoma mansoni cathepsin F (C01 family) 0.0827 0.0569 0.0834
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0419 0.0279 0.356
Schistosoma mansoni lipoxygenase 0.0117 0.0065 0.0095
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Brugia malayi Cathepsin L-like precursor 0.1106 0.0767 0.2999
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1106 0.0767 0.2999
Brugia malayi Pre-SET motif family protein 0.0094 0.0049 0.0192
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0419 0.0279 0.0409
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0119 0.0067 0.029
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0094 0.0049 0.0192
Plasmodium falciparum plasmepsin V 0.0572 0.0388 0.4919
Plasmodium falciparum serine repeat antigen 2 0.0419 0.0279 0.3465
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0279 0.018 0.0703
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0009 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1579 0.1102 0.5123
Brugia malayi Papain family cysteine protease containing protein 0.0419 0.0279 0.1093
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0044 0.0014 0.002
Onchocerca volvulus Cathepsin L homolog 0.1106 0.0767 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.001 0.0005
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0119 0.0067 0.0098
Plasmodium falciparum plasmepsin VIII, putative 0.0572 0.0388 0.4919
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0419 0.0279 0.1093
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.0116 0.0521
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0017
Entamoeba histolytica cysteine proteinase, putative 0.0697 0.0477 0.3591
Giardia lamblia Cathepsin B precursor 0.0419 0.0279 0.1022
Plasmodium falciparum serine repeat antigen 9 0.0419 0.0279 0.3465
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.045 0.0301 0.0884
Brugia malayi beta-lactamase family protein 0.0039 0.001 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Onchocerca volvulus Huntingtin homolog 0.0121 0.0068 0.0833
Brugia malayi steroid hormone receptor 0.0044 0.0014 0.0053
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0021 0.008
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0021 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0419 0.0279 0.1282
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0044 0.0014 0.0053
Brugia malayi cathepsin L-like precursor 0.0827 0.0569 0.2226
Mycobacterium ulcerans lipase LipD 0.0039 0.001 0.0048
Brugia malayi Muscleblind-like protein 0.0148 0.0087 0.034
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0419 0.0279 0.356
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0189 0.0116 0.0454
Brugia malayi cathepsin L-like cysteine proteinase 0.0419 0.0279 0.1093
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1106 0.0767 0.3557
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0791 0.0544 0.2127
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0053
Giardia lamblia Cathepsin L precursor 0.0419 0.0279 0.1022
Brugia malayi Inositol-1 0.0036 0.0008 0.0032
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0572 0.0388 0.1775
Onchocerca volvulus 0.0572 0.0388 0.5028
Brugia malayi hypothetical protein 0.0035 0.0007 0.0028
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.0116 0.0437
Brugia malayi Pre-SET motif family protein 0.0657 0.0448 0.1753
Trypanosoma cruzi cysteine peptidase, putative 0.1106 0.0767 0.2987
Leishmania major cathepsin L-like protease 0.1106 0.0767 0.3557
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0419 0.0279 0.1093
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0419 0.0279 0.0409
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0021 0.008
Brugia malayi Papain family cysteine protease containing protein 0.1106 0.0767 0.2999
Loa Loa (eye worm) hypothetical protein 0.0119 0.0067 0.0261
Trichomonas vaginalis esterase, putative 0.0039 0.001 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0049 0.0205
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3629 0.2556 0.3745
Brugia malayi Cathepsin L-like precursor 0.0279 0.018 0.0703
Onchocerca volvulus 0.1106 0.0767 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0044 0.0014 0.0053
Onchocerca volvulus 0.0094 0.0049 0.0584
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0419 0.0279 0.1282
Schistosoma mansoni cathepsin F (C01 family) 0.1106 0.0767 0.1123
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0021 0.0146
Giardia lamblia Hypothetical protein 0.0419 0.0279 0.1022
Brugia malayi Papain family cysteine protease containing protein 0.0697 0.0477 0.1866
Loa Loa (eye worm) hypothetical protein 0.0419 0.0279 0.1093
Giardia lamblia Cathepsin L precursor 0.0419 0.0279 0.1022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0014 0.0053
Echinococcus granulosus ecdysone induced protein 78C 0.0044 0.0014 0.0053
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0419 0.0279 0.1022
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Mycobacterium ulcerans recombinase A 0.045 0.0301 0.2649
Plasmodium vivax vivapain-2 0.1106 0.0767 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Schistosoma mansoni cathepsin F (C01 family) 0.1106 0.0767 0.1123
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.161 0.1125 0.3346
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.001 0.0039
Schistosoma mansoni cathepsin D (A01 family) 0.1352 0.0942 0.1379
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1106 0.0767 0.3557
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3052 0.2148 0.8398
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Loa Loa (eye worm) hypothetical protein 0.0038 0.0009 0.0037
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0921 0.0636 0.0631
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0044 0.0014 0.0053
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0014
Brugia malayi hypothetical protein 0.0055 0.0021 0.0082
Onchocerca volvulus 0.1106 0.0767 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.001 0.0025
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0028 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0419 0.0279 0.1282
Giardia lamblia Fructose-bisphosphate aldolase 0.1886 0.132 0.6024
Onchocerca volvulus 0.0572 0.0388 0.5028
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0021 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0044 0.0014 0.0053
Plasmodium falciparum serine repeat antigen 3 0.0419 0.0279 0.3465
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0419 0.0279 0.356
Schistosoma mansoni memapsin-2 (A01 family) 0.9647 0.6826 1
Toxoplasma gondii ABC1 family protein 0.0039 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0572 0.0388 0.1517
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 1.296 0.9177 0.9176
Entamoeba histolytica serine/threonine protein kinase, putative 0.0189 0.0116 0.0848
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0008 0.0017
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0791 0.0544 0.2516
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Loa Loa (eye worm) steroid hormone receptor 0.0044 0.0014 0.0053
Plasmodium falciparum plasmepsin VII 0.0572 0.0388 0.4919
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.001 0.0048
Plasmodium vivax aspartyl protease, putative 0.0572 0.0388 0.4993
Brugia malayi Cathepsin L-like cysteine proteinase 0.0827 0.0569 0.2226
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0008 0.0032
Schistosoma mansoni cathepsin s 0.0279 0.018 0.0263
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0028 0.011
Echinococcus multilocularis cathepsin L cysteine protease 0.1106 0.0767 0.2999
Loa Loa (eye worm) twinkle helicase 0.046 0.0309 0.1207
Plasmodium vivax serine-repeat antigen (SERA) 0.0419 0.0279 0.356
Brugia malayi RNA binding protein 0.0065 0.0028 0.011
Echinococcus granulosus cathepsin l1 0.0827 0.0569 0.2226
Echinococcus multilocularis thyroid hormone receptor alpha 0.0044 0.0014 0.0053
Onchocerca volvulus 0.0419 0.0279 0.3605
Plasmodium vivax aspartyl protease, putative 0.0572 0.0388 0.4993
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0028 0.0041
Echinococcus granulosus cathepsin l cysteine peptidase 0.1106 0.0767 0.2999
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0049 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0014 0.0053
Toxoplasma gondii cathepsin CPC2 0.0419 0.0279 0.1268
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0014 0.0055
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0419 0.0279 0.1022
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1886 0.132 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0044 0.0014 0.002
Giardia lamblia Cathepsin B precursor 0.3052 0.2148 1
Entamoeba histolytica cysteine protease, putative 0.0419 0.0279 0.2089
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0119 0.0067 0.029
Plasmodium falciparum plasmepsin IV 0.0791 0.0544 0.7009
Echinococcus granulosus cysteine protease 0.0697 0.0477 0.1866
Echinococcus multilocularis neuropeptide s receptor 0.0501 0.0338 0.1322
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0419 0.0279 0.0409
Plasmodium falciparum serine repeat antigen 1 0.0419 0.0279 0.3465
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0021 0.008
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0138 0.008 0.0354
Brugia malayi Papain family cysteine protease containing protein 0.0697 0.0477 0.1866
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1106 0.0767 0.2999
Giardia lamblia Cysteine protease 0.0419 0.0279 0.1022
Brugia malayi hypothetical protein 0.0572 0.0388 0.1517
Entamoeba histolytica cysteine proteinase, putative 0.1106 0.0767 0.5794
Loa Loa (eye worm) hypothetical protein 0.0419 0.0279 0.1093
Onchocerca volvulus 0.0748 0.0513 0.6665
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0031 0.0005 0.0018
Leishmania major cathepsin L-like protease 0.1579 0.1102 0.5123
Brugia malayi Papain family cysteine protease containing protein 0.0419 0.0279 0.1093
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0119 0.0067 0.0261
Loa Loa (eye worm) hypothetical protein 0.0279 0.018 0.0703
Plasmodium vivax plasmepsin V, putative 0.0572 0.0388 0.4993
Mycobacterium leprae conserved hypothetical protein 0.0039 0.001 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0028 0.0041
Plasmodium falciparum plasmepsin X 0.0572 0.0388 0.4919
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0419 0.0279 0.1093
Echinococcus granulosus neuropeptide s receptor 0.0501 0.0338 0.1322
Schistosoma mansoni cathepsin D (A01 family) 0.1352 0.0942 0.1379
Loa Loa (eye worm) hypothetical protein 0.3629 0.2556 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0419 0.0279 0.3465
Entamoeba histolytica cysteine protease, putative 0.0419 0.0279 0.2089
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.001 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0419 0.0279 0.1282
Mycobacterium ulcerans hypothetical protein 0.0039 0.001 0.0048
Echinococcus granulosus cathepsin l1 0.1106 0.0767 0.2999
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0321 0.021 0.0959
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.001 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.001 0.0015
Onchocerca volvulus Huntingtin homolog 0.0121 0.0068 0.0833
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.0279 0.1282
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0044 0.0014 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1886 0.132 0.6139
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0039
Brugia malayi Cathepsin L-like precursor 0.0827 0.0569 0.2226
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0014 0.0053
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.0116 0.0437
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0572 0.0388 0.0568
Echinococcus multilocularis cathepsin b 0.3629 0.2556 1
Onchocerca volvulus 0.1106 0.0767 1
Loa Loa (eye worm) transcription factor SMAD2 0.0368 0.0243 0.0952
Leishmania major cathepsin L-like protease 0.1579 0.1102 0.5123
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0921 0.0636 0.1885
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0008 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.001 0.0021
Plasmodium vivax serine-repeat antigen (SERA) 0.0419 0.0279 0.356
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.001 0.0039
Onchocerca volvulus Cathepsin L homolog 0.1106 0.0767 1
Plasmodium falciparum serine repeat antigen 5 0.0419 0.0279 0.3465
Brugia malayi aspartic protease BmAsp-1, identical 0.0572 0.0388 0.1517
Entamoeba histolytica cysteine protease, putative 0.0697 0.0477 0.3591
Entamoeba histolytica cysteine proteinase 1, putative 0.0697 0.0477 0.3591
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0791 0.0544 0.2127
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0419 0.0279 0.356
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0419 0.0279 0.356
Leishmania major hypothetical protein, conserved 0.0039 0.001 0.0025
Brugia malayi aspartic protease BmAsp-2, identical 0.0572 0.0388 0.1517
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0811 0.0558 0.2181
Onchocerca volvulus 0.0039 0.001 0.007
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0419 0.0279 0.1022
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0419 0.0279 0.0409
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0044 0.0014 0.0053
Onchocerca volvulus 0.0038 0.0009 0.0064
Schistosoma mansoni RAR-like nuclear receptor 0.0044 0.0014 0.002
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.0159 0.0154
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.3629 0.2556 0.3745

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 6 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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