Detailed information for compound 105704

Basic information

Technical information
  • TDR Targets ID: 105704
  • Name: [(2'S,6S,9aR)-2'-[[tert-butyl(diphenyl)silyl] oxymethyl]spiro[1,2,3,4,7,8,9,9a-octahydroqui nolizine-6,1'-cyclopentane]-3-yl]methanol
  • MW: 491.78 | Formula: C31H45NO2Si
  • H donors: 1 H acceptors: 1 LogP: 7.45 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1CC[C@@H]2N(C1)[C@@]1(CCC[C@@H]1CO[Si](C(C)(C)C)(c1ccccc1)c1ccccc1)CCC2
  • InChi: 1S/C31H45NO2Si/c1-30(2,3)35(28-14-6-4-7-15-28,29-16-8-5-9-17-29)34-24-26-12-10-20-31(26)21-11-13-27-19-18-25(23-33)22-32(27)31/h4-9,14-17,25-27,33H,10-13,18-24H2,1-3H3/t25?,26-,27-,31+/m1/s1
  • InChiKey: BBQDINFGZWRDGU-RVXAHLEHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2'S,6S,9aR)-2'-[[tert-butyl(diphenyl)silyl]oxymethyl]-3-spiro[1,2,3,4,7,8,9,9a-octahydroquinolizine-6,1'-cyclopentane]yl]methanol
  • [(1S,2S,9'aR)-2-[[tert-butyl(diphenyl)silyl]oxymethyl]spiro[cyclopentane-1,6'-quinolizidine]-3'-yl]methanol
  • [(2'S,6S,9aR)-2'-[(tert-butyl-di(phenyl)silyl)oxymethyl]spiro[1,2,3,4,7,8,9,9a-octahydroquinolizine-6,1'-cyclopentane]-3-yl]methanol
  • [(2'S,6S,9aR)-2'-[(tert-butyl-di(phenyl)silyl)oxymethyl]-3-spiro[1,2,3,4,7,8,9,9a-octahydroquinolizine-6,1'-cyclopentane]yl]methanol
  • [(1S,2S,9'aR)-2-[(tert-butyl-di(phenyl)silyl)oxymethyl]spiro[cyclopentane-1,6'-quinolizidine]-3'-yl]methanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0146 0.0038
Toxoplasma gondii DNA topoisomerase 2, putative 0.0027 0.0146 0.0652
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0604 0.0697
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0122 0.0116
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0084 0.0494
Trypanosoma brucei heat shock protein, putative 0.0027 0.0146 0.0252
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0224 0.0249
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0355 0.3781 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.061 0.0604
Schistosoma mansoni hypothetical protein 0.0034 0.0219 0.0243
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0203 0.0232
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.1026 0.2942
Trypanosoma brucei heat shock protein, putative 0.0027 0.0146 0.0252
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0027 0.0146 0.0924
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0172 0.1748 0.3286
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0146 0.0252
Echinococcus granulosus geminin 0.0337 0.3588 0.4224
Mycobacterium tuberculosis Probable two component sensor kinase 0.0027 0.0146 0.0924
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0122 0.0116
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0122 0.0205
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0146 0.0252
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0146 0.0252
Echinococcus granulosus tumor protein p63 0.0341 0.3633 0.4276
Schistosoma mansoni kinase 0.0054 0.0444 0.0509
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0122 0.0136
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.061 0.3843
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0122 0.0205
Loa Loa (eye worm) hypothetical protein 0.003 0.0175 0.0264
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0146 0.3918
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0027 0.0146 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0122 0.0205
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.2739 0.867
Echinococcus multilocularis 0.0022 0.0084 0.0078
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.105 0.1231
Mycobacterium ulcerans putative regultory protein 0.0027 0.0146 0.0452
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0122 0.0136
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0172 0.1748 0.3286
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0561 0.0555
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0146 0.0252
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.1032 0.193
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0122 0.0128
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0219 0.0213
Loa Loa (eye worm) hypothetical protein 0.0046 0.0353 0.0532
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.1452 1
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Toxoplasma gondii heat shock protein HSP90 0.0027 0.0146 0.0652
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0084 0.0494
Entamoeba histolytica hypothetical protein 0.0109 0.105 0.2487
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.2739 0.867
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.061 0.113
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0084 0.0494
Mycobacterium ulcerans DNA gyrase subunit B 0.0027 0.0146 0.0452
Echinococcus multilocularis lamin 0.003 0.0181 0.0175
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0084 0.0494
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0172 0.1748 0.8513
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0122 0.0128
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.061 0.4147
Brugia malayi TAR-binding protein 0.0065 0.0561 0.1037
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0039 0.0273 0.7648
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.3137 1
Plasmodium vivax DNA topoisomerase II, putative 0.0027 0.0146 0.3918
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0122 0.0205
Mycobacterium ulcerans two component regulator - sensor kinase 0.0027 0.0146 0.0452
Trichomonas vaginalis set domain proteins, putative 0.0268 0.2817 0.8929
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0013 0.0007
Trypanosoma brucei polo-like protein kinase 0.0107 0.1026 0.1919
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0122 0.0128
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0084 0.0135
Trypanosoma brucei heat shock protein, putative 0.0027 0.0146 0.0252
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0146 0.0252
Brugia malayi intermediate filament protein 0.003 0.0181 0.0317
Entamoeba histolytica hypothetical protein 0.0109 0.105 0.2487
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.1026 0.2942
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Trypanosoma brucei heat shock protein, putative 0.0027 0.0146 0.0252
Mycobacterium tuberculosis Conserved protein 0.0027 0.0146 0.0924
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0101 0.0964 0.2249
Entamoeba histolytica hypothetical protein 0.0109 0.105 0.2487
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0084 0.0494
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.1026 0.2942
Brugia malayi Augmenter of liver regeneration 0.0039 0.0273 0.0491
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1744 0.534
Plasmodium falciparum basic transcription factor 3b, putative 0.0039 0.0281 0.7891
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0122 0.0205
Onchocerca volvulus Phospholipase A2 homolog 0.0274 0.288 0.4238
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.061 0.0704
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3137 1
Onchocerca volvulus 0.0029 0.0165 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0281 0.0451
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0561 0.0846
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0146 0.0252
Brugia malayi hypothetical protein 0.0046 0.0353 0.0643
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0207 0.214 0.2135
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.1026 0.1919
Loa Loa (eye worm) hypothetical protein 0.0034 0.0219 0.0331
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0398 0.0454
Trypanosoma brucei heat shock protein, putative 0.0027 0.0146 0.0252
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0027 0.0146 0.0924
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0561 0.0646
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0084 0.0494
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.0281 0.0507
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0146 0.0038
Mycobacterium ulcerans two component sensor kinase MprB 0.0027 0.0146 0.0452
Loa Loa (eye worm) hypothetical protein 0.0027 0.014 0.0211
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0027 0.0146 0.0452
Leishmania major cytochrome p450-like protein 0.0022 0.0084 0.0135
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0122 0.0116
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0084 0.0135
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0224 0.0249
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1744 0.534
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0224 0.0218
Brugia malayi Endoplasmin precursor 0.0027 0.0146 0.0252
Mycobacterium tuberculosis Possible two component sensor kinase 0.0027 0.0146 0.0924
Echinococcus multilocularis cpg binding protein 0.0031 0.0184 0.0178
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0122 0.0136
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0561 0.0646
Loa Loa (eye worm) hypothetical protein 0.0025 0.0122 0.0184
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0084 0.0135
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0491 0.5293 0.6234
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0146 0.0252
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0604 0.0705
Loa Loa (eye worm) RNA binding protein 0.0065 0.0561 0.0846
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1744 0.534
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0122 0.0128
Onchocerca volvulus 0.003 0.0181 0.0091
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.2441 0.3682
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0429 0.0945
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0491 0.5293 0.529
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0122 0.0116
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.0221
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0013 0.0007
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0027 0.0146 0.0252
Trypanosoma brucei heat shock protein, putative 0.0027 0.0146 0.0252
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0604 0.3796
Trypanosoma brucei heat shock protein, putative 0.0027 0.0146 0.0252
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.0521 0.0786
Echinococcus granulosus dnaJ subfamily B 0.0413 0.443 0.5217
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.105 0.1224
Entamoeba histolytica hypothetical protein 0.0109 0.105 0.2487
Schistosoma mansoni lamin 0.003 0.0181 0.0198
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0027 0.0146 0.0452
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0027 0.0146 0.0038
Leishmania major basic transcription factor 3a, putative 0.0039 0.0281 0.0507
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0656 0.1217
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3137 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0513 0.0774
Onchocerca volvulus 0.003 0.0181 0.0091
Echinococcus granulosus lipoxygenase domain containing protein 0.0046 0.0353 0.0409
Brugia malayi beta-NAC-like protein 0.0039 0.0281 0.0507
Toxoplasma gondii heat shock protein 90, putative 0.0027 0.0146 0.0652
Schistosoma mansoni transcription factor btf3 0.0039 0.0281 0.0316
Brugia malayi Cytochrome P450 family protein 0.0022 0.0084 0.0135
Onchocerca volvulus Phospholipase A2 homolog 0.0611 0.6629 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0122 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0122 0.0184
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0146 0.0252
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0084 0.0494
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0039 0.0273 0.7648
Brugia malayi hypothetical protein 0.0109 0.105 0.1964
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0122 0.0128
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0107 0.1026 0.1919
Loa Loa (eye worm) hypothetical protein 0.0025 0.0122 0.0184
Plasmodium falciparum LCCL domain-containing protein 0.0046 0.0353 1
Schistosoma mansoni cpg binding protein 0.0031 0.0184 0.0201
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Entamoeba histolytica transcription factor BTF3, putative 0.0039 0.0281 0.0371
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0013 0.002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0122 0.0205
Brugia malayi cytochrome P450 0.0022 0.0084 0.0135
Trypanosoma brucei Heat shock protein 83, putative 0.0027 0.0146 0.0252
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0084 0.0494
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.3137 0.8229
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0027 0.0146 0.0452
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0122 0.0128
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0024 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.1026 0.1195
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0039 0.0273 0.0491
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3137 1
Echinococcus granulosus GPCR family 2 0.0034 0.0219 0.0251
Plasmodium falciparum DNA gyrase subunit B 0.0027 0.0146 0.3918
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.1026 0.2942
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0122 0.0205
Schistosoma mansoni hypothetical protein 0.0034 0.0219 0.0243
Brugia malayi Cytochrome P450 family protein 0.0048 0.0381 0.0696
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0561 0.0646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0122 0.0184
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0604 0.2896
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0467 0.2226
Loa Loa (eye worm) hypothetical protein 0.0025 0.0122 0.0184
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0224 0.0249
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0084 0.0494
Schistosoma mansoni hypothetical protein 0.0046 0.0353 0.04
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1846 0.5682
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.1452 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0027 0.0146 0.0924
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0039 0.0273 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0122 0.0205
Plasmodium falciparum endoplasmin, putative 0.0027 0.0146 0.3918
Trypanosoma brucei heat shock protein, putative 0.0027 0.0146 0.0252
Loa Loa (eye worm) hypothetical protein 0.0025 0.0122 0.0184
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0013 0.0007
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.443 0.4427
Trypanosoma brucei developmentally regulated phosphoprotein 0.0491 0.5293 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0165 0.0288
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0027 0.0146 0.0452
Brugia malayi ecdysteroid receptor 0.0025 0.0122 0.0205
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0122 0.0116
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0122 0.0128
Echinococcus granulosus heat shock protein 0.0027 0.0146 0.0165
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Schistosoma mansoni heat shock protein 0.0027 0.0146 0.0157
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.2739 0.867
Loa Loa (eye worm) cytochrome P450 0.0022 0.0084 0.0127
Trypanosoma cruzi Heat shock protein 83, putative 0.0027 0.0146 0.0252
Brugia malayi follicle stimulating hormone receptor 0.0234 0.2441 0.4598
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0219 0.039
Schistosoma mansoni DNA topoisomerase II 0.0027 0.0146 0.0157
Schistosoma mansoni cytochrome P450 0.0022 0.0084 0.0084
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0224 0.0257
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0084 0.0349
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.1032 0.1557
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0233 0.2432 0.286
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0027 0.0146 0.5
Echinococcus multilocularis geminin 0.0337 0.3588 0.3584
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0219 0.0251
Schistosoma mansoni hypothetical protein 0.0022 0.0084 0.0084
Onchocerca volvulus 0.0046 0.0353 0.0355
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0122 0.0116
Loa Loa (eye worm) intermediate filament protein 0.003 0.0181 0.0273
Loa Loa (eye worm) hypothetical protein 0.0034 0.0224 0.0338
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Plasmodium falciparum DNA topoisomerase 2 0.0027 0.0146 0.3918
Schistosoma mansoni lipoxygenase 0.0233 0.2432 0.2854
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.0281 0.7891
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0224 0.1034
Brugia malayi steroid hormone receptor 0.0025 0.0122 0.0205
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0561 0.0646
Loa Loa (eye worm) hypothetical protein 0.0025 0.0122 0.0184
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0224 0.0218
Schistosoma mansoni pyruvate dehydrogenase 0.0464 0.4989 0.5873
Loa Loa (eye worm) hypothetical protein 0.0611 0.6629 1
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0172 0.1748 0.3286
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.2739 0.867
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0084 0.0494
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0261 0.2739 0.5164
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0219 0.039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3137 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0107 0.1026 0.139
Schistosoma mansoni endoplasmin 0.0027 0.0146 0.0157
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1846 0.5682
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0039 0.0273 0.0491
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0122 0.0184
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0604 0.3796
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0013 0.0007
Schistosoma mansoni intermediate filament proteins 0.003 0.0181 0.0198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0122 0.0184
Loa Loa (eye worm) endoplasmin 0.0027 0.0146 0.0221
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0146 0.0652
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0122 0.0205
Echinococcus granulosus cpg binding protein 0.0031 0.0184 0.0209
Echinococcus granulosus intermediate filament protein 0.003 0.0181 0.0206
Echinococcus granulosus lamin dm0 0.003 0.0181 0.0206
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0084 0.0494
Toxoplasma gondii NAC domain-containing protein 0.0039 0.0281 0.1313
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0027 0.0146 0.0165
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.1026 0.2942
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.3137 0.8229
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0122 0.0136
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0207 0.214 0.2516
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.1026 0.2942
Entamoeba histolytica serine/threonine protein kinase, putative 0.0107 0.1026 0.2421
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0381 0.0575
Schistosoma mansoni pyruvate dehydrogenase 0.0464 0.4989 0.5873
Schistosoma mansoni heat shock protein 0.0027 0.0146 0.0157
Brugia malayi RNA binding protein 0.0065 0.0561 0.1037
Schistosoma mansoni hypothetical protein 0.0034 0.0219 0.0243
Echinococcus granulosus lamin 0.003 0.0181 0.0206
Schistosoma mansoni polycystin 1-related 0.0046 0.0353 0.04
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0027 0.0146 0.3918
Brugia malayi nuclear receptor NHR-88 0.0025 0.0122 0.0205
Loa Loa (eye worm) CYP4Cod1 0.0048 0.0381 0.0575
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0235 0.2457 0.3706
Echinococcus multilocularis lipoxygenase domain containing protein 0.0046 0.0353 0.0347
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0146 0.0252
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0146 0.0252
Loa Loa (eye worm) hypothetical protein 0.028 0.2953 0.4454
Toxoplasma gondii Erv1 / Alr family protein 0.0039 0.0273 0.1273
Chlamydia trachomatis DNA gyrase subunit B 0.0027 0.0146 0.5
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0281 0.0507
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0122 0.0184
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3137 1
Onchocerca volvulus 0.0046 0.0353 0.0355
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.3137 0.8229
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0604 0.3796
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0281 0.0451
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0122 0.0205
Plasmodium vivax SET domain protein, putative 0.0034 0.0224 0.6212
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0027 0.0146 0.0252
Loa Loa (eye worm) hypothetical protein 0.0025 0.0122 0.0184
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0107 0.1026 0.1203
Giardia lamblia Kinase, PLK 0.0107 0.1026 0.2421
Brugia malayi hypothetical protein 0.0046 0.0353 0.0643
Echinococcus multilocularis heat shock protein 0.0027 0.0146 0.014
Chlamydia trachomatis DNA gyrase subunit B 0.0027 0.0146 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0122 0.0116
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0122 0.0184
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0039 0.0273 0.0267
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.2739 0.867
Echinococcus granulosus RUN 0.0046 0.0353 0.0409
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0027 0.0146 0.0924
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0084 0.0494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0122 0.0184
Echinococcus granulosus tar DNA binding protein 0.0065 0.0561 0.0654
Leishmania major DNA topoisomerase ii 0.0027 0.0146 0.0252
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0122 0.0136
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0381 0.0575
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0084 0.0494
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0122 0.0184
Schistosoma mansoni endoplasmin 0.0027 0.0146 0.0157
Schistosoma mansoni hypothetical protein 0.0034 0.0219 0.0243
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0027 0.0146 0.0452
Loa Loa (eye worm) hepatopoietin HPO2 0.0039 0.0273 0.0412
Schistosoma mansoni hypothetical protein 0.0413 0.443 0.5213
Echinococcus multilocularis tumor protein p63 0.0341 0.3633 0.3629
Loa Loa (eye worm) doublecortin family protein 0.0046 0.0353 0.0532
Echinococcus granulosus transcription factor btf3 0.0039 0.0281 0.0324
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0027 0.0146 0.0924
Echinococcus multilocularis microtubule associated protein 2 0.0779 0.8487 0.8486
Brugia malayi Pre-SET motif family protein 0.0235 0.2457 0.4629
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.0146 0.5
Brugia malayi Doublecortin family protein 0.0046 0.0353 0.0643
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.1452 1
Onchocerca volvulus 0.005 0.0398 0.0424
Toxoplasma gondii Erv1 / Alr family protein 0.0039 0.0273 0.1273
Brugia malayi kinase, mitochondrial precursor 0.0491 0.5293 1
Leishmania major mitochondrial DNA topoisomerase II 0.0027 0.0146 0.0252
Brugia malayi serine/threonine-protein kinase plk-2 0.0107 0.1026 0.1919
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0027 0.0146 0.0924
Schistosoma mansoni loxhd1 0.0046 0.0353 0.04
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0009
Entamoeba histolytica hypothetical protein 0.0039 0.0281 0.0371
Schistosoma mansoni lipoxygenase 0.0151 0.1515 0.1772
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.054 0.0622
Echinococcus multilocularis RUN 0.0046 0.0353 0.0347
Schistosoma mansoni coup transcription factor 0.0025 0.0122 0.0128
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0122 0.0128
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0491 0.5293 0.529
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0084 0.0494
Echinococcus granulosus Polycystic kidney disease protein 0.0046 0.0353 0.0409
Brugia malayi Probable DNA topoisomerase II 0.0027 0.0146 0.0252
Schistosoma mansoni rab6-interacting 0.0046 0.0353 0.04
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0027 0.0146 0.0924
Leishmania major hypothetical protein, conserved 0.0039 0.0273 0.0491
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0381 0.0696
Echinococcus granulosus heat shock protein 90 0.0027 0.0146 0.0165
Loa Loa (eye worm) TOPoisomerase family member 0.0027 0.0146 0.0221
Leishmania major cytochrome p450-like protein 0.0022 0.0084 0.0135
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0027 0.0146 0.0452
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0122 0.0205
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1744 0.534
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0027 0.0146 0.0924
Schistosoma mansoni hypothetical protein 0.0337 0.3588 0.4219
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0027 0.0146 0.0452
Schistosoma mansoni pyruvate dehydrogenase 0.0491 0.5293 0.623
Schistosoma mansoni rab6-interacting 0.0046 0.0353 0.04
Echinococcus multilocularis musashi 0.003 0.0181 0.0175
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0604 0.1118
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0027 0.0146 0.0924
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0027 0.0146 0.014
Brugia malayi Cytochrome P450 family protein 0.0061 0.0521 0.0962
Loa Loa (eye worm) hypothetical protein 0.005 0.0398 0.06
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.0122 0.0128
Entamoeba histolytica hypothetical protein 0.0101 0.0964 0.2249
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0429 0.0945
Brugia malayi Phospholipase A2 family protein 0.0274 0.288 0.5429
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0084 0.0494
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0561 0.0646
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0561 0.0846
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.061 0.0712
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0219 0.0331
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0604 0.0697
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0122 0.0136
Schistosoma mansoni cpg binding protein 0.0031 0.0184 0.0201
Schistosoma mansoni hypothetical protein 0.0073 0.0656 0.0758
Loa Loa (eye worm) ICD-1 protein 0.0039 0.0281 0.0424
Schistosoma mansoni microtubule-associated protein tau 0.0779 0.8487 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0107 0.1026 0.1021
Schistosoma mansoni hypothetical protein 0.0109 0.105 0.1224
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0181 0.0317
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1744 0.534
Echinococcus multilocularis Polycystic kidney disease protein 0.0046 0.0353 0.0347
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0027 0.0146 0.5
Loa Loa (eye worm) hypothetical protein 0.0073 0.0656 0.099
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.0221
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Echinococcus multilocularis lipoxygenase domain containing protein 0.0046 0.0353 0.0347
Onchocerca volvulus 0.0268 0.2817 0.4142
Brugia malayi heat shock protein 90 0.0027 0.0146 0.0252
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0107 0.1026 0.1548
Schistosoma mansoni lamin 0.003 0.0181 0.0198
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0084 0.0135
Giardia lamblia DNA repair protein RAD52 0.0355 0.3781 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0604 0.0598
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Plasmodium vivax endoplasmin, putative 0.0027 0.0146 0.3918
Plasmodium vivax heat shock protein 86, putative 0.0027 0.0146 0.3918
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0084 0.0092
Mycobacterium leprae Probable two component sensor kinase MprB 0.0027 0.0146 0.0452
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0122 0.0205
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.1744 0.2492
Leishmania major cytochrome p450-like protein 0.0048 0.0381 0.0696
Loa Loa (eye worm) hypothetical protein 0.0274 0.288 0.4344
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3137 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0122 0.0205
Onchocerca volvulus 0.0034 0.0224 0.0157
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0122 0.0136
Leishmania major developmentally regulated phosphoprotein-like protein 0.0491 0.5293 1
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0146 0.0252
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0281 0.0507
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0122 0.0128
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0013 0.0009
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0027 0.0146 0.0252
Loa Loa (eye worm) hypothetical protein 0.0025 0.0122 0.0184
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1744 0.534
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.1026 0.1919
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0561 0.1037
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0146 0.0252
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3137 1
Echinococcus multilocularis lamin dm0 0.003 0.0181 0.0175
Trypanosoma brucei cytochrome P450, putative 0.0048 0.0381 0.0696
Brugia malayi Pre-SET motif family protein 0.0034 0.0224 0.0399
Plasmodium falciparum heat shock protein 90 0.0027 0.0146 0.3918
Echinococcus multilocularis GPCR, family 2 0.0034 0.0219 0.0213
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0122 0.0116
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0027 0.0146 0.0452
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0084 0.0494
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0084 0.0135
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0199 0.2051 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.061 0.113
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0604 0.4102
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0122 0.0205
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0491 0.5293 1
Echinococcus granulosus microtubule associated protein 2 0.0779 0.8487 1
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0027 0.0146 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0281 0.0451
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0233 0.2432 0.2427
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0224 0.0249
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0122 0.0128
Loa Loa (eye worm) hypothetical protein 0.003 0.0181 0.0273
Loa Loa (eye worm) hypothetical protein 0.0491 0.5293 0.7984
Plasmodium vivax multidomain scavenger receptor, putative 0.0046 0.0353 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0084 0.0494
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0146 0.0252
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0122 0.0136
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0261 0.2739 0.4132
Echinococcus granulosus lipoxygenase domain containing protein 0.0046 0.0353 0.0409
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0039 0.0273 0.0491
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0146 0.0652
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0039 0.0273 0.0314
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.105 0.1045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.3137 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0048 0.0381 0.2167
Brugia malayi Cytochrome P450 family protein 0.0048 0.0381 0.0696
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.028 0.2953 0.5568
Loa Loa (eye worm) hypothetical protein 0.0025 0.0122 0.0184
Trypanosoma brucei DNA topoisomerase ii 0.0027 0.0146 0.0252
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.1026 0.2942
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0027 0.0146 0.0252
Mycobacterium leprae Probable two-component sensor kinase 0.0027 0.0146 0.0452
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0013 0.0007
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0084 0.0494
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0381 0.0696
Schistosoma mansoni cpg binding protein 0.0029 0.0165 0.0179
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0027 0.0146 0.0924
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0024 0.002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.0122 0.0136
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0181 0.0273
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0027 0.0146 0.0452
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0084 0.0494
Echinococcus multilocularis heat shock protein 90 0.0027 0.0146 0.014
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0122 0.0128
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1744 0.534
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0165 0.0249
Echinococcus multilocularis transcription factor btf3 0.0039 0.0281 0.0275
Plasmodium vivax DNA gyrase subunit B, putative 0.0027 0.0146 0.3918
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0084 0.0494
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0122 0.0205
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0122 0.0205
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0027 0.0146 0.0924
Loa Loa (eye worm) hypothetical protein 0.0046 0.0353 0.0532
Loa Loa (eye worm) heat shock protein 90 0.0027 0.0146 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.2739 0.867
Leishmania major hypothetical protein, conserved 0.0027 0.0146 0.0252
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.061 0.3843
Brugia malayi nuclear hormone receptor 0.0025 0.0122 0.0205
Leishmania major heat shock protein 83-1 0.0027 0.0146 0.0252
Schistosoma mansoni hypothetical protein 0.0337 0.3588 0.4219

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 32 uM Cytotoxicity towards the acute monocytic leukemia cell line (THP-1) ChEMBL. 12127506
IC50 (functional) = 32 uM Cytotoxicity towards the acute monocytic leukemia cell line (THP-1) ChEMBL. 12127506

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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