Detailed information for compound 1057203

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 228.207 | Formula: C11H8N4O2
  • H donors: 3 H acceptors: 3 LogP: -0.49 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1[nH]c2[nH][nH]c(=O)c2c(c1)c1ccccn1
  • InChi: 1S/C11H8N4O2/c16-8-5-6(7-3-1-2-4-12-7)9-10(13-8)14-15-11(9)17/h1-5H,(H3,13,14,15,16,17)
  • InChiKey: OYXBSIQUHBAZCB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens checkpoint kinase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Schistosoma japonicum Serine/threonine-protein kinase Chk1, putative Get druggable targets OG5_130454 All targets in OG5_130454
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase Get druggable targets OG5_130454 All targets in OG5_130454
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130454 All targets in OG5_130454
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0202 0.0795 0.2641
Onchocerca volvulus 0.0433 0.1785 1
Leishmania major cathepsin L-like protease 0.0066 0.0211 0.1737
Echinococcus multilocularis protein quaking 0.0061 0.0189 0.0189
Mycobacterium tuberculosis Possible penicillin-binding protein 0.053 0.2199 1
Loa Loa (eye worm) mbt repeat family protein 0.0057 0.0173 0.0576
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0057 0.0173 0.096
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0226 0.0895 0.0895
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0011 0.0037
Trichomonas vaginalis D-aminoacylase, putative 0.0083 0.0283 0.1117
Mycobacterium ulcerans hypothetical protein 0.0083 0.0283 0.2214
Brugia malayi hypothetical protein 0.0025 0.0034 0.0107
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0011 0.0011
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0611 0.0611
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0247 0.0821
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0065 0.0207 0.0207
Schistosoma mansoni lipoxygenase 0.0081 0.0276 0.0276
Treponema pallidum fructose-bisphosphate aldolase 0.0604 0.2519 0.5
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0101 0.0393
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0226 0.0898 0.2984
Schistosoma mansoni hypothetical protein 0.0072 0.0235 0.0235
Echinococcus granulosus jumonji domain containing 1A 0.0074 0.0247 0.0247
Echinococcus granulosus lamin dm0 0.0062 0.0194 0.0194
Echinococcus granulosus lamin 0.0062 0.0194 0.0194
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0226 0.0751
Leishmania major hypothetical protein, conserved 0.0083 0.0283 0.2341
Schistosoma mansoni zinc finger protein 0.0023 0.0026 0.0026
Brugia malayi hypothetical protein 0.0019 0.0011 0.003
Trichomonas vaginalis esterase, putative 0.0083 0.0283 0.1117
Loa Loa (eye worm) hypothetical protein 0.0155 0.0591 0.1964
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0065 0.0249
Schistosoma mansoni chromobox protein 0.008 0.0273 0.0273
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0072 0.0235 0.0235
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0011 0.0011
Schistosoma mansoni lamin 0.0062 0.0194 0.0194
Brugia malayi Doublecortin family protein 0.0019 0.0011 0.003
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0127 0.4437
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0295 0.1193 0.4752
Trichomonas vaginalis D-aminoacylase, putative 0.0083 0.0283 0.1117
Brugia malayi hypothetical protein 0.0433 0.1785 0.5932
Loa Loa (eye worm) glutaminase 2 0.0284 0.1146 0.381
Brugia malayi beta-lactamase family protein 0.0083 0.0283 0.0935
Loa Loa (eye worm) hypothetical protein 0.0062 0.0194 0.0645
Schistosoma mansoni jumonji/arid domain-containing protein 0.0281 0.1133 0.1133
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0072 0.024
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0011 0.0318
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0034 0.1142
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0002 0.0002
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0022 0.0811
Schistosoma mansoni hypothetical protein 0.0348 0.142 0.142
Leishmania major GTP-binding protein, putative 0.0022 0.0022 0.0165
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0025 0.0082
Onchocerca volvulus 0.0019 0.0011 0.005
Echinococcus multilocularis lysine specific demethylase 5A 0.0279 0.1124 0.1124
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.008 0.0307
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.0356 0.1178
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0101 0.4044
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0022 0.0165
Echinococcus granulosus protein quaking 0.0061 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0083 0.0283 0.0942
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0032 0.0117
Onchocerca volvulus 0.0083 0.0283 0.1577
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0018 0.0061
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.008 0.008
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0083 0.0283 0.2214
Trypanosoma brucei glucosidase, putative 0.0035 0.008 0.0486
Echinococcus multilocularis neuropeptide receptor A26 0.1064 0.4493 0.4493
Echinococcus multilocularis geminin 0.1264 0.535 0.535
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0065 0.0249
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.007 0.0227 0.0753
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0149 0.0494
Trichomonas vaginalis ran, putative 0.0022 0.0022 0.0079
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0011 0.0365
Brugia malayi Latrophilin receptor protein 2 0.0072 0.0235 0.0774
Echinococcus granulosus geminin 0.1264 0.535 0.535
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0074 0.0247 0.0821
Trypanosoma cruzi hypothetical protein, conserved 0.0083 0.0283 0.2341
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.008 0.275
Schistosoma mansoni lamin 0.0062 0.0194 0.0194
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.008 0.0307
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0127 0.0496
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0056 0.1907
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.008 0.0307
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0023 0.0023
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.008 0.0307
Echinococcus granulosus snurportin 1 0.0318 0.1293 0.1293
Loa Loa (eye worm) hypothetical protein 0.0046 0.0124 0.0412
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0129 0.0129
Echinococcus multilocularis importin subunit beta 1 0.003 0.0056 0.0056
Loa Loa (eye worm) MBCTL1 0.0065 0.0207 0.0689
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.008 0.0307
Brugia malayi hypothetical protein 0.0267 0.1074 0.3565
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0604 0.2519 1
Loa Loa (eye worm) runx1 0.0054 0.0161 0.0535
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0532 0.4313
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0226 0.0898 0.2978
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0011 0.0011
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0074 0.0247 0.8707
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.0356 0.1184
Schistosoma mansoni lipoxygenase 0.0116 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0057 0.0173 0.0576
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0604 0.2519 1
Echinococcus granulosus lysine specific demethylase 6a 0.0074 0.0247 0.0247
Schistosoma mansoni rab6-interacting 0.0019 0.0011 0.0011
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0604 0.2519 1
Brugia malayi hypothetical protein 0.008 0.0273 0.0899
Brugia malayi beta-lactamase family protein 0.0083 0.0283 0.0935
Echinococcus multilocularis peregrin 0.004 0.0098 0.0098
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0074 0.0247 0.8707
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0025 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0211 0.1598
Onchocerca volvulus 0.0083 0.0283 0.1577
Brugia malayi tumor suppressor. 0.0718 0.3008 1
Toxoplasma gondii hypothetical protein 0.0048 0.0134 0.4675
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0071 0.0235
Schistosoma mansoni hypothetical protein 0.002 0.0015 0.0015
Schistosoma mansoni ran 0.0022 0.0022 0.0022
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0349 0.1423 0.1423
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0034 0.1312
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0211 0.1598
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.0273 0.0273
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.0273 0.0273
Echinococcus granulosus cathepsin l1 0.0017 0.0002 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0247 0.0821
Schistosoma mansoni hypothetical protein 0.1264 0.535 0.535
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.008 0.0264
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0022 0.0706
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0035 0.008 0.0265
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0076 0.0255 0.0255
Schistosoma mansoni intermediate filament proteins 0.0062 0.0194 0.0194
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0196 0.0196
Leishmania major importin beta-1 subunit, putative 0.0024 0.0032 0.0245
Onchocerca volvulus 0.0092 0.0323 0.1799
Echinococcus multilocularis muscleblind protein 1 0.0151 0.0575 0.0575
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0074 0.0247 0.2038
Loa Loa (eye worm) hypothetical protein 0.0045 0.0121 0.0403
Echinococcus multilocularis zinc finger protein 0.0023 0.0026 0.0026
Brugia malayi beta-lactamase 0.0083 0.0283 0.0935
Echinococcus granulosus chromobox protein 1 0.008 0.0273 0.0273
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0022 0.0066
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.008 0.0644
Entamoeba histolytica hypothetical protein 0.008 0.0273 0.1074
Entamoeba histolytica hypothetical protein 0.008 0.0273 0.1074
Onchocerca volvulus 0.0083 0.0283 0.1577
Brugia malayi mbt repeat family protein 0.0057 0.0173 0.0569
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0015 0.005
Brugia malayi Importin beta-1 subunit 0.003 0.0056 0.0178
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0072 0.2494
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0433 0.1785 0.5935
Entamoeba histolytica hypothetical protein 0.008 0.0273 0.1074
Echinococcus multilocularis RUN 0.0019 0.0011 0.0011
Brugia malayi PHD-finger family protein 0.0028 0.0049 0.0155
Schistosoma mansoni importin beta-1 0.003 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0121 0.0473
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.008 0.0307
Schistosoma mansoni jumonji/arid domain-containing protein 0.0281 0.1133 0.1133
Trichomonas vaginalis penicillin-binding protein, putative 0.0083 0.0283 0.1117
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0022 0.0073
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.0553 0.0553
Onchocerca volvulus Huntingtin homolog 0.0267 0.1074 0.601
Mycobacterium ulcerans lipase LipD 0.0083 0.0283 0.2214
Loa Loa (eye worm) hypothetical protein 0.0044 0.0116 0.0385
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0114
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.0171
Leishmania major hypothetical protein, conserved 0.0074 0.0247 0.2038
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0072 0.2494
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.1203 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0611 0.2031
Brugia malayi Cytochrome P450 family protein 0.0051 0.0149 0.0487
Echinococcus multilocularis cysteine protease 0.0017 0.0002 0.0002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.06 0.1652
Echinococcus granulosus polycomb protein SCMH1 0.0057 0.0173 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0211 0.1598
Brugia malayi mbt repeat family protein 0.0057 0.0173 0.0569
Mycobacterium ulcerans beta-lactamase 0.0083 0.0283 0.2214
Mycobacterium ulcerans hypothetical protein 0.0157 0.06 0.492
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0065 0.0207 0.0207
Brugia malayi Heterochromatin protein 1 0.008 0.0273 0.0901
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0022 0.0706
Schistosoma mansoni myelin transcription factor 1 myt1 0.0065 0.0207 0.0207
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0107 0.0875
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0037
Brugia malayi RNA, U transporter 1 0.0085 0.0292 0.0963
Brugia malayi glutaminase DH11.1 0.0284 0.1146 0.3806
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0136 0.0532
Onchocerca volvulus 0.0173 0.0671 0.3752
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.008 0.0307
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0187 0.0729 0.4073
Loa Loa (eye worm) hypothetical protein 0.0061 0.0189 0.0629
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0002 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0062 0.0194 0.0645
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0283 1
Leishmania major hypothetical protein, conserved 0.0025 0.0034 0.0267
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.008 0.0257
Loa Loa (eye worm) tumor suppressor 0.0718 0.3008 1
Brugia malayi jmjC domain containing protein 0.0281 0.1133 0.376
Schistosoma mansoni jumonji domain containing protein 0.0326 0.1325 0.1325
Giardia lamblia Fructose-bisphosphate aldolase 0.0604 0.2519 1
Loa Loa (eye worm) beta-lactamase 0.0083 0.0283 0.0942
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0611 0.2025
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0532 0.4407
Brugia malayi N-terminal motif family protein 0.0187 0.0729 0.2416
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0318 0.1293 0.4298
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0211 0.1598
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0356 0.0356
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0136 0.0532
Onchocerca volvulus 0.0062 0.0194 0.1076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0356 0.0356
Brugia malayi chromobox protein homolog 3 0.0045 0.0121 0.0396
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0127 0.0127
Brugia malayi Cytochrome P450 family protein 0.0023 0.0025 0.0075
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0083 0.0283 0.0942
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0196 0.0196
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.0273 0.0907
Schistosoma mansoni bromodomain containing protein 0.0066 0.0211 0.0211
Brugia malayi Bromodomain containing protein 0.0041 0.0105 0.0343
Schistosoma mansoni phosphatidylserine receptor 0.0074 0.0247 0.0247
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0022 0.0165
Loa Loa (eye worm) hypothetical protein 0.0121 0.0448 0.1489
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0247 0.0821
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0611 0.0611
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0022 0.0022
Echinococcus multilocularis chromobox protein 1 0.008 0.0273 0.0273
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0011 0.0011
Echinococcus multilocularis histone acetyltransferase MYST2 0.0065 0.0207 0.0207
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.008 0.0307
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0034 0.0267
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0002 0.0007
Schistosoma mansoni hypothetical protein 0.008 0.0273 0.0273
Brugia malayi jmjC domain containing protein 0.0074 0.0247 0.0814
Echinococcus multilocularis lysine specific demethylase 6a 0.0074 0.0247 0.0247
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0147 0.1201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0211 0.1598
Brugia malayi PHD-finger family protein 0.0034 0.0072 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0211 0.1598
Schistosoma mansoni lozenge 0.0054 0.0161 0.0161
Echinococcus granulosus beta LACTamase domain containing family member 0.0083 0.0283 0.0283
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.1203 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0226 0.0895 0.0895
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.0202 0.0795 0.2636
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0211 0.1737
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.008 0.008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0072 0.0235 0.0235
Echinococcus granulosus histone acetyltransferase MYST2 0.0065 0.0207 0.0207
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0211 0.1737
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0083 0.0283 0.0935
Loa Loa (eye worm) hypothetical protein 0.0151 0.0575 0.1912
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0129 0.0129
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0604 0.2519 1
Echinococcus granulosus chromobox protein 1 0.008 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0267 0.1074 0.357
Giardia lamblia PHD finger protein 15 0.0034 0.0072 0.0201
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0002 0.0002
Echinococcus granulosus GPCR family 2 0.0072 0.0235 0.0235
Plasmodium falciparum JmjC domain-containing protein, putative 0.0074 0.0247 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0023 0.0023
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0065 0.0207 0.0682
Echinococcus multilocularis chromobox protein 1 0.008 0.0273 0.0273
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0211 0.1737
Schistosoma mansoni hypothetical protein 0.0034 0.0072 0.0072
Schistosoma mansoni chromobox protein 0.008 0.0273 0.0273
Brugia malayi hypothetical protein 0.0019 0.0011 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0356 0.0356
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0076 0.0255 0.0255
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0032 0.0245
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0211 0.1598
Loa Loa (eye worm) cysteine protease 0.0017 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0083 0.0283 0.0942
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0247 0.0247
Plasmodium vivax JmjC domain containing protein 0.0074 0.0247 0.8707
Echinococcus multilocularis GPCR, family 2 0.0072 0.0235 0.0235
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0173 0.0173
Leishmania major cathepsin L-like protease 0.0066 0.0211 0.1737
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.1203 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0107 0.0875
Echinococcus granulosus SAM and MBT domain containing protein 0.0057 0.0173 0.0173
Brugia malayi jmjC domain containing protein 0.0074 0.0247 0.0814
Echinococcus multilocularis snurportin 1 0.0318 0.1293 0.1293
Schistosoma mansoni loxhd1 0.0019 0.0011 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0604 0.2519 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.0426 0.0426
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0071 0.0227
Plasmodium vivax importin-beta 2, putative 0.003 0.0056 0.1907
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.024
Loa Loa (eye worm) hypothetical protein 0.0083 0.0283 0.0942
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0038 0.009 0.0299
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0037
Brugia malayi Bromodomain containing protein 0.0078 0.026 0.0859
Brugia malayi Muscleblind-like protein 0.0151 0.0575 0.1906
Echinococcus granulosus phd:f box containing protein 0.0074 0.0247 0.0247
Echinococcus granulosus RUN 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0151 0.0575 0.1912
Schistosoma mansoni hypothetical protein 0.0155 0.0591 0.0591
Echinococcus multilocularis neuropeptide s receptor 0.1064 0.4493 0.4493
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0604 0.2519 1
Plasmodium falciparum importin beta, putative 0.003 0.0056 0.219
Brugia malayi hypothetical protein 0.0173 0.0671 0.2226
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0034 0.0267
Trichomonas vaginalis chromobox protein, putative 0.008 0.0273 0.1076
Loa Loa (eye worm) hypothetical protein 0.0065 0.0207 0.0689
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0356 0.0356
Echinococcus granulosus hypothetical protein 0.0061 0.0189 0.0189
Schistosoma mansoni alpha-glucosidase 0.0137 0.0516 0.0516
Trypanosoma cruzi hypothetical protein, conserved 0.0083 0.0283 0.2341
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0604 0.2519 1
Brugia malayi intermediate filament protein 0.0062 0.0194 0.0639
Trypanosoma brucei hypothetical protein, conserved 0.0083 0.0283 0.2212
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0211 0.1598
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0211 0.1598
Echinococcus granulosus intermediate filament protein 0.0062 0.0194 0.0194
Trichomonas vaginalis penicillin-binding protein, putative 0.0083 0.0283 0.1117
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0056 0.0056
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0127 0.0496
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0074 0.0247 0.0247
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0034 0.0104
Schistosoma mansoni glutaminase 0.0284 0.1146 0.1146
Echinococcus multilocularis microtubule associated protein 2 0.2349 1 1
Schistosoma mansoni hypothetical protein 0.0072 0.0235 0.0235
Schistosoma mansoni transcription factor LCR-F1 0.008 0.0273 0.0273
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0173 0.0671 0.2232
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0025 0.0187
Loa Loa (eye worm) hypothetical protein 0.0083 0.0283 0.0942
Brugia malayi jmjC domain containing protein 0.0074 0.0247 0.0814
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0034 0.1312
Loa Loa (eye worm) hypothetical protein 0.0074 0.0247 0.0821
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0083 0.0283 0.0283
Trichomonas vaginalis glutaminase, putative 0.0284 0.1146 0.4546
Onchocerca volvulus Alhambra homolog 0.0034 0.0072 0.0393
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0032 0.0117
Loa Loa (eye worm) hypothetical protein 0.0072 0.0235 0.078
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.1203 1
Echinococcus granulosus neuropeptide receptor A26 0.1064 0.4493 0.4493
Brugia malayi latrophilin 2 splice variant baaae 0.0155 0.0591 0.1958
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.008 0.0644
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0072 0.0235 0.0774
Onchocerca volvulus 0.0062 0.0194 0.1076
Onchocerca volvulus 0.0019 0.0011 0.005
Echinococcus multilocularis musashi 0.0062 0.0194 0.0194
Trichomonas vaginalis D-aminoacylase, putative 0.0083 0.0283 0.1117
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.015 0.1233
Loa Loa (eye worm) hypothetical protein 0.0433 0.1785 0.5935
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0127 0.4437
Schistosoma mansoni polycystin 1-related 0.0019 0.0011 0.0011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0083 0.0283 0.0283
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.008 0.0307
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0072 0.0235 0.0235
Schistosoma mansoni hypothetical protein 0.0061 0.0189 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0121 0.0473
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0211 0.1598
Schistosoma mansoni protein phosphatase 2C 0.0074 0.0247 0.0247
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.0426 0.0426
Echinococcus multilocularis polycomb protein SCMH1 0.0057 0.0173 0.0173
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0074 0.0247 0.1904
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0211 0.1598
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.0136 0.075
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0056 0.0056
Echinococcus multilocularis lamin dm0 0.0062 0.0194 0.0194
Schistosoma mansoni hypothetical protein 0.0318 0.1293 0.1293
Echinococcus granulosus importin subunit beta 1 0.003 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0061 0.0189 0.0189
Loa Loa (eye worm) glutaminase 0.0284 0.1146 0.381
Onchocerca volvulus Huntingtin homolog 0.0267 0.1074 0.601
Brugia malayi Temporarily assigned gene name protein 44 0.0061 0.0189 0.062
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0186 0.1533
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0186
Loa Loa (eye worm) hypothetical protein 0.0061 0.0189 0.0627
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.008 0.0307
Schistosoma mansoni hypothetical protein 0.1264 0.535 0.535
Echinococcus multilocularis JmjC domain containing protein 4 0.0074 0.0247 0.0247
Schistosoma mansoni alpha glucosidase 0.0035 0.008 0.008
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0349 0.1423 0.1423
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0002 0.0002
Loa Loa (eye worm) ctsf protein 0.0017 0.0002 0.0007
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0023 0.0023
Echinococcus granulosus muscleblind protein 0.0151 0.0575 0.0575
Loa Loa (eye worm) latrophilin receptor protein 2 0.0072 0.0235 0.078
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0032 0.0117
Echinococcus multilocularis SAM and MBT domain containing protein 0.0057 0.0173 0.0173
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.0581 0.1924
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0072 0.0235 0.0235
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.008 0.0307
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0121 0.0668
Brugia malayi jmjC domain containing protein 0.0074 0.0247 0.0814
Plasmodium falciparum phd finger protein, putative 0.0034 0.0072 0.2864
Echinococcus multilocularis muscleblind protein 0.0151 0.0575 0.0575
Schistosoma mansoni phd/f-box containing protein 0.0074 0.0247 0.0247
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0056 0.0286
Loa Loa (eye worm) fibroinase 0.0017 0.0002 0.0007
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0056 0.0286
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0226 0.0898 0.2984
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0002 0.0002
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0011 0.0011
Schistosoma mansoni rab6-interacting 0.0019 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0024 0.0032 0.0117
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0101 0.0317
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0034 0.1142
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0083 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0083 0.0283 0.0942
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.0581 0.0581
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0356 0.0356
Loa Loa (eye worm) acetyltransferase 0.0152 0.0581 0.193
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.3327 0.3327
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0025 0.0082
Brugia malayi jmjC domain containing protein 0.0349 0.1423 0.4725
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0295 0.1193 1
Echinococcus granulosus peregrin 0.004 0.0098 0.0098
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0022 0.0022
Brugia malayi Bromodomain containing protein 0.004 0.0098 0.0319
Brugia malayi Calcitonin receptor-like protein seb-1 0.0226 0.0898 0.2978
Schistosoma mansoni hypothetical protein 0.0072 0.0235 0.0235
Leishmania major cathepsin L-like protease 0.0066 0.0211 0.1737
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.0581 0.0581
Brugia malayi Cytochrome P450 family protein 0.0023 0.0025 0.0075
Leishmania major cytochrome p450-like protein 0.0023 0.0025 0.0187
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.008 0.008
Echinococcus granulosus neuropeptide s receptor 0.1064 0.4493 0.4493
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0107 0.0722
Echinococcus multilocularis jumonji domain containing 1A 0.0074 0.0247 0.0247
Onchocerca volvulus 0.0035 0.008 0.0434
Schistosoma mansoni hypothetical protein 0.0072 0.0235 0.0235
Entamoeba histolytica hypothetical protein 0.008 0.0273 0.1074
Onchocerca volvulus 0.0057 0.0173 0.096
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0211 0.1737
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0604 0.2519 1
Echinococcus granulosus zinc finger protein 0.0023 0.0026 0.0026
Echinococcus multilocularis Protein lozenge 0.0054 0.0161 0.0161
Brugia malayi hypothetical protein 0.0061 0.0189 0.062
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.0795 0.0795
Echinococcus multilocularis lamin 0.0062 0.0194 0.0194
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0057 0.0173 0.0173
Mycobacterium ulcerans glutaminase 0.0284 0.1146 0.9596
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0072 0.2494
Schistosoma mansoni microtubule-associated protein tau 0.2349 1 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.0729 0.2421
Echinococcus multilocularis phd:f box containing protein 0.0074 0.0247 0.0247
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0074 0.0247 0.2038
Schistosoma mansoni ran 0.0022 0.0022 0.0022
Entamoeba histolytica Ran family GTPase 0.0022 0.0022 0.0079
Schistosoma mansoni alpha-glucosidase 0.0137 0.0516 0.0516
Toxoplasma gondii ABC1 family protein 0.0083 0.0283 1
Mycobacterium ulcerans esterase/lipase LipP 0.0083 0.0283 0.2214
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.008 0.0644
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0072 0.0072
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0173 0.0173
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0107 0.0875
Trichomonas vaginalis chromobox protein, putative 0.008 0.0273 0.1076
Loa Loa (eye worm) hypothetical protein 0.0267 0.1074 0.357
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0072 0.0072
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.0194 0.0645
Loa Loa (eye worm) jmjC domain-containing protein 0.0281 0.1133 0.3764
Echinococcus multilocularis cysteine protease 0.0017 0.0002 0.0002
Echinococcus granulosus lysine specific demethylase 5A 0.0281 0.1133 0.1133
Echinococcus granulosus JmjC domain containing protein 4 0.0074 0.0247 0.0247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0356 0.0356
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0604 0.2519 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0356 0.0356
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.0194 0.0639
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0295 0.1193 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0532 0.4407
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0127 0.4437
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0011 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0604 0.2519 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0283 0.0942

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 4.9 Inhibition of Chk1 ChEMBL. 19385614

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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