Detailed information for compound 1058743

Basic information

Technical information
  • TDR Targets ID: 1058743
  • Name: 5-amino-N-(furan-2-ylmethyl)-1-[2-[(2-methylp henyl)amino]-2-oxoethyl]triazole-4-carboxamid e
  • MW: 354.363 | Formula: C17H18N6O3
  • H donors: 3 H acceptors: 4 LogP: 1.47 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1nnc(c1N)C(=O)NCc1ccco1)Nc1ccccc1C
  • InChi: 1S/C17H18N6O3/c1-11-5-2-3-7-13(11)20-14(24)10-23-16(18)15(21-22-23)17(25)19-9-12-6-4-8-26-12/h2-8H,9-10,18H2,1H3,(H,19,25)(H,20,24)
  • InChiKey: VIQYCATYUJQXPX-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-amino-N-(2-furylmethyl)-1-[2-[(2-methylphenyl)amino]-2-oxo-ethyl]triazole-4-carboxamide
  • 5-amino-N-(2-furylmethyl)-1-[2-[(2-methylphenyl)amino]-2-oxoethyl]-4-triazolecarboxamide
  • 5-amino-N-(2-furylmethyl)-1-[2-keto-2-[(2-methylphenyl)amino]ethyl]triazole-4-carboxamide
  • 5-amino-N-(furan-2-ylmethyl)-1-[2-[(2-methylphenyl)amino]-2-oxo-ethyl]-1,2,3-triazole-4-carboxamide
  • NCGC00108091-01
  • 5-amino-N-(2-furylmethyl)-1-{2-[(2-methylphenyl)amino]-2-oxoethyl}-1H-1,2,3-triazole-4-carboxamide
  • MLS000730776
  • SMR000309151
  • C368-0105

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0053 0.1249
Loa Loa (eye worm) helicase 0.0024 0.0001 0.0053
Brugia malayi hypothetical protein 0.0104 0.0049 0.0067
Mycobacterium tuberculosis Conserved protein 0.011 0.0053 0.1249
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0019 0.0441
Brugia malayi Patched protein homolog 1 0.0025 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0075 0.0032 0.135
Mycobacterium ulcerans acyl-CoA synthetase 0.01 0.0047 0.2861
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0004 0.006
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0004 0.002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.01 0.0047 0.2861
Entamoeba histolytica hypothetical protein 0.0024 0.0001 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0054 0.0019 0.0446
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Brugia malayi Patched family protein 0.0025 0.0002 0.0002
Loa Loa (eye worm) patched family protein 0.0025 0.0002 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0037 0.2222
Mycobacterium leprae Probable lipase LipE 0.011 0.0053 0.7129
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0053 0.2244
Giardia lamblia Fructose-bisphosphate aldolase 0.0291 0.0162 0.0511
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0058 0.2452
Echinococcus granulosus Protein patched homolog 1 0.0177 0.0093 0.2185
Echinococcus granulosus microtubule associated protein 2 0.0731 0.0426 1
Brugia malayi hypothetical protein 0.0025 0.0002 0.0002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0053 0.1249
Loa Loa (eye worm) hypothetical protein 0.0071 0.0029 0.1236
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.0033 0.1403
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0038 0.4934
Echinococcus granulosus protection of telomeres protein 1 0.0525 0.0302 0.7084
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0015 0.0072
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0009 0.003
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0053 0.3249
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0029 0.0004 0.006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0001 0.0053
Loa Loa (eye worm) hypothetical protein 0.0029 0.0004 0.018
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0249 0.0136 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0001 0.0022
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0008 0.0039
Loa Loa (eye worm) hypothetical protein 0.0029 0.0004 0.0186
Brugia malayi Pre-SET motif family protein 0.003 0.0005 0.0006
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0015 0.0349
Brugia malayi hypothetical protein 0.0365 0.0206 0.0283
Brugia malayi Patched family protein 0.0025 0.0002 0.0002
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0001 0.0022
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0001 0.0022
Brugia malayi glutathione reductase 0.0037 0.0009 0.0013
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0029 0.0004 0.006
Echinococcus granulosus chromobox protein 2 0.0024 0.0001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0041 0.0011 0.0471
Loa Loa (eye worm) hypothetical protein 0.0024 0.0001 0.0053
Trichomonas vaginalis esterase, putative 0.011 0.0053 0.3221
Brugia malayi Patched related family protein 4 0.0025 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0015 0.0343
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0001 0.0022
Loa Loa (eye worm) jmjC domain-containing protein 0.0128 0.0064 0.2712
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0032 0.0157
Loa Loa (eye worm) oxidoreductase 0.0029 0.0004 0.0186
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0022 0.0109
Echinococcus multilocularis peregrin 0.0064 0.0025 0.0123
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0162 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0075 0.0032 0.5
Schistosoma mansoni hypothetical protein 0.0055 0.0019 0.0454
Loa Loa (eye worm) hypothetical protein 0.0075 0.0032 0.135
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0032 0.0754
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0004 0.006
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Plasmodium falciparum importin beta, putative 0.0029 0.0004 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0041 0.0964
Toxoplasma gondii patched family protein 0.0025 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Leishmania major hypothetical protein, conserved 0.0055 0.002 0.0069
Plasmodium vivax SET domain protein, putative 0.003 0.0005 0.0012
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0024 0.0084
Toxoplasma gondii thioredoxin reductase 0.0037 0.0009 0.0029
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0029 0.0004 0.0011
Brugia malayi mbt repeat family protein 0.0047 0.0015 0.0021
Echinococcus granulosus lysine specific demethylase 5A 0.0077 0.0033 0.077
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0001 0.0015
Schistosoma mansoni jumonji domain containing protein 0.0162 0.0084 0.1963
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0005 0.0021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0009 0.0045
Loa Loa (eye worm) patched family protein 0.0025 0.0002 0.0073
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Brugia malayi hypothetical protein 0.0025 0.0002 0.0002
Schistosoma mansoni survival motor neuron protein 0.0055 0.0019 0.0454
Brugia malayi Patched family protein 0.0025 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0054 0.0019 0.0806
Loa Loa (eye worm) hypothetical protein 0.0024 0.0001 0.0053
Echinococcus multilocularis geminin 0.0688 0.04 0.1951
Mycobacterium ulcerans hypothetical protein 0.01 0.0047 0.2861
Brugia malayi AMP-binding enzyme family protein 0.01 0.0047 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0001 0.0022
Loa Loa (eye worm) hypothetical protein 0.011 0.0053 0.2244
Loa Loa (eye worm) hypothetical protein 0.0024 0.0001 0.0053
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Brugia malayi mbt repeat family protein 0.0047 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0075 0.0032 0.135
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0001 0.0022
Trypanosoma brucei trypanothione reductase 0.0037 0.0009 0.0018
Schistosoma mansoni hypothetical protein 0.0079 0.0034 0.0794
Entamoeba histolytica acyl-CoA synthetase, putative 0.01 0.0047 0.1968
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0009 0.0029
Brugia malayi Patched family protein 0.0025 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0001 0.0053
Loa Loa (eye worm) hypothetical protein 0.0083 0.0037 0.156
Mycobacterium ulcerans acyl-CoA synthetase 0.01 0.0047 0.2861
Mycobacterium ulcerans lipase LipD 0.011 0.0053 0.3249
Loa Loa (eye worm) PHD-finger family protein 0.0062 0.0024 0.102
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0002 0.0011
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0001 0.0006
Plasmodium vivax telomerase reverse transcriptase, putative 0.4552 0.2722 1
Loa Loa (eye worm) heterochromatin protein 1 0.0148 0.0076 0.3228
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0004 0.0013
Brugia malayi Niemann-Pick C1 protein precursor 0.0413 0.0235 0.0323
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.0089 0.0122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0162 1
Brugia malayi hypothetical protein 0.0055 0.002 0.0027
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.01 0.0047 0.2861
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0015 0.0343
Schistosoma mansoni hypothetical protein 0.0171 0.0089 0.2095
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0029 0.0672
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0001 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0162 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0001 0.0022
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0053 0.1249
Loa Loa (eye worm) hypothetical protein 0.011 0.0053 0.2244
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0022 0.1314
Brugia malayi PHD-finger family protein 0.0025 0.0002 0.0002
Brugia malayi Patched family protein 0.0025 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.0072 0.4558
Plasmodium falciparum thioredoxin reductase 0.0037 0.0009 0.0029
Loa Loa (eye worm) hypothetical protein 0.0106 0.0051 0.2155
Entamoeba histolytica acyl-CoA synthetase, putative 0.01 0.0047 0.1968
Brugia malayi Bromodomain containing protein 0.0075 0.0032 0.0043
Loa Loa (eye worm) hypothetical protein 0.0024 0.0001 0.0053
Echinococcus multilocularis Niemann Pick C1 protein 0.059 0.0341 0.1666
Brugia malayi PHD-finger family protein 0.0062 0.0024 0.0033
Loa Loa (eye worm) patched family protein 0.0025 0.0002 0.0073
Schistosoma mansoni hypothetical protein 0.0104 0.0049 0.1144
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0034 0.0165
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.0072 0.1728
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0004 0.0215
Entamoeba histolytica acyl-coA synthetase, putative 0.01 0.0047 0.1968
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0004 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0001 0.0022
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0022 0.0523
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Trichomonas vaginalis chromobox protein, putative 0.009 0.004 0.2458
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.0072 1
Schistosoma mansoni bromodomain containing protein 0.0063 0.0025 0.0573
Onchocerca volvulus Alhambra homolog 0.0062 0.0024 0.0023
Entamoeba histolytica hypothetical protein 0.0076 0.0032 0.134
Brugia malayi Patched related family protein 12 0.0025 0.0002 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0058 0.2452
Brugia malayi Patched related family protein 10 0.0025 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.011 0.0053 0.2244
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0001 0.0022
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0024 0.0001 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0029 0.0672
Echinococcus granulosus snurportin 1 0.0312 0.0174 0.4087
Toxoplasma gondii hypothetical protein 0.0025 0.0002 0.0002
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0009 0.0217
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0034 0.0047
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0004 0.0087
Loa Loa (eye worm) hypothetical protein 0.0249 0.0136 0.58
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0053 0.1249
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0015 0.0639
Mycobacterium tuberculosis Conserved protein 0.011 0.0053 0.1249
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0022 0.1314
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0034 0.0047
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.4552 0.2722 1
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0053 0.3221
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0053 0.1234
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.002 0.0068
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0015 0.0349
Loa Loa (eye worm) hypothetical protein 0.0024 0.0001 0.0053
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0004 0.0013
Plasmodium falciparum telomerase reverse transcriptase 0.4552 0.2722 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.0037 0.0035
Onchocerca volvulus 0.01 0.0047 0.0046
Leishmania major 4-coumarate:coa ligase-like protein 0.01 0.0047 0.0169
Onchocerca volvulus 0.0047 0.0015 0.0014
Onchocerca volvulus 0.0104 0.0049 0.0048
Brugia malayi Bromodomain containing protein 0.0038 0.001 0.0013
Schistosoma mansoni hypothetical protein 0.0079 0.0034 0.0794
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Brugia malayi hypothetical protein 0.0076 0.0032 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0004 0.0006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0034 0.1447
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0249 0.0136 0.58
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0162 1
Onchocerca volvulus 0.0029 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0004 0.0006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.0033 0.077
Brugia malayi Patched family protein 0.0025 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0047 0.0015 0.0628
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0413 0.0235 1
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0053 0.1234
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0029 0.0004 0.006
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0062 0.0024 0.102
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0009 0.0177
Toxoplasma gondii RNA-directed DNA polymerase 0.4552 0.2722 1
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0015 0.0349
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.0098 0.0479
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0004 0.0006
Brugia malayi Thioredoxin reductase 0.0037 0.0009 0.0013
Onchocerca volvulus 0.0236 0.0129 0.0127
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0001 0.0022
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.002 0.0068
Echinococcus multilocularis lysine specific demethylase 5A 0.0075 0.0032 0.0155
Plasmodium vivax glutathione reductase, putative 0.0037 0.0009 0.0029
Mycobacterium tuberculosis Probable reductase 0.0085 0.0038 0.0883
Brugia malayi Valyl-tRNA synthetase 0.0024 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0065 0.0026 0.11
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0029 0.0004 0.006
Toxoplasma gondii ABC1 family protein 0.011 0.0053 0.0189
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0001 0.0001
Toxoplasma gondii patched family protein 0.0025 0.0002 0.0002
Schistosoma mansoni chromobox protein 0.0148 0.0076 0.1777
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0162 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0203 0.0109 0.0531
Brugia malayi Calcitonin receptor-like protein seb-1 0.0249 0.0136 0.0188
Schistosoma mansoni chromobox protein 0.0148 0.0076 0.1777
Loa Loa (eye worm) hypothetical protein 0.0075 0.0032 0.135
Loa Loa (eye worm) hypothetical protein 0.01 0.0047 0.1999
Schistosoma mansoni hypothetical protein 0.0312 0.0174 0.4087
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0075 0.0032 0.1837
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0038 0.0883
Brugia malayi chromobox protein homolog 3 0.0083 0.0037 0.005
Schistosoma mansoni hypothetical protein 0.0171 0.0089 0.2095
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0053 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0001 0.0022
Brugia malayi Patched family protein 0.0025 0.0002 0.0002
Echinococcus granulosus chromobox protein 1 0.0148 0.0076 0.1777
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Loa Loa (eye worm) hypothetical protein 0.0365 0.0206 0.8767
Echinococcus granulosus tumor protein p63 0.0713 0.0415 0.9739
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0038 0.0883
Plasmodium vivax acetyl-CoA synthetase, putative 0.0029 0.0004 0.0011
Plasmodium vivax hypothetical protein, conserved 0.011 0.0053 0.0189
Mycobacterium leprae conserved hypothetical protein 0.011 0.0053 0.7129
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0075 0.0032 0.0733
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0029 0.0004 0.0148
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0002 0.0052
Leishmania major 4-coumarate:coa ligase-like protein 0.01 0.0047 0.0169
Entamoeba histolytica hypothetical protein 0.0024 0.0001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0079 0.0034 0.1447
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0001 0.0022
Echinococcus granulosus PHD finger protein rhinoceros 0.0062 0.0024 0.0559
Giardia lamblia Telomerase catalytic subunit 0.4552 0.2722 1
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0015 0.0349
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0038 0.0883
Brugia malayi Telomerase reverse transcriptase 1.2114 0.7265 1
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0053 0.019
Plasmodium vivax acyl-CoA synthetase, putative 0.0075 0.0032 0.0112
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0015 0.0071
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.0033 0.077
Brugia malayi beta-lactamase family protein 0.011 0.0053 0.0073
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0004 0.0011
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0001 0.0022
Leishmania major hypothetical protein, conserved 0.011 0.0053 0.019
Schistosoma mansoni hypothetical protein 0.0688 0.04 0.9386
Onchocerca volvulus 0.011 0.0053 0.0051
Brugia malayi RNA, U transporter 1 0.0083 0.0037 0.005
Brugia malayi hypothetical protein 0.0025 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0012 0.052
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0413 0.0235 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0053 0.1249
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0024 0.0084
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Loa Loa (eye worm) hypothetical protein 0.01 0.0047 0.1999
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.01 0.0047 0.1107
Loa Loa (eye worm) patched family protein 0.0025 0.0002 0.0073
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0002 0.0102
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0029 0.0004 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0001 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.0093 0.5737
Loa Loa (eye worm) hypothetical protein 0.011 0.0053 0.2244
Echinococcus multilocularis microtubule associated protein 2 0.0731 0.0426 0.2079
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0009 0.0387
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0162 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0004 0.0006
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0004 0.0013
Schistosoma mansoni niemann-pick C1 (NPC1) 0.042 0.0239 0.5603
Plasmodium falciparum glutathione reductase 0.0037 0.0009 0.0029
Plasmodium falciparum acyl-CoA synthetase 0.0075 0.0032 0.0112
Mycobacterium tuberculosis Conserved protein 0.011 0.0053 0.1249
Brugia malayi Patched family protein 0.0025 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0005 0.0103
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0029 0.0004 0.006
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.002 0.0069
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0004 0.0013
Onchocerca volvulus 0.0029 0.0004 0.0003
Brugia malayi beta-lactamase 0.011 0.0053 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0001 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0041 0.02
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0004 0.0215
Brugia malayi CHE-14 protein 0.0177 0.0093 0.0128
Entamoeba histolytica hypothetical protein 0.0076 0.0032 0.134
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0001 0.0015
Schistosoma mansoni chromobox protein 0.0024 0.0001 0.0026
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0019 0.0441
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0029 0.0004 0.0006
Echinococcus granulosus Chromobox protein 3 0.0024 0.0001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0047 0.0015 0.0639
Trypanosoma brucei telomerase reverse transcriptase 0.4552 0.2722 1
Brugia malayi hypothetical protein 0.0035 0.0008 0.0011
Echinococcus multilocularis chromobox protein 1 0.0148 0.0076 0.0369
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0029 0.0004 0.0011
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0015 0.0072
Onchocerca volvulus 0.011 0.0053 0.0051
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.0162 0.6874
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0044 0.1024
Plasmodium vivax importin-beta 2, putative 0.0029 0.0004 0.0011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0111 0.474
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0029 0.0004 0.006
Echinococcus granulosus chromobox protein 1 0.0148 0.0076 0.1777
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0019 0.0027
Onchocerca volvulus 0.0029 0.0004 0.0003
Plasmodium vivax patched family protein, putative 0.0025 0.0002 0.0002
Brugia malayi Bromodomain containing protein 0.0064 0.0025 0.0035
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0044 0.1024
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0024 0.0001 0.0002
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.002 0.0069
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0001 0.0026
Brugia malayi AMP-binding enzyme family protein 0.01 0.0047 0.0065
Brugia malayi Patched family protein 0.0025 0.0002 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0053 0.1234
Echinococcus multilocularis Niemann Pick C1 protein 0.0413 0.0235 0.1146
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0041 0.0057
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0004 0.0013
Echinococcus multilocularis GPCR, family 2 0.0079 0.0034 0.0165
Echinococcus granulosus expressed conserved protein 0.0388 0.022 0.5159
Onchocerca volvulus 0.0029 0.0004 0.0003
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0053 0.1249
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0041 0.02
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0053 0.3221
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0004 0.0006
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0038 0.0883
Loa Loa (eye worm) beta-lactamase 0.011 0.0053 0.2244
Schistosoma mansoni hypothetical protein 0.0287 0.0159 0.373
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.01 0.0047 0.2861
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0029 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0004 0.0186
Loa Loa (eye worm) glutathione reductase 0.0037 0.0009 0.0387
Entamoeba histolytica hypothetical protein 0.0076 0.0032 0.134
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Echinococcus multilocularis expressed conserved protein 0.0388 0.022 0.1072
Brugia malayi Pre-SET motif family protein 0.0208 0.0111 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.009 0.554
Brugia malayi Myosin head containing protein 0.0025 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0004 0.0186
Brugia malayi SET domain containing protein 0.0025 0.0002 0.0003
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.002 0.0057
Loa Loa (eye worm) glutaminase 0.0277 0.0153 0.6522
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0053 0.3221
Echinococcus granulosus jumonji domain containing protein 0.0086 0.0039 0.0902
Echinococcus multilocularis tumor protein p63 0.0713 0.0415 0.2024
Echinococcus multilocularis protection of telomeres protein 1 0.0525 0.0302 0.1472
Brugia malayi Patched family protein 0.0025 0.0002 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0041 0.0964
Loa Loa (eye worm) MBCTL1 0.0054 0.0019 0.0806
Leishmania major telomerase reverse transcriptase, putative 0.4552 0.2722 1
Brugia malayi M-phase phosphoprotein, mpp8 0.0024 0.0001 0.0002
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0053 0.0257
Schistosoma mansoni hypothetical protein 0.0076 0.0032 0.0754
Toxoplasma gondii propionate-CoA ligase 0.0029 0.0004 0.0011
Echinococcus granulosus geminin 0.0688 0.04 0.9386
Brugia malayi protein C24B5.3 0.0025 0.0002 0.0002
Onchocerca volvulus 0.0054 0.0019 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0029 0.0672
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.0174 0.7415
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0053 0.3221
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.01 0.0047 0.6278
Echinococcus multilocularis survival motor neuron protein 1 0.0268 0.0148 0.072
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.01 0.0047 0.6278
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0019 0.0441
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0019 0.0026
Brugia malayi Patched family protein 0.0025 0.0002 0.0002
Echinococcus multilocularis sterol regulatory element binding protein 0.0177 0.0093 0.0454
Brugia malayi Patched family protein 0.0025 0.0002 0.0002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0032 0.0754
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0177 0.0093 0.0128
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0001 0.0022
Echinococcus multilocularis snurportin 1 0.0312 0.0174 0.0849
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0029 0.0672
Toxoplasma gondii patched family protein 0.0025 0.0002 0.0002
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0019 0.0092
Loa Loa (eye worm) hypothetical protein 0.011 0.0053 0.2244
Brugia malayi protein C24B5.3 0.0025 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0104 0.0049 0.208
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0001 0.0015
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0001 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0162 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.009 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0177 0.0093 0.3956
Schistosoma mansoni hypothetical protein 0.0171 0.0089 0.2095
Schistosoma mansoni microtubule-associated protein tau 0.0731 0.0426 1
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.002 0.0068
Echinococcus granulosus GPCR family 2 0.0079 0.0034 0.0794
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0037 0.2222
Loa Loa (eye worm) hypothetical protein 0.0217 0.0117 0.4988
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0015 0.0349
Brugia malayi jmjC domain containing protein 0.0203 0.0109 0.015
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0029 0.0004 0.006
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0001 0.003
Trichomonas vaginalis hypothetical protein 0.0024 0.0001 0.0022
Brugia malayi beta-lactamase family protein 0.011 0.0053 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0001 0.0022
Loa Loa (eye worm) hypothetical protein 0.011 0.0053 0.2244
Trichomonas vaginalis chromobox protein, putative 0.009 0.004 0.2458
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0001 0.0022
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0702 0.0409 1
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0053 0.3221
Brugia malayi hypothetical protein 0.0268 0.0148 0.0203
Echinococcus granulosus importin subunit beta 1 0.0029 0.0004 0.0095
Schistosoma mansoni chromobox protein 0.0024 0.0001 0.0026
Loa Loa (eye worm) patched family protein 0.0025 0.0002 0.0073
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.4552 0.2722 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0004 0.0013
Onchocerca volvulus 0.0365 0.0206 0.0205
Echinococcus multilocularis PHD finger protein rhinoceros 0.0062 0.0024 0.0116
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0041 0.1755
Brugia malayi Heterochromatin protein 1 0.0148 0.0076 0.0104
Schistosoma mansoni patched 1 0.0177 0.0093 0.2185
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0162 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0049 0.208
Loa Loa (eye worm) hypothetical protein 0.0268 0.0148 0.6284
Schistosoma mansoni hypothetical protein 0.017 0.0089 0.2084
Loa Loa (eye worm) hypothetical protein 0.0075 0.0032 0.135
Brugia malayi jmjC domain containing protein 0.0077 0.0033 0.0045
Echinococcus granulosus Chromo domain 0.0024 0.0001 0.0026
Echinococcus granulosus Niemann Pick C1 protein 0.059 0.0341 0.8015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0034 0.0794
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.01 0.0047 0.1107
Trichomonas vaginalis Heterochromatin protein, putative 0.0024 0.0001 0.0022
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0001 0.0026
Echinococcus granulosus survival motor neuron protein 1 0.0268 0.0148 0.3463
Mycobacterium ulcerans hypothetical protein 0.011 0.0053 0.3249
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0062 0.0024 0.0559
Onchocerca volvulus 0.0055 0.0019 0.0018
Trichomonas vaginalis chromobox protein, putative 0.0148 0.0076 0.4658
Onchocerca volvulus 0.011 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Echinococcus multilocularis chromobox protein 2 0.0024 0.0001 0.0005
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3432 0.2049 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0034 0.0165
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0001 0.0022
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0029 0.0004 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0001 0.0022
Trichomonas vaginalis glutaminase, putative 0.0277 0.0153 0.9467
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0041 0.0964
Schistosoma mansoni hypothetical protein 0.0688 0.04 0.9386
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0002 0.0052
Brugia malayi AMP-binding enzyme family protein 0.01 0.0047 0.0065
Schistosoma mansoni hypothetical protein 0.0079 0.0034 0.0794
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0053 0.0178
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.002 0.0068
Echinococcus multilocularis Chromo domain 0.0024 0.0001 0.0005
Echinococcus multilocularis Chromobox protein 3 0.0024 0.0001 0.0005
Schistosoma mansoni cellular tumor antigen P53 0.0104 0.0049 0.1155
Echinococcus granulosus sterol regulatory element binding protein 0.0177 0.0093 0.2185
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0203 0.0109 0.2553
Echinococcus multilocularis jumonji domain containing protein 0.0086 0.0039 0.0188
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0024 0.0001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.001 0.0411
Loa Loa (eye worm) hypothetical protein 0.017 0.0089 0.3785
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Brugia malayi Patched family protein 0.0025 0.0002 0.0002
Brugia malayi Patched family protein 0.0025 0.0002 0.0002
Trichomonas vaginalis chromobox protein, putative 0.0148 0.0076 0.4658
Mycobacterium ulcerans glutaminase 0.0277 0.0153 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0015 0.0343
Onchocerca volvulus 0.0024 0.0001 0.00000000074915
Entamoeba histolytica hypothetical protein 0.0076 0.0032 0.134
Brugia malayi hypothetical protein 0.0025 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0055 0.002 0.0837
Echinococcus granulosus Niemann Pick C1 protein 0.0413 0.0235 0.5513
Leishmania major 4-coumarate:coa ligase-like protein 0.01 0.0047 0.0169
Plasmodium falciparum phd finger protein, putative 0.0062 0.0024 0.0084
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0053 0.0073
Brugia malayi CHD4 protein 0.0026 0.0002 0.0003
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0038 0.0883
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0005 0.0012
Echinococcus multilocularis chromobox protein 1 0.0148 0.0076 0.0369
Schistosoma mansoni hypothetical protein 0.0079 0.0034 0.0794
Leishmania major trypanothione reductase 0.0037 0.0009 0.003
Echinococcus multilocularis protein patched 0.0177 0.0093 0.0454
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0034 0.0794
Onchocerca volvulus 0.0065 0.0026 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0041 0.0964
Echinococcus multilocularis protein dispatched 1 0.0202 0.0108 0.0528
Schistosoma mansoni hypothetical protein 0.0171 0.0089 0.2095
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0044 0.5776
Treponema pallidum fructose-bisphosphate aldolase 0.0291 0.0162 0.5
Brugia malayi Protein cec-1. 0.0024 0.0001 0.0002
Brugia malayi glutaminase DH11.1 0.0277 0.0153 0.0211
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0104 0.0049 0.21
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0008 0.0188
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0129 0.7937
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Schistosoma mansoni glutaminase 0.0277 0.0153 0.3594
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0001 0.0022
Brugia malayi hypothetical protein 0.0024 0.0001 0.0002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.01 0.0047 0.2861
Schistosoma mansoni hypothetical protein 0.0062 0.0024 0.0559
Entamoeba histolytica hypothetical protein 0.0024 0.0001 0.0015
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0029 0.0004 0.002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0044 0.1024
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.0162 0.6874
Brugia malayi MH2 domain containing protein 0.0118 0.0058 0.0079
Schistosoma mansoni hypothetical protein 0.0025 0.0001 0.003
Loa Loa (eye worm) hypothetical protein 0.01 0.0047 0.1999
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0004 0.0186
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.0098 0.2306
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0177 0.0093 0.3967
Plasmodium falciparum lipid/sterol:H+ symporter 0.0025 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Echinococcus granulosus peregrin 0.0064 0.0025 0.0592
Brugia malayi hypothetical protein 0.0104 0.0049 0.0067
Schistosoma mansoni importin beta-1 0.0029 0.0004 0.0095
Brugia malayi Patched family protein 0.0025 0.0002 0.0002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0053 0.3249
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0053 0.1249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0004 0.006
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0024 0.0084
Toxoplasma gondii patched family protein 0.0025 0.0002 0.0002
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0004 0.0013
Mycobacterium ulcerans beta-lactamase 0.011 0.0053 0.3249
Mycobacterium ulcerans acyl-CoA synthetase 0.01 0.0047 0.2861
Schistosoma mansoni acetyl-CoA synthetase 0.0029 0.0004 0.0099
Loa Loa (eye worm) hypothetical protein 0.0177 0.0093 0.3967
Brugia malayi Associated with TFs and helicases family protein 0.0024 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0024 0.0001 0.0026
Loa Loa (eye worm) glutaminase 2 0.0277 0.0153 0.6522
Loa Loa (eye worm) hypothetical protein 0.0025 0.0002 0.0073
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0041 0.0964
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0019 0.0092

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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