Detailed information for compound 1064745

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 609.716 | Formula: C31H43N7O6
  • H donors: 2 H acceptors: 7 LogP: 0.35 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCOC(=O)N1CCN(CC1)C(=O)[C@@H](NC(=O)c1cc(nc(n1)c1ccccc1)N1CCN(CC1)C)CCC(=O)O
  • InChi: 1S/C31H43N7O6/c1-3-4-8-21-44-31(43)38-19-17-37(18-20-38)30(42)24(11-12-27(39)40)33-29(41)25-22-26(36-15-13-35(2)14-16-36)34-28(32-25)23-9-6-5-7-10-23/h5-7,9-10,22,24H,3-4,8,11-21H2,1-2H3,(H,33,41)(H,39,40)/t24-/m0/s1
  • InChiKey: NDKVFAXEDFVNPY-DEOSSOPVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens purinergic receptor P2Y, G-protein coupled, 12 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0475 0.0213
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0001 0.0027
Onchocerca volvulus Pyruvate kinase homolog 0.0112 0.0391 0.0391
Schistosoma mansoni rotamase 0.0036 0.008 0.0135
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0046 0.0152
Loa Loa (eye worm) hypothetical protein 0.0115 0.0402 0.0402
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0001 0.0002
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0046 0.0122 0.0183
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0099 0.0335 0.0335
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0016 0.0028
Giardia lamblia Fructose-bisphosphate aldolase 0.1331 0.5365 0.5365
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0229 0.0229
Echinococcus multilocularis survival motor neuron protein 1 0.0773 0.3089 0.4635
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0084 0.0274 0.0274
Trichomonas vaginalis rotamase, putative 0.0035 0.0077 0.0077
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0099 0.0335 0.0561
Entamoeba histolytica hypothetical protein 0.0073 0.0229 0.0229
Mycobacterium tuberculosis Probable lipase LipE 0.0115 0.0402 0.0582
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0112 0.0388 0.1278
Plasmodium falciparum telomerase reverse transcriptase 0.0065 0.0198 0.5058
Loa Loa (eye worm) hypothetical protein 0.0084 0.0274 0.0274
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0361 0.0361
Leishmania major basic transcription factor 3a, putative 0.0073 0.0229 0.0753
Brugia malayi Steroid receptor seven-up type 2 0.0099 0.0335 0.0335
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0213 0.0357
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0046 0.1182
Loa Loa (eye worm) hypothetical protein 0.004 0.0097 0.0097
Schistosoma mansoni kinase 0.0054 0.0152 0.0255
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0073 0.1879
Echinococcus multilocularis lamin dm0 0.0059 0.0174 0.0261
Entamoeba histolytica protein tyrosine phosphatase, putative 0.2466 1 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0001 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0115 0.0402 1
Brugia malayi Bromodomain containing protein 0.0078 0.0251 0.0251
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0232 0.039
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0052 0.0145 0.0243
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0128 0.0215
Trichomonas vaginalis esterase, putative 0.0115 0.0402 0.0402
Schistosoma mansoni steroid hormone receptor ad4bp 0.0099 0.0335 0.0561
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0001 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0059 0.0099
Brugia malayi jmjC domain containing protein 0.0063 0.0191 0.0191
Onchocerca volvulus 0.0046 0.0122 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.0402 0.1323
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0077 0.0254
Echinococcus granulosus geminin 0.0773 0.3088 0.5175
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0122
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0084 0.0274 0.0411
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.065 0.2586 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0099 0.0335 0.0335
Mycobacterium ulcerans esterase/lipase LipP 0.0115 0.0402 0.0138
Schistosoma mansoni hypothetical protein 0.002 0.0016 0.0027
Loa Loa (eye worm) hypothetical protein 0.0115 0.0402 0.0402
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0146 0.0146
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0001 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0099 0.0335 0.0502
Trypanosoma brucei polo-like protein kinase 0.0105 0.0361 0.1188
Plasmodium falciparum basic transcription factor 3b, putative 0.0073 0.0229 0.5849
Onchocerca volvulus 0.0237 0.0898 0.0898
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0099 0.0335 0.0335
Onchocerca volvulus Protein ultraspiracle homolog 0.0099 0.0335 0.0335
Mycobacterium ulcerans lipase LipD 0.0115 0.0402 0.0138
Brugia malayi Nuclear hormone receptor E75 0.0046 0.0122 0.0122
Brugia malayi Pre-SET motif family protein 0.0208 0.0782 0.0782
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0128 0.0192
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0264 0.1011 0.1011
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0052 0.0145 0.0217
Brugia malayi hypothetical protein 0.0028 0.0046 0.0046
Onchocerca volvulus 0.0115 0.0402 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0099 0.0335 0.0335
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0099 0.0335 0.0561
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1331 0.5365 0.5365
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0046 0.0152
Loa Loa (eye worm) RNA binding protein 0.0073 0.0232 0.0232
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0099 0.0335 0.0561
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0122
Schistosoma mansoni pyruvate kinase 0.0112 0.0391 0.0655
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0122
Loa Loa (eye worm) pyruvate kinase 0.0112 0.0391 0.0391
Echinococcus multilocularis pyruvate kinase 0.0058 0.0168 0.0251
Schistosoma mansoni ap endonuclease 0.0082 0.0267 0.0448
Trypanosoma cruzi pyruvate kinase 2, putative 0.0112 0.0391 0.1287
Loa Loa (eye worm) hypothetical protein 0.0099 0.0335 0.0335
Onchocerca volvulus 0.0063 0.019 0.019
Brugia malayi ecdysone receptor 0.0046 0.0122 0.0122
Echinococcus granulosus ecdysone induced protein 78C 0.0099 0.0335 0.0561
Loa Loa (eye worm) hypothetical protein 0.0052 0.0145 0.0145
Plasmodium vivax basic transcription factor 3b, putative 0.0073 0.0229 0.569
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0024 0.0036
Echinococcus multilocularis pyruvate kinase 0.0058 0.0168 0.0251
Onchocerca volvulus 0.0059 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0099 0.0335 0.0335
Mycobacterium tuberculosis Conserved protein 0.0115 0.0402 0.0582
Mycobacterium tuberculosis Conserved protein 0.0115 0.0402 0.0582
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.0361 0.1188
Leishmania major hypothetical protein, conserved 0.0028 0.0046 0.0152
Schistosoma mansoni hypothetical protein 0.0897 0.3596 0.6027
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0475 0.0795
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0226 0.0854 0.143
Echinococcus granulosus muscleblind protein 0.108 0.4341 0.7275
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0734 0.293 0.4249
Mycobacterium tuberculosis Probable esterase LipL 0.0115 0.0402 0.0582
Brugia malayi CXXC zinc finger family protein 0.0063 0.019 0.019
Echinococcus granulosus nuclear receptor nhr 48 0.0046 0.0122 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0099 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0049
Onchocerca volvulus Bile acid receptor homolog 0.0099 0.0335 0.0335
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.076 0.3036 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0122
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0082 0.0267 0.0881
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0191 0.032
Giardia lamblia Telomerase catalytic subunit 0.0065 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0099 0.0335 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0099 0.0335 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0099 0.0335 0.0335
Echinococcus multilocularis pyruvate kinase 0.0089 0.0294 0.0441
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.0697 0.1168
Brugia malayi nuclear receptor NHR-88 0.0046 0.0122 0.0122
Toxoplasma gondii pyruvate kinase PyKII 0.0058 0.0168 0.3532
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0001 0.0001
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0475 0.0795
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0001 0.0003
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0191 0.032
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0001 0.0002
Echinococcus multilocularis transcription factor btf3 0.0073 0.0229 0.0343
Leishmania major telomerase reverse transcriptase, putative 0.0065 0.0198 0.0651
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0189 0.0317
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0082 0.0267 0.0881
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0099 0.0335 0.0335
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0145 0.0145
Echinococcus granulosus beta LACTamase domain containing family member 0.0115 0.0402 0.0673
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0073 0.0073
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0016 0.0016
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0112 0.0388 0.1278
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0001 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1331 0.5365 0.5365
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0158 0.0576 0.0576
Trichomonas vaginalis pyruvate kinase, putative 0.0112 0.0391 0.0391
Trichomonas vaginalis ap endonuclease, putative 0.0082 0.0267 0.0267
Plasmodium falciparum pyruvate kinase 2 0.0058 0.0168 0.429
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.0402 0.0402
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0174 0.0174
Trypanosoma brucei pyruvate kinase 1, putative 0.0112 0.0391 0.1287
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0174 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0099 0.0335 0.0335
Mycobacterium tuberculosis Conserved protein 0.0115 0.0402 0.0582
Loa Loa (eye worm) hypothetical protein 0.0078 0.0252 0.0252
Onchocerca volvulus Pyruvate kinase homolog 0.0112 0.0391 0.0391
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0049 0.0082
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0082 0.0267 0.0267
Brugia malayi pyruvate kinase, muscle isozyme 0.0024 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0045
Brugia malayi Muscleblind-like protein 0.108 0.4341 0.4341
Plasmodium vivax pyruvate kinase 2, putative 0.0058 0.0168 0.4174
Mycobacterium ulcerans pyruvate kinase 0.0112 0.0391 0.0127
Loa Loa (eye worm) pyruvate kinase 0.0112 0.0391 0.0391
Loa Loa (eye worm) nuclear hormone receptor 0.0046 0.0122 0.0122
Loa Loa (eye worm) pyruvate kinase 0.0024 0.0029 0.0029
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0084 0.0274 0.0459
Echinococcus granulosus pyruvate kinase 0.0058 0.0168 0.0281
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0388 0.0388
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0082 0.0267 0.0267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0099 0.0335 0.0335
Echinococcus multilocularis mitogen activated protein kinase 0.0112 0.0388 0.0582
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0001 0.0002
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0082 0.0267 0.0388
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0001 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0475 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0099 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Trypanosoma brucei transcription factor BTF3, putative 0.0073 0.0229 0.0753
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0046 0.0122 0.0205
Brugia malayi photoreceptor-specific nuclear receptor 0.0099 0.0335 0.0335
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0115 0.0402 0.0138
Loa Loa (eye worm) hypothetical protein 0.0046 0.012 0.012
Entamoeba histolytica pyruvate kinase, putative 0.0078 0.0252 0.0252
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0073 0.0242
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.0697 0.1168
Brugia malayi hypothetical protein 0.0773 0.3089 0.3089
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0099 0.0335 0.0561
Brugia malayi nuclear receptor RXR 0.0052 0.0145 0.0145
Onchocerca volvulus 0.0059 0.0174 0.0174
Brugia malayi jmjC domain containing protein 0.0017 0.0001 0.0001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0016 0.0025
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0059 0.0089
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.0361 0.0604
Trypanosoma brucei pyruvate kinase 1 0.0112 0.0391 0.1287
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0361 0.0361
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0024 0.004
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.076 0.3036 0.3036
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0191 0.0286
Leishmania major hypothetical protein, conserved 0.0115 0.0402 0.1323
Echinococcus multilocularis pyruvate kinase 0.0112 0.0391 0.0586
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0402 0.0402
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0073 0.0106
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.0402 0.0673
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0122 0.0205
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0099 0.0335 0.0561
Schistosoma mansoni retinoic acid receptor RXR 0.0099 0.0335 0.0561
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0388 0.0388
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0001 0.0004
Schistosoma mansoni nuclear receptor 0.0046 0.0122 0.0205
Onchocerca volvulus 0.0099 0.0335 0.0335
Brugia malayi beta-lactamase family protein 0.0115 0.0402 0.0402
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.0475 0.1563
Toxoplasma gondii RNA-directed DNA polymerase 0.0065 0.0198 0.4164
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0189 0.0284
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0073 0.0242
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0145 0.0243
Brugia malayi hypothetical protein 0.0046 0.0122 0.0122
Trichomonas vaginalis pyruvate kinase, putative 0.0112 0.0391 0.0391
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0388 0.065
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0135 0.0482 0.0809
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0213 0.0213
Trypanosoma cruzi transcription factor btf3, putative 0.0073 0.0229 0.0753
Treponema pallidum fructose-bisphosphate aldolase 0.1331 0.5365 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0122
Echinococcus granulosus intermediate filament protein 0.0059 0.0174 0.0291
Echinococcus multilocularis mitogen activated protein kinase 3 0.0112 0.0388 0.0582
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0112 0.0388 0.1278
Treponema pallidum exodeoxyribonuclease (exoA) 0.0082 0.0267 0.0498
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0023 0.0023
Brugia malayi conserved hypotetical protein 0.0046 0.0122 0.0122
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0099 0.0335 0.0561
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0046 0.0122 0.0205
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0122
Echinococcus granulosus lamin 0.0059 0.0174 0.0291
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0016 0.0016
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0078 0.0131
Echinococcus granulosus mitogen activated protein kinase 3 0.0112 0.0388 0.065
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0077 0.0254
Onchocerca volvulus 0.0158 0.0576 0.0576
Schistosoma mansoni coup transcription factor 0.0099 0.0335 0.0561
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0001 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0361 0.0361
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0099 0.0335 0.0561
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0082 0.0267 0.0881
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0112 0.0391 0.0566
Brugia malayi hypothetical protein 0.0052 0.0145 0.0145
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1331 0.5365 0.5365
Echinococcus granulosus mitogen activated protein kinase 0.0112 0.0388 0.065
Brugia malayi TAR-binding protein 0.0073 0.0232 0.0232
Brugia malayi hypothetical protein 0.0046 0.0122 0.0122
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0046 0.0122 0.0122
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0898 0.0898
Mycobacterium ulcerans beta-lactamase 0.0115 0.0402 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0099 0.0335 0.0335
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.0475 1
Loa Loa (eye worm) beta-lactamase 0.0115 0.0402 0.0402
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0001 0.0002
Brugia malayi Nuclear hormone receptor E75 0.0046 0.0122 0.0122
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0084 0.0274 0.0411
Brugia malayi Pyruvate kinase, muscle isozyme 0.0112 0.0391 0.0391
Schistosoma mansoni glutaminase 0.0302 0.1166 0.1955
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.065 0.2586 0.375
Schistosoma mansoni transcription factor btf3 0.0073 0.0229 0.0383
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0001 0.0001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0115 0.0402 0.0402
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0046 0.115
Brugia malayi tailless protein 0.0046 0.0122 0.0122
Trichomonas vaginalis glutaminase, putative 0.0302 0.1166 0.1166
Plasmodium vivax pyruvate kinase, putative 0.0112 0.0391 0.9728
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0073 0.011
Loa Loa (eye worm) hypothetical protein 0.0052 0.0145 0.0145
Mycobacterium tuberculosis Probable lipase LipD 0.0115 0.0402 0.0582
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0001 0.0033
Trypanosoma brucei protein kinase, putative 0.0112 0.0388 0.1278
Chlamydia trachomatis pyruvate kinase 0.0112 0.0391 0.5
Entamoeba histolytica hypothetical protein 0.0226 0.0854 0.0854
Brugia malayi nuclear receptor NHR-88 0.0099 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0122
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0001 0.0001
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0001 0.0002
Onchocerca volvulus Pyruvate kinase homolog 0.0112 0.0391 0.0391
Brugia malayi ecdysteroid receptor 0.0099 0.0335 0.0335
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0073 0.0242
Echinococcus granulosus lamin dm0 0.0059 0.0174 0.0291
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0077 0.0254
Loa Loa (eye worm) hypothetical protein 0.0099 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0181 0.067 0.067
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0077 0.0077
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0082 0.0267 0.6657
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0073 0.011
Entamoeba histolytica transcription factor BTF3, putative 0.0073 0.0229 0.0229
Onchocerca volvulus 0.2466 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0082 0.0267 0.0448
Echinococcus multilocularis pyruvate kinase 0.0058 0.0168 0.0251
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.2466 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0264 0.1011 0.1011
Schistosoma mansoni nuclear receptor 0.0046 0.0122 0.0205
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0001 0.0027
Mycobacterium ulcerans hypothetical protein 0.0115 0.0402 0.0138
Brugia malayi nuclear hormone receptor family member nhr-6 0.0046 0.0122 0.0122
Toxoplasma gondii exonuclease III APE 0.0082 0.0267 0.5634
Brugia malayi intermediate filament protein 0.0059 0.0174 0.0174
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0122 0.0183
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0046 0.0122 0.0183
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0122
Echinococcus multilocularis pyruvate kinase 0.0112 0.0391 0.0586
Schistosoma mansoni hypothetical protein 0.0158 0.0576 0.0966
Trypanosoma brucei telomerase reverse transcriptase 0.0065 0.0198 0.0651
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0046 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0181 0.067 0.1122
Loa Loa (eye worm) hypothetical protein 0.0059 0.0174 0.0174
Leishmania major hypothetical protein, conserved 0.0017 0.0001 0.0004
Brugia malayi exodeoxyribonuclease III family protein 0.0082 0.0267 0.0267
Toxoplasma gondii NAC domain-containing protein 0.0073 0.0229 0.4815
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.0361 0.0361
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0059 0.0099
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0122
Echinococcus multilocularis nuclear receptor nhr 48 0.0046 0.0122 0.0183
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0034 0.0071 0.0071
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0122 0.0205
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0073 0.0242
Schistosoma mansoni survival motor neuron protein 0.0158 0.0576 0.0966
Echinococcus granulosus pyruvate kinase 0.0058 0.0168 0.0281
Loa Loa (eye worm) glutaminase 0.0302 0.1166 0.1166
Loa Loa (eye worm) hypothetical protein 0.108 0.4341 0.4341
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.2466 1 1
Toxoplasma gondii pyruvate kinase PyK1 0.0112 0.0391 0.8233
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0099 0.0335 0.0335
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0084 0.0274 0.0459
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.0361 0.1188
Leishmania major hypothetical protein, conserved 0.076 0.3036 1
Brugia malayi Nuclear hormone receptor-like 1 0.0099 0.0335 0.0335
Echinococcus granulosus dnaJ subfamily B 0.0897 0.3596 0.6027
Echinococcus multilocularis ecdysone induced protein 78C 0.0099 0.0335 0.0502
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.0402 0.0673
Echinococcus multilocularis FTZ F1 alpha 0.0099 0.0335 0.0502
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1331 0.5365 0.5365
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0128 0.0215
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0238 0.0903 0.0903
Schistosoma mansoni pyruvate kinase 0.0112 0.0391 0.0655
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1331 0.5365 0.5365
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0038 0.0064
Onchocerca volvulus 0.0046 0.0122 0.0122
Mycobacterium ulcerans glutaminase 0.0302 0.1166 0.0924
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0229 0.0229
Echinococcus granulosus cpg binding protein 0.0068 0.0212 0.0355
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.0475 0.0795
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0099 0.0335 0.0335
Echinococcus multilocularis GPCR, family 2 0.0084 0.0274 0.0411
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0073 0.011
Loa Loa (eye worm) hypothetical protein 0.0052 0.0145 0.0145
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0038 0.0058
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0232 0.0232
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0001 0.0001
Trypanosoma cruzi transcription factor btf3, putative 0.0073 0.0229 0.0753
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0046 0.0973
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.2466 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0046 0.0122 0.0122
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.0361 0.0361
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.2466 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0145 0.0145
Mycobacterium leprae conserved hypothetical protein 0.0115 0.0402 0.005
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0115 0.0402 0.0582
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0082 0.0267 0.0881
Echinococcus granulosus tar DNA binding protein 0.0073 0.0232 0.039
Loa Loa (eye worm) glutaminase 2 0.0302 0.1166 0.1166
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Echinococcus granulosus pyruvate kinase 0.0058 0.0168 0.0281
Brugia malayi nuclear receptor RXR 0.0046 0.0122 0.0122
Echinococcus multilocularis muscleblind protein 0.108 0.4341 0.6513
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0052 0.0145 0.0243
Schistosoma mansoni lamin 0.0059 0.0174 0.0291
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0001 0.0002
Brugia malayi PHD-finger family protein 0.0028 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0052 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0122
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0046 0.0152
Echinococcus multilocularis muscleblind protein 1 0.108 0.4341 0.6513
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0099 0.0335 0.0561
Brugia malayi beta-NAC-like protein 0.0073 0.0229 0.0229
Trypanosoma cruzi hypothetical protein, conserved 0.076 0.3036 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.0697 0.1168
Echinococcus multilocularis musashi 0.0059 0.0174 0.0261
Loa Loa (eye worm) DR-78 0.0046 0.0122 0.0122
Giardia lamblia Kinase, PLK 0.0105 0.0361 0.0361
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0213 0.0357
Leishmania major pyruvate kinase 0.0112 0.0391 0.1287
Loa Loa (eye worm) pyruvate kinase 0.0112 0.0391 0.0391
Schistosoma mansoni zinc finger protein 0.0046 0.0122 0.0205
Schistosoma mansoni ap endonuclease 0.0082 0.0267 0.0448
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0361 0.0604
Loa Loa (eye worm) hypothetical protein 0.0115 0.0402 0.0402
Brugia malayi jmjC domain containing protein 0.0017 0.0001 0.0001
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0077 0.0254
Loa Loa (eye worm) nuclear receptor NHR-67 0.0046 0.0122 0.0122
Brugia malayi Bromodomain containing protein 0.0038 0.0088 0.0088
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0112 0.0388 0.8174
Schistosoma mansoni microtubule-associated protein tau 0.1478 0.5967 1
Echinococcus multilocularis lamin 0.0059 0.0174 0.0261
Schistosoma mansoni nuclear receptor nhr-48 0.0046 0.0122 0.0205
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0115 0.0402 0.0402
Brugia malayi jmjC domain containing protein 0.0017 0.0001 0.0001
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0073 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1331 0.5365 0.5365
Brugia malayi hypothetical protein 0.0226 0.0854 0.0854
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0099 0.0335 0.0335
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0001 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0099 0.0335 0.0502
Schistosoma mansoni thyroid hormone receptor 0.0099 0.0335 0.0561
Loa Loa (eye worm) steroid hormone receptor 0.0099 0.0335 0.0335
Schistosoma mansoni RAR-like nuclear receptor 0.0099 0.0335 0.0561
Giardia lamblia Kinase, CMGC MAPK 0.0112 0.0388 0.0388
Onchocerca volvulus 0.0031 0.0059 0.0059
Trichomonas vaginalis CMGC family protein kinase 0.0112 0.0388 0.0388
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0112 0.0388 0.1278
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.0475 0.0688
Schistosoma mansoni zinc finger protein 0.0023 0.0026 0.0044
Echinococcus granulosus phd:f box containing protein 0.0017 0.0001 0.0002
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0099 0.0335 0.0561
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0112 0.0388 0.1278
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0187 0.0697 0.0697
Mycobacterium leprae Probable lipase LipE 0.0115 0.0402 0.005
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0084 0.0274 0.0459
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0115 0.0402 0.0582
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0082 0.0267 0.5
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0073 0.0242
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.0697 0.1168
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1331 0.5365 0.5365
Brugia malayi Latrophilin receptor protein 2 0.0084 0.0274 0.0274
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0226 0.0854 0.1281
Entamoeba histolytica hypothetical protein 0.0226 0.0854 0.0854
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0232 0.0232
Entamoeba histolytica protein tyrosine phosphatase, putative 0.2466 1 1
Loa Loa (eye worm) ICD-1 protein 0.0073 0.0229 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0099 0.0335 0.0335
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0145 0.0145
Leishmania major pyruvate kinase 0.0112 0.0391 0.1287
Loa Loa (eye worm) hypothetical protein 0.0115 0.0402 0.0402
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.0697 0.1168
Loa Loa (eye worm) latrophilin receptor protein 2 0.0084 0.0274 0.0274
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.0402 0.0402
Echinococcus granulosus FTZ F1 alpha 0.0099 0.0335 0.0561
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0112 0.0388 0.0388
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0232 0.039
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0082 0.0267 0.0267
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.0402 0.1323
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.0697 0.1046
Schistosoma mansoni hypothetical protein 0.0773 0.3088 0.5175
Echinococcus multilocularis beta LACTamase domain containing family member 0.0115 0.0402 0.0603
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.065 0.2586 0.2383
Brugia malayi glutaminase DH11.1 0.0302 0.1166 0.1166
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0146 0.0146
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0073 0.011
Giardia lamblia Pyruvate kinase 0.0112 0.0391 0.0391
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0065 0.0198 0.0651
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.008 0.008
Echinococcus granulosus pyruvate kinase 0.0112 0.0391 0.0655
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0073 0.1828
Schistosoma mansoni lamin 0.0059 0.0174 0.0291
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0232 0.039
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0084 0.0274 0.0459
Brugia malayi beta-lactamase 0.0115 0.0402 0.0402
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0046 0.0122 0.0183
Echinococcus multilocularis expressed protein 0.0036 0.008 0.0121
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0099 0.0335 0.0561
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0052 0.0145 0.0145
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0782 0.0782
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.2466 1 1
Brugia malayi hypothetical protein 0.0052 0.0145 0.0145
Brugia malayi jmjC domain containing protein 0.0069 0.0213 0.0213
Echinococcus granulosus zinc finger protein 0.0023 0.0026 0.0044
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0191 0.0286
Loa Loa (eye worm) hypothetical protein 0.0099 0.0335 0.0335
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.1706 0.6897 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0122
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0073 0.011
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0078 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0099 0.0335 0.0335
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0099 0.0335 0.0561
Plasmodium falciparum pyruvate kinase 0.0112 0.0391 1
Brugia malayi nuclear hormone receptor 0.0046 0.0122 0.0122
Toxoplasma gondii ABC1 family protein 0.0115 0.0402 0.8463
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0046 0.0122 0.0122
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0049 0.0073
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.0361 0.1188
Schistosoma mansoni hypothetical protein 0.0084 0.0274 0.0459
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1331 0.5365 0.5365
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0001 0.0002
Brugia malayi nuclear receptor NHR-67 0.0046 0.0122 0.0122
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.0361 0.0361
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.2466 1 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0073 0.0123
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0099 0.0335 0.0502
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0232 0.0349
Trypanosoma cruzi hypothetical protein, conserved 0.076 0.3036 1
Brugia malayi jmjC domain containing protein 0.0017 0.0001 0.0001
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0062 0.0062
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0049 0.0082
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.2466 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.019 0.019
Brugia malayi Pyruvate kinase, M2 isozyme 0.0112 0.0391 0.0391
Schistosoma mansoni intermediate filament proteins 0.0059 0.0174 0.0291
Echinococcus granulosus thyroid hormone receptor alpha 0.0046 0.0122 0.0205
Schistosoma mansoni transcription factor LCR-F1 0.0226 0.0854 0.143
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0213 0.0357
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.0361 0.0361
Schistosoma mansoni cpg binding protein 0.0068 0.0212 0.0355
Brugia malayi beta-lactamase family protein 0.0115 0.0402 0.0402
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0084 0.0274 0.0459
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.0402 0.1323
Brugia malayi steroid hormone receptor 0.0099 0.0335 0.0335
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0099 0.0335 0.0335
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0122 0.0205
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1331 0.5365 0.5365
Echinococcus multilocularis zinc finger protein 0.0023 0.0026 0.004
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0038 0.0064
Entamoeba histolytica hypothetical protein 0.0226 0.0854 0.0854
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0112 0.0388 0.1278
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0128 0.0215
Echinococcus multilocularis microtubule associated protein 2 0.1478 0.5967 0.8953
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.2466 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0187 0.0697 0.0697
Brugia malayi Telomerase reverse transcriptase 0.0173 0.0638 0.0638
Onchocerca volvulus 0.0115 0.0402 0.0402
Echinococcus multilocularis cpg binding protein 0.0068 0.0212 0.0318
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.0475 0.0712
Echinococcus multilocularis dnaJ subfamily B 0.0897 0.3596 0.5396
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0082 0.0267 0.6843
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0046 0.1182
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0115 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0112 0.0391 0.0391
Echinococcus granulosus Nuclear hormone receptor HR96 0.0046 0.0122 0.0205
Schistosoma mansoni thyroid hormone receptor 0.0099 0.0335 0.0561
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0099 0.0335 0.0561
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0099 0.0335 0.0502
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0361 0.0361
Echinococcus multilocularis geminin 0.0773 0.3088 0.4633
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0073 0.0123
Trypanosoma cruzi pyruvate kinase 2, putative 0.0112 0.0391 0.1287
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0402 0.0402
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0099 0.0335 0.0335
Echinococcus granulosus pyruvate kinase 0.0112 0.0391 0.0655
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0046 0.0122 0.0183
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0232 0.0232
Echinococcus granulosus GPCR family 2 0.0084 0.0274 0.0459
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0115 0.0402 0.0582
Loa Loa (eye worm) hypothetical protein 0.0099 0.0335 0.0335
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0361 0.0361
Brugia malayi Calcitonin receptor-like protein seb-1 0.0264 0.1011 0.1011
Schistosoma mansoni hypothetical protein 0.0773 0.3088 0.5175
Schistosoma mansoni hypothetical protein 0.0226 0.0854 0.143
Loa Loa (eye worm) hypothetical protein 0.0773 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0099 0.0335 0.0335
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0048 0.0128 0.0128
Echinococcus granulosus microtubule associated protein 2 0.1478 0.5967 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0046 0.0122 0.0122
Echinococcus multilocularis thyroid hormone receptor alpha 0.0099 0.0335 0.0502
Toxoplasma gondii histone lysine methyltransferase SET1 0.0123 0.0434 0.9142
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1331 0.5365 0.5365
Echinococcus granulosus transcription factor btf3 0.0073 0.0229 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0229 0.0229
Trichomonas vaginalis ap endonuclease, putative 0.0082 0.0267 0.0267
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0001 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0099 0.0335 0.0502
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0475 0.0213
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0059 0.1243
Onchocerca volvulus 0.0115 0.0402 0.0402
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.2466 1 1
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0232 0.039
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.076 0.3036 0.3036
Echinococcus granulosus Nuclear hormone receptor HR96 0.0046 0.0122 0.0205
Loa Loa (eye worm) hypothetical protein 0.0058 0.017 0.017
Plasmodium vivax JmjC domain containing protein 0.0017 0.0001 0.0032
Entamoeba histolytica hypothetical protein 0.0226 0.0854 0.0854
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0099 0.0335 0.0335
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0099 0.0335 0.0335
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1649 0.6665 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0099 0.0335 0.0335
Brugia malayi MAP kinase sur-1 0.0112 0.0388 0.0388
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0361 0.0361
Brugia malayi RNA binding protein 0.0073 0.0232 0.0232
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0073 0.1547
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0099 0.0335 0.0561
Schistosoma mansoni pyruvate kinase 0.0058 0.0168 0.0281
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0174 0.0174
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0082 0.0267 0.0401
Echinococcus granulosus survival motor neuron protein 1 0.0773 0.3089 0.5177
Plasmodium vivax SET domain protein, putative 0.0031 0.0059 0.1469
Loa Loa (eye worm) hypothetical protein 0.108 0.4341 0.4341
Giardia lamblia Pyruvate kinase 0.0058 0.0168 0.0168
Brugia malayi orphan nuclear receptor NR2E1 0.0046 0.0122 0.0122
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0001 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0361 0.0361
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0046 0.0122 0.0205
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0402 0.0402
Mycobacterium tuberculosis Probable hydrolase 0.0115 0.0402 0.0582
Brugia malayi latrophilin 2 splice variant baaae 0.0181 0.067 0.067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.0697 0.1046
Schistosoma mansoni cpg binding protein 0.0063 0.019 0.0318
Loa Loa (eye worm) hypothetical protein 0.0264 0.1011 0.1011
Brugia malayi hypothetical protein 0.0018 0.0006 0.0006
Trichomonas vaginalis rotamase, putative 0.0036 0.008 0.008
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.007 0.0219 0.0219
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0001 0.0002
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0065 0.0198 0.0651
Brugia malayi nuclear hormone receptor 0.0099 0.0335 0.0335
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0077 0.1623
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.008 0.008
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.0361 0.0541
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0112 0.0388 0.1278
Brugia malayi pyruvate kinase 0.0024 0.0029 0.0029
Brugia malayi isocitrate dehydrogenase 0.0035 0.0073 0.0073
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0062 0.0062
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0073 0.1547
Brugia malayi Pre-SET motif family protein 0.0031 0.0059 0.0059
Echinococcus granulosus expressed protein 0.0036 0.008 0.0135
Schistosoma mansoni bromodomain containing protein 0.0066 0.0204 0.0341
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0099 0.0335 0.0502
Schistosoma mansoni nuclear hormone receptor 0.0099 0.0335 0.0561
Loa Loa (eye worm) pyruvate kinase-PB 0.0078 0.0252 0.0252
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0232 0.039
Plasmodium vivax telomerase reverse transcriptase, putative 0.0065 0.0198 0.4921
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0045
Schistosoma mansoni cpg binding protein 0.0068 0.0212 0.0355

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.4 uM Antagonist activity at P2Y12 receptor in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation by light transmission aggregometry ChEMBL. 19796941
Ki (binding) = 2.7 nM Binding affinity at human recombinant P2Y12 receptor expressed in CHO cells by radioligand binding assay ChEMBL. 19796941
Ratio IC50 (binding) = 0.3 Ratio of compound IC50 to thienopyrimidine IC50 for P2Y12 receptor in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation by light transmission aggregometry ChEMBL. 19796941
Ratio IC50 (binding) = 1.3 Ratio of compound IC50 to AZD-6140 IC50 for P2Y12 receptor in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation by light transmission aggregometry ChEMBL. 19796941

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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