TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 443.498 | Formula: C25H25N5O3
H donors: 5 H acceptors: 3 LogP: 1.54 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(cc1)C(=O)N)NCc1cccc(c1)C(=O)Nc1ccc2c(c1)CNCC2
InChi: 1S/C25H25N5O3/c26-23(31)18-5-7-21(8-6-18)30-25(33)28-14-16-2-1-3-19(12-16)24(32)29-22-9-4-17-10-11-27-15-20(17)13-22/h1-9,12-13,27H,10-11,14-15H2,(H2,26,31)(H,29,32)(H2,28,30,33)
InChiKey: SCIFUGGHOXNSJC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cell division cycle 42	Starlite/ChEMBL	References
Homo sapiens	Rho-associated, coiled-coil containing protein kinase 2	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, epsilon	Starlite/ChEMBL	References
Homo sapiens	protein kinase N2	Starlite/ChEMBL	References
Homo sapiens	protein kinase, cGMP-dependent, type I	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	cGMP dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	Serine/threonine-protein kinase N2, putative	Get druggable targets OG5_130229	All targets in OG5_130229
Schistosoma japonicum	cGMP-dependent protein kinase 2, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium knowlesi	cGMP-dependent protein kinase, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	rho associated protein kinase	Get druggable targets OG5_131020	All targets in OG5_131020
Cryptosporidium parvum	cyclic nucleotide (cGMP)-dependent protein kinase with 3 cNMP binding domains and a Ser/Thr kinase domain	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma mansoni	cell polarity protein	Get druggable targets OG5_129885	All targets in OG5_129885
Echinococcus granulosus	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	protein kinase c epsilon type	Get druggable targets OG5_129314	All targets in OG5_129314
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	Get druggable targets OG5_127599	All targets in OG5_127599
Candida albicans	one of two genes similar to S. cerevisiae CDC42 (YLR229C) rho family small monomeric GTPase	Get druggable targets OG5_129885	All targets in OG5_129885
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_131020	All targets in OG5_131020
Loa Loa (eye worm)	GTP-binding protein	Get druggable targets OG5_129885	All targets in OG5_129885
Echinococcus granulosus	ras gtpase	Get druggable targets OG5_129885	All targets in OG5_129885
Loa Loa (eye worm)	AGC/PKN protein kinase	Get druggable targets OG5_130229	All targets in OG5_130229
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_127599	All targets in OG5_127599
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma japonicum	ko:K07376 protein kinase, cGMP-dependent, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium falciparum	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	expressed protein	Get druggable targets OG5_130229	All targets in OG5_130229
Schistosoma japonicum	IPR000961,Protein kinase, C-terminal,domain-containing	Get druggable targets OG5_130229	All targets in OG5_130229
Echinococcus multilocularis	serine:threonine protein kinase N2	Get druggable targets OG5_130229	All targets in OG5_130229
Schistosoma mansoni	cell polarity protein	Get druggable targets OG5_129885	All targets in OG5_129885
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus multilocularis	serine:threonine protein kinase N2	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus granulosus	serine:threonine protein kinase N2	Get druggable targets OG5_130229	All targets in OG5_130229
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	Get druggable targets OG5_131020	All targets in OG5_131020
Schistosoma japonicum	Rho-associated protein kinase 1, putative	Get druggable targets OG5_131020	All targets in OG5_131020
Theileria parva	cGMP-dependent protein kinase, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Onchocerca volvulus		Get druggable targets OG5_131020	All targets in OG5_131020
Echinococcus granulosus	serine:threonine protein kinase N2	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma japonicum	ko:K06068 novel protein kinase C, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Plasmodium berghei	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Plasmodium yoelii	cGMP-dependent protein kinase-related	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	serine:threonine protein kinase N2	Get druggable targets OG5_130229	All targets in OG5_130229
Schistosoma japonicum	Cell division control protein 42 homolog precursor, putative	Get druggable targets OG5_129885	All targets in OG5_129885
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_130229	All targets in OG5_130229
Schistosoma japonicum	ko:K07376 protein kinase, cGMP-dependent, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	protein kinase c epsilon type	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma japonicum	cGMP-dependent protein kinase, isozyme 1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing	Get druggable targets OG5_131020	All targets in OG5_131020
Echinococcus multilocularis	serine:threonine protein kinase N2	Get druggable targets OG5_130229	All targets in OG5_130229
Brugia malayi	GTP-binding protein, identical	Get druggable targets OG5_129885	All targets in OG5_129885
Neospora caninum	AGC kinase TgPKG1, putative	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	Cdc42 homolog precursor, putative	Get druggable targets OG5_129885	All targets in OG5_129885
Loa Loa (eye worm)	AGC/PKG protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	cGMP dependent protein kinase 1	Get druggable targets OG5_127599	All targets in OG5_127599
Brugia malayi	GTP-binding protein	Get druggable targets OG5_129885	All targets in OG5_129885
Brugia malayi	Egg laying defective protein 4	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus multilocularis	ras gtpase	Get druggable targets OG5_129885	All targets in OG5_129885
Babesia bovis	cGMP dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Schistosoma japonicum	Protein kinase C epsilon type, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Brugia malayi	protein kinase C II.	Get druggable targets OG5_129314	All targets in OG5_129314
Candida albicans	one of two genes similar to S. cerevisiae CDC42 (YLR229C) rho family small monomeric GTPase	Get druggable targets OG5_129885	All targets in OG5_129885
Brugia malayi	Hr1 repeat family protein	Get druggable targets OG5_130229	All targets in OG5_130229
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_131020	All targets in OG5_131020
Cryptosporidium hominis	cGMP-dependent protein kinase	Get druggable targets OG5_127599	All targets in OG5_127599
Echinococcus granulosus	rho-associated protein kinase 1	Get druggable targets OG5_131020	All targets in OG5_131020
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127599	All targets in OG5_127599
Onchocerca volvulus		Get druggable targets OG5_131020	All targets in OG5_131020
Schistosoma japonicum	Serine/threonine-protein kinase N1, putative	Get druggable targets OG5_130229	All targets in OG5_130229
Echinococcus multilocularis	expressed conserved protein	Get druggable targets OG5_127599	All targets in OG5_127599

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	ras-related protein Rab-5B	cell division cycle 42	191 aa	171 aa	23.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0028	0.0039
Schistosoma mansoni	hypothetical protein	0.0032	0.031	0.031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0127	0.0355
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0555	0.0555
Onchocerca volvulus		0.0258	0.3385	0.5309
Brugia malayi	AMP-binding enzyme family protein	0.0015	0.0085	0.0106
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0051	0.0578	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0694	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0028	0.0029
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0028	0.0044
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.001	0.0021	0.0026
Trichomonas vaginalis	antibiotic synthetase, putative	0.0015	0.0085	0.023
Plasmodium vivax	SET domain protein, putative	0.0033	0.033	0.8186
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0015	0.0085	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0046	0.0062
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0012	0.0046	0.0052
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0127	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0401	0.0548
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0015	0.0085	0.0116
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0127	0.0355
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0046	0.0062
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0015	0.0085	0.0085
Echinococcus multilocularis	serine:threonine protein kinase N2	0.018	0.2322	0.2322
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0104	0.1289	0.1289
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0611	0.0835
Plasmodium vivax	hypothetical protein, conserved	0.0012	0.0046	0.099
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0301	0.0402
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0015	0.0085	0.0952
Echinococcus multilocularis	lysine specific demethylase 5A	0.0038	0.0401	0.0401
Onchocerca volvulus		0.0015	0.0085	0.0133
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0127	0.0127
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0001	0.0001
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0023	0.0189	0.0538
Echinococcus granulosus	cathepsin L cysteine protease	0.0009	0.0007	0.0007
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0046	0.0052
Brugia malayi	AMP-binding enzyme family protein	0.0051	0.0578	0.078
Brugia malayi	Protein kinase domain containing protein	0.0547	0.7318	1
Onchocerca volvulus		0.0015	0.0085	0.0133
Echinococcus multilocularis	lysine specific demethylase 6a	0.001	0.0019	0.0019
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0111	0.0142
Leishmania major	cathepsin L-like protease	0.0018	0.0127	0.1348
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0127	0.0355
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0028	0.0028
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.031	0.7691
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0822	1
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0028	0.0028
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0028	0.0028
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.031	0.4315
Onchocerca volvulus		0.0015	0.0085	0.0133
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0127	0.0164
Leishmania major	4-coumarate:coa ligase-like protein	0.0051	0.0578	0.6961
Plasmodium vivax	vivapain-2	0.0018	0.0127	0.3041
Echinococcus multilocularis	protein kinase c epsilon type	0.0116	0.1458	0.1458
Echinococcus multilocularis	expressed conserved protein	0.0046	0.0502	0.0502
Toxoplasma gondii	PHD-finger domain-containing protein	0.001	0.0021	0.0026
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0001	0.0001
Echinococcus granulosus	PHD finger protein rhinoceros	0.0032	0.031	0.031
Echinococcus multilocularis	ras gtpase	0.0168	0.2169	0.2169
Trichomonas vaginalis	antibiotic synthetase, putative	0.0015	0.0085	0.023
Onchocerca volvulus		0.0012	0.0046	0.0071
Brugia malayi	p70 ribosomal S6 kinase beta	0.0024	0.0205	0.027
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0028	0.0029
Echinococcus granulosus	protein kinase c iota type	0.0031	0.0304	0.0304
Echinococcus granulosus	rho-associated protein kinase 1	0.0177	0.2281	0.2281
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0555	0.0759
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0046	0.0052
Schistosoma mansoni	atypical protein kinase C	0.0031	0.0304	0.0304
Plasmodium falciparum	cGMP-dependent protein kinase	0.0046	0.0502	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.038	0.0519
Trichomonas vaginalis	AGC family protein kinase	0.0024	0.0205	0.0584
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0015	0.0085	0.0977
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0015	0.0085	0.0822
Brugia malayi	jmjC domain containing protein	0.001	0.0019	0.0016
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.0085	0.0546
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0028	0.0028
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0028	0.0039
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0555	0.0749
Trichomonas vaginalis	AGC family protein kinase	0.0024	0.0205	0.0584
Plasmodium falciparum	phd finger protein, putative	0.0032	0.031	0.6121
Loa Loa (eye worm)	thyroid receptor interactor	0.0086	0.1052	0.1438
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0127	0.0355
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0822	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0028	0.0039
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0046	0.0063
Schistosoma mansoni	hypothetical protein	0.0052	0.0587	0.0587
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0028	0.0028
Brugia malayi	GTP-binding protein, identical	0.0168	0.2169	0.2957
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0822	1
Schistosoma mansoni	serine/threonine protein kinase	0.018	0.2322	0.2322
Onchocerca volvulus		0.0031	0.0301	0.0473
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0028	0.0028
Brugia malayi	hypothetical protein	0.0255	0.3348	0.457
Entamoeba histolytica	protein kinase, putative	0.0024	0.0205	0.0325
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0555	0.0555
Echinococcus granulosus	serine:threonine protein kinase N2	0.0156	0.1997	0.1997
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0127	0.0355
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.033	0.033
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0051	0.0578	0.0938
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0227	0.2961	0.4046
Leishmania major	cathepsin L-like protease	0.0018	0.0127	0.1348
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0028	0.0039
Brugia malayi	nuclear hormone receptor	0.0011	0.0028	0.0029
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0046	0.0502	0.0686
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0127	0.0355
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0127	0.0164
Brugia malayi	hypothetical protein	0.0478	0.6376	0.8711
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0611	0.0835
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0127	0.0355
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0127	0.1472
Schistosoma mansoni	phosphatidylserine receptor	0.001	0.0019	0.0019
Brugia malayi	Bromodomain containing protein	0.0032	0.031	0.0414
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0028	0.0028
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0822	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0028	0.0044
Schistosoma mansoni	hypothetical protein	0.0037	0.038	0.038
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0007	0.0007
Brugia malayi	Pre-SET motif family protein	0.0033	0.033	0.0441
Loa Loa (eye worm)	cysteine protease	0.0018	0.0127	0.0174
Brugia malayi	GTP-binding protein	0.0168	0.2169	0.2957
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0127	0.0164
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0028	0.0029
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0028	0.0029
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.062	0.7525
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0127	0.0355
Echinococcus multilocularis	dnaJ subfamily B	0.0441	0.5878	0.5878
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0587	0.0793
Trichomonas vaginalis	AGC family protein kinase	0.0024	0.0205	0.0584
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0611	0.0826
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0007	0.0007
Brugia malayi	jmjC domain containing protein	0.0104	0.1289	0.1754
Brugia malayi	steroid hormone receptor	0.0011	0.0028	0.0029
Brugia malayi	cathepsin L-like precursor	0.0012	0.0046	0.0052
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0502	0.0502
Brugia malayi	jmjC domain containing protein	0.001	0.0019	0.0016
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0822	1
Leishmania major	cathepsin L-like protease	0.0069	0.0822	1
Echinococcus granulosus	NDR protein kinase	0.0024	0.0205	0.0205
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0018	0.0127	0.0127
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0127	0.0127
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0205	0.027
Plasmodium falciparum	JmjC domain-containing protein, putative	0.001	0.0019	0.0234
Echinococcus granulosus	survival motor neuron protein 1	0.0255	0.3348	0.3348
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0015	0.0085	0.0546
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0046	0.0502	0.7158
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0822	1
Entamoeba histolytica	protein kinase, putative	0.0024	0.0205	0.0325
Schistosoma mansoni	phd/f-box containing protein	0.001	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0401	0.0548
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0618	0.0844
Loa Loa (eye worm)	fibroinase	0.0018	0.0127	0.0174
Trypanosoma cruzi	cruzipain precursor, putative	0.0069	0.0822	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.033	0.4604
Brugia malayi	AMP-binding enzyme family protein	0.0051	0.0578	0.078
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0107	0.1338	0.1338
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0028	0.0028
Echinococcus granulosus	protein kinase C gamma type	0.0025	0.0225	0.0225
Echinococcus granulosus	jumonji domain containing 1A	0.001	0.0019	0.0019
Onchocerca volvulus		0.0051	0.0578	0.0906
Schistosoma mansoni	cell polarity protein	0.0168	0.2169	0.2169
Onchocerca volvulus		0.0018	0.0127	0.02
Entamoeba histolytica	hypothetical protein	0.0456	0.6087	1
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0028	0.0044
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.001	0.0019	0.0142
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0046	0.0113
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0822	1
Plasmodium falciparum	acyl-CoA synthetase	0.0038	0.0401	0.796
Plasmodium vivax	JmjC domain containing protein	0.001	0.0019	0.0294
Schistosoma mansoni	cpg binding protein	0.0033	0.0325	0.0325
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0007	0.0007
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0205	0.027
Schistosoma mansoni	serine/threonine kinase	0.0024	0.0205	0.0205
Echinococcus granulosus	serine:threonine protein kinase N2	0.018	0.2322	0.2322
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.001	0.0019	0.0142
Leishmania major	cathepsin L-like protease	0.0069	0.0822	1
Schistosoma mansoni	hypothetical protein	0.0441	0.5878	0.5878
Loa Loa (eye worm)	jmjC domain-containing protein	0.001	0.0019	0.0026
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0015	0.0085	0.0952
Echinococcus granulosus	cysteine protease	0.0009	0.0007	0.0007
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0024	0.0205	0.0205
Toxoplasma gondii	cathepsin CPL	0.0018	0.0127	0.1603
Brugia malayi	Egg laying defective protein 4	0.0046	0.0502	0.0677
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0051	0.0578	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0127	0.0355
Schistosoma mansoni	lozenge	0.006	0.0695	0.0695
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0822	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.033	0.033
Echinococcus granulosus	lysine specific demethylase 5A	0.004	0.0425	0.0425
Leishmania major	cathepsin L-like protease	0.0018	0.0127	0.1348
Loa Loa (eye worm)	hypothetical protein	0.0255	0.3348	0.4575
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0301	0.0412
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0024	0.0205	0.028
Echinococcus multilocularis	peregrin	0.0032	0.031	0.031
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0028	0.0029
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0018	0.0127	0.2421
Echinococcus granulosus	serine:threonine protein kinase N2	0.0084	0.1029	0.1029
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0039
Mycobacterium ulcerans	hypothetical protein	0.0051	0.0578	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0028	0.0028
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0028	0.0028
Entamoeba histolytica	protein kinase, putative	0.0024	0.0205	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0578	0.0789
Schistosoma mansoni	hypothetical protein	0.0017	0.0111	0.0111
Mycobacterium ulcerans	acyl-CoA synthetase	0.0051	0.0578	1
Brugia malayi	AMP-binding enzyme family protein	0.0015	0.0085	0.0106
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0024	0.0205	0.028
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0205	0.028
Loa Loa (eye worm)	runx1	0.006	0.0695	0.095
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0028	0.0028
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0127	0.0355
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0555	0.0555
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.0085	0.0546
Trichomonas vaginalis	AGC family protein kinase	0.0024	0.0205	0.0584
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0028	0.0029
Echinococcus multilocularis	cpg binding protein	0.0033	0.0325	0.0325
Onchocerca volvulus		0.0175	0.2266	0.3554
Echinococcus granulosus	cathepsin l1	0.0018	0.0127	0.0127
Echinococcus multilocularis	cathepsin L	0.0009	0.0007	0.0007
Trichomonas vaginalis	AGC family protein kinase	0.0024	0.0205	0.0584
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.1631	0.2229
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0086	0.1052	0.1429
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0304	0.0304
Onchocerca volvulus		0.0052	0.0587	0.0921
Echinococcus multilocularis	serine threonine protein kinase	0.0025	0.0225	0.0225
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0127	0.0355
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.079	0.079
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0015	0.0085	0.0546
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0111	0.0142
Brugia malayi	jmjC domain containing protein	0.001	0.0019	0.0016
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.033	0.033
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0028	0.0039
Onchocerca volvulus	Alhambra homolog	0.0032	0.031	0.0487
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0012	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0578	0.0789
Brugia malayi	MH2 domain containing protein	0.0129	0.1631	0.2221
Loa Loa (eye worm)	hypothetical protein	0.0033	0.033	0.0451
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.001	0.0021	0.0164
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0001	0.0001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0127	0.0355
Echinococcus multilocularis	phd:f box containing protein	0.001	0.0019	0.0019
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0084	0.1029	0.168
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0028	0.0029
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0822	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0611	0.0826
Loa Loa (eye worm)	jmjC domain-containing protein	0.0065	0.0768	0.105
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0085	0.0116
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0028	0.0029
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.033	0.033
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0046	0.0502	0.0502
Loa Loa (eye worm)	jmjC domain-containing protein	0.004	0.0425	0.0581
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0127	0.0355
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0028	0.0028
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0127	0.0127
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0028	0.0029
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0015	0.0085	0.0128
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0325	0.0325
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0028	0.0039
Brugia malayi	jmjC domain containing protein	0.001	0.0019	0.0016
Plasmodium vivax	acyl-CoA synthetase, putative	0.0038	0.0401	1
Giardia lamblia	PHD finger protein 15	0.0032	0.031	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0039
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0127	0.0127
Echinococcus multilocularis	protein kinase c iota type	0.0031	0.0304	0.0304
Echinococcus multilocularis	Protein lozenge	0.006	0.0695	0.0695
Schistosoma mansoni	jumonji domain containing protein	0.0082	0.1	0.1
Onchocerca volvulus		0.0011	0.0028	0.0044
Echinococcus granulosus	cathepsin L	0.0009	0.0007	0.0007
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0015	0.0085	0.0085
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.001	0.0019	0.0142
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.0046	0.0046
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0015	0.0085	0.0952
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0001	0.0001
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.033	0.033
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0028	0.0028
Brugia malayi	PHD-finger family protein	0.0032	0.031	0.0414
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0018	0.0127	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0401	0.0548
Onchocerca volvulus		0.0033	0.033	0.0517
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0018	0.0127	0.0127
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0373	0.6071
Mycobacterium ulcerans	hypothetical protein	0.0045	0.0487	0.8153
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0046	0.0502	0.0502
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0024	0.0205	0.028
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0028	0.0028
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0028	0.0028
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0127	0.0164
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0028	0.0028
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0015	0.0085	0.0977
Brugia malayi	Hr1 repeat family protein	0.018	0.2322	0.3166
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0018	0.0127	0.2421
Entamoeba histolytica	protein kinase, putative	0.0024	0.0205	0.0325
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0028	0.0028
Echinococcus granulosus	dnaJ subfamily B	0.0441	0.5878	0.5878
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0587	0.0587
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.0205	0.0205
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0127	0.0355
Echinococcus granulosus	cGMP dependent protein kinase	0.0046	0.0502	0.0502
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.1631	0.2229
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0051	0.0578	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0028	0.0028
Onchocerca volvulus		0.0015	0.0085	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0111	0.0152
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0015	0.0085	0.0546
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0822	1
Schistosoma mansoni	acetyl-CoA synthetase	0.0015	0.0085	0.0085
Echinococcus granulosus	jumonji domain containing protein	0.0044	0.0479	0.0479
Leishmania major	acetyl-CoA synthetase, putative	0.0015	0.0085	0.0822
Loa Loa (eye worm)	jmjC domain-containing protein	0.001	0.0019	0.0026
Brugia malayi	AF-10 protein	0.001	0.0021	0.0018
Loa Loa (eye worm)	GTP-binding protein	0.0168	0.2169	0.2964
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0028	0.0028
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0028	0.0028
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0038	0.0401	0.6617
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0111	0.0111
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0111	0.0111
Toxoplasma gondii	propionate-CoA ligase	0.0015	0.0085	0.0977
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0027	0.0027
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0019	0.0142	0.0142
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0127	0.0355
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0116	0.1458	0.1992
Onchocerca volvulus		0.0018	0.0127	0.02
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0012	0.0043	0.0043
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0028	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0578	0.0789
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0028	0.0029
Schistosoma mansoni	cpg binding protein	0.0031	0.0301	0.0301
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0027	0.0036
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.0205	0.0205
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0015	0.0085	0.1566
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0127	0.02
Onchocerca volvulus		0.0018	0.0127	0.02
Leishmania major	cathepsin L-like protease	0.0018	0.0127	0.1348
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0111	0.0152
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0024	0.0205	0.0205
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0015	0.0085	0.1968
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0127	0.0355
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0046	0.0113
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.0085	0.0546
Leishmania major	cathepsin L-like protease	0.0018	0.0127	0.1348
Loa Loa (eye worm)	jmjC domain-containing protein	0.001	0.0019	0.0026
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0028	0.0039
Echinococcus granulosus	phd:f box containing protein	0.001	0.0019	0.0019
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0028	0.0028
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0028	0.0028
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0028	0.0028
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0127	0.0164
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0015	0.0085	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0039
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0015	0.0085	0.0546
Mycobacterium ulcerans	acyl-CoA synthetase	0.0051	0.0578	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0373	0.6071
Echinococcus granulosus	peregrin	0.0032	0.031	0.031
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.031	0.4315
Onchocerca volvulus		0.0018	0.0127	0.02
Echinococcus multilocularis	survival motor neuron protein 1	0.0255	0.3348	0.3348
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0325	0.0325
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0024	0.0205	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0085	0.0116
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0127	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0127	0.0174
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0028	0.0029
Trichomonas vaginalis	AGC family protein kinase	0.0024	0.0205	0.0584
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0032	0.031	0.031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0127	0.0355
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.0425	0.0425
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0028	0.0028
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0085	0.0106
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0051	0.0578	1
Onchocerca volvulus		0.0177	0.2281	0.3578
Echinococcus granulosus	protein kinase c epsilon type	0.0116	0.1458	0.1458
Leishmania major	cysteine peptidase A (CPA)	0.0018	0.0127	0.1348
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0046	0.0062
Mycobacterium ulcerans	acyl-CoA synthetase	0.0051	0.0578	1
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0028	0.0028
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	0.0547	0.7318	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0028	0.0029
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0038	0.0401	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0555	0.0555
Brugia malayi	AMP-binding enzyme family protein	0.0051	0.0578	0.078
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0127	0.0355
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0127	0.0197
Schistosoma mansoni	hypothetical protein	0.001	0.0021	0.0021
Schistosoma mansoni	jumonji domain containing protein	0.001	0.0019	0.0019
Schistosoma mansoni	serine/threonine protein kinase	0.0116	0.1458	0.1458
Loa Loa (eye worm)	hypothetical protein	0.0032	0.031	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0039
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0015	0.0085	0.0116
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0373	0.6071
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0039
Entamoeba histolytica	acyl-coA synthetase, putative	0.0051	0.0578	0.0938
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0127	0.0127
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0028	0.0028
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.001	0.0019	0.0019
Schistosoma mansoni	cpg binding protein	0.0033	0.0325	0.0325
Loa Loa (eye worm)	AGC/PKN protein kinase	0.018	0.2322	0.3173
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0028	0.0039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0127	0.0355
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.033	0.033
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0127	0.02
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0051	0.0578	0.0938
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0127	0.0355
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0015	0.0085	0.0546
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0027	0.0027
Trichomonas vaginalis	AGC family protein kinase	0.0024	0.0205	0.0584
Onchocerca volvulus		0.0018	0.0127	0.02
Schistosoma mansoni	protein phosphatase 2C	0.001	0.0019	0.0019
Schistosoma mansoni	serine/threonine protein kinase	0.0024	0.0205	0.0205
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0033	0.0325	0.0325
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0015	0.0085	0.0952
Leishmania major	4-coumarate:coa ligase-like protein	0.0051	0.0578	0.6961
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0038	0.0401	0.6421
Echinococcus granulosus	JmjC domain containing protein 4	0.001	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0039
Leishmania major	4-coumarate:coa ligase-like protein	0.0051	0.0578	0.6961
Onchocerca volvulus		0.0018	0.0127	0.02
Brugia malayi	F/Y-rich N-terminus family protein	0.0021	0.0166	0.0216
Schistosoma mansoni	hypothetical protein	0.0017	0.0111	0.0111
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0205	0.027
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0028	0.0028
Echinococcus granulosus	ras gtpase	0.0168	0.2169	0.2169
Echinococcus multilocularis	jumonji domain containing 1A	0.001	0.0019	0.0019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0127	0.0355
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0046	0.0502	0.0502
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0024	0.0205	0.028
Onchocerca volvulus		0.0478	0.6376	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0127	0.0127
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0555	0.0555
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0111	0.0111
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.0425	0.0425
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0015	0.0085	0.0952
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0822	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0111	0.0111
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0024	0.0205	0.0205
Echinococcus granulosus	Protein kinase C brain isozyme	0.0033	0.0325	0.0325
Trichomonas vaginalis	AGC family protein kinase	0.0024	0.0205	0.0584
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.033	0.033
Loa Loa (eye worm)	PHD-finger family protein	0.0032	0.031	0.0424
Schistosoma mansoni	hypothetical protein	0.0017	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0478	0.6376	0.8713
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0012	0.0046	0.0788
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.038	0.051
Plasmodium vivax	vivapain-2	0.0018	0.0127	0.3041
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0127	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0045	0.0061
Toxoplasma gondii	AGC kinase	0.0024	0.0205	0.2752
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0015	0.0085	0.0952
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0028	0.0029
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0104	0.1289	0.1289
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0015	0.0085	0.0546
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0024	0.0205	0.028
Onchocerca volvulus	Cathepsin F homolog	0.0018	0.0127	0.02
Echinococcus granulosus	lysine specific demethylase 6a	0.001	0.0019	0.0019
Leishmania major	cathepsin L-like protease	0.0069	0.0822	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0127	0.0355
Leishmania major	acetyl-CoA synthetase, putative	0.0015	0.0085	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0478	0.6376	0.8713
Loa Loa (eye worm)	oxidoreductase	0.0015	0.0085	0.0116
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0063	0.074	0.8997
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0018	0.0127	0.2421
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0401	0.0548
Echinococcus multilocularis	rho associated protein kinase	0.0177	0.2281	0.2281
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0028	0.0029
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0127	0.0197
Schistosoma mansoni	coup transcription factor	0.0011	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0039
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0555	0.0555
Echinococcus granulosus	cathepsin l1	0.0012	0.0046	0.0046
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0015	0.0085	0.0546
Onchocerca volvulus		0.0018	0.0127	0.02
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0024	0.0205	0.2425
Echinococcus multilocularis	cysteine protease	0.0018	0.0127	0.0127
Brugia malayi	AMP-binding enzyme family protein	0.0015	0.0085	0.0106
Echinococcus multilocularis	cysteine protease	0.0018	0.0127	0.0127
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0822	1
Echinococcus multilocularis	JmjC domain containing protein 4	0.001	0.0019	0.0019
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0127	0.0355
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0032	0.031	0.031
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0156	0.1997	0.1997
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0822	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0051	0.0578	1
Brugia malayi	protein kinase C II.	0.0116	0.1458	0.1984
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0822	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0578	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0051	0.0578	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0373	0.6071
Trichomonas vaginalis	AGC family protein kinase	0.0024	0.0205	0.0584
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0024	0.0205	0.0205
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0127	0.0355
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0127	0.0355
Brugia malayi	AMP-binding enzyme family protein	0.0015	0.0085	0.0106
Brugia malayi	ecdysteroid receptor	0.0011	0.0028	0.0029
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0024	0.0205	0.0205
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0046	0.0502	0.0502
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0555	0.0555
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0028	0.0029
Trichomonas vaginalis	set domain proteins, putative	0.0258	0.3385	1
Schistosoma mansoni	cell polarity protein	0.0168	0.2169	0.2169
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0028	0.0028
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0051	0.0578	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0026
Trichomonas vaginalis	AGC family protein kinase	0.0024	0.0205	0.0584
Schistosoma mansoni	microtubule-associated protein tau	0.0744	1	1
Brugia malayi	Protein kinase c protein 2	0.001	0.0016	0.0011
Echinococcus multilocularis	microtubule associated protein 2	0.0744	1	1
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0111	0.0111
Loa Loa (eye worm)	ctsf protein	0.0018	0.0127	0.0174
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0024	0.0205	0.028
Echinococcus granulosus	cpg binding protein	0.0033	0.0325	0.0325
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0028	0.0029
Brugia malayi	PHD-finger family protein	0.0012	0.0045	0.0051
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.001	0.0021	0.0164
Trichomonas vaginalis	AGC family protein kinase	0.0024	0.0205	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0401	0.0548
Echinococcus granulosus	GPCR family 2	0.0017	0.0111	0.0111
Echinococcus multilocularis	jumonji domain containing protein	0.0044	0.0479	0.0479
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0127	0.0174
Brugia malayi	jmjC domain containing protein	0.004	0.0425	0.0571
Brugia malayi	Pre-SET motif family protein	0.0227	0.2961	0.404
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0502	0.0502
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0026
Schistosoma mansoni	serine/threonine protein kinase	0.0177	0.2281	0.2281
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0039
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0111	0.0111
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0024	0.0205	0.0205

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4 nM	Inhibition of human ROCK2 by homogenous luciferase assay	ChEMBL.	20000469
IC50 (binding)	= 770 nM	Inhibition of PKN2	ChEMBL.	20000469
IC50 (binding)	= 3000 nM	Inhibition of PKCepsilon	ChEMBL.	20000469
IC50 (binding)	= 3000 nM	Inhibition of PRKG1	ChEMBL.	20000469
IC50 (binding)	> 5000 nM	Inhibition of Cdc42	ChEMBL.	20000469
Inhibition (binding)	= 33 %	Inhibition of PRK2	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of Aurora B at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of CAMK1 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of CDK2 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of CHK1 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of CHK2 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of CK1 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of CSK at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of DYRK1A at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of EF2K at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of ERK8 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of GSK3-beta at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of MAPK2 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of MAPKAPK1A at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of MAPKAPK1b at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of MAPKAPK2 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of MAPKAPK3 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of MARK3 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of MKK1 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of MNK1 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of MNK2 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of MSK1 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of MST2 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of NEK6 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of NEK7 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of PBK at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of PDK1 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of PIM2 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of PKBbeta at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of PKD1 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of PLK1 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of PRAK at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of S6K1 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of SGK at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of SMMLCK at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of SRC at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of SRPK1 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	= 50 %	Inhibition of PKCalpha	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of NEK2a at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of JNK3a1 at 3 uM relative to control	ChEMBL.	20000469
Inhibition (binding)	> 50 %	Inhibition of JNK1a1 at 3 uM relative to control	ChEMBL.	20000469

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL600852

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1096109