Detailed information for compound 110546

Basic information

Technical information
  • TDR Targets ID: 110546
  • Name: 5-fluoro-3-thiophen-3-ylquinoline
  • MW: 229.273 | Formula: C13H8FNS
  • H donors: 0 H acceptors: 1 LogP: 3.6 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc2c1cc(cn2)c1ccsc1
  • InChi: 1S/C13H8FNS/c14-12-2-1-3-13-11(12)6-10(7-15-13)9-4-5-16-8-9/h1-8H
  • InChiKey: BEVNNTNJJJWQAK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-fluoro-3-(3-thienyl)quinoline
  • 5-fluoro-3-thiophen-3-yl-quinoline

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens platelet-derived growth factor receptor, alpha polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0033 0.0079 0.0847
Brugia malayi ABC transporter transmembrane region family protein 0.0031 0.0074 0.0334
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0033 0.0079 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0033 0.0079 0.0235
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0104 0.0419 0.6071
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0038 0.0173
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0033 0.0079 0.5
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0046 0.0144 0.0487
Schistosoma mansoni biogenic amine receptor 0.0024 0.0038 0.0058
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0038 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0038 0.0058
Entamoeba histolytica P-glycoprotein-1 0.0104 0.0419 0.0849
Onchocerca volvulus 0.0024 0.0038 0.0358
Plasmodium falciparum ABC transporter B family member 6, putative 0.0033 0.0079 0.0595
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0038 0.0014
Plasmodium vivax ABC transporter B family member 4, putative 0.0033 0.0079 0.0595
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0038 0.0014
Brugia malayi aspartic protease BmAsp-1, identical 0.0046 0.0144 0.0651
Schistosoma mansoni multidrug resistance protein 0.0104 0.0419 0.1607
Loa Loa (eye worm) ABC transporter 0.0033 0.0079 0.0252
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0038 0.0014
Schistosoma mansoni neuropeptide receptor 0.0024 0.0038 0.0058
Brugia malayi hypothetical protein 0.0046 0.0144 0.0651
Loa Loa (eye worm) hypothetical protein 0.0104 0.0419 0.181
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0158 0.0675 0.2981
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0103 0.0414 0.0391
Brugia malayi putative neuropeptide receptor 0.0024 0.0038 0.0173
Loa Loa (eye worm) hypothetical protein 0.0054 0.0182 0.0723
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0046 0.0144 0.0487
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0038 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0038 0.0058
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0038 0.0014
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0038 0.0065
Echinococcus granulosus multidrug resistance protein 1 0.0104 0.0419 0.0396
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0033 0.0079 0.0235
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0033 0.0079 0.0235
Schistosoma mansoni histamine h1 receptor 0.0024 0.0038 0.0058
Schistosoma mansoni hypothetical protein 0.0024 0.0038 0.0058
Toxoplasma gondii aspartyl protease 0.0046 0.0144 0.1839
Schistosoma mansoni cathepsin D (A01 family) 0.0538 0.2484 1
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0054 0.0182 0.0824
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0038 0.0014
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0054 0.0182 0.0158
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0038 0.0014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Echinococcus granulosus ATP binding cassette sub family B 0.0033 0.0079 0.0055
Brugia malayi Pepsin A precursor 0.0046 0.0144 0.0651
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0104 0.0419 0.6071
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Schistosoma mansoni multidrug resistance protein 0.0033 0.0079 0.0224
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0038 0.0014
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0104 0.0419 0.0396
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0038 0.0014
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0104 0.0419 0.6071
Echinococcus granulosus ATP binding cassette sub family B 0.0033 0.0079 0.0055
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0156 0.0605
Loa Loa (eye worm) aspartyl protease 6 0.0046 0.0144 0.0548
Toxoplasma gondii aspartyl protease ASP3 0.0128 0.0532 0.7796
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.048 0.2208 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0104 0.0419 0.6071
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0125 0.0518 0.7582
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0033 0.0079 0.0224
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0038 0.0173
Schistosoma mansoni opsin-like receptor 0.0024 0.0038 0.0058
Entamoeba histolytica P-glycoprotein 5, putative 0.0031 0.0074 0.0107
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0033 0.0079 0.0847
Loa Loa (eye worm) hypothetical protein 0.0033 0.0083 0.0269
Plasmodium falciparum plasmepsin IV 0.0158 0.0675 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0042 0.0075
Schistosoma mansoni adenoreceptor 0.0024 0.0038 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0038 0.0058
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0033 0.0079 0.0595
Loa Loa (eye worm) hypothetical protein 0.0031 0.0074 0.0228
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0038 0.0065
Onchocerca volvulus 0.0024 0.0038 0.0358
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0033 0.0079 0.0359
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0038 0.0058
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0513 0.2366 1
Brugia malayi Melatonin receptor type 1A 0.0024 0.0038 0.0173
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0104 0.0419 0.6071
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0033 0.0079 0.0235
Brugia malayi aspartic protease BmAsp-2, identical 0.0046 0.0144 0.0651
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0038 0.0065
Echinococcus granulosus hypothetical protein 0.0024 0.0038 0.0014
Schistosoma mansoni spingomyelin synthetase-related 0.0054 0.0182 0.0642
Plasmodium falciparum ABC transporter B family member 5, putative 0.0033 0.0079 0.0595
Plasmodium falciparum plasmepsin VIII, putative 0.0046 0.0144 0.1614
Onchocerca volvulus 0.0024 0.0038 0.0358
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0046 0.0144 0.0487
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0038 0.0058
Plasmodium vivax sphingomyelin synthase 1, putative 0.0054 0.0182 0.2216
Echinococcus granulosus fmrfamide receptor 0.0024 0.0038 0.0014
Plasmodium falciparum plasmepsin II 0.0158 0.0675 1
Echinococcus granulosus multidrug resistance protein 1 0.0073 0.027 0.0246
Giardia lamblia Multidrug resistance-associated protein 1 0.0033 0.0079 1
Toxoplasma gondii ABC transporter family protein 0.0033 0.0079 0.0847
Schistosoma mansoni multidrug resistance protein 0.0104 0.0419 0.1607
Schistosoma mansoni hypothetical protein 0.0024 0.0038 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0038 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0038 0.0014
Brugia malayi hypothetical protein 0.0046 0.0144 0.0651
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Entamoeba histolytica hypothetical protein 0.0054 0.0182 0.0339
Leishmania major p-glycoprotein 0.0104 0.0419 0.1688
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0038 0.0014
Echinococcus granulosus g protein coupled receptor 0.0024 0.0038 0.0014
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0033 0.0079 0.0235
Plasmodium vivax ABC transporter B family member 3, putative 0.0033 0.0079 0.0595
Schistosoma mansoni myosin xvIII 0.0024 0.0038 0.0058
Brugia malayi hypothetical protein 0.0024 0.0038 0.0173
Onchocerca volvulus 0.0024 0.0038 0.0358
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0033 0.0079 0.5
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0158 0.0675 0.0653
Loa Loa (eye worm) hypothetical protein 0.0054 0.0182 0.0723
Entamoeba histolytica multidrug resistance protein, putative 0.0033 0.0079 0.0118
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0038 0.0058
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0033 0.0079 0.0847
Toxoplasma gondii hypothetical protein 0.0054 0.0182 0.2425
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0033 0.0079 0.0235
Echinococcus granulosus ATP binding cassette sub family B 0.0031 0.0074 0.005
Entamoeba histolytica P-glycoprotein 6, putative 0.0033 0.0079 0.0118
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0104 0.0419 0.0396
Echinococcus granulosus somatostatin receptor 0.0024 0.0038 0.0014
Plasmodium vivax plasmepsin IV, putative 0.0158 0.0675 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0038 0.0014
Brugia malayi ABC transporter family protein 0.0033 0.0079 0.0359
Plasmodium falciparum plasmepsin IX 0.0128 0.0532 0.7735
Brugia malayi hypothetical protein 0.0033 0.0079 0.0359
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Brugia malayi hypothetical protein 0.0024 0.0038 0.0173
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Brugia malayi multidrug resistance protein 3 0.0104 0.0419 0.1899
Brugia malayi MBOAT family protein 0.0021 0.0024 0.0109
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0125 0.0518 0.2007
Echinococcus multilocularis ATP binding cassette sub family B 0.0033 0.0079 0.0055
Echinococcus multilocularis multidrug resistance associated protein 1 0.0033 0.0079 0.0055
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0046 0.0144 0.1839
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0054 0.0182 0.0824
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0104 0.0419 0.6071
Leishmania major pentamidine resistance protein 1 0.0033 0.0079 0.0235
Entamoeba histolytica ATP-binding cassette protein, putative 0.0033 0.0079 0.0118
Schistosoma mansoni multidrug resistance protein 0.0031 0.0074 0.0202
Loa Loa (eye worm) multidrug resistance protein 3 0.0104 0.0419 0.181
Trichomonas vaginalis abcb9, putative 0.0104 0.0419 0.6071
Entamoeba histolytica P-glycoprotein-2 0.0104 0.0419 0.0849
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0038 0.0014
Echinococcus multilocularis ATP binding cassette sub family B 0.0033 0.0079 0.0055
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0038 0.0058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0033 0.0079 0.0235
Loa Loa (eye worm) hypothetical protein 0.0255 0.1137 0.5097
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0252
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0038 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0038 0.0014
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0104 0.0419 0.0396
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0104 0.0419 0.181
Schistosoma mansoni peptidylglycine monooxygenase 0.0255 0.1137 0.4526
Onchocerca volvulus 0.0024 0.0038 0.0358
Schistosoma mansoni multidrug resistance protein 0.0033 0.0079 0.0224
Brugia malayi follicle stimulating hormone receptor 0.0024 0.0038 0.0173
Onchocerca volvulus 0.0046 0.0144 0.3028
Toxoplasma gondii ABC transporter, putative 0.0033 0.0079 0.0847
Schistosoma mansoni neuropeptide receptor 0.0024 0.0038 0.0058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0054 0.0182 0.0674
Brugia malayi sulfakinin receptor protein 0.0024 0.0038 0.0173
Brugia malayi multidrug resistance related protein 1 0.0033 0.0079 0.0359
Echinococcus multilocularis serotonin receptor 0.0024 0.0038 0.0014
Entamoeba histolytica hypothetical protein, conserved 0.1 0.4682 1
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0038 0.0014
Echinococcus granulosus multidrug resistance associated protein 1 0.0033 0.0079 0.0055
Schistosoma mansoni multidrug resistance protein 0.0104 0.0419 0.1607
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0038 0.0014
Echinococcus multilocularis somatostatin receptor 0.0024 0.0038 0.0014
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0038 0.0014
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0054 0.0182 0.0824
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Echinococcus granulosus multidrug resistance protein 1 0.0073 0.027 0.0246
Brugia malayi hypothetical protein 0.0024 0.0038 0.0173
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0479 0.2085
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0104 0.0419 0.6071
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0038 0.0058
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0074 0.0764
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0054 0.0182 0.2425
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0031 0.0074 0.0202
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0104 0.0419 0.6071
Onchocerca volvulus 0.0024 0.0038 0.0358
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0083 0.0375
Schistosoma mansoni amine GPCR 0.0024 0.0038 0.0058
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0104 0.0419 0.6071
Entamoeba histolytica ATP-binding cassette protein, putative 0.0033 0.0079 0.0118
Echinococcus granulosus allatostatin A receptor 0.0024 0.0038 0.0014
Plasmodium falciparum multidrug resistance-associated protein 1 0.0033 0.0079 0.0595
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0038 0.0014
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0104 0.0419 0.6071
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0125 0.0518 0.226
Plasmodium falciparum multidrug resistance protein 1 0.0104 0.0419 0.5963
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Entamoeba histolytica hypothetical protein 0.0054 0.0182 0.0339
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0104 0.0419 0.0396
Entamoeba histolytica P-glycoprotein-2, putative 0.0031 0.0074 0.0107
Brugia malayi ABC transporter 0.0033 0.0079 0.0359
Loa Loa (eye worm) hypothetical protein 0.0158 0.0675 0.2981
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0033 0.0079 0.0235
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0038 0.0014
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0038 0.0014
Trypanosoma brucei p-glycoprotein 0.0033 0.0079 0.0235
Plasmodium vivax aspartyl protease, putative 0.0128 0.0532 0.7735
Schistosoma mansoni smdr1 0.0033 0.0079 0.0224
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0038 0.0358
Onchocerca volvulus 0.0024 0.0038 0.0358
Plasmodium vivax aspartyl proteinase, putative 0.0046 0.0144 0.1614
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0038 0.0058
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0158 0.0675 0.2647
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0158 0.0675 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0038 0.0014
Giardia lamblia ABC transporter, putative 0.0033 0.0079 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0074 0.0764
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0038 0.0058
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0054 0.0182 0.0824
Schistosoma mansoni neuropeptide receptor 0.0024 0.0038 0.0058
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0104 0.0419 0.6071
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0038 0.0173
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0104 0.0419 0.6071
Brugia malayi G protein-coupled receptor 0.0024 0.0038 0.0173
Leishmania major ABC-thiol transporter 0.0033 0.0079 0.0235
Brugia malayi ABC transporter 0.0031 0.0074 0.0334
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0033 0.0079 0.0847
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0038 0.0173
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0038 0.0014
Echinococcus granulosus neuropeptide s receptor 0.0024 0.0038 0.0014
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0038 0.0058
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0033 0.0079 0.0595
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0033 0.0079 0.5
Entamoeba histolytica hypothetical membrane-spanning protein 0.0054 0.0182 0.0339
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0158 0.0675 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0156 0.0605
Schistosoma mansoni amine GPCR 0.0024 0.0038 0.0058
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0038 0.0058
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0038 0.0014
Brugia malayi MH2 domain containing protein 0.0117 0.0479 0.2171
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0104 0.0419 0.0396
Schistosoma mansoni hypothetical protein 0.0033 0.0083 0.0239
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0038 0.0058
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0033 0.0079 0.0235
Echinococcus multilocularis multidrug resistance protein 1 0.0073 0.027 0.0246
Entamoeba histolytica ABC transporter, putative 0.0033 0.0079 0.0118
Schistosoma mansoni hypothetical protein 0.0024 0.0038 0.0058
Trichomonas vaginalis ABC transporter, putative 0.0104 0.0419 0.6071
Brugia malayi P-glycoprotein-like protein 0.0033 0.0079 0.0359
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0038 0.0014
Schistosoma mansoni multidrug resistance protein 0.0033 0.0079 0.0224
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0054 0.0182 0.2216
Brugia malayi MBOAT family protein 0.0021 0.0024 0.0109
Brugia malayi ABC transporter transmembrane region family protein 0.0033 0.0079 0.0359
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0038 0.0058
Schistosoma mansoni opsin-like receptor 0.0024 0.0038 0.0058
Brugia malayi ABC transporter family protein 0.0104 0.0419 0.1899
Loa Loa (eye worm) hypothetical protein 0.048 0.2208 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0038 0.0014
Brugia malayi AKH receptor 0.0024 0.0038 0.0173
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0038 0.0014
Toxoplasma gondii aspartyl protease ASP1 0.0158 0.0675 1
Trypanosoma brucei inositol phosphorylceramide synthase 0.0054 0.0182 0.0674
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0054 0.0182 0.2425
Onchocerca volvulus 0.0024 0.0038 0.0358
Echinococcus granulosus neuropeptide receptor A26 0.0024 0.0038 0.0014
Leishmania major hypothetical protein, conserved 0.0025 0.0042 0.0075
Plasmodium vivax sphingomyelin synthase 2, putative 0.0054 0.0182 0.2216
Brugia malayi MBOAT family protein 0.0021 0.0024 0.0109
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Leishmania major p-glycoprotein e 0.0033 0.0079 0.0235
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Plasmodium vivax multidrug resistance protein 1, putative 0.0104 0.0419 0.5963
Brugia malayi Serotonin receptor 0.0024 0.0038 0.0173
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0038 0.0058
Schistosoma mansoni amine GPCR 0.0024 0.0038 0.0058
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0024 0.0038 0.0065
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0158 0.0675 0.0653
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0033 0.0079 0.0252
Loa Loa (eye worm) hypothetical protein 0.0054 0.0182 0.0723
Plasmodium falciparum plasmepsin V 0.0046 0.0144 0.1614
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0073 0.027 0.3776
Plasmodium vivax multidrug resistance protein 2, putative 0.0033 0.0079 0.0595
Brugia malayi hypothetical protein 0.0024 0.0038 0.0173
Plasmodium falciparum ABC transporter B family member 7, putative 0.0033 0.0079 0.0595
Loa Loa (eye worm) hypothetical protein 0.0031 0.0074 0.0228
Loa Loa (eye worm) ABC transporter 0.0033 0.0079 0.0252
Echinococcus multilocularis multidrug resistance protein 1 0.0104 0.0419 0.0396
Schistosoma mansoni opsin-like receptor 0.0024 0.0038 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0182 0.2425
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0104 0.0419 0.1688
Brugia malayi RE15519p 0.0024 0.0038 0.0173
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.048 0.2208 0.2189
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0104 0.0419 0.5
Schistosoma mansoni amine GPCR 0.0024 0.0038 0.0058
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0104 0.0419 0.6071
Schistosoma mansoni hypothetical protein 0.0024 0.0038 0.0058
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0038 0.0014
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0046 0.0144 0.0487
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0038 0.0173
Echinococcus multilocularis neuropeptide receptor A26 0.0024 0.0038 0.0014
Echinococcus multilocularis neuropeptide s receptor 0.0024 0.0038 0.0014
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0033 0.0079 0.0235
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0038 0.0014
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0104 0.0419 0.6071
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0038 0.0065
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0038 0.0058
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0038 0.0014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Brugia malayi ABC transporter family protein 0.0033 0.0079 0.0359
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0038 0.0065
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0038 0.0058
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0104 0.0419 0.6071
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0033 0.0079 0.0235
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0038 0.0014
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0038 0.0014
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0126 0.0522 0.2363
Entamoeba histolytica hypothetical protein 0.0033 0.0079 0.0118
Brugia malayi Eukaryotic aspartyl protease family protein 0.0046 0.0144 0.0651
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0038 0.0014
Brugia malayi Hhat protein 0.0021 0.0024 0.0109
Trypanosoma brucei multidrug resistance protein E 0.0033 0.0079 0.0235
Echinococcus granulosus orexin receptor type 2 0.0024 0.0038 0.0014
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0038 0.0014
Loa Loa (eye worm) hypothetical protein 0.0046 0.0144 0.0548
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0038 0.0173
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0038 0.0014
Echinococcus granulosus g protein coupled receptor 0.0024 0.0038 0.0014
Brugia malayi neuropeptide F receptor 0.0024 0.0038 0.0173
Echinococcus granulosus neuropeptide receptor 0.0024 0.0038 0.0014
Brugia malayi GnHR receptor homolog 0.0024 0.0038 0.0173
Echinococcus multilocularis ATP binding cassette sub family B 0.0033 0.0079 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0038 0.0058
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0038 0.0014
Plasmodium vivax ABC transporter B family member 5, putative 0.0033 0.0079 0.0595
Onchocerca volvulus 0.0024 0.0038 0.0358
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0038 0.0014
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0033 0.0079 0.0235
Entamoeba histolytica P-glycoprotein-2 0.0104 0.0419 0.0849
Echinococcus granulosus serotonin receptor 0.0024 0.0038 0.0014
Plasmodium falciparum ABC transporter B family member 3, putative 0.0033 0.0079 0.0595
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0125 0.0518 0.0495
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0033 0.0079 0.5
Onchocerca volvulus 0.0024 0.0038 0.0358
Plasmodium falciparum multidrug resistance-associated protein 2 0.0033 0.0079 0.0595
Loa Loa (eye worm) hypothetical protein 0.0104 0.0419 0.181
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0038 0.0058
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0125 0.0518 0.7582
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0054 0.0182 0.2425
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Echinococcus granulosus multidrug resistance protein 1 0.0104 0.0419 0.0396
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0038 0.0014
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0513 0.2366 1
Brugia malayi hypothetical protein 0.0024 0.0038 0.0173
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0513 0.2366 1
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0038 0.0014
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0054 0.0182 0.0824
Onchocerca volvulus 0.0024 0.0038 0.0358
Entamoeba histolytica P-glycoprotein 6, putative 0.0033 0.0079 0.0118
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0038 0.0014
Plasmodium falciparum multidrug resistance protein 2 0.0033 0.0079 0.0595
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0479 0.2085
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0513 0.2366 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0038 0.0014
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0046 0.0144 0.0487
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0038 0.0058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Trichomonas vaginalis ABC transporter, putative 0.0104 0.0419 0.6071
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2118 1 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0046 0.0144 0.0487
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0038 0.0014
Onchocerca volvulus 0.0024 0.0038 0.0358
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0104 0.0419 0.6071
Entamoeba histolytica hypothetical protein 0.0054 0.0182 0.0339
Schistosoma mansoni amine GPCR 0.0024 0.0038 0.0058
Plasmodium vivax ABC transporter B family member 6, putative 0.0033 0.0079 0.0595
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0038 0.0058
Brugia malayi hypothetical protein 0.0024 0.0038 0.0173
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0038 0.0065
Brugia malayi G-protein coupled receptor 0.0024 0.0038 0.0173
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0038 0.0014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0038 0.0014
Loa Loa (eye worm) hypothetical protein 0.0046 0.0144 0.0548
Echinococcus granulosus neuropeptide receptor 0.0024 0.0038 0.0014
Brugia malayi ABC transporter transmembrane region family protein 0.0033 0.0079 0.0359
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.048 0.2208 0.2189
Trichomonas vaginalis hypothetical protein 0.0054 0.0182 0.2425
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Loa Loa (eye worm) hypothetical protein 0.0104 0.0418 0.1803
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0038 0.0014
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0104 0.0419 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.008
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0033 0.0079 0.0235
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0038 0.0014
Loa Loa (eye worm) ABC transporter 0.0033 0.0079 0.0252
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0513 0.2366 1
Plasmodium vivax aspartyl protease, putative 0.0128 0.0532 0.7735
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0104 0.0419 0.0396
Brugia malayi MBOAT family protein 0.0021 0.0024 0.0109
Plasmodium vivax aspartyl proteinase, putative 0.0158 0.0675 1
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0038 0.0014
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0038 0.0014
Echinococcus multilocularis sex peptide receptor 0.0024 0.0038 0.0014
Onchocerca volvulus 0.0024 0.0038 0.0358
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0038 0.0014
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0038 0.0014
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0046 0.0144 0.0487
Plasmodium vivax ABC transporter B family member 7, putative 0.0033 0.0079 0.0595
Plasmodium falciparum ABC transporter B family member 4, putative 0.0033 0.0079 0.0595
Brugia malayi hypothetical protein 0.0024 0.0038 0.0173
Entamoeba histolytica ATP-binding cassette protein, putative 0.0033 0.0079 0.0118
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0125 0.0518 0.7515
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0038 0.0058
Echinococcus multilocularis 0.0033 0.0079 0.0055
Schistosoma mansoni dopamine-beta-monooxygenase 0.0255 0.1137 0.4526
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Brugia malayi hypothetical protein 0.0024 0.0038 0.0173
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0038 0.0014
Giardia lamblia MRP-like ABC transporter 0.0033 0.0079 1
Echinococcus granulosus multidrug resistance associated protein 7 0.0033 0.0079 0.0055
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0038 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0074 0.0764
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0252
Echinococcus multilocularis ATP binding cassette sub family B 0.0033 0.0079 0.0055
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0038 0.0058
Echinococcus multilocularis multidrug resistance protein 1 0.0104 0.0419 0.0396
Trichomonas vaginalis abcb9, putative 0.0104 0.0419 0.6071
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0033 0.0079 0.0847
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0104 0.0419 0.6071
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Echinococcus multilocularis ATP binding cassette sub family B 0.0103 0.0414 0.0391
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0038 0.0014
Trypanosoma cruzi multidrug resistance protein E, putative 0.0033 0.0079 0.0235
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0038 0.0173
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0104 0.0419 0.6071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0038 0.0058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Brugia malayi MBOAT family protein 0.0021 0.0024 0.0109
Treponema pallidum alginate O-acetylation protein (algI) 0.0021 0.0024 0.5
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0033 0.0079 0.0847
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0033 0.0079 0.5
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0125 0.0518 0.7515
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0042 0.0075
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Echinococcus multilocularis multidrug resistance associated protein 7 0.0033 0.0079 0.0055
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0033 0.0079 0.0235
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0104 0.0419 0.6071
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0125 0.0518 0.0495
Echinococcus granulosus g protein coupled receptor 0.0024 0.0038 0.0014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0156 0.0707
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0038 0.0058
Entamoeba histolytica ATP-binding cassette protein, putative 0.0033 0.0079 0.0118
Echinococcus granulosus sphingomyelin synthase protein 1 0.0054 0.0182 0.0158
Trichomonas vaginalis taga, putative 0.0104 0.0419 0.6071
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0042 0.0075
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0046 0.0144 0.0487
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0054 0.0182 0.2216
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0104 0.0419 0.6071
Echinococcus granulosus multidrug resistance protein 1 0.0104 0.0419 0.0396
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Plasmodium falciparum plasmepsin VI 0.0158 0.0675 1
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0129 0.054 0.2445
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0038 0.0014
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0054 0.0182 0.2425
Schistosoma mansoni neuropeptide receptor 0.0024 0.0038 0.0058
Plasmodium vivax plasmepsin V, putative 0.0046 0.0144 0.1614
Schistosoma mansoni peptidyl-glycine monooxygenase 0.048 0.2208 0.888
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0038 0.0014
Brugia malayi neuropeptide F receptor 0.0024 0.0038 0.0173
Brugia malayi ORL1-like opioid receptor 0.0024 0.0038 0.0173
Entamoeba histolytica P-glycoprotein 5, putative 0.0104 0.0419 0.0849
Loa Loa (eye worm) hypothetical protein 0.0103 0.0414 0.1785
Plasmodium vivax aspartyl protease, putative 0.0046 0.0144 0.1614
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0038 0.0014
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0033 0.0079 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0038 0.0014
Echinococcus multilocularis serotonin receptor 0.0024 0.0038 0.0014
Schistosoma mansoni cathepsin D (A01 family) 0.0538 0.2484 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0042 0.0268
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0038 0.0014
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0033 0.0079 0.0847
Brugia malayi Serotonin receptor 0.0024 0.0038 0.0173
Entamoeba histolytica hypothetical protein 0.0054 0.0182 0.0339
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0038 0.0065
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0038 0.0058
Onchocerca volvulus 0.0024 0.0038 0.0358
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0104 0.0419 0.6071
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0054 0.0182 0.2216
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0074 0.0764
Schistosoma mansoni biogenic amine receptor 0.0024 0.0038 0.0058
Plasmodium falciparum plasmepsin VII 0.0046 0.0144 0.1614
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0038 0.0065
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0038 0.0173
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0038 0.0014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Brugia malayi diacylglycerol acyltransferase 0.0125 0.0518 0.2344
Entamoeba histolytica P-glyco protein 6, putative 0.0104 0.0419 0.0849
Onchocerca volvulus 0.0024 0.0038 0.0358
Trichomonas vaginalis abcb9, putative 0.0104 0.0419 0.6071
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0038 0.0358
Onchocerca volvulus 0.0024 0.0038 0.0358
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0252
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0038 0.0014
Schistosoma mansoni multidrug resistance protein 0.0033 0.0079 0.0224
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0104 0.0419 0.6071
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Plasmodium falciparum plasmepsin III 0.0046 0.0144 0.1614
Brugia malayi ABC transporter family protein 0.0033 0.0079 0.0359
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0038 0.0014
Brugia malayi larval opioid receptor 0.0024 0.0038 0.0173
Trichomonas vaginalis ABC transporter, putative 0.0104 0.0419 0.6071
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0038 0.0014
Schistosoma mansoni multidrug resistance protein 0.0033 0.0079 0.0224
Loa Loa (eye worm) hypothetical protein 0.0054 0.0182 0.0723
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Entamoeba histolytica P-glycoprotein-2, putative 0.0104 0.0419 0.0849
Schistosoma mansoni smdr2 0.0104 0.0419 0.1607
Brugia malayi Sphingomyelin synthase-related 1 0.0054 0.0182 0.0824
Brugia malayi hypothetical protein 0.0024 0.0038 0.0173
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Loa Loa (eye worm) hypothetical protein 0.0054 0.0182 0.0723
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0038 0.0014
Trichomonas vaginalis ABC transporter, putative 0.0104 0.0419 0.6071
Schistosoma mansoni biogenic amine receptor 0.0024 0.0038 0.0058
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0104 0.0419 0.0396
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0038 0.0058
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0033 0.0079 0.0847
Brugia malayi Dopamine receptor protein 1 0.0024 0.0038 0.0173
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0033 0.0079 0.0235
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0033 0.0079 0.5
Onchocerca volvulus 0.0046 0.0144 0.3028
Loa Loa (eye worm) hypothetical protein 0.0054 0.0182 0.0723
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0038 0.0065
Brugia malayi hypothetical protein 0.0025 0.0042 0.0188
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0104 0.0419 0.6071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0038 0.0014
Entamoeba histolytica P-glycoprotein-5 0.0104 0.0419 0.0849
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0038 0.0014
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0038 0.0014
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0255 0.1137 0.515
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0104 0.0419 0.0396
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0104 0.0419 0.0396
Echinococcus granulosus sex peptide receptor 0.0024 0.0038 0.0014
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0046 0.0144 0.0548
Onchocerca volvulus 0.0104 0.0419 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0156 0.0707
Brugia malayi Dopamine receptor 0.0024 0.0038 0.0173
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0038 0.0014
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0038 0.0014
Brugia malayi Dopamine receptor protein 2 0.0024 0.0038 0.0173
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0038 0.0014
Brugia malayi hypothetical protein 0.0024 0.0038 0.0173
Entamoeba histolytica hypothetical protein 0.0054 0.0182 0.0339
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0104 0.0419 0.6071
Plasmodium falciparum plasmepsin X 0.0128 0.0532 0.7735
Brugia malayi G-protein coupled receptor 0.0024 0.0038 0.0173
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0038 0.0058
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0065
Plasmodium falciparum plasmepsin I 0.0158 0.0675 1
Onchocerca volvulus 0.0024 0.0038 0.0358
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0033 0.0079 0.5
Giardia lamblia Multidrug resistance-associated protein 1 0.0033 0.0079 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0046 0.0144 0.0487

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.02 uM Inhibition of isolated human PDGF receptor phosphorylation ChEMBL. 8035419
IC50 (binding) = 0.02 uM Inhibition of isolated human PDGF receptor phosphorylation ChEMBL. 8035419

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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