Detailed information for compound 1109111

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 332.371 | Formula: C21H17FN2O
  • H donors: 0 H acceptors: 1 LogP: 5.29 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cccc(c1)c1ccc2c(c1)cnn2c1ccc(cc1)F
  • InChi: 1S/C21H17FN2O/c1-2-25-20-5-3-4-15(13-20)16-6-11-21-17(12-16)14-23-24(21)19-9-7-18(22)8-10-19/h3-14H,2H2,1H3
  • InChiKey: GHPKGWAUDHFBQX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Starlite/ChEMBL References
Homo sapiens androgen receptor Starlite/ChEMBL References
Homo sapiens progesterone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pax transcription factor protein 2 0.052 0.1181 0.1181
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0035 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0028 0.0028
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0035 0.0198
Echinococcus multilocularis zinc finger transcription factor gli2 0.0323 0.072 0.0715
Onchocerca volvulus 0.004 0.0057 0.0412
Leishmania major hypothetical protein, unknown function,protein, unknown function 0.0124 0.0254 0.1933
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0057 0.0511
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0035 0.1026
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0005 0.0005
Brugia malayi Hhat protein 0.0106 0.0211 0.0211
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0009 0.0078
Schistosoma mansoni hypothetical protein 0.0686 0.1571 0.1567
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.4285 1 1
Schistosoma mansoni chromobox protein 0.0077 0.0143 0.0138
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0035 0.031
Brugia malayi ecdysteroid receptor 0.0027 0.0028 0.0028
Brugia malayi beta-lactamase family protein 0.004 0.0057 0.0057
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0005 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0057 0.0052
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0028 0.0023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0035 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0064 0.0576
Brugia malayi CHD4 protein 0.0018 0.0006 0.0006
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0047 0.0297
Brugia malayi Zinc finger, C2H2 type family protein 0.0323 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0028 0.0023
Schistosoma mansoni hypothetical protein 0.0049 0.0079 0.0074
Brugia malayi hypothetical protein 0.013 0.0267 0.0267
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.003 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0248 0.0545 0.0541
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.056 0.1276 1
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0081 0.0567
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0124 0.0254 0.1933
Brugia malayi Dopamine receptor 0.0017 0.0005 0.0005
Leishmania major glycerol uptake protein, putative 0.0106 0.0211 0.1593
Brugia malayi diacylglycerol acyltransferase family protein 0.056 0.1276 0.1276
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0248 0.0545 0.0541
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.056 0.1276 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0081 0.0503
Loa Loa (eye worm) hypothetical protein 0.005 0.0081 0.0077
Brugia malayi hypothetical protein 0.0017 0.0005 0.0005
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0106 0.0211 0.0207
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0028 0.0023
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0035 0.0176
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0023
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0028 0.0023
Echinococcus granulosus thioredoxin glutathione reductase 0.0088 0.017 0.0165
Leishmania major importin beta-1 subunit, putative 0.0023 0.0018 0.0062
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0629 0.1437 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0097 0.0191 0.0187
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0052
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0106 0.0211 1
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0144 0.0139
Brugia malayi G-protein coupled receptor 0.0017 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0028 0.0028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0035 0.0198
Brugia malayi Bromodomain containing protein 0.0156 0.0329 0.0329
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0088 0.0169 0.2891
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0047 0.0043
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0106 0.0211 0.0207
Loa Loa (eye worm) TAR-binding protein 0.0062 0.011 0.0105
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0009 0.0078
Onchocerca volvulus 0.056 0.1276 1
Brugia malayi GNT-I family protein 0.0324 0.0723 0.0723
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0047 0.0423
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0023
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0009 0.0078
Treponema pallidum NADH oxidase 0.003 0.0035 0.1245
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0245 0.0241
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0191 0.0187
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0057 0.0052
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0057 0.0861
Trichomonas vaginalis conserved hypothetical protein 0.033 0.0736 0.6654
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.02 0.0432 0.7665
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0106 0.0211 0.0207
Mycobacterium tuberculosis Probable reductase 0.02 0.0432 0.7665
Leishmania major glycerol uptake protein, putative 0.0106 0.0211 0.1593
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0035 0.0035
Brugia malayi MH2 domain containing protein 0.012 0.0245 0.0245
Echinococcus granulosus tar DNA binding protein 0.0062 0.011 0.0105
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0076 0.0072
Mycobacterium ulcerans beta-lactamase 0.004 0.0057 0.1936
Mycobacterium tuberculosis Probable oxidoreductase 0.0222 0.0484 0.8614
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0052
Echinococcus granulosus microtubule associated protein 2 0.0677 0.1551 0.1547
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0103 0.0099
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.02 0.0432 0.7665
Leishmania major diacylglycerol acyltransferase, putative 0.056 0.1276 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0222 0.0484 1
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0072 0.0645
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0057 0.0861
Toxoplasma gondii diacylglycerol acyltransferase 0.0124 0.0254 0.1714
Brugia malayi MBOAT family protein 0.0106 0.0211 0.0211
Echinococcus multilocularis zinc finger protein 0.0042 0.0062 0.0057
Entamoeba histolytica hypothetical protein 0.0023 0.0018 0.0386
Brugia malayi neuropeptide F receptor 0.0017 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0124 0.0254 0.025
Loa Loa (eye worm) RNA binding protein 0.0062 0.011 0.0105
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0106 0.0211 0.0207
Mycobacterium tuberculosis Putative ferredoxin reductase 0.02 0.0432 0.7665
Entamoeba histolytica Ran family GTPase 0.0021 0.0013 0.014
Brugia malayi MBOAT family protein 0.0106 0.0211 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0211 0.1907
Schistosoma mansoni hypothetical protein 0.0049 0.0079 0.0074
Trypanosoma brucei glycerol uptake protein, putative 0.0106 0.0211 0.1593
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0144 0.0139
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0143 0.1288
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0013 0.002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0028 0.0023
Entamoeba histolytica hypothetical protein 0.0106 0.0211 1
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0629 0.1437 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0028 0.0023
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0047 0.1537
Brugia malayi AKH receptor 0.0017 0.0005 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0035 0.0198
Trypanosoma brucei ISWI complex protein 0.0031 0.0037 0.0219
Entamoeba histolytica hypothetical protein 0.0077 0.0144 0.6638
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0028 0.0028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0028 0.0023
Mycobacterium tuberculosis Probable dehydrogenase 0.02 0.0432 0.7665
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0035 0.1026
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0796 0.1828 0.1825
Brugia malayi Pre-SET motif family protein 0.0062 0.0109 0.0109
Schistosoma mansoni hypothetical protein 0.0042 0.0063 0.0058
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0023
Trypanosoma brucei glycerol uptake protein, putative 0.0106 0.0211 0.1593
Schistosoma mansoni coup transcription factor 0.0027 0.0028 0.0023
Schistosoma mansoni inositol monophosphatase 0.0036 0.0047 0.0043
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0023
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0106 0.0211 0.0207
Mycobacterium ulcerans lipase LipD 0.004 0.0057 0.1936
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0035 0.1026
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0035 0.0311
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0017 0.0012
Loa Loa (eye worm) MBOAT family protein 0.0106 0.0211 0.0207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0009 0.0078
Loa Loa (eye worm) zinc finger protein 0.0323 0.072 0.0715
Echinococcus granulosus o acyltransferase membrane bound domain 0.0106 0.0211 0.0207
Echinococcus granulosus snurportin 1 0.0302 0.0672 0.0667
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0081 0.0503
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0124 0.0254 0.1933
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0109 0.0104
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0005 0.0005
Brugia malayi nuclear hormone receptor 0.0027 0.0028 0.0028
Toxoplasma gondii dgat2l1-prov protein 0.056 0.1276 0.8869
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0047 1
Treponema pallidum alginate O-acetylation protein (algI) 0.0106 0.0211 1
Schistosoma mansoni cpg binding protein 0.0036 0.0048 0.0044
Brugia malayi Heterochromatin protein 1 0.0077 0.0143 0.0143
Echinococcus granulosus zinc finger protein 0.0042 0.0062 0.0057
Brugia malayi hypothetical protein 0.0032 0.004 0.004
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.4285 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0028 0.0028
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0222 0.0484 0.8614
Brugia malayi MBOAT family protein 0.0106 0.0211 0.0211
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0035 0.0176
Mycobacterium leprae Probable lipase LipE 0.004 0.0057 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.033 0.0736 0.6654
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0013 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0002 0.0011
Schistosoma mansoni hypothetical protein 0.0686 0.1571 0.1567
Loa Loa (eye worm) hypothetical protein 0.0079 0.0149 0.0144
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0103 0.3827
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0013 0.0022
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.056 0.1276 1
Schistosoma mansoni zinc finger protein 0.0042 0.0062 0.0057
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0023
Echinococcus granulosus importin subunit beta 1 0.0028 0.003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0106 0.0211 0.0207
Schistosoma mansoni ap endonuclease 0.002 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0084 0.016 0.0155
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0102 0.0098
Onchocerca volvulus 0.0075 0.0138 0.1052
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0028 0.0028
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0213 0.0213
Brugia malayi Pre-SET motif family protein 0.0429 0.0968 0.0968
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0248 0.0545 0.0545
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0064 0.0576
Toxoplasma gondii hypothetical protein 0.0106 0.0211 0.1413
Schistosoma mansoni hypothetical protein 0.0302 0.0672 0.0667
Schistosoma mansoni tar DNA-binding protein 0.0062 0.011 0.0105
Brugia malayi Thioredoxin reductase 0.0088 0.0169 0.0169
Entamoeba histolytica vacuolar protein sorting 26 0.0106 0.0211 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0075 0.0138 0.0134
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0023
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0124 0.0254 0.1933
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0028 0.0023
Leishmania major glycerol uptake protein, putative 0.0106 0.0211 0.1593
Brugia malayi Glycosylation related protein 12, isoform 0.011 0.0221 0.0221
Schistosoma mansoni ap endonuclease 0.002 0.001 0.0005
Loa Loa (eye worm) glutathione reductase 0.0088 0.0169 0.0164
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0429 0.0968 0.0964
Schistosoma mansoni hypothetical protein 0.0049 0.0079 0.0074
Echinococcus granulosus chromobox protein 1 0.0077 0.0143 0.0138
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0079 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0028 0.0023
Leishmania major hypothetical protein, conserved 0.0106 0.0211 0.1593
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0124 0.0254 0.025
Echinococcus multilocularis dnaJ subfamily B 0.0433 0.0977 0.0973
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0211 0.1907
Schistosoma mansoni cpg binding protein 0.0036 0.0048 0.0044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0057 0.0052
Schistosoma mansoni importin beta-1 0.0028 0.003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0146 0.0306 0.0302
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0629 0.1437 1
Echinococcus multilocularis geminin 0.0686 0.1571 0.1567
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.0328 0.0324
Trichomonas vaginalis conserved hypothetical protein 0.0201 0.0435 0.3928
Brugia malayi hypothetical protein 0.0017 0.0005 0.0005
Trypanosoma cruzi glycerol uptake protein, putative 0.0106 0.0211 0.1593
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0035 0.0198
Leishmania major glycerol uptake protein, putative 0.0106 0.0211 0.1593
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0057 0.1936
Brugia malayi hypothetical protein 0.0077 0.0144 0.0144
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0629 0.1437 0.1433
Loa Loa (eye worm) heterochromatin protein 1 0.0077 0.0143 0.0138
Schistosoma mansoni cpg binding protein 0.003 0.0035 0.003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0079 0.0079
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0028 0.0023
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0081 0.0567
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0324 0.0723 0.0718
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0047 0.0423
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.4285 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0248 0.0545 0.0541
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0028 0.0028
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0035 0.0198
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0013 0.002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0125 0.0255 0.0251
Toxoplasma gondii Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 0.011 0.0221 0.1481
Toxoplasma gondii ABC1 family protein 0.004 0.0057 0.0332
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0047 0.0043
Mycobacterium tuberculosis Conserved protein 0.004 0.0057 0.0861
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0079 0.0074
Brugia malayi Serotonin receptor 0.0017 0.0005 0.0005
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0103 0.0099
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0028 0.0023
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0124 0.0254 0.025
Brugia malayi diacylglycerol acyltransferase 0.0629 0.1437 0.1437
Trichomonas vaginalis conserved hypothetical protein 0.033 0.0736 0.6654
Schistosoma mansoni tar DNA-binding protein 0.0062 0.011 0.0105
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0023
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0629 0.1437 0.1433
Echinococcus multilocularis importin subunit beta 1 0.0028 0.003 0.0025
Loa Loa (eye worm) CHromoDomain protein family member 0.0018 0.0006 0.0002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0047 0.0297
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0047 0.0263
Brugia malayi hypothetical protein 0.005 0.0081 0.0081
Brugia malayi PHD-finger family protein 0.0053 0.0088 0.0088
Brugia malayi Inositol-1 0.0036 0.0047 0.0047
Mycobacterium tuberculosis Conserved protein 0.004 0.0057 0.0861
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0052
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0028 0.0028
Leishmania major GTP-binding protein, putative 0.0021 0.0013 0.0022
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0013 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0028 0.0028
Trichomonas vaginalis ran, putative 0.0021 0.0013 0.0108
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0018 0.0062
Entamoeba histolytica hypothetical protein 0.0077 0.0144 0.6638
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0028 0.0028
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0079 0.0079
Echinococcus multilocularis thioredoxin glutathione reductase 0.0088 0.017 0.0165
Brugia malayi Melatonin receptor type 1A 0.0017 0.0005 0.0005
Echinococcus multilocularis cpg binding protein 0.0036 0.0048 0.0044
Schistosoma mansoni inositol monophosphatase 0.0036 0.0047 0.0043
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.056 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0043 0.0038
Brugia malayi neuropeptide F receptor 0.0017 0.0005 0.0005
Brugia malayi hypothetical protein 0.0017 0.0005 0.0005
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.0106 0.0211 0.0207
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.0328 0.0328
Onchocerca volvulus 0.0146 0.0306 0.2372
Leishmania major diacylglycerol acyltransferase, putative 0.0124 0.0254 0.1933
Onchocerca volvulus 0.052 0.1181 0.9254
Brugia malayi CXXC zinc finger family protein 0.003 0.0035 0.0035
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0057 0.0861
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.001 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.033 0.0736 0.6654
Brugia malayi RNA, U transporter 1 0.0081 0.0152 0.0152
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0028 0.0184
Onchocerca volvulus 0.0027 0.0028 0.0184
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0028 0.003 0.0025
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0106 0.0211 0.0207
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0081 0.0567
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0018 0.0153
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0035 0.0176
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0035 0.031
Brugia malayi hypothetical protein 0.0017 0.0005 0.0005
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.1551 0.1547
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0057 0.0511
Brugia malayi beta-lactamase family protein 0.004 0.0057 0.0057
Trichomonas vaginalis transmembrane protein nessy, putative 0.0106 0.0211 0.1907
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0018 0.0006 0.0002
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0047 0.0297
Echinococcus granulosus chromobox protein 1 0.0077 0.0143 0.0138
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0057 0.0511
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0076 0.0072
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0028 0.0023
Onchocerca volvulus 0.003 0.0035 0.0238
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0106 0.0211 0.0207
Leishmania major glycerol uptake protein, putative 0.0106 0.0211 0.1593
Brugia malayi TAR-binding protein 0.0062 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0052
Loa Loa (eye worm) hypothetical protein 0.0043 0.0064 0.006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0047 0.0297
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0057 0.0374
Schistosoma mansoni hypothetical protein 0.0433 0.0977 0.0973
Brugia malayi putative neuropeptide receptor 0.0017 0.0005 0.0005
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0064 0.0469
Schistosoma mansoni ran 0.0021 0.0013 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0062 0.011 0.0105
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0629 0.1437 0.1433
Brugia malayi hypothetical protein 0.0017 0.0005 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0028 0.0023
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0009 0.0078
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0124 0.0254 0.1933
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0005 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0088 0.0169 0.1257
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0028 0.0023
Trypanosoma brucei trypanothione reductase 0.0088 0.0169 0.1257
Echinococcus granulosus sterol O acyltransferase 1 0.0106 0.0211 0.0207
Brugia malayi G-protein coupled receptor 0.0017 0.0005 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0103 0.0099
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0115 0.0739
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.056 0.1276 0.1272
Brugia malayi Importin beta-1 subunit 0.0028 0.003 0.003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0248 0.0545 0.0541
Echinococcus granulosus o acyltransferase membrane bound domain 0.0106 0.0211 0.0207
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0035 0.0198
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0009 0.0078
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.02 0.0432 0.8827
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0109 0.0104
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0028 0.0023
Schistosoma mansoni zinc finger protein 0.0106 0.0211 0.0207
Plasmodium falciparum glutathione reductase 0.0088 0.0169 0.1115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0248 0.0545 0.0541
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0057 0.0861
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0103 0.074
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0109 0.0696
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0106 0.0211 1
Brugia malayi hypothetical protein 0.0017 0.0005 0.0005
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0035 0.0198
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0063 0.0058
Plasmodium falciparum importin beta, putative 0.0028 0.003 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.033 0.0736 0.6654
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0106 0.0211 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0018 0.0153
Loa Loa (eye worm) hhat protein 0.0106 0.0211 0.0207
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0103 0.0656
Loa Loa (eye worm) hypothetical protein 0.0324 0.0723 0.0718
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.003 0.0161
Leishmania major hypothetical protein, conserved 0.0031 0.0037 0.0219
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0046 0.0041
Schistosoma mansoni hypothetical protein 0.0031 0.0037 0.0033
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.02 0.0432 0.7665
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0028 0.0023
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0076 0.0072
Schistosoma mansoni hypothetical protein 0.0049 0.0079 0.0074
Echinococcus multilocularis GPCR, family 2 0.0049 0.0079 0.0074
Echinococcus multilocularis chromobox protein 1 0.0077 0.0143 0.0138
Schistosoma mansoni tar DNA-binding protein 0.0062 0.011 0.0105
Trichomonas vaginalis ap endonuclease, putative 0.002 0.001 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0028 0.0028
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0057 0.0861
Echinococcus granulosus alpha 13 mannosyl glycoprotein 0.0324 0.0723 0.0718
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0222 0.0484 0.8614
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0103 0.0099
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0028 0.0184
Trichomonas vaginalis set domain proteins, putative 0.0488 0.1106 1
Schistosoma mansoni alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase 0.0324 0.0723 0.0718
Entamoeba histolytica hypothetical protein, conserved 0.0106 0.0211 1
Trypanosoma cruzi ISWI complex protein 0.0031 0.0037 0.0219
Brugia malayi MBOAT family protein 0.0106 0.0211 0.0211
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0009 0.0078
Echinococcus granulosus dnaJ subfamily B 0.0433 0.0977 0.0973
Toxoplasma gondii hypothetical protein 0.0129 0.0265 0.179
Leishmania major diacylglycerol acyltransferase, putative 0.0124 0.0254 0.1933
Schistosoma mansoni chromobox protein 0.0077 0.0143 0.0138
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.011 0.0105
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0035 0.6676
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0137 0.0132
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0035 0.0176
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0191 0.0187
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0057 0.0374
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0106 0.0211 0.0207
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0106 0.0211 0.0207
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0028 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0062 0.011 0.0105
Plasmodium vivax hypothetical protein, conserved 0.004 0.0057 0.0332
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0035 0.0198
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0035 0.0456
Brugia malayi G protein-coupled receptor 0.0017 0.0005 0.0005
Trypanosoma cruzi ISWI complex protein 0.0031 0.0037 0.0219
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0023
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0028 0.0023
Loa Loa (eye worm) inositol-1 0.0036 0.0047 0.0043
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0018 0.0006 0.0002
Echinococcus granulosus GPCR family 2 0.0049 0.0079 0.0074
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0057 0.0052
Loa Loa (eye worm) thioredoxin reductase 0.0088 0.0169 0.0164
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0035 0.0198
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0137 0.0132
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0072 0.0529
Brugia malayi hypothetical protein 0.0017 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0523 0.119 0.1185
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0035 0.0311
Brugia malayi steroid hormone receptor 0.0027 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0106 0.0213 0.0208
Trichomonas vaginalis porcupine, putative 0.0106 0.0211 0.1907
Echinococcus multilocularis sterol O acyltransferase 1 0.0106 0.0211 0.0207
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0005 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0057 0.0374
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0018 0.0006 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0245 0.0241
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0103 0.3827
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0035 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0057 0.0511
Trypanosoma cruzi GUP1, putative 0.0106 0.0211 0.1593
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.013 0.0267 0.0263
Loa Loa (eye worm) hypothetical protein 0.0097 0.0191 0.0187
Loa Loa (eye worm) hypothetical protein 0.0106 0.0211 0.0207
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0035 0.003
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0057 0.0052
Plasmodium falciparum glutathione reductase 0.003 0.0035 0.0176
Brugia malayi RE15519p 0.0017 0.0005 0.0005
Schistosoma mansoni ran 0.0021 0.0013 0.0008
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0079 0.0074
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0106 0.0211 0.0207
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0035 0.0198
Brugia malayi Dopamine receptor protein 1 0.0017 0.0005 0.0005
Trypanosoma cruzi glycerol uptake protein, putative 0.0106 0.0211 0.1593
Loa Loa (eye worm) diacylglycerol acyltransferase 0.056 0.1276 0.1272
Onchocerca volvulus 0.0034 0.0043 0.0298
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0046 0.0041
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0057 0.1936
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0046 0.0041
Mycobacterium leprae conserved hypothetical protein 0.004 0.0057 0.0416
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0035 0.0176
Onchocerca volvulus Huntingtin homolog 0.013 0.0267 0.2066
Mycobacterium ulcerans hypothetical protein 0.0124 0.0254 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0028 0.0023
Plasmodium vivax SET domain protein, putative 0.0062 0.0109 0.0696
Loa Loa (eye worm) hypothetical protein 0.0106 0.0213 0.0208
Entamoeba histolytica hypothetical protein 0.0077 0.0144 0.6638
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0106 0.0211 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0028 0.0028
Brugia malayi RNA binding protein 0.0062 0.011 0.011
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0005 0.0005
Plasmodium vivax glutathione reductase, putative 0.0088 0.0169 0.1115
Trichomonas vaginalis conserved hypothetical protein 0.033 0.0736 0.6654
Brugia malayi Bromodomain containing protein 0.0079 0.0148 0.0148
Schistosoma mansoni sterol O-acyltransferase 1 0.0106 0.0211 0.0207
Brugia malayi GnHR receptor homolog 0.0017 0.0005 0.0005
Brugia malayi MBOAT family protein 0.0106 0.0211 0.0211
Schistosoma mansoni zinc finger protein 0.0031 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.011 0.0221 0.0217
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0018 0.0153
Loa Loa (eye worm) MBOAT family protein 0.0106 0.0211 0.0207
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0035 0.0198
Leishmania major trypanothione reductase 0.0088 0.0169 0.1257
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0013 0.0008
Brugia malayi larval opioid receptor 0.0017 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.033 0.0736 0.6654
Brugia malayi beta-lactamase 0.004 0.0057 0.0057
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0156 0.0328 0.0324
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0035 0.0198
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0103 0.3827
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0079 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0211 0.1907
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0028 0.0023
Brugia malayi hypothetical protein 0.0017 0.0005 0.0005
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0028 0.0023
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0028 0.0023
Trichomonas vaginalis esterase, putative 0.004 0.0057 0.0511
Echinococcus granulosus histone lysine methyltransferase setb 0.0097 0.0191 0.0187
Onchocerca volvulus 0.004 0.0057 0.0412
Toxoplasma gondii mono- or diacylglycerol acyltransferase 0.0124 0.0254 0.1714
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0081 0.0503
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0248 0.0545 0.0541
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0106 0.0211 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0028 0.0023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.012 0.0115
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0143 0.1288
Echinococcus multilocularis tar DNA binding protein 0.0062 0.011 0.0105
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0005 0.0005
Plasmodium falciparum thioredoxin reductase 0.0088 0.0169 0.1115
Mycobacterium ulcerans hypothetical protein 0.004 0.0057 0.1936
Loa Loa (eye worm) hypothetical protein 0.0145 0.0304 0.03
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0629 0.1437 0.1433
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0028 0.0028
Trypanosoma cruzi glycerol uptake protein, putative 0.0106 0.0211 0.1593
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0057 0.0861
Loa Loa (eye worm) MBOAT family protein 0.0106 0.0211 0.0207
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0035 0.003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0028 0.0023
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0013 0.0013
Trypanosoma cruzi GUP1, putative 0.0106 0.0211 0.1593
Brugia malayi sulfakinin receptor protein 0.0017 0.0005 0.0005
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0035 0.0198
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0077 0.0144 0.0139
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0028 0.0023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.0106 0.0211 0.0207
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0106 0.0211 0.0207
Brugia malayi Dopamine receptor protein 2 0.0017 0.0005 0.0005
Mycobacterium tuberculosis Conserved protein 0.004 0.0057 0.0861
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0028 0.0023
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0629 0.1437 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.003 0.0142
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0047 0.1864
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0049 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0035 0.0198
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0028 0.0023
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0035 0.0198
Loa Loa (eye worm) hypothetical protein 0.0089 0.0173 0.0169
Loa Loa (eye worm) hypothetical protein 0.013 0.0267 0.0263
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0106 0.0211 0.0207
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0013 0.002
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0046 0.0041
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0039 0.0524
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0016 0.0016
Brugia malayi hypothetical protein 0.0146 0.0306 0.0306
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0144 0.0139
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0013 0.0022
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0035 0.003
Loa Loa (eye worm) beta-lactamase 0.004 0.0057 0.0052
Echinococcus granulosus geminin 0.0686 0.1571 0.1567
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0013 0.1126
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0057 0.0861
Onchocerca volvulus 0.0106 0.0211 0.1626
Loa Loa (eye worm) hypothetical protein 0.0049 0.0079 0.0074
Brugia malayi hypothetical protein 0.0017 0.0005 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0005 0.0005
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0017 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0248 0.0545 0.0541
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0028 0.0023
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0079 0.0074
Brugia malayi Serotonin receptor 0.0017 0.0005 0.0005
Brugia malayi glutathione reductase 0.0088 0.0169 0.0169
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0106 0.0211 0.0207
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0035 0.003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0028 0.0023
Loa Loa (eye worm) hhat protein 0.0106 0.0211 0.0207
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0028 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0009 0.0078
Schistosoma mansoni hypothetical protein 0.0106 0.0211 0.0207
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.0672 0.0667
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0047 0.0423
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0106 0.0211 0.0207
Echinococcus multilocularis alpha 1,3 mannosyl glycoprotein 0.0324 0.0723 0.0718
Echinococcus granulosus zinc finger transcription factor gli2 0.0323 0.072 0.0715
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0124 0.0254 0.1933
Brugia malayi hypothetical protein 0.0017 0.0005 0.0005
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0125 0.0255 0.0251
Brugia malayi nuclear receptor NHR-88 0.0027 0.0028 0.0028
Brugia malayi chromobox protein homolog 3 0.0043 0.0064 0.0064
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0106 0.0211 0.0207
Entamoeba histolytica hypothetical protein 0.0077 0.0144 0.6638
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0072 0.0645
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0103 0.1701
Trichomonas vaginalis conserved hypothetical protein 0.033 0.0736 0.6654
Onchocerca volvulus 0.0488 0.1106 0.8667
Leishmania major hypothetical protein, conserved 0.005 0.0081 0.0567
Echinococcus multilocularis snurportin 1 0.0302 0.0672 0.0667
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0081 0.0503
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0002 0.0011
Loa Loa (eye worm) pax transcription factor protein 2 0.052 0.1181 0.1177
Toxoplasma gondii thioredoxin reductase 0.0088 0.0169 0.1115
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.4285 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0028 0.0023
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0013 0.0022
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0028 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0028 0.0028
Trichomonas vaginalis ap endonuclease, putative 0.002 0.001 0.0083
Schistosoma mansoni bromodomain containing protein 0.0132 0.0273 0.0268
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0035 1
Schistosoma mansoni hypothetical protein 0.0023 0.0017 0.0012
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0035 0.0198
Brugia malayi ORL1-like opioid receptor 0.0017 0.0005 0.0005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.0328 0.0328
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0057 0.0511
Echinococcus multilocularis chromobox protein 1 0.0077 0.0143 0.0138
Leishmania major hypothetical protein, conserved 0.004 0.0057 0.0374
Plasmodium vivax thioredoxin reductase, putative 0.0088 0.0169 0.1115
Onchocerca volvulus Huntingtin homolog 0.013 0.0267 0.2066
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0028 0.0023
Echinococcus granulosus cpg binding protein 0.0036 0.0048 0.0044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.0052
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0028 0.0184
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.003 0.0161
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0035 0.6676
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0028 0.0023
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0005 0.0005
Echinococcus granulosus o acyltransferase membrane bound domain 0.0106 0.0211 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0028 0.0023
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.1551 0.1547
Plasmodium falciparum thioredoxin reductase 0.003 0.0035 0.0176
Onchocerca volvulus 0.004 0.0057 0.0412
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0248 0.0545 0.0541

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 5 Binding affinity to PR ChEMBL. 20469868
IC50 (binding) > 5 Binding affinity to AR ChEMBL. 20469868
IC50 (binding) > 5 Activity at GR in human A549 cells by NF-kappaB transrepression assay ChEMBL. 20469868
IC50 (binding) = 5.6 Displacement of fluorescent-labeled Dexamethasone from GR by fluorescent polarization assay ChEMBL. 20469868

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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