Detailed information for compound 1122084

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 303.312 | Formula: C12H21N3O6
  • H donors: 4 H acceptors: 6 LogP: -2.55 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCc1nnn(c1)C[C@H]1O[C@@H](OC)[C@@H]([C@H]([C@H]1O)O)O
  • InChi: 1S/C12H21N3O6/c1-20-12-11(19)10(18)9(17)8(21-12)6-15-5-7(13-14-15)3-2-4-16/h5,8-12,16-19H,2-4,6H2,1H3/t8-,9+,10+,11-,12-/m1/s1
  • InChiKey: PNSGSUPKXZYUEV-YBXAARCKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi ISWI complex protein 0.0016 0.0068 0.01
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0147 0.0256
Trypanosoma brucei phosphoglycerate kinase 0.0176 0.2765 0.5448
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0042 0.0511 0.0511
Leishmania major hypothetical protein, conserved 0.006 0.0805 0.1563
Brugia malayi chromobox protein homolog 3 0.004 0.0481 0.1056
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0313 0.506 1
Echinococcus granulosus phosphoglycerate kinase 1 0.0176 0.2765 0.2765
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0109 0.0239
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0632 0.2012
Loa Loa (eye worm) hypothetical protein 0.0018 0.011 0.024
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0632 0.0632
Schistosoma mansoni chromobox protein 0.0072 0.1014 0.2064
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0951 0.2085
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.015
Schistosoma mansoni voltage-gated cation channel 0.01 0.1475 0.3
Brugia malayi hypothetical protein 0.0068 0.0951 0.2084
Toxoplasma gondii DNA methyltransferase 2, putative 0.002 0.0145 0.0526
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0467 0.1486
Brugia malayi Bromodomain containing protein 0.0033 0.035 0.0768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0129 0.0466
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0428 0.1362
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.0889 0.1729
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0533 0.1169
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0238 0.0485
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0088 0.1275 0.4611
Brugia malayi PHD-finger family protein 0.003 0.0309 0.0678
Onchocerca volvulus 0.0035 0.0385 0.099
Giardia lamblia Sentrin 0.0032 0.0336 0.1046
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0951 0.1934
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0194 0.3058 0.6705
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1446 0.2833
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0616 0.135
Echinococcus multilocularis cpg binding protein 0.0037 0.0418 0.1331
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0238 0.0438
Plasmodium vivax SET domain protein, putative 0.0031 0.0317 0.1145
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0616 0.135
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.1446 0.2833
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0309 0.1118
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0951 0.3109
Echinococcus multilocularis Chromobox protein 3 0.0012 0.000000021434 0.000000068257
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0147 0.0467
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.004 0.0472 0.096
Brugia malayi jmjC domain containing protein 0.0026 0.0238 0.0523
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0238 0.0862
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0194 0.3058 0.6705
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0951 0.0951
Toxoplasma gondii transporter, cation channel family protein 0.0021 0.0152 0.0549
Echinococcus granulosus transcription factor Dp 1 0.004 0.0467 0.0467
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.1473 0.2996
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0176 0.2765 1
Mycobacterium ulcerans glutaminase 0.0283 0.4561 1
Trypanosoma cruzi small ubiquitin protein, putative 0.0032 0.0336 0.0631
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0013 0.0017 0.0063
Loa Loa (eye worm) SMO-1 protein 0.0032 0.0336 0.0736
Toxoplasma gondii hypothetical protein 0.005 0.065 0.235
Toxoplasma gondii hypothetical protein 0.0088 0.1275 0.4611
Entamoeba histolytica hypothetical protein 0.0037 0.0428 0.1399
Loa Loa (eye worm) hypothetical protein 0.0016 0.0074 0.0161
Schistosoma mansoni hypothetical protein 0.0037 0.0428 0.087
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0747 0.0747
Loa Loa (eye worm) hypothetical protein 0.0051 0.0662 0.1451
Echinococcus granulosus voltage dependent calcium channel 0.0021 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0026 0.0238 0.0523
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.1446 0.1446
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0889 0.1729
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0428 0.087
Onchocerca volvulus 0.0042 0.0515 0.1325
Entamoeba histolytica hypothetical protein 0.0037 0.0428 0.1399
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0147 0.0321
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.039 0.0854
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0632 0.1285
Schistosoma mansoni hypothetical protein 0.0013 0.0015 0.003
Echinococcus multilocularis sodium channel protein 0.0042 0.0511 0.1628
Loa Loa (eye worm) hypothetical protein 0.0056 0.0747 0.1638
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.229 0.4507
Loa Loa (eye worm) voltage-dependent calcium channel 0.0021 0.0152 0.0333
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0194 0.3058 0.6705
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0176 0.2765 0.6062
Loa Loa (eye worm) hypothetical protein 0.01 0.1475 0.3233
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0951 0.2085
Echinococcus granulosus cpg binding protein 0.0037 0.0418 0.0418
Loa Loa (eye worm) calcium channel 0.01 0.1475 0.3233
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0129 0.0221
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.01 0.1475 0.4696
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0747 0.1638
Schistosoma mansoni ap endonuclease 0.0019 0.0129 0.0262
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0013 0.0017 0.0038
Loa Loa (eye worm) hypothetical protein 0.0048 0.0613 0.1345
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0662 0.1451
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1446 0.3171
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0012 0.0003 0.0009
Loa Loa (eye worm) glutaminase 2 0.0283 0.4561 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.314 0.314
Echinococcus granulosus lysine specific demethylase 5A 0.0099 0.1473 0.1473
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.1446 0.4729
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0951 0.1851
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0129 0.0221
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.002 0.0145 0.0526
Echinococcus multilocularis zinc finger protein 0.002 0.0142 0.0453
Echinococcus multilocularis lysine specific demethylase 5A 0.0097 0.144 0.4585
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0194 0.3058 1
Brugia malayi PHD-finger family protein 0.0012 0.0001 0.0001
Mycobacterium ulcerans phosphoglycerate kinase 0.0176 0.2765 0.5947
Loa Loa (eye worm) hypothetical protein 0.0021 0.0147 0.0321
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.015
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0632 0.0632
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0632 0.1625
Echinococcus multilocularis chromobox protein 1 0.0072 0.1014 0.3231
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0049 0.0632 0.1386
Loa Loa (eye worm) hypothetical protein 0.0026 0.0238 0.0523
Brugia malayi Phosphoglycerate kinase 0.0176 0.2765 0.6062
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0508 0.1617
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0283 0.062
Entamoeba histolytica hypothetical protein 0.0037 0.0428 0.1399
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.506 1
Echinococcus granulosus DNA methyltransferase 2, putative 0.002 0.0145 0.0145
Trypanosoma brucei phosphoglycerate kinase 0.0176 0.2765 0.5448
Schistosoma mansoni zinc finger protein 0.0016 0.0068 0.0138
Loa Loa (eye worm) hypothetical protein 0.0044 0.0544 0.1193
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0632 0.1285
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.01 0.1475 0.3
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.01 0.1475 0.3233
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0317 0.0644
Echinococcus granulosus peregrin 0.0033 0.035 0.035
Schistosoma mansoni hypothetical protein 0.003 0.0309 0.0629
Brugia malayi Pre-SET motif family protein 0.0214 0.3393 0.7439
Loa Loa (eye worm) hypothetical protein 0.004 0.0481 0.1056
Onchocerca volvulus Alhambra homolog 0.003 0.0309 0.0795
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0747 0.0747
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0147 0.053
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0481 0.1238
Schistosoma mansoni kinase 0.005 0.0637 0.1296
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0272 0.0865
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0074 0.0235
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0074 0.0161
Echinococcus granulosus GPCR family 2 0.0016 0.0074 0.0074
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1446 0.3171
Echinococcus multilocularis disco interacting protein 2 0.004 0.0472 0.1503
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0238 0.0523
Loa Loa (eye worm) glutaminase 0.0283 0.4561 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0147 0.0147
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.1446 0.3718
Leishmania major phosphoglycerate kinase C, glycosomal 0.0176 0.2765 0.5448
Echinococcus multilocularis peregrin 0.0033 0.035 0.1115
Loa Loa (eye worm) hypothetical protein 0.0068 0.0945 0.2071
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.3393 0.7439
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0013 0.0017 0.0063
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0238 0.0523
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0632 0.1386
Mycobacterium ulcerans hypothetical protein 0.0165 0.2571 0.5511
Leishmania major phosphoglycerate kinase B, cytosolic 0.0176 0.2765 0.5448
Trypanosoma cruzi small ubiquitin protein, putative 0.0032 0.0336 0.0631
Echinococcus granulosus zinc finger protein 0.002 0.0142 0.0142
Brugia malayi hypothetical protein 0.0091 0.1336 0.2929
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0194 0.3058 0.6705
Loa Loa (eye worm) hypothetical protein 0.0073 0.1033 0.2264
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.002 0.0145 0.0296
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0161 0.0352
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.016 0.2488 0.2488
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0805 0.1563
Brugia malayi PHD-finger family protein 0.0026 0.0235 0.0516
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0309 0.0984
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.1446 0.3171
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0013 0.0017 0.0063
Trichomonas vaginalis chromobox protein, putative 0.0072 0.1014 0.2224
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0951 0.1851
Trypanosoma brucei polo-like protein kinase 0.0098 0.1446 0.2833
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0309 0.1118
Trypanosoma cruzi ISWI complex protein 0.0016 0.0068 0.01
Echinococcus granulosus disco interacting protein 2 0.004 0.0472 0.0472
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0541 0.1038
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0238 0.0238
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0147 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0481 0.1056
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1446 0.3171
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0033 0.0106
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0129 0.0221
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0317 0.1008
Plasmodium vivax hypothetical protein, conserved 0.003 0.0309 0.1118
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.016 0.2488 0.7923
Schistosoma mansoni DNA helicase recq1 0.0021 0.0147 0.0298
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0176 0.2765 1
Leishmania major mitochondrial DNA polymerase beta 0.0313 0.506 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0541 0.1038
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0147 0.0321
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0317 0.1145
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0129 0.041
Brugia malayi jmjC domain containing protein 0.0026 0.0238 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0481 0.1056
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0176 0.2765 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0309 0.0678
Toxoplasma gondii exonuclease III APE 0.0019 0.0129 0.0466
Plasmodium vivax phosphoglycerate kinase, putative 0.0176 0.2765 1
Brugia malayi Ubiquitin-like protein SMT3 0.0032 0.0336 0.0736
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0238 0.0523
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0033 0.0073
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0194 0.0395
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0176 0.2765 0.5448
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0176 0.2765 0.6062
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0074 0.0235
Brugia malayi glutaminase DH11.1 0.0283 0.4561 1
Loa Loa (eye worm) hypothetical protein 0.004 0.047 0.1029
Schistosoma mansoni jumonji domain containing protein 0.014 0.2146 0.4366
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.1014 0.2224
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1446 0.3171
Loa Loa (eye worm) hypothetical protein 0.0091 0.1336 0.2929
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0065 0.0889 0.1729
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1446 0.3171
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0129 0.0466
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0147 0.0321
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0001
Trypanosoma brucei ISWI complex protein 0.0016 0.0068 0.01
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.229 0.4507
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0533 0.1169
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.002 0.0145 0.0526
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1446 0.3171
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0129 0.0129
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0129 0.0283
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0147 0.0467
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0238 0.0238
Onchocerca volvulus 0.004 0.0472 0.1214
Schistosoma mansoni zinc finger protein 0.002 0.0142 0.0289
Schistosoma mansoni glutaminase 0.0283 0.4561 0.9277
Loa Loa (eye worm) hypothetical protein 0.004 0.0472 0.1035
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.506 1
Trichomonas vaginalis dullard protein, putative 0.0013 0.0017 0.0038
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0013 0.0017 0.0017
Leishmania major hypothetical protein, conserved 0.0016 0.0068 0.01
Trichomonas vaginalis glutaminase, putative 0.0283 0.4561 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0951 0.1851
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0147 0.053
Schistosoma mansoni DNA helicase recq5 0.0021 0.0147 0.0298
Trichomonas vaginalis dullard protein, putative 0.0013 0.0017 0.0038
Echinococcus multilocularis amyloid beta A4 protein 0.0071 0.0997 0.3176
Echinococcus granulosus chromobox protein 1 0.0072 0.1014 0.1014
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0194 0.0194
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0147 0.0424
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.2571 0.9266
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0017 0.0038
Brugia malayi Pre-SET motif family protein 0.0031 0.0317 0.0694
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0064 0.0871 0.191
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0038
Giardia lamblia Phosphoglycerate kinase 0.0176 0.2765 0.9035
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.015
Schistosoma mansoni eyes absent homolog 0.0091 0.1336 0.2717
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0309 0.0678
Loa Loa (eye worm) hypothetical protein 0.0091 0.1336 0.2929
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0194 0.3058 0.6705
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0541 0.1038
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0013 0.0017 0.0056
Echinococcus granulosus voltage dependent calcium channel 0.01 0.1475 0.1475
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0951 0.3028
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0703 0.1359
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0194 0.3058 1
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0012 0.0003 0.0006
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0541 0.1038
Brugia malayi jmjC domain containing protein 0.016 0.2488 0.5455
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0147 0.0321
Brugia malayi CXXC zinc finger family protein 0.0035 0.0385 0.0844
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0129 0.0422
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0194 0.3058 0.6705
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.1446 0.3171
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0272 0.0272
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0238 0.0485
Echinococcus granulosus bloom syndrome protein 0.0021 0.0147 0.0147
Echinococcus multilocularis phosphoglycerate kinase 1 0.0176 0.2765 0.8804
Echinococcus granulosus CTD small phosphatase protein like 0.0013 0.0017 0.0017
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.0238 0.0862
Entamoeba histolytica ubiquitin like protein 0.0032 0.0336 0.1097
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0147 0.053
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0147 0.0147
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0841 0.2678
Brugia malayi mbt repeat family protein 0.0049 0.0632 0.1386
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0147 0.0467
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0238 0.0238
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0129 0.0283
Loa Loa (eye worm) hypothetical protein 0.0042 0.0511 0.112
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0385 0.0844
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.085 0.1863
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.314 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.01 0.1475 0.3
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0017 0.0038
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0134 0.2054 0.7305
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0033
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0098 0.02
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0889 0.1729
Loa Loa (eye worm) hypothetical protein 0.0068 0.0951 0.2084
Entamoeba histolytica hypothetical protein 0.0037 0.0428 0.1399
Onchocerca volvulus 0.0032 0.0335 0.086
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0194 0.3058 0.6609
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.01 0.1475 0.1475
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0298 0.0298
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0194 0.3058 0.6705
Plasmodium falciparum phd finger protein, putative 0.003 0.0309 0.1118
Loa Loa (eye worm) hypothetical protein 0.0018 0.011 0.024
Brugia malayi Protein-tyrosine phosphatase 1 0.0012 0.0003 0.0006
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0017 0.0036
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0194 0.3058 0.6705
Schistosoma mansoni bromodomain containing protein 0.0066 0.0903 0.1837
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0032 0.0336 0.0683
Schistosoma mansoni phosphoglycerate kinase 0.0176 0.2765 0.5624
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0012 0.0003 0.0003
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0238 0.0759
Echinococcus multilocularis DNA methyltransferase 2, putative 0.002 0.0145 0.0463
Schistosoma mansoni phosphoglycerate kinase 0.0176 0.2765 0.5624
Trypanosoma brucei phosphoglycerate kinase 0.0065 0.0889 0.1729
Trypanosoma brucei small ubiquitin-related modifier 0.0032 0.0336 0.0631
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0176 0.2765 1
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.1446 0.2941
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.0889 0.1729
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0074 0.0161
Trichomonas vaginalis dullard protein, putative 0.0013 0.0017 0.0038
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0508 0.0508
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.006 0.0805 0.1766
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.002 0.0145 0.0526
Loa Loa (eye worm) hypothetical protein 0.0032 0.0335 0.0733
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0613 0.1248
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0515 0.1048
Schistosoma mansoni hypothetical protein 0.0021 0.0161 0.0327
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0194 0.0618
Echinococcus multilocularis voltage dependent calcium channel 0.01 0.1475 0.4696
Brugia malayi Phosphoglycerate kinase 0.0065 0.0889 0.195
Plasmodium vivax small ubiquitin-related modifier, putative 0.0032 0.0336 0.1214
Brugia malayi Bromodomain containing protein 0.004 0.0468 0.1027
Echinococcus multilocularis voltage dependent calcium channel 0.01 0.1475 0.4696
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0194 0.3058 1
Schistosoma mansoni amyloid beta A4 protein related 0.0071 0.0997 0.2029
Echinococcus granulosus phd:f box containing protein 0.0026 0.0238 0.0238
Echinococcus granulosus chromobox protein 1 0.0072 0.1014 0.1014
Brugia malayi Disco-interacting protein 2 homolog 0.004 0.0472 0.1035
Chlamydia trachomatis phosphoglycerate kinase 0.0176 0.2765 0.5
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.1446 0.4605
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.01 0.1475 0.1475
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.01 0.1475 0.4696
Loa Loa (eye worm) RecQ helicase 0.0021 0.0147 0.0321
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.01 0.1475 0.4696
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0176 0.2765 1
Trichomonas vaginalis set domain proteins, putative 0.0243 0.3889 0.8527
Treponema pallidum phosphoglycerate kinase 0.0176 0.2765 1
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0147 0.0479
Brugia malayi Heterochromatin protein 1 0.0072 0.1014 0.2224
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0098 0.0098
Plasmodium falciparum small ubiquitin-related modifier 0.0032 0.0336 0.1214
Echinococcus granulosus Small ubiquitin modifier 2 0.0032 0.0336 0.0336
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0013 0.0017 0.0057
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0662 0.1451
Schistosoma mansoni cpg binding protein 0.0035 0.0385 0.0783
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.1473 0.2996
Trypanosoma brucei phosphoglycerate kinase, putative 0.0065 0.0889 0.1729
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0238 0.0485
Plasmodium falciparum phosphoglycerate kinase 0.0176 0.2765 1
Echinococcus multilocularis chromobox protein 1 0.0072 0.1014 0.3231
Loa Loa (eye worm) hypothetical protein 0.0035 0.039 0.0854
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0238 0.0759
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0613 0.0613
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.002 0.0145 0.0254
Schistosoma mansoni ap endonuclease 0.0019 0.0129 0.0262
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0238 0.0438
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0098 0.02
Schistosoma mansoni chromobox protein 0.0072 0.1014 0.2064
Schistosoma mansoni cpg binding protein 0.0037 0.0418 0.085
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0283 0.062
Giardia lamblia PHD finger protein 15 0.003 0.0309 0.0959
Brugia malayi jmjC domain containing protein 0.0099 0.1473 0.323
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0238 0.0485
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0176 0.2765 0.5448
Loa Loa (eye worm) jmjC domain-containing protein 0.0099 0.1473 0.323
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.002 0.0145 0.0475
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0428 0.0428
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0427 0.136
Brugia malayi jmjC domain containing protein 0.0026 0.0238 0.0523
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0238 0.0759
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0632 0.1285
Onchocerca volvulus 0.0049 0.0632 0.1625
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0061 0.0819 0.159
Brugia malayi mbt repeat family protein 0.0049 0.0632 0.1386
Echinococcus granulosus Chromobox protein 3 0.0012 0.000000021434 0.000000021434
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1446 0.2833
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0805 0.1563
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0613 0.1248
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0427 0.0427
Toxoplasma gondii small ubiquitin family modifier, putative 0.0032 0.0336 0.1214
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0238 0.0759
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0017 0.0038
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0098 0.0313
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0147 0.0321
Schistosoma mansoni hypothetical protein 0.0035 0.039 0.0792
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.002 0.0043
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0747 0.1519
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0017 0.0038
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.01 0.1475 0.4696
Loa Loa (eye worm) X11 protein 0.0071 0.0997 0.2187
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0074 0.0161
Brugia malayi jmjC domain containing protein 0.0026 0.0238 0.0523
Brugia malayi Bromodomain containing protein 0.0078 0.1107 0.2428
Leishmania major small ubiquitin protein, putative 0.0032 0.0336 0.0631
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0238 0.0485
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0632 0.2012
Trichomonas vaginalis chromobox protein, putative 0.0072 0.1014 0.2224
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0336 0.0736
Echinococcus multilocularis GPCR, family 2 0.0016 0.0074 0.0235
Echinococcus multilocularis Small ubiquitin modifier 2 0.0032 0.0336 0.1069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0333
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0662 0.1451
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0147 0.0321
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0013 0.0017 0.0063
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.01 0.1475 0.1475
Schistosoma mansoni hypothetical protein 0.0304 0.4916 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.2765 0.6062
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0074 0.0074
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0017 0.0036
Leishmania major modification methylase-like protein 0.002 0.0145 0.0254
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.006 0.0805 0.1563
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.006 0.0805 0.1766
Toxoplasma gondii hypothetical protein 0.0018 0.011 0.0396
Brugia malayi hypothetical protein 0.0037 0.0428 0.0938
Leishmania major hypothetical protein, conserved 0.0026 0.0238 0.0438
Onchocerca volvulus 0.0243 0.3889 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0951 0.1851
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0533 0.1371
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0074 0.0074
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0238 0.0438
Schistosoma mansoni cpg binding protein 0.0037 0.0418 0.085
Brugia malayi CHD4 protein 0.0014 0.0033 0.0073
Entamoeba histolytica phosphoglycerate kinase, putative 0.0176 0.2765 0.904
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0889 0.1729
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.229 0.4507
Giardia lamblia Kinase, PLK 0.0098 0.1446 0.4698
Brugia malayi SET domain containing protein 0.0013 0.0019 0.0042
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0129 0.0221
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0747 0.2378
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0147 0.053
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0129 0.0283
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.0238 0.0862
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0129 0.0283
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0309 0.0629
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0129 0.0366
Echinococcus multilocularis 0.0013 0.0017 0.0056
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0841 0.0841
Loa Loa (eye worm) MBCTL1 0.0056 0.0747 0.1638
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0747 0.2378
Onchocerca volvulus 0.0194 0.3058 0.7864
Schistosoma mansoni hypothetical protein 0.0016 0.0074 0.015
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0147 0.0256
Plasmodium vivax JmjC domain containing protein 0.0026 0.0238 0.0862
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1446 0.3171
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0613 0.1954
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0147 0.0256
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0033 0.0068
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0061 0.0819 0.159
Echinococcus granulosus amyloid beta A4 protein 0.0071 0.0997 0.0997
Schistosoma mansoni hypothetical protein 0.0016 0.0068 0.0138

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.