Detailed information for compound 1122259

Basic information

Technical information
  • TDR Targets ID: 1122259
  • Name: [2-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethylam ino]-2-oxoethyl] 3-furan-2-ylprop-2-enoate
  • MW: 338.336 | Formula: C14H14N2O6S
  • H donors: 1 H acceptors: 4 LogP: 0.67 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COC(=O)/C=C/c1ccco1)NCCN1C(=O)CSC1=O
  • InChi: 1S/C14H14N2O6S/c17-11(15-5-6-16-12(18)9-23-14(16)20)8-22-13(19)4-3-10-2-1-7-21-10/h1-4,7H,5-6,8-9H2,(H,15,17)/b4-3+
  • InChiKey: BTANMEXGGYZNBA-ONEGZZNKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethylamino]-2-oxoethyl] (E)-3-furan-2-ylprop-2-enoate
  • [2-[2-(2,4-dioxothiazolidin-3-yl)ethylamino]-2-oxo-ethyl] (E)-3-(2-furyl)prop-2-enoate
  • [2-[2-(2,4-dioxothiazolidin-3-yl)ethylamino]-2-oxo-ethyl] 3-(2-furyl)prop-2-enoate
  • (E)-3-(2-furyl)prop-2-enoic acid [2-[2-(2,4-dioxo-3-thiazolidinyl)ethylamino]-2-oxoethyl] ester
  • 3-(2-furyl)prop-2-enoic acid [2-[2-(2,4-dioxo-3-thiazolidinyl)ethylamino]-2-oxoethyl] ester
  • (E)-3-(2-furyl)acrylic acid [2-[2-(2,4-diketothiazolidin-3-yl)ethylamino]-2-keto-ethyl] ester
  • 3-(2-furyl)acrylic acid [2-[2-(2,4-diketothiazolidin-3-yl)ethylamino]-2-keto-ethyl] ester
  • [2-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethylamino]-2-oxo-ethyl] 3-furan-2-ylprop-2-enoate
  • [2-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethylamino]-2-oxo-ethyl] (E)-3-furan-2-ylprop-2-enoate
  • MLS001005493
  • SMR000383972
  • ZINC03297851
  • T0515-4427

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi glutaminase DH11.1 0.0264 0.661 0.8458
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0856 0.115
Brugia malayi ImpB/MucB/SamB family protein 0.0051 0.1106 0.1415
Trypanosoma cruzi DNA polymerase kappa, putative 0.0077 0.177 0.2401
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0065 0.0055
Schistosoma mansoni hypothetical protein 0.002 0.0295 0.0295
Mycobacterium ulcerans hypothetical protein 0.0154 0.3755 0.5663
Loa Loa (eye worm) hypothetical protein 0.0017 0.0223 0.0285
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.3347 0.8224
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0029 0.0029
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0175 0.0433
Toxoplasma gondii casein kinase I 0.0074 0.1684 0.4176
Toxoplasma gondii hypothetical protein 0.0047 0.0997 0.2473
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0904 0.1244
Giardia lamblia PHD finger protein 15 0.0028 0.0508 0.0718
Schistosoma mansoni protein phosphatase 2C 0.0009 0.0015 0.0015
Echinococcus granulosus muscleblind protein 0.0144 0.3512 0.3512
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1329 0.1329
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0859 0.1155
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0029 0.0029
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0312 0.04
Loa Loa (eye worm) hypothetical protein 0.0076 0.1742 0.223
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0065 0.0068
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0904 0.2213
Echinococcus multilocularis dna polymerase eta 0.0076 0.1742 0.1742
Echinococcus granulosus geminin 0.0164 0.4014 0.4014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0223 0.0285
Loa Loa (eye worm) hypothetical protein 0.0037 0.0739 0.0945
Leishmania major phosphoglycerate kinase B, cytosolic 0.0164 0.4032 0.5495
Brugia malayi SET domain containing protein 0.0013 0.0108 0.0138
Mycobacterium ulcerans DNA polymerase IV 0.0077 0.177 0.2649
Loa Loa (eye worm) hypothetical protein 0.0017 0.0223 0.0285
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0018 0.0004
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.041 0.054
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0065 0.0055
Echinococcus granulosus casein kinase I delta 0.0074 0.1684 0.1684
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0033
Trichomonas vaginalis chromobox protein, putative 0.0041 0.083 0.1139
Loa Loa (eye worm) hypothetical protein 0.0017 0.0223 0.0285
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0313 0.0407
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0508 0.0508
Echinococcus granulosus cpg binding protein 0.0031 0.0586 0.0586
Echinococcus multilocularis dna polymerase kappa 0.0077 0.177 0.177
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.7083 1
Onchocerca volvulus 0.0011 0.0065 0.0068
Loa Loa (eye worm) hypothetical protein 0.0024 0.041 0.0524
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0384 0.0384
Trypanosoma cruzi ISWI complex protein 0.0015 0.0162 0.0201
Schistosoma mansoni chromobox protein 0.0011 0.0065 0.0065
Schistosoma mansoni cpg binding protein 0.0028 0.0497 0.0497
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.1284 0.1643
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0756 0.1283
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0514 0.1217
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0033
Echinococcus granulosus hypothetical protein 0.0026 0.046 0.046
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.075 0.075
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0074 0.1684 0.2283
Echinococcus granulosus casein kinase I alpha 0.0074 0.1684 0.1684
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0046 0.0968 0.1238
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0062 0.0062
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.075 0.096
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0065 0.0055
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0508 0.1228
Echinococcus granulosus phosphoglycerate kinase 1 0.0164 0.4032 0.4032
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.7083 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0065 0.0055
Loa Loa (eye worm) hypothetical protein 0.0048 0.1029 0.1316
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0021
Schistosoma mansoni bromodomain containing protein 0.0066 0.1491 0.1491
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0227 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0065 0.0055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0077 0.177 0.2401
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0065 0.0083
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0175 0.0218
Trichomonas vaginalis chromobox protein, putative 0.0067 0.1521 0.2118
Onchocerca volvulus 0.001 0.005 0.0043
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.2166 0.2166
Mycobacterium tuberculosis Conserved hypothetical protein 0.0051 0.1106 0.2414
Brugia malayi Growth-Arrest-Specific Protein 2 Domain containing protein 0.0034 0.0661 0.0846
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.1401 0.1401
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0372 0.0512
Echinococcus granulosus lysine specific demethylase 6a 0.0009 0.0015 0.0015
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0065 0.0161
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0756 0.1035
Loa Loa (eye worm) hypothetical protein 0.0016 0.0205 0.0263
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.1684 0.1684
Plasmodium vivax casein kinase 1, putative 0.0074 0.1684 0.4154
Loa Loa (eye worm) hypothetical protein 0.0023 0.0372 0.0476
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.5688 0.5688
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0065 0.0065
Schistosoma mansoni cpg binding protein 0.0031 0.0586 0.0586
Schistosoma mansoni hypothetical protein 0.0011 0.0062 0.0062
Brugia malayi Protein cec-1. 0.0011 0.0065 0.0083
Loa Loa (eye worm) hypothetical protein 0.003 0.0545 0.0697
Echinococcus multilocularis casein kinase I alpha 0.0074 0.1684 0.1684
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.041 0.1016
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0904 0.2242
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.008 0.1849 0.1849
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0073 0.1661 0.2251
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0372 0.0476
Brugia malayi Bromodomain containing protein 0.0077 0.1784 0.2282
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0015 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0372 0.0526
Schistosoma mansoni cpg binding protein 0.0031 0.0586 0.0586
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.2496 0.3194
Echinococcus granulosus chromobox protein 1 0.0067 0.1521 0.1521
Loa Loa (eye worm) hypothetical protein 0.0228 0.5688 0.7279
Schistosoma mansoni DNA ligase IV 0.001 0.0026 0.0026
Brugia malayi casein kinase I 0.0074 0.1684 0.2155
Loa Loa (eye worm) helicase 0.0011 0.0065 0.0083
Echinococcus multilocularis Chromo domain 0.0011 0.0065 0.0065
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0313 0.0401
Plasmodium falciparum casein kinase 1 0.0074 0.1684 0.4176
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0793 0.1966
Loa Loa (eye worm) hypothetical protein 0.0026 0.046 0.0588
Schistosoma mansoni hypothetical protein 0.0026 0.046 0.046
Brugia malayi hypothetical protein 0.0035 0.0694 0.0889
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0508 0.0508
Echinococcus granulosus JmjC domain containing protein 4 0.0009 0.0015 0.0015
Brugia malayi topoisomerase 0.001 0.0026 0.0033
Schistosoma mansoni hypothetical protein 0.0026 0.046 0.046
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0026 0.0026
Loa Loa (eye worm) phosphofructokinase 0.0105 0.2496 0.3194
Giardia lamblia Replication factor C, subunit 1 0.001 0.0026 0.0037
Onchocerca volvulus 0.0023 0.0372 0.0609
Brugia malayi jmjC domain containing protein 0.0038 0.075 0.096
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.2496 0.35
Schistosoma mansoni DNA polymerase IV / kappa 0.0016 0.0191 0.0191
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0793 0.1014
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0039 0.0793 0.1966
Onchocerca volvulus Deterin homolog 0.0052 0.1132 0.1945
Brugia malayi hypothetical protein 0.0026 0.046 0.0588
Schistosoma mansoni zinc finger protein 0.0024 0.0399 0.0399
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0662 0.0662
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0223 0.0517
Trypanosoma brucei phosphoglycerate kinase 0.0164 0.4032 0.5495
Entamoeba histolytica deoxycytidyl transferase, putative 0.0051 0.1106 0.1531
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0065 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0859 0.1155
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0198 0.0061
Schistosoma mansoni topbp1 0.001 0.0026 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.177 0.2401
Echinococcus multilocularis zinc finger protein 0.0024 0.0399 0.0399
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0164 0.4032 0.5678
Loa Loa (eye worm) hypothetical protein 0.0164 0.4032 0.516
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0009 0.0015 0.0037
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.3347 0.829
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.2496 0.2496
Chlamydia trachomatis phosphoglycerate kinase 0.0164 0.4032 1
Schistosoma mansoni hypothetical protein 0.0011 0.0065 0.0065
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0058 0.1271 0.1718
Schistosoma mansoni hypothetical protein 0.008 0.1849 0.1849
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.177 0.2401
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0968 0.0968
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0372 0.0512
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0372 0.0491
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0065 0.0055
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0051 0.1106 0.1415
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0541 0.0541
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0313 0.0313
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0198 0.0061
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.041 0.054
Schistosoma mansoni hypothetical protein 0.0034 0.0661 0.0661
Schistosoma mansoni terminal deoxycytidyl transferase 0.0051 0.1106 0.1106
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0372 0.0526
Giardia lamblia Kinase, CK1 Casein kinase 0.0074 0.1684 0.2378
Trichomonas vaginalis chromobox protein, putative 0.0067 0.1521 0.2118
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0227 0.0286
Schistosoma mansoni protein kinase 0.0074 0.1684 0.1684
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0175 0.0433
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0794 0.0794
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0508 0.065
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0065 0.0065
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0051 0.1106 0.1106
Echinococcus multilocularis muscleblind protein 0.0144 0.3512 0.3512
Mycobacterium ulcerans DNA polymerase IV 0.0077 0.177 0.2649
Mycobacterium ulcerans hypothetical protein 0.0016 0.0191 0.0251
Trypanosoma cruzi casein kinase, putative 0.0074 0.1684 0.2283
Loa Loa (eye worm) glutaminase 2 0.0264 0.661 0.8458
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0198 0.0061
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0514 0.1217
Echinococcus granulosus bloom syndrome protein 0.0021 0.0313 0.0313
Onchocerca volvulus 0.0074 0.1684 0.2915
Trypanosoma cruzi phosphoglycerate kinase, putative 0.006 0.1341 0.1814
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0026 0.0064
Echinococcus granulosus inhibitor of apoptosis protein 0.0052 0.1132 0.1132
Echinococcus multilocularis cpg binding protein 0.0031 0.0586 0.0586
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0051 0.1106 0.1106
Echinococcus multilocularis JmjC domain containing protein 4 0.0009 0.0015 0.0015
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.2496 0.35
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0065 0.0065
Leishmania major casein kinase, putative 0.0074 0.1684 0.2283
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0175 0.0218
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0372 0.0476
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0065 0.0083
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0191 0.0241
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0191 0.0241
Onchocerca volvulus 0.0052 0.1132 0.1945
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0191 0.0241
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0065 0.0083
Loa Loa (eye worm) hypothetical protein 0.0034 0.0661 0.0846
Echinococcus multilocularis phd:f box containing protein 0.0009 0.0015 0.0015
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0074 0.1684 0.2155
Echinococcus multilocularis casein kinase I delta 0.0074 0.1684 0.1684
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0372 0.0476
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0227 0.0286
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.7083 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0175 0.0397
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0514 0.0691
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0514 0.1241
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0009 0.0015 0.0037
Trypanosoma cruzi casein kinase, putative 0.0074 0.1684 0.2283
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.2496 0.3194
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0295 0.0378
Echinococcus granulosus chromobox protein 1 0.0067 0.1521 0.1521
Brugia malayi isocitrate dehydrogenase 0.0015 0.0175 0.0223
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0062 0.0153
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.041 0.1016
Schistosoma mansoni hypothetical protein 0.0009 0.0018 0.0018
Echinococcus multilocularis protein quaking 0.0026 0.046 0.046
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.2496 0.2496
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0077 0.177 0.2472
Loa Loa (eye worm) hypothetical protein 0.0046 0.0975 0.1248
Schistosoma mansoni hypothetical protein 0.0015 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0083
Schistosoma mansoni chromobox protein 0.0067 0.1521 0.1521
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0052 0.1132 0.1132
Schistosoma mansoni survival motor neuron protein 0.0047 0.0985 0.0985
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0206 0.0206
Trypanosoma cruzi DNA polymerase kappa, putative 0.0077 0.177 0.2401
Schistosoma mansoni phd/f-box containing protein 0.0009 0.0015 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.177 0.2401
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0065 0.0161
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.041 0.054
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.177 0.2401
Onchocerca volvulus 0.0073 0.1661 0.2874
Echinococcus multilocularis geminin 0.0164 0.4014 0.4014
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0065 0.0055
Entamoeba histolytica casein kinase, putative 0.0074 0.1684 0.235
Brugia malayi Phosphoglycerate kinase 0.006 0.1341 0.1716
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.006 0.1341 0.1814
Echinococcus granulosus Chromobox protein 3 0.0011 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0083
Loa Loa (eye worm) histone methyltransferase 0.001 0.0029 0.0038
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.041 0.0982
Loa Loa (eye worm) bromodomain containing protein 0.002 0.031 0.0397
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0904 0.2242
Brugia malayi jmjC domain containing protein 0.0009 0.0015 0.0019
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0164 0.4032 1
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.2496 0.35
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0083
Schistosoma mansoni jumonji domain containing protein 0.0009 0.0015 0.0015
Onchocerca volvulus 0.003 0.0545 0.0912
Trypanosoma cruzi ISWI complex protein 0.0015 0.0162 0.0201
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0793 0.0793
Trypanosoma cruzi DNA polymerase kappa, putative 0.0077 0.177 0.2401
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0198 0.0061
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0514 0.0691
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0065 0.0055
Leishmania major hypothetical protein, conserved 0.0015 0.0162 0.0201
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.083 0.1413
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.2496 0.2496
Brugia malayi hypothetical protein 0.001 0.0026 0.0033
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0026 0.0015
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0678 0.0678
Trypanosoma brucei DNA polymerase IV, putative 0.0071 0.1606 0.2175
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0856 0.115
Trichomonas vaginalis chromobox protein, putative 0.0041 0.083 0.1139
Entamoeba histolytica phosphoglycerate kinase, putative 0.0164 0.4032 0.5678
Plasmodium vivax phosphoglycerate kinase, putative 0.0164 0.4032 1
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0052 0.1132 0.1132
Loa Loa (eye worm) hypothetical protein 0.0038 0.0756 0.0967
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0026 0.0026
Leishmania major DNA polymerase eta, putative 0.0041 0.0828 0.1112
Loa Loa (eye worm) tumor suppressor 0.0311 0.7815 1
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.1521 0.1946
Brugia malayi Pre-SET motif family protein 0.0202 0.4996 0.6392
Leishmania major phosphoglycerate kinase C, glycosomal 0.0164 0.4032 0.5495
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0372 0.0526
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.2496 0.35
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0104 0.0104
Plasmodium falciparum DNA repair protein REV1, putative 0.0016 0.0191 0.0475
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0223 0.0124
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0175 0.0433
Onchocerca volvulus 0.0011 0.0065 0.0068
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0065 0.0124
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1315 0.326
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0514 0.0691
Trypanosoma brucei unspecified product 0.0035 0.0694 0.0929
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0065 0.0055
Brugia malayi hypothetical protein 0.0024 0.041 0.0524
Brugia malayi 6-phosphofructokinase 0.0105 0.2496 0.3194
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0191 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0471 0.063
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.2496 0.35
Brugia malayi Heterochromatin protein 1 0.0067 0.1521 0.1946
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0227 0.0286
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0227 0.0286
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0227 0.0286
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0372 0.0526
Echinococcus granulosus Spectrin alpha actinin 0.0034 0.0661 0.0661
Plasmodium vivax DNA repair protein REV1, putative 0.0016 0.0191 0.0439
Leishmania major DNA polymerase eta, putative 0.0076 0.1742 0.2363
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0065 0.0055
Trypanosoma brucei ISWI complex protein 0.0015 0.0162 0.0201
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.3755 0.928
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.7083 1
Schistosoma mansoni hypothetical protein 0.0034 0.0661 0.0661
Loa Loa (eye worm) hypothetical protein 0.0023 0.0372 0.0476
Echinococcus granulosus jumonji domain containing 1A 0.0009 0.0015 0.0015
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.7326 1
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0514 0.0691
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0065 0.0124
Echinococcus granulosus peregrin 0.0034 0.0656 0.0656
Brugia malayi 6-phosphofructokinase 0.0105 0.2496 0.3194
Schistosoma mansoni inhibitor of apoptosis protein 0.0052 0.1132 0.1132
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0083
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0065 0.0068
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0372 0.0865
Brugia malayi PHD-finger family protein 0.0013 0.0107 0.0136
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0826 0.0826
Trypanosoma cruzi casein kinase, putative 0.0074 0.1684 0.2283
Echinococcus granulosus nibrin 0.001 0.0026 0.0026
Brugia malayi DKFZp564C0469 protein 0.001 0.0026 0.0033
Loa Loa (eye worm) hypothetical protein 0.0039 0.0793 0.1014
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0175 0.0175
Brugia malayi Muscleblind-like protein 0.0144 0.3512 0.4494
Trichomonas vaginalis CK1 family protein kinase 0.0074 0.1684 0.235
Echinococcus multilocularis chromobox protein 1 0.0067 0.1521 0.1521
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0033
Plasmodium falciparum JmjC domain-containing protein, putative 0.0009 0.0015 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.177 0.2401
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0372 0.0526
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0153 0.0196
Echinococcus granulosus casein kinase I alpha 0.0074 0.1684 0.1684
Schistosoma mansoni hypothetical protein 0.0164 0.4014 0.4014
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0065 0.0065
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0016 0.0191 0.0475
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.008 0.1849 0.1849
Schistosoma mansoni topbp1 0.001 0.0026 0.0026
Onchocerca volvulus 0.0028 0.0497 0.0829
Giardia lamblia Phosphoglycerate kinase 0.0164 0.4032 0.5693
Schistosoma mansoni hypothetical protein 0.0164 0.4014 0.4014
Schistosoma mansoni jumonji domain containing protein 0.0073 0.1675 0.1675
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.075 0.075
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0201 0.0201
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0026 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.177 0.2401
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.2496 0.2496
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0841 0.113
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0033
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0841 0.113
Loa Loa (eye worm) hypothetical protein 0.0144 0.3512 0.4494
Trichomonas vaginalis set domain proteins, putative 0.0229 0.5714 0.8061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.014 0.0162
Echinococcus granulosus dna polymerase eta 0.0076 0.1742 0.1742
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0026 0.0033
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0026 0.0064
Leishmania major hypothetical protein, conserved 0.0024 0.041 0.054
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0175 0.0175
Brugia malayi jmjC domain containing protein 0.0009 0.0015 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.7083 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.1401 0.1401
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0175 0.0175
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0175 0.0175
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0065 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.1271 0.1718
Trypanosoma cruzi DNA polymerase eta, putative 0.0076 0.1742 0.2363
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0083
Brugia malayi Bromodomain containing protein 0.0034 0.0656 0.084
Brugia malayi hypothetical protein 0.0016 0.0187 0.0239
Echinococcus multilocularis chromobox protein 1 0.0067 0.1521 0.1521
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0514 0.0691
Echinococcus granulosus casein kinase i 0.0074 0.1684 0.1684
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.006 0.1341 0.1814
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0223 0.0491
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0372 0.0489
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.2496 0.6165
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0164 0.4032 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0498 0.0498
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0968 0.0968
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0065 0.0055
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.5688 0.5688
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0191 0.0241
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0372 0.0526
Brugia malayi hypothetical protein 0.0011 0.0065 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0026 0.0015
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0372 0.0865
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0009 0.0018 0.0045
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.4996 0.6392
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0372 0.0526
Brugia malayi jmjC domain containing protein 0.0009 0.0015 0.0019
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0175 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0065 0.0055
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0372 0.0489
Brugia malayi hypothetical protein 0.001 0.0026 0.0033
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0164 0.4032 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0508 0.0508
Trypanosoma cruzi kinetoplast DNA-associated protein, putative 0.0034 0.0661 0.0884
Schistosoma mansoni hypothetical protein 0.008 0.1849 0.1849
Trypanosoma brucei DNA polymerase IV, putative 0.0077 0.177 0.2401
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0248 0.0616
Brugia malayi tumor suppressor. 0.0311 0.7815 1
Giardia lamblia DINP protein human, muc B family 0.0058 0.1271 0.1794
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0191 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0065 0.0055
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.7326 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0541 0.1343
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0514 0.0691
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0083
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0065 0.0124
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0313 0.0407
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0136 0.0338
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0756 0.1068
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0793 0.1014
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.2496 0.3393
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0514 0.1241
Onchocerca volvulus Alhambra homolog 0.0028 0.0508 0.0848
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0175 0.0175
Schistosoma mansoni phosphoglycerate kinase 0.0164 0.4032 0.4032
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0065 0.0161
Echinococcus granulosus phd:f box containing protein 0.0009 0.0015 0.0015
Mycobacterium ulcerans glutaminase 0.0264 0.661 1
Trypanosoma brucei casein kinase I, isoform 2 0.0074 0.1684 0.2283
Echinococcus multilocularis muscleblind protein 1 0.0144 0.3512 0.3512
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0227 0.0286
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.2166 0.2166
Loa Loa (eye worm) glutaminase 0.0264 0.661 0.8458
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0841 0.113
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0153 0.0153
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0065 0.0068
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0175 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.177 0.2401
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0015 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.7083 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.041 0.1016
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0009 0.0015 0.0015
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0052 0.1132 0.1449
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0065 0.0161
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0514 0.0691
Loa Loa (eye worm) RecQ helicase 0.0021 0.0313 0.0401
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.7326 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.3351 0.4563
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0022 0.0356 0.0884
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0968 0.0968
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0175 0.0223
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0191 0.0241
Echinococcus granulosus casein kinase I delta 0.0074 0.1684 0.1684
Brugia malayi hypothetical protein 0.0035 0.0694 0.0889
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0175 0.0218
Brugia malayi PHD-finger family protein 0.0028 0.0508 0.065
Toxoplasma gondii PHD-finger domain-containing protein 0.0009 0.0018 0.0045
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0372 0.0491
Brugia malayi CHD4 protein 0.0014 0.0153 0.0196
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0074 0.1684 0.2155
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0508 0.1261
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0175 0.0218
Trichomonas vaginalis CK1 family protein kinase 0.0074 0.1684 0.235
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0104 0.0104
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0224 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0065 0.0055
Trypanosoma brucei phosphoglycerate kinase 0.0164 0.4032 0.5495
Schistosoma mansoni phosphoglycerate kinase 0.0164 0.4032 0.4032
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.177 0.2401
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.33 0.33
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0164 0.4032 0.5495
Schistosoma mansoni apoptosis regulator bax 0.008 0.1849 0.1849
Echinococcus multilocularis peregrin 0.0034 0.0656 0.0656
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0514 0.0691
Loa Loa (eye worm) hypothetical protein 0.0068 0.1547 0.1979
Onchocerca volvulus 0.0047 0.0985 0.1686
Loa Loa (eye worm) apoptosis regulator protein 0.008 0.1849 0.2366
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0756 0.1875
Schistosoma mansoni DNA polymerase eta 0.0076 0.1742 0.1742
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.2496 0.35
Echinococcus multilocularis lysine specific demethylase 6a 0.0009 0.0015 0.0015
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0074 0.1684 0.2155
Mycobacterium ulcerans hypothetical protein 0.0023 0.0372 0.0526
Brugia malayi polk-prov protein 0.0042 0.0856 0.1095
Plasmodium vivax SET domain protein, putative 0.0029 0.0541 0.131
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.7083 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0497 0.0637
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.3461 0.3461
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.3461 0.4428
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0756 0.1034
Trichomonas vaginalis glutaminase, putative 0.0264 0.661 0.933
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.3347 0.5044
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0065 0.0161
Loa Loa (eye worm) hypothetical protein 0.008 0.1849 0.2366
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0678 0.0678
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0026 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0756 0.1034
Trypanosoma brucei DNA polymerase kappa, putative 0.0077 0.177 0.2401
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.3351 0.4563
Echinococcus multilocularis casein kinase I delta 0.0074 0.1684 0.1684
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0033
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0904 0.1244
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0065 0.0065
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.2496 0.3751
Echinococcus granulosus casein kinase I alpha 0.0074 0.1684 0.1684
Entamoeba histolytica hypothetical protein 0.0011 0.0065 0.0055
Trichomonas vaginalis CK1 family protein kinase 0.0074 0.1684 0.235
Echinococcus multilocularis casein kinase i 0.0074 0.1684 0.1684
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0794 0.0794
Schistosoma mansoni hypothetical protein 0.0052 0.1132 0.1132
Schistosoma mansoni bromodomain containing protein 0.0009 0.0016 0.0016
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0052 0.1132 0.1132
Loa Loa (eye worm) hypothetical protein 0.0144 0.3512 0.4494
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0164 0.4032 1
Plasmodium falciparum phosphoglycerate kinase 0.0164 0.4032 1
Trypanosoma brucei phosphoglycerate kinase 0.006 0.1341 0.1814
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.1073 0.1447
Trypanosoma brucei DNA polymerase eta, putative 0.0076 0.1742 0.2363
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0028 0.0508 0.065
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0223 0.0299
Entamoeba histolytica casein kinase 1, putative 0.0074 0.1684 0.235
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0051 0.1106 0.1106
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.008 0.1849 0.1849
Trypanosoma cruzi casein kinase, putative 0.0074 0.1684 0.2283
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0152 0.0179
Echinococcus multilocularis phosphoglycerate kinase 1 0.0164 0.4032 0.4032
Loa Loa (eye worm) hypothetical protein 0.0052 0.1132 0.1449
Schistosoma mansoni hypothetical protein 0.0039 0.0793 0.0793
Trypanosoma brucei phosphoglycerate kinase, putative 0.006 0.1341 0.1814
Echinococcus multilocularis casein kinase I alpha 0.0074 0.1684 0.1684
Onchocerca volvulus 0.004 0.0826 0.1407
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0206 0.0206
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.008 0.1849 0.1849
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0065 0.0055
Echinococcus multilocularis Spectrin alpha actinin 0.0034 0.0661 0.0661
Treponema pallidum phosphoglycerate kinase 0.0164 0.4032 0.5678
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.2496 0.3393
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0514 0.1274
Echinococcus granulosus dna polymerase kappa 0.0077 0.177 0.177
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0015 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.2496 0.35
Brugia malayi phosphofructokinase 0.0105 0.2496 0.3194
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.7083 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.7083 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0227 0.0286
Echinococcus multilocularis casein kinase I alpha 0.0074 0.1684 0.1684
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.3351 0.4563
Echinococcus granulosus Chromo domain 0.0011 0.0065 0.0065
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0062 0.0062
Schistosoma mansoni glutaminase 0.0264 0.661 0.661
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0191 0.0241
Schistosoma mansoni hypothetical protein 0.0047 0.0985 0.0985
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.008 0.1849 0.1849
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.0828 0.2053
Brugia malayi chromobox protein homolog 3 0.0038 0.0756 0.0967
Brugia malayi ImpB/MucB/SamB family protein 0.0076 0.1742 0.223
Plasmodium falciparum phd finger protein, putative 0.0028 0.0508 0.1261
Loa Loa (eye worm) hypothetical protein 0.0052 0.1132 0.1449
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0497 0.0637
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0206 0.0206
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.3461 0.3461
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0019
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0384 0.0384
Brugia malayi casein kinase 1, delta 0.0074 0.1684 0.2155
Echinococcus granulosus zinc finger protein 0.0024 0.0399 0.0399
Schistosoma mansoni hypothetical protein 0.0395 1 1
Trichomonas vaginalis hypothetical protein 0.0011 0.0065 0.0055
Entamoeba histolytica hypothetical protein 0.0011 0.0065 0.0055
Echinococcus granulosus replication factor c subunit 1 0.001 0.0026 0.0026
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0514 0.0725
Brugia malayi Phosphoglycerate kinase 0.0164 0.4032 0.516
Loa Loa (eye worm) hypothetical protein 0.0043 0.0887 0.1134
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0065 0.0161
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.7326 1
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.006 0.1341 0.1814
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0175 0.0218
Echinococcus multilocularis nibrin 0.001 0.0026 0.0026
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0026 0.0033
Onchocerca volvulus 0.0229 0.5714 1
Trypanosoma brucei unspecified product 0.0035 0.0694 0.0929
Trypanosoma cruzi phosphoglycerate kinase, putative 0.006 0.1341 0.1814
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0065 0.0083
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0223 0.0552
Trypanosoma brucei DNA polymerase IV, putative 0.0077 0.177 0.2401
Leishmania major DNA polymerase kappa, putative 0.0016 0.0191 0.0241
Trypanosoma brucei unspecified product 0.0071 0.1606 0.2175
Loa Loa (eye worm) hypothetical protein 0.0042 0.0856 0.1095
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0052 0.1132 0.1449
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0508 0.1261
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0062 0.0116
Brugia malayi Temporarily assigned gene name protein 44 0.0026 0.046 0.0588
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0018 0.0004
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0514 0.1274
Brugia malayi PHD-finger family protein 0.0029 0.0532 0.0681
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0859 0.1155
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0828 0.1112
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0514 0.1274
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0175 0.0175
Entamoeba histolytica hypothetical protein 0.0011 0.0065 0.0055
Brugia malayi AF-10 protein 0.0009 0.0018 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0152 0.0179
Echinococcus multilocularis chromobox protein 2 0.0011 0.0065 0.0065
Schistosoma mansoni chromobox protein 0.0011 0.0065 0.0065
Echinococcus granulosus chromobox protein 2 0.0011 0.0065 0.0065
Schistosoma mansoni chromobox protein 0.0067 0.1521 0.1521
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0153 0.0153
Leishmania major DNA polymerase kappa, putative 0.0058 0.1271 0.1718
Loa Loa (eye worm) hypothetical protein 0.0013 0.0107 0.0136
Brugia malayi Bromodomain containing protein 0.004 0.0826 0.1056
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0471 0.063
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0033
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0514 0.1274
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0065 0.0055
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.014 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0065 0.0055
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0164 0.4032 1
Echinococcus granulosus protein quaking 0.0026 0.046 0.046
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.2496 0.3393
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.2496 0.35
Schistosoma mansoni hypothetical protein 0.008 0.1849 0.1849
Trichomonas vaginalis DNA polymerase eta, putative 0.0077 0.177 0.2472
Trypanosoma brucei chrX additional, unordered contigs 0.0016 0.0191 0.0241
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.006 0.1341 0.1814
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0026 0.0015
Leishmania major DNA damage repair protein, putative 0.0016 0.0191 0.0241
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0384 0.0384
Brugia malayi hypothetical protein 0.0228 0.5688 0.7279
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0065 0.0055
Mycobacterium ulcerans phosphoglycerate kinase 0.0164 0.4032 0.6085
Brugia malayi VAB-10A protein 0.0034 0.0661 0.0846
Loa Loa (eye worm) hypothetical protein 0.0023 0.0372 0.0476
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0019
Brugia malayi jmjC domain containing protein 0.0009 0.0015 0.0019
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0372 0.0489
Echinococcus multilocularis jumonji domain containing 1A 0.0009 0.0015 0.0015
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0793 0.1014
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0153 0.0153
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0514 0.1274
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0058 0.1271 0.2841
Trypanosoma cruzi casein kinase, putative 0.0074 0.1684 0.2283
Echinococcus multilocularis inhibitor of apoptosis protein 0.0052 0.1132 0.1132
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.7083 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0985 0.126
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0841 0.113
Loa Loa (eye worm) acetyltransferase 0.0142 0.3461 0.4428
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0026 0.0015
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0206 0.0206
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0372 0.0491
Schistosoma mansoni phosphatidylserine receptor 0.0009 0.0015 0.0015
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0164 0.4032 0.5678
Schistosoma mansoni hypothetical protein 0.0028 0.0508 0.0508
Echinococcus multilocularis dnaJ subfamily B 0.0395 1 1
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.008 0.1849 0.2366
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0065 0.0055
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.2496 0.6017
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0026 0.0064
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0793 0.1936
Loa Loa (eye worm) spectraplakin 0.0034 0.0661 0.0846
Brugia malayi Pre-SET motif family protein 0.0029 0.0541 0.0693
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0514 0.0691
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.7083 1
Brugia malayi jmjC domain containing protein 0.0092 0.2166 0.2771
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0904 0.0904
Giardia lamblia DNA damage repair protein 0.0016 0.0191 0.027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.7083 1
Schistosoma mansoni zinc finger protein 0.0015 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0017 0.0223 0.0285
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0968 0.0968
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0164 0.4032 0.5495

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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