Detailed information for compound 112247

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 462.793 | Formula: C34H54
  • H donors: 0 H acceptors: 0 LogP: 12.67 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C(=C\CC/C=C(/CC/C=C(/CC/C=C(/C1CC1)\C)\C)\C)/CC/C=C(/CC/C=C(\C1CC1)/C)\C
  • InChi: 1S/C34H54/c1-27(15-9-17-29(3)19-11-21-31(5)33-23-24-33)13-7-8-14-28(2)16-10-18-30(4)20-12-22-32(6)34-25-26-34/h13-14,17-18,21-22,33-34H,7-12,15-16,19-20,23-26H2,1-6H3/b27-13+,28-14+,29-17+,30-18+,31-21-,32-22+
  • InChiKey: RSWDDLHTQBXPBD-SIUKWMAASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament protein 0.003 0.03 0.0312
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0579 0.0606
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.001 0.004 0.0032
Schistosoma mansoni transcriptional factor nfil3/e4bp4 0.001 0.004 0.004
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0012 0.007 0.0065
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0068 0.00000000022213
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.0416 0.1129
Brugia malayi MH2 domain containing protein 0.0112 0.1387 0.1452
Schistosoma mansoni nuclear receptor 0.0012 0.007 0.007
Brugia malayi Matrixin family protein 0.0017 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0727 0.9507 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0253 0.0262
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0007 0.0004 0.001
Schistosoma mansoni nuclear hormone receptor 0.0012 0.007 0.007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0253 0.0258
Schistosoma mansoni par domain protein 0.001 0.004 0.004
Toxoplasma gondii aldehyde dehydrogenase 0.0044 0.0486 0.136
Echinococcus granulosus lysine specific demethylase 5A 0.0046 0.0508 0.05
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.021 0.2678 0.2678
Loa Loa (eye worm) hypothetical protein 0.0029 0.0293 0.0304
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0014 0.0096 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0056
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0096 0.0259
Schistosoma mansoni lozenge 0.0052 0.0596 0.0596
Echinococcus multilocularis snurportin 1 0.0236 0.3021 0.3016
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0118 0.0115
Onchocerca volvulus 0.0012 0.007 0.0056
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0868 0.0861
Echinococcus granulosus tar DNA binding protein 0.0091 0.1114 0.1107
Echinococcus granulosus bloom syndrome protein 0.0014 0.0096 0.0088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0868 0.0861
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0225 0.0225
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0508 0.0508
Brugia malayi hypothetical protein 0.0261 0.335 0.3518
Brugia malayi Calcitonin receptor-like protein seb-1 0.024 0.3069 0.3222
Entamoeba histolytica hypothetical protein 0.0085 0.1025 0.287
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0039
Schistosoma mansoni hypothetical protein 0.0236 0.3021 0.3021
Brugia malayi intermediate filament protein 0.003 0.03 0.0307
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0039
Trypanosoma cruzi cdc2-related kinase 1 0.0278 0.3573 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0474 0.0467
Schistosoma mansoni microtubule-associated protein tau 0.0761 0.9954 0.9954
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0416 0.0994
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Echinococcus multilocularis inositol monophosphatase 1 0.0035 0.0365 0.0357
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0278 0.3573 0.3755
Echinococcus granulosus intermediate filament protein 0.003 0.03 0.0292
Trichomonas vaginalis CMGC family protein kinase 0.0278 0.3573 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0132 0.0135
Entamoeba histolytica hypothetical protein 0.001 0.004 0.0113
Echinococcus granulosus histone acetyltransferase KAT2B 0.0128 0.16 0.1593
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0253 0.0253
Brugia malayi Matrixin family protein 0.0041 0.0451 0.0466
Brugia malayi nuclear hormone receptor 0.0026 0.0253 0.0258
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0096 0.0093
Loa Loa (eye worm) nuclear hormone receptor 0.0012 0.007 0.007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0014 0.0087 0.0232
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0096 0.0229
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.1304 0.3649
Echinococcus granulosus GTP binding nuclear protein Ran 0.0016 0.0122 0.0114
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.007 0.0062
Loa Loa (eye worm) RecQ helicase 0.0014 0.0096 0.0097
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0096 0.0093
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0138 0.0141
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0474 0.0467
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0091 0.1114 0.1169
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0014 0.0096 0.0088
Loa Loa (eye worm) hypothetical protein 0.0022 0.0199 0.0206
Onchocerca volvulus 0.0416 0.5398 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0253 0.0253
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.0122 0.0332
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.021 0.2678 0.2811
Brugia malayi hypothetical protein 0.0014 0.009 0.0086
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0057 0.0056
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0619 0.0643
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0014 0.0096 0.0097
Schistosoma mansoni transcription factor btf3 0.0039 0.0416 0.0416
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0868 0.091
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.0087 0.0053
Loa Loa (eye worm) Smad1 0.0008 0.0008 0.0005
Plasmodium falciparum histone acetyltransferase GCN5 0.0036 0.0377 0.091
Leishmania major hypothetical protein, conserved 0.0011 0.0057 0.0118
Mycobacterium ulcerans aldehyde dehydrogenase 0.0044 0.0486 0.7801
Brugia malayi RNA binding protein 0.0091 0.1114 0.1164
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0868 0.2431
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0365 0.0985
Echinococcus multilocularis ccaat enhancer binding protein delta ccaat enhancer binding protein beta 0.001 0.004 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0132 0.0135
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0042 0.0468 0.046
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0012 0.007 0.007
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0011 0.0057 0.0159
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0278 0.3573 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.061 0.0633
Echinococcus multilocularis lysine specific demethylase 5A 0.0042 0.0468 0.046
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0011 0.0057 0.0149
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0018 0.0144 0.0217
Brugia malayi jmjC domain containing protein 0.0046 0.0508 0.0526
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0076 0.0908 0.09
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0868 0.2423
Brugia malayi nuclear hormone receptor family member nhr-6 0.0012 0.007 0.0065
Schistosoma mansoni coup transcription factor 0.0026 0.0253 0.0253
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0868 0.2399
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0097 0.0089
Echinococcus multilocularis cyclin dependent kinase 0.0278 0.3573 0.3567
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0253 0.0245
Brugia malayi acetyltransferase, GNAT family protein 0.0132 0.1649 0.1727
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0012 0.007 0.0062
Echinococcus multilocularis 0.0008 0.0015 0.0007
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0097 0.0089
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0008 0.0008
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0365 0.0848
Brugia malayi Cell death specification protein 2 0.001 0.004 0.0034
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0044 0.0486 0.1324
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.001 0.004 0.0032
Brugia malayi nuclear receptor NHR-88 0.0026 0.0253 0.0258
Echinococcus multilocularis lamin dm0 0.003 0.03 0.0292
Loa Loa (eye worm) TAR-binding protein 0.0091 0.1114 0.1169
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0011 0.0057 0.0057
Loa Loa (eye worm) DR-78 0.0012 0.007 0.007
Treponema pallidum exodeoxyribonuclease (exoA) 0.0014 0.0087 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0253 0.0245
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0474 0.0467
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0253 0.0245
Schistosoma mansoni hypothetical protein 0.001 0.004 0.004
Plasmodium falciparum basic transcription factor 3b, putative 0.0039 0.0416 0.1023
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0416 0.0994
Loa Loa (eye worm) MH2 domain-containing protein 0.0112 0.1387 0.1456
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0579 0.1459
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0014 0.0087 0.0202
Echinococcus multilocularis cyclin dependent kinase 5 0.0278 0.3573 0.3567
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0253 0.0258
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0095 0.0086
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.005 0.0571 0.0597
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0062 0.0725 0.0717
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0014 0.0087 0.0131
Brugia malayi ubiquitin conjugating enzyme protein 13 0.021 0.2678 0.2811
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0039 0.042 0.1174
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0011 0.0057 0.0118
Loa Loa (eye worm) matrix metalloproteinase 0.0017 0.0132 0.0135
Toxoplasma gondii NAC domain-containing protein 0.0039 0.0416 0.1166
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0095 0.0086
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.009 0.009
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.009 0.0091
Brugia malayi nuclear hormone receptor family member odr-7 0.0012 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0579 0.0571
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0096 0.0081
Brugia malayi cell division control protein 2 homolog 0.0278 0.3573 0.3752
Echinococcus multilocularis bloom syndrome protein 0.0014 0.0096 0.0088
Echinococcus granulosus histone lysine methyltransferase setb 0.0024 0.0225 0.0217
Plasmodium vivax SET domain protein, putative 0.0024 0.0225 0.063
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0017 0.0132 0.0132
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0579 0.1586
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0579 0.1613
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0011 0.0057 0.0159
Loa Loa (eye worm) cytochrome P450 0.0008 0.0015 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0253 0.0262
Toxoplasma gondii HEAT repeat-containing protein 0.0022 0.0199 0.0557
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0021 0.0181 0.0182
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0008 0.0005
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0095 0.0086
Mycobacterium ulcerans aldehyde dehydrogenase 0.0044 0.0486 0.7801
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0098
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0579 0.0571
Schistosoma mansoni tar DNA-binding protein 0.0091 0.1114 0.1114
Schistosoma mansoni nuclear receptor 0.0012 0.007 0.007
Schistosoma mansoni smad1 5 8 and 0.0008 0.0008 0.0008
Onchocerca volvulus Matrix metalloproteinase homolog 0.0038 0.0406 0.0683
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0068 0.00000000022213
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0091
Brugia malayi steroid hormone receptor 0.0026 0.0253 0.0258
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.335 0.3345
Loa Loa (eye worm) hypothetical protein 0.0021 0.0181 0.0187
Onchocerca volvulus 0.0017 0.0132 0.0172
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0161 0.2028 0.213
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0253 0.0245
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0097 0.0089
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0253 0.0253
Echinococcus multilocularis transcription factor btf3 0.0039 0.0416 0.0409
Onchocerca volvulus 0.0026 0.0253 0.0397
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0076 0.0908 0.09
Trypanosoma brucei cdc2-related kinase 1 0.0278 0.3573 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0068 0.00000000022213
Schistosoma mansoni tar DNA-binding protein 0.0091 0.1114 0.1114
Entamoeba histolytica transcription factor BTF3, putative 0.0039 0.0416 0.1166
Brugia malayi hypothetical protein 0.0085 0.1025 0.1071
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0008 0.0015 0.0031
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.021 0.2678 0.7496
Loa Loa (eye worm) CYP4Cod1 0.0008 0.0015 0.0012
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0031 0.0317 0.501
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0014 0.0096 0.0088
Loa Loa (eye worm) hypothetical protein 0.0261 0.335 0.3521
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0278 0.3573 1
Leishmania major importin beta-1 subunit, putative 0.0018 0.0144 0.0363
Schistosoma mansoni hypothetical protein 0.0076 0.0908 0.0908
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0253 0.0253
Onchocerca volvulus 0.0053 0.061 0.1063
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0044 0.0486 0.7801
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0016 0.0122 0.0232
Trichomonas vaginalis bromodomain-containing protein, putative 0.0039 0.042 0.1003
Loa Loa (eye worm) jmjC domain-containing protein 0.0046 0.0508 0.0531
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0095 0.0086
Schistosoma mansoni DNA helicase recq5 0.0014 0.0096 0.0096
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0253 0.0253
Onchocerca volvulus Matrilysin homolog 0.0038 0.0406 0.0683
Schistosoma mansoni ran 0.0016 0.0122 0.0122
Plasmodium vivax JmjC domain containing protein 0.0011 0.0057 0.0159
Trypanosoma cruzi importin beta-1 subunit, putative 0.0018 0.0144 0.0393
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0014 0.0087 0.0202
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0035 0.0365 0.5805
Schistosoma mansoni ran 0.0016 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0024 0.0226 0.0226
Brugia malayi jmjC domain containing protein 0.0011 0.0057 0.0051
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0253 0.0245
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0097 0.0089
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0253 0.0245
Schistosoma mansoni jumonji domain containing protein 0.0011 0.0057 0.0057
Trypanosoma cruzi cytochrome P450, putative 0.0008 0.0015 0.0031
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0253 0.0253
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0474 0.0474
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.0122 0.0332
Leishmania major basic transcription factor 3a, putative 0.0039 0.0416 0.1129
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0508 0.0508
Echinococcus granulosus jumonji domain containing 1A 0.0011 0.0057 0.0049
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0253 0.0245
Echinococcus multilocularis lysine specific demethylase 6a 0.0011 0.0057 0.0049
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0035 0.0365 0.1023
Schistosoma mansoni hypothetical protein 0.0076 0.0908 0.0908
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0138 0.013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0253 0.0258
Trypanosoma brucei protein kinase, putative 0.0051 0.0579 0.1586
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0068 0.00000000022213
Trypanosoma cruzi cdc2-related kinase 3 0.0278 0.3573 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0016 0.0122 0.0342
Trichomonas vaginalis DNA helicase recq1, putative 0.0014 0.0096 0.0081
Loa Loa (eye worm) runx1 0.0052 0.0596 0.0624
Schistosoma mansoni survival motor neuron protein 0.0053 0.061 0.061
Echinococcus granulosus protocadherin 11 0.001 0.004 0.0032
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0014 0.0087 0.0078
Schistosoma mansoni zinc finger protein 0.0012 0.007 0.007
Onchocerca volvulus 0.003 0.03 0.0485
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0054 0.0619 0.1697
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0579 0.0579
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0056
Brugia malayi Protein kinase domain containing protein 0.0278 0.3573 0.3752
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0044 0.0486 0.0478
Schistosoma mansoni tar DNA-binding protein 0.0091 0.1114 0.1114
Echinococcus multilocularis GPCR, family 2 0.0076 0.0908 0.09
Brugia malayi Cytochrome P450 family protein 0.0008 0.0015 0.0007
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0135 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0253 0.0258
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0016 0.0122 0.0342
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0016 0.0122 0.0114
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.001 0.004 0.0032
Brugia malayi TAR-binding protein 0.0091 0.1114 0.1164
Mycobacterium leprae PROBABLE HYDROLASE 0.0021 0.0181 0.5503
Echinococcus multilocularis protocadherin 11 0.001 0.004 0.0032
Plasmodium vivax importin-beta 2, putative 0.0022 0.0199 0.0557
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0021 0.0181 0.2757
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0253 0.0258
Brugia malayi hypothetical protein 0.001 0.004 0.0034
Entamoeba histolytica recQ family DNA helicase 0.0007 0.0004 0.001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0253 0.0245
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0096 0.0269
Schistosoma mansoni hypothetical protein 0.001 0.004 0.004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.03 0.0312
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0054 0.0619 0.0611
Echinococcus granulosus thyroid hormone receptor alpha 0.0012 0.007 0.0062
Brugia malayi jmjC domain containing protein 0.0011 0.0057 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0253 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0416 0.0994
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0225 0.0217
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0253 0.0245
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0016 0.0122 0.0186
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.007 0.0062
Onchocerca volvulus 0.0012 0.007 0.0056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0132 0.0135
Brugia malayi nuclear receptor RXR 0.0014 0.009 0.0086
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0564 0.7346 0.7344
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0057 0.0056
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0253 0.0258
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0868 0.0906
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0253 0.0258
Entamoeba histolytica cell division protein kinase 2, putative 0.0278 0.3573 1
Brugia malayi ecdysteroid receptor 0.0026 0.0253 0.0258
Schistosoma mansoni thyrotroph embryonic factor related 0.001 0.004 0.004
Echinococcus granulosus nuclear receptor nhr 48 0.0012 0.007 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0619 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0579 0.1586
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0365 0.0848
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.002 0.002
Trypanosoma brucei importin beta-1 subunit, putative 0.0022 0.0199 0.0518
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0253 0.0245
Brugia malayi nuclear receptor NHR-88 0.0012 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Schistosoma mansoni tar DNA-binding protein 0.0091 0.1114 0.1114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0474 0.0474
Echinococcus granulosus ccaat enhancer binding protein delta 0.001 0.004 0.0032
Toxoplasma gondii exonuclease III APE 0.0014 0.0087 0.0242
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0474 0.0474
Brugia malayi RNA, U transporter 1 0.0063 0.0737 0.0767
Schistosoma mansoni phosphatidylserine receptor 0.0011 0.0057 0.0057
Brugia malayi Cytochrome P450 family protein 0.0037 0.0401 0.0413
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0015 0.0012
Trypanosoma cruzi cdc2-related kinase 3 0.0278 0.3573 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0011 0.0057 0.0049
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0096 0.0269
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.021 0.2678 0.2672
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0868 0.2423
Brugia malayi hypothetical protein 0.0014 0.009 0.0086
Schistosoma mansoni nuclear receptor nhr-48 0.0012 0.007 0.007
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0031 0.0317 1
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0416 0.1157
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0278 0.3573 0.3567
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0401 0.0418
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0054 0.0619 0.0611
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.009 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0039
Onchocerca volvulus 0.0183 0.2319 0.4253
Schistosoma mansoni cpg binding protein 0.0054 0.0616 0.0616
Brugia malayi jmjC domain containing protein 0.0011 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0091
Brugia malayi jmjC domain containing protein 0.0042 0.0468 0.0484
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.021 0.2678 0.7448
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0253 0.0258
Brugia malayi Cytochrome P450 family protein 0.0008 0.0015 0.0007
Echinococcus granulosus protocadherin 11 0.001 0.004 0.0032
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0365 0.0985
Loa Loa (eye worm) inositol-1 0.0035 0.0365 0.0381
Schistosoma mansoni smad1 5 8 and 0.0008 0.0008 0.0008
Brugia malayi exodeoxyribonuclease III family protein 0.0014 0.0087 0.0082
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0018 0.0144 0.0217
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.009 0.0086
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0253 0.0253
Trichomonas vaginalis CMGC family protein kinase 0.0278 0.3573 1
Schistosoma mansoni cpg binding protein 0.0057 0.0656 0.0656
Echinococcus multilocularis nuclear receptor nhr 48 0.0012 0.007 0.0062
Brugia malayi CXXC zinc finger family protein 0.0054 0.0616 0.064
Echinococcus granulosus inositol monophosphatase 1 0.0035 0.0365 0.0357
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.335 0.3345
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0253 0.0258
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0579 0.0571
Loa Loa (eye worm) matrixin family protein 0.0041 0.0451 0.0471
Loa Loa (eye worm) hypothetical protein 0.0416 0.5398 0.5676
Echinococcus granulosus histone acetyltransferase KAT2B 0.0039 0.042 0.0412
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0016 0.0122 0.0302
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0253 0.0245
Brugia malayi conserved hypotetical protein 0.0012 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.000000000081912
Brugia malayi Matrixin family protein 0.0017 0.0132 0.0131
Schistosoma mansoni Smad4 0.0008 0.0008 0.0008
Brugia malayi cytochrome P450 0.0008 0.0015 0.0007
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0008 0.0015 0.0031
Loa Loa (eye worm) hypothetical protein 0.0024 0.0225 0.0233
Entamoeba histolytica cell division protein kinase 2, putative 0.0278 0.3573 1
Schistosoma mansoni hypothetical protein 0.0765 1 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.021 0.2678 0.7494
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.001 0.004 0.0032
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0016 0.0122 0.0125
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0014 0.0096 0.0112
Echinococcus multilocularis musashi 0.003 0.03 0.0292
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0035 0.0365 1
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0253 0.0253
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0225 0.063
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0253 0.0258
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0253 0.0245
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.001 0.004 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Loa Loa (eye worm) RNA binding protein 0.0091 0.1114 0.1169
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0076 0.0908 0.0947
Giardia lamblia Kinase, CMGC CDK 0.0278 0.3573 1
Schistosoma mansoni inositol monophosphatase 0.0035 0.0365 0.0365
Schistosoma mansoni hypothetical protein 0.0318 0.4102 0.4102
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0091
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0365 0.1013
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0014 0.0087 0.0242
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0085 0.1025 0.1018
Echinococcus granulosus cyclin dependent kinase 1 0.0278 0.3573 0.3567
Loa Loa (eye worm) hypothetical protein 0.003 0.03 0.0312
Echinococcus granulosus lamin dm0 0.003 0.03 0.0292
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0022 0.0198 0.019
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0253 0.0253
Trypanosoma cruzi cytochrome P450, putative 0.0008 0.0015 0.0031
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0253 0.0245
Schistosoma mansoni phd/f-box containing protein 0.0011 0.0057 0.0057
Trypanosoma brucei importin beta-1 subunit, putative 0.0022 0.0199 0.0518
Brugia malayi Hemopexin family protein 0.0024 0.0226 0.0229
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.007 0.0062
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.004 0.0441 0.0441
Brugia malayi hypothetical protein 0.0012 0.007 0.0065
Schistosoma mansoni lamin 0.003 0.03 0.03
Mycobacterium ulcerans aldehyde dehydrogenase 0.0044 0.0486 0.7801
Echinococcus multilocularis jumonji domain containing 1A 0.0011 0.0057 0.0049
Brugia malayi tailless protein 0.0012 0.007 0.0065
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0008 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0068 0.00000000022213
Loa Loa (eye worm) nuclear receptor NHR-67 0.0012 0.007 0.007
Brugia malayi hypothetical protein 0.0012 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.021 0.2678 0.7456
Mycobacterium ulcerans hydrolase 0.0021 0.0181 0.2757
Brugia malayi jmjC domain containing protein 0.0011 0.0057 0.0051
Schistosoma mansoni protein phosphatase 2C 0.0011 0.0057 0.0057
Brugia malayi Nuclear hormone receptor E75 0.0012 0.007 0.0065
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0024 0.0225 0.0217
Echinococcus multilocularis importin subunit beta 1 0.0022 0.0199 0.0191
Brugia malayi hypothetical protein 0.001 0.004 0.0034
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0278 0.3573 0.3755
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0118 0.012
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0253 0.0253
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0068 0.00000000022213
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0278 0.3573 1
Brugia malayi Hepatic leukemia factor 0.001 0.004 0.0034
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0464 0.0456
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0095 0.0095
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0096 0.0081
Schistosoma mansoni hypothetical protein 0.0076 0.0908 0.0908
Loa Loa (eye worm) acetyltransferase 0.0132 0.1649 0.1731
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0085 0.1025 0.1018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0115 0.1422 0.1422
Plasmodium falciparum importin beta, putative 0.0022 0.0199 0.0405
Echinococcus multilocularis cpg binding protein 0.0057 0.0656 0.0649
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0225 0.0225
Entamoeba histolytica hypothetical protein 0.0039 0.0416 0.1166
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0253 0.0245
Echinococcus multilocularis lamin 0.003 0.03 0.0292
Schistosoma mansoni hypothetical protein 0.0085 0.1025 0.1025
Giardia lamblia Histone acetyltransferase GCN5 0.0036 0.0377 0.0953
Echinococcus granulosus JmjC domain containing protein 4 0.0011 0.0057 0.0049
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.0087 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.3573 0.3573
Giardia lamblia Kinase, CMGC CDK 0.0278 0.3573 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0253 0.0262
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0012 0.007 0.007
Brugia malayi hypothetical protein 0.001 0.004 0.0034
Trichomonas vaginalis importin beta-1, putative 0.0018 0.0144 0.0217
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Echinococcus multilocularis dnaJ subfamily B 0.0765 1 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.021 0.2678 0.7494
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0014 0.0096 0.0112
Brugia malayi MAP kinase sur-1 0.0051 0.0579 0.0601
Brugia malayi Matrixin family protein 0.0017 0.0132 0.0131
Brugia malayi Cytochrome P450 family protein 0.0008 0.0015 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.3573 0.3573
Brugia malayi bZIP transcription factor family protein 0.001 0.004 0.0034
Echinococcus multilocularis protocadherin 11 0.001 0.004 0.0032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0585 0.7632 0.763
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0042 0.0468 0.046
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0035 0.0365 0.1023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0068 0.00000000022213
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.03 0.0307
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0416 0.1157
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.009 0.0082
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0044 0.0486 0.0478
Brugia malayi Bloom's syndrome protein homolog 0.0014 0.0096 0.0093
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0868 0.2399
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0068 0.00000000022213
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0464 0.0456
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Loa Loa (eye worm) CXXC zinc finger family protein 0.0054 0.0616 0.0644
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.021 0.2678 0.7496
Loa Loa (eye worm) matrixin family protein 0.0038 0.0406 0.0424
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0043 0.0474 0.0491
Plasmodium falciparum protein kinase 5 0.0278 0.3573 1
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.021 0.2678 0.2814
Entamoeba histolytica hypothetical protein 0.0085 0.1025 0.287
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.007 0.0056
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0579 0.1613
Echinococcus multilocularis Protein lozenge 0.0052 0.0596 0.0588
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0039 0.042 0.1174
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0091 0.1114 0.1114
Trypanosoma brucei cdc2-related kinase 3 0.0278 0.3573 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0868 0.0868
Brugia malayi Importin beta-1 subunit 0.0022 0.0199 0.0201
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0253 0.0245
Loa Loa (eye worm) hypothetical protein 0.0076 0.0908 0.0951
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Echinococcus granulosus transcription factor btf3 0.0039 0.0416 0.0409
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0278 0.3573 0.3755
Schistosoma mansoni jumonji domain containing protein 0.0042 0.0468 0.0468
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0253 0.0245
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0579 0.1613
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0014 0.0087 0.0078
Echinococcus granulosus lamin 0.003 0.03 0.0292
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.021 0.2678 0.2814
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0057 0.0056
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0579 0.1459
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0014 0.0087 0.1188
Loa Loa (eye worm) transcription factor SMAD2 0.0112 0.1387 0.1456
Schistosoma mansoni smad1 5 8 and 0.0008 0.0008 0.0008
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0564 0.7346 0.7344
Echinococcus multilocularis X box binding protein 1 0.0318 0.4102 0.4097
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0132 0.1649 0.1649
Schistosoma mansoni blooms syndrome DNA helicase 0.0007 0.0004 0.0004
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0054 0.0619 1
Brugia malayi Pre-SET motif family protein 0.0161 0.2028 0.2127
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.0087 0.0242
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0579 0.1459
Brugia malayi Latrophilin receptor protein 2 0.0076 0.0908 0.0947
Entamoeba histolytica acetyltransferase, GNAT family 0.0036 0.0377 0.1055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0253 0.0262
Schistosoma mansoni hypothetical protein 0.0076 0.0908 0.0908
Schistosoma mansoni aldehyde dehydrogenase 0.0044 0.0486 0.0486
Brugia malayi Pre-SET motif family protein 0.0024 0.0225 0.0228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Plasmodium vivax protein kinase Crk2 0.0278 0.3573 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.2069 0.2173
Schistosoma mansoni hypothetical protein 0.0164 0.2069 0.2069
Trypanosoma cruzi cdc2-related kinase 1 0.0278 0.3573 1
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.021 0.2678 0.2672
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0253 0.0397
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0253 0.0262
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.021 0.2678 0.7448
Brugia malayi hypothetical protein 0.0416 0.5398 0.5674
Echinococcus multilocularis thyroid hormone receptor alpha 0.0026 0.0253 0.0245
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0365 0.1013
Brugia malayi RNA recognition motif domain containing protein 0.0091 0.1114 0.1164
Echinococcus granulosus lysine specific demethylase 6a 0.0011 0.0057 0.0049
Brugia malayi Inositol-1 0.0035 0.0365 0.0376
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0039
Brugia malayi latrophilin 2 splice variant baaae 0.0164 0.2069 0.2169
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0579 0.1621
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0253 0.0258
Schistosoma mansoni transcription factor LCR-F1 0.0085 0.1025 0.1025
Echinococcus granulosus GPCR family 2 0.0076 0.0908 0.09
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0253 0.0397
Echinococcus granulosus transcriptional factor nfil3:e4bp4 0.001 0.004 0.0032
Brugia malayi Nuclear hormone receptor E75 0.0012 0.007 0.0065
Brugia malayi beta-NAC-like protein 0.0039 0.0416 0.043
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0039 0.042 0.1174
Echinococcus granulosus cytochrome P450 2K1 0.0008 0.0015 0.0007
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0579 0.1613
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.007 0.0062
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0619 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0253 0.0262
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0579 0.1586
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0008 0.0015 0.0031
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0062 0.0725 0.0717
Loa Loa (eye worm) hypothetical protein 0.0416 0.5398 0.5676
Giardia lamblia Sgs1 DNA helicase, putative 0.0014 0.0096 0.0158
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0012 0.007 0.0062
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0014 0.0087 0.1188
Brugia malayi nuclear receptor NHR-67 0.0012 0.007 0.0065
Trichomonas vaginalis set domain proteins, putative 0.0183 0.2319 0.6424
Schistosoma mansoni ap endonuclease 0.0014 0.0087 0.0087
Echinococcus multilocularis microtubule associated protein 2 0.0761 0.9954 0.9954
Schistosoma mansoni inositol monophosphatase 0.0035 0.0365 0.0365
Onchocerca volvulus 0.0024 0.0226 0.0347
Echinococcus multilocularis phd:f box containing protein 0.0011 0.0057 0.0049
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0091
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0039 0.042 0.1003
Entamoeba histolytica hypothetical protein 0.0018 0.0144 0.0403
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0015 0.0012
Brugia malayi ecdysone receptor 0.0012 0.007 0.0065
Schistosoma mansoni nuclear hormone receptor 0.0012 0.007 0.007
Schistosoma mansoni importin beta-1 0.0022 0.0199 0.0199
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0579 0.0571
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0225 0.0225
Brugia malayi Matrixin family protein 0.0017 0.0132 0.0131
Schistosoma mansoni hypothetical protein 0.0008 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0253 0.0258
Brugia malayi orphan nuclear receptor NR2E1 0.0012 0.007 0.0065
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0054 0.0619 0.0619
Loa Loa (eye worm) pigment dispersing factor receptor c 0.024 0.3069 0.3225
Echinococcus granulosus cpg binding protein 0.0057 0.0656 0.0649
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.021 0.2678 0.7496
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0091
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0579 0.1459
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0012 0.007 0.0062
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Echinococcus granulosus snurportin 1 0.0236 0.3021 0.3016
Entamoeba histolytica hypothetical protein 0.0085 0.1025 0.287
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0253 0.0258
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0253 0.0258
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0016 0.0122 0.012
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0011 0.0057 0.0149
Echinococcus multilocularis transcriptional factor nfil3:e4bp4 0.001 0.004 0.0032
Schistosoma mansoni smad 0.0008 0.0008 0.0008
Echinococcus granulosus cyclin dependent kinase 0.0278 0.3573 0.3567
Entamoeba histolytica Ran family GTPase 0.0016 0.0122 0.0342
Schistosoma mansoni ap endonuclease 0.0014 0.0087 0.0087
Schistosoma mansoni cytochrome P450 0.0008 0.0015 0.0015
Trichomonas vaginalis ran, putative 0.0016 0.0122 0.0154
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0727 0.9507 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.007 0.0062
Loa Loa (eye worm) ICD-1 protein 0.0039 0.0416 0.0434
Echinococcus granulosus microtubule associated protein 2 0.0761 0.9954 0.9954
Schistosoma mansoni DNA helicase recq1 0.0014 0.0096 0.0096
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0096 0.0269
Loa Loa (eye worm) latrophilin receptor protein 2 0.0076 0.0908 0.0951
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.007 0.0056
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.009 0.0082
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0253 0.0397
Echinococcus granulosus phd:f box containing protein 0.0011 0.0057 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0253 0.0258
Brugia malayi Cell death specification protein 2 0.001 0.004 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0253 0.0262
Loa Loa (eye worm) hypothetical protein 0.0014 0.0096 0.0097
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.021 0.2678 0.7486
Schistosoma mansoni intermediate filament proteins 0.003 0.03 0.03
Echinococcus multilocularis cyclin dependent kinase 1 0.0278 0.3573 0.3567
Entamoeba histolytica hypothetical protein 0.0085 0.1025 0.287
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0056
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0579 0.1526
Trichomonas vaginalis CMGC family protein kinase 0.0278 0.3573 1
Echinococcus granulosus importin subunit beta 1 0.0022 0.0199 0.0191
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0014 0.0096 0.0088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0236 0.3021 0.3175
Echinococcus multilocularis tar DNA binding protein 0.0091 0.1114 0.1107
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0253 0.0245
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.001 0.0033 0.0052
Onchocerca volvulus 0.0054 0.0616 0.1075
Brugia malayi Cell death specification protein 2 0.001 0.004 0.0034
Brugia malayi nuclear receptor RXR 0.0012 0.007 0.0065
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.009 0.009
Onchocerca volvulus Matrilysin homolog 0.0017 0.0132 0.0172
Trypanosoma brucei ubiquitin-protein ligase, putative 0.021 0.2678 0.7486
Echinococcus multilocularis cyclin dependent kinase 1 0.0278 0.3573 0.3567
Loa Loa (eye worm) bZIP transcription factor family protein 0.001 0.004 0.0039
Schistosoma mansoni lamin 0.003 0.03 0.03
Onchocerca volvulus 0.003 0.03 0.0485
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0014 0.0087 0.0232
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0043 0.0474 0.0495
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0012 0.007 0.007
Brugia malayi nuclear hormone receptor 0.0012 0.007 0.0065
Echinococcus granulosus X box binding protein 1 0.0318 0.4102 0.4097
Toxoplasma gondii cytochrome p450 superfamily protein 0.0008 0.0015 0.0042
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0014 0.0087 0.0087
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0138 0.013
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0132 0.1649 0.1642
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0474 0.0467
Schistosoma mansoni hypothetical protein 0.0053 0.061 0.061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0225 0.0225
Schistosoma mansoni aldehyde dehydrogenase 0.0044 0.0486 0.0486
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.0087 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0253 0.0258
Loa Loa (eye worm) cell death specification protein 2 0.001 0.004 0.0039
Schistosoma mansoni cpg binding protein 0.0057 0.0656 0.0656
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.0416 0.1166
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0039
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0096 0.0229
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.007 0.0062
Leishmania major GTP-binding protein, putative 0.0016 0.0122 0.0302
Trichomonas vaginalis inositol monophosphatase, putative 0.0035 0.0365 0.0848
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Echinococcus granulosus cyclin dependent kinase 5 0.0278 0.3573 0.3567
Loa Loa (eye worm) hypothetical protein 0.0272 0.3502 0.3681
Onchocerca volvulus 0.0024 0.0225 0.0345

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) uM Inhibitory activity against Oxidosqualene-lanosterol cyclase in pig liver; NI-No inhibitory effect at 400 microM ChEMBL. 2769687
IC50 (binding) uM Inhibitory activity against Squalene Epoxidase in pig liver; NI-No inhibitory effect at 400 microM ChEMBL. 2769687
IC50 (binding) NI 0 uM Inhibitory activity against Squalene Epoxidase in pig liver; NI-No inhibitory effect at 400 microM ChEMBL. 2769687
IC50 (binding) NI 0 uM Inhibitory activity against Oxidosqualene-lanosterol cyclase in pig liver; NI-No inhibitory effect at 400 microM ChEMBL. 2769687

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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