Detailed information for compound 112549

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 436.755 | Formula: C32H52
  • H donors: 0 H acceptors: 0 LogP: 12.12 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C(=C\CC/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)/CC/C=C(/CC/C=C(/C1CC1)\C)\C
  • InChi: 1S/C32H52/c1-26(2)14-10-17-29(5)20-11-18-27(3)15-8-9-16-28(4)19-12-21-30(6)22-13-23-31(7)32-24-25-32/h14-16,20-21,23,32H,8-13,17-19,22,24-25H2,1-7H3/b27-15+,28-16+,29-20+,30-21+,31-23+
  • InChiKey: HKWKUDAFIYUXJR-UGMXIYSVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor RXR 0.0014 0.009 0.0086
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0564 0.7346 0.7344
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0057 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0253 0.0258
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0253 0.0258
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0868 0.0906
Loa Loa (eye worm) hypothetical protein 0.0017 0.0132 0.0135
Onchocerca volvulus 0.0012 0.007 0.0056
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0016 0.0122 0.0186
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.007 0.0062
Brugia malayi jmjC domain containing protein 0.0011 0.0057 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0416 0.0994
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0253 0.0245
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0253 0.0262
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0225 0.0217
Echinococcus granulosus thyroid hormone receptor alpha 0.0012 0.007 0.0062
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0054 0.0619 0.0611
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.03 0.0312
Schistosoma mansoni hypothetical protein 0.001 0.004 0.004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0096 0.0269
Trypanosoma cruzi cdc2-related kinase 3 0.0278 0.3573 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0011 0.0057 0.0049
Brugia malayi Cytochrome P450 family protein 0.0037 0.0401 0.0413
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0015 0.0012
Toxoplasma gondii exonuclease III APE 0.0014 0.0087 0.0242
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0474 0.0474
Brugia malayi RNA, U transporter 1 0.0063 0.0737 0.0767
Schistosoma mansoni phosphatidylserine receptor 0.0011 0.0057 0.0057
Brugia malayi nuclear receptor NHR-88 0.0012 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Schistosoma mansoni tar DNA-binding protein 0.0091 0.1114 0.1114
Echinococcus granulosus ccaat enhancer binding protein delta 0.001 0.004 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0474 0.0474
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.002 0.002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0253 0.0245
Trypanosoma brucei importin beta-1 subunit, putative 0.0022 0.0199 0.0518
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0619 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0579 0.1586
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0365 0.0848
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Schistosoma mansoni thyrotroph embryonic factor related 0.001 0.004 0.004
Echinococcus granulosus nuclear receptor nhr 48 0.0012 0.007 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Entamoeba histolytica cell division protein kinase 2, putative 0.0278 0.3573 1
Brugia malayi ecdysteroid receptor 0.0026 0.0253 0.0258
Onchocerca volvulus 0.0183 0.2319 0.4253
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0039
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.009 0.0086
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0054 0.0619 0.0611
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0401 0.0418
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0278 0.3573 0.3567
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0031 0.0317 1
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0416 0.1157
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0868 0.2423
Brugia malayi hypothetical protein 0.0014 0.009 0.0086
Schistosoma mansoni nuclear receptor nhr-48 0.0012 0.007 0.007
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0096 0.0269
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.021 0.2678 0.2672
Brugia malayi CXXC zinc finger family protein 0.0054 0.0616 0.064
Echinococcus granulosus inositol monophosphatase 1 0.0035 0.0365 0.0357
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.335 0.3345
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.009 0.0086
Trichomonas vaginalis CMGC family protein kinase 0.0278 0.3573 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0253 0.0253
Echinococcus multilocularis nuclear receptor nhr 48 0.0012 0.007 0.0062
Schistosoma mansoni cpg binding protein 0.0057 0.0656 0.0656
Schistosoma mansoni smad1 5 8 and 0.0008 0.0008 0.0008
Brugia malayi exodeoxyribonuclease III family protein 0.0014 0.0087 0.0082
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0018 0.0144 0.0217
Loa Loa (eye worm) inositol-1 0.0035 0.0365 0.0381
Brugia malayi jmjC domain containing protein 0.0042 0.0468 0.0484
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.021 0.2678 0.7448
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0253 0.0258
Brugia malayi Cytochrome P450 family protein 0.0008 0.0015 0.0007
Echinococcus granulosus protocadherin 11 0.001 0.004 0.0032
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0365 0.0985
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0091
Schistosoma mansoni cpg binding protein 0.0054 0.0616 0.0616
Brugia malayi jmjC domain containing protein 0.0011 0.0057 0.0051
Loa Loa (eye worm) CYP4Cod1 0.0008 0.0015 0.0012
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0031 0.0317 0.501
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0014 0.0096 0.0088
Loa Loa (eye worm) hypothetical protein 0.0261 0.335 0.3521
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0278 0.3573 1
Schistosoma mansoni hypothetical protein 0.0076 0.0908 0.0908
Leishmania major importin beta-1 subunit, putative 0.0018 0.0144 0.0363
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.021 0.2678 0.7496
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0008 0.0015 0.0031
Trypanosoma brucei cdc2-related kinase 1 0.0278 0.3573 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0068 0.00000000022213
Schistosoma mansoni tar DNA-binding protein 0.0091 0.1114 0.1114
Entamoeba histolytica transcription factor BTF3, putative 0.0039 0.0416 0.1166
Brugia malayi hypothetical protein 0.0085 0.1025 0.1071
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0076 0.0908 0.09
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0097 0.0089
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0161 0.2028 0.213
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0253 0.0245
Echinococcus multilocularis transcription factor btf3 0.0039 0.0416 0.0409
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0253 0.0253
Onchocerca volvulus 0.0026 0.0253 0.0397
Onchocerca volvulus 0.0017 0.0132 0.0172
Loa Loa (eye worm) hypothetical protein 0.0021 0.0181 0.0187
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0091
Brugia malayi steroid hormone receptor 0.0026 0.0253 0.0258
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.335 0.3345
Onchocerca volvulus Matrix metalloproteinase homolog 0.0038 0.0406 0.0683
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0068 0.00000000022213
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0097 0.0089
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0253 0.0245
Schistosoma mansoni hypothetical protein 0.0024 0.0226 0.0226
Brugia malayi jmjC domain containing protein 0.0011 0.0057 0.0051
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0035 0.0365 0.5805
Schistosoma mansoni ran 0.0016 0.0122 0.0122
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0253 0.0253
Schistosoma mansoni DNA helicase recq5 0.0014 0.0096 0.0096
Onchocerca volvulus Matrilysin homolog 0.0038 0.0406 0.0683
Schistosoma mansoni ran 0.0016 0.0122 0.0122
Plasmodium vivax JmjC domain containing protein 0.0011 0.0057 0.0159
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0014 0.0087 0.0202
Trypanosoma cruzi importin beta-1 subunit, putative 0.0018 0.0144 0.0393
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0253 0.0253
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0044 0.0486 0.7801
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0016 0.0122 0.0232
Onchocerca volvulus 0.0053 0.061 0.1063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0039 0.042 0.1003
Loa Loa (eye worm) jmjC domain-containing protein 0.0046 0.0508 0.0531
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0095 0.0086
Trichomonas vaginalis DNA helicase recq1, putative 0.0014 0.0096 0.0081
Loa Loa (eye worm) runx1 0.0052 0.0596 0.0624
Schistosoma mansoni survival motor neuron protein 0.0053 0.061 0.061
Trypanosoma cruzi cdc2-related kinase 3 0.0278 0.3573 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0016 0.0122 0.0342
Echinococcus granulosus jumonji domain containing 1A 0.0011 0.0057 0.0049
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0253 0.0245
Echinococcus multilocularis lysine specific demethylase 6a 0.0011 0.0057 0.0049
Schistosoma mansoni hypothetical protein 0.0076 0.0908 0.0908
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0035 0.0365 0.1023
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0138 0.013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0253 0.0258
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0068 0.00000000022213
Trypanosoma brucei protein kinase, putative 0.0051 0.0579 0.1586
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0508 0.0508
Leishmania major basic transcription factor 3a, putative 0.0039 0.0416 0.1129
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0253 0.0253
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.0122 0.0332
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0474 0.0474
Trypanosoma cruzi cytochrome P450, putative 0.0008 0.0015 0.0031
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0253 0.0245
Schistosoma mansoni jumonji domain containing protein 0.0011 0.0057 0.0057
Plasmodium vivax importin-beta 2, putative 0.0022 0.0199 0.0557
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0253 0.0258
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0021 0.0181 0.2757
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0253 0.0245
Entamoeba histolytica recQ family DNA helicase 0.0007 0.0004 0.001
Brugia malayi hypothetical protein 0.001 0.004 0.0034
Mycobacterium leprae PROBABLE HYDROLASE 0.0021 0.0181 0.5503
Echinococcus multilocularis protocadherin 11 0.001 0.004 0.0032
Brugia malayi TAR-binding protein 0.0091 0.1114 0.1164
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0016 0.0122 0.0114
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.001 0.004 0.0032
Echinococcus multilocularis GPCR, family 2 0.0076 0.0908 0.09
Brugia malayi Cytochrome P450 family protein 0.0008 0.0015 0.0007
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0135 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0253 0.0258
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0016 0.0122 0.0342
Schistosoma mansoni tar DNA-binding protein 0.0091 0.1114 0.1114
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0044 0.0486 0.0478
Brugia malayi Protein kinase domain containing protein 0.0278 0.3573 0.3752
Echinococcus granulosus protocadherin 11 0.001 0.004 0.0032
Schistosoma mansoni zinc finger protein 0.0012 0.007 0.007
Onchocerca volvulus 0.003 0.03 0.0485
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0054 0.0619 0.1697
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0014 0.0087 0.0078
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0579 0.0579
Brugia malayi jmjC domain containing protein 0.0046 0.0508 0.0526
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0076 0.0908 0.09
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0018 0.0144 0.0217
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0868 0.2423
Brugia malayi nuclear hormone receptor family member nhr-6 0.0012 0.007 0.0065
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0278 0.3573 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0042 0.0468 0.046
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.061 0.0633
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0011 0.0057 0.0149
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0042 0.0468 0.046
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0012 0.007 0.007
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0011 0.0057 0.0159
Echinococcus multilocularis ccaat enhancer binding protein delta ccaat enhancer binding protein beta 0.001 0.004 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0132 0.0135
Brugia malayi RNA binding protein 0.0091 0.1114 0.1164
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0365 0.0985
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0868 0.2431
Leishmania major hypothetical protein, conserved 0.0011 0.0057 0.0118
Mycobacterium ulcerans aldehyde dehydrogenase 0.0044 0.0486 0.7801
Schistosoma mansoni transcription factor btf3 0.0039 0.0416 0.0416
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.0087 0.0053
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0868 0.091
Loa Loa (eye worm) Smad1 0.0008 0.0008 0.0005
Plasmodium falciparum histone acetyltransferase GCN5 0.0036 0.0377 0.091
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0253 0.0245
Treponema pallidum exodeoxyribonuclease (exoA) 0.0014 0.0087 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0011 0.0057 0.0057
Loa Loa (eye worm) DR-78 0.0012 0.007 0.007
Loa Loa (eye worm) TAR-binding protein 0.0091 0.1114 0.1169
Echinococcus multilocularis lamin dm0 0.003 0.03 0.0292
Brugia malayi Cell death specification protein 2 0.001 0.004 0.0034
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0044 0.0486 0.1324
Brugia malayi nuclear receptor NHR-88 0.0026 0.0253 0.0258
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.001 0.004 0.0032
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0097 0.0089
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0008 0.0008
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0365 0.0848
Echinococcus multilocularis cyclin dependent kinase 0.0278 0.3573 0.3567
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0253 0.0245
Brugia malayi acetyltransferase, GNAT family protein 0.0132 0.1649 0.1727
Echinococcus multilocularis 0.0008 0.0015 0.0007
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0012 0.007 0.0062
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0097 0.0089
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0868 0.2399
Schistosoma mansoni coup transcription factor 0.0026 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0579 0.0571
Brugia malayi nuclear hormone receptor family member odr-7 0.0012 0.007 0.0065
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0011 0.0057 0.0118
Loa Loa (eye worm) matrix metalloproteinase 0.0017 0.0132 0.0135
Toxoplasma gondii NAC domain-containing protein 0.0039 0.0416 0.1166
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.009 0.009
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0095 0.0086
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.009 0.0091
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0039 0.042 0.1174
Brugia malayi ubiquitin conjugating enzyme protein 13 0.021 0.2678 0.2811
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0062 0.0725 0.0717
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0014 0.0087 0.0131
Echinococcus multilocularis cyclin dependent kinase 5 0.0278 0.3573 0.3567
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0014 0.0087 0.0202
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0579 0.1459
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0253 0.0258
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.005 0.0571 0.0597
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0095 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0474 0.0467
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0253 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0416 0.0994
Schistosoma mansoni hypothetical protein 0.001 0.004 0.004
Plasmodium falciparum basic transcription factor 3b, putative 0.0039 0.0416 0.1023
Loa Loa (eye worm) MH2 domain-containing protein 0.0112 0.1387 0.1456
Schistosoma mansoni smad1 5 8 and 0.0008 0.0008 0.0008
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0095 0.0086
Loa Loa (eye worm) hypothetical protein 0.0014 0.0097 0.0098
Mycobacterium ulcerans aldehyde dehydrogenase 0.0044 0.0486 0.7801
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0579 0.0571
Schistosoma mansoni tar DNA-binding protein 0.0091 0.1114 0.1114
Schistosoma mansoni nuclear receptor 0.0012 0.007 0.007
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0021 0.0181 0.0182
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0008 0.0005
Toxoplasma gondii HEAT repeat-containing protein 0.0022 0.0199 0.0557
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0011 0.0057 0.0159
Loa Loa (eye worm) cytochrome P450 0.0008 0.0015 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0253 0.0262
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0579 0.1586
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0579 0.1613
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0017 0.0132 0.0132
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0096 0.0081
Brugia malayi cell division control protein 2 homolog 0.0278 0.3573 0.3752
Echinococcus multilocularis bloom syndrome protein 0.0014 0.0096 0.0088
Echinococcus granulosus histone lysine methyltransferase setb 0.0024 0.0225 0.0217
Plasmodium vivax SET domain protein, putative 0.0024 0.0225 0.063
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0014 0.0096 0.0088
Loa Loa (eye worm) hypothetical protein 0.0029 0.0293 0.0304
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.021 0.2678 0.2678
Toxoplasma gondii aldehyde dehydrogenase 0.0044 0.0486 0.136
Echinococcus granulosus lysine specific demethylase 5A 0.0046 0.0508 0.05
Schistosoma mansoni par domain protein 0.001 0.004 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0253 0.0262
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0007 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0727 0.9507 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0253 0.0258
Schistosoma mansoni nuclear hormone receptor 0.0012 0.007 0.007
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0068 0.00000000022213
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.0416 0.1129
Brugia malayi MH2 domain containing protein 0.0112 0.1387 0.1452
Schistosoma mansoni nuclear receptor 0.0012 0.007 0.007
Brugia malayi Matrixin family protein 0.0017 0.0132 0.0131
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0012 0.007 0.0065
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0579 0.0606
Loa Loa (eye worm) intermediate filament protein 0.003 0.03 0.0312
Schistosoma mansoni transcriptional factor nfil3/e4bp4 0.001 0.004 0.004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.001 0.004 0.0032
Entamoeba histolytica hypothetical protein 0.0085 0.1025 0.287
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0225 0.0225
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0508 0.0508
Brugia malayi Calcitonin receptor-like protein seb-1 0.024 0.3069 0.3222
Brugia malayi hypothetical protein 0.0261 0.335 0.3518
Echinococcus granulosus bloom syndrome protein 0.0014 0.0096 0.0088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0039
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0868 0.0861
Echinococcus granulosus tar DNA binding protein 0.0091 0.1114 0.1107
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0868 0.0861
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0118 0.0115
Onchocerca volvulus 0.0012 0.007 0.0056
Schistosoma mansoni lozenge 0.0052 0.0596 0.0596
Echinococcus multilocularis snurportin 1 0.0236 0.3021 0.3016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0056
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0096 0.0259
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.1304 0.3649
Echinococcus granulosus GTP binding nuclear protein Ran 0.0016 0.0122 0.0114
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.007 0.0062
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0096 0.0093
Loa Loa (eye worm) nuclear hormone receptor 0.0012 0.007 0.007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0014 0.0087 0.0232
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0096 0.0229
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0253 0.0253
Brugia malayi Matrixin family protein 0.0041 0.0451 0.0466
Brugia malayi nuclear hormone receptor 0.0026 0.0253 0.0258
Loa Loa (eye worm) hypothetical protein 0.0017 0.0132 0.0135
Entamoeba histolytica hypothetical protein 0.001 0.004 0.0113
Echinococcus granulosus histone acetyltransferase KAT2B 0.0128 0.16 0.1593
Echinococcus multilocularis inositol monophosphatase 1 0.0035 0.0365 0.0357
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0278 0.3573 0.3755
Echinococcus granulosus intermediate filament protein 0.003 0.03 0.0292
Trichomonas vaginalis CMGC family protein kinase 0.0278 0.3573 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0416 0.0994
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Brugia malayi intermediate filament protein 0.003 0.03 0.0307
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0039
Trypanosoma cruzi cdc2-related kinase 1 0.0278 0.3573 1
Schistosoma mansoni microtubule-associated protein tau 0.0761 0.9954 0.9954
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0474 0.0467
Schistosoma mansoni hypothetical protein 0.0236 0.3021 0.3021
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0619 0.0643
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0014 0.0096 0.0097
Brugia malayi hypothetical protein 0.0014 0.009 0.0086
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0057 0.0056
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.021 0.2678 0.2811
Onchocerca volvulus 0.0416 0.5398 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0253 0.0253
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.0122 0.0332
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0014 0.0096 0.0088
Loa Loa (eye worm) hypothetical protein 0.0022 0.0199 0.0206
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0474 0.0467
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0091 0.1114 0.1169
Loa Loa (eye worm) RecQ helicase 0.0014 0.0096 0.0097
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0091
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0096 0.0093
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0138 0.0141
Loa Loa (eye worm) latrophilin receptor protein 2 0.0076 0.0908 0.0951
Loa Loa (eye worm) ICD-1 protein 0.0039 0.0416 0.0434
Echinococcus granulosus microtubule associated protein 2 0.0761 0.9954 0.9954
Schistosoma mansoni DNA helicase recq1 0.0014 0.0096 0.0096
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0096 0.0269
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0727 0.9507 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.007 0.0062
Schistosoma mansoni cytochrome P450 0.0008 0.0015 0.0015
Trichomonas vaginalis ran, putative 0.0016 0.0122 0.0154
Schistosoma mansoni smad 0.0008 0.0008 0.0008
Entamoeba histolytica Ran family GTPase 0.0016 0.0122 0.0342
Echinococcus granulosus cyclin dependent kinase 0.0278 0.3573 0.3567
Schistosoma mansoni ap endonuclease 0.0014 0.0087 0.0087
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0011 0.0057 0.0149
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0016 0.0122 0.012
Echinococcus multilocularis transcriptional factor nfil3:e4bp4 0.001 0.004 0.0032
Echinococcus granulosus snurportin 1 0.0236 0.3021 0.3016
Entamoeba histolytica hypothetical protein 0.0085 0.1025 0.287
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0253 0.0258
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0253 0.0258
Echinococcus multilocularis tar DNA binding protein 0.0091 0.1114 0.1107
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0253 0.0245
Echinococcus granulosus importin subunit beta 1 0.0022 0.0199 0.0191
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0014 0.0096 0.0088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0236 0.3021 0.3175
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0056
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0579 0.1526
Trichomonas vaginalis CMGC family protein kinase 0.0278 0.3573 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0096 0.0097
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.021 0.2678 0.7486
Echinococcus multilocularis cyclin dependent kinase 1 0.0278 0.3573 0.3567
Entamoeba histolytica hypothetical protein 0.0085 0.1025 0.287
Schistosoma mansoni intermediate filament proteins 0.003 0.03 0.03
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0253 0.0262
Brugia malayi Cell death specification protein 2 0.001 0.004 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0253 0.0258
Echinococcus granulosus phd:f box containing protein 0.0011 0.0057 0.0049
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.007 0.0056
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.009 0.0082
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0253 0.0397
Toxoplasma gondii cytochrome p450 superfamily protein 0.0008 0.0015 0.0042
Echinococcus granulosus X box binding protein 1 0.0318 0.4102 0.4097
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0014 0.0087 0.0232
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0012 0.007 0.007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0043 0.0474 0.0495
Brugia malayi nuclear hormone receptor 0.0012 0.007 0.0065
Loa Loa (eye worm) bZIP transcription factor family protein 0.001 0.004 0.0039
Schistosoma mansoni lamin 0.003 0.03 0.03
Onchocerca volvulus 0.003 0.03 0.0485
Trypanosoma brucei ubiquitin-protein ligase, putative 0.021 0.2678 0.7486
Echinococcus multilocularis cyclin dependent kinase 1 0.0278 0.3573 0.3567
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.001 0.0033 0.0052
Onchocerca volvulus 0.0054 0.0616 0.1075
Brugia malayi Cell death specification protein 2 0.001 0.004 0.0034
Brugia malayi nuclear receptor RXR 0.0012 0.007 0.0065
Onchocerca volvulus Matrilysin homolog 0.0017 0.0132 0.0172
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0272 0.3502 0.3681
Onchocerca volvulus 0.0024 0.0225 0.0345
Trichomonas vaginalis inositol monophosphatase, putative 0.0035 0.0365 0.0848
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Echinococcus granulosus cyclin dependent kinase 5 0.0278 0.3573 0.3567
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0096 0.0229
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.007 0.0062
Leishmania major GTP-binding protein, putative 0.0016 0.0122 0.0302
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0039
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.0416 0.1166
Loa Loa (eye worm) cell death specification protein 2 0.001 0.004 0.0039
Schistosoma mansoni cpg binding protein 0.0057 0.0656 0.0656
Schistosoma mansoni aldehyde dehydrogenase 0.0044 0.0486 0.0486
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.0087 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0253 0.0258
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0474 0.0467
Schistosoma mansoni hypothetical protein 0.0053 0.061 0.061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0225 0.0225
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0138 0.013
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0014 0.0087 0.0087
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0132 0.1649 0.1642
Echinococcus multilocularis thyroid hormone receptor alpha 0.0026 0.0253 0.0245
Brugia malayi hypothetical protein 0.0416 0.5398 0.5674
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0365 0.1013
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0253 0.0262
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.021 0.2678 0.7448
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.021 0.2678 0.2672
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0253 0.0397
Schistosoma mansoni hypothetical protein 0.0164 0.2069 0.2069
Trypanosoma cruzi cdc2-related kinase 1 0.0278 0.3573 1
Plasmodium vivax protein kinase Crk2 0.0278 0.3573 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.2069 0.2173
Schistosoma mansoni hypothetical protein 0.0076 0.0908 0.0908
Schistosoma mansoni aldehyde dehydrogenase 0.0044 0.0486 0.0486
Brugia malayi Pre-SET motif family protein 0.0024 0.0225 0.0228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Brugia malayi Latrophilin receptor protein 2 0.0076 0.0908 0.0947
Entamoeba histolytica acetyltransferase, GNAT family 0.0036 0.0377 0.1055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0253 0.0262
Schistosoma mansoni blooms syndrome DNA helicase 0.0007 0.0004 0.0004
Brugia malayi Pre-SET motif family protein 0.0161 0.2028 0.2127
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0054 0.0619 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0579 0.1459
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.0087 0.0242
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0579 0.1613
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.007 0.0062
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0054 0.0619 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0253 0.0262
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0579 0.1586
Brugia malayi beta-NAC-like protein 0.0039 0.0416 0.043
Echinococcus granulosus cytochrome P450 2K1 0.0008 0.0015 0.0007
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0039 0.042 0.1174
Brugia malayi Nuclear hormone receptor E75 0.0012 0.007 0.0065
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0253 0.0258
Schistosoma mansoni transcription factor LCR-F1 0.0085 0.1025 0.1025
Echinococcus granulosus GPCR family 2 0.0076 0.0908 0.09
Echinococcus granulosus transcriptional factor nfil3:e4bp4 0.001 0.004 0.0032
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0253 0.0397
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0579 0.1621
Brugia malayi latrophilin 2 splice variant baaae 0.0164 0.2069 0.2169
Echinococcus granulosus lysine specific demethylase 6a 0.0011 0.0057 0.0049
Brugia malayi RNA recognition motif domain containing protein 0.0091 0.1114 0.1164
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0039
Brugia malayi Inositol-1 0.0035 0.0365 0.0376
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0039 0.042 0.1003
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0015 0.0012
Entamoeba histolytica hypothetical protein 0.0018 0.0144 0.0403
Onchocerca volvulus 0.0024 0.0226 0.0347
Echinococcus multilocularis phd:f box containing protein 0.0011 0.0057 0.0049
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0091
Schistosoma mansoni ap endonuclease 0.0014 0.0087 0.0087
Trichomonas vaginalis set domain proteins, putative 0.0183 0.2319 0.6424
Echinococcus multilocularis microtubule associated protein 2 0.0761 0.9954 0.9954
Schistosoma mansoni inositol monophosphatase 0.0035 0.0365 0.0365
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0014 0.0087 0.1188
Brugia malayi nuclear receptor NHR-67 0.0012 0.007 0.0065
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0012 0.007 0.0062
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Giardia lamblia Sgs1 DNA helicase, putative 0.0014 0.0096 0.0158
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0062 0.0725 0.0717
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0008 0.0015 0.0031
Loa Loa (eye worm) hypothetical protein 0.0416 0.5398 0.5676
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0091
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0012 0.007 0.0062
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0579 0.1459
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.021 0.2678 0.7496
Loa Loa (eye worm) pigment dispersing factor receptor c 0.024 0.3069 0.3225
Echinococcus granulosus cpg binding protein 0.0057 0.0656 0.0649
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0054 0.0619 0.0619
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0253 0.0258
Brugia malayi orphan nuclear receptor NR2E1 0.0012 0.007 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0225 0.0225
Brugia malayi Matrixin family protein 0.0017 0.0132 0.0131
Schistosoma mansoni hypothetical protein 0.0008 0.0015 0.0015
Brugia malayi ecdysone receptor 0.0012 0.007 0.0065
Schistosoma mansoni importin beta-1 0.0022 0.0199 0.0199
Schistosoma mansoni nuclear hormone receptor 0.0012 0.007 0.007
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0579 0.0571
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.021 0.2678 0.7494
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0014 0.0096 0.0112
Brugia malayi MAP kinase sur-1 0.0051 0.0579 0.0601
Brugia malayi Matrixin family protein 0.0017 0.0132 0.0131
Brugia malayi Cytochrome P450 family protein 0.0008 0.0015 0.0007
Trichomonas vaginalis importin beta-1, putative 0.0018 0.0144 0.0217
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Echinococcus multilocularis dnaJ subfamily B 0.0765 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0012 0.007 0.007
Brugia malayi hypothetical protein 0.001 0.004 0.0034
Giardia lamblia Kinase, CMGC CDK 0.0278 0.3573 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0253 0.0262
Echinococcus granulosus JmjC domain containing protein 4 0.0011 0.0057 0.0049
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.0087 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.3573 0.3573
Echinococcus multilocularis lamin 0.003 0.03 0.0292
Schistosoma mansoni hypothetical protein 0.0085 0.1025 0.1025
Giardia lamblia Histone acetyltransferase GCN5 0.0036 0.0377 0.0953
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0253 0.0245
Plasmodium falciparum importin beta, putative 0.0022 0.0199 0.0405
Echinococcus multilocularis cpg binding protein 0.0057 0.0656 0.0649
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0225 0.0225
Entamoeba histolytica hypothetical protein 0.0039 0.0416 0.1166
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0068 0.00000000022213
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0464 0.0456
Brugia malayi Bloom's syndrome protein homolog 0.0014 0.0096 0.0093
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0868 0.2399
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.009 0.0082
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0044 0.0486 0.0478
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.03 0.0307
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0416 0.1157
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0035 0.0365 0.1023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0068 0.00000000022213
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0585 0.7632 0.763
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0042 0.0468 0.046
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Brugia malayi bZIP transcription factor family protein 0.001 0.004 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.3573 0.3573
Echinococcus multilocularis protocadherin 11 0.001 0.004 0.0032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0253 0.0253
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0091
Echinococcus multilocularis Protein lozenge 0.0052 0.0596 0.0588
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0039 0.042 0.1174
Entamoeba histolytica hypothetical protein 0.0085 0.1025 0.287
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0579 0.1613
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.007 0.0056
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.021 0.2678 0.2814
Plasmodium falciparum protein kinase 5 0.0278 0.3573 1
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.021 0.2678 0.7496
Loa Loa (eye worm) matrixin family protein 0.0038 0.0406 0.0424
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0043 0.0474 0.0491
Loa Loa (eye worm) hypothetical protein 0.0026 0.0253 0.0262
Loa Loa (eye worm) CXXC zinc finger family protein 0.0054 0.0616 0.0644
Schistosoma mansoni smad1 5 8 and 0.0008 0.0008 0.0008
Loa Loa (eye worm) transcription factor SMAD2 0.0112 0.1387 0.1456
Echinococcus multilocularis X box binding protein 1 0.0318 0.4102 0.4097
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0564 0.7346 0.7344
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0132 0.1649 0.1649
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0014 0.0087 0.1188
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0579 0.1459
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.021 0.2678 0.2814
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0057 0.0056
Echinococcus granulosus transcription factor btf3 0.0039 0.0416 0.0409
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0278 0.3573 0.3755
Schistosoma mansoni jumonji domain containing protein 0.0042 0.0468 0.0468
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0253 0.0245
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0014 0.0087 0.0078
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0579 0.1613
Echinococcus granulosus lamin 0.003 0.03 0.0292
Loa Loa (eye worm) hypothetical protein 0.0076 0.0908 0.0951
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0253 0.0245
Schistosoma mansoni tar DNA-binding protein 0.0091 0.1114 0.1114
Trypanosoma brucei cdc2-related kinase 3 0.0278 0.3573 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0868 0.0868
Brugia malayi Importin beta-1 subunit 0.0022 0.0199 0.0201
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0035 0.0365 1
Echinococcus multilocularis musashi 0.003 0.03 0.0292
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.001 0.004 0.0032
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.021 0.2678 0.7494
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0014 0.0096 0.0112
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0016 0.0122 0.0125
Loa Loa (eye worm) hypothetical protein 0.0024 0.0225 0.0233
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0008 0.0015 0.0031
Entamoeba histolytica cell division protein kinase 2, putative 0.0278 0.3573 1
Schistosoma mansoni hypothetical protein 0.0765 1 1
Brugia malayi Matrixin family protein 0.0017 0.0132 0.0131
Schistosoma mansoni Smad4 0.0008 0.0008 0.0008
Brugia malayi cytochrome P450 0.0008 0.0015 0.0007
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0016 0.0122 0.0302
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0253 0.0245
Brugia malayi conserved hypotetical protein 0.0012 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.000000000081912
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0253 0.0258
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0579 0.0571
Loa Loa (eye worm) matrixin family protein 0.0041 0.0451 0.0471
Loa Loa (eye worm) hypothetical protein 0.0416 0.5398 0.5676
Echinococcus granulosus histone acetyltransferase KAT2B 0.0039 0.042 0.0412
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0085 0.1025 0.1018
Echinococcus granulosus cyclin dependent kinase 1 0.0278 0.3573 0.3567
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0365 0.1013
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0014 0.0087 0.0242
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0318 0.4102 0.4102
Loa Loa (eye worm) hypothetical protein 0.0014 0.009 0.0091
Giardia lamblia Kinase, CMGC CDK 0.0278 0.3573 1
Schistosoma mansoni inositol monophosphatase 0.0035 0.0365 0.0365
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0076 0.0908 0.0947
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Loa Loa (eye worm) RNA binding protein 0.0091 0.1114 0.1169
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0253 0.0258
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0253 0.0245
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.001 0.004 0.0032
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0253 0.0253
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0225 0.063
Brugia malayi hypothetical protein 0.0012 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.007
Brugia malayi tailless protein 0.0012 0.007 0.0065
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0008 0.0005
Loa Loa (eye worm) nuclear receptor NHR-67 0.0012 0.007 0.007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0068 0.00000000022213
Mycobacterium ulcerans aldehyde dehydrogenase 0.0044 0.0486 0.7801
Echinococcus multilocularis jumonji domain containing 1A 0.0011 0.0057 0.0049
Brugia malayi hypothetical protein 0.0012 0.007 0.0065
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.007 0.0062
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.004 0.0441 0.0441
Schistosoma mansoni lamin 0.003 0.03 0.03
Brugia malayi Hemopexin family protein 0.0024 0.0226 0.0229
Schistosoma mansoni phd/f-box containing protein 0.0011 0.0057 0.0057
Trypanosoma brucei importin beta-1 subunit, putative 0.0022 0.0199 0.0518
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0253 0.0253
Trypanosoma cruzi cytochrome P450, putative 0.0008 0.0015 0.0031
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0253 0.0245
Echinococcus granulosus lamin dm0 0.003 0.03 0.0292
Loa Loa (eye worm) hypothetical protein 0.003 0.03 0.0312
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0022 0.0198 0.019
Loa Loa (eye worm) acetyltransferase 0.0132 0.1649 0.1731
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0115 0.1422 0.1422
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0085 0.1025 0.1018
Schistosoma mansoni hypothetical protein 0.0076 0.0908 0.0908
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0464 0.0456
Brugia malayi Hepatic leukemia factor 0.001 0.004 0.0034
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0095 0.0095
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0096 0.0081
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0278 0.3573 0.3755
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0118 0.012
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0253 0.0253
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0278 0.3573 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0068 0.00000000022213
Echinococcus multilocularis importin subunit beta 1 0.0022 0.0199 0.0191
Brugia malayi hypothetical protein 0.001 0.004 0.0034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0024 0.0225 0.0217
Brugia malayi jmjC domain containing protein 0.0011 0.0057 0.0051
Schistosoma mansoni protein phosphatase 2C 0.0011 0.0057 0.0057
Brugia malayi Nuclear hormone receptor E75 0.0012 0.007 0.0065
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.021 0.2678 0.7456
Mycobacterium ulcerans hydrolase 0.0021 0.0181 0.2757

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 300 uM Inhibitory activity against Oxidosqualene-lanosterol cyclase in pig liver ChEMBL. 2769687
IC50 (binding) = 300 uM Inhibitory activity against Oxidosqualene-lanosterol cyclase in pig liver ChEMBL. 2769687
IC50 (binding) > 400 uM Inhibitory activity against Squalene Epoxidase in pig liver ChEMBL. 2769687
IC50 (binding) > 400 uM Inhibitory activity against Squalene Epoxidase in pig liver ChEMBL. 2769687

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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