Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0057 | 0.0085 | 0.0938 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0042 | 0.0036 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.1194 | 0.1194 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0057 | 0.0085 | 0.1106 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0057 | 0.0085 | 0.1106 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0156 | 0.0423 | 0.3959 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1451 | 0.4815 | 0.539 |
Schistosoma mansoni | hypothetical protein | 0.0315 | 0.0961 | 0.1995 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0057 | 0.0084 | 0.0497 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0042 | 0.0036 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0322 | 0.0983 | 0.2042 |
Schistosoma mansoni | protein kinase | 0.0391 | 0.1217 | 0.2528 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0057 | 0.0085 | 0.0938 |
Trypanosoma brucei | cytochrome P450, putative | 0.0198 | 0.0563 | 0.5557 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.002 | 0.002 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0057 | 0.0085 | 0.1106 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0057 | 0.0085 | 0.0938 |
Brugia malayi | Cytochrome P450 family protein | 0.0198 | 0.0563 | 0.0563 |
Schistosoma mansoni | protein kinase | 0.0315 | 0.0961 | 0.1995 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0056 | 0.0083 | 0.9728 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0042 | 0.0036 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0198 | 0.0563 | 0.0563 |
Entamoeba histolytica | hypothetical protein | 0.0315 | 0.0961 | 0.7829 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 0.0339 | 0.0339 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0056 | 0.0083 | 0.0399 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0057 | 0.0085 | 0.0938 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0057 | 0.0085 | 0.0506 |
Schistosoma mansoni | hypothetical protein | 0.0584 | 0.1873 | 0.389 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1825 | 0.6083 | 0.6811 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0083 | 0.0399 |
Schistosoma mansoni | ap endonuclease | 0.0042 | 0.0036 | 0.0074 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0057 | 0.0085 | 0.1106 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0054 | 0.0074 | 0.0154 |
Echinococcus multilocularis | geminin | 0.0584 | 0.1873 | 0.2097 |
Echinococcus granulosus | PAK box P21 Rho binding | 0.0315 | 0.0961 | 0.1075 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0056 | 0.0083 | 0.0482 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0391 | 0.1217 | 0.1363 |
Echinococcus granulosus | snurportin 1 | 0.0339 | 0.1044 | 0.1168 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0315 | 0.0961 | 0.0961 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0057 | 0.0085 | 0.1106 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0057 | 0.0085 | 0.0938 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0079 | 0.0079 |
Echinococcus granulosus | microtubule associated protein 2 | 0.1451 | 0.4815 | 0.539 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0057 | 0.0085 | 0.1106 |
Leishmania major | cytochrome p450-like protein | 0.0057 | 0.0085 | 0.0506 |
Loa Loa (eye worm) | P21-Rho-binding domain-containing protein | 0.0315 | 0.0961 | 0.0961 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0057 | 0.0085 | 0.1106 |
Echinococcus granulosus | geminin | 0.0584 | 0.1873 | 0.2097 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0057 | 0.0085 | 0.1106 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0331 | 0.1013 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0339 | 0.1044 | 0.1168 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0198 | 0.0563 | 0.5395 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0057 | 0.0085 | 0.1106 |
Brugia malayi | WH1 domain containing protein | 0.0315 | 0.0961 | 0.0961 |
Brugia malayi | MAP kinase sur-1 | 0.0056 | 0.0083 | 0.0083 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0057 | 0.0085 | 0.0938 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0315 | 0.0961 | 0.1075 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0076 | 0.0149 | 0.0309 |
Brugia malayi | RNA, U transporter 1 | 0.009 | 0.0199 | 0.0199 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0056 | 0.0083 | 0.0093 |
Schistosoma mansoni | hypothetical protein | 0.0315 | 0.0961 | 0.1995 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0057 | 0.0085 | 0.0938 |
Entamoeba histolytica | protein kinase, putative | 0.0322 | 0.0983 | 0.802 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0057 | 0.0085 | 0.1106 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0391 | 0.1217 | 0.1363 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0057 | 0.0085 | 0.0938 |
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.0076 | 0.0149 | 0.0955 |
Schistosoma mansoni | hypothetical protein | 0.0584 | 0.1873 | 0.389 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0057 | 0.0085 | 0.1106 |
Echinococcus multilocularis | neural Wiskott Aldrich syndrome protein | 0.0315 | 0.0961 | 0.1075 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0057 | 0.0085 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0391 | 0.1217 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0056 | 0.0083 | 0.0818 |
Trichomonas vaginalis | STE family protein kinase | 0.0391 | 0.1217 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0079 | 0.0079 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0057 | 0.0085 | 0.0938 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0198 | 0.0563 | 0.0563 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0174 | 0.0483 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0057 | 0.0085 | 0.0085 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0057 | 0.0085 | 0.0938 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.037 | 0.037 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0391 | 0.1217 | 0.1363 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0057 | 0.0085 | 0.0841 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0057 | 0.0085 | 0.0506 |
Loa Loa (eye worm) | cytochrome P450 | 0.0057 | 0.0085 | 0.0085 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0057 | 0.0085 | 0.0938 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0056 | 0.0083 | 0.0482 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0315 | 0.0961 | 0.0961 |
Schistosoma mansoni | cytochrome P450 | 0.0057 | 0.0085 | 0.0177 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 0.0083 | 0.0482 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0079 | 0.0079 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0042 | 0.0036 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0042 | 0.0036 | 0.004 |
Brugia malayi | MH2 domain containing protein | 0.0132 | 0.0339 | 0.0339 |
Giardia lamblia | Kinase, STE STE20 | 0.0391 | 0.1217 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0046 | 0.005 | 0.0491 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.0076 | 0.0149 | 0.0149 |
Brugia malayi | Protein kinase domain | 0.0391 | 0.1217 | 0.1217 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0056 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0076 | 0.0149 | 0.0149 |
Schistosoma mansoni | wiskott-aldrich syndrome protein | 0.0315 | 0.0961 | 0.1995 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0057 | 0.0085 | 0.0938 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 0.0339 | 0.0339 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0056 | 0.0083 | 0.0093 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0331 | 0.1013 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.0083 | 0.0172 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0056 | 0.0083 | 0.0482 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0384 | 0.1194 | 0.9809 |
Mycobacterium leprae | putative cytochrome p450 | 0.0057 | 0.0085 | 0.5 |
Echinococcus granulosus | neural Wiskott Aldrich syndrome protein | 0.0315 | 0.0961 | 0.1075 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0046 | 0.005 | 0.0144 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0046 | 0.005 | 0.0144 |
Schistosoma mansoni | hypothetical protein | 0.0315 | 0.0961 | 0.1995 |
Echinococcus granulosus | serine:threonine protein kinase PAK 1 | 0.0069 | 0.0126 | 0.0141 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0057 | 0.0085 | 0.0506 |
Schistosoma mansoni | protein kinase | 0.0391 | 0.1217 | 0.2528 |
Schistosoma mansoni | ap endonuclease | 0.0042 | 0.0036 | 0.0074 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0083 | 0.0399 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0085 | 0.0177 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0076 | 0.0149 | 0.1154 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0057 | 0.0085 | 0.0938 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1451 | 0.4815 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0057 | 0.0085 | 0.0506 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0057 | 0.0085 | 0.1106 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.2665 | 0.8932 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0057 | 0.0085 | 0.0095 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0083 | 0.0399 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0391 | 0.1217 | 0.1363 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0057 | 0.0085 | 0.0938 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0046 | 0.005 | 0.0144 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0057 | 0.0085 | 0.0938 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0057 | 0.0085 | 0.1106 |
Entamoeba histolytica | protein kinase, putative | 0.0322 | 0.0983 | 0.802 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0391 | 0.1217 | 0.1363 |
Echinococcus multilocularis | 0.0057 | 0.0085 | 0.0095 | |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0057 | 0.0085 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0331 | 0.1013 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0074 | 0.0074 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0057 | 0.0085 | 0.1106 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0056 | 0.0083 | 0.0399 |
Trichomonas vaginalis | STE family protein kinase | 0.0391 | 0.1217 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.2665 | 0.8932 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0391 | 0.1217 | 0.1363 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0156 | 0.0423 | 0.4172 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.0076 | 0.0149 | 0.1154 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0057 | 0.0085 | 0.1106 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0042 | 0.0036 | 0.004 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.298 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0198 | 0.0563 | 0.5395 |
Echinococcus granulosus | tumor protein p63 | 0.0367 | 0.1136 | 0.1272 |
Brugia malayi | Cytochrome P450 family protein | 0.0198 | 0.0563 | 0.0563 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0057 | 0.0085 | 0.0938 |
Schistosoma mansoni | hypothetical protein | 0.0339 | 0.1044 | 0.2168 |
Trichomonas vaginalis | STE family protein kinase | 0.0391 | 0.1217 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0076 | 0.0149 | 0.0309 |
Echinococcus granulosus | 3'partial|serine:threonine protein kinase PAK 2 | 0.0315 | 0.0961 | 0.1075 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0057 | 0.0085 | 0.1106 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0057 | 0.0085 | 0.0506 |
Toxoplasma gondii | hypothetical protein | 0.0053 | 0.0073 | 0.8567 |
Schistosoma mansoni | tyrosine kinase | 0.0315 | 0.0961 | 0.1995 |
Entamoeba histolytica | protein kinase, putative | 0.0322 | 0.0983 | 0.802 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0057 | 0.0085 | 0.0938 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0056 | 0.0083 | 0.0482 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.002 | 0.0041 |
Entamoeba histolytica | hypothetical protein | 0.0315 | 0.0961 | 0.7829 |
Trichomonas vaginalis | STE family protein kinase | 0.0391 | 0.1217 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0042 | 0.0036 | 0.4194 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0057 | 0.0085 | 0.0938 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0042 | 0.0036 | 0.0036 |
Trypanosoma brucei | protein kinase, putative | 0.0056 | 0.0083 | 0.0818 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0042 | 0.0036 | 0.0036 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0056 | 0.0083 | 0.0093 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0057 | 0.0085 | 0.0938 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0056 | 0.0083 | 0.0482 |
Trichomonas vaginalis | STE family protein kinase | 0.0322 | 0.0983 | 0.802 |
Leishmania major | cytochrome p450-like protein | 0.0198 | 0.0563 | 0.5395 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0057 | 0.0085 | 0.0938 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0057 | 0.0085 | 0.0085 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0056 | 0.0083 | 0.0093 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0057 | 0.0085 | 0.1106 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0057 | 0.0085 | 0.1106 |
Mycobacterium ulcerans | hypothetical protein | 0.0174 | 0.0483 | 0.8476 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0198 | 0.0563 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0076 | 0.0149 | 0.0149 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.002 | 0.002 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0315 | 0.0961 | 0.1995 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0042 | 0.0036 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0331 | 0.1013 | 1 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0322 | 0.0983 | 0.1101 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0198 | 0.0563 | 0.0563 |
Brugia malayi | Cytochrome P450 family protein | 0.0057 | 0.0085 | 0.0085 |
Entamoeba histolytica | p21-activated kinase | 0.0391 | 0.1217 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0367 | 0.1136 | 0.1272 |
Onchocerca volvulus | 0.0054 | 0.0074 | 0.5 | |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0057 | 0.0085 | 0.1106 |
Brugia malayi | cytochrome P450 | 0.0057 | 0.0085 | 0.0085 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0156 | 0.0423 | 0.3959 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0339 | 0.1044 | 0.1044 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0057 | 0.0085 | 0.1106 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.