TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 528.733 | Formula: C26H36N6O2S2
H donors: 2 H acceptors: 4 LogP: 5.61 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: O=C(CN(C1CCCCC1)C)Nc1sc2c(n1)cc1c(c2)sc(n1)NC(=O)CN(C1CCCCC1)C
InChi: 1S/C26H36N6O2S2/c1-31(17-9-5-3-6-10-17)15-23(33)29-25-27-19-13-20-22(14-21(19)35-25)36-26(28-20)30-24(34)16-32(2)18-11-7-4-8-12-18/h13-14,17-18H,3-12,15-16H2,1-2H3,(H,27,29,33)(H,28,30,34)
InChiKey: AHPHYTWVDMTUKF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	neuropeptide receptor	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Echinococcus multilocularis	neuropeptide Y receptor	0.0027	0.002	0.0016
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0053	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Toxoplasma gondii	hypothetical protein	0.0066	0.0092	1
Echinococcus multilocularis	fucosidase, alpha L 1, tissue	0.0423	0.0741	0.0736
Trichomonas vaginalis	DNA polymerase eta, putative	0.0021	0.001	0.0038
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0027	0.002	0.0016
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0027	0.002	0.0016
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0066	0.0092	0.0087
Onchocerca volvulus	Glucosylceramidase homolog	0.0505	0.0889	0.087
Echinococcus multilocularis	G protein coupled receptor 139	0.0027	0.002	0.0016
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0066	0.0092	0.0087
Brugia malayi	Thioredoxin reductase	0.0052	0.0067	0.0062
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0066	0.0092	0.0087
Schistosoma mansoni	amine GPCR	0.0027	0.002	0.0016
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0066	0.0092	0.0087
Schistosoma mansoni	neuropeptide F-like receptor	0.0027	0.002	0.0016
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0009	0.0031
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0066	0.0091	0.0633
Schistosoma mansoni	opsin-like receptor	0.0027	0.002	0.0016
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.001	0.0006
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0067	0.0062
Echinococcus granulosus	sodium and chloride dependent glycine	0.0066	0.0092	0.0087
Onchocerca volvulus		0.0388	0.0677	0.0658
Schistosoma mansoni	opsin-like receptor	0.0027	0.002	0.0016
Echinococcus granulosus	somatostatin receptor	0.0027	0.002	0.0016
Echinococcus multilocularis	neuropeptide s receptor	0.0027	0.002	0.0016
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0294	0.0506	0.0502
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0009	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0009	0.0063
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0066	0.0092	0.0087
Echinococcus granulosus	neuropeptides capa receptor	0.0027	0.002	0.0016
Brugia malayi	putative neuropeptide receptor NPR1	0.0027	0.002	0.0016
Brugia malayi	hypothetical protein	0.0027	0.002	0.0016
Mycobacterium tuberculosis	Probable reductase	0.0119	0.0188	0.7812
Brugia malayi	RE15519p	0.0027	0.002	0.0016
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.002	0.0016
Echinococcus granulosus	g protein coupled receptor	0.0027	0.002	0.0016
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0341	0.0591	0.4296
Trichomonas vaginalis	glucosylceramidase, putative	0.0505	0.0889	0.6479
Schistosoma mansoni	biogenic amine receptor	0.0027	0.002	0.0016
Schistosoma mansoni	ap endonuclease	0.002	0.0009	0.0004
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0053	0.0048
Trichomonas vaginalis	DNA helicase recq1, putative	0.0023	0.0014	0.0067
Echinococcus granulosus	survival motor neuron protein 1	0.0257	0.0438	0.0434
Echinococcus granulosus	neuropeptide Y receptor	0.0027	0.002	0.0016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.002	0.0016
Echinococcus multilocularis	g protein coupled receptor	0.0027	0.002	0.0016
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.002	0.0016
Schistosoma mansoni	biogenic amine receptor	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0092	0.0086
Schistosoma mansoni	vesicular acetylcholine transporter	0.5517	1	1
Echinococcus multilocularis	allatostatin A receptor	0.0027	0.002	0.0016
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0066	0.0091	0.0086
Echinococcus multilocularis	neuropeptides capa receptor	0.0027	0.002	0.0016
Schistosoma mansoni	vesicular amine transporter	0.0576	0.1019	0.1014
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Loa Loa (eye worm)	thioredoxin reductase	0.0052	0.0067	0.0061
Brugia malayi	G-protein coupled receptor	0.0027	0.002	0.0016
Echinococcus granulosus	beta galactosidase	0.0138	0.0223	0.0219
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0027	0.002	0.0016
Echinococcus multilocularis	glycogen phosphorylase	0.0341	0.0591	0.0587
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0052	0.0067	0.2639
Brugia malayi	Serotonin receptor	0.0027	0.002	0.0016
Echinococcus multilocularis	bloom syndrome protein	0.0023	0.0014	0.0009
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0066	0.0092	0.0087
Onchocerca volvulus		0.0052	0.0067	0.0047
Trichomonas vaginalis	glucosylceramidase, putative	0.0769	0.137	1
Leishmania major	trypanothione reductase	0.0052	0.0067	0.0074
Schistosoma mansoni	alpha glucosidase	0.0066	0.0091	0.0086
Brugia malayi	hypothetical protein	0.0027	0.002	0.0016
Schistosoma mansoni	DNA polymerase eta	0.0021	0.001	0.0005
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0388	0.0677	0.0672
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.001	0.0006
Onchocerca volvulus		0.0066	0.0092	0.0071
Schistosoma mansoni	biogenic amine receptor	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0092	0.0086
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0294	0.0506	0.0502
Echinococcus granulosus	neuropeptide FF receptor 2	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0049	0.5298
Trichomonas vaginalis	glucosylceramidase, putative	0.0769	0.137	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0092	0.0086
Echinococcus granulosus	Glycosyl transferase family 35	0.0341	0.0591	0.0587
Echinococcus granulosus	sex peptide receptor	0.0027	0.002	0.0016
Echinococcus granulosus	g-protein coupled receptor	0.0027	0.002	0.0016
Entamoeba histolytica	glycogen phosphorylase, putative	0.0147	0.024	0.3962
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0066	0.0092	0.0087
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0119	0.0188	0.7812
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0066	0.0092	0.0086
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0027	0.002	0.0016
Trichomonas vaginalis	alpha-glucosidase, putative	0.0066	0.0091	0.0633
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0027	0.002	0.0016
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0041	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Onchocerca volvulus		0.0267	0.0456	0.0437
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0006
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0038	0.0041	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0042	0.0049	0.5059
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Brugia malayi	hypothetical protein	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Echinococcus multilocularis	neuropeptide receptor A26	0.0027	0.002	0.0016
Echinococcus multilocularis	g-protein coupled receptor	0.0027	0.002	0.0016
Echinococcus granulosus	neutral alpha glucosidase AB	0.0066	0.0091	0.0086
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.001	0.0006
Schistosoma mansoni	alpha-glucosidase	0.0267	0.0456	0.0452
Brugia malayi	hypothetical protein	0.0027	0.002	0.0016
Mycobacterium ulcerans	alpha-L-fucosidase	0.0423	0.0741	1
Brugia malayi	Abnormal catecholamine distribution protein 1	0.0576	0.1019	0.1014
Echinococcus granulosus	neuropeptide s receptor	0.0027	0.002	0.0016
Echinococcus granulosus	synaptic vesicular amine transporter	0.0576	0.1019	0.1014
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0066	0.0092	1
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0341	0.0591	0.4296
Echinococcus multilocularis	vesicular acetylcholine transporter	0.5517	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0027	0.002	0.0016
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0027	0.002	0.0016
Schistosoma mansoni	hypothetical protein	0.0033	0.0032	0.0028
Leishmania major	sterol C-24 reductase, putative	0.0047	0.0057	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0053	0.0048
Echinococcus granulosus	serotonin transporter	0.0388	0.0677	0.0673
Loa Loa (eye worm)	abnormal catecholamine distribution protein 1	0.0576	0.1019	0.1014
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0009	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0041	0.0036
Giardia lamblia	DINP protein human, muc B family	0.0021	0.001	0.0088
Echinococcus multilocularis	synaptic vesicular amine transporter	0.0576	0.1019	0.1014
Schistosoma mansoni	glycogen phosphorylase	0.0341	0.0591	0.0587
Leishmania major	alpha glucosidase II subunit, putative	0.0066	0.0091	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Echinococcus multilocularis	g protein coupled receptor	0.0027	0.002	0.0016
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0027	0.002	0.0016
Loa Loa (eye worm)	serotonin transporter b	0.0388	0.0677	0.0672
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0018	0.0005	0.0519
Brugia malayi	AKH receptor	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0223	0.0218
Echinococcus granulosus	biogenic amine 5HT receptor	0.0027	0.002	0.0016
Leishmania major	C-8 sterol isomerase-like protein	0.4639	0.8403	1
Entamoeba histolytica	glycogenphosphorylase, putative	0.0147	0.024	0.3962
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.002	0.0016
Trichomonas vaginalis	glucosylceramidase, putative	0.0505	0.0889	0.6479
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0009	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0027	0.002	0.0016
Brugia malayi	hypothetical protein	0.0027	0.002	0.0016
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0027	0.002	0.0016
Treponema pallidum	sodium- and chloride- dependent transporter	0.0388	0.0677	1
Loa Loa (eye worm)	TYRA-2 protein	0.0027	0.002	0.0015
Brugia malayi	sulfakinin receptor protein	0.0027	0.002	0.0016
Loa Loa (eye worm)	glycogen phosphorylase	0.0341	0.0591	0.0586
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0041	0.0266
Trypanosoma cruzi	sterol C-24 reductase, putative	0.0047	0.0057	0.0062
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0009	0.0946
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0009	0.0004
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0032	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.001	0.0006
Echinococcus granulosus	dna polymerase eta	0.0021	0.001	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Echinococcus granulosus	7TM GPCR rhodopsin	0.0027	0.002	0.0016
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0066	0.0091	0.0086
Schistosoma mansoni	histamine h1 receptor	0.0027	0.002	0.0016
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0032	0.0027
Loa Loa (eye worm)	neuropeptide F receptor	0.0027	0.002	0.0015
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0006
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0027	0.002	0.0016
Echinococcus multilocularis	neuropeptide Y receptor	0.0027	0.002	0.0016
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0032	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0257	0.0438	0.0433
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0066	0.0092	0.0087
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0032	0.0027
Leishmania major	C-14 sterol reductase, putative	0.009	0.0136	0.0156
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.001	0.007
Schistosoma mansoni	hypothetical protein	0.0052	0.0067	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0066	0.0091	0.1411
Loa Loa (eye worm)	hypothetical protein	0.0021	0.001	0.0004
Echinococcus multilocularis	dna polymerase eta	0.0021	0.001	0.0005
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0027	0.002	0.0016
Echinococcus multilocularis	lamin b receptor	0.009	0.0136	0.0131
Schistosoma mansoni	adenoreceptor	0.0027	0.002	0.0016
Trichomonas vaginalis	glucosylceramidase, putative	0.0769	0.137	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0027	0.002	0.0015
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0276	0.0474	0.0469
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0053	0.0048
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0006
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0009	0.0004
Trichomonas vaginalis	glucosylceramidase, putative	0.0532	0.0938	0.684
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0027	0.002	0.0015
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.001	0.0005
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.006	0.0056
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.006	0.0056
Schistosoma mansoni	neuropeptide receptor	0.0027	0.002	0.0016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0092	0.0086
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0119	0.0188	0.7812
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0053	0.0048
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0027	0.002	0.0016
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0112	0.0176	0.1253
Echinococcus multilocularis	somatostatin receptor	0.0027	0.002	0.0016
Brugia malayi	GnHR receptor homolog	0.0027	0.002	0.0016
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0066	0.0091	0.0633
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0006
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0066	0.0092	0.0087
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0041	0.0266
Schistosoma mansoni	growth hormone secretagogue receptor	0.0027	0.002	0.0016
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0032	0.0027
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.001	0.0004
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0018	0.0005	0.0484
Echinococcus granulosus	G protein coupled receptor 139	0.0027	0.002	0.0016
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0112	0.0176	0.1253
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0006
Brugia malayi	Melatonin receptor type 1A	0.0027	0.002	0.0016
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Schistosoma mansoni	amine GPCR	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0006
Brugia malayi	G protein-coupled receptor	0.0027	0.002	0.0016
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0066	0.0092	0.0087
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0027	0.002	0.0016
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0027	0.002	0.0016
Schistosoma mansoni	hypothetical protein	0.0027	0.002	0.0016
Entamoeba histolytica	glycogen phosphorylase, putative	0.0341	0.0591	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0038	0.0041	0.0266
Echinococcus granulosus	dro:myosuppressin receptor	0.0027	0.002	0.0016
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0041	0.0266
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.002	0.0016
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0066	0.0092	0.0087
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.002	0.0016
Brugia malayi	neuropeptide F receptor	0.0027	0.002	0.0016
Loa Loa (eye worm)	G-protein coupled receptor	0.0027	0.002	0.0015
Plasmodium vivax	thioredoxin reductase, putative	0.0052	0.0067	0.7272
Echinococcus multilocularis	serotonin transporter	0.0388	0.0677	0.0673
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0066	0.0092	0.0087
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0032	0.0027
Echinococcus multilocularis	serotonin receptor	0.0027	0.002	0.0016
Toxoplasma gondii	NADPH-glutathione reductase	0.0018	0.0005	0.0519
Brugia malayi	larval opioid receptor	0.0027	0.002	0.0016
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.002	0.0016
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0066	0.0092	0.0087
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0009	0.018
Trypanosoma brucei	glucosidase, putative	0.0066	0.0091	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0223	0.0218
Giardia lamblia	Glycogen phosphorylase	0.0341	0.0591	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0066	0.0092	0.0087
Schistosoma mansoni	hypothetical protein	0.0027	0.002	0.0016
Trichomonas vaginalis	glucosylceramidase, putative	0.0769	0.137	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0067	0.0062
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.002	0.0016
Echinococcus multilocularis	fmrfamide receptor	0.0027	0.002	0.0016
Brugia malayi	Bloom's syndrome protein homolog	0.0023	0.0014	0.0009
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.001	0.0005
Echinococcus multilocularis	beta galactosidase	0.0138	0.0223	0.0219
Echinococcus multilocularis	neuropeptide receptor	0.0027	0.002	0.0016
Trypanosoma cruzi	C-14 sterol reductase, putative	0.009	0.0136	0.0156
Trichomonas vaginalis	glucosylceramidase, putative	0.0769	0.137	1
Entamoeba histolytica	glycogen phosphorylase, putative	0.0147	0.024	0.3962
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0021	0.001	0.0038
Brugia malayi	follicle stimulating hormone receptor	0.0276	0.0474	0.0469
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0066	0.0091	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0009	0.0004
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0041	0.0266
Schistosoma mansoni	sodium/chloride dependent transporter	0.0388	0.0677	0.0673
Echinococcus granulosus	neuropeptide receptor	0.0027	0.002	0.0016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.002	0.0016
Brugia malayi	hypothetical protein	0.0257	0.0438	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Echinococcus granulosus	vesicular acetylcholine transporter	0.5517	1	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0027	0.002	0.0016
Trypanosoma cruzi	sterol C-24 reductase, putative	0.0047	0.0057	0.0062
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0006
Echinococcus granulosus	lamin b receptor	0.009	0.0136	0.0131
Toxoplasma gondii	exonuclease III APE	0.002	0.0009	0.0979
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0009	0.0005
Echinococcus granulosus	neuropeptide Y receptor	0.0027	0.002	0.0016
Brugia malayi	Dopamine receptor protein 2	0.0027	0.002	0.0016
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.001	0.0006
Echinococcus granulosus	fucosidase alpha L 1 tissue	0.0423	0.0741	0.0736
Brugia malayi	putative neuropeptide receptor	0.0027	0.002	0.0016
Echinococcus multilocularis	dro:myosuppressin receptor	0.0027	0.002	0.0016
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0769	0.137	0.1365
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0769	0.137	0.1366
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0066	0.0092	0.0087
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0027	0.002	0.0015
Loa Loa (eye worm)	alpha-L-fucosidase	0.0256	0.0437	0.0432
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0066	0.0092	0.0087
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0066	0.0092	0.1482
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0032	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0066	0.0091	0.1411
Echinococcus multilocularis	neuropeptides capa receptor	0.0027	0.002	0.0016
Echinococcus granulosus	dna polymerase kappa	0.0021	0.001	0.0005
Echinococcus multilocularis	orexin receptor type 2	0.0027	0.002	0.0016
Plasmodium vivax	hypothetical protein, conserved	0.0066	0.0092	1
Echinococcus multilocularis	glycogen phosphorylase	0.0341	0.0591	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0027	0.002	0.0016
Brugia malayi	carbohydrate phosphorylase	0.0341	0.0591	0.0587
Brugia malayi	hypothetical protein	0.0066	0.0092	0.0087
Onchocerca volvulus		0.0261	0.0447	0.0428
Schistosoma mansoni	hypothetical protein	0.0027	0.002	0.0016
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0027	0.002	0.0016
Loa Loa (eye worm)	norepinephrine transporter	0.0388	0.0677	0.0672
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0147	0.024	0.3192
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Brugia malayi	Serotonin receptor	0.0027	0.002	0.0016
Trypanosoma brucei	unspecified product	0.0021	0.001	0.0006
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0027	0.002	0.0016
Loa Loa (eye worm)	RecQ helicase	0.0023	0.0014	0.0009
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Trichomonas vaginalis	alpha-glucosidase, putative	0.0066	0.0091	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0388	0.0677	0.0672
Plasmodium falciparum	transporter, putative	0.0066	0.0092	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0532	0.0938	0.684
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0027	0.002	0.0016
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0009	0.0005
Schistosoma mansoni	hypothetical protein	0.0536	0.0947	0.0943
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0006
Onchocerca volvulus		0.0033	0.0032	0.0011
Onchocerca volvulus		0.0066	0.0092	0.0071
Schistosoma mansoni	neuropeptide receptor	0.0027	0.002	0.0016
Echinococcus granulosus	tm gpcr rhodopsin	0.1647	0.2967	0.2963
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0027	0.002	0.0016
Trichomonas vaginalis	glucosylceramidase, putative	0.0505	0.0889	0.6479
Onchocerca volvulus		0.0066	0.0092	0.0071
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0027	0.002	0.0016
Schistosoma mansoni	amine GPCR	0.0027	0.002	0.0016
Echinococcus multilocularis	survival motor neuron protein 1	0.0257	0.0438	0.0434
Brugia malayi	glutathione reductase	0.0052	0.0067	0.0062
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0066	0.0091	0.9941
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.001	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0294	0.0506	0.0502
Echinococcus granulosus	neuropeptide receptor	0.0027	0.002	0.0016
Trypanosoma brucei	trypanothione reductase	0.0052	0.0067	0.0074
Brugia malayi	hypothetical protein	0.0027	0.002	0.0016
Trypanosoma cruzi	C-14 sterol reductase, putative	0.009	0.0136	0.0156
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0066	0.0092	0.0087
Brugia malayi	Alpha-L-fucosidase family protein	0.0256	0.0437	0.0432
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0119	0.0188	0.7812
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0032	0.0027
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.002	0.0016
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0341	0.0591	0.0572
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0038	0.0041	0.0043
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0027	0.002	0.0016
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0009	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.001	0.0005
Schistosoma mansoni	glycogen phosphorylase	0.0341	0.0591	0.0587
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.001	0.0221
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.001	0.0006
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0027	0.002	0.0016
Brugia malayi	ORL1-like opioid receptor	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0049	0.006	0.0055
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0027	0.002	0.0016
Plasmodium falciparum	amino acid transporter, putative	0.0066	0.0092	1
Echinococcus granulosus	glycogen phosphorylase	0.0341	0.0591	0.0587
Mycobacterium tuberculosis	Probable dehydrogenase	0.0119	0.0188	0.7812
Plasmodium vivax	amine transporter, putative	0.0066	0.0092	1
Schistosoma mansoni	beta-galactosidase	0.0138	0.0223	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0388	0.0677	0.0673
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0119	0.0188	0.7812
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0032	0.0026
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0027	0.002	0.0016
Schistosoma mansoni	alpha-glucosidase	0.0267	0.0456	0.0452
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0132	0.0212	0.884
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Schistosoma mansoni	hypothetical protein	0.0536	0.0947	0.0943
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.023	0.0389	0.0384
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0027	0.002	0.0016
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0066	0.0092	0.0087
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0027	0.002	0.0016
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0341	0.0591	0.0587
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0041	0.0266
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0041	0.0266
Echinococcus granulosus	tm gpcr rhodopsin	0.0027	0.002	0.0016
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.5517	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0027	0.002	0.0016
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0092	0.0086
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.002	0.0016
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0027	0.002	0.0016
Echinococcus multilocularis	serotonin receptor	0.0027	0.002	0.0016
Schistosoma mansoni	Lamin B receptor (ERG24)	0.009	0.0136	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0057	0.0052
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.002	0.0016
Brugia malayi	G-protein coupled receptor	0.0027	0.002	0.0016
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.001	0.007
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0066	0.0092	0.0087
Echinococcus multilocularis	neuropeptide receptor	0.0027	0.002	0.0016
Leishmania major	glycosyl hydrolase-like protein	0.0038	0.0041	0.0043
Brugia malayi	Pre-SET motif family protein	0.023	0.0389	0.0385
Loa Loa (eye worm)	neuropeptide F receptor	0.0027	0.002	0.0015
Schistosoma mansoni	ap endonuclease	0.002	0.0009	0.0004
Echinococcus granulosus	glycogen phosphorylase	0.0341	0.0591	0.0587
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.001	0.0006
Schistosoma mansoni	neuropeptide f receptor 76f	0.0027	0.002	0.0016
Schistosoma mansoni	hypothetical protein	0.0027	0.002	0.0016
Echinococcus granulosus	neuropeptides capa receptor	0.0027	0.002	0.0016
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0009	1
Schistosoma mansoni	opsin-like receptor	0.0027	0.002	0.0016
Mycobacterium tuberculosis	Probable oxidoreductase	0.0132	0.0212	0.884
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.002	0.0016
Schistosoma mansoni	amine GPCR	0.0027	0.002	0.0016
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0027	0.002	0.0015
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0066	0.0092	0.0087
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0053	0.0048
Trichomonas vaginalis	alpha-glucosidase, putative	0.0066	0.0091	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0092	0.0086
Schistosoma mansoni	glycogen phosphorylase	0.0147	0.024	0.0235
Echinococcus granulosus	orexin receptor type 2	0.0027	0.002	0.0016
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0041	0.0266
Trichomonas vaginalis	glucosylceramidase, putative	0.0769	0.137	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Schistosoma mansoni	neuropeptide F-like receptor	0.0027	0.002	0.0016
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.002	0.0016
Trichomonas vaginalis	alpha-glucosidase, putative	0.0066	0.0091	0.0633
Trypanosoma cruzi	DNA polymerase eta, putative	0.0021	0.001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0027	0.002	0.0016
Echinococcus granulosus	neuropeptide receptor A26	0.0027	0.002	0.0016
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0009	0.0005
Trichomonas vaginalis	glucosylceramidase, putative	0.0505	0.0889	0.6479
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0027	0.002	0.0016
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0388	0.0677	0.0673
Loa Loa (eye worm)	hypothetical protein	0.2371	0.4281	0.4278
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0027	0.002	0.0016
Echinococcus granulosus	bloom syndrome protein	0.0023	0.0014	0.0009
Loa Loa (eye worm)	glutathione reductase	0.0052	0.0067	0.0061
Echinococcus multilocularis	sex peptide receptor	0.0027	0.002	0.0016
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.001	0.0221
Loa Loa (eye worm)	hypothetical protein	0.4639	0.8403	0.8402
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0021	0.001	0.0017
Brugia malayi	Dopamine receptor	0.0027	0.002	0.0016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.002	0.0016
Echinococcus granulosus	geminin	0.0536	0.0947	0.0943
Echinococcus multilocularis	g protein coupled receptor	0.0027	0.002	0.0016
Brugia malayi	Pre-SET motif family protein	0.0033	0.0032	0.0027
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.002	0.0016
Echinococcus granulosus	hypothetical protein	0.0027	0.002	0.0016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.002	0.0016
Plasmodium falciparum	thioredoxin reductase	0.0052	0.0067	0.7133
Trypanosoma brucei	C-8 sterol isomerase, putative	0.4639	0.8403	1
Brugia malayi	hypothetical protein	0.0027	0.002	0.0016
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.003	0.0025
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.001	0.0005
Brugia malayi	neuropeptide F receptor	0.0027	0.002	0.0016
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.006	0.0055
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0066	0.0092	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0053	0.0048
Trichomonas vaginalis	alpha-glucosidase, putative	0.0066	0.0091	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.002	0.0016
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.002	0.0016
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.001	0.0005
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0027	0.002	0.0016
Echinococcus granulosus	fmrfamide receptor	0.0027	0.002	0.0016
Plasmodium vivax	SET domain protein, putative	0.0033	0.0032	0.3442
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0038	0.0041	0.0036
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.5517	1	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0021	0.001	0.0006
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0294	0.0506	0.0501
Echinococcus granulosus	sodium and chloride dependent glycine	0.0066	0.0092	0.0087
Toxoplasma gondii	hypothetical protein	0.0066	0.0092	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0032	0.0027
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0009	0.0485
Trypanosoma cruzi	hypothetical protein, conserved	0.0066	0.0091	0.0103
Echinococcus granulosus	thioredoxin glutathione reductase	0.0052	0.0067	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0092	0.0086
Echinococcus granulosus	lysosomal alpha glucosidase	0.0294	0.0506	0.0502
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.001	0.0006
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0027	0.002	0.0016
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0027	0.002	0.0015
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0027	0.002	0.0016
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0038	0.0041	0.0043
Echinococcus granulosus	g protein coupled receptor	0.0027	0.002	0.0016
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0052	0.0067	0.0062
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0066	0.0092	0.0087
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0066	0.0091	0.0086
Echinococcus granulosus	rhodopsin orphan GPCR	0.0027	0.002	0.0016
Echinococcus granulosus	g protein coupled receptor	0.0027	0.002	0.0016
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0147	0.024	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0027	0.002	0.0016
Loa Loa (eye worm)	G-protein coupled receptor	0.0027	0.002	0.0015
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0132	0.0212	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.001	0.0005
Brugia malayi	Dopamine receptor protein 1	0.0027	0.002	0.0016
Brugia malayi	hypothetical protein	0.0027	0.002	0.0016
Brugia malayi	G protein-coupled receptor F59B2.13	0.0027	0.002	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.0015
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0066	0.0092	0.0087
Echinococcus granulosus	serotonin receptor	0.0027	0.002	0.0016
Schistosoma mansoni	alpha-l-fucosidase	0.0256	0.0437	0.0432
Schistosoma mansoni	amine GPCR	0.0027	0.002	0.0016
Echinococcus granulosus	allatostatin A receptor	0.0027	0.002	0.0016
Schistosoma mansoni	myosin xvIII	0.0027	0.002	0.0016
Trichomonas vaginalis	glucosylceramidase, putative	0.0505	0.0889	0.6479
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0027	0.002	0.0016
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0009	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.002	0.0016
Trichomonas vaginalis	set domain proteins, putative	0.0261	0.0447	0.324
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0018	0.0005	0.0484
Echinococcus multilocularis	geminin	0.0536	0.0947	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0388	0.0677	0.0672
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0027	0.002	0.0016
Trichomonas vaginalis	DNA helicase recq, putative	0.0023	0.0014	0.0067
Echinococcus granulosus	tm gpcr rhodopsin	0.0027	0.002	0.0016
Plasmodium vivax	glutathione reductase, putative	0.0052	0.0067	0.7272
Brugia malayi	hypothetical protein	0.0027	0.002	0.0016
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0009	0.0472
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.4639	0.8403	1
Trypanosoma brucei	C-14 sterol reductase, putative	0.009	0.0136	0.0156
Leishmania major	DNA polymerase kappa, putative	0.0021	0.001	0.0006
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0027	0.002	0.0016
Trypanosoma cruzi	trypanothione reductase, putative	0.0052	0.0067	0.0074
Schistosoma mansoni	sodium/chloride dependent transporter	0.0066	0.0092	0.0087
Brugia malayi	hypothetical protein	0.0027	0.002	0.0016
Chlamydia trachomatis	glycogen phosphorylase	0.0341	0.0591	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0053	0.0048
Plasmodium falciparum	glutathione reductase	0.0052	0.0067	0.7133
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0066	0.0091	0.0633
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.4639	0.8403	0.8403
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0038	0.0041	0.0043
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0032	0.3466
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0027	0.002	0.0016
Schistosoma mansoni	sodium/chloride dependent transporter	0.0066	0.0092	0.0087
Trichomonas vaginalis	glucosylceramidase, putative	0.0505	0.0889	0.6479
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0053	0.0048
Leishmania major	DNA polymerase eta, putative	0.0021	0.001	0.0006
Trypanosoma cruzi	hypothetical protein, conserved	0.0066	0.0091	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0388	0.0677	0.0672
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0066	0.0092	1
Echinococcus multilocularis	fmrfamide receptor	0.0027	0.002	0.0016
Trichomonas vaginalis	glucosylceramidase, putative	0.0505	0.0889	0.6479
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0066	0.0092	0.0086
Entamoeba histolytica	glycogen phosphorylase, putative	0.0341	0.0591	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0027	0.002	0.0016
Echinococcus granulosus	7tm_1 domain containing protein	0.0027	0.002	0.0016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0006
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0027	0.002	0.0016
Toxoplasma gondii	thioredoxin reductase	0.0052	0.0067	0.7282
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1647	0.2967	0.2963
Schistosoma mansoni	neuropeptide receptor	0.0027	0.002	0.0016
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0132	0.0212	0.884

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1189215

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1144702